MORC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)7.45876696
2DNA methylation involved in gamete generation (GO:0043046)7.20705605
3male meiosis (GO:0007140)6.92438375
4acrosome reaction (GO:0007340)6.70192896
5male meiosis I (GO:0007141)6.58599171
6sperm motility (GO:0030317)6.17617688
7chromosome organization involved in meiosis (GO:0070192)6.08780946
8meiosis I (GO:0007127)6.06903229
9synaptonemal complex organization (GO:0070193)6.01185842
10protein neddylation (GO:0045116)5.81172973
11thrombin receptor signaling pathway (GO:0070493)5.79635134
12synapsis (GO:0007129)5.59305404
13plasma membrane fusion (GO:0045026)5.52412211
14microtubule depolymerization (GO:0007019)5.36485533
15regulation of posttranscriptional gene silencing (GO:0060147)5.35697640
16regulation of gene silencing by miRNA (GO:0060964)5.35697640
17regulation of gene silencing by RNA (GO:0060966)5.35697640
18nuclear pore organization (GO:0006999)5.07671820
19meiotic nuclear division (GO:0007126)4.97588662
20adenosine receptor signaling pathway (GO:0001973)4.82092684
21nuclear pore complex assembly (GO:0051292)4.80600071
22regulation of helicase activity (GO:0051095)4.76919411
23DNA replication initiation (GO:0006270)4.76224315
24DNA replication-dependent nucleosome organization (GO:0034723)4.72160051
25DNA replication-dependent nucleosome assembly (GO:0006335)4.72160051
26protein targeting to Golgi (GO:0000042)4.57634120
27somatic diversification of immune receptors via somatic mutation (GO:0002566)4.56663899
28somatic hypermutation of immunoglobulin genes (GO:0016446)4.56663899
29establishment of protein localization to Golgi (GO:0072600)4.53750195
30retrograde transport, vesicle recycling within Golgi (GO:0000301)4.52663293
31protein localization to kinetochore (GO:0034501)4.51156942
32mitotic metaphase plate congression (GO:0007080)4.46392239
33neutrophil activation involved in immune response (GO:0002283)4.46221583
34regulation of meiosis I (GO:0060631)4.40192944
35negative regulation of inclusion body assembly (GO:0090084)4.38118371
36regulation of platelet activation (GO:0010543)4.37897327
37negative regulation of norepinephrine secretion (GO:0010700)4.34935531
38triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.29431319
39regulation of cilium movement (GO:0003352)4.28168401
40regulation of platelet aggregation (GO:0090330)4.26118666
41multicellular organism reproduction (GO:0032504)4.17136779
42mitotic nuclear envelope disassembly (GO:0007077)4.14505788
43DNA replication checkpoint (GO:0000076)4.12681666
44DNA strand elongation involved in DNA replication (GO:0006271)4.11673705
45G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.10910654
46negative regulation of homotypic cell-cell adhesion (GO:0034111)4.09844969
47microtubule polymerization or depolymerization (GO:0031109)4.07988508
48nucleobase biosynthetic process (GO:0046112)4.07608411
49ribosome assembly (GO:0042255)4.07607298
50negative regulation of platelet activation (GO:0010544)4.03408556
51polyamine biosynthetic process (GO:0006596)4.00817456
52folic acid-containing compound biosynthetic process (GO:0009396)3.99122970
53protein K6-linked ubiquitination (GO:0085020)3.99085079
54regulation of integrin activation (GO:0033623)3.98151216
55formation of translation preinitiation complex (GO:0001731)3.97988993
56cilium or flagellum-dependent cell motility (GO:0001539)3.97227987
57DNA unwinding involved in DNA replication (GO:0006268)3.96525751
58positive regulation of endothelial cell differentiation (GO:0045603)3.93437654
59sperm-egg recognition (GO:0035036)3.92822602
60IMP biosynthetic process (GO:0006188)3.90971656
61DNA strand elongation (GO:0022616)3.88910867
62spermatid development (GO:0007286)3.88856476
63purine nucleobase biosynthetic process (GO:0009113)3.87581714
64nuclear envelope disassembly (GO:0051081)3.87205272
65membrane disassembly (GO:0030397)3.87205272
66determination of adult lifespan (GO:0008340)3.87199598
