MOGAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerols, the precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 [PubMed 12077311]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)8.68958667
2urate metabolic process (GO:0046415)8.59964649
3aminoglycoside antibiotic metabolic process (GO:0030647)7.43228464
4low-density lipoprotein particle clearance (GO:0034383)7.32579875
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)7.15025404
6drug transport (GO:0015893)7.11121960
7lysine metabolic process (GO:0006553)6.93138401
8lysine catabolic process (GO:0006554)6.93138401
9glyoxylate metabolic process (GO:0046487)6.63629815
10phospholipid homeostasis (GO:0055091)6.58085101
11drug catabolic process (GO:0042737)6.47199396
12phosphate ion transport (GO:0006817)6.41495950
13organic cation transport (GO:0015695)6.40424227
14exogenous drug catabolic process (GO:0042738)6.26650936
15cysteine metabolic process (GO:0006534)6.05404317
16quaternary ammonium group transport (GO:0015697)5.89739953
17triglyceride catabolic process (GO:0019433)5.87849839
18acylglycerol catabolic process (GO:0046464)5.62958612
19neutral lipid catabolic process (GO:0046461)5.62958612
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.62546316
21L-phenylalanine catabolic process (GO:0006559)5.62546316
22short-chain fatty acid metabolic process (GO:0046459)5.59714435
23regulation of protein activation cascade (GO:2000257)5.58306549
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.56907893
25phosphate ion transmembrane transport (GO:0035435)5.56740127
26L-phenylalanine metabolic process (GO:0006558)5.54648795
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.54648795
28fatty acid homeostasis (GO:0055089)5.50282766
29complement activation, alternative pathway (GO:0006957)5.49583798
30plasma lipoprotein particle clearance (GO:0034381)5.48472400
31regulation of complement activation (GO:0030449)5.43694547
32branched-chain amino acid metabolic process (GO:0009081)5.34342521
33low-density lipoprotein particle remodeling (GO:0034374)5.31617253
34negative regulation of fibrinolysis (GO:0051918)5.30483119
35tricarboxylic acid metabolic process (GO:0072350)5.27522755
36valine metabolic process (GO:0006573)5.25611845
37triglyceride homeostasis (GO:0070328)5.13608611
38acylglycerol homeostasis (GO:0055090)5.13608611
39protein-lipid complex remodeling (GO:0034368)5.03899444
40macromolecular complex remodeling (GO:0034367)5.03899444
41plasma lipoprotein particle remodeling (GO:0034369)5.03899444
42aromatic amino acid family catabolic process (GO:0009074)4.94339468
43response to mercury ion (GO:0046689)4.92132291
44aspartate family amino acid catabolic process (GO:0009068)4.90254138
45fatty acid beta-oxidation (GO:0006635)4.89110972
46regulation of fibrinolysis (GO:0051917)4.88834905
47high-density lipoprotein particle remodeling (GO:0034375)4.87588467
48amino-acid betaine metabolic process (GO:0006577)4.77734474
49branched-chain amino acid catabolic process (GO:0009083)4.74455652
50serine family amino acid catabolic process (GO:0009071)4.71862888
51nonribosomal peptide biosynthetic process (GO:0019184)4.69326661
52regulation of sequestering of triglyceride (GO:0010889)4.64670292
53carnitine transport (GO:0015879)4.58075289
54amino-acid betaine transport (GO:0015838)4.58075289
55fatty acid oxidation (GO:0019395)4.54797692
56* diacylglycerol metabolic process (GO:0046339)4.49994222
57lipid oxidation (GO:0034440)4.49024427
58homocysteine metabolic process (GO:0050667)4.43642470
59very-low-density lipoprotein particle assembly (GO:0034379)4.39341643
60fatty-acyl-CoA metabolic process (GO:0035337)4.39266247
61fatty-acyl-CoA biosynthetic process (GO:0046949)4.39255316
62acetyl-CoA metabolic process (GO:0006084)4.37458694
63biotin metabolic process (GO:0006768)4.37340697
64serine family amino acid metabolic process (GO:0009069)4.34347269
65cellular ketone body metabolic process (GO:0046950)4.34188736
66sulfur amino acid catabolic process (GO:0000098)4.33821168
67carnitine metabolic process (GO:0009437)4.32433259
68peptidyl-glutamic acid carboxylation (GO:0017187)4.31794813
69protein carboxylation (GO:0018214)4.31794813
70indolalkylamine catabolic process (GO:0046218)4.30976598
71tryptophan catabolic process (GO:0006569)4.30976598
72indole-containing compound catabolic process (GO:0042436)4.30976598
73* triglyceride metabolic process (GO:0006641)4.29266630
74glutathione biosynthetic process (GO:0006750)4.28027904
75cellular modified amino acid catabolic process (GO:0042219)4.27791627
76plasma lipoprotein particle organization (GO:0071827)4.25751976
772-oxoglutarate metabolic process (GO:0006103)4.25643837
78acyl-CoA biosynthetic process (GO:0071616)4.24720307
79thioester biosynthetic process (GO:0035384)4.24720307
80negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.24705194
81reverse cholesterol transport (GO:0043691)4.23846790
82fatty acid catabolic process (GO:0009062)4.21626632
83epoxygenase P450 pathway (GO:0019373)4.20754439
84fatty acid transmembrane transport (GO:1902001)4.17765170
85omega-hydroxylase P450 pathway (GO:0097267)4.16015975
86excretion (GO:0007588)4.15805498
87negative regulation of lipase activity (GO:0060192)4.15778747
88brown fat cell differentiation (GO:0050873)4.11980678
89vitamin D metabolic process (GO:0042359)4.11912679
90tryptophan metabolic process (GO:0006568)4.11589758
91* acylglycerol metabolic process (GO:0006639)4.10650585
