MON1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid metabolic process (GO:0046655)5.49105850
2vitamin transmembrane transport (GO:0035461)5.15160429
3protein maturation by protein folding (GO:0022417)5.06018972
4folic acid transport (GO:0015884)4.97417000
5NADH metabolic process (GO:0006734)4.91571224
6purine nucleobase biosynthetic process (GO:0009113)4.77920233
7DNA deamination (GO:0045006)4.62304620
8proline biosynthetic process (GO:0006561)4.50609379
9pantothenate metabolic process (GO:0015939)4.46941042
10glycine metabolic process (GO:0006544)4.21776267
11cell migration in hindbrain (GO:0021535)4.13641829
12modified amino acid transport (GO:0072337)4.13112311
13serine family amino acid catabolic process (GO:0009071)4.13014463
14UDP-N-acetylglucosamine metabolic process (GO:0006047)4.12639085
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.11513022
16layer formation in cerebral cortex (GO:0021819)3.98982780
17nuclear envelope reassembly (GO:0031468)3.97220057
18mitotic nuclear envelope reassembly (GO:0007084)3.97220057
19CDP-diacylglycerol metabolic process (GO:0046341)3.93555761
20chaperone-mediated protein transport (GO:0072321)3.90729694
21protein insertion into membrane (GO:0051205)3.89301925
22biotin metabolic process (GO:0006768)3.87206001
23mitochondrial fusion (GO:0008053)3.86924790
24negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.85176955
25nucleobase biosynthetic process (GO:0046112)3.82364244
26GDP-mannose metabolic process (GO:0019673)3.75419735
27establishment of mitochondrion localization (GO:0051654)3.74380137
28regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.72049174
29amino acid salvage (GO:0043102)3.70627741
30L-methionine salvage (GO:0071267)3.70627741
31L-methionine biosynthetic process (GO:0071265)3.70627741
32S-adenosylmethionine metabolic process (GO:0046500)3.63097244
33iron-sulfur cluster assembly (GO:0016226)3.62697290
34metallo-sulfur cluster assembly (GO:0031163)3.62697290
35peptidyl-arginine omega-N-methylation (GO:0035247)3.60231370
36vitamin transport (GO:0051180)3.47731914
37serine family amino acid metabolic process (GO:0009069)3.46961958
38ribosome assembly (GO:0042255)3.46780214
39synaptic vesicle exocytosis (GO:0016079)3.43565529
40Golgi transport vesicle coating (GO:0048200)3.40102905
41COPI coating of Golgi vesicle (GO:0048205)3.40102905
42mitochondrion transport along microtubule (GO:0047497)3.38519796
43establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.38519796
44response to misfolded protein (GO:0051788)3.37681868
45tRNA methylation (GO:0030488)3.37482970
46antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.36331870
47antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36331870
48cofactor transport (GO:0051181)3.31715760
49autophagic vacuole assembly (GO:0000045)3.29425197
50regulation of short-term neuronal synaptic plasticity (GO:0048172)3.27453575
51proteasome assembly (GO:0043248)3.26283873
52protein retention in ER lumen (GO:0006621)3.22317513
53serine family amino acid biosynthetic process (GO:0009070)3.22135253
54sulfur amino acid catabolic process (GO:0000098)3.20832531
55intestinal cholesterol absorption (GO:0030299)3.20568077
56glutamate secretion (GO:0014047)3.20485815
57cysteine metabolic process (GO:0006534)3.20356835
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.20336580
59termination of RNA polymerase III transcription (GO:0006386)3.20336580
60pyrimidine-containing compound transmembrane transport (GO:0072531)3.17731611
61nucleotide-sugar biosynthetic process (GO:0009226)3.13741306
62GMP metabolic process (GO:0046037)3.13448791
63cellular metabolic compound salvage (GO:0043094)3.11921084
64amino-acid betaine metabolic process (GO:0006577)3.11397527
65establishment of protein localization to mitochondrion (GO:0072655)3.10695032
66sulfur amino acid biosynthetic process (GO:0000097)3.10427986
67positive regulation of synapse maturation (GO:0090129)3.07701702
68nucleobase-containing small molecule interconversion (GO:0015949)3.07353756
69establishment of protein localization to mitochondrial membrane (GO:0090151)3.06168027
70protein targeting to mitochondrion (GO:0006626)3.05097794
71proline metabolic process (GO:0006560)3.03142853
72methionine metabolic process (GO:0006555)2.99762574
73positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.99148366
74retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.97391881
75L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97355242
76synaptic vesicle docking involved in exocytosis (GO:0016081)2.97119313
77guanosine-containing compound biosynthetic process (GO:1901070)2.95855914
78histone arginine methylation (GO:0034969)2.95841916
79mitochondrion degradation (GO:0000422)2.95505343
80CDP-diacylglycerol biosynthetic process (GO:0016024)2.95265969
81de novo posttranslational protein folding (GO:0051084)2.92642660
82peptidyl-arginine N-methylation (GO:0035246)2.92600712
83peptidyl-arginine methylation (GO:0018216)2.92600712
84urate metabolic process (GO:0046415)2.92084287
85CTP metabolic process (GO:0046036)2.90739536
86CTP biosynthetic process (GO:0006241)2.90739536
87pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.90397278
88sulfur amino acid metabolic process (GO:0000096)2.90380574
89regulation of cellular respiration (GO:0043457)2.89652531
90rRNA transcription (GO:0009303)2.88506839
91L-phenylalanine metabolic process (GO:0006558)2.88362705
92erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.88362705
93N-acetylneuraminate metabolic process (GO:0006054)2.87630208
94triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.86795829
95intestinal absorption (GO:0050892)2.86659252
96barbed-end actin filament capping (GO:0051016)2.84782661
97pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.82840665
982-oxoglutarate metabolic process (GO:0006103)2.82469698
99rRNA modification (GO:0000154)2.82303012
100heme transport (GO:0015886)2.82012407
101positive regulation of mitochondrion organization (GO:0010822)2.81555761
102negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.80419857
103polyamine biosynthetic process (GO:0006596)2.80413078
104synaptic vesicle endocytosis (GO:0048488)2.79786502