67metaphase plate congression (GO:0051310)3.87069049
68telomere maintenance via semi-conservative replication (GO:0032201)3.82888386
69ribosome biogenesis (GO:0042254)3.81884969
70positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.72924042
71histone H4-K12 acetylation (GO:0043983)3.72745762
72protein localization to chromosome, centromeric region (GO:0071459)3.72353920
73purinergic nucleotide receptor signaling pathway (GO:0035590)3.72090872
74regulation of nuclear cell cycle DNA replication (GO:0033262)3.67703162
75regulation of histone H3-K9 methylation (GO:0051570)3.65870714
76maturation of SSU-rRNA (GO:0030490)3.65227075
77blood coagulation, intrinsic pathway (GO:0007597)3.65193566
78mitotic sister chromatid segregation (GO:0000070)3.62955077
79chromatin remodeling at centromere (GO:0031055)3.61106094
80pore complex assembly (GO:0046931)3.60976978
81DNA geometric change (GO:0032392)3.60306811
82centriole assembly (GO:0098534)3.60273763
83meiotic cell cycle process (GO:1903046)3.59836745
84DNA synthesis involved in DNA repair (GO:0000731)3.59818732
85DNA duplex unwinding (GO:0032508)3.58015955
86* spermatogenesis (GO:0007283)3.57542348
87* male gamete generation (GO:0048232)3.56651870
88negative regulation of histone methylation (GO:0031061)3.55510880
89centriole replication (GO:0007099)3.51543899
90heterochromatin organization (GO:0070828)3.50863994
91mitotic chromosome condensation (GO:0007076)3.48801167
92single strand break repair (GO:0000012)3.47967653
93reproduction (GO:0000003)3.47692948
94calcium ion-dependent exocytosis (GO:0017156)3.45632256
95DNA packaging (GO:0006323)3.44203242
96platelet aggregation (GO:0070527)3.43524805
97IMP metabolic process (GO:0046040)3.42959030
98protein localization to Golgi apparatus (GO:0034067)3.41353737
99telomere maintenance via recombination (GO:0000722)3.38888453
100ribonucleoprotein complex biogenesis (GO:0022613)3.38251387
101regulation of centrosome cycle (GO:0046605)3.36913300
102* gamete generation (GO:0007276)3.35080741
103regulation of centriole replication (GO:0046599)3.34975129
104kinetochore organization (GO:0051383)3.33952499
105regulation of mitotic spindle organization (GO:0060236)3.33236838
106regulation of spindle organization (GO:0090224)3.32736398
107attachment of spindle microtubules to kinetochore (GO:0008608)3.32623698
108telomere maintenance via telomere lengthening (GO:0010833)3.32131799
109establishment of chromosome localization (GO:0051303)3.32063656
110tyrosine metabolic process (GO:0006570)3.31370965
111CENP-A containing nucleosome assembly (GO:0034080)3.31053184
112regulation of telomere maintenance via telomerase (GO:0032210)3.29910080
113mitotic recombination (GO:0006312)3.29909178
114meiotic chromosome segregation (GO:0045132)3.29191220
115binding of sperm to zona pellucida (GO:0007339)3.27848596
116spermatid nucleus differentiation (GO:0007289)3.26749018
117response to acidic pH (GO:0010447)3.26363363
118sperm capacitation (GO:0048240)3.24978508
119positive regulation of chromosome segregation (GO:0051984)3.24844088
120fertilization (GO:0009566)3.24382232
121negative regulation of heart rate (GO:0010459)3.24096158
122histone H3-K9 demethylation (GO:0033169)3.23270845
123DNA replication-independent nucleosome organization (GO:0034724)3.23014597
124DNA replication-independent nucleosome assembly (GO:0006336)3.23014597
125negative regulation of appetite (GO:0032099)3.22370475
126negative regulation of response to food (GO:0032096)3.22370475
127leukocyte migration involved in inflammatory response (GO:0002523)3.21930163
128regulation of microtubule-based movement (GO:0060632)3.20787096
129tonic smooth muscle contraction (GO:0014820)3.19146660
130regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19140305
131motile cilium assembly (GO:0044458)3.18242837
132kinetochore assembly (GO:0051382)3.18115327
133sister chromatid segregation (GO:0000819)3.17657706
134regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17452460
