MOK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.30420569
2axonemal dynein complex assembly (GO:0070286)7.86569117
3epithelial cilium movement (GO:0003351)7.49146274
4cilium movement (GO:0003341)7.30725841
5piRNA metabolic process (GO:0034587)7.08533829
6fusion of sperm to egg plasma membrane (GO:0007342)6.95196739
7sperm motility (GO:0030317)6.83109689
8motile cilium assembly (GO:0044458)6.77027959
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.51120674
10sperm-egg recognition (GO:0035036)6.37763528
11regulation of cilium movement (GO:0003352)6.34731564
12binding of sperm to zona pellucida (GO:0007339)6.19265917
13multicellular organism reproduction (GO:0032504)6.09893735
14acrosome reaction (GO:0007340)5.84393913
15cell wall macromolecule catabolic process (GO:0016998)5.77467125
16cell wall macromolecule metabolic process (GO:0044036)5.77467125
17male meiosis (GO:0007140)5.65009975
18cell-cell recognition (GO:0009988)5.61417754
19spermatid development (GO:0007286)5.61064178
20acrosome assembly (GO:0001675)5.56804970
21plasma membrane fusion (GO:0045026)5.37860954
22synaptonemal complex organization (GO:0070193)5.23830178
23synaptonemal complex assembly (GO:0007130)5.05394678
24reproduction (GO:0000003)4.88714868
25axoneme assembly (GO:0035082)4.68072744
26DNA methylation involved in gamete generation (GO:0043046)4.67562232
27microtubule depolymerization (GO:0007019)4.50368546
28ventricular system development (GO:0021591)4.49669851
29single fertilization (GO:0007338)4.49253339
30microtubule severing (GO:0051013)4.47945474
31negative regulation of inclusion body assembly (GO:0090084)4.40871016
32fertilization (GO:0009566)4.16729696
33regulation of microtubule-based movement (GO:0060632)4.15570102
34spermatogenesis (GO:0007283)4.02614413
35male gamete generation (GO:0048232)4.01764117
36protein polyglutamylation (GO:0018095)3.99699231
37male meiosis I (GO:0007141)3.98423116
38protein localization to cilium (GO:0061512)3.87818424
39behavioral response to nicotine (GO:0035095)3.87037107
40meiotic nuclear division (GO:0007126)3.84854151
41intraciliary transport (GO:0042073)3.81739472
42gamete generation (GO:0007276)3.79257359
43left/right axis specification (GO:0070986)3.76151514
44regulation of inclusion body assembly (GO:0090083)3.74860440
45regulation of meiosis I (GO:0060631)3.58355121
46chromosome organization involved in meiosis (GO:0070192)3.58353553
47germ cell development (GO:0007281)3.56624276
48meiotic cell cycle (GO:0051321)3.50771500
49nonmotile primary cilium assembly (GO:0035058)3.50426388
50nucleoside diphosphate phosphorylation (GO:0006165)3.46094735
51meiosis I (GO:0007127)3.43778955
52lens fiber cell development (GO:0070307)3.43071076
53sperm capacitation (GO:0048240)3.39408565
54GTP biosynthetic process (GO:0006183)3.33818628
55chaperone-mediated protein complex assembly (GO:0051131)3.30615366
56cellular process involved in reproduction in multicellular organism (GO:0022412)3.27679277
57cornea development in camera-type eye (GO:0061303)3.27265191
58cilium organization (GO:0044782)3.25624502
59calcium ion-dependent exocytosis (GO:0017156)3.24002489
60UTP biosynthetic process (GO:0006228)3.22153421
61microtubule bundle formation (GO:0001578)3.19337610
62smoothened signaling pathway (GO:0007224)3.19080995
63microtubule-based movement (GO:0007018)3.16315884
64single strand break repair (GO:0000012)3.15321637
65cilium assembly (GO:0042384)3.13193732
66cilium morphogenesis (GO:0060271)3.12236207
67regulation of centriole replication (GO:0046599)3.09772696
68negative regulation of organelle assembly (GO:1902116)3.06281776
69gene silencing by RNA (GO:0031047)3.05738781
70cell recognition (GO:0008037)3.03587000
71retinal ganglion cell axon guidance (GO:0031290)2.99044906
72photoreceptor cell maintenance (GO:0045494)2.94240630
73meiotic cell cycle process (GO:1903046)2.93703011
74fucose catabolic process (GO:0019317)2.92743350
75L-fucose metabolic process (GO:0042354)2.92743350
76L-fucose catabolic process (GO:0042355)2.92743350
77multicellular organismal reproductive process (GO:0048609)2.92192447
78microtubule polymerization or depolymerization (GO:0031109)2.90864217
79determination of left/right symmetry (GO:0007368)2.89524610
80retinal cone cell development (GO:0046549)2.89214922
81DNA replication-dependent nucleosome assembly (GO:0006335)2.81648976
82DNA replication-dependent nucleosome organization (GO:0034723)2.81648976
83regulation of spindle checkpoint (GO:0090231)2.78709879
84guanosine-containing compound biosynthetic process (GO:1901070)2.77377700
85dopamine transport (GO:0015872)2.77308840
86response to pheromone (GO:0019236)2.77260479
87cell projection assembly (GO:0030031)2.77197160
88limb bud formation (GO:0060174)2.76150341
89nuclear pore complex assembly (GO:0051292)2.74065469
90startle response (GO:0001964)2.72789423
91centriole assembly (GO:0098534)2.71320726
92chromosome condensation (GO:0030261)2.70603627
93neural tube formation (GO:0001841)2.70393395
94cellular component assembly involved in morphogenesis (GO:0010927)2.69943270
95left/right pattern formation (GO:0060972)2.69924768
96postsynaptic membrane organization (GO:0001941)2.69266846
97determination of bilateral symmetry (GO:0009855)2.69131506
98detection of light stimulus involved in sensory perception (GO:0050962)2.68495547
99detection of light stimulus involved in visual perception (GO:0050908)2.68495547
100spermatid nucleus differentiation (GO:0007289)2.66946963
101centriole replication (GO:0007099)2.66890892
102DNA packaging (GO:0006323)2.66831428
103UTP metabolic process (GO:0046051)2.65846674
104spinal cord motor neuron differentiation (GO:0021522)2.62441555
105platelet dense granule organization (GO:0060155)2.61559257
106specification of symmetry (GO:0009799)2.61261987
107regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.59472214
108DNA methylation (GO:0006306)2.58995295
109DNA alkylation (GO:0006305)2.58995295
110regulation of rhodopsin mediated signaling pathway (GO:0022400)2.58653649
111regulation of centrosome cycle (GO:0046605)2.58636761
112negative regulation of axon guidance (GO:1902668)2.57947951
113nucleus organization (GO:0006997)2.56741070
114histone exchange (GO:0043486)2.54520588
115mitotic sister chromatid segregation (GO:0000070)2.53699883
116protein localization to chromosome, centromeric region (GO:0071459)2.53144732
117G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52746385
118nuclear pore organization (GO:0006999)2.51884007
119gene silencing (GO:0016458)2.50455294
120nephron epithelium morphogenesis (GO:0072088)2.49128524
121nephron tubule morphogenesis (GO:0072078)2.49128524
122neuronal action potential (GO:0019228)2.48146877
123histone H2A acetylation (GO:0043968)2.47369015
124limb development (GO:0060173)2.46724765
125appendage development (GO:0048736)2.46724765
126behavioral response to ethanol (GO:0048149)2.46144199
127rhodopsin mediated signaling pathway (GO:0016056)2.46001315
128cellular ketone body metabolic process (GO:0046950)2.45227136
129mitotic sister chromatid cohesion (GO:0007064)2.44946173
130ketone body metabolic process (GO:1902224)2.44627130
131protein refolding (GO:0042026)2.43411878
132lung epithelium development (GO:0060428)2.43260618
133positive regulation of chromosome segregation (GO:0051984)2.42907128
134photoreceptor cell development (GO:0042461)2.42725156
135regulation of collateral sprouting (GO:0048670)2.41983432
136positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.41326091
137detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.38998408
138spindle assembly involved in mitosis (GO:0090307)2.38562625
139organic cation transport (GO:0015695)2.36665602
140regulation of hippo signaling (GO:0035330)2.36647814
141gamma-aminobutyric acid transport (GO:0015812)2.35593194
142intra-S DNA damage checkpoint (GO:0031573)2.35481955
143regulation of histone H3-K9 methylation (GO:0051570)2.34196323
144transmission of nerve impulse (GO:0019226)2.33096405
145cell proliferation in forebrain (GO:0021846)2.33002553
146retinal rod cell development (GO:0046548)2.29582092
147regulation of action potential (GO:0098900)2.26422094
148preassembly of GPI anchor in ER membrane (GO:0016254)2.26288947
149auditory behavior (GO:0031223)2.25284270
150negative regulation of transcription regulatory region DNA binding (GO:2000678)2.24239528
151regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.24161970
152otic vesicle formation (GO:0030916)2.23105167
153negative regulation of T cell differentiation in thymus (GO:0033085)2.22596960
154presynaptic membrane assembly (GO:0097105)2.21119640
155serotonin metabolic process (GO:0042428)2.20359777
156mitochondrial respiratory chain complex I assembly (GO:0032981)2.20247031
157NADH dehydrogenase complex assembly (GO:0010257)2.20247031
158mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.20247031
159lateral ventricle development (GO:0021670)2.19911406
160establishment of planar polarity (GO:0001736)2.19795166
161establishment of tissue polarity (GO:0007164)2.19795166
162regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.19399478
163vitamin transmembrane transport (GO:0035461)2.19165433
164inner ear receptor stereocilium organization (GO:0060122)2.18709834
165primary amino compound metabolic process (GO:1901160)2.17791135
166eye photoreceptor cell development (GO:0042462)2.17580745
167negative regulation of telomere maintenance (GO:0032205)2.16606151
168negative regulation of synaptic transmission, GABAergic (GO:0032229)2.16390794
169indolalkylamine metabolic process (GO:0006586)2.16233409
170one-carbon compound transport (GO:0019755)2.15550010
171retina layer formation (GO:0010842)2.13982071
172telencephalon development (GO:0021537)2.13654191
173dorsal/ventral pattern formation (GO:0009953)2.12821317
174cell differentiation in spinal cord (GO:0021515)2.12176106
175pyrimidine nucleobase catabolic process (GO:0006208)2.11928242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.07001285
2EZH2_22144423_ChIP-Seq_EOC_Human4.87274725
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.77893461
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50959219
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.36275103
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32201772
7NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.31918611
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25562208
9GATA1_26923725_Chip-Seq_HPCs_Mouse2.17438701
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.09031107
11PIAS1_25552417_ChIP-Seq_VCAP_Human2.03552858
12FOXM1_23109430_ChIP-Seq_U2OS_Human1.98885830
13POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91808225
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.89243486
15P300_19829295_ChIP-Seq_ESCs_Human1.83215116
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81796557
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81775642
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.78437727
19IGF1R_20145208_ChIP-Seq_DFB_Human1.78403397
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77454330
21TAF15_26573619_Chip-Seq_HEK293_Human1.76523104
22SMAD4_21799915_ChIP-Seq_A2780_Human1.76088381
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69652092
24E2F7_22180533_ChIP-Seq_HELA_Human1.69079517
25EWS_26573619_Chip-Seq_HEK293_Human1.67122432
26NR3C1_21868756_ChIP-Seq_MCF10A_Human1.66803716
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66631655
28VDR_22108803_ChIP-Seq_LS180_Human1.66494605
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.65791627
30REST_21632747_ChIP-Seq_MESCs_Mouse1.65058669
