MOCS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.27116595
2DNA deamination (GO:0045006)5.09218964
3response to pheromone (GO:0019236)4.30638045
4RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.23127740
5tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.23127740
6protein complex biogenesis (GO:0070271)4.02128122
7proline biosynthetic process (GO:0006561)4.01847397
8folic acid-containing compound biosynthetic process (GO:0009396)3.95581831
9mitochondrial respiratory chain complex assembly (GO:0033108)3.92408431
10formation of translation preinitiation complex (GO:0001731)3.88526050
11viral transcription (GO:0019083)3.84293246
12translational termination (GO:0006415)3.79997254
13ribosome biogenesis (GO:0042254)3.76915724
14maturation of 5.8S rRNA (GO:0000460)3.74881125
15protein-cofactor linkage (GO:0018065)3.70244651
16cellular ketone body metabolic process (GO:0046950)3.66548856
17water-soluble vitamin biosynthetic process (GO:0042364)3.66365360
18mannosylation (GO:0097502)3.63973365
19rRNA modification (GO:0000154)3.63833408
20keratinocyte development (GO:0003334)3.62182344
21cytochrome complex assembly (GO:0017004)3.59317831
22folic acid metabolic process (GO:0046655)3.58832984
23respiratory chain complex IV assembly (GO:0008535)3.57961001
24translational elongation (GO:0006414)3.56730936
25platelet dense granule organization (GO:0060155)3.53229410
26translational initiation (GO:0006413)3.52329820
27glycine metabolic process (GO:0006544)3.50087560
28ribosomal small subunit assembly (GO:0000028)3.49106732
29preassembly of GPI anchor in ER membrane (GO:0016254)3.47711985
30ribonucleoprotein complex biogenesis (GO:0022613)3.46092620
31rRNA methylation (GO:0031167)3.43275823
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.42091951
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40061523
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.40061523
35NADH dehydrogenase complex assembly (GO:0010257)3.40061523
36ribosomal small subunit biogenesis (GO:0042274)3.33308926
37L-fucose metabolic process (GO:0042354)3.32210466
38L-fucose catabolic process (GO:0042355)3.32210466
39fucose catabolic process (GO:0019317)3.32210466
40regulation of translational termination (GO:0006449)3.32090856
41antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.30802941
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.30802941
43detection of light stimulus involved in sensory perception (GO:0050962)3.29127935
44detection of light stimulus involved in visual perception (GO:0050908)3.29127935
45nucleobase biosynthetic process (GO:0046112)3.29105879
46CTP metabolic process (GO:0046036)3.27764963
47CTP biosynthetic process (GO:0006241)3.27764963
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.27448724
49ketone body metabolic process (GO:1902224)3.27293545
50negative regulation of telomere maintenance (GO:0032205)3.24600687
51ribosomal large subunit biogenesis (GO:0042273)3.23044029
52protein polyglutamylation (GO:0018095)3.23027361
53piRNA metabolic process (GO:0034587)3.20846836
54pseudouridine synthesis (GO:0001522)3.20265178
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19931771
56maturation of SSU-rRNA (GO:0030490)3.19034135
57gamma-aminobutyric acid transport (GO:0015812)3.17720646
58maternal placenta development (GO:0001893)3.16894924
59DNA strand elongation involved in DNA replication (GO:0006271)3.16809152
60mitotic G1 DNA damage checkpoint (GO:0031571)3.16487551
61L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15973921
62* tRNA processing (GO:0008033)3.14359780
63transcription from mitochondrial promoter (GO:0006390)3.12917520
64indolalkylamine metabolic process (GO:0006586)3.12246994
65protein targeting to ER (GO:0045047)3.12140834
66embryonic process involved in female pregnancy (GO:0060136)3.09387327
67peptidyl-arginine omega-N-methylation (GO:0035247)3.09180494
68mitotic nuclear envelope disassembly (GO:0007077)3.09014825
69cotranslational protein targeting to membrane (GO:0006613)3.06008619
70heterochromatin organization (GO:0070828)3.05950321
71fusion of sperm to egg plasma membrane (GO:0007342)3.05466598
72regulation of RNA export from nucleus (GO:0046831)3.05451125
73indole-containing compound catabolic process (GO:0042436)3.05197729
74indolalkylamine catabolic process (GO:0046218)3.05197729
75tryptophan catabolic process (GO:0006569)3.05197729
76ubiquinone biosynthetic process (GO:0006744)3.04404412
77epithelial cilium movement (GO:0003351)3.03595675
78pteridine-containing compound biosynthetic process (GO:0042559)3.03445679
79DNA replication-dependent nucleosome organization (GO:0034723)3.03344086
80DNA replication-dependent nucleosome assembly (GO:0006335)3.03344086
81DNA replication checkpoint (GO:0000076)3.03341133
82* tRNA modification (GO:0006400)3.01418173
83purine nucleobase biosynthetic process (GO:0009113)2.99911598
84multicellular organism reproduction (GO:0032504)2.99456805
85protein localization to chromosome, centromeric region (GO:0071459)2.97515839
86rRNA processing (GO:0006364)2.97326545
87DNA strand elongation (GO:0022616)2.96131659
88protein localization to endoplasmic reticulum (GO:0070972)2.95650034
89establishment of protein localization to endoplasmic reticulum (GO:0072599)2.94543471
90DNA replication initiation (GO:0006270)2.93609668
91telomere maintenance via semi-conservative replication (GO:0032201)2.93484340
92rRNA metabolic process (GO:0016072)2.91212803
93kynurenine metabolic process (GO:0070189)2.90857601
94nuclear envelope disassembly (GO:0051081)2.90550098
95membrane disassembly (GO:0030397)2.90550098
96regulation of cilium movement (GO:0003352)2.89523665
97cellular protein complex disassembly (GO:0043624)2.88886147
98mitochondrial DNA metabolic process (GO:0032042)2.87733610
99pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.87657812
100regulation of mitochondrial translation (GO:0070129)2.87479161
101cell wall macromolecule catabolic process (GO:0016998)2.87406717
102cell wall macromolecule metabolic process (GO:0044036)2.87406717
103epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.87381859
104cornea development in camera-type eye (GO:0061303)2.86453931
105nonmotile primary cilium assembly (GO:0035058)2.85947837
106ribosome assembly (GO:0042255)2.84935083
107viral life cycle (GO:0019058)2.84645288
108sperm-egg recognition (GO:0035036)2.84611430
109organic cation transport (GO:0015695)2.82838984
110DNA double-strand break processing (GO:0000729)2.82454103
111protein localization to kinetochore (GO:0034501)2.81474534
112nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81106737
113binding of sperm to zona pellucida (GO:0007339)2.81027145
114regulation of translational fidelity (GO:0006450)2.81020046
115dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.80943751
116ubiquinone metabolic process (GO:0006743)2.80227314
117pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.78855856
118detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.77598814
119protein complex localization (GO:0031503)2.76532435
120mitotic G1/S transition checkpoint (GO:0044819)2.76504387
121sperm motility (GO:0030317)2.76212318
122spliceosomal snRNP assembly (GO:0000387)2.75989631
123ncRNA 3-end processing (GO:0043628)2.74127590
124synaptonemal complex assembly (GO:0007130)2.74026329
125regulation of nuclear cell cycle DNA replication (GO:0033262)2.73489512
126regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.73442636
127antigen processing and presentation of endogenous antigen (GO:0019883)2.72740685
128interferon-gamma secretion (GO:0072643)2.72299982
129proline metabolic process (GO:0006560)2.71539812
130positive regulation of prostaglandin secretion (GO:0032308)2.71503136
131negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.71445179
132protein complex disassembly (GO:0043241)2.70774335
133sulfation (GO:0051923)2.70511892
134L-serine metabolic process (GO:0006563)2.70156158
135regulation of gene silencing by RNA (GO:0060966)2.70149352
136regulation of posttranscriptional gene silencing (GO:0060147)2.70149352
137regulation of gene silencing by miRNA (GO:0060964)2.70149352
138regulation of chromatin binding (GO:0035561)2.69891810
139serine family amino acid biosynthetic process (GO:0009070)2.69439930
140mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.67751055
141pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.65459005
142histone arginine methylation (GO:0034969)2.65278559
143exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.64933299
144peptidyl-arginine methylation (GO:0018216)2.64417650
145peptidyl-arginine N-methylation (GO:0035246)2.64417650
146GTP biosynthetic process (GO:0006183)2.63762645
147nucleoside salvage (GO:0043174)2.63362909
148GPI anchor metabolic process (GO:0006505)2.62943591
149regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.62143317
150regulation of mitotic spindle checkpoint (GO:1903504)2.62143317
151synaptonemal complex organization (GO:0070193)2.62031903
152tryptophan metabolic process (GO:0006568)2.61770187
153pentose-phosphate shunt (GO:0006098)2.61137366
154serine family amino acid metabolic process (GO:0009069)2.61082747
155ATP synthesis coupled proton transport (GO:0015986)2.60829777
156energy coupled proton transport, down electrochemical gradient (GO:0015985)2.60829777
157L-methionine salvage (GO:0071267)2.60621276
158L-methionine biosynthetic process (GO:0071265)2.60621276
159amino acid salvage (GO:0043102)2.60621276
160mitochondrial RNA metabolic process (GO:0000959)2.60187524
161glycerol ether metabolic process (GO:0006662)2.59803297
162nuclear envelope organization (GO:0006998)2.59690999
163acrosome assembly (GO:0001675)2.58734584
164maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.58612427
165RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.57933753
166somatic diversification of immune receptors via somatic mutation (GO:0002566)2.55692378
167somatic hypermutation of immunoglobulin genes (GO:0016446)2.55692378
168DNA methylation involved in gamete generation (GO:0043046)2.55376612
169G1 DNA damage checkpoint (GO:0044783)2.55369212
170positive regulation of mitochondrial fission (GO:0090141)2.55290044
171recombinational repair (GO:0000725)2.54883128
172cell-cell recognition (GO:0009988)2.53851832
173tetrahydrofolate metabolic process (GO:0046653)2.53556559
174spermatid development (GO:0007286)2.53297096
175mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.53281951
176macromolecular complex disassembly (GO:0032984)2.52845645
177regulation of translation in response to stress (GO:0043555)2.52610726
178translesion synthesis (GO:0019985)2.52462837
179nuclear pore complex assembly (GO:0051292)2.52379016
180nuclear pore organization (GO:0006999)2.52074598
181double-strand break repair via homologous recombination (GO:0000724)2.51896908
182pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.51848974
183IMP biosynthetic process (GO:0006188)2.51747993
184base-excision repair, AP site formation (GO:0006285)2.51718919
185folic acid-containing compound metabolic process (GO:0006760)2.51133702
186S-adenosylmethionine metabolic process (GO:0046500)2.49383356
187primary amino compound metabolic process (GO:1901160)2.48795919
188chaperone-mediated protein complex assembly (GO:0051131)2.48579484
189mitotic metaphase plate congression (GO:0007080)2.48446384
190replication fork processing (GO:0031297)2.48033898
191serine family amino acid catabolic process (GO:0009071)2.47219787
192* RNA modification (GO:0009451)2.46187227
193nucleotide salvage (GO:0043173)2.46018487
194* tRNA metabolic process (GO:0006399)2.45921931
195anterograde synaptic vesicle transport (GO:0048490)2.43611270
196indole-containing compound metabolic process (GO:0042430)2.42776067
197transcription elongation from RNA polymerase III promoter (GO:0006385)2.42220136

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.84640121
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.74943624
3ZNF274_21170338_ChIP-Seq_K562_Hela3.99796351
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.50635725
5VDR_22108803_ChIP-Seq_LS180_Human3.42047317
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.31948375
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.13298271
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.83118252
9MYC_22102868_ChIP-Seq_BL_Human2.78604307
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.50434943
11IGF1R_20145208_ChIP-Seq_DFB_Human2.48617962
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.45167583
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45060955
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31076976
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12661626
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08706304
17GBX2_23144817_ChIP-Seq_PC3_Human2.07737557
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.06599167
19VDR_21846776_ChIP-Seq_THP-1_Human2.03685045
20EWS_26573619_Chip-Seq_HEK293_Human2.00750735
21MYC_18940864_ChIP-ChIP_HL60_Human1.94361468
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.92366017
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90759120
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88397382
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87526509
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.87312991
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84116581
28TAF15_26573619_Chip-Seq_HEK293_Human1.83124454