92regulation of cholesterol storage (GO:0010885)4.07857670
93* triglyceride biosynthetic process (GO:0019432)4.06619045
94glycerolipid catabolic process (GO:0046503)4.06174980
95cholesterol efflux (GO:0033344)4.04930950
96* neutral lipid metabolic process (GO:0006638)4.04609878
97* acylglycerol biosynthetic process (GO:0046463)4.04110551
98* neutral lipid biosynthetic process (GO:0046460)4.04110551
99regulation of cholesterol esterification (GO:0010872)4.04080590
100positive regulation of lipid storage (GO:0010884)4.02714189
101protein-lipid complex subunit organization (GO:0071825)4.00484090
102glutathione derivative biosynthetic process (GO:1901687)3.99430796
103glutathione derivative metabolic process (GO:1901685)3.99430796
104cellular amino acid catabolic process (GO:0009063)3.99138464
105monocarboxylic acid catabolic process (GO:0072329)3.94505860
106urea metabolic process (GO:0019627)3.92337797
107alpha-amino acid catabolic process (GO:1901606)3.91831348
108fructose metabolic process (GO:0006000)3.90533236
109plasma lipoprotein particle assembly (GO:0034377)3.90001014
110long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.84747399
111toxin transport (GO:1901998)3.83524369
112regulation of apoptotic cell clearance (GO:2000425)3.82695234
113acyl-CoA metabolic process (GO:0006637)3.81987864
114thioester metabolic process (GO:0035383)3.81987864
115glutathione metabolic process (GO:0006749)3.79746611
116blood coagulation, intrinsic pathway (GO:0007597)3.79439897
117organic acid catabolic process (GO:0016054)3.78661794
118carboxylic acid catabolic process (GO:0046395)3.78661794
119ketone body metabolic process (GO:1902224)3.76548900
120intestinal cholesterol absorption (GO:0030299)3.75990051
121drug metabolic process (GO:0017144)3.75928489
122glutamate metabolic process (GO:0006536)3.72991962
123renal absorption (GO:0070293)3.72518742
124negative regulation of sterol transport (GO:0032372)3.70800244
125negative regulation of cholesterol transport (GO:0032375)3.70800244
126regulation of triglyceride catabolic process (GO:0010896)3.70631005
127carnitine shuttle (GO:0006853)3.69893942
128proline metabolic process (GO:0006560)3.68170957
129alpha-linolenic acid metabolic process (GO:0036109)3.64469236
130aromatic amino acid family metabolic process (GO:0009072)3.64107124
131uronic acid metabolic process (GO:0006063)3.61723001
132glucuronate metabolic process (GO:0019585)3.61723001
133negative regulation of protein activation cascade (GO:2000258)3.60424682
134long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.60360433
135NADH metabolic process (GO:0006734)3.60345386
136urea cycle (GO:0000050)3.56930088
137serine family amino acid biosynthetic process (GO:0009070)3.54920431
138metanephric tubule development (GO:0072170)3.54895342
139metanephric nephron tubule development (GO:0072234)3.54895342
140trivalent inorganic anion homeostasis (GO:0072506)3.53835325
141phosphate ion homeostasis (GO:0055062)3.53835325
142cholesterol homeostasis (GO:0042632)3.52392007
143bile acid biosynthetic process (GO:0006699)3.50421820
144acute-phase response (GO:0006953)3.50286968
145lipoprotein metabolic process (GO:0042157)3.49982383
146NADP metabolic process (GO:0006739)3.49900026
147positive regulation of triglyceride lipase activity (GO:0061365)3.48574322
148positive regulation of lipoprotein lipase activity (GO:0051006)3.48574322
149protein-lipid complex assembly (GO:0065005)3.47648887
150phospholipid efflux (GO:0033700)3.47542748
151cellular glucuronidation (GO:0052695)3.47171244
152nitrogen cycle metabolic process (GO:0071941)3.46758207
153sterol homeostasis (GO:0055092)3.46156220
154flavonoid metabolic process (GO:0009812)3.44749221
155ethanol metabolic process (GO:0006067)3.44485927
156ethanol oxidation (GO:0006069)3.43752331
157regulation of macrophage derived foam cell differentiation (GO:0010743)3.43236744
158glycoside metabolic process (GO:0016137)3.42594240
159peptide biosynthetic process (GO:0043043)3.41934428
160kynurenine metabolic process (GO:0070189)3.40824230
161succinate metabolic process (GO:0006105)3.40343211
162response to phenylpropanoid (GO:0080184)3.38709767
163modified amino acid transport (GO:0072337)3.36367418
164lipid homeostasis (GO:0055088)3.35690744
165alanine transport (GO:0032328)3.34698779
166vitamin transport (GO:0051180)3.34457461
167fibrinolysis (GO:0042730)3.33295227
168L-serine transport (GO:0015825)3.30939159
169heme transport (GO:0015886)3.30777280
170regulation of cholesterol homeostasis (GO:2000188)3.29990246
171small molecule catabolic process (GO:0044282)3.29973651
172protein activation cascade (GO:0072376)3.29055784
173benzene-containing compound metabolic process (GO:0042537)3.27486285
174primary alcohol metabolic process (GO:0034308)3.26356984
175sodium-independent organic anion transport (GO:0043252)3.25246704
176aldehyde catabolic process (GO:0046185)3.24835202
177metanephric nephron epithelium development (GO:0072243)3.24566832
178dicarboxylic acid metabolic process (GO:0043648)3.23939758
179response to growth hormone (GO:0060416)3.22982930
180carnitine transmembrane transport (GO:1902603)3.22834411
181tricarboxylic acid cycle (GO:0006099)3.16134075
182oxaloacetate metabolic process (GO:0006107)3.14142429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.78573182
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.67705580
