MOGAT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed 12618427]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.09891600
2water-soluble vitamin biosynthetic process (GO:0042364)4.42413082
3sulfation (GO:0051923)4.29398239
4DNA deamination (GO:0045006)4.25835974
5fucose catabolic process (GO:0019317)4.20717567
6L-fucose metabolic process (GO:0042354)4.20717567
7L-fucose catabolic process (GO:0042355)4.20717567
8tryptophan catabolic process (GO:0006569)4.05349862
9indole-containing compound catabolic process (GO:0042436)4.05349862
10indolalkylamine catabolic process (GO:0046218)4.05349862
11indolalkylamine metabolic process (GO:0006586)3.93153874
12kynurenine metabolic process (GO:0070189)3.69974457
13drug catabolic process (GO:0042737)3.67541586
14kidney morphogenesis (GO:0060993)3.57628218
15purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.52707008
163-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.52707008
17exogenous drug catabolic process (GO:0042738)3.44001822
18tryptophan metabolic process (GO:0006568)3.40335952
19protein polyglutamylation (GO:0018095)3.38304204
20cellular response to ATP (GO:0071318)3.26973816
21regulation of triglyceride catabolic process (GO:0010896)3.17737594
22detection of light stimulus involved in sensory perception (GO:0050962)3.17513844
23detection of light stimulus involved in visual perception (GO:0050908)3.17513844
24gamma-aminobutyric acid transport (GO:0015812)3.16354906
25cellular ketone body metabolic process (GO:0046950)3.16325919
26flavonoid metabolic process (GO:0009812)3.15646438
27positive regulation of fatty acid transport (GO:2000193)3.11047568
28indole-containing compound metabolic process (GO:0042430)3.10839669
29detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.09963866
30rRNA catabolic process (GO:0016075)3.09528198
31response to pheromone (GO:0019236)3.04619448
32negative regulation of telomere maintenance (GO:0032205)3.03472906
33arginine metabolic process (GO:0006525)3.02540367
34primary amino compound metabolic process (GO:1901160)3.02444232
35protein complex biogenesis (GO:0070271)3.00686845
36somite development (GO:0061053)2.95298654
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94720795
38aromatic amino acid family catabolic process (GO:0009074)2.92534252
39mitochondrial respiratory chain complex I assembly (GO:0032981)2.91512241
40NADH dehydrogenase complex assembly (GO:0010257)2.91512241
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91512241
42transepithelial transport (GO:0070633)2.90575725
43amine catabolic process (GO:0009310)2.89953788
44cellular biogenic amine catabolic process (GO:0042402)2.89953788
45positive regulation of fatty acid oxidation (GO:0046321)2.89588228
46oxidative demethylation (GO:0070989)2.89093495
47cytidine deamination (GO:0009972)2.86572922
48cytidine metabolic process (GO:0046087)2.86572922
49cytidine catabolic process (GO:0006216)2.86572922
50axoneme assembly (GO:0035082)2.84465505
51platelet dense granule organization (GO:0060155)2.83931165
52regulation of mesoderm development (GO:2000380)2.82933870
53ketone body metabolic process (GO:1902224)2.82458662
54negative regulation of mast cell activation (GO:0033004)2.81579558
55serotonin metabolic process (GO:0042428)2.78108496
56preassembly of GPI anchor in ER membrane (GO:0016254)2.77362733
57mitochondrial respiratory chain complex assembly (GO:0033108)2.73977857
58vitamin biosynthetic process (GO:0009110)2.71153203
59negative regulation of transcription regulatory region DNA binding (GO:2000678)2.71074046
60regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.70820074
61positive regulation of icosanoid secretion (GO:0032305)2.69590093
62alkaloid metabolic process (GO:0009820)2.66281983
63nephron tubule morphogenesis (GO:0072078)2.65219781
64nephron epithelium morphogenesis (GO:0072088)2.65219781
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.61955860
66mannosylation (GO:0097502)2.61656795
67regulation of action potential (GO:0098900)2.61078505
68piRNA metabolic process (GO:0034587)2.60968989
69benzene-containing compound metabolic process (GO:0042537)2.59961413