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82605579
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82513189
31IRF1_19129219_ChIP-ChIP_H3396_Human1.82007263
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.81536247
33* ELK1_19687146_ChIP-ChIP_HELA_Human1.81465357
34XRN2_22483619_ChIP-Seq_HELA_Human1.81263088
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81241628
36ER_23166858_ChIP-Seq_MCF-7_Human1.77905805
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76159682
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75233791
39FUS_26573619_Chip-Seq_HEK293_Human1.74225515
40TP53_22573176_ChIP-Seq_HFKS_Human1.70928558
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69632500
42P300_19829295_ChIP-Seq_ESCs_Human1.68708265
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.66834342
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63448576
45* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62994978
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62437367
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.59824151
48* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55426033
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53753512
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53467092
51VDR_23849224_ChIP-Seq_CD4+_Human1.52716324
52ZNF263_19887448_ChIP-Seq_K562_Human1.52089640
53GABP_19822575_ChIP-Seq_HepG2_Human1.49795634
54* GABP_17652178_ChIP-ChIP_JURKAT_Human1.47226705
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46685601
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46275802
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45759858
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.44326451
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44023045
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43887976
61* TCF7_22412390_ChIP-Seq_EML_Mouse1.43605781
62KDM5A_27292631_Chip-Seq_BREAST_Human1.42483005
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40809454
64CBP_20019798_ChIP-Seq_JUKART_Human1.40809454
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39852554
66DCP1A_22483619_ChIP-Seq_HELA_Human1.39700689
67MAF_26560356_Chip-Seq_TH1_Human1.38900038
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38387150
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36564035
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35731952
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33237596
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32949974
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32885197
74UTX_26944678_Chip-Seq_JUKART_Human1.30961739
75PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30326331
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29960930
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28937567
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28312521
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27522724
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27325887
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27128941
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26080035
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26052176
84ERA_21632823_ChIP-Seq_H3396_Human1.25812159
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25552644
86FOXP3_21729870_ChIP-Seq_TREG_Human1.25439720
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24865518
88RNF2_27304074_Chip-Seq_NSC_Mouse1.24863644
89HOXB7_26014856_ChIP-Seq_BT474_Human1.24350108
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.24131210
91ELK3_25401928_ChIP-Seq_HUVEC_Human1.23968688
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23556840
93NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23267866
94* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23223028
95MAF_26560356_Chip-Seq_TH2_Human1.22270072
96NCOR_22424771_ChIP-Seq_293T_Human1.21997694
97KDM2B_26808549_Chip-Seq_DND41_Human1.21993513
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21119863
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.19557400
100TFEB_21752829_ChIP-Seq_HELA_Human1.19312680
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.18842095
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18391732
103SALL1_21062744_ChIP-ChIP_HESCs_Human1.18037230
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17405959
105* TTF2_22483619_ChIP-Seq_HELA_Human1.17381603
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17287171
107* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17251930
108* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16323687
109* FOXA1_25329375_ChIP-Seq_VCAP_Human1.16323687
110NANOG_19829295_ChIP-Seq_ESCs_Human1.14632414
111SOX2_19829295_ChIP-Seq_ESCs_Human1.14632414
112MYB_26560356_Chip-Seq_TH1_Human1.14424947
113GATA3_21878914_ChIP-Seq_MCF-7_Human1.14317624
114E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14181337
115* AR_20517297_ChIP-Seq_VCAP_Human1.14153612
116TP63_19390658_ChIP-ChIP_HaCaT_Human1.13934914
117AR_21909140_ChIP-Seq_LNCAP_Human1.13831261
118LXR_22292898_ChIP-Seq_THP-1_Human1.13626938
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13514417
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12516436
121PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12509227
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12502251
123VDR_24763502_ChIP-Seq_THP-1_Human1.12031032
124GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11739938
125ATF3_27146783_Chip-Seq_COLON_Human1.11572295
126RXR_22158963_ChIP-Seq_LIVER_Mouse1.10040869
127IRF8_22096565_ChIP-ChIP_GC-B_Human1.09446472
128NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08850403
129E2F1_21310950_ChIP-Seq_MCF-7_Human1.08563716
130POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08324066
131NANOG_20526341_ChIP-Seq_ESCs_Human1.08075164
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07461135
133TET1_21451524_ChIP-Seq_MESCs_Mouse1.07398096
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06212835
135* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06206550
136EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05854986
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05460523
138ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05453933
139BCAT_22108803_ChIP-Seq_LS180_Human1.04993649
140PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04906953
141E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04895363
142SPI1_23547873_ChIP-Seq_NB4_Human1.04437518
143ELF1_20517297_ChIP-Seq_JURKAT_Human1.04335552
144ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04291352
145BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04136494
146KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03704203
147* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02705034
148CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02118037
149ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01894641
150ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01696377
151BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00965734
152EZH2_22144423_ChIP-Seq_EOC_Human1.00310679
153STAT3_23295773_ChIP-Seq_U87_Human1.00202175
154CTCF_21964334_Chip-Seq_Bcells_Human0.99119747
155* RUNX2_22187159_ChIP-Seq_PCA_Human0.98408290
156PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98059429
157AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97682219
158PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97649834
159FOXP1_21924763_ChIP-Seq_HESCs_Human0.97383364
160THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97159874
161MYB_26560356_Chip-Seq_TH2_Human0.96997142
162CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96305953
163RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95604398
164GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95590366
165SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95545468
166MYC_19829295_ChIP-Seq_ESCs_Human0.95361595
167NCOR1_26117541_ChIP-Seq_K562_Human0.95349010
168MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94573899
169FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94465979
170KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94126310
171CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93663660
172TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93171479
173REST_21632747_ChIP-Seq_MESCs_Mouse0.92834420
174AR_25329375_ChIP-Seq_VCAP_Human0.92521245
175FOXH1_21741376_ChIP-Seq_EPCs_Human0.91032744
176TCF4_23295773_ChIP-Seq_U87_Human0.90886269
177TCF4_22108803_ChIP-Seq_LS180_Human0.88654516
178NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88581388
179EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88222440
180TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87402237
181POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87402237
182OCT4_20526341_ChIP-Seq_ESCs_Human0.86443253
183TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86391294
184NFE2_27457419_Chip-Seq_LIVER_Mouse0.84650418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.49530424
2MP0003693_abnormal_embryo_hatching3.36398587
3MP0004957_abnormal_blastocyst_morpholog2.88306589
4MP0008877_abnormal_DNA_methylation2.70227968
5MP0008875_abnormal_xenobiotic_pharmacok2.61800784
6MP0005410_abnormal_fertilization2.59573766
7MP0006292_abnormal_olfactory_placode2.57994919
8MP0002102_abnormal_ear_morphology2.56315780
9MP0003111_abnormal_nucleus_morphology2.52295097
10MP0005645_abnormal_hypothalamus_physiol2.51106772
11MP0009278_abnormal_bone_marrow2.50002796
12MP0010352_gastrointestinal_tract_polyps2.42483536
13MP0003646_muscle_fatigue2.41729567
14MP0008057_abnormal_DNA_replication2.30072289
15MP0001545_abnormal_hematopoietic_system2.26053835
16MP0005397_hematopoietic_system_phenotyp2.26053835
17MP0010094_abnormal_chromosome_stability2.22903984
18MP0005551_abnormal_eye_electrophysiolog2.19695804
19MP0003195_calcinosis2.17953622
20MP0010307_abnormal_tumor_latency2.11843216
21MP0002837_dystrophic_cardiac_calcinosis2.06420992
22MP0003077_abnormal_cell_cycle2.04863080
23MP0006072_abnormal_retinal_apoptosis1.99922754
24MP0009840_abnormal_foam_cell1.99542689
25MP0002160_abnormal_reproductive_system1.96230760
26MP0002163_abnormal_gland_morphology1.95023485
27MP0004133_heterotaxia1.94993635
28MP0008872_abnormal_physiological_respon1.93328523
29MP0003718_maternal_effect1.91004348
30MP0002938_white_spotting1.89358488
31MP0009333_abnormal_splenocyte_physiolog1.88361294
32MP0000372_irregular_coat_pigmentation1.84627913
33MP0001968_abnormal_touch/_nociception1.84081532
34MP0001529_abnormal_vocalization1.83708263
35MP0005076_abnormal_cell_differentiation1.82916406
36MP0000490_abnormal_crypts_of1.74931456
37MP0004142_abnormal_muscle_tone1.73479772
38MP0003806_abnormal_nucleotide_metabolis1.72301114
39MP0002876_abnormal_thyroid_physiology1.71826908
40MP0003436_decreased_susceptibility_to1.69597698
41MP0004808_abnormal_hematopoietic_stem1.68845416
42MP0003705_abnormal_hypodermis_morpholog1.68383821
43MP0000427_abnormal_hair_cycle1.67807500
44MP0009046_muscle_twitch1.65916498
45MP0005389_reproductive_system_phenotype1.65618418
46MP0002877_abnormal_melanocyte_morpholog1.62901704
47MP0005084_abnormal_gallbladder_morpholo1.61659681
48MP0005379_endocrine/exocrine_gland_phen1.61429176
49MP0002139_abnormal_hepatobiliary_system1.61290638
50MP0001730_embryonic_growth_arrest1.59251168
51MP0008789_abnormal_olfactory_epithelium1.58969689
52MP0000685_abnormal_immune_system1.57952442
53MP0002736_abnormal_nociception_after1.53898098
54MP0002396_abnormal_hematopoietic_system1.53103382
55MP0003787_abnormal_imprinting1.52372781
56MP0005646_abnormal_pituitary_gland1.51726106
57MP0005360_urolithiasis1.51507048
58MP0000538_abnormal_urinary_bladder1.51040445
59MP0000350_abnormal_cell_proliferation1.50995409
60MP0000689_abnormal_spleen_morphology1.49692835
61MP0002398_abnormal_bone_marrow1.49471147
62MP0002405_respiratory_system_inflammati1.49264391
63MP0003763_abnormal_thymus_physiology1.47973018
64MP0006276_abnormal_autonomic_nervous1.47916228
65MP0001929_abnormal_gametogenesis1.45933762
66MP0005253_abnormal_eye_physiology1.45505273
67MP0005365_abnormal_bile_salt1.44665232
68MP0001800_abnormal_humoral_immune1.42390388
69MP0003136_yellow_coat_color1.39516835
70MP0001984_abnormal_olfaction1.39416026
71MP0008058_abnormal_DNA_repair1.38839048
72MP0002019_abnormal_tumor_incidence1.38117889
73MP0002722_abnormal_immune_system1.36656476
74MP0009745_abnormal_behavioral_response1.34315612
75MP0000631_abnormal_neuroendocrine_gland1.33680700
76MP0003300_gastrointestinal_ulcer1.33057545
77MP0005085_abnormal_gallbladder_physiolo1.30173965
78MP0010386_abnormal_urinary_bladder1.30157620
79MP0000703_abnormal_thymus_morphology1.28746085
80MP0001919_abnormal_reproductive_system1.26610585
81MP0001905_abnormal_dopamine_level1.25988822
82MP0002080_prenatal_lethality1.23626603
83MP0002234_abnormal_pharynx_morphology1.22961253
84MP0004742_abnormal_vestibular_system1.22433224
85MP0001697_abnormal_embryo_size1.22203851
86MP0001672_abnormal_embryogenesis/_devel1.21841738
87MP0005380_embryogenesis_phenotype1.21841738
88MP0001873_stomach_inflammation1.20946490
89MP0000609_abnormal_liver_physiology1.20898299
90MP0000858_altered_metastatic_potential1.20241641
91MP0008995_early_reproductive_senescence1.19897719
92MP0002086_abnormal_extraembryonic_tissu1.19639524
93MP0000313_abnormal_cell_death1.19395255
94MP0006035_abnormal_mitochondrial_morpho1.16647115
95MP0002272_abnormal_nervous_system1.16544048