105de novo protein folding (GO:0006458)2.78831576
106L-phenylalanine catabolic process (GO:0006559)2.78484830
107erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.78484830
108methionine biosynthetic process (GO:0009086)2.78354195
109antigen processing and presentation via MHC class Ib (GO:0002475)2.78329075
110misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.77058373
111protein localization to mitochondrion (GO:0070585)2.76577287
112ubiquinone biosynthetic process (GO:0006744)2.75920207
113lipopolysaccharide biosynthetic process (GO:0009103)2.75799134
114fructose metabolic process (GO:0006000)2.75727228
115pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.75649318
116positive regulation of pseudopodium assembly (GO:0031274)2.75617098
117ribosome biogenesis (GO:0042254)2.75291381
118peptidyl-histidine modification (GO:0018202)2.75131281
119positive regulation of protein targeting to membrane (GO:0090314)2.74316439
120regulation of cholesterol homeostasis (GO:2000188)2.73981486
121L-serine metabolic process (GO:0006563)2.72010769
122positive regulation of triglyceride lipase activity (GO:0061365)2.71616693
123positive regulation of lipoprotein lipase activity (GO:0051006)2.71616693
124purine nucleotide salvage (GO:0032261)2.70828858
125maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.70473844
126intracellular estrogen receptor signaling pathway (GO:0030520)2.69774836
127regulation of mitochondrial translation (GO:0070129)2.66955117
128regulation of cellular amino acid metabolic process (GO:0006521)2.66087784
129pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.65503629
130mitochondrial respiratory chain complex assembly (GO:0033108)2.64944536
131galactose catabolic process (GO:0019388)2.64444209
132antigen processing and presentation of endogenous antigen (GO:0019883)2.63690404
133positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.62042194
134UTP biosynthetic process (GO:0006228)2.61697001
135protein complex biogenesis (GO:0070271)2.61291532
136regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.61102335
137mitochondrial calcium ion transport (GO:0006851)2.60870047
138positive regulation of protein sumoylation (GO:0033235)2.60825517
139GTP biosynthetic process (GO:0006183)2.59790177
140regulation of protein targeting to membrane (GO:0090313)2.59537571
141positive regulation of protein depolymerization (GO:1901881)2.59166976
142purine nucleobase metabolic process (GO:0006144)2.58335247
143positive regulation of triglyceride metabolic process (GO:0090208)2.57505625
144mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.57043831
145nucleoside salvage (GO:0043174)2.56155696
146deoxyribose phosphate biosynthetic process (GO:0046385)2.55983860
1472-deoxyribonucleotide biosynthetic process (GO:0009265)2.55983860
148dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.55422804
149negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55297481
150nucleotide-sugar metabolic process (GO:0009225)2.55266452
151positive regulation of Cdc42 GTPase activity (GO:0043089)2.54877518
152regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.54733098
153chaperone mediated protein folding requiring cofactor (GO:0051085)2.54723954
154heart contraction (GO:0060047)2.52765661
155heart process (GO:0003015)2.52765661
156regulation of mitochondrion organization (GO:0010821)2.51999203
157regulation of triglyceride catabolic process (GO:0010896)2.51681435
158water-soluble vitamin metabolic process (GO:0006767)2.51423550
159positive regulation of triglyceride biosynthetic process (GO:0010867)2.51009935
160anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.50392759
161regulation of cholesterol esterification (GO:0010872)2.49215687
162pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.48763942
163regulation of protein heterodimerization activity (GO:0043497)2.47408567
164L-serine transport (GO:0015825)2.47253628
165regulation of translation in response to stress (GO:0043555)2.46149425
166regulation of pseudopodium assembly (GO:0031272)2.46037859
167positive regulation of mitochondrial fission (GO:0090141)2.44599066
168alpha-linolenic acid metabolic process (GO:0036109)2.44578945
169UV protection (GO:0009650)2.44051963
170response to gravity (GO:0009629)2.43267191
171folic acid-containing compound metabolic process (GO:0006760)2.43139584
172ubiquinone metabolic process (GO:0006743)2.43092755
173drug transport (GO:0015893)2.42530795
174serine transport (GO:0032329)2.42486101
175positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.41075911
176NADH dehydrogenase complex assembly (GO:0010257)2.40128316
177mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.40128316
178mitochondrial respiratory chain complex I assembly (GO:0032981)2.40128316
179oxidative phosphorylation (GO:0006119)2.40044800
180valine metabolic process (GO:0006573)2.39927619
181positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.39091068
182negative regulation of microtubule polymerization (GO:0031115)2.38962275
183energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.38938049
184ATP hydrolysis coupled proton transport (GO:0015991)2.38938049
185tRNA modification (GO:0006400)2.38649866
186aromatic amino acid family metabolic process (GO:0009072)2.38509006
187establishment of viral latency (GO:0019043)2.37832620
188high-density lipoprotein particle remodeling (GO:0034375)2.34186652
189bile acid and bile salt transport (GO:0015721)2.33570636
190mannose metabolic process (GO:0006013)2.33235685
191carnitine metabolic process (GO:0009437)2.33152954
192negative regulation of ligase activity (GO:0051352)2.32388760
193negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.32388760
194positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.32368588
195intestinal epithelial cell development (GO:0060576)2.29873056
196rRNA methylation (GO:0031167)2.29529003

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.59003078
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.31841145
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01793097
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90353690
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.79968180
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71871115
