MOGAT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* intestinal absorption (GO:0050892)9.75506513
2angiotensin maturation (GO:0002003)9.71501678
3epoxygenase P450 pathway (GO:0019373)7.90255582
4vitamin A metabolic process (GO:0006776)6.92561352
5regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.51368303
6fat-soluble vitamin biosynthetic process (GO:0042362)6.39629733
7regulation of guanylate cyclase activity (GO:0031282)6.25264791
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.85564520
9drug metabolic process (GO:0017144)5.66251980
10positive regulation of triglyceride lipase activity (GO:0061365)5.63794875
11positive regulation of lipoprotein lipase activity (GO:0051006)5.63794875
12phospholipid efflux (GO:0033700)5.42234854
13fructose metabolic process (GO:0006000)5.33422721
14plasma lipoprotein particle assembly (GO:0034377)5.31568486
15exogenous drug catabolic process (GO:0042738)5.28080607
16urea metabolic process (GO:0019627)5.28053559
17virion attachment to host cell (GO:0019062)5.27675776
18adhesion of symbiont to host cell (GO:0044650)5.27675776
19actin filament depolymerization (GO:0030042)5.25094231
20regulation of triglyceride catabolic process (GO:0010896)5.23538693
21cellular glucuronidation (GO:0052695)5.19692845
22regulation of cholesterol esterification (GO:0010872)5.18426621
23urea cycle (GO:0000050)5.15719592
24glucuronate metabolic process (GO:0019585)5.07035919
25uronic acid metabolic process (GO:0006063)5.07035919
26protein-lipid complex assembly (GO:0065005)4.99371851
27modified amino acid transport (GO:0072337)4.96984544
28nitrogen cycle metabolic process (GO:0071941)4.84338107
29bile acid and bile salt transport (GO:0015721)4.78701771
30lipoprotein metabolic process (GO:0042157)4.76924885
31ethanol oxidation (GO:0006069)4.73052519
32drug catabolic process (GO:0042737)4.66553822
33positive regulation of guanylate cyclase activity (GO:0031284)4.63058052
34peptide catabolic process (GO:0043171)4.59860633
35purine nucleotide salvage (GO:0032261)4.55339865
36adhesion of symbiont to host (GO:0044406)4.53342642
37flavonoid metabolic process (GO:0009812)4.50043277
38glucose 6-phosphate metabolic process (GO:0051156)4.37003330
39renal system process involved in regulation of blood volume (GO:0001977)4.34392172
40regulation of systemic arterial blood pressure (GO:0003073)4.33537290
41omega-hydroxylase P450 pathway (GO:0097267)4.32937847
42cholesterol efflux (GO:0033344)4.30599184
43regulation of cellular extravasation (GO:0002691)4.11276996
44very-low-density lipoprotein particle assembly (GO:0034379)4.09244556
45reverse cholesterol transport (GO:0043691)4.05964105
46alkaloid metabolic process (GO:0009820)4.05036862
47bile acid metabolic process (GO:0008206)4.04617154
48purine nucleobase biosynthetic process (GO:0009113)4.03861577
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.91441524
50hormone catabolic process (GO:0042447)3.89354058
51arginine metabolic process (GO:0006525)3.83052990
52receptor guanylyl cyclase signaling pathway (GO:0007168)3.82885670
53regulation of cGMP biosynthetic process (GO:0030826)3.79769979
54cholesterol homeostasis (GO:0042632)3.78058222
55maintenance of gastrointestinal epithelium (GO:0030277)3.73963702
56ethanol metabolic process (GO:0006067)3.73880471
57sterol homeostasis (GO:0055092)3.73841182
58* digestive system process (GO:0022600)3.73813781
59response to hepatocyte growth factor (GO:0035728)3.72845755
60cellular response to hepatocyte growth factor stimulus (GO:0035729)3.72845755
61positive regulation of fatty acid biosynthetic process (GO:0045723)3.67937811
62renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.66274968
63hydrogen peroxide catabolic process (GO:0042744)3.64211762
64nucleobase biosynthetic process (GO:0046112)3.63125913
65negative regulation of cholesterol transport (GO:0032375)3.62284326
66negative regulation of sterol transport (GO:0032372)3.62284326
67lipoprotein transport (GO:0042953)3.60674936
68glutamine family amino acid biosynthetic process (GO:0009084)3.55815706
69high-density lipoprotein particle remodeling (GO:0034375)3.53556140
70vitamin transmembrane transport (GO:0035461)3.53251231
71defense response to fungus (GO:0050832)3.53138546
72sterol transport (GO:0015918)3.50239969
73cholesterol transport (GO:0030301)3.50239969
74glycosphingolipid catabolic process (GO:0046479)3.49749735
75complement activation, classical pathway (GO:0006958)3.48690398
76glycolipid catabolic process (GO:0019377)3.48103265
77regulation of lipoprotein metabolic process (GO:0050746)3.47287294
78regulation of cholesterol homeostasis (GO:2000188)3.45585688
79innate immune response in mucosa (GO:0002227)3.45569472
80plasma lipoprotein particle remodeling (GO:0034369)3.43176087
81protein-lipid complex remodeling (GO:0034368)3.43176087
82macromolecular complex remodeling (GO:0034367)3.43176087
83activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.40708059
84vitamin transport (GO:0051180)3.39337796
85homocysteine metabolic process (GO:0050667)3.39187131
86regulation of vitamin metabolic process (GO:0030656)3.38768270
87purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.37875385
883-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.37875385
89plasma lipoprotein particle organization (GO:0071827)3.36793735
90vitamin biosynthetic process (GO:0009110)3.36187635
91NADH metabolic process (GO:0006734)3.32272440
92protein-lipid complex subunit organization (GO:0071825)3.30665028
93digestion (GO:0007586)3.29373139