96MP0002928_abnormal_bile_duct1.16521493
97MP0002210_abnormal_sex_determination1.16179997
98MP0001835_abnormal_antigen_presentation1.16163287
99MP0002429_abnormal_blood_cell1.15368492
100MP0000716_abnormal_immune_system1.14849372
101MP0005058_abnormal_lysosome_morphology1.13739457
102MP0003566_abnormal_cell_adhesion1.13583558
103MP0003984_embryonic_growth_retardation1.13443363
104MP0002088_abnormal_embryonic_growth/wei1.12619995
105MP0001145_abnormal_male_reproductive1.11662568
106MP0000358_abnormal_cell_content/1.10382912
107MP0002452_abnormal_antigen_presenting1.10105127
108MP0002557_abnormal_social/conspecific_i1.09469735
109MP0002723_abnormal_immune_serum1.09393216
110MP0003122_maternal_imprinting1.09241429
111MP0004185_abnormal_adipocyte_glucose1.08524793
112MP0004197_abnormal_fetal_growth/weight/1.08471618
113MP0001485_abnormal_pinna_reflex1.08469265
114MP0000598_abnormal_liver_morphology1.08446883
115MP0003698_abnormal_male_reproductive1.07929741
116MP0006082_CNS_inflammation1.06727861
117MP0003121_genomic_imprinting1.06559392
118MP0005000_abnormal_immune_tolerance1.06059979
119MP0005671_abnormal_response_to1.05950065
120MP0002822_catalepsy1.05664157
121MP0005083_abnormal_biliary_tract1.05483211
122MP0004885_abnormal_endolymph1.05067397
123MP0004147_increased_porphyrin_level1.04740715
124MP0000383_abnormal_hair_follicle1.04723377
125MP0001986_abnormal_taste_sensitivity1.03903875
126MP0005423_abnormal_somatic_nervous1.03870299
127MP0002277_abnormal_respiratory_mucosa1.03576315
128MP0002420_abnormal_adaptive_immunity1.03551124
129MP0003656_abnormal_erythrocyte_physiolo1.03545999
130MP0010155_abnormal_intestine_physiology1.03160747
131MP0008932_abnormal_embryonic_tissue1.02520887
132MP0003878_abnormal_ear_physiology1.02331567
133MP0005377_hearing/vestibular/ear_phenot1.02331567
134MP0001819_abnormal_immune_cell1.01281821
135MP0005499_abnormal_olfactory_system1.01254550
136MP0005394_taste/olfaction_phenotype1.01254550
137MP0002095_abnormal_skin_pigmentation1.00034711
138MP0004043_abnormal_pH_regulation0.99875902
139MP0005319_abnormal_enzyme/_coenzyme0.99223885
140MP0002638_abnormal_pupillary_reflex0.98889220
141MP0000647_abnormal_sebaceous_gland0.98671883
142MP0005464_abnormal_platelet_physiology0.98536090
143MP0003448_altered_tumor_morphology0.98527653
144MP0002084_abnormal_developmental_patter0.98446975
145MP0005220_abnormal_exocrine_pancreas0.97780650
146MP0002085_abnormal_embryonic_tissue0.97059535
147MP0002572_abnormal_emotion/affect_behav0.96681410
148MP0004924_abnormal_behavior0.96194504
149MP0005386_behavior/neurological_phenoty0.96194504
150MP0003191_abnormal_cellular_cholesterol0.95814762
151MP0003186_abnormal_redox_activity0.95329060
152MP0003937_abnormal_limbs/digits/tail_de0.95157457
153MP0008007_abnormal_cellular_replicative0.94767520
154MP0003786_premature_aging0.94676891
155MP0001845_abnormal_inflammatory_respons0.93816380
156MP0001486_abnormal_startle_reflex0.93157085
157MP0002184_abnormal_innervation0.92317606
158MP0006036_abnormal_mitochondrial_physio0.92091092
159MP0003221_abnormal_cardiomyocyte_apopto0.91645448
160MP0002735_abnormal_chemical_nociception0.91438387
161MP0005025_abnormal_response_to0.90422644
162MP0000569_abnormal_digit_pigmentation0.89838629
163MP0000049_abnormal_middle_ear0.89283607
164MP0005367_renal/urinary_system_phenotyp0.88550322
165MP0000516_abnormal_urinary_system0.88550322
166MP0005195_abnormal_posterior_eye0.88537590
167MP0001324_abnormal_eye_pigmentation0.87094986
168MP0002653_abnormal_ependyma_morphology0.85496242
169MP0000653_abnormal_sex_gland0.84924590
170MP0005332_abnormal_amino_acid0.84536932
171MP0009115_abnormal_fat_cell0.83503416
172MP0002970_abnormal_white_adipose0.83427988
173MP0003119_abnormal_digestive_system0.83335513
174MP0001293_anophthalmia0.83254072
175MP0004947_skin_inflammation0.82707547
176MP0005023_abnormal_wound_healing0.82279865
177MP0002751_abnormal_autonomic_nervous0.81808555
178MP0005174_abnormal_tail_pigmentation0.81730801
179MP0005075_abnormal_melanosome_morpholog0.81654407
180MP0005387_immune_system_phenotype0.81626985
181MP0001790_abnormal_immune_system0.81626985
182MP0001348_abnormal_lacrimal_gland0.81588223
183MP0002733_abnormal_thermal_nociception0.81420314
184MP0001944_abnormal_pancreas_morphology0.81375171
185MP0002161_abnormal_fertility/fecundity0.80048772
186MP0008775_abnormal_heart_ventricle0.77279653

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)5.13158465
2Pancreatic cysts (HP:0001737)4.29236627
3Abnormality of the nasal mucosa (HP:0000433)4.16323521
4Pancreatic fibrosis (HP:0100732)3.95017177
5True hermaphroditism (HP:0010459)3.72587023
6Abnormality of midbrain morphology (HP:0002418)3.70845072
7Molar tooth sign on MRI (HP:0002419)3.70845072
8Congenital stationary night blindness (HP:0007642)3.51789211
9Hypoplasia of the pons (HP:0012110)3.27471439
10Abnormality of cells of the erythroid lineage (HP:0012130)3.26310879
11Abnormality of the pons (HP:0007361)3.23913616
12Nephronophthisis (HP:0000090)3.23336903
13Hypochromic anemia (HP:0001931)3.20396871
14Multiple enchondromatosis (HP:0005701)3.17554551
15Abnormal number of erythroid precursors (HP:0012131)3.08249558
16Progressive muscle weakness (HP:0003323)3.04879039
17Pendular nystagmus (HP:0012043)2.98124605
18Type II lissencephaly (HP:0007260)2.89516828
19Basal cell carcinoma (HP:0002671)2.89451356
20Abnormality of alanine metabolism (HP:0010916)2.86439579
21Hyperalaninemia (HP:0003348)2.86439579
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.86439579
23Acute necrotizing encephalopathy (HP:0006965)2.83521454
24Thrombocytosis (HP:0001894)2.82584978
25Attenuation of retinal blood vessels (HP:0007843)2.80652811
26Abnormality of the renal medulla (HP:0100957)2.77215808
27Abnormality of the anterior horn cell (HP:0006802)2.76934823
28Degeneration of anterior horn cells (HP:0002398)2.76934823
29Abnormality of the renal cortex (HP:0011035)2.76784539
30Increased CSF lactate (HP:0002490)2.73480774
31Mitochondrial inheritance (HP:0001427)2.73036267
32Recurrent bronchitis (HP:0002837)2.72892328
33Rectal prolapse (HP:0002035)2.70643472
34Medial flaring of the eyebrow (HP:0010747)2.69432045
35Lipid accumulation in hepatocytes (HP:0006561)2.68108053
36Protrusio acetabuli (HP:0003179)2.64968389
37Acute encephalopathy (HP:0006846)2.64781369
38Abnormal rod and cone electroretinograms (HP:0008323)2.64740715
39Bronchitis (HP:0012387)2.57927291
40Abnormal mitochondria in muscle tissue (HP:0008316)2.55151032
41Genu recurvatum (HP:0002816)2.54967465
42Cystic liver disease (HP:0006706)2.54949326
43Achilles tendon contracture (HP:0001771)2.52944729
44Abnormality of the Achilles tendon (HP:0005109)2.52758516
45Myocardial infarction (HP:0001658)2.51556499