135positive regulation of SMAD protein import into nucleus (GO:0060391)3.17231416
136regulation of double-strand break repair via homologous recombination (GO:0010569)3.17032484
137regulation of translational fidelity (GO:0006450)3.17023071
138piRNA metabolic process (GO:0034587)3.16887429
139regulation of gene silencing (GO:0060968)3.16843812
140regulation of T-helper 2 cell differentiation (GO:0045628)3.15938470
141pre-miRNA processing (GO:0031054)3.14183826
142negative regulation of chromosome segregation (GO:0051985)3.14138180
143platelet formation (GO:0030220)3.13175195
144regulation of Golgi to plasma membrane protein transport (GO:0042996)3.13079011
145chromosome condensation (GO:0030261)3.12880396
146positive regulation of mast cell activation (GO:0033005)3.12816527
147maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12543070
148cellular biogenic amine biosynthetic process (GO:0042401)3.11988906
149histone arginine methylation (GO:0034969)3.11682114
150nucleotide-excision repair, DNA gap filling (GO:0006297)3.10996812
151mismatch repair (GO:0006298)3.10731395
152reciprocal meiotic recombination (GO:0007131)3.10606127
153reciprocal DNA recombination (GO:0035825)3.10606127
154regulation of memory T cell differentiation (GO:0043380)3.09363000
155histone exchange (GO:0043486)3.09234232
156cell-cell recognition (GO:0009988)3.08904355
157regulation of chromosome segregation (GO:0051983)3.08770552
158low-density lipoprotein particle remodeling (GO:0034374)3.06965534
159establishment of integrated proviral latency (GO:0075713)3.06281147
160intra-S DNA damage checkpoint (GO:0031573)3.04955840
161regulation of integrin-mediated signaling pathway (GO:2001044)3.03823489
162ribosomal large subunit biogenesis (GO:0042273)3.03198841
163paraxial mesoderm development (GO:0048339)3.01957410
164regulation of female receptivity (GO:0045924)3.01374105
165negative regulation of mitotic sister chromatid separation (GO:2000816)3.00879993
166negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00879993
167negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00879993
168negative regulation of sister chromatid segregation (GO:0033046)3.00879993
169protein polyglutamylation (GO:0018095)3.00261227
170purinergic receptor signaling pathway (GO:0035587)3.00058059
171negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.99680729
172anterior/posterior axis specification, embryo (GO:0008595)2.99424662
173histone H3-K36 demethylation (GO:0070544)2.99266962
174termination of G-protein coupled receptor signaling pathway (GO:0038032)2.99228371
175rRNA processing (GO:0006364)2.98322724
176spindle checkpoint (GO:0031577)2.97938146
177negative regulation of androgen receptor signaling pathway (GO:0060766)2.96260663
178superoxide anion generation (GO:0042554)2.95532850
179positive regulation of meiosis (GO:0045836)2.95488027
180chromatin assembly (GO:0031497)2.94399295
181chromatin assembly or disassembly (GO:0006333)2.94397861
182mitotic spindle checkpoint (GO:0071174)2.94226529
183chaperone-mediated protein complex assembly (GO:0051131)2.93432150
184negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.92839883
185regulation of sister chromatid cohesion (GO:0007063)2.92833391
186maturation of 5.8S rRNA (GO:0000460)2.92752652
187regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92552305
188synaptonemal complex assembly (GO:0007130)2.91967528
189regulation of T-helper 1 cell differentiation (GO:0045625)2.91684339
190regulation of interleukin-13 production (GO:0032656)2.91643652
191regulation of inclusion body assembly (GO:0090083)2.90382259
192resolution of meiotic recombination intermediates (GO:0000712)2.90022561
193negative regulation of thymocyte apoptotic process (GO:0070244)2.89544774
194amine biosynthetic process (GO:0009309)2.88649823
195G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.88304017
196axonemal dynein complex assembly (GO:0070286)2.87188515

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.69875052