94drug transmembrane transport (GO:0006855)3.28166718
95positive regulation of triglyceride metabolic process (GO:0090208)3.27576002
96trophectodermal cell differentiation (GO:0001829)3.25207594
97sulfur compound transport (GO:0072348)3.24068242
98positive regulation of pseudopodium assembly (GO:0031274)3.22159063
99drinking behavior (GO:0042756)3.20533428
100peptide hormone processing (GO:0016486)3.19536933
101low-density lipoprotein particle remodeling (GO:0034374)3.17466387
102proline metabolic process (GO:0006560)3.16312295
103response to hydroperoxide (GO:0033194)3.16250570
104nucleotide salvage (GO:0043173)3.15649574
105disruption of cells of other organism (GO:0044364)3.15146866
106killing of cells of other organism (GO:0031640)3.15146866
107signal transduction involved in regulation of gene expression (GO:0023019)3.15118596
108phenylpropanoid metabolic process (GO:0009698)3.11645694
109regulation of cGMP metabolic process (GO:0030823)3.10690082
110negative regulation of B cell apoptotic process (GO:0002903)3.10574461
111oxaloacetate metabolic process (GO:0006107)3.09916834
112midgut development (GO:0007494)3.08451840
113bundle of His cell to Purkinje myocyte communication (GO:0086069)3.07373304
114complement activation, alternative pathway (GO:0006957)3.06557766
115L-alpha-amino acid transmembrane transport (GO:1902475)3.06467024
116complement activation (GO:0006956)3.04982416
117transcytosis (GO:0045056)3.04901888
118DNA unwinding involved in DNA replication (GO:0006268)3.02495725
119oligosaccharide catabolic process (GO:0009313)3.00997979
120renal absorption (GO:0070293)2.99799588
121regulation of protein activation cascade (GO:2000257)2.99458515
122phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.95880181
123very long-chain fatty acid metabolic process (GO:0000038)2.95271270
124regulation of cholesterol metabolic process (GO:0090181)2.94717357
125UDP-N-acetylglucosamine metabolic process (GO:0006047)2.94108634
126urate metabolic process (GO:0046415)2.93513561
127regulation of complement activation (GO:0030449)2.93239566
128regulation of bile acid biosynthetic process (GO:0070857)2.90383808
129pentose-phosphate shunt (GO:0006098)2.89482802
130drug transport (GO:0015893)2.88705275
131heterochromatin organization (GO:0070828)2.86846130
132NADPH regeneration (GO:0006740)2.86219915
133positive regulation of lipid catabolic process (GO:0050996)2.82891304
134regulation of systemic arterial blood pressure by hormone (GO:0001990)2.81463579
135regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.81463579
136endocrine process (GO:0050886)2.81463579
137mucosal immune response (GO:0002385)2.81062780
138hydrogen peroxide metabolic process (GO:0042743)2.78583162
139antibacterial humoral response (GO:0019731)2.76413471
140glycolytic process (GO:0006096)2.75589985
141sulfate transmembrane transport (GO:1902358)2.74325518
142removal of superoxide radicals (GO:0019430)2.72072099
143cellular response to superoxide (GO:0071451)2.72072099
144cellular response to oxygen radical (GO:0071450)2.72072099
145negative regulation of thymocyte apoptotic process (GO:0070244)2.71136175
146regulation of digestive system process (GO:0044058)2.70403396
147antimicrobial humoral response (GO:0019730)2.68148797
148regulation of sterol transport (GO:0032371)2.66085151
149regulation of cholesterol transport (GO:0032374)2.66085151
150fat-soluble vitamin metabolic process (GO:0006775)2.65813937
151organ or tissue specific immune response (GO:0002251)2.61350957
152thyroid hormone metabolic process (GO:0042403)2.57599503
153sulfate transport (GO:0008272)2.55753221
154intestinal cholesterol absorption (GO:0030299)10.0402018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.19501188
2E2F7_22180533_ChIP-Seq_HELA_Human5.12231264
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.48805917
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.38488863
5* EGR1_23403033_ChIP-Seq_LIVER_Mouse3.06387730
6HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.03897703
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.97105495
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.92659951
9* CDX2_20551321_ChIP-Seq_CACO-2_Human2.88479119
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.69236714
11AR_21909140_ChIP-Seq_LNCAP_Human2.61236520
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61026097
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.48842619
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.43055127
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.28420020
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26184889
17SOX2_27498859_Chip-Seq_STOMACH_Mouse2.11462363
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.09387831
19GATA6_25053715_ChIP-Seq_YYC3_Human2.05881924
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.01239612
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99531484
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.98116902
23SRY_22984422_ChIP-ChIP_TESTIS_Rat1.98038104
24GATA4_25053715_ChIP-Seq_YYC3_Human1.97395343
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89217657
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.89034723
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.88945022
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88907509
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87840191
30GATA1_22025678_ChIP-Seq_K562_Human1.86254139
31TCF3_18692474_ChIP-Seq_MEFs_Mouse1.85960840
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.84722618
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81263952