70cellular anion homeostasis (GO:0030002)2.57967758
71regulation of hippo signaling (GO:0035330)2.57598999
72GPI anchor metabolic process (GO:0006505)2.54944807
73adaptation of signaling pathway (GO:0023058)2.53976849
74thyroid hormone metabolic process (GO:0042403)2.53452111
75respiratory chain complex IV assembly (GO:0008535)2.53394208
76sulfate transmembrane transport (GO:1902358)2.52224555
77synaptic transmission, cholinergic (GO:0007271)2.51149789
78S-adenosylmethionine metabolic process (GO:0046500)2.50692157
79neuronal action potential (GO:0019228)2.50145133
80reflex (GO:0060004)2.49100151
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.48529740
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.48529740
83arginine catabolic process (GO:0006527)2.47608480
84regulation of rhodopsin mediated signaling pathway (GO:0022400)2.46404993
85drug metabolic process (GO:0017144)2.45671211
86aromatic amino acid family metabolic process (GO:0009072)2.43962442
87regulation of sequestering of triglyceride (GO:0010889)2.43402595
88pyrimidine ribonucleoside catabolic process (GO:0046133)2.42700526
89cytochrome complex assembly (GO:0017004)2.42065583
90rhodopsin mediated signaling pathway (GO:0016056)2.41241154
91NAD biosynthetic process (GO:0009435)2.38248382
92glyoxylate metabolic process (GO:0046487)2.37943461
93cell proliferation in forebrain (GO:0021846)2.37569397
94epithelial cilium movement (GO:0003351)2.37446485
95negative regulation of synaptic transmission, GABAergic (GO:0032229)2.37269014
96cornea development in camera-type eye (GO:0061303)2.36981326
97regulation of memory T cell differentiation (GO:0043380)2.36340661
98positive regulation of oligodendrocyte differentiation (GO:0048714)2.36254244
99regulation of guanylate cyclase activity (GO:0031282)2.34859171
100negative regulation of systemic arterial blood pressure (GO:0003085)2.34294982

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.63143810
2VDR_22108803_ChIP-Seq_LS180_Human3.19260064
3EZH2_22144423_ChIP-Seq_EOC_Human2.87942464
4GBX2_23144817_ChIP-Seq_PC3_Human2.72009948
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.59625290
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30034917
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28423595
8IGF1R_20145208_ChIP-Seq_DFB_Human2.15855192
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05979179
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.02906689
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98557975
12CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93687262
13CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89187419
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89092348
15ER_23166858_ChIP-Seq_MCF-7_Human1.81034734
16EGR1_23403033_ChIP-Seq_LIVER_Mouse1.80274088
17P300_19829295_ChIP-Seq_ESCs_Human1.78079754
18* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77087584
19IRF1_19129219_ChIP-ChIP_H3396_Human1.69479972
20FUS_26573619_Chip-Seq_HEK293_Human1.69438993
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66874484
22BCAT_22108803_ChIP-Seq_LS180_Human1.64506739
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60501186
24EWS_26573619_Chip-Seq_HEK293_Human1.58070942
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52237999
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48775238
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46807632
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46382148
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43178782
30CBP_20019798_ChIP-Seq_JUKART_Human1.40938463
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40938463
32FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40345104
33FOXA1_25329375_ChIP-Seq_VCAP_Human1.40345104
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40009024
35TP53_22573176_ChIP-Seq_HFKS_Human1.39986760
36STAT3_23295773_ChIP-Seq_U87_Human1.38480800
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37695642
38TAF15_26573619_Chip-Seq_HEK293_Human1.37584945
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37547748
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37314856
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36871755