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.11842025
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.17651776
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.60012599
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.06073999
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.47976215
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.26363867
9* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.08374309
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.89735385
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.69015562
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.64170229
13CLOCK_20551151_ChIP-Seq_293T_Human2.46021200
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.35782386
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.26065177
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.05113924
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.04697208
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.03076713
19PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.97340253
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.95197982
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.88861713
22* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.88454821
23CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.79225495
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66284874
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.64515877
26* FOXA2_19822575_ChIP-Seq_HepG2_Human1.53037324
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52884437
28ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.50003010
29GATA4_25053715_ChIP-Seq_YYC3_Human1.47873560
30ZNF263_19887448_ChIP-Seq_K562_Human1.47642416
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.46469824
32* HNF4A_19822575_ChIP-Seq_HepG2_Human1.45723469
33EGR1_19032775_ChIP-ChIP_M12_Human1.36031773
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.28372296
35AR_21909140_ChIP-Seq_LNCAP_Human1.27244436
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25956990
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25442885
38HTT_18923047_ChIP-ChIP_STHdh_Human1.21355848
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21086543
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17131049
41TCF4_18268006_ChIP-ChIP_LS174T_Human1.16615340
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.16337094
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16046095
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13667778
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13659409
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12408939
47AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11693915
48LXR_22292898_ChIP-Seq_THP-1_Human1.10232901
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.09948423
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08562414
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07318562
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07042507
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.05967861
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05606035
55* GATA2_21666600_ChIP-Seq_HMVEC_Human1.04812826
56VDR_22108803_ChIP-Seq_LS180_Human1.03853870
57SOX2_20726797_ChIP-Seq_SW620_Human1.02305428
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01372346
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01071589
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00351296
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00309202
62SALL1_21062744_ChIP-ChIP_HESCs_Human0.99655808
63TP53_18474530_ChIP-ChIP_U2OS_Human0.97974772
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96615647
65GATA6_25053715_ChIP-Seq_YYC3_Human0.95458510
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95360166
67NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95118895
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94788476
69RACK7_27058665_Chip-Seq_MCF-7_Human0.92402123
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92326406
71TBX20_22080862_ChIP-Seq_HEART_Mouse0.90393405
72TBX20_22328084_ChIP-Seq_HEART_Mouse0.90393405
73IRF8_22096565_ChIP-ChIP_GC-B_Human0.90230746
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90019560
75NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90019560
76RXR_22108803_ChIP-Seq_LS180_Human0.87321602
77SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85480384
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84657856
79STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83556425
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83190307
81NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82733118
82RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81507684
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81313804
84* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80981725
85PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80916206
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80828963
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80151278
88CJUN_26792858_Chip-Seq_BT549_Human0.79706463
89BCAT_22108803_ChIP-Seq_LS180_Human0.79447099
90FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.78835750
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78058336
92GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.77611769
93NFIB_24661679_ChIP-Seq_LUNG_Mouse0.77318265
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.76581184
