MOGS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)5.24099854
2ribosomal small subunit assembly (GO:0000028)4.62837066
3DNA unwinding involved in DNA replication (GO:0006268)4.33741264
4viral transcription (GO:0019083)4.07884853
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.03817019
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.03817019
7mannose metabolic process (GO:0006013)4.03487709
8translational termination (GO:0006415)3.96252880
9tetrahydrofolate metabolic process (GO:0046653)3.88250362
10proline biosynthetic process (GO:0006561)3.71310664
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.69755308
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.67794880
13COPI coating of Golgi vesicle (GO:0048205)3.67183660
14Golgi transport vesicle coating (GO:0048200)3.67183660
15IMP biosynthetic process (GO:0006188)3.65261920
16translational elongation (GO:0006414)3.65015193
17pinocytosis (GO:0006907)3.63405690
18protein retention in ER lumen (GO:0006621)3.62146372
19protein targeting to ER (GO:0045047)3.59955848
20protein localization to endosome (GO:0036010)3.59167543
21cotranslational protein targeting to membrane (GO:0006613)3.55144564
22glycine metabolic process (GO:0006544)3.54209306
23maturation of SSU-rRNA (GO:0030490)3.49328762
24DNA strand elongation involved in DNA replication (GO:0006271)3.46366000
25hemidesmosome assembly (GO:0031581)3.43864640
26establishment of protein localization to endoplasmic reticulum (GO:0072599)3.43380051
27protein localization to endoplasmic reticulum (GO:0070972)3.40263254
28pteridine-containing compound biosynthetic process (GO:0042559)3.39684418
29basement membrane organization (GO:0071711)3.34528456
30DNA strand elongation (GO:0022616)3.32385034
31antigen processing and presentation of endogenous antigen (GO:0019883)3.31632350
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.31014233
33one-carbon metabolic process (GO:0006730)3.30808369
34cell-substrate junction assembly (GO:0007044)3.29253359
35IMP metabolic process (GO:0046040)3.26365877
36regulation of translational fidelity (GO:0006450)3.25740860
37folic acid metabolic process (GO:0046655)3.24942700
38nucleobase biosynthetic process (GO:0046112)3.23325495
39translational initiation (GO:0006413)3.21333689
40serine family amino acid biosynthetic process (GO:0009070)3.19668956
41pentose-phosphate shunt (GO:0006098)3.19620676
42protein localization to kinetochore (GO:0034501)3.18908161
43folic acid-containing compound metabolic process (GO:0006760)3.17685930
44regulation of cholesterol homeostasis (GO:2000188)3.17520844
45retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.17018724
46formation of translation preinitiation complex (GO:0001731)3.16850075
47cell-substrate adherens junction assembly (GO:0007045)3.15559038
48focal adhesion assembly (GO:0048041)3.15559038
49embryonic process involved in female pregnancy (GO:0060136)3.11364304
50regulation of extracellular matrix disassembly (GO:0010715)3.10865900
51apoptotic process involved in morphogenesis (GO:0060561)3.10195709
52L-serine metabolic process (GO:0006563)3.08205252
53adherens junction assembly (GO:0034333)3.07732816
54telomere maintenance via semi-conservative replication (GO:0032201)3.06972406
55viral life cycle (GO:0019058)3.06321429
56ribosomal small subunit biogenesis (GO:0042274)3.04843678
57activation of Rac GTPase activity (GO:0032863)3.01208137
58regulation of mammary gland epithelial cell proliferation (GO:0033599)3.00033027
59positive regulation of Cdc42 GTPase activity (GO:0043089)2.99897504
603-UTR-mediated mRNA stabilization (GO:0070935)2.98494533
61regulation of early endosome to late endosome transport (GO:2000641)2.97856771
62maternal placenta development (GO:0001893)2.95235947
63pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.94495536
64DNA replication initiation (GO:0006270)2.94070814
65cellular protein complex disassembly (GO:0043624)2.92915017
66modulation by symbiont of host cellular process (GO:0044068)2.89215244
67proline metabolic process (GO:0006560)2.85479164
68skin morphogenesis (GO:0043589)2.85465969
69negative regulation of fatty acid transport (GO:2000192)2.85120928
70response to laminar fluid shear stress (GO:0034616)2.83431572
71valine metabolic process (GO:0006573)2.83313101
72negative regulation of fibrinolysis (GO:0051918)2.82272475
73regulation of glucose import in response to insulin stimulus (GO:2001273)2.81504582
74negative regulation of RNA splicing (GO:0033119)2.81453627
75pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.79894325
76UMP metabolic process (GO:0046049)2.79894325
77pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.79894325
78UMP biosynthetic process (GO:0006222)2.79894325
79semaphorin-plexin signaling pathway (GO:0071526)2.78394032
80planar cell polarity pathway involved in neural tube closure (GO:0090179)2.76012737
81negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.75792244
82mitotic nuclear envelope disassembly (GO:0007077)2.75600905
83protein complex disassembly (GO:0043241)2.73519459
84NADPH regeneration (GO:0006740)2.73412358
85stress fiber assembly (GO:0043149)2.72396169
86low-density lipoprotein particle clearance (GO:0034383)2.71980556
87nuclear pore complex assembly (GO:0051292)2.69644465
88DNA deamination (GO:0045006)2.69448953
89glucose 6-phosphate metabolic process (GO:0051156)2.68868802
90pteridine-containing compound metabolic process (GO:0042558)2.68584765
91positive regulation of gamma-delta T cell activation (GO:0046645)2.67569763
92negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.67498489
93pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.66987623
94positive regulation of extracellular matrix organization (GO:1903055)2.66818176
95regulation of gamma-delta T cell differentiation (GO:0045586)2.65562200
96positive regulation of nuclease activity (GO:0032075)2.64741044
97protein carboxylation (GO:0018214)2.64426251
98peptidyl-glutamic acid carboxylation (GO:0017187)2.64426251
99negative regulation of cell size (GO:0045792)2.64290797
100serine family amino acid metabolic process (GO:0009069)2.63597305
101DNA duplex unwinding (GO:0032508)2.63015534
102epithelial cell differentiation involved in prostate gland development (GO:0060742)2.63007362