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.05096231
3SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.78224071
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.76809419
5EZH2_22144423_ChIP-Seq_EOC_Human3.72357240
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35442093
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.34574645
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.34574645
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.34574645
10* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.23694792
11* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.98578219
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.84278963
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74687503
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67656261
15NANOG_18555785_ChIP-Seq_MESCs_Mouse2.60334161
16SCL_19346495_ChIP-Seq_HPC-7_Human2.57733431
17NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.57432627
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.57053774
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.45417855
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43650863
21TAF15_26573619_Chip-Seq_HEK293_Human2.42536437
22GBX2_23144817_ChIP-Seq_PC3_Human2.39725640
23GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.37321414
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34293943
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.33887365
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.28952915
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.27852504
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24861656
29* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.21685874
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.20065027
31* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.18881427
32EST1_17652178_ChIP-ChIP_JURKAT_Human2.17042567
33POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.16907438
34* STAT3_1855785_ChIP-Seq_MESCs_Mouse2.15324473
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15043548
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12471194
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05478503
38ETS1_20019798_ChIP-Seq_JURKAT_Human2.01689780
39SOX2_18555785_ChIP-Seq_MESCs_Mouse2.01614154
40ER_23166858_ChIP-Seq_MCF-7_Human2.00208297
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00014610
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98506183
43* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.98198647
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95434564
45SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.94853002
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92281165
47VDR_22108803_ChIP-Seq_LS180_Human1.91961343
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90278173
49* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.90081888
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88790369
51* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87728066
52XRN2_22483619_ChIP-Seq_HELA_Human1.86902685
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86608690
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.86351087
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83179051
56HTT_18923047_ChIP-ChIP_STHdh_Human1.81917061
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81765758
58* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.81470829
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79521705
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.78682269
61AR_25329375_ChIP-Seq_VCAP_Human1.77045159
62GATA1_19941826_ChIP-Seq_K562_Human1.74422235
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.73666199
64AR_21909140_ChIP-Seq_LNCAP_Human1.72857989
65NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.72009955
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71217405
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.71217405