46Abnormal drinking behavior (HP:0030082)2.50998340
47Polydipsia (HP:0001959)2.50998340
48Pustule (HP:0200039)2.50027275
49Tubular atrophy (HP:0000092)2.46752879
50Male infertility (HP:0003251)2.46158791
51Poikiloderma (HP:0001029)2.43913413
523-Methylglutaconic aciduria (HP:0003535)2.39768485
53Sclerocornea (HP:0000647)2.39233271
54Increased hepatocellular lipid droplets (HP:0006565)2.38710408
55Hyperglycinemia (HP:0002154)2.38527551
56Facial hemangioma (HP:0000329)2.38366917
57Abnormality of aromatic amino acid family metabolism (HP:0004338)2.36882015
58Chronic hepatic failure (HP:0100626)2.36577362
59Large for gestational age (HP:0001520)2.35699836
60Chronic bronchitis (HP:0004469)2.35479736
61Squamous cell carcinoma (HP:0002860)2.34802396
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.34684611
63Progressive macrocephaly (HP:0004481)2.34123540
64Increased serum lactate (HP:0002151)2.33943038
65Carpal bone hypoplasia (HP:0001498)2.33589694
66Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.33235544
67Sparse lateral eyebrow (HP:0005338)2.31544493
68Abnormal hemoglobin (HP:0011902)2.31500969
69Aplasia/Hypoplasia of the tongue (HP:0010295)2.29474588
70Microretrognathia (HP:0000308)2.29240179
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.28950551
72Abnormal protein N-linked glycosylation (HP:0012347)2.28950551
73Abnormal protein glycosylation (HP:0012346)2.28950551
74Abnormal glycosylation (HP:0012345)2.28950551
75Macrocytic anemia (HP:0001972)2.27781682
76Impulsivity (HP:0100710)2.27612864
77Abolished electroretinogram (ERG) (HP:0000550)2.24560642
78Lissencephaly (HP:0001339)2.24557810
79Entropion (HP:0000621)2.23856705
80Anencephaly (HP:0002323)2.22579477
81Reticulocytopenia (HP:0001896)2.22371714
82Abnormal cartilage morphology (HP:0002763)2.22063218
83Polycythemia (HP:0001901)2.21481912
84Aplasia/Hypoplasia of the uvula (HP:0010293)2.20996748
85Gait imbalance (HP:0002141)2.20590338
86Hepatocellular necrosis (HP:0001404)2.19790799
87Abnormality of T cell physiology (HP:0011840)2.19433771
88Increased corneal curvature (HP:0100692)2.18593207
89Keratoconus (HP:0000563)2.18593207
90Absent thumb (HP:0009777)2.18252855
91Cerebellar dysplasia (HP:0007033)2.16737796
92Pallor (HP:0000980)2.16615408
93Inability to walk (HP:0002540)2.16610261
94Atrophy/Degeneration involving motor neurons (HP:0007373)2.16435891
95Congenital primary aphakia (HP:0007707)2.15687308
96Nephrogenic diabetes insipidus (HP:0009806)2.15442600
97Absent rod-and cone-mediated responses on ERG (HP:0007688)2.13705847
98Gastrointestinal inflammation (HP:0004386)2.12989080
99Progressive inability to walk (HP:0002505)2.12936500
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.11283448
101Hepatic necrosis (HP:0002605)2.10879088
102Personality changes (HP:0000751)2.09347494
103Hyperventilation (HP:0002883)2.09159955
104Abnormal biliary tract physiology (HP:0012439)2.08911062
105Bile duct proliferation (HP:0001408)2.08911062
106Xanthomatosis (HP:0000991)2.08266733
107Dynein arm defect of respiratory motile cilia (HP:0012255)2.07202424
108Absent/shortened dynein arms (HP:0200106)2.07202424
109Tongue fasciculations (HP:0001308)2.07004555
110Trismus (HP:0000211)2.06409217
111Progressive microcephaly (HP:0000253)2.06389751
112Abnormality of monocarboxylic acid metabolism (HP:0010996)2.06039918
113Male pseudohermaphroditism (HP:0000037)2.05829543
114Rhinitis (HP:0012384)2.05691552
115Polyuria (HP:0000103)2.04702407
116Hypobetalipoproteinemia (HP:0003563)2.03826378
117Breast hypoplasia (HP:0003187)2.03482133
118Increased serum ferritin (HP:0003281)2.03404568
119Abnormality of the ileum (HP:0001549)2.03390475
120Type I transferrin isoform profile (HP:0003642)2.01952681
121Optic disc pallor (HP:0000543)2.01333128
122Difficulty climbing stairs (HP:0003551)2.00771699
123Angiofibromas (HP:0010615)1.99819901
124Adenoma sebaceum (HP:0009720)1.99819901
125Abnormality of the labia minora (HP:0012880)1.99091137
126Dyskinesia (HP:0100660)1.98216837
127Recurrent fungal infections (HP:0002841)1.97954951
128Colitis (HP:0002583)1.97613854
129Bony spicule pigmentary retinopathy (HP:0007737)1.97590072
130Ketosis (HP:0001946)1.96766079
131Abnormality of the motor neurons (HP:0002450)1.96760600
132Abnormal neuron morphology (HP:0012757)1.96760600
133Gastrointestinal infarctions (HP:0005244)1.96573560
134Global brain atrophy (HP:0002283)1.96483133
135Inflammation of the large intestine (HP:0002037)1.96351763
136Abnormality of reticulocytes (HP:0004312)1.96271689
137Rhabdomyosarcoma (HP:0002859)1.96093687
138Severe muscular hypotonia (HP:0006829)1.95645785
139Furrowed tongue (HP:0000221)1.95390411
140Aplasia/Hypoplasia of the tibia (HP:0005772)1.94731737
141Cerebral aneurysm (HP:0004944)1.94365946
142Infertility (HP:0000789)1.94288254
143Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93738208
144Selective tooth agenesis (HP:0001592)1.93175296
145Abnormal respiratory motile cilium morphology (HP:0005938)1.92209027
146Abnormal respiratory epithelium morphology (HP:0012253)1.92209027
147Renal Fanconi syndrome (HP:0001994)1.90647186
148Muscle fibrillation (HP:0010546)1.89366713
149Congenital hepatic fibrosis (HP:0002612)1.89054218
150Lactic acidosis (HP:0003128)1.88954133
151Abnormality of T cells (HP:0002843)1.87597968
152Severe visual impairment (HP:0001141)1.86613107
153Meckel diverticulum (HP:0002245)1.86376836
154Methylmalonic acidemia (HP:0002912)1.85525927
155Cerebral edema (HP:0002181)1.84452415
156Congenital, generalized hypertrichosis (HP:0004540)1.84002013
157Abnormality of the distal phalanges of the toes (HP:0010182)1.83833857
158Aplasia/Hypoplasia of the patella (HP:0006498)1.83587653
159Abnormal platelet function (HP:0011869)1.82377910
160Impaired platelet aggregation (HP:0003540)1.82377910
161Renal cortical cysts (HP:0000803)1.81763855
162Reticulocytosis (HP:0001923)1.81590425
163Birth length less than 3rd percentile (HP:0003561)1.81398954
164Ulnar deviation of the wrist (HP:0003049)1.81280505
165Chronic otitis media (HP:0000389)1.81197241
166Poor suck (HP:0002033)1.80997329
167Ketoacidosis (HP:0001993)1.80757079
168Missing ribs (HP:0000921)1.80700376
169Amyotrophic lateral sclerosis (HP:0007354)1.80491699
170Gaze-evoked nystagmus (HP:0000640)1.79831909
171Joint stiffness (HP:0001387)1.79807970
172Abnormality of the lower motor neuron (HP:0002366)1.79112791
173Genital tract atresia (HP:0001827)1.78814130
174Hyperglycinuria (HP:0003108)1.78565111
175Decreased central vision (HP:0007663)1.78108106
176Patellar aplasia (HP:0006443)1.78027431
177Abnormal delayed hypersensitivity skin test (HP:0002963)1.76795050
178Vaginal atresia (HP:0000148)1.75769801
179Hand muscle atrophy (HP:0009130)1.75739301