103protein localization to chromosome, centromeric region (GO:0071459)2.62622407
104erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.61076864
105L-phenylalanine metabolic process (GO:0006558)2.61076864
106negative regulation of phagocytosis (GO:0050765)2.60760671
107plasma lipoprotein particle assembly (GO:0034377)2.60387850
108DNA geometric change (GO:0032392)2.59623640
109barbed-end actin filament capping (GO:0051016)2.59567363
110desmosome organization (GO:0002934)2.59231515
111positive regulation of B cell differentiation (GO:0045579)2.58838141
112endoplasmic reticulum unfolded protein response (GO:0030968)2.58288887
113negative regulation of erythrocyte differentiation (GO:0045647)2.58098374
114negative regulation of viral release from host cell (GO:1902187)2.57371691
115protein-lipid complex assembly (GO:0065005)2.57238622
116T cell apoptotic process (GO:0070231)2.56889484
117nuclear-transcribed mRNA catabolic process (GO:0000956)2.56451382
118oxaloacetate metabolic process (GO:0006107)2.55891268
119activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.55650236
120positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.55479438
121modulation by virus of host process (GO:0019054)2.55371050
122nuclear pore organization (GO:0006999)2.55006821
123macromolecular complex disassembly (GO:0032984)2.54779597
124killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.54705167
125disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.54705167
126regulation of histone H3-K27 methylation (GO:0061085)2.54312255
127purine nucleobase biosynthetic process (GO:0009113)2.54005012
128regulation of extracellular matrix organization (GO:1903053)2.53868364
129urea cycle (GO:0000050)2.53386631
130cysteine metabolic process (GO:0006534)2.52957621
131regulation of cholesterol biosynthetic process (GO:0045540)2.51219290
132telomere maintenance via recombination (GO:0000722)2.50878576
133regulation of apoptotic cell clearance (GO:2000425)2.50720856
134epithelial cell-cell adhesion (GO:0090136)2.50646561
135nuclear envelope disassembly (GO:0051081)2.50401717
136membrane disassembly (GO:0030397)2.50401717
137imidazole-containing compound metabolic process (GO:0052803)2.49888692
138dosage compensation (GO:0007549)2.49749081
139apoptotic cell clearance (GO:0043277)2.49398262
140L-phenylalanine catabolic process (GO:0006559)2.49234351
141erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.49234351
1424-hydroxyproline metabolic process (GO:0019471)2.49012668
143lysine metabolic process (GO:0006553)2.48255365
144lysine catabolic process (GO:0006554)2.48255365
145ER-nucleus signaling pathway (GO:0006984)2.47573021
146negative regulation of mRNA metabolic process (GO:1903312)2.46793601
147regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46498297
148branching involved in mammary gland duct morphogenesis (GO:0060444)2.45584812
149mRNA catabolic process (GO:0006402)2.45582132
150negative regulation of cholesterol transport (GO:0032375)2.44934857
151negative regulation of sterol transport (GO:0032372)2.44934857
152regulation of nuclease activity (GO:0032069)2.43945005
153positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.43589942
154positive regulation of blood vessel endothelial cell migration (GO:0043536)2.43130522
155glucose catabolic process (GO:0006007)2.43052493
156RNA catabolic process (GO:0006401)2.42688364
157regulation of translational termination (GO:0006449)2.42496110
158very-low-density lipoprotein particle assembly (GO:0034379)2.42123616
159cellular response to epidermal growth factor stimulus (GO:0071364)2.41794424
160mitotic recombination (GO:0006312)2.41201012
161ribosomal large subunit biogenesis (GO:0042273)2.40765732
162NIK/NF-kappaB signaling (GO:0038061)2.39869963
163blood coagulation, intrinsic pathway (GO:0007597)2.39528271
164cytoskeletal anchoring at plasma membrane (GO:0007016)2.38986459
165hyaluronan catabolic process (GO:0030214)2.38946161
166cellular response to unfolded protein (GO:0034620)2.35854569
167response to muramyl dipeptide (GO:0032495)2.32173254
168urea metabolic process (GO:0019627)2.31355217
169regulation of integrin activation (GO:0033623)2.30144851
170regulation of type I interferon-mediated signaling pathway (GO:0060338)2.28619317
171hypotonic response (GO:0006971)2.28521869
172endodermal cell differentiation (GO:0035987)2.24199316
173cell adhesion mediated by integrin (GO:0033627)2.24091936
174modulation by virus of host morphology or physiology (GO:0019048)2.23839093
175activation of MAPKKK activity (GO:0000185)2.23714246
176peptidyl-proline hydroxylation (GO:0019511)2.23311539
177membrane protein ectodomain proteolysis (GO:0006509)2.21796399
178embryo implantation (GO:0007566)2.21481121
179glycosphingolipid catabolic process (GO:0046479)2.20268824
180GDP-mannose metabolic process (GO:0019673)2.18017947
181surfactant homeostasis (GO:0043129)2.17529430
182cellular response to virus (GO:0098586)2.16675630
183regulation of superoxide anion generation (GO:0032928)2.15889818
184thymic T cell selection (GO:0045061)2.15815507
185glutamine family amino acid biosynthetic process (GO:0009084)2.15666359
186cellular response to topologically incorrect protein (GO:0035967)2.15635708
187regulation of apoptotic process involved in morphogenesis (GO:1902337)2.14093217

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.24920456
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.16565544
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.75037153
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.26215223
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.11269511
6MYC_22102868_ChIP-Seq_BL_Human2.95812951
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.69951761
8* LXR_22292898_ChIP-Seq_THP-1_Human2.62952131
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.48754011
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44863701
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.40766050
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36941647
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.21766109
14VDR_21846776_ChIP-Seq_THP-1_Human2.21730316
15RACK7_27058665_Chip-Seq_MCF-7_Human2.18044318