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.69555151
69* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.64984222
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61820523
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.60480086
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60186828
73IGF1R_20145208_ChIP-Seq_DFB_Human1.59159759
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57089314
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56971395
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55040799
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.54323146
78VDR_23849224_ChIP-Seq_CD4+_Human1.53337159
79GATA2_19941826_ChIP-Seq_K562_Human1.52053512
80SMAD4_21799915_ChIP-Seq_A2780_Human1.50163923
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.49986801
82RUNX_20019798_ChIP-Seq_JUKART_Human1.48476089
83KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.47224429
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45349524
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.45194384
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45157292
87* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.44997497
88THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44839642
89* STAT3_23295773_ChIP-Seq_U87_Human1.43826026
90P300_19829295_ChIP-Seq_ESCs_Human1.43475137
91* SALL4_22934838_ChIP-ChIP_CD34+_Human1.39958827
92NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.39780533
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39722444
94POU5F1_16518401_ChIP-PET_MESCs_Mouse1.39386449
95FUS_26573619_Chip-Seq_HEK293_Human1.38023378
96* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.37421483
97TTF2_22483619_ChIP-Seq_HELA_Human1.37005811
98* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.36548822
99FOXP3_21729870_ChIP-Seq_TREG_Human1.36149212
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35061609
101NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33628127
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32873220
103FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31628636
104BCAT_22108803_ChIP-Seq_LS180_Human1.30743025
105* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30733134
106DCP1A_22483619_ChIP-Seq_HELA_Human1.30240941
107NANOG_21062744_ChIP-ChIP_HESCs_Human1.29926524
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.29880207
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29180874
110ELK4_26923725_Chip-Seq_MESODERM_Mouse1.29113637
111RNF2_27304074_Chip-Seq_NSC_Mouse1.28569696
112SMRT_27268052_Chip-Seq_Bcells_Human1.28508587
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28303958
114* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.27294303
115OCT1_27270436_Chip-Seq_PROSTATE_Human1.26571265
116GABP_19822575_ChIP-Seq_HepG2_Human1.26356542
117MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26045154
118RUNX1_26923725_Chip-Seq_HPCs_Mouse1.25634213
119* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25616116
120GATA1_19941827_ChIP-Seq_MEL_Mouse1.24519725
121CBP_20019798_ChIP-Seq_JUKART_Human1.24088225
122IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24088225
123ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23474751
124ARNT_22903824_ChIP-Seq_MCF-7_Human1.23274278
125TCF4_23295773_ChIP-Seq_U87_Human1.23012796
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22060177
127SMAD4_21741376_ChIP-Seq_EPCs_Human1.21279400
128RBPJ_21746931_ChIP-Seq_IB4_Human1.21271186
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21258480
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21093230
131NFYB_21822215_ChIP-Seq_K562_Human1.20704945
132SPI1_23127762_ChIP-Seq_K562_Human1.19919816
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19804198
134ETV1_20927104_ChIP-Seq_GIST48_Human1.19708812
135TDRD3_21172665_ChIP-Seq_MCF-7_Human1.19476925
136* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.19411001
137TBL1_22424771_ChIP-Seq_293T_Human1.18886323
138RUNX2_22187159_ChIP-Seq_PCA_Human1.18076964