95ERG_21242973_ChIP-ChIP_JURKAT_Human0.76057519
96CDX2_22108803_ChIP-Seq_LS180_Human0.74638293
97ZNF217_24962896_ChIP-Seq_MCF-7_Human0.74341464
98BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72624117
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.70622036
100MYC_19915707_ChIP-ChIP_AK7_Human0.70567915
101* CEBPB_22108803_ChIP-Seq_LS180_Human0.69536891
102ESR1_15608294_ChIP-ChIP_MCF-7_Human0.69206603
103GATA3_24758297_ChIP-Seq_MCF-7_Human0.67519848
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67491235
105MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.66306861
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.65972309
107TP63_17297297_ChIP-ChIP_HaCaT_Human0.65814339
108* EP300_21415370_ChIP-Seq_HL-1_Mouse0.65226500
109* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.65058258
110P63_26484246_Chip-Seq_KERATINOCYTES_Human0.64875354
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.64710957
112P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.64633104
113CSB_26484114_Chip-Seq_FIBROBLAST_Human0.64610146
114E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.64510558
115* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.64451381
116SOX17_20123909_ChIP-Seq_XEN_Mouse0.64110997
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.64027333
118* SMAD4_21741376_ChIP-Seq_HESCs_Human0.62299536
119* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.62276285
120SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.61050420
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.60734710
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.60499052
123CBP_21632823_ChIP-Seq_H3396_Human0.60333975
124PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.60028736
125AUTS2_25519132_ChIP-Seq_293T-REX_Human0.59959680
126PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.59707094
127AHR_22903824_ChIP-Seq_MCF-7_Human0.59541405
128ZNF274_21170338_ChIP-Seq_K562_Hela0.59108037
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58752071
130GATA2_19941826_ChIP-Seq_K562_Human0.58552434
131TP63_23658742_ChIP-Seq_EP156T_Human0.58398072
132* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.58380814
133SMC4_20622854_ChIP-Seq_HELA_Human0.58335415
134EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.58217707
135VDR_24787735_ChIP-Seq_THP-1_Human0.58142032
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.57421410
137LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.54287921

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.25820085
2MP0002139_abnormal_hepatobiliary_system6.22537406
3MP0004043_abnormal_pH_regulation4.55951028
4MP0005332_abnormal_amino_acid4.43777847
5MP0004019_abnormal_vitamin_homeostasis4.22378082
6MP0008875_abnormal_xenobiotic_pharmacok3.73158690
7MP0005365_abnormal_bile_salt3.70982316
8MP0005085_abnormal_gallbladder_physiolo3.49057400
9MP0009643_abnormal_urine_homeostasis3.22897298
10MP0002138_abnormal_hepatobiliary_system3.18468717
11MP0008004_abnormal_stomach_pH3.07147564
12MP0003195_calcinosis3.00948160
13MP0003806_abnormal_nucleotide_metabolis3.00412988
14MP0001765_abnormal_ion_homeostasis2.75747211
15MP0003252_abnormal_bile_duct2.72502406
16MP0005636_abnormal_mineral_homeostasis2.52971148
17MP0001756_abnormal_urination2.44824495
18MP0003011_delayed_dark_adaptation2.42292283
19MP0002136_abnormal_kidney_physiology2.22399996
20MP0003186_abnormal_redox_activity2.14571515
21MP0005670_abnormal_white_adipose2.10217277
22MP0010329_abnormal_lipoprotein_level2.05900683
23MP0001666_abnormal_nutrient_absorption1.97705303
24MP0003878_abnormal_ear_physiology1.94977959
25MP0005377_hearing/vestibular/ear_phenot1.94977959
26MP0005058_abnormal_lysosome_morphology1.85325894
27MP0005584_abnormal_enzyme/coenzyme_acti1.83963012
28MP0004272_abnormal_basement_membrane1.81851393
29MP0006054_spinal_hemorrhage1.74501715
30MP0001958_emphysema1.72365403
31MP0005666_abnormal_adipose_tissue1.69984408
32MP0002118_abnormal_lipid_homeostasis1.69576975
33MP0002876_abnormal_thyroid_physiology1.66615540
34MP0005448_abnormal_energy_balance1.63463645
35MP0005319_abnormal_enzyme/_coenzyme1.62987833
36MP0003191_abnormal_cellular_cholesterol1.49337088
37MP0005083_abnormal_biliary_tract1.35626142
38MP0005451_abnormal_body_composition1.33643539
39MP0006036_abnormal_mitochondrial_physio1.33294995
40MP0004885_abnormal_endolymph1.33091217
41MP0002254_reproductive_system_inflammat1.31888469
42MP0005167_abnormal_blood-brain_barrier1.27502224
43MP0005535_abnormal_body_temperature1.27379399
44MP0001661_extended_life_span1.24454243
45MP0000609_abnormal_liver_physiology1.23349327
46MP0005084_abnormal_gallbladder_morpholo1.21168344
47MP0010368_abnormal_lymphatic_system1.21063849
48MP0001881_abnormal_mammary_gland1.20702445
49MP0001764_abnormal_homeostasis1.16770006
50MP0005164_abnormal_response_to1.16080916
51MP0003828_pulmonary_edema1.15903125
52MP0002132_abnormal_respiratory_system1.15083552
53MP0008961_abnormal_basal_metabolism1.10456300
54MP0001664_abnormal_digestion1.08648593
55MP0000538_abnormal_urinary_bladder1.07006763
56MP0006138_congestive_heart_failure1.04022889
57MP0001915_intracranial_hemorrhage1.03547187
58MP0000230_abnormal_systemic_arterial0.99867693
59MP0005647_abnormal_sex_gland0.98254953
60MP0002168_other_aberrant_phenotype0.97781564
61MP0003950_abnormal_plasma_membrane0.97196284
62MP0004130_abnormal_muscle_cell0.96788447
63MP0009840_abnormal_foam_cell0.94591324