16ZNF263_19887448_ChIP-Seq_K562_Human2.15367464
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.08888463
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05251101
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04499793
20RXR_22158963_ChIP-Seq_LIVER_Mouse2.01794269
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96140974
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95939306
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93810508
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93139834
25* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89334752
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86568798
27KDM2B_26808549_Chip-Seq_DND41_Human1.86243482
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83607175
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78877016
30XRN2_22483619_ChIP-Seq_HELA_Human1.78237168
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72111908
32SCL_19346495_ChIP-Seq_HPC-7_Human1.66691786
33GATA1_22025678_ChIP-Seq_K562_Human1.65891324
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.64133031
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64055406
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63262976
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.63230813
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62455475
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.62124181
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.60768651
41* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59061045
42CIITA_25753668_ChIP-Seq_RAJI_Human1.58486652
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58186160
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57383601
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.55119218
46AR_21909140_ChIP-Seq_LNCAP_Human1.55078834
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53880548
48KDM2B_26808549_Chip-Seq_K562_Human1.51103039
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.51051515
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50803860
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48818830
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46804886
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46439981
54FOXP3_21729870_ChIP-Seq_TREG_Human1.45724005
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44651594
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44541540
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43873652
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43854321
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43024874
60TCF7_22412390_ChIP-Seq_EML_Mouse1.42939895
61DCP1A_22483619_ChIP-Seq_HELA_Human1.42819625
62UTX_26944678_Chip-Seq_JUKART_Human1.42604237
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42168722
64MAF_26560356_Chip-Seq_TH1_Human1.41528582
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41054687
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40452023
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39849297
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39767413
69* VDR_23849224_ChIP-Seq_CD4+_Human1.39568780
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39118836
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38742993
72P68_20966046_ChIP-Seq_HELA_Human1.38526459
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37785310
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37746456
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37118738
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36502031
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.36312271
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35936984
79GABP_19822575_ChIP-Seq_HepG2_Human1.35445978
80* TET1_21451524_ChIP-Seq_MESCs_Mouse1.35053379
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33607119
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33596819
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33132637
84GABP_17652178_ChIP-ChIP_JURKAT_Human1.33089507
85KDM5A_27292631_Chip-Seq_BREAST_Human1.32920423
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.32353565
87NCOR1_26117541_ChIP-Seq_K562_Human1.31474783
88ATF3_27146783_Chip-Seq_COLON_Human1.30759413
89LXR_22158963_ChIP-Seq_LIVER_Mouse1.30099028
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.29230207
91VDR_24763502_ChIP-Seq_THP-1_Human1.28965174
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28885012
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26090056
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25237936
95MYB_26560356_Chip-Seq_TH1_Human1.25134929
96HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24469787
97KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23527050
98IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23045382
99SMC4_20622854_ChIP-Seq_HELA_Human1.22543648
100MYB_26560356_Chip-Seq_TH2_Human1.22488805
101SPI1_23547873_ChIP-Seq_NB4_Human1.22454450
102STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22137840
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22099492
104RUNX1_22412390_ChIP-Seq_EML_Mouse1.21051375
105TP53_22127205_ChIP-Seq_IMR90_Human1.20362680
106MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20191339
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19946745
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19526573
109HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19108987
110ERG_21242973_ChIP-ChIP_JURKAT_Human1.18827958
111CREB1_26743006_Chip-Seq_LNCaP_Human1.17538877
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16074996
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16057944
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15744793
115WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15550960
116SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15488625
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15281210
118E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15213846
119PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14351057
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14226598
121STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12946763
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12661695