139GATA1_19941827_ChIP-Seq_MEL86_Mouse1.17862578
140HNFA_21074721_ChIP-Seq_CACO-2_Human1.17363590
141KDM5A_27292631_Chip-Seq_BREAST_Human1.17064348
142CBX2_22325352_ChIP-Seq_293T-Rex_Human1.14928142
143MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13860623
144ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13104676
145GATA3_21878914_ChIP-Seq_MCF-7_Human1.12853150
146CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.12560105
147PHF8_20622853_ChIP-Seq_HELA_Human1.11766495
148HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11677803
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11194160
150NANOG_19829295_ChIP-Seq_ESCs_Human1.11190723
151SOX2_19829295_ChIP-Seq_ESCs_Human1.11190723
152TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.11151630
153EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.10150634
154PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10114810
155CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09930709
156SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09539323
157FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08446840
158TCF4_18268006_ChIP-ChIP_LS174T_Human1.07916982
159ELK1_19687146_ChIP-ChIP_HELA_Human1.07853066
160ERG_20517297_ChIP-Seq_VCAP_Human1.07618788
161PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07346161
162* KAP1_27257070_Chip-Seq_ESCs_Mouse1.06995311
163GATA3_26560356_Chip-Seq_TH1_Human1.05157008
164PRDM14_20953172_ChIP-Seq_ESCs_Human1.05125448
165TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.04427847
166NFYA_21822215_ChIP-Seq_K562_Human1.04321237
167FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03811643
168FOXA1_25329375_ChIP-Seq_VCAP_Human1.03811643
169TP63_19390658_ChIP-ChIP_HaCaT_Human1.03306504
170JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03212430
171TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02828228
172IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02676340
173TFEB_21752829_ChIP-Seq_HELA_Human1.02235085
174* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01910395
175YY1_22570637_ChIP-Seq_MALME-3M_Human1.01590030
176NANOG_20526341_ChIP-Seq_ESCs_Human1.01280725
177TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00811416
178FLI1_27457419_Chip-Seq_LIVER_Mouse1.00282443
179CDX2_22108803_ChIP-Seq_LS180_Human0.99891661
180GATA2_21666600_ChIP-Seq_HMVEC_Human0.99783951
181VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97441217
182TAF2_19829295_ChIP-Seq_ESCs_Human0.97131301
183CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96889565
184TP63_23658742_ChIP-Seq_EP156T_Human0.96796636
185POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96724230
186NANOG_16518401_ChIP-PET_MESCs_Mouse0.96635547
187CEBPB_22108803_ChIP-Seq_LS180_Human0.95584983
188NANOG_18555785_Chip-Seq_ESCs_Mouse0.95365961
189HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93058580
190CIITA_25753668_ChIP-Seq_RAJI_Human0.92578095
191MYC_22102868_ChIP-Seq_BL_Human0.89704317
192PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89231108
193RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89216953
194SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88070602
195RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85646149
196DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85189236
197CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84619753
198* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.84612095
199CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83624319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology7.47057964
2MP0005410_abnormal_fertilization6.25532332
3MP0008057_abnormal_DNA_replication4.82453115
4MP0010094_abnormal_chromosome_stability4.69431723
5MP0003693_abnormal_embryo_hatching4.58302666
6MP0008004_abnormal_stomach_pH4.55630028
7MP0004957_abnormal_blastocyst_morpholog4.37581990
8MP0003111_abnormal_nucleus_morphology4.29317016
9MP0003077_abnormal_cell_cycle3.78429473