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80404398
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.79306490
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.78664568
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78132832
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.77147608
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.74105353
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71014912
41FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.67775669
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65982167
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.65199405
44PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.60256644
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.60070552
46CLOCK_20551151_ChIP-Seq_293T_Human1.57251641
47ATF3_27146783_Chip-Seq_COLON_Human1.55326844
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54746227
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.54389220
50XRN2_22483619_ChIP-Seq_HELA_Human1.51503558
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50382260
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46925135
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44566360
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.43356137
55* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.42786233
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41493733
57RACK7_27058665_Chip-Seq_MCF-7_Human1.38203682
58OCT4_18692474_ChIP-Seq_MEFs_Mouse1.37442928
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.34425284
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34294467
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32610424
62SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32533801
63BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.31961444
64LXR_22158963_ChIP-Seq_LIVER_Mouse1.30973841
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29662197
66* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27902902
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.23540928
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21575449
69TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20900060
70SOX2_20726797_ChIP-Seq_SW620_Human1.19859522
71RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18137940
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.17203319
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16624494
74SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13465889
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.12932787
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11695642
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11608926
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10972950
79SA1_27219007_Chip-Seq_Bcells_Human1.10470940
80VDR_21846776_ChIP-Seq_THP-1_Human1.10312506
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10105158
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10033901
83TRIM28_21343339_ChIP-Seq_HEK293_Human1.09468741
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.09214425
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08023846
86* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07843119
87* FOXA1_25552417_ChIP-Seq_VCAP_Human1.07709488
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07220507
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06291377
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.05843422
91NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.05649846
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05406565
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04753545
94JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.04658640
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04220312
96ESR1_21235772_ChIP-Seq_MCF-7_Human1.04140321
97* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03939644
98* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02339012
99EGR1_19374776_ChIP-ChIP_THP-1_Human1.01998934
100MYC_22102868_ChIP-Seq_BL_Human1.01143143
101ZNF263_19887448_ChIP-Seq_K562_Human0.99949679
102GABP_17652178_ChIP-ChIP_JURKAT_Human0.99079985
103P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98995847
104GATA2_19941826_ChIP-Seq_K562_Human0.98934095
105YY1_21170310_ChIP-Seq_MESCs_Mouse0.98887500
106CDX2_22108803_ChIP-Seq_LS180_Human0.98030674
107TTF2_22483619_ChIP-Seq_HELA_Human0.97721992
108DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97548153
109SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97532167
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97514708
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97343542
112IRF8_21731497_ChIP-ChIP_J774_Mouse0.96672372
113ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96432749
114BCL6_27268052_Chip-Seq_Bcells_Human0.96337332
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.95321637
116KLF5_25053715_ChIP-Seq_YYC3_Human0.94891110
117BCOR_27268052_Chip-Seq_Bcells_Human0.94854383
118LXR_22292898_ChIP-Seq_THP-1_Human0.94452305
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93686733
120PHF8_20622854_ChIP-Seq_HELA_Human0.93590095
121GATA1_19941826_ChIP-Seq_K562_Human0.92697214
122TP63_19390658_ChIP-ChIP_HaCaT_Human0.92335477
123STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92046767
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91362293
125CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91300149
126MYC_18940864_ChIP-ChIP_HL60_Human0.91153891
127CEBPB_22108803_ChIP-Seq_LS180_Human0.90501712
128CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.90165388
129* CTCF_27219007_Chip-Seq_Bcells_Human0.89726691
130P68_20966046_ChIP-Seq_HELA_Human0.89102350
131TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88464713
132EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88286313
133MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88221777
134CREB1_26743006_Chip-Seq_LNCaP_Human0.87218366
135RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86992722
136GABP_19822575_ChIP-Seq_HepG2_Human0.86830743
137ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86360458
138POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.85089476
139* HNF4A_19822575_ChIP-Seq_HepG2_Human0.85016773
140KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84366221
141RUNX1_27514584_Chip-Seq_MCF-7_Human0.84016310
142NANOG_20526341_ChIP-Seq_ESCs_Human0.83820283
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83820209
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83264435
145TP53_22127205_ChIP-Seq_IMR90_Human0.83195031
146TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83170787
147GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83128863
148VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82929012
149NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.82823751
150FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81360858
151MYCN_18555785_ChIP-Seq_MESCs_Mouse0.81283726
152GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81230534
153EGR1_19032775_ChIP-ChIP_M12_Human0.80433727
154SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78157963
155CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77941629
156SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77920789
157RXR_22108803_ChIP-Seq_LS180_Human0.77858181
158CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77403206
159GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76818361
160KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76597213
161STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.75102312
162EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.74595569
163PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73833791
164ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73466234
165GATA3_24758297_ChIP-Seq_MCF-7_Human0.73310417

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.14147244
2* MP0001666_abnormal_nutrient_absorption4.34260769
3MP0009840_abnormal_foam_cell4.21164009
4MP0004264_abnormal_extraembryonic_tissu3.70499371
5MP0003183_abnormal_peptide_metabolism3.63271238
6MP0010234_abnormal_vibrissa_follicle2.88432119
7MP0002139_abnormal_hepatobiliary_system2.86754631
8MP0005084_abnormal_gallbladder_morpholo2.48160986
9MP0000537_abnormal_urethra_morphology2.46238714
10MP0010352_gastrointestinal_tract_polyps2.42654328
11MP0000462_abnormal_digestive_system2.42518533
12MP0003868_abnormal_feces_composition2.34643673
13MP0003693_abnormal_embryo_hatching2.34068118
14MP0003252_abnormal_bile_duct2.32760826
15MP0005085_abnormal_gallbladder_physiolo2.20192989
16MP0004019_abnormal_vitamin_homeostasis2.15035337
17* MP0010329_abnormal_lipoprotein_level2.08369068
18MP0005409_darkened_coat_color2.04788759
19MP0004147_increased_porphyrin_level2.01958758
20MP0008875_abnormal_xenobiotic_pharmacok1.98032279
21MP0003705_abnormal_hypodermis_morpholog1.95436893
22MP0005377_hearing/vestibular/ear_phenot1.83016424
23MP0003878_abnormal_ear_physiology1.83016424
24MP0003123_paternal_imprinting1.82872838
25MP0006054_spinal_hemorrhage1.81664707
26MP0004957_abnormal_blastocyst_morpholog1.79760508
27MP0005670_abnormal_white_adipose1.73762458
28MP0003866_abnormal_defecation1.67833344
29MP0003806_abnormal_nucleotide_metabolis1.65592504
30MP0002089_abnormal_postnatal_growth/wei1.59120092
31MP0009053_abnormal_anal_canal1.57904827
32MP0002876_abnormal_thyroid_physiology1.57158341
33MP0002138_abnormal_hepatobiliary_system1.56801155
34MP0000490_abnormal_crypts_of1.56023972
35MP0002254_reproductive_system_inflammat1.53378797
36MP0009379_abnormal_foot_pigmentation1.53195116
37MP0001730_embryonic_growth_arrest1.52021785
38MP0009697_abnormal_copulation1.50160941
39MP0005166_decreased_susceptibility_to1.42010022
40MP0003718_maternal_effect1.41226263
41MP0000477_abnormal_intestine_morphology1.38019743
42MP0004043_abnormal_pH_regulation1.37199271
43MP0005636_abnormal_mineral_homeostasis1.35323709
44MP0001765_abnormal_ion_homeostasis1.29122462
45MP0003119_abnormal_digestive_system1.27889252
46MP0003111_abnormal_nucleus_morphology1.26718528
47MP0003879_abnormal_hair_cell1.23533502
48MP0003191_abnormal_cellular_cholesterol1.23492496
49MP0010030_abnormal_orbit_morphology1.21942454
50MP0005381_digestive/alimentary_phenotyp1.21602670
51MP0004858_abnormal_nervous_system1.18635238
52MP0001663_abnormal_digestive_system1.18265693
53MP0005332_abnormal_amino_acid1.16145060
54MP0004782_abnormal_surfactant_physiolog1.15731601
55MP0000538_abnormal_urinary_bladder1.13643485
56MP0003077_abnormal_cell_cycle1.13232223
57MP0009643_abnormal_urine_homeostasis1.12250388
58MP0010155_abnormal_intestine_physiology1.12069793
59MP0000678_abnormal_parathyroid_gland1.11161508
60MP0001188_hyperpigmentation1.08095977
61MP0003315_abnormal_perineum_morphology1.07326359
62MP0005584_abnormal_enzyme/coenzyme_acti1.03580113
63MP0003195_calcinosis1.02514653
64MP0002796_impaired_skin_barrier1.02447945
65MP0005365_abnormal_bile_salt1.02213996
66MP0003890_abnormal_embryonic-extraembry1.01624226
67MP0001849_ear_inflammation1.00669765
68MP0005266_abnormal_metabolism0.95616890
69MP0005501_abnormal_skin_physiology0.95241657