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11987130
124HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11608978
125ELK3_25401928_ChIP-Seq_HUVEC_Human1.10768416
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10439934
127TTF2_22483619_ChIP-Seq_HELA_Human1.10218443
128MAF_26560356_Chip-Seq_TH2_Human1.10069007
129RUNX1_27514584_Chip-Seq_MCF-7_Human1.09912825
130GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09695967
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09284113
132UBF1/2_26484160_Chip-Seq_HMECs_Human1.09257900
133* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08785694
134STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06641765
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06204519
136SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06064519
137ELF1_20517297_ChIP-Seq_JURKAT_Human1.05917739
138* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05581909
139BCOR_27268052_Chip-Seq_Bcells_Human1.05468139
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04364599
141HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04267365
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03099001
143NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02882016
144CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02454142
145SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00751172
146NOTCH1_21737748_ChIP-Seq_TLL_Human1.00698127
147E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00040749
148TFEB_21752829_ChIP-Seq_HELA_Human0.99952462
149GATA1_19941827_ChIP-Seq_MEL_Mouse0.99745178
150POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98958997
151* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98868324
152* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98511713
153TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98489922
154TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98232897
155DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98096719
156E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97036660
157CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96873321
158P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96598682
159* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96236030
160KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96000181
161CLOCK_20551151_ChIP-Seq_293T_Human0.95856467
162MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95465324
163ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94471868

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.46151500
2MP0005451_abnormal_body_composition3.12216081
3MP0005058_abnormal_lysosome_morphology3.08777436
4MP0005360_urolithiasis3.05891197
5MP0008438_abnormal_cutaneous_collagen2.96901152
6MP0002396_abnormal_hematopoietic_system2.92058369
7MP0005365_abnormal_bile_salt2.66191625
8MP0003693_abnormal_embryo_hatching2.58846764
9MP0005085_abnormal_gallbladder_physiolo2.44150982
10MP0001849_ear_inflammation2.32353671
11MP0003300_gastrointestinal_ulcer2.30622813
12MP0010352_gastrointestinal_tract_polyps2.15316915
13MP0003172_abnormal_lysosome_physiology2.12947810
14MP0009840_abnormal_foam_cell2.08108517
15MP0003705_abnormal_hypodermis_morpholog2.07973098
16MP0003806_abnormal_nucleotide_metabolis2.07768566
17MP0003252_abnormal_bile_duct2.06003912
18MP0008260_abnormal_autophagy2.04998064
19MP0010094_abnormal_chromosome_stability1.97766839
20MP0004957_abnormal_blastocyst_morpholog1.97073052
21MP0003111_abnormal_nucleus_morphology1.96562806
22MP0004858_abnormal_nervous_system1.88602240
23MP0005083_abnormal_biliary_tract1.88365294
24MP0003453_abnormal_keratinocyte_physiol1.88310560
25MP0003191_abnormal_cellular_cholesterol1.85916229
26MP0005409_darkened_coat_color1.84650150
27MP0003763_abnormal_thymus_physiology1.83412026
28MP0004272_abnormal_basement_membrane1.82613512
29MP0006054_spinal_hemorrhage1.79671165
30MP0003436_decreased_susceptibility_to1.72578983
31MP0003077_abnormal_cell_cycle1.71367725
32MP0003091_abnormal_cell_migration1.70497295
33MP0004808_abnormal_hematopoietic_stem1.69006814
34MP0005464_abnormal_platelet_physiology1.66686480
35MP0001545_abnormal_hematopoietic_system1.65881108
36MP0005397_hematopoietic_system_phenotyp1.65881108
37MP0000490_abnormal_crypts_of1.65048581
38MP0004185_abnormal_adipocyte_glucose1.62955121
39MP0005257_abnormal_intraocular_pressure1.60803268
40MP0002166_altered_tumor_susceptibility1.59690978
41MP0008057_abnormal_DNA_replication1.58254541
42MP0002877_abnormal_melanocyte_morpholog1.55247808
43MP0001666_abnormal_nutrient_absorption1.52842913
44MP0000678_abnormal_parathyroid_gland1.52272876
45MP0000685_abnormal_immune_system1.52136809
46MP0010329_abnormal_lipoprotein_level1.50412433
47MP0002089_abnormal_postnatal_growth/wei1.49569998
48MP0000465_gastrointestinal_hemorrhage1.48044138
49MP0008875_abnormal_xenobiotic_pharmacok1.48034897
50MP0010307_abnormal_tumor_latency1.47684617
51MP0000609_abnormal_liver_physiology1.47371218
52MP0002796_impaired_skin_barrier1.47319346
53MP0002398_abnormal_bone_marrow1.45845068
54MP0001835_abnormal_antigen_presentation1.45318476
55MP0009333_abnormal_splenocyte_physiolog1.44899649
56MP0001348_abnormal_lacrimal_gland1.43658241
57MP0003303_peritoneal_inflammation1.42164913
58MP0005220_abnormal_exocrine_pancreas1.40359609
59MP0002060_abnormal_skin_morphology1.36245042
60MP0000689_abnormal_spleen_morphology1.35470896
61MP0003656_abnormal_erythrocyte_physiolo1.34257249
62MP0002722_abnormal_immune_system1.33311668
63MP0010155_abnormal_intestine_physiology1.29771586
64MP0001800_abnormal_humoral_immune1.28459526
65MP0001873_stomach_inflammation1.27180578
66MP0000598_abnormal_liver_morphology1.24658186
67MP0005501_abnormal_skin_physiology1.24272474
68MP0008007_abnormal_cellular_replicative1.23849769
69MP0002019_abnormal_tumor_incidence1.21612949
70MP0001730_embryonic_growth_arrest1.21427989
71MP0000703_abnormal_thymus_morphology1.20897569
72MP0003279_aneurysm1.18894229
73MP0005076_abnormal_cell_differentiation1.18754870
74MP0002429_abnormal_blood_cell1.16856502
75MP0000003_abnormal_adipose_tissue1.16318025
76MP0002138_abnormal_hepatobiliary_system1.16083453
77MP0005025_abnormal_response_to1.13597099
78MP0000716_abnormal_immune_system1.13519516
79MP0001958_emphysema1.11602156