10MP0003806_abnormal_nucleotide_metabolis3.69722926
11MP0008058_abnormal_DNA_repair3.54226435
12MP0008877_abnormal_DNA_methylation2.87738359
13MP0010352_gastrointestinal_tract_polyps2.76739434
14MP0009697_abnormal_copulation2.71930947
15MP0004133_heterotaxia2.61138585
16MP0005083_abnormal_biliary_tract2.59346888
17MP0002653_abnormal_ependyma_morphology2.54883119
18MP0003123_paternal_imprinting2.53961424
19MP0001730_embryonic_growth_arrest2.48116072
20MP0000350_abnormal_cell_proliferation2.40754072
21MP0008932_abnormal_embryonic_tissue2.39347300
22MP0008007_abnormal_cellular_replicative2.30053101
23MP0005167_abnormal_blood-brain_barrier2.28708829
24MP0003724_increased_susceptibility_to2.27731830
25MP0003786_premature_aging2.21386577
26MP0000465_gastrointestinal_hemorrhage2.18689250
27MP0010307_abnormal_tumor_latency2.18152900
28MP0005171_absent_coat_pigmentation2.07879206
29MP0003718_maternal_effect2.03376230
30MP0000230_abnormal_systemic_arterial1.97146869
31MP0000343_altered_response_to1.97081306
32MP0001672_abnormal_embryogenesis/_devel1.96530716
33MP0005380_embryogenesis_phenotype1.96530716
34MP0001835_abnormal_antigen_presentation1.94914565
35MP0002084_abnormal_developmental_patter1.92988445
36MP0002085_abnormal_embryonic_tissue1.91452966
37MP0003283_abnormal_digestive_organ1.85987428
38MP0003136_yellow_coat_color1.85140654
39MP0003941_abnormal_skin_development1.83851531
40MP0006276_abnormal_autonomic_nervous1.81035147
41MP0001697_abnormal_embryo_size1.80800479
42MP0003890_abnormal_embryonic-extraembry1.77438909
43* MP0002210_abnormal_sex_determination1.72683497
44MP0002086_abnormal_extraembryonic_tissu1.71264104
45MP0004197_abnormal_fetal_growth/weight/1.71112279
46MP0002736_abnormal_nociception_after1.70722950
47MP0004036_abnormal_muscle_relaxation1.70513505
48MP0004510_myositis1.65055123
49MP0003984_embryonic_growth_retardation1.64024193
50MP0000015_abnormal_ear_pigmentation1.63797062
51MP0006292_abnormal_olfactory_placode1.62353252
52MP0002088_abnormal_embryonic_growth/wei1.60281992
53MP0002080_prenatal_lethality1.59506225
54MP0004084_abnormal_cardiac_muscle1.58509509
55* MP0001145_abnormal_male_reproductive1.56853972
56MP0001293_anophthalmia1.56409401
57MP0005670_abnormal_white_adipose1.55174135
58MP0003119_abnormal_digestive_system1.54551810
59MP0003121_genomic_imprinting1.50829891
60MP0005174_abnormal_tail_pigmentation1.49822353
61MP0001879_abnormal_lymphatic_vessel1.49510762
62MP0003646_muscle_fatigue1.49304781
63MP0001968_abnormal_touch/_nociception1.46698477
64MP0003638_abnormal_response/metabolism_1.46324410
65MP0000383_abnormal_hair_follicle1.42996953
66* MP0001929_abnormal_gametogenesis1.42384948
67MP0003303_peritoneal_inflammation1.40769858
68MP0001545_abnormal_hematopoietic_system1.39459677
69MP0005397_hematopoietic_system_phenotyp1.39459677
70MP0005076_abnormal_cell_differentiation1.37009726
71MP0000249_abnormal_blood_vessel1.34651388
72MP0005646_abnormal_pituitary_gland1.31857951
73MP0005266_abnormal_metabolism1.31562270
74MP0003879_abnormal_hair_cell1.31488943
75MP0005409_darkened_coat_color1.30848180
76* MP0000653_abnormal_sex_gland1.29391787
77MP0004484_altered_response_of1.28086963
78MP0002132_abnormal_respiratory_system1.26625110
79MP0008775_abnormal_heart_ventricle1.24938719
80* MP0000313_abnormal_cell_death1.22719745
81MP0003705_abnormal_hypodermis_morpholog1.22517321
82MP0008872_abnormal_physiological_respon1.22399519
83MP0001765_abnormal_ion_homeostasis1.21680857
84MP0003195_calcinosis1.20405516
85MP0002148_abnormal_hypersensitivity_rea1.17568430
86MP0001849_ear_inflammation1.17471558
87MP0002019_abnormal_tumor_incidence1.14926070
88MP0004264_abnormal_extraembryonic_tissu1.12301192
89MP0002733_abnormal_thermal_nociception1.12267681
90MP0003828_pulmonary_edema1.08811361
91MP0003567_abnormal_fetal_cardiomyocyte1.08161070
92MP0000372_irregular_coat_pigmentation1.06967572
93MP0003566_abnormal_cell_adhesion1.06620679
94MP0000490_abnormal_crypts_of1.06006667
95MP0005310_abnormal_salivary_gland1.05837624