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.64212264
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63064076
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.56752130
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48730154
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.37830573
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.23781008
13* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.20637743
14ZNF263_19887448_ChIP-Seq_K562_Human2.19343953
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19335484
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13369850
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11706166
18CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.07650078
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01041401
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.97871092
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.95934547
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.92131743
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85654975
24MYC_22102868_ChIP-Seq_BL_Human1.83389539
25GABP_19822575_ChIP-Seq_HepG2_Human1.80303814
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74571038
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.72902284
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.72661653
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.70590190
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.70122365
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70081745
32VDR_23849224_ChIP-Seq_CD4+_Human1.69490507
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60526509
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57974131
35XRN2_22483619_ChIP-Seq_HELA_Human1.56552182
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54453638
37SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53643097
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52281136
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52042644
40* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50398967
41CIITA_25753668_ChIP-Seq_RAJI_Human1.47658144
42FOXP3_21729870_ChIP-Seq_TREG_Human1.46556368
43LXR_22158963_ChIP-Seq_LIVER_Mouse1.44412427
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43978714
45SA1_27219007_Chip-Seq_ERYTHROID_Human1.42400745
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42025528
47DCP1A_22483619_ChIP-Seq_HELA_Human1.41917713
48UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39875967
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39826834
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.39414488
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39040046
52SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.38455068
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38214655
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37220067
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.36825953
56VDR_21846776_ChIP-Seq_THP-1_Human1.36392819
57* SRF_21415370_ChIP-Seq_HL-1_Mouse1.35723283
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34465190
59FOXP1_21924763_ChIP-Seq_HESCs_Human1.34283600
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33067797
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32752743
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32403336
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30961192
64TET1_21490601_ChIP-Seq_MESCs_Mouse1.30935939
65TBX5_21415370_ChIP-Seq_HL-1_Mouse1.30429628
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29184407
67BCOR_27268052_Chip-Seq_Bcells_Human1.27773404
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27337321
69SMC4_20622854_ChIP-Seq_HELA_Human1.26626135
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26365678
71CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.25761367
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25520217
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25290930
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25247638
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.25097397
76IRF8_22096565_ChIP-ChIP_GC-B_Human1.24440715
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24423984
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24093844
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23978800
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.23890141
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23435263
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23181607
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23028379
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22687789
85SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.21190347
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21124482
87KDM5A_27292631_Chip-Seq_BREAST_Human1.21066001
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21060482
89RARA_24833708_ChIP-Seq_LIVER_Mouse1.20476489
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20306840
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17985068
92P68_20966046_ChIP-Seq_HELA_Human1.17115628
93* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16661826
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16254115
95BCL6_27268052_Chip-Seq_Bcells_Human1.15931527
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15883764
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15128133
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15068212
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14814412
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12482679
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11538374
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11106733
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10495946
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09882749
105RACK7_27058665_Chip-Seq_MCF-7_Human1.09773063
106CTCF_27219007_Chip-Seq_Bcells_Human1.09020569
107ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08947406
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08658262
109CTCF_20526341_ChIP-Seq_ESCs_Human1.08483723
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08199196
111MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07551170