70MP0001756_abnormal_urination0.93321676
71MP0005380_embryogenesis_phenotype0.91723067
72MP0001672_abnormal_embryogenesis/_devel0.91723067
73MP0001873_stomach_inflammation0.89907403
74MP0002086_abnormal_extraembryonic_tissu0.89167447
75MP0003300_gastrointestinal_ulcer0.87021583
76MP0010307_abnormal_tumor_latency0.86577220
77MP0002098_abnormal_vibrissa_morphology0.86574946
78MP0003984_embryonic_growth_retardation0.85597682
79MP0005023_abnormal_wound_healing0.84136948
80MP0001664_abnormal_digestion0.83798934
81MP0009785_altered_susceptibility_to0.83340146
82MP0002088_abnormal_embryonic_growth/wei0.83130335
83MP0008469_abnormal_protein_level0.80975411
84MP0001845_abnormal_inflammatory_respons0.80546783
85* MP0009642_abnormal_blood_homeostasis0.79650502
86MP0001697_abnormal_embryo_size0.79437166
87MP0008932_abnormal_embryonic_tissue0.78165561
88MP0001501_abnormal_sleep_pattern0.78072944
89MP0004270_analgesia0.76192495
90MP0000604_amyloidosis0.73675803
91MP0001764_abnormal_homeostasis0.72038446
92* MP0000609_abnormal_liver_physiology0.71505373
93MP0005167_abnormal_blood-brain_barrier0.71137265
94MP0003283_abnormal_digestive_organ0.70953290
95MP0000230_abnormal_systemic_arterial0.70578101
96MP0002111_abnormal_tail_morphology0.70375095
97MP0000566_synostosis0.70101798
98MP0000516_abnormal_urinary_system0.69095115
99MP0005367_renal/urinary_system_phenotyp0.69095115
100MP0002085_abnormal_embryonic_tissue0.68962925
101MP0002080_prenatal_lethality0.68958553
102MP0005666_abnormal_adipose_tissue0.68848096
103MP0002166_altered_tumor_susceptibility0.68569589
104MP0000350_abnormal_cell_proliferation0.67598196
105MP0002136_abnormal_kidney_physiology0.67319052
106* MP0005535_abnormal_body_temperature0.66845560
107MP0002822_catalepsy0.65421501
108MP0010094_abnormal_chromosome_stability0.64908265
109MP0000467_abnormal_esophagus_morphology0.64808340
110MP0002084_abnormal_developmental_patter0.64675918
111* MP0002971_abnormal_brown_adipose0.64510918
112MP0008872_abnormal_physiological_respon0.64505324
113MP0009764_decreased_sensitivity_to0.63022103
114MP0000249_abnormal_blood_vessel0.62758564
115MP0003436_decreased_susceptibility_to0.62333830
116MP0005058_abnormal_lysosome_morphology0.62208122
117MP0003385_abnormal_body_wall0.61922944
118MP0005319_abnormal_enzyme/_coenzyme0.61869739
119MP0003566_abnormal_cell_adhesion0.59959407
120MP0009333_abnormal_splenocyte_physiolog0.59957983
121MP0005334_abnormal_fat_pad0.59623101
122* MP0005448_abnormal_energy_balance0.59418463
123MP0000598_abnormal_liver_morphology0.59295741
124MP0003724_increased_susceptibility_to0.59292258
125MP0005025_abnormal_response_to0.59268252
126MP0005451_abnormal_body_composition0.58873075
127MP0003941_abnormal_skin_development0.58190789
128MP0003329_amyloid_beta_deposits0.57096145
129MP0005376_homeostasis/metabolism_phenot0.56854594
130MP0009672_abnormal_birth_weight0.56523685
131MP0003638_abnormal_response/metabolism_0.55490150
132* MP0002118_abnormal_lipid_homeostasis0.52475372
133MP0004197_abnormal_fetal_growth/weight/0.51759283
134MP0003303_peritoneal_inflammation0.51452674
135MP0005083_abnormal_biliary_tract0.51375702
136MP0005076_abnormal_cell_differentiation0.50976236
137* MP0002078_abnormal_glucose_homeostasis0.50802036
138MP0000465_gastrointestinal_hemorrhage0.49174817
139MP0002896_abnormal_bone_mineralization0.48914748
140MP0000858_altered_metastatic_potential0.48893399
141MP0003937_abnormal_limbs/digits/tail_de0.46917842
142MP0001881_abnormal_mammary_gland0.46379841
143* MP0003953_abnormal_hormone_level0.44637439
144MP0001835_abnormal_antigen_presentation0.42900763
145MP0004947_skin_inflammation0.42896796
146MP0001485_abnormal_pinna_reflex0.42832617
147* MP0009115_abnormal_fat_cell0.42372288
148MP0001790_abnormal_immune_system0.42099548
149MP0005387_immune_system_phenotype0.42099548

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)6.64236522
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.60562135
3Ileus (HP:0002595)6.58645865
4Acanthocytosis (HP:0001927)5.90588277
5Systemic lupus erythematosus (HP:0002725)5.45280121
6Malnutrition (HP:0004395)5.28957968
7Autoimmune thrombocytopenia (HP:0001973)5.27093382
8Abnormality of proline metabolism (HP:0010907)4.87419906
9Hydroxyprolinuria (HP:0003080)4.87419906
10Complement deficiency (HP:0004431)4.58151534
11Abnormality of complement system (HP:0005339)4.06329311
12Hyperglycinuria (HP:0003108)4.02134337
13Mesangial abnormality (HP:0001966)3.99634105
14Cupped ribs (HP:0000887)3.85461843
15Poikilocytosis (HP:0004447)3.73963553
16Hypolipoproteinemia (HP:0010981)3.72760483
17Right ventricular cardiomyopathy (HP:0011663)3.60073004
18Glomerulonephritis (HP:0000099)3.45333456
19Megaloblastic anemia (HP:0001889)3.43768630
20Autoimmune hemolytic anemia (HP:0001890)3.39395583
21Pigmentary retinal degeneration (HP:0001146)3.36016780
22Deep venous thrombosis (HP:0002625)3.31633004
23Widely patent fontanelles and sutures (HP:0004492)3.28982354
24Hemorrhage of the eye (HP:0011885)3.27520226
25Abnormality of the vitamin B12 metabolism (HP:0004341)3.17448072
26Reticulocytosis (HP:0001923)3.15299774
27Hyperactive renin-angiotensin system (HP:0000841)3.14046581
28Glycosuria (HP:0003076)3.12031886
29Abnormality of urine glucose concentration (HP:0011016)3.12031886
30Alkalosis (HP:0001948)3.11804201
31Conjugated hyperbilirubinemia (HP:0002908)3.07562150
32Decreased circulating renin level (HP:0003351)3.07468026
33Nausea (HP:0002018)3.07464871
34Fat malabsorption (HP:0002630)3.06192417
35Metabolic alkalosis (HP:0200114)3.02210376