80MP0003566_abnormal_cell_adhesion1.11156823
81MP0000350_abnormal_cell_proliferation1.09331220
82MP0002405_respiratory_system_inflammati1.08910439
83MP0003329_amyloid_beta_deposits1.08643508
84MP0005666_abnormal_adipose_tissue1.07692730
85MP0002998_abnormal_bone_remodeling1.07501083
86MP0005319_abnormal_enzyme/_coenzyme1.06629261
87MP0003866_abnormal_defecation1.06554569
88MP0002420_abnormal_adaptive_immunity1.06136543
89MP0005623_abnormal_meninges_morphology1.05749089
90MP0009278_abnormal_bone_marrow1.05393686
91MP0002452_abnormal_antigen_presenting1.05377338
92MP0000537_abnormal_urethra_morphology1.04219187
93MP0001819_abnormal_immune_cell1.03827643
94MP0001845_abnormal_inflammatory_respons1.03724302
95MP0004233_abnormal_muscle_weight1.03510555
96MP0010234_abnormal_vibrissa_follicle1.03499123
97MP0002723_abnormal_immune_serum1.03342224
98MP0004264_abnormal_extraembryonic_tissu1.03315345
99MP0005387_immune_system_phenotype1.03018402
100MP0001790_abnormal_immune_system1.03018402
101MP0001853_heart_inflammation1.02669597
102MP0000767_abnormal_smooth_muscle1.01879554
103MP0005375_adipose_tissue_phenotype1.01295414
104MP0001216_abnormal_epidermal_layer1.00218587
105MP0001533_abnormal_skeleton_physiology0.99171340
106MP0005000_abnormal_immune_tolerance0.98371798
107MP0008469_abnormal_protein_level0.98362517
108MP0003183_abnormal_peptide_metabolism0.97021817
109MP0002006_tumorigenesis0.95249599
110MP0009384_cardiac_valve_regurgitation0.94986639
111MP0000858_altered_metastatic_potential0.93727176
112MP0005621_abnormal_cell_physiology0.92546568
113MP0002419_abnormal_innate_immunity0.92027460
114MP0005023_abnormal_wound_healing0.91915069
115MP0005671_abnormal_response_to0.91878876
116MP0004947_skin_inflammation0.91857500
117MP0009931_abnormal_skin_appearance0.91447981
118MP0005275_abnormal_skin_tensile0.91230239
119MP0003868_abnormal_feces_composition0.90812690
120MP0002086_abnormal_extraembryonic_tissu0.90266129
121MP0002080_prenatal_lethality0.89394311
122MP0009643_abnormal_urine_homeostasis0.89341435
123MP0005075_abnormal_melanosome_morpholog0.88575018
124MP0004197_abnormal_fetal_growth/weight/0.88180241
125MP0000604_amyloidosis0.87353945
126MP0001661_extended_life_span0.84839743
127MP0005408_hypopigmentation0.84620577
128MP0000313_abnormal_cell_death0.83178981
129MP0000477_abnormal_intestine_morphology0.82874143
130MP0000733_abnormal_muscle_development0.82699290
131MP0009785_altered_susceptibility_to0.82604502
132MP0000467_abnormal_esophagus_morphology0.82193641
133MP0003283_abnormal_digestive_organ0.82084125
134MP0002933_joint_inflammation0.81627562
135MP0002896_abnormal_bone_mineralization0.81476306
136MP0009672_abnormal_birth_weight0.81078998
137MP0009763_increased_sensitivity_to0.80695057
138MP0001915_intracranial_hemorrhage0.79138386
139MP0001764_abnormal_homeostasis0.78455780
140MP0008058_abnormal_DNA_repair0.78150917
141MP0002088_abnormal_embryonic_growth/wei0.77678650
142MP0003984_embryonic_growth_retardation0.77418634
143MP0001697_abnormal_embryo_size0.76275813
144MP0002098_abnormal_vibrissa_morphology0.75609724
145MP0004782_abnormal_surfactant_physiolog0.74502898
146MP0004381_abnormal_hair_follicle0.74204509
147MP0003448_altered_tumor_morphology0.74141548
148MP0003075_altered_response_to0.69890056
149MP0000751_myopathy0.68671197
150MP0000566_synostosis0.68528666
151MP0010630_abnormal_cardiac_muscle0.68114900
152MP0002254_reproductive_system_inflammat0.66747990
153MP0001851_eye_inflammation0.66337242
154MP0002249_abnormal_larynx_morphology0.65870362
155MP0003795_abnormal_bone_structure0.64985951

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)4.04982976
2Protrusio acetabuli (HP:0003179)3.83172115
3Abnormality of cells of the erythroid lineage (HP:0012130)3.69727228
4Abnormal number of erythroid precursors (HP:0012131)3.64777645
5Deep venous thrombosis (HP:0002625)3.58862558
6Premature rupture of membranes (HP:0001788)3.52433266
7Reticulocytopenia (HP:0001896)3.39841254
8Abnormal platelet volume (HP:0011876)3.39742212
9Increased mean platelet volume (HP:0011877)3.28089017
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.24368728
11Hypobetalipoproteinemia (HP:0003563)3.20137825
12Petechiae (HP:0000967)3.13160637
13Prolonged bleeding time (HP:0003010)2.94893941
14Vertebral compression fractures (HP:0002953)2.92722852
15Flat acetabular roof (HP:0003180)2.92598495
16Abnormality of the common coagulation pathway (HP:0010990)2.91175711
17Abnormality of the intrinsic pathway (HP:0010989)2.89444746
18Intrahepatic cholestasis (HP:0001406)2.88529727
19Abnormality of aromatic amino acid family metabolism (HP:0004338)2.86717420
20Abnormal platelet function (HP:0011869)2.86387760
21Impaired platelet aggregation (HP:0003540)2.86387760
22Menorrhagia (HP:0000132)2.85051719
23Hemorrhage of the eye (HP:0011885)2.83995210
24Cerebral aneurysm (HP:0004944)2.80619132
25Abnormality of pyrimidine metabolism (HP:0004353)2.79401693
26Thin bony cortex (HP:0002753)2.77023612
27Chronic otitis media (HP:0000389)2.71376999
28Gingival bleeding (HP:0000225)2.70482454
29Epistaxis (HP:0000421)2.69140846
30Xanthomatosis (HP:0000991)2.66381366
31Broad face (HP:0000283)2.63580983
32Cervical subluxation (HP:0003308)2.61668824
33Ulnar bowing (HP:0003031)2.60390831
34Spastic diplegia (HP:0001264)2.59347336
35Aplastic anemia (HP:0001915)2.50611277
36Abnormality of reticulocytes (HP:0004312)2.48258236
37IgM deficiency (HP:0002850)2.48115382
38Atrophic scars (HP:0001075)2.46029800
39Abnormality of T cell physiology (HP:0011840)2.41645018
40Hypoglycemic coma (HP:0001325)2.41600504
41Poikilocytosis (HP:0004447)2.41164023
42Achilles tendon contracture (HP:0001771)2.38825953
43Recurrent viral infections (HP:0004429)2.38720201
44Abnormality of the Achilles tendon (HP:0005109)2.31919088
45Prolonged partial thromboplastin time (HP:0003645)2.31099474
46Joint hemorrhage (HP:0005261)2.30982833
47Acanthocytosis (HP:0001927)2.29951773
48Disproportionate tall stature (HP:0001519)2.28686148
49Oral leukoplakia (HP:0002745)2.28097716
50Fragile skin (HP:0001030)2.27503872
51Asymmetry of the thorax (HP:0001555)2.21515594
52Biconcave vertebral bodies (HP:0004586)2.21305959
53Upper limb amyotrophy (HP:0009129)2.21119474
54Distal upper limb amyotrophy (HP:0007149)2.21119474