112RARB_24833708_ChIP-Seq_LIVER_Mouse1.07536704
113PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06754082
114ELK3_25401928_ChIP-Seq_HUVEC_Human1.06430191
115* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05814317
116ATF3_27146783_Chip-Seq_COLON_Human1.05405507
117RARB_27405468_Chip-Seq_BRAIN_Mouse1.05191694
118PHF8_20622854_ChIP-Seq_HELA_Human1.05051144
119EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05012448
120LXR_22292898_ChIP-Seq_THP-1_Human1.04986321
121MAF_26560356_Chip-Seq_TH2_Human1.04950202
122TTF2_22483619_ChIP-Seq_HELA_Human1.04834756
123SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04676544
124NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04624296
125* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04404659
126NOTCH1_21737748_ChIP-Seq_TLL_Human1.04207980
127MAF_26560356_Chip-Seq_TH1_Human1.03902024
128SPI1_23547873_ChIP-Seq_NB4_Human1.02837613
129CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01909470
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01458990
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01222487
132* CTCF_26484167_Chip-Seq_Bcells_Mouse1.01054921
133MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00807545
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99923155
135SA1_27219007_Chip-Seq_Bcells_Human0.98332572
136ELF1_20517297_ChIP-Seq_JURKAT_Human0.98055205
137GATA1_22025678_ChIP-Seq_K562_Human0.97873559
138ESR2_21235772_ChIP-Seq_MCF-7_Human0.97729533
139CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97218788
140CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96958891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell5.43833756
2MP0005360_urolithiasis4.45997607
3MP0004859_abnormal_synaptic_plasticity4.33293074
4MP0002139_abnormal_hepatobiliary_system3.76185397
5MP0005365_abnormal_bile_salt3.64533805
6MP0005085_abnormal_gallbladder_physiolo2.97661217
7MP0001666_abnormal_nutrient_absorption2.88969457
8MP0003693_abnormal_embryo_hatching2.83781837
9MP0008260_abnormal_autophagy2.61753081
10MP0003329_amyloid_beta_deposits2.59631351
11MP0008875_abnormal_xenobiotic_pharmacok2.56125871
12MP0004270_analgesia2.54993646
13MP0003191_abnormal_cellular_cholesterol2.52899254
14MP0005423_abnormal_somatic_nervous2.51252538
15MP0000750_abnormal_muscle_regeneration2.49739759
16MP0003635_abnormal_synaptic_transmissio2.39823691
17MP0005623_abnormal_meninges_morphology2.30418836
18MP0003718_maternal_effect2.29348728
19MP0010329_abnormal_lipoprotein_level2.21595658
20MP0003656_abnormal_erythrocyte_physiolo2.19028155
21MP0000751_myopathy2.18331547
22MP0005332_abnormal_amino_acid2.14647862
23MP0005451_abnormal_body_composition2.07312441
24MP0004233_abnormal_muscle_weight2.07048943
25MP0001529_abnormal_vocalization2.00667805
26MP0002064_seizures1.97104245
27MP0006036_abnormal_mitochondrial_physio1.84451938
28MP0000749_muscle_degeneration1.81825076
29MP0004019_abnormal_vitamin_homeostasis1.80446988
30MP0000609_abnormal_liver_physiology1.78384565
31MP0002735_abnormal_chemical_nociception1.74209957
32MP0001905_abnormal_dopamine_level1.73040548
33MP0009333_abnormal_splenocyte_physiolog1.70204062
34MP0005083_abnormal_biliary_tract1.69941667
35MP0003806_abnormal_nucleotide_metabolis1.68509852
36MP0003866_abnormal_defecation1.67724958
37MP0002063_abnormal_learning/memory/cond1.66653176
38MP0009643_abnormal_urine_homeostasis1.64896312
39MP0004858_abnormal_nervous_system1.62983402
40MP0005319_abnormal_enzyme/_coenzyme1.62299992
41MP0004811_abnormal_neuron_physiology1.60910189
42MP0005636_abnormal_mineral_homeostasis1.60388928
43MP0003878_abnormal_ear_physiology1.57162492
44MP0005377_hearing/vestibular/ear_phenot1.57162492
45MP0001764_abnormal_homeostasis1.56800782
46MP0001756_abnormal_urination1.55936337
47MP0002733_abnormal_thermal_nociception1.55366347
48MP0000678_abnormal_parathyroid_gland1.54861224
49MP0010234_abnormal_vibrissa_follicle1.52768555
50MP0002572_abnormal_emotion/affect_behav1.51114445
51MP0009745_abnormal_behavioral_response1.48944896
52MP0004145_abnormal_muscle_electrophysio1.47982605
53MP0002734_abnormal_mechanical_nocicepti1.46836426
54MP0004147_increased_porphyrin_level1.44532324
55MP0002118_abnormal_lipid_homeostasis1.43967697
56MP0002132_abnormal_respiratory_system1.43809802
57MP0009046_muscle_twitch1.43597342
58MP0001968_abnormal_touch/_nociception1.43325373
59MP0002332_abnormal_exercise_endurance1.43104934
60MP0000759_abnormal_skeletal_muscle1.42862890
61MP0003705_abnormal_hypodermis_morpholog1.41993223
62MP0003111_abnormal_nucleus_morphology1.35329737
63MP0004043_abnormal_pH_regulation1.33566055
64MP0000490_abnormal_crypts_of1.32970720
65MP0001545_abnormal_hematopoietic_system1.32508145
66MP0005397_hematopoietic_system_phenotyp1.32508145
67MP0000747_muscle_weakness1.28169662
68MP0006276_abnormal_autonomic_nervous1.28142576
69MP0002396_abnormal_hematopoietic_system1.26122940
70MP0001970_abnormal_pain_threshold1.25761020
71MP0005671_abnormal_response_to1.25487583
72MP0006035_abnormal_mitochondrial_morpho1.25052790
73MP0005670_abnormal_white_adipose1.24820217
74MP0004947_skin_inflammation1.23659875
75MP0005330_cardiomyopathy1.23526197
76MP0008874_decreased_physiological_sensi1.22059131
77MP0000003_abnormal_adipose_tissue1.21791138
78MP0009379_abnormal_foot_pigmentation1.21606977
79MP0003634_abnormal_glial_cell1.21527955
80MP0003763_abnormal_thymus_physiology1.20878274
81MP0000465_gastrointestinal_hemorrhage1.20434539
82MP0001873_stomach_inflammation1.18411264
83MP0008789_abnormal_olfactory_epithelium1.17767660
84MP0000778_abnormal_nervous_system1.16586777
85MP0003724_increased_susceptibility_to1.14791584
86MP0010155_abnormal_intestine_physiology1.14466571
87MP0008469_abnormal_protein_level1.14287809
88MP0003868_abnormal_feces_composition1.12399358
89MP0001661_extended_life_span1.11308968
90MP0005584_abnormal_enzyme/coenzyme_acti1.10891159
91MP0002736_abnormal_nociception_after1.10258574
92MP0002269_muscular_atrophy1.09918133
93MP0008058_abnormal_DNA_repair1.09829858
94MP0003436_decreased_susceptibility_to1.07617509
95MP0005499_abnormal_olfactory_system1.07171118
96MP0005394_taste/olfaction_phenotype1.07171118
97MP0002066_abnormal_motor_capabilities/c1.07048387
98MP0005501_abnormal_skin_physiology1.06843473