64MP0003300_gastrointestinal_ulcer0.93717658
65MP0003941_abnormal_skin_development0.93277652
66MP0005375_adipose_tissue_phenotype0.92293579
67MP0004264_abnormal_extraembryonic_tissu0.91487570
68MP0002971_abnormal_brown_adipose0.87665042
69MP0004147_increased_porphyrin_level0.87329044
70MP0009642_abnormal_blood_homeostasis0.86700125
71MP0004883_abnormal_blood_vessel0.85229968
72MP0002078_abnormal_glucose_homeostasis0.81214738
73MP0002837_dystrophic_cardiac_calcinosis0.80271219
74MP0002928_abnormal_bile_duct0.78718402
75MP0000003_abnormal_adipose_tissue0.77555178
76MP0009763_increased_sensitivity_to0.76413839
77MP0002796_impaired_skin_barrier0.76042824
78MP0000598_abnormal_liver_morphology0.75988660
79MP0003959_abnormal_lean_body0.75178694
80MP0009764_decreased_sensitivity_to0.75038598
81MP0003638_abnormal_response/metabolism_0.73703085
82MP0003633_abnormal_nervous_system0.73535610
83MP0003690_abnormal_glial_cell0.72572756
84MP0002135_abnormal_kidney_morphology0.71682548
85MP0005165_increased_susceptibility_to0.70363626
86MP0010234_abnormal_vibrissa_follicle0.68975686
87MP0001851_eye_inflammation0.68844763
88MP0005334_abnormal_fat_pad0.68280798
89MP0003329_amyloid_beta_deposits0.68092211
90MP0003953_abnormal_hormone_level0.66769021
91MP0000343_altered_response_to0.65992673
92MP0005408_hypopigmentation0.63046042
93MP0002896_abnormal_bone_mineralization0.60785147
94MP0005330_cardiomyopathy0.60080360
95MP0000249_abnormal_blood_vessel0.60035677
96MP0008469_abnormal_protein_level0.59897766
97MP0002332_abnormal_exercise_endurance0.58352535
98MP0004782_abnormal_surfactant_physiolog0.58171803
99MP0006035_abnormal_mitochondrial_morpho0.57098412
100MP0004185_abnormal_adipocyte_glucose0.57050436
101MP0003724_increased_susceptibility_to0.55912366
102MP0004484_altered_response_of0.54895487
103MP0000747_muscle_weakness0.54409934
104MP0003705_abnormal_hypodermis_morpholog0.54244147
105MP0009115_abnormal_fat_cell0.53141746
106MP0003566_abnormal_cell_adhesion0.52950684
107MP0005385_cardiovascular_system_phenoty0.52723503
108MP0001544_abnormal_cardiovascular_syste0.52723503
109MP0008438_abnormal_cutaneous_collagen0.52697092
110MP0005266_abnormal_metabolism0.52282887
111MP0003172_abnormal_lysosome_physiology0.51098149
112MP0003868_abnormal_feces_composition0.51051131
113MP0005376_homeostasis/metabolism_phenot0.50878154
114MP0005220_abnormal_exocrine_pancreas0.50767752
115MP0005395_other_phenotype0.50083809
116MP0002089_abnormal_postnatal_growth/wei0.49962743
117MP0003948_abnormal_gas_homeostasis0.49182143
118MP0001879_abnormal_lymphatic_vessel0.48531312
119MP0001663_abnormal_digestive_system0.48385549
120MP0000604_amyloidosis0.47294581
121MP0000470_abnormal_stomach_morphology0.46605521
122MP0002972_abnormal_cardiac_muscle0.46552019
123MP0003075_altered_response_to0.46491694
124MP0002069_abnormal_eating/drinking_beha0.45660279
125MP0001485_abnormal_pinna_reflex0.45264944
126MP0002160_abnormal_reproductive_system0.44863544
127MP0000920_abnormal_myelination0.44751634
128MP0002970_abnormal_white_adipose0.43073379
129MP0005452_abnormal_adipose_tissue0.42417984
130MP0003646_muscle_fatigue0.41988951
131MP0004858_abnormal_nervous_system0.41962695
132MP0003221_abnormal_cardiomyocyte_apopto0.41506751
133MP0010386_abnormal_urinary_bladder0.41350592
134MP0003631_nervous_system_phenotype0.40637047
135MP0001873_stomach_inflammation0.38869043
136MP0009672_abnormal_birth_weight0.38019573
137MP0008872_abnormal_physiological_respon0.37372229
138MP0004742_abnormal_vestibular_system0.37279833
139MP0002938_white_spotting0.37275440
140MP0005501_abnormal_skin_physiology0.36905027

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)7.88240787
2Deep venous thrombosis (HP:0002625)7.83391860
3Hyperlipoproteinemia (HP:0010980)7.64108034
4Gout (HP:0001997)6.57293587
5Increased circulating renin level (HP:0000848)6.18869264
6Abnormality of complement system (HP:0005339)6.06643451
7Hypokalemic alkalosis (HP:0001949)5.97437264
8Metabolic alkalosis (HP:0200114)5.77728841
9Prolonged partial thromboplastin time (HP:0003645)5.59455666
10Hyperglycinuria (HP:0003108)5.48057494
11Hyperactive renin-angiotensin system (HP:0000841)5.32802296
12Hypomagnesemia (HP:0002917)5.30695667
13Polyuria (HP:0000103)5.18392917
14Hypobetalipoproteinemia (HP:0003563)5.16878794
15Proximal tubulopathy (HP:0000114)5.15265416
16Abnormality of chloride homeostasis (HP:0011422)5.12095940
17Abnormal urine output (HP:0012590)5.01916097
18Epidermoid cyst (HP:0200040)4.97894791
19Abnormality of renal excretion (HP:0011036)4.90268120
20Systemic lupus erythematosus (HP:0002725)4.80694457
21Hyperuricemia (HP:0002149)4.79215292
22Increased purine levels (HP:0004368)4.79215292
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.74097616
24Abnormality of serine family amino acid metabolism (HP:0010894)4.68810659
25Abnormality of glycine metabolism (HP:0010895)4.68810659
26Abnormality of glutamine family amino acid metabolism (HP:0010902)4.63926493
27Abnormality of purine metabolism (HP:0004352)4.63907796
28Hypercholesterolemia (HP:0003124)4.55265326
29Ketoacidosis (HP:0001993)4.52161579
30Glomerulonephritis (HP:0000099)4.42534512
31Abnormality of magnesium homeostasis (HP:0004921)4.42506140
32Spontaneous abortion (HP:0005268)4.38741307
33Conjugated hyperbilirubinemia (HP:0002908)4.37384234
34Joint hemorrhage (HP:0005261)4.36330395
35Ketosis (HP:0001946)4.29518368
36Generalized aminoaciduria (HP:0002909)4.15045519