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63769133
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.62076872
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60652907
34DROSHA_22980978_ChIP-Seq_HELA_Human1.60076437
35SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.59825169
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.58388540
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58034582
38BCAT_22108803_ChIP-Seq_LS180_Human1.57418536
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56981845
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.55565134
41CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.55132525
42STAT3_23295773_ChIP-Seq_U87_Human1.53371368
43AR_21572438_ChIP-Seq_LNCaP_Human1.52694777
44ER_23166858_ChIP-Seq_MCF-7_Human1.48597421
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.46403299
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46390981
47AR_25329375_ChIP-Seq_VCAP_Human1.45651142
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.44429880
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.43442886
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43160694
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41864585
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41495969
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40004286
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39997554
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.38985113
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37566750
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.37330337
58TCF4_22108803_ChIP-Seq_LS180_Human1.37223041
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36550346
60SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.36530924
61TCF4_23295773_ChIP-Seq_U87_Human1.35916883
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34298025
63CBP_20019798_ChIP-Seq_JUKART_Human1.34298025
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33863103
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33712769
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33390573
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32895915
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32117351
69TP53_16413492_ChIP-PET_HCT116_Human1.30641214
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30562530
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29102530
72ELK4_26923725_Chip-Seq_MESODERM_Mouse1.29059318
73WDR5_24793694_ChIP-Seq_LNCAP_Human1.28880519
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28811277
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28782696
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27567532
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27311865
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.24961967
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24465242
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24013884
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23377572
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22886465
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22886465
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22886465
85ZNF274_21170338_ChIP-Seq_K562_Hela1.22494330
86RUNX2_22187159_ChIP-Seq_PCA_Human1.21101829
87TP53_18474530_ChIP-ChIP_U2OS_Human1.19644392
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19488982
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.19315692
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17793101
91YY1_21170310_ChIP-Seq_MESCs_Mouse1.17608040
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16779466
93SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16560585
94MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16534614
95MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16528493
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15946108
97CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.15264953
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14906048
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14864533
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14220543
101FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13782854
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11999560
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11820924
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11613713
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.11074607
106NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.11004618
107NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10659777
108TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10541475
109MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10219887
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10014863
111KAP1_22055183_ChIP-Seq_ESCs_Mouse1.09598511
112CJUN_26792858_Chip-Seq_BT549_Human1.09569784
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09167773
114AHR_22903824_ChIP-Seq_MCF-7_Human1.08241687
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08056621
116TP53_22573176_ChIP-Seq_HFKS_Human1.06942386
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06322341
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05855706
119POU5F1_16518401_ChIP-PET_MESCs_Mouse1.05604573
120RNF2_27304074_Chip-Seq_ESCs_Mouse1.05554730
121REST_18959480_ChIP-ChIP_MESCs_Mouse1.05007461
122PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04835426
123RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03235911
124FOXA1_25329375_ChIP-Seq_VCAP_Human1.02829428
125FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02829428
126NANOG_18555785_Chip-Seq_ESCs_Mouse1.02710986
127SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02655255
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02473788
129MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02201295
130TBL1_22424771_ChIP-Seq_293T_Human1.01815328
131NANOG_21062744_ChIP-ChIP_HESCs_Human1.01692649
132IRF1_19129219_ChIP-ChIP_H3396_Human1.01237922
133PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01129797
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00915433
135STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00583611
136GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00499176
137STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00208340
138SOX2_21211035_ChIP-Seq_LN229_Gbm0.99896385
139NANOG_18692474_ChIP-Seq_MESCs_Mouse0.99412472
140STAT3_18555785_ChIP-Seq_MESCs_Mouse0.99220708
141RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99198541
142EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99198541
143RNF2_27304074_Chip-Seq_NSC_Mouse0.98627202
144TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98507752
145TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.98338360
146SOX9_26525672_Chip-Seq_HEART_Mouse0.97479151
147SOX2_19829295_ChIP-Seq_ESCs_Human0.97457712
148NANOG_19829295_ChIP-Seq_ESCs_Human0.97457712
149FUS_26573619_Chip-Seq_HEK293_Human0.96691980
150YY1_22570637_ChIP-Seq_MALME-3M_Human0.95970227
151RARB_27405468_Chip-Seq_BRAIN_Mouse0.95692716
152TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95279912
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95279912
154NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95001535
155GBX2_23144817_ChIP-Seq_PC3_Human0.94977305
156POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.93990285
157SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93318199
158CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.91961048
159SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.91697657
160SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91447962
161TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91201752
162MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90159991
163CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90148946
164KAP1_27257070_Chip-Seq_ESCs_Mouse0.90031918
165POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89084891
166ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87321832
167SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87079188
168JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85282457
169GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.84887738
170NANOG_16518401_ChIP-PET_MESCs_Mouse0.84775617
171TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84535793
172FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83360993
173DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83299787
174CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82888663
175KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81970946
176CTBP1_25329375_ChIP-Seq_LNCAP_Human0.81800838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.19008076
2MP0002653_abnormal_ependyma_morphology4.23023677
3MP0008877_abnormal_DNA_methylation3.91955145
4MP0003698_abnormal_male_reproductive3.45419195
5MP0001929_abnormal_gametogenesis3.29454745
6MP0005171_absent_coat_pigmentation2.99206181
7MP0002210_abnormal_sex_determination2.48657396
8MP0001984_abnormal_olfaction2.47964082
9MP0008875_abnormal_xenobiotic_pharmacok2.30767533
10MP0006072_abnormal_retinal_apoptosis2.27956962
11MP0005551_abnormal_eye_electrophysiolog2.27699074
12MP0008057_abnormal_DNA_replication2.27130456
13MP0010094_abnormal_chromosome_stability2.14613332
14MP0001145_abnormal_male_reproductive2.13976240
15MP0008058_abnormal_DNA_repair2.13517807
16MP0002161_abnormal_fertility/fecundity2.10533287
17MP0000569_abnormal_digit_pigmentation2.09150494
18MP0004133_heterotaxia2.07917086
19MP0004859_abnormal_synaptic_plasticity2.02799083
20MP0003111_abnormal_nucleus_morphology1.97757521
21MP0009046_muscle_twitch1.91725993
22MP0003693_abnormal_embryo_hatching1.90909765
23MP0003880_abnormal_central_pattern1.90120080
24MP0000653_abnormal_sex_gland1.89995762
25MP0005408_hypopigmentation1.79755214
26MP0009780_abnormal_chondrocyte_physiolo1.79700322
27MP0005253_abnormal_eye_physiology1.79058025
28MP0004233_abnormal_muscle_weight1.72760996
29MP0002938_white_spotting1.71030752
30MP0004043_abnormal_pH_regulation1.70926047
31MP0002160_abnormal_reproductive_system1.69166387
32MP0002928_abnormal_bile_duct1.67180991
33MP0004957_abnormal_blastocyst_morpholog1.66097113
34MP0003011_delayed_dark_adaptation1.61247216
35MP0006276_abnormal_autonomic_nervous1.59650182
36MP0004270_analgesia1.58125735
37MP0005623_abnormal_meninges_morphology1.57068873
38MP0000372_irregular_coat_pigmentation1.55556260
39MP0003787_abnormal_imprinting1.51372667
40MP0003077_abnormal_cell_cycle1.50997694
41MP0003890_abnormal_embryonic-extraembry1.45958008
42MP0002837_dystrophic_cardiac_calcinosis1.43762288
43MP0002132_abnormal_respiratory_system1.43692482
44MP0002234_abnormal_pharynx_morphology1.43449284
45MP0000566_synostosis1.42547824
46MP0010386_abnormal_urinary_bladder1.41526762
47MP0003635_abnormal_synaptic_transmissio1.41094265
48MP0006292_abnormal_olfactory_placode1.37668734
49MP0002638_abnormal_pupillary_reflex1.37314927
50MP0003123_paternal_imprinting1.34891358
51MP0002735_abnormal_chemical_nociception1.32053109
52MP0008932_abnormal_embryonic_tissue1.30765507
53MP0004142_abnormal_muscle_tone1.30077842
54MP0003718_maternal_effect1.28352546
55MP0002876_abnormal_thyroid_physiology1.23759794
56MP0000427_abnormal_hair_cycle1.23407090
57MP0002063_abnormal_learning/memory/cond1.22694873
58MP0003937_abnormal_limbs/digits/tail_de1.22288056
59MP0005423_abnormal_somatic_nervous1.21797153
60MP0003646_muscle_fatigue1.21629250
61MP0001970_abnormal_pain_threshold1.17597415
62MP0003950_abnormal_plasma_membrane1.17577103
63MP0002572_abnormal_emotion/affect_behav1.17476098