99MP0002272_abnormal_nervous_system1.06147451
100MP0003186_abnormal_redox_activity1.03421710
101MP0005464_abnormal_platelet_physiology1.02809522
102MP0000685_abnormal_immune_system1.01896836
103MP0008569_lethality_at_weaning1.00744967
104MP0002822_catalepsy0.99899336
105MP0004957_abnormal_blastocyst_morpholog0.99864225
106MP0008932_abnormal_embryonic_tissue0.99781870
107MP0002876_abnormal_thyroid_physiology0.98651635
108MP0000598_abnormal_liver_morphology0.98645032
109MP0009053_abnormal_anal_canal0.98213074
110MP0003786_premature_aging0.97964210
111MP0001440_abnormal_grooming_behavior0.97963048
112MP0005058_abnormal_lysosome_morphology0.97876736
113MP0003221_abnormal_cardiomyocyte_apopto0.97232932
114MP0009785_altered_susceptibility_to0.95090717
115MP0002796_impaired_skin_barrier0.94213921
116MP0005220_abnormal_exocrine_pancreas0.93287104
117MP0003646_muscle_fatigue0.93184088
118MP0000049_abnormal_middle_ear0.93169529
119MP0002882_abnormal_neuron_morphology0.92830099
120MP0000733_abnormal_muscle_development0.92397156
121MP0010368_abnormal_lymphatic_system0.91930237
122MP0000467_abnormal_esophagus_morphology0.91678616
123MP0000358_abnormal_cell_content/0.90522030
124MP0000689_abnormal_spleen_morphology0.90300056
125MP0005310_abnormal_salivary_gland0.90022907
126MP0005025_abnormal_response_to0.89720867
127MP0002722_abnormal_immune_system0.89647274
128MP0003252_abnormal_bile_duct0.89643357
129MP0003879_abnormal_hair_cell0.89605776
130MP0002166_altered_tumor_susceptibility0.89357104
131MP0004924_abnormal_behavior0.89313445
132MP0005386_behavior/neurological_phenoty0.89313445
133MP0001845_abnormal_inflammatory_respons0.87642367
134MP0009642_abnormal_blood_homeostasis0.87622531
135MP0000681_abnormal_thyroid_gland0.86829779
136MP0004742_abnormal_vestibular_system0.86490804
137MP0004264_abnormal_extraembryonic_tissu0.85575802
138MP0000343_altered_response_to0.85347046
139MP0000955_abnormal_spinal_cord0.85320802
140MP0002398_abnormal_bone_marrow0.84171506
141MP0003123_paternal_imprinting0.83634643
142MP0003137_abnormal_impulse_conducting0.82845318
143MP0002136_abnormal_kidney_physiology0.82330796
144MP0002723_abnormal_immune_serum0.81794399
145MP0009764_decreased_sensitivity_to0.81280624
146MP0000537_abnormal_urethra_morphology0.81227195
147MP0002177_abnormal_outer_ear0.81005192
148MP0000604_amyloidosis0.80077145
149MP0001765_abnormal_ion_homeostasis0.79919389
150MP0005084_abnormal_gallbladder_morpholo0.79527507
151MP0002106_abnormal_muscle_physiology0.79508589
152MP0003941_abnormal_skin_development0.78916837
153MP0003195_calcinosis0.78415153
154MP0000716_abnormal_immune_system0.78323158
155MP0003075_altered_response_to0.78092024
156MP0002067_abnormal_sensory_capabilities0.78019179
157MP0000538_abnormal_urinary_bladder0.77105642
158MP0002429_abnormal_blood_cell0.76120131
159MP0001730_embryonic_growth_arrest0.76102130
160MP0002069_abnormal_eating/drinking_beha0.75951664
161MP0004510_myositis0.74374805
162MP0001727_abnormal_embryo_implantation0.73116896
163MP0000013_abnormal_adipose_tissue0.72565095
164MP0001346_abnormal_lacrimal_gland0.72349465
165MP0005000_abnormal_immune_tolerance0.71233420
166MP0001800_abnormal_humoral_immune0.71124050
167MP0002078_abnormal_glucose_homeostasis0.70339714
168MP0001819_abnormal_immune_cell0.70192146
169MP0008438_abnormal_cutaneous_collagen0.69813991
170MP0005448_abnormal_energy_balance0.69632115
171MP0002152_abnormal_brain_morphology0.69484786
172MP0002420_abnormal_adaptive_immunity0.69280062
173MP0009765_abnormal_xenobiotic_induced0.69141536
174MP0003633_abnormal_nervous_system0.67382891
175MP0004087_abnormal_muscle_fiber0.66988018
176MP0005075_abnormal_melanosome_morpholog0.66827241
177MP0000015_abnormal_ear_pigmentation0.66563030
178MP0002249_abnormal_larynx_morphology0.65596505
179MP0005266_abnormal_metabolism0.64316407

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)4.82140922
2Hyperglycinemia (HP:0002154)4.79366061
3Gout (HP:0001997)4.65853444
4Abnormality of serine family amino acid metabolism (HP:0010894)4.04072976
5Abnormality of glycine metabolism (HP:0010895)4.04072976
6Ragged-red muscle fibers (HP:0003200)3.85573846
7Progressive muscle weakness (HP:0003323)3.69976706
8Abnormality of aromatic amino acid family metabolism (HP:0004338)3.63256020
9Upper limb amyotrophy (HP:0009129)3.60035053
10Distal upper limb amyotrophy (HP:0007149)3.60035053
11Hand muscle atrophy (HP:0009130)3.53668727
12Increased serum pyruvate (HP:0003542)3.52226161
13Abnormality of glycolysis (HP:0004366)3.48436344
14Pustule (HP:0200039)3.36663172
15Myopathic facies (HP:0002058)3.28256860
16Abnormal mitochondria in muscle tissue (HP:0008316)3.27680907
17Myokymia (HP:0002411)3.22355786
18Retinal dysplasia (HP:0007973)3.17935804
19Abnormality of serum amino acid levels (HP:0003112)3.17491244
20Entropion (HP:0000621)3.17445169
21Insomnia (HP:0100785)3.10333323
22Tetraplegia (HP:0002445)3.07936422
23Supranuclear gaze palsy (HP:0000605)3.06105908
24Reduced antithrombin III activity (HP:0001976)3.00658102
25Hyperlipoproteinemia (HP:0010980)2.96898202
26Hypobetalipoproteinemia (HP:0003563)2.90272434
27Abnormality of fatty-acid metabolism (HP:0004359)2.86405420
28Difficulty climbing stairs (HP:0003551)2.86102593
29Xanthomatosis (HP:0000991)2.85348838
30Upper limb muscle weakness (HP:0003484)2.81676648
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.81440389
32Ankle clonus (HP:0011448)2.80960039
33Death in infancy (HP:0001522)2.79121620
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.78491147
35Abnormality of alanine metabolism (HP:0010916)2.78491147
36Hyperalaninemia (HP:0003348)2.78491147
37Hypokinesia (HP:0002375)2.76433700
38Achilles tendon contracture (HP:0001771)2.70500165
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.67232624
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.67232624
41Hyperacusis (HP:0010780)2.64576084
42Cerebral hypomyelination (HP:0006808)2.57469399
43Abnormality of purine metabolism (HP:0004352)2.57091500
44Hyperammonemia (HP:0001987)2.57060432
45Megaloblastic anemia (HP:0001889)2.55747206
46Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.53860125
47Acute necrotizing encephalopathy (HP:0006965)2.53552152