42NCOR_22424771_ChIP-Seq_293T_Human1.36377533
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35200879
44REST_21632747_ChIP-Seq_MESCs_Mouse1.35134802
45TCF4_23295773_ChIP-Seq_U87_Human1.34611291
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.33352669
47NANOG_19829295_ChIP-Seq_ESCs_Human1.33263546
48SOX2_19829295_ChIP-Seq_ESCs_Human1.33263546
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.32393897
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31432686
51SMAD4_21799915_ChIP-Seq_A2780_Human1.30407068
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30165195
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.29750277
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28645170
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28145863
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.27728274
57AR_25329375_ChIP-Seq_VCAP_Human1.25636298
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25519781
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23951775
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.23826163
61AR_20517297_ChIP-Seq_VCAP_Human1.23801603
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23263855
63TCF4_22108803_ChIP-Seq_LS180_Human1.23108416
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.22539717
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21910699
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20771631
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19726922
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.18567280
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15609512
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.14678304
71MYC_18940864_ChIP-ChIP_HL60_Human1.12142836
72HOXB7_26014856_ChIP-Seq_BT474_Human1.11872110
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11312531
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10996097
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10885505
76CDX2_22108803_ChIP-Seq_LS180_Human1.10725719
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.10599919
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10575246
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.10514587
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.09286570
81MYC_19829295_ChIP-Seq_ESCs_Human1.08191115
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08101514
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07845184
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07845184
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07048883
86RNF2_27304074_Chip-Seq_NSC_Mouse1.06159402
87RUNX2_22187159_ChIP-Seq_PCA_Human1.05679019
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05500526
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.05488993
90NANOG_20526341_ChIP-Seq_ESCs_Human1.05381674
91ERA_21632823_ChIP-Seq_H3396_Human1.05303710
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01894952
93TAF2_19829295_ChIP-Seq_ESCs_Human1.01794875
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.00426756
95P53_22387025_ChIP-Seq_ESCs_Mouse1.00161782
96STAT3_18555785_Chip-Seq_ESCs_Mouse0.99879778
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99835347
98EZH2_27294783_Chip-Seq_ESCs_Mouse0.97523112
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97380757
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97125016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.80385270
2MP0003195_calcinosis3.43318488
3MP0003646_muscle_fatigue2.83079690
4MP0002876_abnormal_thyroid_physiology2.79483369
5MP0008875_abnormal_xenobiotic_pharmacok2.71832532
6MP0002139_abnormal_hepatobiliary_system2.46626079
7MP0005085_abnormal_gallbladder_physiolo2.45449963
8MP0008872_abnormal_physiological_respon2.44391973
9MP0005646_abnormal_pituitary_gland2.43336396
10MP0005551_abnormal_eye_electrophysiolog2.35795158
11MP0002138_abnormal_hepatobiliary_system2.17473266
12MP0002837_dystrophic_cardiac_calcinosis2.07883763
13MP0005365_abnormal_bile_salt2.06662830
14MP0004147_increased_porphyrin_level2.04720155
15MP0002102_abnormal_ear_morphology2.04371551
16MP0006292_abnormal_olfactory_placode2.02401506
17MP0008877_abnormal_DNA_methylation1.96698715