64MP0003786_premature_aging1.17275835
65MP0003136_yellow_coat_color1.16301378
66MP0003861_abnormal_nervous_system1.15602293
67MP0000383_abnormal_hair_follicle1.14741101
68MP0000778_abnormal_nervous_system1.14288273
69MP0000026_abnormal_inner_ear1.12442869
70MP0003121_genomic_imprinting1.11890772
71MP0001730_embryonic_growth_arrest1.11888951
72MP0005174_abnormal_tail_pigmentation1.10062423
73MP0000049_abnormal_middle_ear1.09549152
74MP0002751_abnormal_autonomic_nervous1.08788103
75MP0000013_abnormal_adipose_tissue1.07967420
76MP0005391_vision/eye_phenotype1.07164148
77MP0005195_abnormal_posterior_eye1.05956662
78MP0008995_early_reproductive_senescence1.05849323
79MP0003195_calcinosis1.05750104
80MP0001501_abnormal_sleep_pattern1.05710756
81MP0002085_abnormal_embryonic_tissue1.04567263
82MP0001968_abnormal_touch/_nociception1.03733034
83MP0002752_abnormal_somatic_nervous1.03447164
84MP0005499_abnormal_olfactory_system1.03398511
85MP0005394_taste/olfaction_phenotype1.03398511
86MP0008007_abnormal_cellular_replicative1.03281045
87MP0002084_abnormal_developmental_patter1.03166900
88MP0002064_seizures1.02584434
89MP0003283_abnormal_digestive_organ1.01490670
90MP0002882_abnormal_neuron_morphology1.01291911
91MP0002734_abnormal_mechanical_nocicepti1.00810978
92MP0002272_abnormal_nervous_system1.00702802
93MP0009745_abnormal_behavioral_response0.99988828
94MP0005389_reproductive_system_phenotype0.99886284
95MP0002822_catalepsy0.99428687
96MP0002152_abnormal_brain_morphology0.99315627
97MP0002095_abnormal_skin_pigmentation0.94746619
98MP0005084_abnormal_gallbladder_morpholo0.94379234
99MP0001486_abnormal_startle_reflex0.94318960
100MP0002229_neurodegeneration0.93752981
101MP0009250_abnormal_appendicular_skeleto0.93116201
102MP0002733_abnormal_thermal_nociception0.91456513
103MP0005503_abnormal_tendon_morphology0.91402479
104MP0000350_abnormal_cell_proliferation0.91107039
105MP0009384_cardiac_valve_regurgitation0.90507636
106MP0005646_abnormal_pituitary_gland0.89549197
107MP0001440_abnormal_grooming_behavior0.88494391
108MP0001986_abnormal_taste_sensitivity0.87965123
109MP0008872_abnormal_physiological_respon0.87917181
110MP0001529_abnormal_vocalization0.87440794
111MP0002233_abnormal_nose_morphology0.87354801
112MP0001299_abnormal_eye_distance/0.86763140
113MP0008775_abnormal_heart_ventricle0.86736136
114MP0005380_embryogenesis_phenotype0.86194222
115MP0001672_abnormal_embryogenesis/_devel0.86194222
116MP0002184_abnormal_innervation0.86012430
117MP0001697_abnormal_embryo_size0.84591960
118MP0002102_abnormal_ear_morphology0.84554979
119MP0010030_abnormal_orbit_morphology0.83494866
120MP0002736_abnormal_nociception_after0.83379592
121MP0004885_abnormal_endolymph0.83054152
122MP0003755_abnormal_palate_morphology0.82610978
123MP0005645_abnormal_hypothalamus_physiol0.81624175
124MP0001293_anophthalmia0.79769651
125MP0001324_abnormal_eye_pigmentation0.79331329
126MP0004924_abnormal_behavior0.79027136
127MP0005386_behavior/neurological_phenoty0.79027136
128MP0001963_abnormal_hearing_physiology0.78645353
129MP0004811_abnormal_neuron_physiology0.77965745
130MP0001502_abnormal_circadian_rhythm0.77671648
131MP0003119_abnormal_digestive_system0.77435459
132MP0000955_abnormal_spinal_cord0.76876561
133MP0002909_abnormal_adrenal_gland0.76560377
134MP0005377_hearing/vestibular/ear_phenot0.76248953
135MP0001188_hyperpigmentation0.75739365
136MP0008789_abnormal_olfactory_epithelium0.73998394
137MP0002557_abnormal_social/conspecific_i0.71325011
138MP0002067_abnormal_sensory_capabilities0.70819847
139MP0000631_abnormal_neuroendocrine_gland0.70538153
140MP0001905_abnormal_dopamine_level0.69991940
141MP0002282_abnormal_trachea_morphology0.68067901
142MP0003699_abnormal_female_reproductive0.67938639
143MP0003879_abnormal_hair_cell0.67689418
144MP0002080_prenatal_lethality0.65457038
145MP0003632_abnormal_nervous_system0.63308572
146MP0001485_abnormal_pinna_reflex0.62546694
147MP0003984_embryonic_growth_retardation0.61902280
148MP0000534_abnormal_ureter_morphology0.61437540
149MP0010307_abnormal_tumor_latency0.61197930

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.52193841
2Absent/shortened dynein arms (HP:0200106)8.15856098
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.15856098
4Abnormal respiratory motile cilium physiology (HP:0012261)7.74744334
5Abnormal respiratory epithelium morphology (HP:0012253)6.96696996
6Abnormal respiratory motile cilium morphology (HP:0005938)6.96696996
7Abnormal ciliary motility (HP:0012262)6.69818394
8Rhinitis (HP:0012384)6.52224931
9Chronic bronchitis (HP:0004469)5.64699282
10Infertility (HP:0000789)4.13448428
11Chronic hepatic failure (HP:0100626)3.72681726
12Nephronophthisis (HP:0000090)3.53015898
13Bronchiectasis (HP:0002110)3.35016389
14Molar tooth sign on MRI (HP:0002419)3.19572973
15Abnormality of midbrain morphology (HP:0002418)3.19572973
16Supernumerary spleens (HP:0009799)3.17516837
17Type II lissencephaly (HP:0007260)3.16575587
18Medial flaring of the eyebrow (HP:0010747)3.04925993
19Pancreatic fibrosis (HP:0100732)3.00016133
20Bony spicule pigmentary retinopathy (HP:0007737)2.99461555
21Male infertility (HP:0003251)2.96995576
22Nasal polyposis (HP:0100582)2.96111806
23Gait imbalance (HP:0002141)2.77761900
24Congenital stationary night blindness (HP:0007642)2.71760461
25Abnormality of the lower motor neuron (HP:0002366)2.71546164
26Congenital primary aphakia (HP:0007707)2.70691091
27Abnormality of the renal medulla (HP:0100957)2.69378817
28Nephrogenic diabetes insipidus (HP:0009806)2.54312412
29Abnormal drinking behavior (HP:0030082)2.52680836
30Polydipsia (HP:0001959)2.52680836
31Abnormality of the renal cortex (HP:0011035)2.50010966
32Impulsivity (HP:0100710)2.44211535
33Dyschromatopsia (HP:0007641)2.43603320
34Bronchitis (HP:0012387)2.42639247