48Dicarboxylic aciduria (HP:0003215)2.51371350
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51371350
50Lethargy (HP:0001254)2.45173564
51Cholecystitis (HP:0001082)2.43965648
52Abnormal gallbladder physiology (HP:0012438)2.43965648
53Irritability (HP:0000737)2.42783104
54Increased intramyocellular lipid droplets (HP:0012240)2.41419077
55Ventricular fibrillation (HP:0001663)2.41208239
56Abnormality of the intrinsic pathway (HP:0010989)2.36868170
57Multiple enchondromatosis (HP:0005701)2.35191530
58Malnutrition (HP:0004395)2.34170896
59Impulsivity (HP:0100710)2.33548066
60Progressive microcephaly (HP:0000253)2.32476806
61CNS demyelination (HP:0007305)2.30757600
62Prolonged partial thromboplastin time (HP:0003645)2.30516365
63Acute encephalopathy (HP:0006846)2.30486350
64Hepatic necrosis (HP:0002605)2.29860768
65Broad distal phalanx of finger (HP:0009836)2.28427939
66Visual hallucinations (HP:0002367)2.27454872
67Atrioventricular block (HP:0001678)2.27269949
68Mitochondrial inheritance (HP:0001427)2.26579277
69Polycythemia (HP:0001901)2.26443105
70Microretrognathia (HP:0000308)2.25918543
71Abnormality of monocarboxylic acid metabolism (HP:0010996)2.25438909
72Generalized aminoaciduria (HP:0002909)2.23865759
73Stridor (HP:0010307)2.23768882
74Cheilitis (HP:0100825)2.23728433
75Ketosis (HP:0001946)2.23615724
76Petechiae (HP:0000967)2.23335100
77Distal lower limb amyotrophy (HP:0008944)2.22271740
78Increased muscle lipid content (HP:0009058)2.20707446
79Abnormality of the Achilles tendon (HP:0005109)2.20160279
80Increased purine levels (HP:0004368)2.19979300
81Hyperuricemia (HP:0002149)2.19979300
82Bundle branch block (HP:0011710)2.19713825
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17796015
84Abnormal protein N-linked glycosylation (HP:0012347)2.17796015
85Abnormal protein glycosylation (HP:0012346)2.17796015
86Abnormal glycosylation (HP:0012345)2.17796015
87Abnormality of nucleobase metabolism (HP:0010932)2.17360049
88Restlessness (HP:0000711)2.17211955
89Abnormality of sulfur amino acid metabolism (HP:0004339)2.16033199
90Abnormal number of erythroid precursors (HP:0012131)2.14109161
91Exercise intolerance (HP:0003546)2.13888405
92Athetosis (HP:0002305)2.12958537
93Opisthotonus (HP:0002179)2.11567650
94Paraparesis (HP:0002385)2.10983989
95Ileus (HP:0002595)2.10537482
96Amblyopia (HP:0000646)2.10381500
97Hypolipoproteinemia (HP:0010981)2.09418950
98Rough bone trabeculation (HP:0100670)2.08842321
99Brushfield spots (HP:0001088)2.08616194
100IgM deficiency (HP:0002850)2.07614757
101Cerebral inclusion bodies (HP:0100314)2.07561136
102Back pain (HP:0003418)2.04731476
103Proximal tubulopathy (HP:0000114)2.04449171
104Spastic paraparesis (HP:0002313)2.02821038
105Truncal ataxia (HP:0002078)2.02738543
106Hepatocellular necrosis (HP:0001404)2.01440584
107Fasciculations (HP:0002380)2.01218723
108Increased CSF lactate (HP:0002490)2.00935745
109Cholelithiasis (HP:0001081)1.99828514
110Vertebral compression fractures (HP:0002953)1.99004944
111Premature rupture of membranes (HP:0001788)1.98870361
112Type I transferrin isoform profile (HP:0003642)1.98122569
113Diminished motivation (HP:0000745)1.96947669
114Vacuolated lymphocytes (HP:0001922)1.96213500
115Abnormality of the motor neurons (HP:0002450)1.95372732
116Abnormal neuron morphology (HP:0012757)1.95372732
117Fat malabsorption (HP:0002630)1.94693546
118Global brain atrophy (HP:0002283)1.94417070
119Abnormality of cells of the erythroid lineage (HP:0012130)1.94350575
120Emotional lability (HP:0000712)1.92475345
121Akinesia (HP:0002304)1.92392581
122Increased serum lactate (HP:0002151)1.92372148
123Ureteral duplication (HP:0000073)1.91441138
124Reduced subcutaneous adipose tissue (HP:0003758)1.90726006
125Trismus (HP:0000211)1.90511920
126Pancreatitis (HP:0001733)1.90199887
127Distal lower limb muscle weakness (HP:0009053)1.89947232
128Delusions (HP:0000746)1.89472261
129Abnormality of the umbilical cord (HP:0010881)1.88424245
130Abnormality of the vocal cords (HP:0008777)1.88314282
131Apathy (HP:0000741)1.88109554
132Diminished movement (HP:0002374)1.87854217
133Growth hormone excess (HP:0000845)1.87209663
134Hyperglycemia (HP:0003074)1.86209602
135Neonatal onset (HP:0003623)1.85694916
136Abnormality of magnesium homeostasis (HP:0004921)1.85557607
137Abnormality of glutamine family amino acid metabolism (HP:0010902)1.85441308
138Polyphagia (HP:0002591)1.85255135
139Clonus (HP:0002169)1.85246936
140Spinal rigidity (HP:0003306)1.85157227
141Thrombocytosis (HP:0001894)1.84609399
142Short nail (HP:0001799)1.83837460
143Late onset (HP:0003584)1.83691477
144Nonimmune hydrops fetalis (HP:0001790)1.83511295
145CNS hypomyelination (HP:0003429)1.83272509
146Poor suck (HP:0002033)1.82989439
147High anterior hairline (HP:0009890)1.82365123
148Sparse eyelashes (HP:0000653)1.81638351
149Hammertoe (HP:0001765)1.81225562
150Progressive macrocephaly (HP:0004481)1.80639823
151Depression (HP:0000716)1.80324515
152Abnormal platelet function (HP:0011869)1.79867142
153Impaired platelet aggregation (HP:0003540)1.79867142
154Abnormality of the gallbladder (HP:0005264)1.78942372
155Chronic otitis media (HP:0000389)1.77929997
156Posterior embryotoxon (HP:0000627)1.77855215
157Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77463947
158Hypoplasia of the brainstem (HP:0002365)1.77463947
159Hypercholesterolemia (HP:0003124)1.77240598
160Peripheral hypomyelination (HP:0007182)1.77147674
161Brittle hair (HP:0002299)1.77114575
162Long foot (HP:0001833)1.77034644
163Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.76897955
164Breast hypoplasia (HP:0003187)1.75852678
165Areflexia of lower limbs (HP:0002522)1.75351563
166Neuronal loss in central nervous system (HP:0002529)1.74786491
167Delayed CNS myelination (HP:0002188)1.74593201
168Testicular atrophy (HP:0000029)1.73802528
169Loss of speech (HP:0002371)1.73694853
170Abnormality of subcutaneous fat tissue (HP:0001001)1.73424046
171Nausea (HP:0002018)1.73316866
172Metabolic acidosis (HP:0001942)1.73167393
173Methylmalonic aciduria (HP:0012120)1.72876504
174Abnormal gallbladder morphology (HP:0012437)1.72742756
175Foot dorsiflexor weakness (HP:0009027)1.72232443
176Lower limb amyotrophy (HP:0007210)1.72185442