37Alkalosis (HP:0001948)4.14646145
38Abnormal drinking behavior (HP:0030082)4.03102574
39Polydipsia (HP:0001959)4.03102574
40Abnormality of the common coagulation pathway (HP:0010990)3.95631498
41Renal salt wasting (HP:0000127)3.90233868
42Hemorrhage of the eye (HP:0011885)3.76726507
43Abnormality of renin-angiotensin system (HP:0000847)3.76233813
44Glycosuria (HP:0003076)3.74456832
45Abnormality of urine glucose concentration (HP:0011016)3.74456832
46Hyperglycinemia (HP:0002154)3.68674760
47Recurrent gram-negative bacterial infections (HP:0005420)3.66478467
48Hyperaldosteronism (HP:0000859)3.65416934
49Tetany (HP:0001281)3.53376973
50Abnormality of nucleobase metabolism (HP:0010932)3.48680223
51Abnormality of fatty-acid metabolism (HP:0004359)3.44836538
52Hyperammonemia (HP:0001987)3.44138676
53Myocardial infarction (HP:0001658)3.41383697
54Hypolipoproteinemia (HP:0010981)3.40386403
55Skin nodule (HP:0200036)3.39291977
56Abnormality of aromatic amino acid family metabolism (HP:0004338)3.35889852
57Rhabdomyolysis (HP:0003201)3.32508030
58Hypercalciuria (HP:0002150)3.23862995
59Renal tubular acidosis (HP:0001947)3.17501321
60Abnormality of aspartate family amino acid metabolism (HP:0010899)3.16482137
61Increased serum pyruvate (HP:0003542)3.13606577
62Hyperphosphaturia (HP:0003109)3.12814877
63Hydroxyprolinuria (HP:0003080)3.10138486
64Abnormality of proline metabolism (HP:0010907)3.10138486
65Vascular calcification (HP:0004934)3.06194699
66Nephritis (HP:0000123)3.05041317
67Delayed CNS myelination (HP:0002188)3.03905967
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.95832446
69Dicarboxylic aciduria (HP:0003215)2.95832446
70Abnormal urine phosphate concentration (HP:0012599)2.93171012
71Xanthomatosis (HP:0000991)2.89443507
72Small epiphyses (HP:0010585)2.83217205
73Hypoalphalipoproteinemia (HP:0003233)2.82325059
74Abnormality of glycolysis (HP:0004366)2.80972601
75Hypokalemia (HP:0002900)2.80610617
76Myoglobinuria (HP:0002913)2.77853819
77Intrahepatic cholestasis (HP:0001406)2.76255392
78Metabolic acidosis (HP:0001942)2.75137543
79Cardiovascular calcification (HP:0011915)2.74404149
80Nephrolithiasis (HP:0000787)2.69421015
81Lethargy (HP:0001254)2.64033939
82Hypertriglyceridemia (HP:0002155)2.62727274
83Rickets (HP:0002748)2.61864408
84Vomiting (HP:0002013)2.61553617
85Confusion (HP:0001289)2.59622332
86Delayed epiphyseal ossification (HP:0002663)2.56464627
87Vacuolated lymphocytes (HP:0001922)2.53958616
88Abnormality of sulfur amino acid metabolism (HP:0004339)2.52093097
89Hypophosphatemia (HP:0002148)2.51791775
90Fat malabsorption (HP:0002630)2.50243017
91Abnormality of the intrinsic pathway (HP:0010989)2.48569426
92Abnormality of potassium homeostasis (HP:0011042)2.47011367
93Abnormality of methionine metabolism (HP:0010901)2.46517701
94Nephrocalcinosis (HP:0000121)2.45429334
95Malnutrition (HP:0004395)2.44042124
96Hypoglycemic seizures (HP:0002173)2.39253450
97Abnormality of carpal bone ossification (HP:0006257)2.37218875
98Enlarged kidneys (HP:0000105)2.33982620
99Abnormality of pyrimidine metabolism (HP:0004353)2.33679962
100Hypoglycemic coma (HP:0001325)2.29297098
101Methylmalonic aciduria (HP:0012120)2.28397493
102Abnormal enzyme/coenzyme activity (HP:0012379)2.27967802
103Mitral stenosis (HP:0001718)2.27614997
104Dehydration (HP:0001944)2.25325798
105Abnormality of serum amino acid levels (HP:0003112)2.24938989
106Widely patent fontanelles and sutures (HP:0004492)2.24483498
107Hepatocellular carcinoma (HP:0001402)2.23186091
108Abnormal tarsal ossification (HP:0008369)2.20797013
109Sensorimotor neuropathy (HP:0007141)2.20107388
110Metaphyseal cupping (HP:0003021)2.19855370
111Flat acetabular roof (HP:0003180)2.16676062
112Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15437317
113Abnormality of alkaline phosphatase activity (HP:0004379)2.14254147
114Abnormality of renal resorption (HP:0011038)2.12783853
115Hypophosphatemic rickets (HP:0004912)2.11448870
116Abnormality of the vitamin B12 metabolism (HP:0004341)2.10518251
117Abnormal cartilage morphology (HP:0002763)2.08960185
118Renal tubular dysfunction (HP:0000124)2.06812908
119Tubulointerstitial fibrosis (HP:0005576)2.04795066
120Abnormal delivery (HP:0001787)2.04631544
121Irritability (HP:0000737)2.03665663
122Nausea (HP:0002018)2.01449610
123Purpura (HP:0000979)2.00629513
124Thrombophlebitis (HP:0004418)2.00399781
125Oligomenorrhea (HP:0000876)1.99616139
126Abnormality of vitamin B metabolism (HP:0004340)1.98660148
127Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.97426475
128Gingival bleeding (HP:0000225)1.95340864
129Pigmentary retinal degeneration (HP:0001146)1.94759560
130Visceral angiomatosis (HP:0100761)1.94005298
131Pancreatic islet-cell hyperplasia (HP:0004510)1.91884269
132Megaloblastic anemia (HP:0001889)1.90910138
133Hemangiomatosis (HP:0007461)1.89482824
134Neonatal onset (HP:0003623)1.89466182
135Facial shape deformation (HP:0011334)1.88351020
136Potter facies (HP:0002009)1.88351020
137Spastic diplegia (HP:0001264)1.88303619
138Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87187855
139Abnormality of alanine metabolism (HP:0010916)1.87187855
140Hyperalaninemia (HP:0003348)1.87187855
141Reduced antithrombin III activity (HP:0001976)1.86666269
142Esophageal varix (HP:0002040)1.85903036
143Lymphangioma (HP:0100764)1.83329885
144Subcapsular cataract (HP:0000523)1.83099693