35Cerebellar dysplasia (HP:0007033)2.41095169
36Pancreatic cysts (HP:0001737)2.38546315
37Male pseudohermaphroditism (HP:0000037)2.35422798
38True hermaphroditism (HP:0010459)2.34908817
39Poor coordination (HP:0002370)2.33123033
40Abnormality of the labia minora (HP:0012880)2.32974601
41Tubulointerstitial nephritis (HP:0001970)2.25958465
42Facial cleft (HP:0002006)2.23707351
43Median cleft lip (HP:0000161)2.22351969
44Chronic sinusitis (HP:0011109)2.20789573
45Postaxial foot polydactyly (HP:0001830)2.20605299
46Furrowed tongue (HP:0000221)2.18336629
47Genital tract atresia (HP:0001827)2.16266437
48Abnormality of the nasal mucosa (HP:0000433)2.11069383
49Vaginal atresia (HP:0000148)2.10368463
50Hyperventilation (HP:0002883)2.09003535
51Cystic liver disease (HP:0006706)2.08519100
52Tubular atrophy (HP:0000092)2.07583531
53Oculomotor apraxia (HP:0000657)2.06627654
54Postaxial hand polydactyly (HP:0001162)2.05332663
55Abdominal situs inversus (HP:0003363)2.00829798
56Abnormality of abdominal situs (HP:0011620)2.00829798
57Congenital hepatic fibrosis (HP:0002612)1.96288641
58Ependymoma (HP:0002888)1.90536201
59Recurrent otitis media (HP:0000403)1.85897800
60Polyuria (HP:0000103)1.85623675
61Increased corneal curvature (HP:0100692)1.84972863
62Keratoconus (HP:0000563)1.84972863
63Attenuation of retinal blood vessels (HP:0007843)1.83564477
64Aplasia/Hypoplasia of the tongue (HP:0010295)1.82982572
65Abnormality of macular pigmentation (HP:0008002)1.82275481
66Recurrent corneal erosions (HP:0000495)1.81924314
67Absent speech (HP:0001344)1.81349882
68Bifid tongue (HP:0010297)1.80610154
69Retinal dysplasia (HP:0007973)1.80306302
70Central scotoma (HP:0000603)1.79911156
71Short ribs (HP:0000773)1.79112225
72Pendular nystagmus (HP:0012043)1.77821573
73Occipital encephalocele (HP:0002085)1.76606405
74Tubulointerstitial fibrosis (HP:0005576)1.76245925
75Sclerocornea (HP:0000647)1.74455712
76Anophthalmia (HP:0000528)1.72422975
77Narrow forehead (HP:0000341)1.71052277
78Medulloblastoma (HP:0002885)1.70015416
79Choroideremia (HP:0001139)1.69935556
80Scotoma (HP:0000575)1.69852978
81Type II diabetes mellitus (HP:0005978)1.68497512
82Preaxial hand polydactyly (HP:0001177)1.68448413
83Hypoplasia of the capital femoral epiphysis (HP:0003090)1.66941825
84Aplasia/Hypoplasia of the lens (HP:0008063)1.66699930
85Abnormal rod and cone electroretinograms (HP:0008323)1.66616443
86Abnormality of the astrocytes (HP:0100707)1.64398441
87Astrocytoma (HP:0009592)1.64398441
88Abnormal biliary tract physiology (HP:0012439)1.64312862
89Bile duct proliferation (HP:0001408)1.64312862
90Delayed gross motor development (HP:0002194)1.63170420
91Retinitis pigmentosa (HP:0000510)1.63030697
92Inability to walk (HP:0002540)1.62537071
93Abnormality of dentin (HP:0010299)1.61520138
94Lissencephaly (HP:0001339)1.61408311
95Oligodactyly (hands) (HP:0001180)1.59660337
96Hemiparesis (HP:0001269)1.58426144
97Decreased central vision (HP:0007663)1.58271724
98Specific learning disability (HP:0001328)1.57830750
99Sloping forehead (HP:0000340)1.57696739
100Neoplasm of the oral cavity (HP:0100649)1.57644801
101Recurrent sinusitis (HP:0011108)1.57191246
102Amyotrophic lateral sclerosis (HP:0007354)1.57171641
103Left ventricular hypertrophy (HP:0001712)1.56441721
104Broad distal phalanx of finger (HP:0009836)1.56095978
105Broad-based gait (HP:0002136)1.56075533
106EEG with generalized epileptiform discharges (HP:0011198)1.55856730
107Constricted visual fields (HP:0001133)1.55613280
108Progressive cerebellar ataxia (HP:0002073)1.53956371
109Hypsarrhythmia (HP:0002521)1.53005301
110Stage 5 chronic kidney disease (HP:0003774)1.52867255
111Prominent nasal bridge (HP:0000426)1.52765351
112Genetic anticipation (HP:0003743)1.52634128
113Spinal muscular atrophy (HP:0007269)1.51818249
114Epileptiform EEG discharges (HP:0011182)1.51539150
115Gaze-evoked nystagmus (HP:0000640)1.51392619
116Astigmatism (HP:0000483)1.51390931
117Hypoplasia of the fovea (HP:0007750)1.51387128
118Aplasia/Hypoplasia of the fovea (HP:0008060)1.51387128
119Tubulointerstitial abnormality (HP:0001969)1.50950533
120Degeneration of anterior horn cells (HP:0002398)1.50730921
121Abnormality of the anterior horn cell (HP:0006802)1.50730921
122Decreased circulating renin level (HP:0003351)1.50044789
123Concave nail (HP:0001598)1.50010438
124Anencephaly (HP:0002323)1.49094400
125Aplasia/hypoplasia of the humerus (HP:0006507)1.48865998
126Congenital sensorineural hearing impairment (HP:0008527)1.48840223
127Congenital, generalized hypertrichosis (HP:0004540)1.48360154
128Broad foot (HP:0001769)1.48100886
129Disproportionate short-trunk short stature (HP:0003521)1.46894635
130Aplasia/Hypoplasia of the tibia (HP:0005772)1.46843538
131Dandy-Walker malformation (HP:0001305)1.46629966
132Selective tooth agenesis (HP:0001592)1.45997832
133Short humerus (HP:0005792)1.45878693
134Heterotopia (HP:0002282)1.45429528
135Abnormality of the dental root (HP:0006486)1.45371526
136Taurodontia (HP:0000679)1.45371526
137Abnormality of permanent molar morphology (HP:0011071)1.45371526
138Severe muscular hypotonia (HP:0006829)1.45341964
139Highly arched eyebrow (HP:0002553)1.45263547
140Fibular hypoplasia (HP:0003038)1.43021162
141Abolished electroretinogram (ERG) (HP:0000550)1.42724730
142Aganglionic megacolon (HP:0002251)1.41375974
143Severe visual impairment (HP:0001141)1.41167188
144Absent rod-and cone-mediated responses on ERG (HP:0007688)1.41106587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.49545378
2PDK45.49545378
3FRK4.39672482
4PNCK4.32927453
5PDK23.55101254
6TESK13.03779603
7ICK2.73556852
8BMPR1B2.51372114
9PRKD32.50175696
10WEE12.43868476
11MAP4K22.40414936
12MAP3K92.25637942
13ADRBK22.21892913
14AKT32.19174761
15TTK2.14350344
16NEK22.05173293
17BRAF1.72701134
18NTRK31.68817004