55Distal lower limb amyotrophy (HP:0008944)2.21107197
56Abnormality of sulfur amino acid metabolism (HP:0004339)2.20634362
57Pallor (HP:0000980)2.18546383
58Abnormality of T cells (HP:0002843)2.17573092
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.15717440
60Macrocytic anemia (HP:0001972)2.15146658
61Complement deficiency (HP:0004431)2.14786401
62Blue sclerae (HP:0000592)2.13964247
63Dysostosis multiplex (HP:0000943)2.13378088
64Abnormality of iron homeostasis (HP:0011031)2.10009444
65Increased connective tissue (HP:0009025)2.08170591
66Hepatocellular carcinoma (HP:0001402)2.06656527
67Increased serum ferritin (HP:0003281)2.05638677
68Purpura (HP:0000979)2.04749443
69Abnormality of complement system (HP:0005339)2.04597896
70Panhypogammaglobulinemia (HP:0003139)2.04157473
71Abnormality of endocrine pancreas physiology (HP:0012093)2.03773626
72Abnormality of the pancreatic islet cells (HP:0006476)2.03773626
73Multiple enchondromatosis (HP:0005701)2.00670940
74Abnormality of transition element cation homeostasis (HP:0011030)1.99651315
75Late onset (HP:0003584)1.98806284
76Gastrointestinal inflammation (HP:0004386)1.97983693
77Polygenic inheritance (HP:0010982)1.97836717
78Aneurysm (HP:0002617)1.96834924
79Reticulocytosis (HP:0001923)1.96742789
80Abnormality of carpal bone ossification (HP:0006257)1.96064462
81Mucopolysacchariduria (HP:0008155)1.95043651
82Urinary glycosaminoglycan excretion (HP:0003541)1.95043651
83Hyperammonemia (HP:0001987)1.94770392
84Hypolipoproteinemia (HP:0010981)1.94328682
85Nasal polyposis (HP:0100582)1.94080977
86J-shaped sella turcica (HP:0002680)1.93682884
87Hyperbilirubinemia (HP:0002904)1.93561769
88Abnormal ossification of hand bones (HP:0005921)1.91353924
89Long palpebral fissure (HP:0000637)1.91330980
90Ankyloglossia (HP:0010296)1.90831258
91Thrombophlebitis (HP:0004418)1.90266474
92Colitis (HP:0002583)1.89141580
93Dilatation of the ascending aorta (HP:0005111)1.88346475
9411 pairs of ribs (HP:0000878)1.87847980
95Increased density of long bones (HP:0006392)1.87830835
96Ketosis (HP:0001946)1.87300401
97Shallow orbits (HP:0000586)1.86867445
98Arterial tortuosity (HP:0005116)1.86610438
99T lymphocytopenia (HP:0005403)1.86395100
100Hyperlipoproteinemia (HP:0010980)1.86232657
101Wormian bones (HP:0002645)1.85783391
102Mitral regurgitation (HP:0001653)1.85317528
103Microretrognathia (HP:0000308)1.84348926
104Basal cell carcinoma (HP:0002671)1.84146659
105Abnormal foot bone ossification (HP:0010675)1.83505811
106Spontaneous hematomas (HP:0007420)1.83164051
107Syringomyelia (HP:0003396)1.83027894
108Spinal cord lesions (HP:0100561)1.83027894
109Abnormality of the acetabulum (HP:0003170)1.82216708
110Inflammation of the large intestine (HP:0002037)1.81708549
111Eczematoid dermatitis (HP:0000976)1.81541352
112Myocardial infarction (HP:0001658)1.81449723
113Distal lower limb muscle weakness (HP:0009053)1.81244967
114Systemic lupus erythematosus (HP:0002725)1.80061968
115Abnormality of oral frenula (HP:0000190)1.79892726
116Hyperacusis (HP:0010780)1.79337729
117Hypochromic anemia (HP:0001931)1.79107200
118Centrally nucleated skeletal muscle fibers (HP:0003687)1.78640516
119Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78285004
120Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78285004
121Abnormality of polysaccharide metabolism (HP:0011012)1.78285004
122Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.77176334
123Recurrent fungal infections (HP:0002841)1.76967284
124Abnormality of nucleobase metabolism (HP:0010932)1.76962729
125Cellulitis (HP:0100658)1.76039236
126Cupped ribs (HP:0000887)1.75589263
127Bladder diverticulum (HP:0000015)1.75443510
128Coxa vara (HP:0002812)1.75418619
129Selective tooth agenesis (HP:0001592)1.73807908
130Severe short stature (HP:0003510)1.73186619
131Stridor (HP:0010307)1.73032748
132Premature skin wrinkling (HP:0100678)1.72827545
133Fat malabsorption (HP:0002630)1.72741924
134Poikiloderma (HP:0001029)1.72359272
135Vascular tortuosity (HP:0004948)1.72250389
136Elevated erythrocyte sedimentation rate (HP:0003565)1.72239853
137Short nail (HP:0001799)1.72022710
138Abnormality of the nasal mucosa (HP:0000433)1.71801460
139Emphysema (HP:0002097)1.71785188
140Abnormality of the heme biosynthetic pathway (HP:0010472)1.70837613
141Abnormality of methionine metabolism (HP:0010901)1.70835614
142Abnormality of the distal phalanges of the toes (HP:0010182)1.69990898
143Thoracolumbar scoliosis (HP:0002944)1.69973650
144Nonimmune hydrops fetalis (HP:0001790)1.69637290
145Interstitial pulmonary disease (HP:0006530)1.69029881
146Periodontitis (HP:0000704)1.69022195
147Elbow flexion contracture (HP:0002987)1.68969097
148Thoracic kyphosis (HP:0002942)1.68617991
149Pancreatic islet-cell hyperplasia (HP:0004510)1.67892677
150Metaphyseal cupping (HP:0003021)1.67540454
151Back pain (HP:0003418)1.67074219
152Abnormality of T cell number (HP:0011839)1.66348668
153Advanced eruption of teeth (HP:0006288)1.66165146
154Reduced antithrombin III activity (HP:0001976)1.65847651
155Abnormality of macrophages (HP:0004311)1.65550938
156Abnormality of the fingertips (HP:0001211)1.65542922
157Mitral valve prolapse (HP:0001634)1.65354714
158Entropion (HP:0000621)1.64798032
159Colon cancer (HP:0003003)1.64430142
160Abnormal cartilage morphology (HP:0002763)1.64132493
161Insomnia (HP:0100785)1.62354989
162High pitched voice (HP:0001620)1.62191116
163Pustule (HP:0200039)1.62089362
164Aortic dissection (HP:0002647)1.61849174
165Hand muscle atrophy (HP:0009130)1.61803840
166Hypoplasia of the thymus (HP:0000778)1.61193113
167Increased variability in muscle fiber diameter (HP:0003557)1.61166627
168Verrucae (HP:0200043)1.60932177
169Bone pain (HP:0002653)1.60898375
170Obstructive sleep apnea (HP:0002870)1.60659561
171Osteolytic defects of the phalanges of the hand (HP:0009771)1.60611953
172Osteolytic defects of the hand bones (HP:0009699)1.60611953
173Mildly elevated creatine phosphokinase (HP:0008180)1.60220699
174Joint stiffness (HP:0001387)1.59769206
175Malnutrition (HP:0004395)1.59486566
176Trismus (HP:0000211)1.59336056
177Hypercholesterolemia (HP:0003124)1.57825614
178Natal tooth (HP:0000695)1.57791791
179Genu recurvatum (HP:0002816)1.56429291