18MP0004885_abnormal_endolymph1.89949566
19MP0001485_abnormal_pinna_reflex1.89779695
20MP0001968_abnormal_touch/_nociception1.77995542
21MP0010329_abnormal_lipoprotein_level1.73197250
22MP0003011_delayed_dark_adaptation1.71166289
23MP0006072_abnormal_retinal_apoptosis1.68421183
24MP0004043_abnormal_pH_regulation1.61151872
25MP0003252_abnormal_bile_duct1.59432113
26MP0005645_abnormal_hypothalamus_physiol1.57776092
27MP0005332_abnormal_amino_acid1.53972734
28MP0004145_abnormal_muscle_electrophysio1.50336529
29MP0002638_abnormal_pupillary_reflex1.48430262
30MP0001501_abnormal_sleep_pattern1.48301243
31MP0004142_abnormal_muscle_tone1.48060982
32MP0002736_abnormal_nociception_after1.45608455
33MP0009745_abnormal_behavioral_response1.44920003
34MP0002272_abnormal_nervous_system1.43340607
35MP0005253_abnormal_eye_physiology1.40702099
36MP0005670_abnormal_white_adipose1.40000138
37MP0000372_irregular_coat_pigmentation1.39491055
38MP0009046_muscle_twitch1.39296732
39MP0000631_abnormal_neuroendocrine_gland1.38698836
40MP0004019_abnormal_vitamin_homeostasis1.36395039
41MP0003787_abnormal_imprinting1.36243952
42MP0002938_white_spotting1.36123887
43MP0001666_abnormal_nutrient_absorption1.33571417
44MP0004133_heterotaxia1.28448695
45MP0001986_abnormal_taste_sensitivity1.24750266
46MP0000427_abnormal_hair_cycle1.17644519
47MP0005167_abnormal_blood-brain_barrier1.17369428
48MP0000230_abnormal_systemic_arterial1.14769646
49MP0002160_abnormal_reproductive_system1.14463847
50MP0005389_reproductive_system_phenotype1.13524238
51MP0005084_abnormal_gallbladder_morpholo1.12946413
52MP0000383_abnormal_hair_follicle1.11993929
53MP0005379_endocrine/exocrine_gland_phen1.11535719
54MP0001764_abnormal_homeostasis1.10432911
55MP0002733_abnormal_thermal_nociception1.08459168
56MP0010386_abnormal_urinary_bladder1.06823544
57MP0004742_abnormal_vestibular_system1.06697813
58MP0002163_abnormal_gland_morphology1.06568648
59MP0008775_abnormal_heart_ventricle1.04731313
60MP0002735_abnormal_chemical_nociception1.04437994
61MP0003122_maternal_imprinting1.04374299
62MP0003283_abnormal_digestive_organ1.04019109
63MP0005410_abnormal_fertilization1.02440411
64MP0001486_abnormal_startle_reflex1.01929474
65MP0003638_abnormal_response/metabolism_1.01639939
66MP0001970_abnormal_pain_threshold1.01397781
67MP0005636_abnormal_mineral_homeostasis0.99677149
68MP0002557_abnormal_social/conspecific_i0.99544914
69MP0002064_seizures0.98312155
70MP0009697_abnormal_copulation0.96687521
71MP0003879_abnormal_hair_cell0.95180285
72MP0002653_abnormal_ependyma_morphology0.95123297
73MP0003878_abnormal_ear_physiology0.94240492
74MP0005377_hearing/vestibular/ear_phenot0.94240492
75MP0001765_abnormal_ion_homeostasis0.93103495
76MP0001664_abnormal_digestion0.91855224
77MP0000569_abnormal_digit_pigmentation0.91666649
78MP0003136_yellow_coat_color0.90663538
79MP0005195_abnormal_posterior_eye0.89273138
80MP0001963_abnormal_hearing_physiology0.88053413
81MP0002572_abnormal_emotion/affect_behav0.87214147
82MP0004130_abnormal_muscle_cell0.87090702
83MP0005671_abnormal_response_to0.86728462
84MP0003119_abnormal_digestive_system0.86689310
85MP0006276_abnormal_autonomic_nervous0.85701469
86MP0002277_abnormal_respiratory_mucosa0.85584224
87MP0005174_abnormal_tail_pigmentation0.84643124
88MP0003718_maternal_effect0.83630461
89MP0000049_abnormal_middle_ear0.81889943
90MP0001919_abnormal_reproductive_system0.81838880
91MP0000026_abnormal_inner_ear0.81388991
92MP0002734_abnormal_mechanical_nocicepti0.80993600
93MP0002928_abnormal_bile_duct0.80854600
94MP0002234_abnormal_pharynx_morphology0.80584972
95MP0001984_abnormal_olfaction0.79034210
96MP0000538_abnormal_urinary_bladder0.78452765
97MP0005448_abnormal_energy_balance0.77445776
98MP0009643_abnormal_urine_homeostasis0.75063737
99MP0001756_abnormal_urination0.73098782
100MP0009764_decreased_sensitivity_to0.72532982

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.30065362
2Pancreatic cysts (HP:0001737)4.06823009
3Pancreatic fibrosis (HP:0100732)3.64330276
4True hermaphroditism (HP:0010459)3.53181094
5Abnormality of the renal cortex (HP:0011035)3.40497620
6Pendular nystagmus (HP:0012043)3.35204929