180Breech presentation (HP:0001623)1.75157306
181Recurrent sinusitis (HP:0011108)1.74836474
182Recurrent viral infections (HP:0004429)1.74579766
183Bronchiectasis (HP:0002110)1.74088513
184Cleft eyelid (HP:0000625)1.73585745
185Abnormal spermatogenesis (HP:0008669)1.72278644
186Prominent nose (HP:0000448)1.72167384
187Rough bone trabeculation (HP:0100670)1.72130505
188Aplasia/hypoplasia of the humerus (HP:0006507)1.72076948
189Microcytic anemia (HP:0001935)1.70544585
190Abnormality of iron homeostasis (HP:0011031)1.69959813
191Abnormality of transition element cation homeostasis (HP:0011030)1.69601847
192Concave nail (HP:0001598)1.69419865
19311 pairs of ribs (HP:0000878)1.68961291
194Thoracolumbar scoliosis (HP:0002944)1.68110921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.72049466
2ZAK3.99864431
3NME23.14156279
4ADRBK23.13050466
5MAP3K103.03385742
6BMPR1B2.89535374
7TRIB32.74840314
8NEK22.62192980
9EEF2K2.47103971
10WEE12.40219660
11MAP4K22.35347073
12PKN22.34776500
13MAP3K112.32090412
14TRIM282.27863014
15MAP4K12.22188025
16WNK32.19804871
17GRK12.17922963
18ICK2.15496969
19TLK12.14342249
20NUAK12.13212454
21EIF2AK12.09326956
22VRK22.03860955
23PINK12.03628410
24ERN12.00862582
25WNK41.97839766
26DYRK31.95087573
27BUB11.87242297
28INSRR1.84043579
29BCKDK1.82150788
30VRK11.77303185
31GRK61.67606832
32PDK41.66520056
33PDK31.66520056
34TNIK1.64523839
35TAF11.63004861
36CDK121.61467981
37PIM21.59313602
38TESK11.53048768
39RPS6KA41.48065029
40TESK21.47580944
41CDK41.45913331
42CDC71.45533669
43PRKCI1.44387516
44LIMK11.37505492
45PIM11.35248064
46STK161.33108698
47MAPK131.32415840
48SCYL21.31247247
49MAP3K31.30500917
50OXSR11.30419615
51MAPK151.29593068
52NME11.29319203
53ACVR1B1.26966681
54TAOK31.26161450
55CDK71.23222250
56DYRK21.22813820
57ALK1.22772049
58MAPKAPK31.21953770
59STK101.19389534
60TAOK11.19343376
61PLK41.19115098
62STK31.17230019
63CSK1.15792251
64PRKCG1.15538737
65DYRK1B1.15383100
66CSNK1G11.14386716
67STK38L1.13049498
68MKNK21.12173855
69STK391.10185244
70MAP2K71.09604824
71MATK1.09597290
72MAP3K41.07956413
73PAK41.04479519
74FLT31.03561124
75RPS6KA51.03188805
76ZAP701.01858551
77ADRBK11.01746503
78DDR21.00990069
79MAP2K21.00056723
80AKT30.98997172
81CSNK1G30.97893950
82LATS20.94686187
83TSSK60.94634127
84NLK0.94147381
85CASK0.93873791
86EIF2AK30.93392398
87MAP3K80.92958020
88PLK10.92944959
89PASK0.92897630
90MST40.91908814
91PRKCE0.90529021
92TTK0.89117502
93CHEK20.87555792
94CSNK1A1L0.86400604
95CSNK1G20.83879640
96BLK0.82901744
97MAPK110.82459299
98CDK60.81817670
99BCR0.81669994
100BRSK20.81628105
101RPS6KB20.81430321
102PLK30.80606908
103PRKD30.80574629
104LRRK20.80158292
105TGFBR10.79668402
106TYK20.79666155
107MAP3K60.78455853
108TBK10.77167234
109MAP2K30.74420410
110PDK20.72732300
111TYRO30.69478462
112MUSK0.69476921
113PDGFRA0.68841858
114MTOR0.67041606
115AURKA0.66660790
116PRKD20.65328197
117AURKB0.64411761
118MAP2K60.64303384
119EPHA20.63997588
120PAK20.62880134
121HIPK20.60878126
122PHKG20.60266701
123PHKG10.60266701
124TXK0.60176161
125KDR0.60086500
126JAK30.59771962
127PLK20.58774801
128PAK30.58713151
129PNCK0.58560825
130CSNK1A10.57997461
131MAPKAPK50.57921111
132MKNK10.54653030
133PRKCQ0.54591078
134NEK10.53601399
135IKBKB0.53537255
136BMX0.53236655
137RPS6KA10.52083120
138CDK20.51349100
139PDK10.51299708
140FES0.50948105
141GSK3A0.50493631
142CHEK10.50438867
143TIE10.50278199
144PKN10.49694698
145STK40.49057165
146PTK2B0.48659027
147BTK0.48074707
148ATR0.47844073
149MAPK40.47128494
150MARK30.45821897
151ERBB30.45589069
152HCK0.45144843
153SRPK10.44873214
154SIK20.44850461
155CAMKK20.44619039
156DAPK30.43877103
157PAK10.43183803
158LCK0.42799260
159CSNK2A20.42708814
160MAP3K50.42614049
161FGFR30.41587502
162CSF1R0.41238600
163SIK10.41148768
164JAK20.40729579
165PIK3CA0.40641763
166CSNK2A10.40346261
167DAPK10.38927629
168IRAK40.37539003
169PRKCZ0.37103644
170ABL20.36377979
171EIF2AK20.34898149
172CSNK1D0.32978591
173PRKACA0.28611476
174TEC0.28193104
175MAP2K10.28000034
176PBK0.25469336
177PRKCA0.24786522

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.36459942
2Ribosome_Homo sapiens_hsa030103.13362230
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07215152
4Oxidative phosphorylation_Homo sapiens_hsa001902.77133989
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.66268402
6Mismatch repair_Homo sapiens_hsa034302.63021890
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.59851252
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47326084
9One carbon pool by folate_Homo sapiens_hsa006702.46827658
10RNA transport_Homo sapiens_hsa030132.46804970
11Base excision repair_Homo sapiens_hsa034102.38386318
12Butanoate metabolism_Homo sapiens_hsa006502.31453753
13Selenocompound metabolism_Homo sapiens_hsa004502.20839569
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.20510044
15Parkinsons disease_Homo sapiens_hsa050122.12790543
16Phototransduction_Homo sapiens_hsa047442.11532152
17* Sulfur relay system_Homo sapiens_hsa041222.11369747
18Spliceosome_Homo sapiens_hsa030402.02648690
19Pentose phosphate pathway_Homo sapiens_hsa000302.02465427
20Protein export_Homo sapiens_hsa030602.00347152
21Folate biosynthesis_Homo sapiens_hsa007901.94239380
22Antigen processing and presentation_Homo sapiens_hsa046121.91538008
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87386973
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78355577
25Biosynthesis of amino acids_Homo sapiens_hsa012301.78110612
26Linoleic acid metabolism_Homo sapiens_hsa005911.72496644
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65819272
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63309594
29Pyrimidine metabolism_Homo sapiens_hsa002401.58032889
30RNA polymerase_Homo sapiens_hsa030201.56334480
31Huntingtons disease_Homo sapiens_hsa050161.55547229
32Cell cycle_Homo sapiens_hsa041101.54486995
33Vitamin B6 metabolism_Homo sapiens_hsa007501.53556687
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51883685
35Nucleotide excision repair_Homo sapiens_hsa034201.50894117
36Tryptophan metabolism_Homo sapiens_hsa003801.47335869
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44185611
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43127106
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42635384
40Alzheimers disease_Homo sapiens_hsa050101.41024569
41Nicotine addiction_Homo sapiens_hsa050331.40906184
42Proteasome_Homo sapiens_hsa030501.39292610
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.38521352
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37325749
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35666766
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33586896
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30453396