19MAPK131.66966891
20BUB11.62809067
21INSRR1.58863027
22CDK121.54279614
23PRPF4B1.52881469
24TLK11.47676454
25EPHA41.46052024
26CHEK21.41810103
27TAOK31.40524116
28NEK11.37272629
29PLK11.32635837
30STK381.31976461
31EPHA21.31523956
32ARAF1.29933896
33MAPK151.29440929
34MARK11.19175070
35PTK2B1.18695357
36CDC71.17182411
37PLK41.16149886
38PAK31.14859371
39ERBB31.14818348
40TYRO31.12812399
41ACVR1B1.12305735
42MAP3K41.11927924
43MET1.11769720
44ADRBK11.10669436
45EPHB21.10651473
46LMTK21.08011077
47FLT31.06755041
48MAP3K121.06728412
49ZAK1.03882182
50LATS10.99877777
51SIK20.99781894
52NUAK10.99700311
53PLK30.99613150
54KSR10.98759961
55PRKCE0.98679635
56TGFBR10.96253773
57NTRK20.95811291
58PHKG10.95448731
59PHKG20.95448731
60BRSK20.91987133
61TSSK60.90146354
62MST40.89434485
63CHEK10.88330536
64GRK10.86889644
65AURKA0.85379658
66PASK0.85095291
67LIMK10.84696021
68DYRK30.84198498
69PAK60.84030049
70MUSK0.83672343
71PLK20.83335286
72WNK40.81960487
73CCNB10.81877423
74WNK30.81378705
75EPHA30.80130421
76STK390.78015155
77STK38L0.77746510
78CAMKK20.77185812
79DAPK10.74848797
80DYRK20.74548604
81BCR0.73961158
82CSNK1G20.70578914
83ERBB40.69858679
84TESK20.69329402
85STK160.69320708
86ATR0.69260640
87PRKCG0.67642050
88BCKDK0.66932284
89CDK80.66891015
90MYLK0.66749791
91DYRK1B0.65508417
92TNIK0.65463681
93LATS20.64200326
94CSNK1A1L0.63886758
95MINK10.63763199
96PINK10.63242647
97CDK180.62937685
98CSNK1G10.61452433
99MKNK20.60860837
100NTRK10.60417170
101PRKCI0.60072982
102CASK0.59819824
103PKN10.59546485
104MAP3K70.59040735
105TRIM280.59007241
106GSK3A0.58856059
107CDK150.57952734
108MST1R0.57170255
109ATM0.56985955
110CSNK1G30.54371733
111CDK140.53340897
112CSNK1E0.51595567
113SRPK10.50876693
114CDK20.50775060
115PAK10.50048164
116MAP3K60.49808167
117CSNK1A10.49142366
118CDK11A0.48662843
119CAMKK10.47012119
120CDK10.46740397
121CDK70.46715822
122TAOK20.46567557
123NME10.45772736
124SIK30.44877217
125MAP2K60.44829999
126BRSK10.44499337
127PRKACA0.44188221
128ROCK10.43175711
129ITK0.42739675
130PRKCZ0.42570272
131AURKB0.41960924
132MAP2K70.41547382
133WNK10.41529379
134OXSR10.41226609
135MAPK100.40388928
136VRK10.40050825
137NEK60.39701171
138PTK20.39321544
139SGK2230.39039538
140SGK4940.39039538
141FGFR20.38856718
142PIK3CA0.38493656
143SGK20.38112783
144MTOR0.37157905
145CAMK2D0.36603671
146PRKG10.36450681
147DAPK20.36021063
148GSK3B0.35952082
149PAK40.35752745
150CDK50.35721925
151EIF2AK10.34523340
152CDK30.34143727
153DYRK1A0.33285179
154PRKAA10.32919693
155CAMK2A0.32566411
156UHMK10.32152961
157MAPKAPK30.31986248
158KSR20.31066487
159CAMK2B0.29577248
160RPS6KB20.26911014
161STK30.26595224
162PRKDC0.26404270

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.50734556
2Vitamin B6 metabolism_Homo sapiens_hsa007502.69642606
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.55224512
4Basal transcription factors_Homo sapiens_hsa030222.49671065
5Fanconi anemia pathway_Homo sapiens_hsa034602.41750503
6RNA transport_Homo sapiens_hsa030132.39307730
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31482727
8Oocyte meiosis_Homo sapiens_hsa041142.30659758
9Olfactory transduction_Homo sapiens_hsa047402.18710041
10Synaptic vesicle cycle_Homo sapiens_hsa047212.17292696
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.16653339
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.16218916
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.12263328
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.11436054
15Oxidative phosphorylation_Homo sapiens_hsa001902.00485848
16Nicotine addiction_Homo sapiens_hsa050331.87917286
17Mismatch repair_Homo sapiens_hsa034301.83106703
18mRNA surveillance pathway_Homo sapiens_hsa030151.80591243
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78106477
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.76669083
21Amphetamine addiction_Homo sapiens_hsa050311.74151026
22Butanoate metabolism_Homo sapiens_hsa006501.73567454
23Protein export_Homo sapiens_hsa030601.73542684
24Chemical carcinogenesis_Homo sapiens_hsa052041.71307730
25Homologous recombination_Homo sapiens_hsa034401.68347576
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67928325
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.67178728
28Cell cycle_Homo sapiens_hsa041101.59395956
29Nitrogen metabolism_Homo sapiens_hsa009101.58406252
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.57120104
31Huntingtons disease_Homo sapiens_hsa050161.50707939
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50336093
33Collecting duct acid secretion_Homo sapiens_hsa049661.50201114
34Spliceosome_Homo sapiens_hsa030401.47961976
35Long-term potentiation_Homo sapiens_hsa047201.47319121
36Parkinsons disease_Homo sapiens_hsa050121.45810386
37beta-Alanine metabolism_Homo sapiens_hsa004101.43806720
38Nucleotide excision repair_Homo sapiens_hsa034201.41178154
39Hedgehog signaling pathway_Homo sapiens_hsa043401.41060997
40Proteasome_Homo sapiens_hsa030501.38101053
41Selenocompound metabolism_Homo sapiens_hsa004501.36981905
42Glutamatergic synapse_Homo sapiens_hsa047241.35818228
43Circadian entrainment_Homo sapiens_hsa047131.34830401
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34480929
45Purine metabolism_Homo sapiens_hsa002301.34416007
46RNA polymerase_Homo sapiens_hsa030201.33364750
47Histidine metabolism_Homo sapiens_hsa003401.28862183
48Pyruvate metabolism_Homo sapiens_hsa006201.28615503
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.25614806
50DNA replication_Homo sapiens_hsa030301.25013802
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23374882
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22861621
53RNA degradation_Homo sapiens_hsa030181.19978311
54Caffeine metabolism_Homo sapiens_hsa002321.18841694
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.14742966