36Confusion (HP:0001289)3.01579210
37Abnormality of reticulocytes (HP:0004312)2.99180704
38Abnormality of vitamin B metabolism (HP:0004340)2.92732805
39Steatorrhea (HP:0002570)2.91301541
40Abnormality of serine family amino acid metabolism (HP:0010894)2.86078543
41Abnormality of glycine metabolism (HP:0010895)2.86078543
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.85362331
43B lymphocytopenia (HP:0010976)2.84629293
44Abnormality of B cell number (HP:0010975)2.84629293
45Wide cranial sutures (HP:0010537)2.84556059
46Intrahepatic cholestasis (HP:0001406)2.81839612
47Increased purine levels (HP:0004368)2.80115043
48Hyperuricemia (HP:0002149)2.80115043
49Hypophosphatemia (HP:0002148)2.75915523
50Nephritis (HP:0000123)2.72528658
51Gastrointestinal dysmotility (HP:0002579)2.72527222
52Reticulocytopenia (HP:0001896)2.70524579
53Xanthomatosis (HP:0000991)2.65220863
54Nephrolithiasis (HP:0000787)2.63953421
55Increased IgE level (HP:0003212)2.63235688
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.63113867
57Epidermoid cyst (HP:0200040)2.62541242
58Proximal tubulopathy (HP:0000114)2.61704030
59Prolonged partial thromboplastin time (HP:0003645)2.60301781
60Abdominal distention (HP:0003270)2.57924403
61Macrocytic anemia (HP:0001972)2.57231925
62Abnormality of pyrimidine metabolism (HP:0004353)2.53134020
63Increased mean platelet volume (HP:0011877)2.52411145
64Abnormality of renin-angiotensin system (HP:0000847)2.51300997
65Congenital sensorineural hearing impairment (HP:0008527)2.50731828
66Hyperphosphaturia (HP:0003109)2.49122931
67Abnormality of aromatic amino acid family metabolism (HP:0004338)2.48523606
68Abnormality of sulfur amino acid metabolism (HP:0004339)2.44543739
69Combined immunodeficiency (HP:0005387)2.44025140
70Hypercholesterolemia (HP:0003124)2.41392456
71Abnormality of monocarboxylic acid metabolism (HP:0010996)2.40861790
72Chronic diarrhea (HP:0002028)2.38273813
73Gout (HP:0001997)2.37881875
74Facial shape deformation (HP:0011334)2.36014027
75Potter facies (HP:0002009)2.36014027
76Focal segmental glomerulosclerosis (HP:0000097)2.34305442
77Severe combined immunodeficiency (HP:0004430)2.33807021
78Abnormality of vitamin metabolism (HP:0100508)2.33686632
79Hypotension (HP:0002615)2.33141766
80Hyperlipoproteinemia (HP:0010980)2.30967356
81Abnormality of nucleobase metabolism (HP:0010932)2.28360757
82Hyperparathyroidism (HP:0000843)2.25070635
83Multiple enchondromatosis (HP:0005701)2.24725115
84Eczematoid dermatitis (HP:0000976)2.22468094
85Colon cancer (HP:0003003)2.20630201
86Abnormal platelet volume (HP:0011876)2.18537605
87Cerebral palsy (HP:0100021)2.18322768
88Rectal prolapse (HP:0002035)2.16962378
89Abnormality of purine metabolism (HP:0004352)2.15974126
90Posterior subcapsular cataract (HP:0007787)2.13236795
91Abnormal urine phosphate concentration (HP:0012599)2.13012707
92Pancreatitis (HP:0001733)2.12687256
93Protuberant abdomen (HP:0001538)2.12421041
94Late onset (HP:0003584)2.09919842
95Abnormality of glycolysis (HP:0004366)2.09258672
96Increased serum pyruvate (HP:0003542)2.09258672
97Microretrognathia (HP:0000308)2.09102951
98Dicarboxylic aciduria (HP:0003215)2.02058109
99Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02058109
100Enlarged epiphyses (HP:0010580)2.00116170
101Renal tubular acidosis (HP:0001947)1.99332478
102Irritability (HP:0000737)1.96930811
103Joint hemorrhage (HP:0005261)1.96847801
104Abnormal biliary tract morphology (HP:0012440)1.96688078
105Hyperammonemia (HP:0001987)1.94164336
106Abnormal glucose tolerance (HP:0001952)1.94091534
107Granulocytopenia (HP:0001913)1.93855907
108Dehydration (HP:0001944)1.93111619
109Aplasia/hypoplasia of the humerus (HP:0006507)1.93064535
110Nonimmune hydrops fetalis (HP:0001790)1.91479654
111Breast hypoplasia (HP:0003187)1.91467785
112Abnormal enzyme/coenzyme activity (HP:0012379)1.90299374
113Metaphyseal cupping (HP:0003021)1.90016353
114Woolly hair (HP:0002224)1.89840449
115Abnormality of alkaline phosphatase activity (HP:0004379)1.88906926
116Rickets (HP:0002748)1.87956663
117Abnormal tarsal ossification (HP:0008369)1.87139740
118Rhabdomyolysis (HP:0003201)1.85087837
119Glomerulosclerosis (HP:0000096)1.85051083
120Skin nodule (HP:0200036)1.84593920
121Short humerus (HP:0005792)1.83646705
122Abnormality of abdominal situs (HP:0011620)1.80993995
123Abdominal situs inversus (HP:0003363)1.80993995
124Subcapsular cataract (HP:0000523)1.80919698
125Abnormal gallbladder physiology (HP:0012438)1.80779855
126Cholecystitis (HP:0001082)1.80779855
127Vascular calcification (HP:0004934)1.80707871
128Palpitations (HP:0001962)1.79446133
129Abnormality of the costochondral junction (HP:0000919)1.79163419
130Eosinophilia (HP:0001880)1.79093646
131Metabolic acidosis (HP:0001942)1.77977109
132Polycythemia (HP:0001901)1.77720359
133Gingivitis (HP:0000230)1.77328779
134Delayed CNS myelination (HP:0002188)1.76794385
135Thyroiditis (HP:0100646)1.76185895
136Pili torti (HP:0003777)1.75510613
137Flat acetabular roof (HP:0003180)1.75218982
138Abnormal albumin level (HP:0012116)1.73380590
139Hypoalbuminemia (HP:0003073)1.73380590
140Hypoglycemic coma (HP:0001325)1.72872014
141Trismus (HP:0000211)1.72193575
142Generalized aminoaciduria (HP:0002909)1.71446730
143Abnormality of the 1st metacarpal (HP:0010009)1.71082907
144Growth hormone excess (HP:0000845)1.70851992
145Biliary tract neoplasm (HP:0100574)1.70407474
146Thin bony cortex (HP:0002753)1.67346242
147Abnormality of the gastric mucosa (HP:0004295)1.64807955