48p53 signaling pathway_Homo sapiens_hsa041151.30040006
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27451187
50Propanoate metabolism_Homo sapiens_hsa006401.26663049
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26098704
52Primary immunodeficiency_Homo sapiens_hsa053401.22304636
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.21670461
54Peroxisome_Homo sapiens_hsa041461.21623658
55Fructose and mannose metabolism_Homo sapiens_hsa000511.17871467
56Fatty acid elongation_Homo sapiens_hsa000621.17305991
57mRNA surveillance pathway_Homo sapiens_hsa030151.17135822
58Carbon metabolism_Homo sapiens_hsa012001.15546119
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14778377
60Thyroid cancer_Homo sapiens_hsa052161.13615852
61Sulfur metabolism_Homo sapiens_hsa009201.13009941
62Ether lipid metabolism_Homo sapiens_hsa005651.11343812
63Herpes simplex infection_Homo sapiens_hsa051681.10973153
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10690306
65Caffeine metabolism_Homo sapiens_hsa002321.08879163
66Olfactory transduction_Homo sapiens_hsa047401.06750510
67Homologous recombination_Homo sapiens_hsa034401.06533536
68Taste transduction_Homo sapiens_hsa047421.06471411
69Steroid biosynthesis_Homo sapiens_hsa001001.05213636
70Cardiac muscle contraction_Homo sapiens_hsa042601.04142175
71Acute myeloid leukemia_Homo sapiens_hsa052211.03710597
72B cell receptor signaling pathway_Homo sapiens_hsa046621.03424231
73Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02957837
74Bladder cancer_Homo sapiens_hsa052191.02400250
75Regulation of autophagy_Homo sapiens_hsa041401.00907097
76Galactose metabolism_Homo sapiens_hsa000520.99934862
77mTOR signaling pathway_Homo sapiens_hsa041500.99666463
78Legionellosis_Homo sapiens_hsa051340.97150206
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95108253
80Chemical carcinogenesis_Homo sapiens_hsa052040.94745766
81Metabolic pathways_Homo sapiens_hsa011000.91483339
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.91269142
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.89406029
84Viral carcinogenesis_Homo sapiens_hsa052030.88677759
85beta-Alanine metabolism_Homo sapiens_hsa004100.86985964
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.83279635
87Epstein-Barr virus infection_Homo sapiens_hsa051690.82783395
88Systemic lupus erythematosus_Homo sapiens_hsa053220.82590263
89Arginine biosynthesis_Homo sapiens_hsa002200.80259719
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79428389
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.79134544
92Fanconi anemia pathway_Homo sapiens_hsa034600.78066740
93Chronic myeloid leukemia_Homo sapiens_hsa052200.76878714
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76256680
95Collecting duct acid secretion_Homo sapiens_hsa049660.76121263
96Basal transcription factors_Homo sapiens_hsa030220.74818120
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73675431
98Nitrogen metabolism_Homo sapiens_hsa009100.73383159
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73305094
100Fatty acid biosynthesis_Homo sapiens_hsa000610.72697776
101Measles_Homo sapiens_hsa051620.72019705
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71983165
103Fat digestion and absorption_Homo sapiens_hsa049750.71421732
104RNA degradation_Homo sapiens_hsa030180.71379634
105Tyrosine metabolism_Homo sapiens_hsa003500.70231016
106HTLV-I infection_Homo sapiens_hsa051660.65735479
107Apoptosis_Homo sapiens_hsa042100.65371211
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65235097
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64702872
110Retinol metabolism_Homo sapiens_hsa008300.64235546
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62114910
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61165491
113Hepatitis B_Homo sapiens_hsa051610.61066168
114Morphine addiction_Homo sapiens_hsa050320.60591821
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59669675
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56437920
117Oocyte meiosis_Homo sapiens_hsa041140.55126843
118Osteoclast differentiation_Homo sapiens_hsa043800.54861807
119Arginine and proline metabolism_Homo sapiens_hsa003300.53808277
120AMPK signaling pathway_Homo sapiens_hsa041520.51778253
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.51691073
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51320838
123Glutathione metabolism_Homo sapiens_hsa004800.50926574
124Arachidonic acid metabolism_Homo sapiens_hsa005900.50902838
125VEGF signaling pathway_Homo sapiens_hsa043700.50041565
126Serotonergic synapse_Homo sapiens_hsa047260.49549392
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49403912
128Shigellosis_Homo sapiens_hsa051310.48891216
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.48753832
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48030786
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47852612
132ABC transporters_Homo sapiens_hsa020100.47624742
133Alcoholism_Homo sapiens_hsa050340.47564411
134HIF-1 signaling pathway_Homo sapiens_hsa040660.47456195
135Small cell lung cancer_Homo sapiens_hsa052220.47452090
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44585704
137Glycerolipid metabolism_Homo sapiens_hsa005610.44424701
138Leishmaniasis_Homo sapiens_hsa051400.43739227
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.43288494
140Ovarian steroidogenesis_Homo sapiens_hsa049130.43261255
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42814710
142Maturity onset diabetes of the young_Homo sapiens_hsa049500.42096492
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41507849
144Purine metabolism_Homo sapiens_hsa002300.41491217
145T cell receptor signaling pathway_Homo sapiens_hsa046600.41453255
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40615925
147Fatty acid metabolism_Homo sapiens_hsa012120.40488092
148NF-kappa B signaling pathway_Homo sapiens_hsa040640.39713735
149Glucagon signaling pathway_Homo sapiens_hsa049220.39410515
150GABAergic synapse_Homo sapiens_hsa047270.39081685
151Glycosaminoglycan degradation_Homo sapiens_hsa005310.38229215
152Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37735022
153Other glycan degradation_Homo sapiens_hsa005110.37148181
154N-Glycan biosynthesis_Homo sapiens_hsa005100.36510399
155Insulin signaling pathway_Homo sapiens_hsa049100.36244275
156Starch and sucrose metabolism_Homo sapiens_hsa005000.35468019
157Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34560754
158Non-homologous end-joining_Homo sapiens_hsa034500.33839425
159Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33346153
160Hedgehog signaling pathway_Homo sapiens_hsa043400.30369836

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