180Abnormality of the distal phalanx of the thumb (HP:0009617)1.55506825
181Segmental peripheral demyelination/remyelination (HP:0003481)1.55187766
182Cerebral inclusion bodies (HP:0100314)1.55145274
183Abnormal gallbladder physiology (HP:0012438)1.54112413
184Cholecystitis (HP:0001082)1.54112413
185Dislocated radial head (HP:0003083)1.53829512

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.93752993
2PKN23.86016116
3TRIB33.82576486
4SMG13.59804434
5PRPF4B3.11458016
6MAP4K13.04691450
7ERN13.01684707
8MAP3K102.89858298
9ICK2.74209313
10SCYL22.47012623
11CDC72.42139196
12NME22.11364696
13EPHA21.95698755
14FLT31.89516961
15TAOK31.83803263
16MAP2K31.80484742
17PASK1.72961218
18JAK31.69187912
19NEK21.63039205
20ZAP701.61965261
21PTK61.61029345
22WEE11.59311789
23LRRK21.58580012
24BTK1.56030150
25CDK121.52168930
26BCKDK1.51974285
27CDK41.49963274
28RPS6KB21.49358759
29FGFR41.46360470
30MAP3K131.42117699
31GRK61.42043180
32STK101.41264409
33TYK21.38748331
34RPS6KA41.34678101
35SIK11.32316197
36TSSK61.30404688
37MAP3K81.23848213
38EIF2AK11.17965507
39TAOK21.13027763
40CDC42BPA1.12526212
41MAP3K141.10985949
42EPHB11.10381142
43PIM11.09043731
44ACVR1B1.08533570
45KSR21.05218797
46PTK21.01003602
47ITK1.00243297
48EIF2AK30.99847528
49CDK70.99827796
50RIPK40.98797057
51TEC0.98216926
52TESK20.97144753
53MAP3K110.96847295
54CDK60.96502894
55PDPK10.95360137
56PRKD20.94248360
57KIT0.94097404
58TGFBR10.93981847
59MARK20.92373733
60MAP3K10.91638387
61PAK40.91598594
62ALK0.89983514
63CSF1R0.88245620
64ARAF0.86957986
65BRD40.85174196
66ATR0.83987309
67MAPK110.83958767
68JAK20.82953268
69TESK10.82936969
70TBK10.82639571
71KDR0.82509472
72DDR20.81979746
73SYK0.81317293
74NTRK10.80578613
75MET0.80153319
76RPS6KA20.79602552
77PIM20.79163921
78BMX0.77829974
79LATS20.75703160
80AURKB0.74829055
81MST1R0.74467355
82TYRO30.73393562
83BRSK20.72670978
84SIK20.72137006
85LMTK20.72035295
86MAP3K60.69172117
87TTN0.68890391
88BLK0.66247614
89STK40.65657176
90BUB10.63854755
91MTOR0.63667492
92PAK20.61998997
93MAP3K30.61817085
94LCK0.60433807
95TLK10.59726566
96MAP2K20.59509643
97ILK0.58643539
98HIPK20.57964727
99CHEK10.54683045
100PDK10.53584657
101IRAK40.53439299
102TTK0.53393243
103JAK10.53332842
104TAOK10.52646475
105PRKG20.52315213
106PDGFRA0.52141952
107TXK0.51302368
108BRAF0.49428148
109MAP3K70.49227334
110IRAK20.48053928
111NEK90.47954048
112HCK0.47484285
113DYRK1B0.46552647
114SIK30.46376915
115RPS6KA60.45814371
116PDGFRB0.45679442
117TGFBR20.43311780
118RPS6KC10.42995668
119RPS6KL10.42995668
120PLK10.42453052
121CHUK0.41915833
122IRAK30.41696607
123CSNK2A20.41120270
124RET0.40380814
125CSK0.40353268
126LYN0.39555397
127CDK20.39309957
128PRKD30.39209890
129FGFR30.38964363
130MAPKAPK30.38501077
131CLK10.38377129
132MOS0.37931644
133IKBKE0.37272788
134MAP3K20.37035928
135MAPK40.36796556
136DYRK30.36657488
137CDK90.36526642
138PIK3CG0.35996851
139MAPKAPK20.35553704
140ATM0.35381555
141RIPK10.35202405
142MAPK120.33860954
143MELK0.33430465
144FGR0.31468594

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.53079923
2DNA replication_Homo sapiens_hsa030303.51854694
3Ribosome_Homo sapiens_hsa030102.54849805
4Mismatch repair_Homo sapiens_hsa034302.18519678
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.14661061
6Selenocompound metabolism_Homo sapiens_hsa004502.13781730
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.12701627
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.08265272
9Cyanoamino acid metabolism_Homo sapiens_hsa004601.89161545
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81900663
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.72734327
12Drug metabolism - other enzymes_Homo sapiens_hsa009831.72172407
13Base excision repair_Homo sapiens_hsa034101.72078348
14Fructose and mannose metabolism_Homo sapiens_hsa000511.71311973
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70552693
16Sulfur relay system_Homo sapiens_hsa041221.62753097
17Spliceosome_Homo sapiens_hsa030401.62698962
18Notch signaling pathway_Homo sapiens_hsa043301.58549780
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50213386
20Pancreatic cancer_Homo sapiens_hsa052121.50209885
21RNA transport_Homo sapiens_hsa030131.49954025
22VEGF signaling pathway_Homo sapiens_hsa043701.48544865
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46961650
24Prion diseases_Homo sapiens_hsa050201.45211674
25Biosynthesis of amino acids_Homo sapiens_hsa012301.43508869
26Nitrogen metabolism_Homo sapiens_hsa009101.43471220
27Antigen processing and presentation_Homo sapiens_hsa046121.38571961
28Complement and coagulation cascades_Homo sapiens_hsa046101.38460641
29* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.38417640
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35641346
31Pentose phosphate pathway_Homo sapiens_hsa000301.34117828
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.33906215
33Pyrimidine metabolism_Homo sapiens_hsa002401.31921441
34Arginine biosynthesis_Homo sapiens_hsa002201.31402981
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.26261626
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26235568
37Folate biosynthesis_Homo sapiens_hsa007901.23787816
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21265050
39Lysine degradation_Homo sapiens_hsa003101.21107841
40Endometrial cancer_Homo sapiens_hsa052131.20426999
41Tryptophan metabolism_Homo sapiens_hsa003801.19698441
42Fatty acid degradation_Homo sapiens_hsa000711.19627438
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19089678
44Nucleotide excision repair_Homo sapiens_hsa034201.17913692
45Focal adhesion_Homo sapiens_hsa045101.15614814
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13995293
47Osteoclast differentiation_Homo sapiens_hsa043801.11777017
48ECM-receptor interaction_Homo sapiens_hsa045121.11381229
49Primary immunodeficiency_Homo sapiens_hsa053401.09861667
50Cell cycle_Homo sapiens_hsa041101.09839405
51Systemic lupus erythematosus_Homo sapiens_hsa053221.06751694
52Amoebiasis_Homo sapiens_hsa051461.06387694
53Lysosome_Homo sapiens_hsa041421.05174897
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.04682029
55Staphylococcus aureus infection_Homo sapiens_hsa051501.04676872
56Carbon metabolism_Homo sapiens_hsa012001.04158851