145Hyponatremia (HP:0002902)1.81440161
146Bilateral sensorineural hearing impairment (HP:0008619)1.81337867
147Axonal loss (HP:0003447)1.80862342
148Late onset (HP:0003584)1.80478589
149Abnormality of sodium homeostasis (HP:0010931)1.80280921
150Tachypnea (HP:0002789)1.79923674
151Pancreatitis (HP:0001733)1.79278156
152Elevated alkaline phosphatase (HP:0003155)1.78935711
153Abnormal hand bone ossification (HP:0010660)1.78578588
154Abnormality of vitamin metabolism (HP:0100508)1.78561972
155Acanthosis nigricans (HP:0000956)1.77812973
156Glomerulosclerosis (HP:0000096)1.77509050
157Back pain (HP:0003418)1.77355374
158Cupped ribs (HP:0000887)1.76434316
159Abnormality of the periventricular white matter (HP:0002518)1.73646075
160Abnormal pupillary function (HP:0007686)1.73030344
161Cerebral palsy (HP:0100021)1.71507769
162Prenatal maternal abnormality (HP:0002686)1.68374063
163Steatorrhea (HP:0002570)1.67920697
164Cholelithiasis (HP:0001081)1.65271944
165Abnormal ossification of hand bones (HP:0005921)1.64554380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.02060704
2OXSR16.29237457
3WNK35.95777482
4BCKDK5.01355166
5STK394.45765387
6FGFR32.78602290
7MST1R2.50220650
8AKT32.46828599
9PDK32.45978599
10PDK42.45978599
11EPHA32.42130114
12NLK2.40428885
13STK38L2.29864598
14PIK3CA2.29254232
15BMPR1B2.21478890
16MST42.08239038
17PBK1.85341146
18PDGFRA1.83585768
19WNK11.80636235
20SGK2231.78995162
21SGK4941.78995162
22DDR21.76793755
23JAK11.71826453
24PDK21.66875585
25NEK11.61931367
26MAPKAPK31.59391394
27NTRK31.54331741
28ERBB41.48007556
29ICK1.41269200
30TRIM281.32182512
31FGFR11.31967102
32FGFR41.26721602
33SIK31.24978070
34RET1.22449195
35TRIB31.19861836
36PIM21.16982209
37SIK11.14793457
38STK381.14257557
39TYK21.13117264
40LRRK21.08238521
41EIF2AK31.06995671
42ERN11.06900936
43MET1.05877167
44MAPKAPK51.02252351
45MAP3K51.01918803
46PIM11.01120739
47ACVR1B0.98670498
48CAMK1G0.97274428
49OBSCN0.95372973
50BMPR20.93601518
51FLT30.93352690
52SGK30.92063467
53LATS10.90859524
54TYRO30.86420870
55EPHB10.86355744
56SGK20.85395060
57GSK3A0.84693419
58INSRR0.83868748
59PRKAA20.83603731
60PINK10.82152718
61PDGFRB0.80712340
62MAP3K30.80542063
63CDC42BPA0.76167566
64CDK40.75140569
65FRK0.74937560
66GRK60.72856544
67CAMK1D0.72640768
68PDPK10.71776820
69ABL20.67976209
70PRKAA10.65215900
71SRPK10.63342306
72PIK3CG0.63208250
73CAMK10.62580591
74ERBB20.61537203
75MYLK0.61259847
76CDK90.61040792
77PTK60.60597130
78ERBB30.59563306
79MAPK110.58817096
80MAP3K70.58609743
81PTK20.54840785
82SGK10.51332577
83MTOR0.49724788
84PAK30.47512866
85FER0.47440030
86PAK20.46720692
87TIE10.46653489
88PDK10.46558355
89MAPK30.46546716
90CAMKK20.44626487
91GRK70.42050712
92RIPK10.41623703
93MAP2K40.40334650
94NEK60.40073749
95DYRK1B0.38472932
96PRKG10.37600194
97MAP3K20.37410173
98PRKCZ0.37308321
99TGFBR20.37215973
100LMTK20.37106086
101GRK10.35892507
102NTRK10.35304556
103IRAK20.35163225
104MAP2K30.34888897
105STK100.34581476
106RPS6KA30.34538054
107MAP2K10.33664529
108PRKACB0.32777645
109TTK0.31876425
110PRKACG0.31828732
111BMX0.30029208
112CSNK1G20.29907156
113MELK0.28632951
114FGFR20.28574395
115PRKCI0.28487493
116STK30.28193325
117EPHA40.27527239
118BCR0.27226141
119PTK2B0.27223414
120ROCK10.26728630
121RPS6KB10.26720039
122JAK20.26230407
123PNCK0.23980021
124CSNK1G10.23827967
125NEK90.21625559
126MAPK120.20894782
127MAP2K20.20817296
128PKN20.20240464
129AKT20.19492128
130KSR20.19227308
131NME20.19048214
132MAPK150.18776409
133MINK10.18733603
134PRKCD0.18654639
135PRKACA0.18090355
136PRKCA0.18081821
137EPHB20.17767956
138IGF1R0.16460947
139STK110.15928074
140LATS20.15310671
141PRKCQ0.15262208
142CSK0.15161945
143PRKD20.13741302
144SRC0.13521427
145PAK40.13017805
146ROCK20.12123385
147MAPK40.11659518
148INSR0.11074211
149PRKCH0.10298554
150CDK60.09621082
151FYN0.09613325

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.46648985
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.26287731
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.25768717
4Propanoate metabolism_Homo sapiens_hsa006403.22391512
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.06318113
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.04420697
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.74405698
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.70624807
9Fatty acid degradation_Homo sapiens_hsa000712.69704506
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.49033130
11Peroxisome_Homo sapiens_hsa041462.43843882
12Pyruvate metabolism_Homo sapiens_hsa006202.41010645
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.32027835
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.24741583
15Fatty acid metabolism_Homo sapiens_hsa012122.21609296
16Tryptophan metabolism_Homo sapiens_hsa003802.21233295
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.16642078
18Nitrogen metabolism_Homo sapiens_hsa009102.05341746
19beta-Alanine metabolism_Homo sapiens_hsa004102.02468884
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.00967781
21Primary bile acid biosynthesis_Homo sapiens_hsa001202.00249795
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99723273
23Collecting duct acid secretion_Homo sapiens_hsa049661.94342488
24Vitamin digestion and absorption_Homo sapiens_hsa049771.92896873
25Sulfur metabolism_Homo sapiens_hsa009201.86377845
26PPAR signaling pathway_Homo sapiens_hsa033201.82550005
27Carbon metabolism_Homo sapiens_hsa012001.64067114