7Molar tooth sign on MRI (HP:0002419)3.24861248
8Abnormality of midbrain morphology (HP:0002418)3.24861248
9Nephronophthisis (HP:0000090)3.06395360
10Abolished electroretinogram (ERG) (HP:0000550)3.02449175
11Renal cortical cysts (HP:0000803)2.91861595
12Abnormality of the renal medulla (HP:0100957)2.81632509
13Type II lissencephaly (HP:0007260)2.75944938
14Cystic liver disease (HP:0006706)2.75508355
15Keratoconus (HP:0000563)2.71290026
16Increased corneal curvature (HP:0100692)2.71290026
17Congenital sensorineural hearing impairment (HP:0008527)2.68944485
18Attenuation of retinal blood vessels (HP:0007843)2.66503735
19Abnormal rod and cone electroretinograms (HP:0008323)2.63869362
20Hyperglycinemia (HP:0002154)2.63550095
21Abnormality of glutamine family amino acid metabolism (HP:0010902)2.62242366
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59974902
23Abnormality of alanine metabolism (HP:0010916)2.59974902
24Hyperalaninemia (HP:0003348)2.59974902
25Decreased circulating renin level (HP:0003351)2.53185902
26Congenital, generalized hypertrichosis (HP:0004540)2.52686316
27Methylmalonic acidemia (HP:0002912)2.51824908
28Decreased central vision (HP:0007663)2.50109164
29Chorioretinal atrophy (HP:0000533)2.48019505
30Methylmalonic aciduria (HP:0012120)2.42597456
31Abnormality of glycine metabolism (HP:0010895)2.42008359
32Abnormality of serine family amino acid metabolism (HP:0010894)2.42008359
33Tubular atrophy (HP:0000092)2.40754785
34Genetic anticipation (HP:0003743)2.40537384
35Hyperglycinuria (HP:0003108)2.35850015
36Hyperventilation (HP:0002883)2.32366135
37Medial flaring of the eyebrow (HP:0010747)2.32109065
38Decreased electroretinogram (ERG) amplitude (HP:0000654)2.30728346
39Polydipsia (HP:0001959)2.28245203
40Abnormal drinking behavior (HP:0030082)2.28245203
41Stomach cancer (HP:0012126)2.27882793
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22854270
43Progressive cerebellar ataxia (HP:0002073)2.18628334
44Abnormality of vitamin B metabolism (HP:0004340)2.18049925
45Aplasia/Hypoplasia of the spleen (HP:0010451)2.17651334
46Chronic hepatic failure (HP:0100626)2.15509069
47Bile duct proliferation (HP:0001408)2.14403757
48Abnormal biliary tract physiology (HP:0012439)2.14403757
49Metabolic alkalosis (HP:0200114)2.13576347
50Pigmentary retinal degeneration (HP:0001146)2.12954653
51Sclerocornea (HP:0000647)2.12349215
52Confusion (HP:0001289)2.10788261
53Abnormality of the vitamin B12 metabolism (HP:0004341)2.09868576
54Asplenia (HP:0001746)2.07657176
55Glycosuria (HP:0003076)2.07499969
56Abnormality of urine glucose concentration (HP:0011016)2.07499969
57Acute encephalopathy (HP:0006846)2.06364514
58Furrowed tongue (HP:0000221)2.05264466
59Acute necrotizing encephalopathy (HP:0006965)2.04753464
60Hypothermia (HP:0002045)2.04147490
61Abnormality of the nasal septum (HP:0000419)2.03326564
62Abnormality of proline metabolism (HP:0010907)2.02466191
63Hydroxyprolinuria (HP:0003080)2.02466191
64Male pseudohermaphroditism (HP:0000037)1.98538594
65Gaze-evoked nystagmus (HP:0000640)1.98478823
66Hypoplasia of the uterus (HP:0000013)1.97279388
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97245715
68Aplasia/Hypoplasia of the tibia (HP:0005772)1.95846628
69Mitochondrial inheritance (HP:0001427)1.95534546
70Ketosis (HP:0001946)1.94898148
713-Methylglutaconic aciduria (HP:0003535)1.94630339
72Abnormality of serum amino acid levels (HP:0003112)1.93912421
73Agitation (HP:0000713)1.91008740
74Enlarged kidneys (HP:0000105)1.90839978
75Increased CSF lactate (HP:0002490)1.89333419
76Aplasia/hypoplasia of the uterus (HP:0008684)1.87570727
77Large for gestational age (HP:0001520)1.86895433
78Polyuria (HP:0000103)1.85548106
79Alkalosis (HP:0001948)1.84699023
80IgG deficiency (HP:0004315)1.84195144
81Progressive macrocephaly (HP:0004481)1.84020109
82Hemiparesis (HP:0001269)1.83706641
83Hypoplasia of the fovea (HP:0007750)1.82981268
84Aplasia/Hypoplasia of the fovea (HP:0008060)1.82981268
85Congenital hepatic fibrosis (HP:0002612)1.82785452
86Hypoplasia of the pons (HP:0012110)1.80781511
87Concave nail (HP:0001598)1.80758656
88Abnormal urine output (HP:0012590)1.80047818