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03543010
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03455975
59Hepatitis C_Homo sapiens_hsa051601.03399767
60Proteoglycans in cancer_Homo sapiens_hsa052051.02661135
61Homologous recombination_Homo sapiens_hsa034401.02628455
62Renal cell carcinoma_Homo sapiens_hsa052111.01995048
63Leukocyte transendothelial migration_Homo sapiens_hsa046701.00929019
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98632983
65* N-Glycan biosynthesis_Homo sapiens_hsa005100.97186879
66TNF signaling pathway_Homo sapiens_hsa046680.96379540
67mTOR signaling pathway_Homo sapiens_hsa041500.96353397
68Influenza A_Homo sapiens_hsa051640.94932910
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94689418
70Insulin signaling pathway_Homo sapiens_hsa049100.94265890
71Chronic myeloid leukemia_Homo sapiens_hsa052200.93306561
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92682998
73Caffeine metabolism_Homo sapiens_hsa002320.90067009
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89392561
75Glioma_Homo sapiens_hsa052140.88308376
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87992589
77Fat digestion and absorption_Homo sapiens_hsa049750.87894928
78Prostate cancer_Homo sapiens_hsa052150.87757781
79ErbB signaling pathway_Homo sapiens_hsa040120.87537633
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.86155007
81Viral carcinogenesis_Homo sapiens_hsa052030.83942385
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82966546
83Acute myeloid leukemia_Homo sapiens_hsa052210.82577969
84Shigellosis_Homo sapiens_hsa051310.79582302
85MicroRNAs in cancer_Homo sapiens_hsa052060.79204092
86Prolactin signaling pathway_Homo sapiens_hsa049170.77339379
87ABC transporters_Homo sapiens_hsa020100.77282509
88Starch and sucrose metabolism_Homo sapiens_hsa005000.77260270
89Herpes simplex infection_Homo sapiens_hsa051680.76449875
90Galactose metabolism_Homo sapiens_hsa000520.75609332
91HIF-1 signaling pathway_Homo sapiens_hsa040660.75376417
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75277364
93Legionellosis_Homo sapiens_hsa051340.75106782
94beta-Alanine metabolism_Homo sapiens_hsa004100.74729884
95Measles_Homo sapiens_hsa051620.74338798
96Peroxisome_Homo sapiens_hsa041460.74177350
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74130193
98Protein export_Homo sapiens_hsa030600.71552624
99Leishmaniasis_Homo sapiens_hsa051400.71149453
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70670959
101B cell receptor signaling pathway_Homo sapiens_hsa046620.70423711
102RNA degradation_Homo sapiens_hsa030180.69728868
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69407256
104Inositol phosphate metabolism_Homo sapiens_hsa005620.69170693
105Small cell lung cancer_Homo sapiens_hsa052220.67843118
106Endocytosis_Homo sapiens_hsa041440.67605401
107Non-homologous end-joining_Homo sapiens_hsa034500.67272670
108GnRH signaling pathway_Homo sapiens_hsa049120.67231905
109Adherens junction_Homo sapiens_hsa045200.67119834
110Colorectal cancer_Homo sapiens_hsa052100.66970498
111Choline metabolism in cancer_Homo sapiens_hsa052310.66500293
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.66043750
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65701733
114Histidine metabolism_Homo sapiens_hsa003400.65223730
115Pertussis_Homo sapiens_hsa051330.64773537
116T cell receptor signaling pathway_Homo sapiens_hsa046600.64708656
117Tuberculosis_Homo sapiens_hsa051520.63395478
118AMPK signaling pathway_Homo sapiens_hsa041520.63142839
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63120246
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.63018729
121Viral myocarditis_Homo sapiens_hsa054160.62200003
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.61458672
123p53 signaling pathway_Homo sapiens_hsa041150.61079419
124Thyroid cancer_Homo sapiens_hsa052160.60961792
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.59960721
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58600035
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.58546740
128Renin-angiotensin system_Homo sapiens_hsa046140.58393592
129Hepatitis B_Homo sapiens_hsa051610.58392931
130Non-small cell lung cancer_Homo sapiens_hsa052230.58196212
131PPAR signaling pathway_Homo sapiens_hsa033200.57806108
132Salmonella infection_Homo sapiens_hsa051320.57690100
133Estrogen signaling pathway_Homo sapiens_hsa049150.57230409
134mRNA surveillance pathway_Homo sapiens_hsa030150.57115793
135Apoptosis_Homo sapiens_hsa042100.57005789
136Malaria_Homo sapiens_hsa051440.54937216
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54558277
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53669844
139Vitamin digestion and absorption_Homo sapiens_hsa049770.53284613
140Pyruvate metabolism_Homo sapiens_hsa006200.53092306
141Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53085006
142HTLV-I infection_Homo sapiens_hsa051660.52031173
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50366040
144Chemical carcinogenesis_Homo sapiens_hsa052040.49578143
145Hematopoietic cell lineage_Homo sapiens_hsa046400.49325784
146Bladder cancer_Homo sapiens_hsa052190.49247531
147Glutathione metabolism_Homo sapiens_hsa004800.49155758
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48741922
149Toxoplasmosis_Homo sapiens_hsa051450.48479865
150Insulin resistance_Homo sapiens_hsa049310.48324112
151Sphingolipid metabolism_Homo sapiens_hsa006000.47746755
152Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47604513
153Phenylalanine metabolism_Homo sapiens_hsa003600.47304065
154Epstein-Barr virus infection_Homo sapiens_hsa051690.47078970
155Other glycan degradation_Homo sapiens_hsa005110.46093217
156Platelet activation_Homo sapiens_hsa046110.45586202
157Fatty acid metabolism_Homo sapiens_hsa012120.45565230
158Propanoate metabolism_Homo sapiens_hsa006400.44715216
159Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43884348
160Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43346013
161Bile secretion_Homo sapiens_hsa049760.42451629
162Arginine and proline metabolism_Homo sapiens_hsa003300.42322311
163Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42043512

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