148Abnormality of small intestinal villus morphology (HP:0011472)1.62785717
149Villous atrophy (HP:0011473)1.62785717
150Delayed epiphyseal ossification (HP:0002663)1.61768019

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.71535662
2MST43.69567825
3GRK63.47540499
4TESK23.25101723
5BUB13.17409326
6FGFR43.01095734
7MAP3K102.88973910
8MST1R2.79688566
9LMTK22.72719881
10EPHA22.65284617
11TESK12.55992033
12NME12.43347293
13PRKG22.29106888
14STK102.26550102
15TTK2.10311096
16PAK42.09685979
17MAP3K82.08280683
18MAP3K112.02216895
19MAP2K22.01870532
20PIK3CA2.01492929
21ERN12.01309480
22PTK61.87722887
23TYK21.82228315
24AKT31.79951782
25WEE11.78540629
26CDC71.77784211
27RIPK11.76907598
28EPHA31.76349964
29STK391.71879300
30KDR1.63615135
31EIF2AK11.61039749
32LATS21.59291146
33FGFR31.59194756
34NEK11.48967793
35EPHB11.42882309
36EPHB21.41282939
37MAP3K31.38890263
38PRPF4B1.30843114
39NEK21.29601186
40MAP4K11.28075467
41MET1.27445167
42SCYL21.25676855
43LRRK21.25380819
44MAP3K121.23903897
45MAP2K31.23354423
46OXSR11.22102764
47MAP3K11.21910338
48MAP3K21.17151842
49TAOK11.16690002
50EPHA41.15149989
51RIPK41.14717800
52CDK71.10972061
53PTK21.10379135
54PDPK11.05457483
55AURKB1.05067661
56LIMK11.03760707
57STK241.03526234
58MAP2K61.03515143
59TNIK0.96536460
60CDC42BPA0.95731400
61PRKCI0.93950292
62CDK120.89827881
63BMX0.89819024
64TGFBR10.87544040
65DYRK1B0.87255474
66NLK0.86899198
67NUAK10.85537111
68PASK0.84633409
69PAK10.84248575
70PRKACG0.83134949
71BRSK20.81511945
72TAOK20.80333472
73CDK60.75717219
74PDK10.74925948
75PLK10.74528876
76KSR20.74347356
77ACVR1B0.73142965
78LATS10.71199979
79CDK40.71065556
80TSSK60.69422981
81RET0.66258879
82EIF2AK30.65030719
83PBK0.63860073
84TBK10.60529232
85JAK10.60317168
86PRKCZ0.58792199
87AKT20.58231197
88CHEK20.57493376
89PLK40.56835395
90RPS6KB20.54293416
91ICK0.53839221
92IRAK10.53586359
93FGFR10.52919692
94PRKCA0.52383189
95SMG10.52275948
96SRC0.50980534
97AURKA0.49398144
98MAPK110.49226836
99BCKDK0.49078318
100CSF1R0.48031500
101ALK0.47325617
102BRAF0.47190708
103TLK10.47145940
104JAK20.46865004
105PKN20.46536275
106EEF2K0.45081225
107MAP2K10.44652029
108STK40.44185513
109ABL20.44131092
110CAMK2D0.43172901
111ZAP700.41660366
112ERBB20.40675243
113DDR20.40501366
114FYN0.39997368
115CHEK10.39251603
116MATK0.39197660
117YES10.38864375
118PIM20.38182825
119SRPK10.37978044
120MELK0.37238300
121STK30.36978734
122MYLK0.36730638
123STK38L0.36626969
124SIK10.35180452
125IKBKE0.35142257
126BRSK10.34532779
127CSK0.34487573
128ATR0.32540133
129PIM10.32387237
130IGF1R0.32060349
131ITK0.31050471
132WNK40.30489468
133PRKAA20.30427997
134PAK20.30299093
135PRKCD0.30251751
136PLK30.29863631
137BMPR20.28051713
138TRIB30.28041032
139FER0.27806246
140PDGFRA0.26741235
141CAMK2G0.26734466
142PDK20.26107134
143MAP3K140.25946802
144IRAK30.25878202
145MAPKAPK20.25355767
146VRK10.25254294
147TGFBR20.24674396
148RPS6KA40.24233735
149PDK30.24205723
150SYK0.21840357
151RPS6KA20.20137589
152JAK30.19987591
153CASK0.19254907
154LYN0.18638182
155MAPK70.18525592
156NEK60.17892930
157PRKACA0.17764280

Predicted pathways (KEGG)

RankGene SetZ-score
1* Fat digestion and absorption_Homo sapiens_hsa049755.44923524
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.98471866
3Vitamin digestion and absorption_Homo sapiens_hsa049774.35909949
4Renin-angiotensin system_Homo sapiens_hsa046144.28584348
5Mineral absorption_Homo sapiens_hsa049783.54014373
6Galactose metabolism_Homo sapiens_hsa000523.06291078
7Folate biosynthesis_Homo sapiens_hsa007902.45398626
8Starch and sucrose metabolism_Homo sapiens_hsa005002.41569772
9Caffeine metabolism_Homo sapiens_hsa002322.34664941
10Fructose and mannose metabolism_Homo sapiens_hsa000512.22916621
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.19731439
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.08881844
13Protein digestion and absorption_Homo sapiens_hsa049742.00146247
14Glutathione metabolism_Homo sapiens_hsa004801.99280283
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.87310233
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.84351919
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.74858116
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62340735
19Sulfur metabolism_Homo sapiens_hsa009201.60684367
20Bile secretion_Homo sapiens_hsa049761.52974818
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.49979768
22Histidine metabolism_Homo sapiens_hsa003401.49434812
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48147307
24Carbon metabolism_Homo sapiens_hsa012001.38812325
25Complement and coagulation cascades_Homo sapiens_hsa046101.38661930
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.38321781
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36395448
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.35940110
29Pentose phosphate pathway_Homo sapiens_hsa000301.32069722
30Biosynthesis of amino acids_Homo sapiens_hsa012301.27401954
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21158611
32Pyruvate metabolism_Homo sapiens_hsa006201.20892165
33DNA replication_Homo sapiens_hsa030301.20192212
34Arginine and proline metabolism_Homo sapiens_hsa003301.17368242
35Tyrosine metabolism_Homo sapiens_hsa003501.15195246
36Staphylococcus aureus infection_Homo sapiens_hsa051501.09128325
37PPAR signaling pathway_Homo sapiens_hsa033201.09121032
38Ribosome_Homo sapiens_hsa030101.03865406
39Arginine biosynthesis_Homo sapiens_hsa002201.01489099
40Drug metabolism - other enzymes_Homo sapiens_hsa009830.99439557
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98535853