177Spastic tetraparesis (HP:0001285)1.71649214
178Degeneration of anterior horn cells (HP:0002398)1.71212782
179Abnormality of the anterior horn cell (HP:0006802)1.71212782
180Hypoglycemic coma (HP:0001325)1.68847843
181Muscle stiffness (HP:0003552)1.67637754
182Lactic acidosis (HP:0003128)1.67492092
183Dysautonomia (HP:0002459)1.67007550
184Increased connective tissue (HP:0009025)1.66375597
185Tongue fasciculations (HP:0001308)1.66306224
186Multiple lipomas (HP:0001012)1.65858762

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.73944765
2ERN14.22327748
3BCKDK4.04964739
4ACVR1B3.44258325
5SMG13.21189552
6VRK23.20175823
7NME22.83056809
8STK162.63658932
9TRIB32.58800283
10EIF2AK12.37127277
11AKT32.36823260
12LIMK12.31683314
13ARAF2.28738347
14PIM22.23146730
15ZAP702.17959307
16MAP2K22.15885673
17MAP2K72.10866649
18MAP4K12.10351483
19ICK2.09505248
20PINK12.08141448
21TESK22.05631880
22WEE11.97175363
23DAPK11.96471673
24MARK11.89195939
25BRAF1.83915355
26NEK21.83740018
27CASK1.82257306
28EIF2AK31.81567568
29FGFR41.80635439
30CAMKK21.79272335
31TAF11.65926117
32PAK61.64180437
33DYRK31.62490097
34CSNK1A1L1.56622736
35IRAK31.51318830
36PRKD31.49387883
37SIK21.39118584
38CSNK1G21.36383246
39SIK31.33958293
40TAOK11.31808894
41GRK51.30761343
42NTRK11.30301605
43PHKG11.28496376
44PHKG21.28496376
45TLK11.28483672
46MAP3K111.23237971
47TBK11.21433859
48PDK31.18209549
49PDK41.18209549
50DAPK31.15340105
51TYK21.14574333
52TAOK21.14101018
53PRKCI1.13348356
54TSSK61.10075194
55KDR1.07380718
56MAPKAPK31.07304059
57EPHB21.05222838
58MAP3K91.02186339
59NLK1.01382572
60NME11.00638853
61TAOK30.98239090
62BRSK10.92834827
63LMTK20.90660270
64CDK40.88426662
65EPHB10.86014815
66BRSK20.85859719
67CDK140.84181851
68PDK20.84149138
69GRK60.82763249
70CDK11A0.79854072
71TESK10.78295474
72CDK150.77483175
73DYRK20.76523622
74SYK0.76486530
75RAF10.74689155
76MAPK120.73912836
77BLK0.73554960
78MOS0.72837730
79SIK10.72524923
80PAK40.72146673
81CDK180.72076723
82AKT20.71542478
83CAMK2B0.70266213
84MAP3K40.65400268
85IRAK20.63843210
86MAP3K30.63540205
87MARK30.63429934
88MAPK40.62452295
89MAP2K40.61925650
90PDPK10.61801520
91VRK10.61567990
92LRRK20.61523345
93BTK0.61436293
94PLK10.61293805
95ZAK0.61284117
96PTK20.60987303
97PRKD20.60946071
98CDK190.60424145
99MARK20.59393778
100MAP2K60.57841367
101SRPK10.57568572
102KSR10.57430359
103JAK30.55640591
104STK240.54231696
105PAK10.52355088
106PLK40.51915095
107MAP2K10.49728062
108AURKA0.49705591
109EPHA20.49231577
110MAP3K120.49223255
111ILK0.49086076
112MAP3K50.48991807
113IKBKE0.48758289
114IRAK40.48572578
115MAP3K60.48369404
116DAPK20.48146042
117TXK0.47764343
118PRKAA10.47666585
119RPS6KA20.47539723
120PDK10.46828840
121PIM10.46005214
122MAPK110.45744623
123CDC70.45666736
124CAMKK10.45349677
125PKN10.44867968
126KSR20.44118576
127CDK50.44051965
128MAPKAPK50.43651378
129JAK10.43596909
130RPS6KA40.43273938
131MAP2K30.42913017
132MINK10.41921431
133CAMK2D0.41156968
134ABL20.39917511
135MET0.39712200
136TTN0.39362383
137MAP3K80.38561598
138TTK0.38046115
139CAMK1D0.37737405
140TGFBR10.36313000
141CSNK1G10.35834889
142UHMK10.35604084
143MAP3K100.35576633
144CHEK20.34908229
145RIPK10.34795126
146JAK20.33233763
147CCNB10.32523396
148AURKB0.31785138
149NEK10.31537406
150PRPF4B0.30651652
151CSNK1G30.29983668
152CAMK2G0.26457446
153PRKG20.24254881
154CAMK10.23022238

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.99570929
2Folate biosynthesis_Homo sapiens_hsa007904.07165469
3Sulfur relay system_Homo sapiens_hsa041223.18369557
4Synaptic vesicle cycle_Homo sapiens_hsa047212.69558537
5Caffeine metabolism_Homo sapiens_hsa002322.60236409
6Vitamin digestion and absorption_Homo sapiens_hsa049772.57805427
7RNA polymerase_Homo sapiens_hsa030202.51868139
8Regulation of autophagy_Homo sapiens_hsa041402.42695674
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.37784725
10Parkinsons disease_Homo sapiens_hsa050122.33648599
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.29059045
12Oxidative phosphorylation_Homo sapiens_hsa001902.18663722
13Proteasome_Homo sapiens_hsa030502.16822471
14Drug metabolism - other enzymes_Homo sapiens_hsa009832.14786290
15Pentose phosphate pathway_Homo sapiens_hsa000302.13746247
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06896119
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.05936444
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.86108880
19Fat digestion and absorption_Homo sapiens_hsa049751.85336955
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.82535193
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79132625
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.77061743
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.76753252
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.75056691
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.73400839
26Pyrimidine metabolism_Homo sapiens_hsa002401.67938738
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.67092152
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.65318601
29Vibrio cholerae infection_Homo sapiens_hsa051101.64814653
30Alzheimers disease_Homo sapiens_hsa050101.61015506
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58648118
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53785276
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49827112
34Biosynthesis of amino acids_Homo sapiens_hsa012301.49482286
35Fatty acid degradation_Homo sapiens_hsa000711.49249433
36Huntingtons disease_Homo sapiens_hsa050161.48498631
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48083402
38Cardiac muscle contraction_Homo sapiens_hsa042601.44727325
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.42713090
40Arginine biosynthesis_Homo sapiens_hsa002201.39238800
41Fructose and mannose metabolism_Homo sapiens_hsa000511.38015834
42Glycerolipid metabolism_Homo sapiens_hsa005611.31990455
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31168782
44Collecting duct acid secretion_Homo sapiens_hsa049661.27321024
45Carbon metabolism_Homo sapiens_hsa012001.24348311
46beta-Alanine metabolism_Homo sapiens_hsa004101.22377380
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.19441996
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15257899