56Fructose and mannose metabolism_Homo sapiens_hsa000511.14468970
57ABC transporters_Homo sapiens_hsa020101.14012104
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13855793
59Base excision repair_Homo sapiens_hsa034101.12607314
60Cardiac muscle contraction_Homo sapiens_hsa042601.12111298
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11986919
62Alzheimers disease_Homo sapiens_hsa050101.11739141
63Tryptophan metabolism_Homo sapiens_hsa003801.10624500
64Dopaminergic synapse_Homo sapiens_hsa047281.10135565
65Dorso-ventral axis formation_Homo sapiens_hsa043201.09184593
66Glucagon signaling pathway_Homo sapiens_hsa049221.09059515
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08765548
68Fatty acid biosynthesis_Homo sapiens_hsa000611.06379945
69Insulin secretion_Homo sapiens_hsa049111.06208826
70GABAergic synapse_Homo sapiens_hsa047271.06149075
71Non-homologous end-joining_Homo sapiens_hsa034501.01220232
72Tyrosine metabolism_Homo sapiens_hsa003501.00926129
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.98266303
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97986411
75Basal cell carcinoma_Homo sapiens_hsa052170.96651924
76Morphine addiction_Homo sapiens_hsa050320.95763010
77Hippo signaling pathway_Homo sapiens_hsa043900.94773702
78Pyrimidine metabolism_Homo sapiens_hsa002400.93280551
79Taste transduction_Homo sapiens_hsa047420.91518072
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90438444
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90316468
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.87469425
83Cocaine addiction_Homo sapiens_hsa050300.87204564
84Peroxisome_Homo sapiens_hsa041460.85576221
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84520580
86Retinol metabolism_Homo sapiens_hsa008300.81605569
87Regulation of autophagy_Homo sapiens_hsa041400.79940862
88Alcoholism_Homo sapiens_hsa050340.79768676
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79707675
90Ovarian steroidogenesis_Homo sapiens_hsa049130.79429388
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.79216086
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78317850
93Calcium signaling pathway_Homo sapiens_hsa040200.77613846
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77138301
95Circadian rhythm_Homo sapiens_hsa047100.76850962
96Propanoate metabolism_Homo sapiens_hsa006400.75824629
97Estrogen signaling pathway_Homo sapiens_hsa049150.75657630
98Oxytocin signaling pathway_Homo sapiens_hsa049210.75063645
99Salivary secretion_Homo sapiens_hsa049700.74279107
100Linoleic acid metabolism_Homo sapiens_hsa005910.73650549
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72943217
102Tight junction_Homo sapiens_hsa045300.72768185
103Biosynthesis of amino acids_Homo sapiens_hsa012300.72315980
104Arachidonic acid metabolism_Homo sapiens_hsa005900.70841442
105Renin secretion_Homo sapiens_hsa049240.70768723
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70688551
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70249428
108Wnt signaling pathway_Homo sapiens_hsa043100.69319588
109Glutathione metabolism_Homo sapiens_hsa004800.69231366
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68666682
111Serotonergic synapse_Homo sapiens_hsa047260.68037059
112Gap junction_Homo sapiens_hsa045400.68013298
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67753143
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64845975
115Sphingolipid metabolism_Homo sapiens_hsa006000.64149862
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63730983
117Steroid biosynthesis_Homo sapiens_hsa001000.63650546
118Metabolic pathways_Homo sapiens_hsa011000.62701122
119cAMP signaling pathway_Homo sapiens_hsa040240.62008575
120Gastric acid secretion_Homo sapiens_hsa049710.61620236
121Phenylalanine metabolism_Homo sapiens_hsa003600.61406232
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61335804
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61008038
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60562320
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58342297
126Mineral absorption_Homo sapiens_hsa049780.58295938
127TGF-beta signaling pathway_Homo sapiens_hsa043500.58172528
128Vibrio cholerae infection_Homo sapiens_hsa051100.57893819
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56879176
130Inositol phosphate metabolism_Homo sapiens_hsa005620.56792068
131mTOR signaling pathway_Homo sapiens_hsa041500.56311725
132Pentose phosphate pathway_Homo sapiens_hsa000300.52738345
133Axon guidance_Homo sapiens_hsa043600.52369964
134p53 signaling pathway_Homo sapiens_hsa041150.51544183
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.51153972
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.50204005
137Cholinergic synapse_Homo sapiens_hsa047250.50168588
138Long-term depression_Homo sapiens_hsa047300.48320704
139ECM-receptor interaction_Homo sapiens_hsa045120.47855557
140Carbon metabolism_Homo sapiens_hsa012000.47152895
141Glycerolipid metabolism_Homo sapiens_hsa005610.47038463
142Dilated cardiomyopathy_Homo sapiens_hsa054140.45691289
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45185640
144Ether lipid metabolism_Homo sapiens_hsa005650.43820440
145ErbB signaling pathway_Homo sapiens_hsa040120.43450558
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.42964622
147Melanogenesis_Homo sapiens_hsa049160.41597832
148Epstein-Barr virus infection_Homo sapiens_hsa051690.41159908
149Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41151270
150Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40930068
151GnRH signaling pathway_Homo sapiens_hsa049120.40733621
152Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40365849
153Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39710526

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