42Tryptophan metabolism_Homo sapiens_hsa003800.95684205
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94327431
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90964610
45Fatty acid degradation_Homo sapiens_hsa000710.89432681
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87245872
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86800025
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82745429
49Mismatch repair_Homo sapiens_hsa034300.80059860
50One carbon pool by folate_Homo sapiens_hsa006700.76116638
51Asthma_Homo sapiens_hsa053100.74963370
52* Glycerolipid metabolism_Homo sapiens_hsa005610.73973577
53Butanoate metabolism_Homo sapiens_hsa006500.71376308
54Selenocompound metabolism_Homo sapiens_hsa004500.70717658
55Spliceosome_Homo sapiens_hsa030400.70558469
56Sphingolipid metabolism_Homo sapiens_hsa006000.68853480
57Thyroid cancer_Homo sapiens_hsa052160.68222140
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63815908
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.63804603
60Tight junction_Homo sapiens_hsa045300.63292176
61Ether lipid metabolism_Homo sapiens_hsa005650.62869982
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62836645
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59301665
64Pyrimidine metabolism_Homo sapiens_hsa002400.58770576
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57393234
66Thyroid hormone synthesis_Homo sapiens_hsa049180.57122571
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55753037
68beta-Alanine metabolism_Homo sapiens_hsa004100.55324354
69Other glycan degradation_Homo sapiens_hsa005110.54559685
70Nitrogen metabolism_Homo sapiens_hsa009100.54139267
71RNA transport_Homo sapiens_hsa030130.54137490
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.53840922
73Bladder cancer_Homo sapiens_hsa052190.53758336
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53210240
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53086162
76Proteasome_Homo sapiens_hsa030500.53012260
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52403340
78Arachidonic acid metabolism_Homo sapiens_hsa005900.52204538
79Cell cycle_Homo sapiens_hsa041100.52032370
80Allograft rejection_Homo sapiens_hsa053300.50608311
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.50541026
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.50505321
83Pancreatic secretion_Homo sapiens_hsa049720.48254173
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47561247
85Fatty acid biosynthesis_Homo sapiens_hsa000610.46667536
86Autoimmune thyroid disease_Homo sapiens_hsa053200.46013200
87Base excision repair_Homo sapiens_hsa034100.45726196
88Purine metabolism_Homo sapiens_hsa002300.44439190
89Retinol metabolism_Homo sapiens_hsa008300.42427631
90Graft-versus-host disease_Homo sapiens_hsa053320.42226954
91Adherens junction_Homo sapiens_hsa045200.41790102
92ABC transporters_Homo sapiens_hsa020100.40808864
93Insulin resistance_Homo sapiens_hsa049310.40756539
94Chemical carcinogenesis_Homo sapiens_hsa052040.38715255
95Metabolic pathways_Homo sapiens_hsa011000.38365606
96Phenylalanine metabolism_Homo sapiens_hsa003600.36532938
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36048057
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.35729873
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34278031
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.32016811
101Pertussis_Homo sapiens_hsa051330.30107243
102Peroxisome_Homo sapiens_hsa041460.29404361
103Linoleic acid metabolism_Homo sapiens_hsa005910.28822999
104Type I diabetes mellitus_Homo sapiens_hsa049400.28078098
105Lysine degradation_Homo sapiens_hsa003100.27782594
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27138573
107Sulfur relay system_Homo sapiens_hsa041220.27070953
108Prion diseases_Homo sapiens_hsa050200.25494093
109Legionellosis_Homo sapiens_hsa051340.24648167
110RNA polymerase_Homo sapiens_hsa030200.24275778
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23963229
112Glucagon signaling pathway_Homo sapiens_hsa049220.23250153
113Renin secretion_Homo sapiens_hsa049240.21727895
114HIF-1 signaling pathway_Homo sapiens_hsa040660.21629957
115p53 signaling pathway_Homo sapiens_hsa041150.21089102
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20993024
117Hippo signaling pathway_Homo sapiens_hsa043900.20247354
118Fatty acid elongation_Homo sapiens_hsa000620.17070550
119Homologous recombination_Homo sapiens_hsa034400.15206136
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14991592
121Fatty acid metabolism_Homo sapiens_hsa012120.14930692
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.14688903
123Antigen processing and presentation_Homo sapiens_hsa046120.13501132
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.13121682
125Nucleotide excision repair_Homo sapiens_hsa034200.12874516
126Vitamin B6 metabolism_Homo sapiens_hsa007500.11778627
127Steroid biosynthesis_Homo sapiens_hsa001000.11770736
128Propanoate metabolism_Homo sapiens_hsa006400.11285350
129Basal cell carcinoma_Homo sapiens_hsa052170.10327911
130Leishmaniasis_Homo sapiens_hsa051400.10043930
131Salmonella infection_Homo sapiens_hsa051320.08259938
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06884822
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.06829647
134Hepatitis C_Homo sapiens_hsa051600.05615484
135AMPK signaling pathway_Homo sapiens_hsa041520.05550590
136Viral carcinogenesis_Homo sapiens_hsa052030.05400547
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.04890206

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