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63768575
29Arginine biosynthesis_Homo sapiens_hsa002201.60023215
30Bile secretion_Homo sapiens_hsa049761.57880738
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54946374
32Glutathione metabolism_Homo sapiens_hsa004801.52526982
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37282867
34Histidine metabolism_Homo sapiens_hsa003401.36083935
35Arginine and proline metabolism_Homo sapiens_hsa003301.23621432
36Fatty acid elongation_Homo sapiens_hsa000621.23502088
37Chemical carcinogenesis_Homo sapiens_hsa052041.23008599
38Phenylalanine metabolism_Homo sapiens_hsa003601.22583858
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20867630
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18639333
41Starch and sucrose metabolism_Homo sapiens_hsa005001.12529556
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05369508
43Lysine degradation_Homo sapiens_hsa003101.00353054
44* Glycerolipid metabolism_Homo sapiens_hsa005610.98797414
45Biosynthesis of amino acids_Homo sapiens_hsa012300.97035415
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.96661455
47Retinol metabolism_Homo sapiens_hsa008300.92905691
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90614639
49Selenocompound metabolism_Homo sapiens_hsa004500.90426962
50Mineral absorption_Homo sapiens_hsa049780.85225324
51Folate biosynthesis_Homo sapiens_hsa007900.84831993
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.83077208
53Fat digestion and absorption_Homo sapiens_hsa049750.77326407
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.76076769
55Tyrosine metabolism_Homo sapiens_hsa003500.75940655
56Other glycan degradation_Homo sapiens_hsa005110.75234848
57Steroid biosynthesis_Homo sapiens_hsa001000.74267280
58Pentose phosphate pathway_Homo sapiens_hsa000300.72607791
59Protein digestion and absorption_Homo sapiens_hsa049740.70167066
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69580112
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67870449
62Gastric acid secretion_Homo sapiens_hsa049710.67312382
63Prion diseases_Homo sapiens_hsa050200.67293784
64One carbon pool by folate_Homo sapiens_hsa006700.66601919
65Oxidative phosphorylation_Homo sapiens_hsa001900.64029303
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60766384
67Fructose and mannose metabolism_Homo sapiens_hsa000510.60130684
68Metabolic pathways_Homo sapiens_hsa011000.54050009
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53931299
70ABC transporters_Homo sapiens_hsa020100.52737858
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.52278889
72Complement and coagulation cascades_Homo sapiens_hsa046100.47296423
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47007963
74Thyroid hormone synthesis_Homo sapiens_hsa049180.44145660
75Fatty acid biosynthesis_Homo sapiens_hsa000610.41148236
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40026107
77Ovarian steroidogenesis_Homo sapiens_hsa049130.39568679
78Sulfur relay system_Homo sapiens_hsa041220.38424228
79Lysosome_Homo sapiens_hsa041420.37769709
80Pertussis_Homo sapiens_hsa051330.36288903
81Renin-angiotensin system_Homo sapiens_hsa046140.36171986
82Arachidonic acid metabolism_Homo sapiens_hsa005900.35967024
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35391717
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34915148
85Caffeine metabolism_Homo sapiens_hsa002320.33068996
86Insulin signaling pathway_Homo sapiens_hsa049100.29310496
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.26876578
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.22649855
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20655291
90Parkinsons disease_Homo sapiens_hsa050120.20552307
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18246791
92AMPK signaling pathway_Homo sapiens_hsa041520.16269978
93Insulin resistance_Homo sapiens_hsa049310.15727735
94Linoleic acid metabolism_Homo sapiens_hsa005910.14239396
95African trypanosomiasis_Homo sapiens_hsa051430.13668933
96Vitamin B6 metabolism_Homo sapiens_hsa007500.11890407
97Staphylococcus aureus infection_Homo sapiens_hsa051500.11604408
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.10518922
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08542140
100Glucagon signaling pathway_Homo sapiens_hsa049220.05032236
101HIF-1 signaling pathway_Homo sapiens_hsa040660.04789756
102Galactose metabolism_Homo sapiens_hsa000520.04317170
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.04106390
104Alzheimers disease_Homo sapiens_hsa050100.03111315
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.01745914
106Ether lipid metabolism_Homo sapiens_hsa005650.01422450
107Cardiac muscle contraction_Homo sapiens_hsa042600.00239213
108TNF signaling pathway_Homo sapiens_hsa04668-0.1717793
109Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1286539
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1268454
111N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1165268
112Malaria_Homo sapiens_hsa05144-0.0640188
113Amoebiasis_Homo sapiens_hsa05146-0.0382442
114Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0191558
115ECM-receptor interaction_Homo sapiens_hsa04512-0.0150800
116Pancreatic secretion_Homo sapiens_hsa04972-0.0125974
117FoxO signaling pathway_Homo sapiens_hsa04068-0.0063616
118Vibrio cholerae infection_Homo sapiens_hsa05110-0.0040828

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