89Bilateral microphthalmos (HP:0007633)1.80040495
90Inability to walk (HP:0002540)1.79736103
91Severe muscular hypotonia (HP:0006829)1.78493616
92Lissencephaly (HP:0001339)1.77048202
93Potter facies (HP:0002009)1.75222433
94Facial shape deformation (HP:0011334)1.75222433
95Abnormality of the pons (HP:0007361)1.75113590
96Optic disc pallor (HP:0000543)1.74315864
97Abnormal mitochondria in muscle tissue (HP:0008316)1.73309169
98Abnormality of renin-angiotensin system (HP:0000847)1.71784332
99Short hallux (HP:0010109)1.70977220
100Lethargy (HP:0001254)1.70644662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.26428200
2ADRBK23.45016581
3ACVR1B3.39982974
4GRK13.15113830
5MAP4K23.05702800
6WNK42.85451659
7TLK12.71910863
8TAOK32.68022898
9NUAK12.60625224
10ZAK2.54847040
11BMPR1B2.47738146
12PINK12.37058228
13WNK32.20566430
14TXK2.02500482
15STK391.93548779
16INSRR1.92643315
17OXSR11.91309277
18CASK1.90432129
19MAPK131.67891264
20PIK3CA1.55369320
21DAPK21.52124325
22MUSK1.17985594
23ADRBK11.17079928
24MAPKAPK31.16230172
25TNIK1.07847723
26IKBKB1.01071380
27PRKCG1.00191573
28MAP2K61.00022885
29CAMKK20.99824600
30MAP3K40.91075540
31PRKCE0.90960573
32PAK30.87060570
33TIE10.86235624
34BCKDK0.86041226
35PHKG20.83311355
36PHKG10.83311355
37PLK20.82789997
38FGFR20.82754420
39FLT30.82709976
40EPHA40.80020468
41GRK60.78254023
42DYRK20.75525619
43GRK70.73138375
44TEC0.72796050
45BRSK20.71412023
46MST40.70585470
47NTRK30.70492221
48GRK50.70487221
49PRKCQ0.67713394
50ITK0.67551664
51KIT0.67354451
52MKNK20.66254428
53VRK10.65067883
54PRKG20.63700380
55MAP2K20.63695137
56CSNK1G20.62918284
57STK38L0.62183594
58CAMK2A0.61769699
59CSNK1G10.61211749
60MAPKAPK50.60052381
61STK110.59190170
62PRKACA0.56840916
63CSNK1A10.55344095
64TGFBR10.54955537
65LIMK10.53729762
66CSNK1G30.53418939
67NLK0.53132756
68TRIM280.52479193
69PRKCA0.52352041
70STK160.51957536
71ERBB20.50788299
72MAP4K10.49950175
73PRKAA20.49485528
74NTRK20.48219185
75PTK2B0.46918812
76PRKCI0.46768436
77IGF1R0.46566365
78NME10.46201184
79VRK20.46176251
80MARK10.45429173
81MAP2K10.45244897
82SYK0.45243178
83AKT30.44113968
84MAP2K70.43339044
85PRKAA10.42887757
86FER0.41956031
87RPS6KA50.41778624
88PRKCZ0.40728951
89CSNK1A1L0.39647032
90PRKG10.37534277
91IRAK10.37051440
92EPHA30.36472623
93CAMK2D0.35720274
94LYN0.35152960
95PRKACG0.34218846
96CAMK10.33940780
97LCK0.33411698
98PKN10.32858101
99CHUK0.32419356
100IKBKE0.32304048

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005912.72804781
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.56040106
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.45694992
4Phototransduction_Homo sapiens_hsa047442.35041202
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.33437401
6Caffeine metabolism_Homo sapiens_hsa002322.27762966
7Nitrogen metabolism_Homo sapiens_hsa009102.27612915
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26266039
9Sulfur metabolism_Homo sapiens_hsa009202.21134860
10Chemical carcinogenesis_Homo sapiens_hsa052042.18153607
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.18029416
12Retinol metabolism_Homo sapiens_hsa008302.06843580
13Tryptophan metabolism_Homo sapiens_hsa003802.05973215
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02836793
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.99720401
16Butanoate metabolism_Homo sapiens_hsa006501.95986278
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.88486822
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.84182010
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80179673
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78722378
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62131202
22Nicotine addiction_Homo sapiens_hsa050331.61127205
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.60620867
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60347879
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58191599
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56683334
27* Fat digestion and absorption_Homo sapiens_hsa049751.48510094
28Ether lipid metabolism_Homo sapiens_hsa005651.48296795
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.48095109