49Peroxisome_Homo sapiens_hsa041461.14086514
50Cocaine addiction_Homo sapiens_hsa050301.13093732
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12708011
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12272076
53Nicotine addiction_Homo sapiens_hsa050331.11778313
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08976199
55Galactose metabolism_Homo sapiens_hsa000521.08798207
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07173197
57Sulfur metabolism_Homo sapiens_hsa009201.06686818
58Butanoate metabolism_Homo sapiens_hsa006501.05600146
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03665875
60Selenocompound metabolism_Homo sapiens_hsa004501.03513038
61Ribosome_Homo sapiens_hsa030101.00866215
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98625885
63Purine metabolism_Homo sapiens_hsa002300.95481966
64Renin-angiotensin system_Homo sapiens_hsa046140.95319621
65Propanoate metabolism_Homo sapiens_hsa006400.94611886
66Fatty acid metabolism_Homo sapiens_hsa012120.92410180
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92106583
68Histidine metabolism_Homo sapiens_hsa003400.89797915
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89595355
70Tryptophan metabolism_Homo sapiens_hsa003800.87556090
71Protein export_Homo sapiens_hsa030600.86723771
72PPAR signaling pathway_Homo sapiens_hsa033200.85887184
73Dopaminergic synapse_Homo sapiens_hsa047280.84906702
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81539508
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.80990424
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79949230
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79585481
78Glutathione metabolism_Homo sapiens_hsa004800.78252628
79Metabolic pathways_Homo sapiens_hsa011000.76826439
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76383047
81Shigellosis_Homo sapiens_hsa051310.74870942
82Alcoholism_Homo sapiens_hsa050340.73162463
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72769842
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72748101
85AMPK signaling pathway_Homo sapiens_hsa041520.71576940
86Arginine and proline metabolism_Homo sapiens_hsa003300.69658128
87Primary immunodeficiency_Homo sapiens_hsa053400.68904968
88Bladder cancer_Homo sapiens_hsa052190.68791703
89Prion diseases_Homo sapiens_hsa050200.66514174
90RNA transport_Homo sapiens_hsa030130.66289972
91Starch and sucrose metabolism_Homo sapiens_hsa005000.65860016
92GABAergic synapse_Homo sapiens_hsa047270.65681653
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63431227
94Mineral absorption_Homo sapiens_hsa049780.63024618
95Nitrogen metabolism_Homo sapiens_hsa009100.62864857
96Lysosome_Homo sapiens_hsa041420.62547052
97N-Glycan biosynthesis_Homo sapiens_hsa005100.61811724
98Amphetamine addiction_Homo sapiens_hsa050310.60488087
99Circadian rhythm_Homo sapiens_hsa047100.58587072
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58438443
101ABC transporters_Homo sapiens_hsa020100.57525256
102Chemical carcinogenesis_Homo sapiens_hsa052040.57390010
103Fatty acid elongation_Homo sapiens_hsa000620.56800899
104Pyruvate metabolism_Homo sapiens_hsa006200.55786046
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55640410
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.55530787
107Endocytosis_Homo sapiens_hsa041440.54272824
108Base excision repair_Homo sapiens_hsa034100.53613726
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.52322801
110Insulin signaling pathway_Homo sapiens_hsa049100.51255213
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50867122
112Bile secretion_Homo sapiens_hsa049760.50246337
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48028656
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46281811
115Long-term potentiation_Homo sapiens_hsa047200.45876329
116Retinol metabolism_Homo sapiens_hsa008300.45753967
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45440794
118p53 signaling pathway_Homo sapiens_hsa041150.44562073
119Gap junction_Homo sapiens_hsa045400.44325682
120VEGF signaling pathway_Homo sapiens_hsa043700.43503045
121ErbB signaling pathway_Homo sapiens_hsa040120.43447034
122Axon guidance_Homo sapiens_hsa043600.42267173
123Oocyte meiosis_Homo sapiens_hsa041140.41251944
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40444621
125Tyrosine metabolism_Homo sapiens_hsa003500.40106464
126GnRH signaling pathway_Homo sapiens_hsa049120.39216861
127Salmonella infection_Homo sapiens_hsa051320.37357978
128Phenylalanine metabolism_Homo sapiens_hsa003600.37006592
129Other glycan degradation_Homo sapiens_hsa005110.36331033
130Circadian entrainment_Homo sapiens_hsa047130.36201764
131Morphine addiction_Homo sapiens_hsa050320.36161598
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35973309
133Gastric acid secretion_Homo sapiens_hsa049710.35749972
134Complement and coagulation cascades_Homo sapiens_hsa046100.35014965
135DNA replication_Homo sapiens_hsa030300.33869079
136Thyroid cancer_Homo sapiens_hsa052160.33670869
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33309469
138Inositol phosphate metabolism_Homo sapiens_hsa005620.32977078
139Epstein-Barr virus infection_Homo sapiens_hsa051690.32852444
140Estrogen signaling pathway_Homo sapiens_hsa049150.32756662
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32691875
142Glioma_Homo sapiens_hsa052140.32653160
143Glutamatergic synapse_Homo sapiens_hsa047240.31838252
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.31687165
145Sphingolipid metabolism_Homo sapiens_hsa006000.31686848
146Insulin resistance_Homo sapiens_hsa049310.30051911
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29356306
148Spliceosome_Homo sapiens_hsa030400.28166823
149Antigen processing and presentation_Homo sapiens_hsa046120.27404809
150Nucleotide excision repair_Homo sapiens_hsa034200.27055629
151Legionellosis_Homo sapiens_hsa051340.26904907
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.24791818
153Glycosaminoglycan degradation_Homo sapiens_hsa005310.22898834
154Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21920913
155RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20334221
156Cell cycle_Homo sapiens_hsa041100.18156778

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