30Oxidative phosphorylation_Homo sapiens_hsa001901.43025812
31Selenocompound metabolism_Homo sapiens_hsa004501.41691600
32Histidine metabolism_Homo sapiens_hsa003401.38908147
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.34580403
34Peroxisome_Homo sapiens_hsa041461.34232662
35Vitamin digestion and absorption_Homo sapiens_hsa049771.33079234
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31272782
37Arachidonic acid metabolism_Homo sapiens_hsa005901.30737600
38ABC transporters_Homo sapiens_hsa020101.25536050
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20563863
40Protein export_Homo sapiens_hsa030601.11047746
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.09879090
42Propanoate metabolism_Homo sapiens_hsa006401.07284691
43Sulfur relay system_Homo sapiens_hsa041221.04755149
44Fatty acid degradation_Homo sapiens_hsa000710.98654420
45Homologous recombination_Homo sapiens_hsa034400.98614999
46Taste transduction_Homo sapiens_hsa047420.98213601
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98140274
48Mineral absorption_Homo sapiens_hsa049780.98021382
49Parkinsons disease_Homo sapiens_hsa050120.93211611
50* Glycerolipid metabolism_Homo sapiens_hsa005610.93030818
51Olfactory transduction_Homo sapiens_hsa047400.92213176
52Morphine addiction_Homo sapiens_hsa050320.91772637
53Starch and sucrose metabolism_Homo sapiens_hsa005000.91245112
54Asthma_Homo sapiens_hsa053100.91043352
55Primary immunodeficiency_Homo sapiens_hsa053400.88572183
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88061927
57One carbon pool by folate_Homo sapiens_hsa006700.86939387
58Renin-angiotensin system_Homo sapiens_hsa046140.84534837
59RNA polymerase_Homo sapiens_hsa030200.80940133
60beta-Alanine metabolism_Homo sapiens_hsa004100.79940395
61Insulin secretion_Homo sapiens_hsa049110.79925210
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79140539
63Arginine biosynthesis_Homo sapiens_hsa002200.78343361
64Serotonergic synapse_Homo sapiens_hsa047260.77425976
65Bile secretion_Homo sapiens_hsa049760.77339705
66PPAR signaling pathway_Homo sapiens_hsa033200.75552621
67Complement and coagulation cascades_Homo sapiens_hsa046100.72330932
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68759396
69RNA degradation_Homo sapiens_hsa030180.65448515
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65275938
71Basal transcription factors_Homo sapiens_hsa030220.65249714
72Arginine and proline metabolism_Homo sapiens_hsa003300.64392438
73Fanconi anemia pathway_Homo sapiens_hsa034600.64332944
74* Metabolic pathways_Homo sapiens_hsa011000.63345816
75Alzheimers disease_Homo sapiens_hsa050100.62709278
76Type I diabetes mellitus_Homo sapiens_hsa049400.62354543
77Graft-versus-host disease_Homo sapiens_hsa053320.62309438
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61415834
79GABAergic synapse_Homo sapiens_hsa047270.61035389
80Cardiac muscle contraction_Homo sapiens_hsa042600.60948162
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59663738
82Glutamatergic synapse_Homo sapiens_hsa047240.58832894
83Circadian entrainment_Homo sapiens_hsa047130.58803978
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58675605
85Tyrosine metabolism_Homo sapiens_hsa003500.57348242
86Ovarian steroidogenesis_Homo sapiens_hsa049130.56047150
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53844658
88Autoimmune thyroid disease_Homo sapiens_hsa053200.53707108
89Allograft rejection_Homo sapiens_hsa053300.53409924
90Huntingtons disease_Homo sapiens_hsa050160.52066226
91Salivary secretion_Homo sapiens_hsa049700.49502782
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49146991
93Fatty acid biosynthesis_Homo sapiens_hsa000610.46313784
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42545385
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.42460050
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.42175137
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40630606
98Fatty acid metabolism_Homo sapiens_hsa012120.40460900
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40124684
100Steroid biosynthesis_Homo sapiens_hsa001000.39812604

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