96MP0009278_abnormal_bone_marrow1.04811715
97MP0004130_abnormal_muscle_cell1.01954426
98MP0005671_abnormal_response_to1.01241758
99MP0010030_abnormal_orbit_morphology1.01107674
100* MP0003698_abnormal_male_reproductive0.98359993
101MP0003186_abnormal_redox_activity0.94414596
102MP0005084_abnormal_gallbladder_morpholo0.94336737
103MP0004808_abnormal_hematopoietic_stem0.94193344
104MP0003787_abnormal_imprinting0.93424710
105MP0010368_abnormal_lymphatic_system0.92511127
106MP0004215_abnormal_myocardial_fiber0.92469832
107MP0002160_abnormal_reproductive_system0.92453353
108MP0003315_abnormal_perineum_morphology0.91953277
109MP0008995_early_reproductive_senescence0.89673584
110MP0005377_hearing/vestibular/ear_phenot0.89342195
111MP0003878_abnormal_ear_physiology0.89342195
112MP0005023_abnormal_wound_healing0.89256982
113MP0001663_abnormal_digestive_system0.88683267
114MP0010155_abnormal_intestine_physiology0.87524357
115MP0005367_renal/urinary_system_phenotyp0.87030551
116MP0000516_abnormal_urinary_system0.87030551
117MP0002111_abnormal_tail_morphology0.86356176
118MP0001119_abnormal_female_reproductive0.84945093
119MP0002398_abnormal_bone_marrow0.84837873
120MP0004742_abnormal_vestibular_system0.82482713
121MP0005389_reproductive_system_phenotype0.82450206
122MP0001286_abnormal_eye_development0.81575334
123MP0005384_cellular_phenotype0.81479988
124MP0000358_abnormal_cell_content/0.81085206
125MP0003936_abnormal_reproductive_system0.80762161
126MP0001970_abnormal_pain_threshold0.78878707
127* MP0002161_abnormal_fertility/fecundity0.78237959
128MP0009764_decreased_sensitivity_to0.78092347
129MP0004085_abnormal_heartbeat0.77728167
130MP0008874_decreased_physiological_sensi0.77440074
131MP0005621_abnormal_cell_physiology0.77379171
132MP0005000_abnormal_immune_tolerance0.77263880
133MP0005647_abnormal_sex_gland0.76970612
134MP0005551_abnormal_eye_electrophysiolog0.76044167
135MP0003861_abnormal_nervous_system0.75220501
136MP0005501_abnormal_skin_physiology0.74703405
137MP0002723_abnormal_immune_serum0.74279352
138MP0009703_decreased_birth_body0.74222176
139MP0010234_abnormal_vibrissa_follicle0.74158502
140MP0001664_abnormal_digestion0.74058464
141MP0010329_abnormal_lipoprotein_level0.73956854
142MP0001485_abnormal_pinna_reflex0.73803756
143MP0003937_abnormal_limbs/digits/tail_de0.73164905
144MP0005395_other_phenotype0.72690134
145MP0004947_skin_inflammation0.71820694
146MP0001915_intracranial_hemorrhage0.71022732
147MP0002396_abnormal_hematopoietic_system0.70923821
148MP0002697_abnormal_eye_size0.69319427
149MP0000432_abnormal_head_morphology0.68800522
150MP0001800_abnormal_humoral_immune0.68334698
151MP0003699_abnormal_female_reproductive0.67875073
152MP0006072_abnormal_retinal_apoptosis0.67739915
153MP0000537_abnormal_urethra_morphology0.66977119
154MP0005623_abnormal_meninges_morphology0.66971198
155MP0002269_muscular_atrophy0.66691729
156MP0002092_abnormal_eye_morphology0.66423988
157MP0002735_abnormal_chemical_nociception0.65502169
158MP0010678_abnormal_skin_adnexa0.65390819
159MP0006035_abnormal_mitochondrial_morpho0.64871049
160MP0002277_abnormal_respiratory_mucosa0.64657758
161MP0000371_diluted_coat_color0.64386766
162MP0002796_impaired_skin_barrier0.64004958
163MP0001851_eye_inflammation0.63637727
164MP0000569_abnormal_digit_pigmentation0.62482256
165MP0002127_abnormal_cardiovascular_syste0.61935908
166MP0002089_abnormal_postnatal_growth/wei0.61731753
167MP0002452_abnormal_antigen_presenting0.61215993
168MP0002332_abnormal_exercise_endurance0.61099308
169MP0004185_abnormal_adipocyte_glucose0.60566734
170MP0002972_abnormal_cardiac_muscle0.59953509
171MP0002075_abnormal_coat/hair_pigmentati0.59847271
172MP0009053_abnormal_anal_canal0.59200340
173MP0002998_abnormal_bone_remodeling0.59140231
174MP0005058_abnormal_lysosome_morphology0.58578987
175MP0009642_abnormal_blood_homeostasis0.58256972
176MP0003755_abnormal_palate_morphology0.58107857
177MP0002249_abnormal_larynx_morphology0.57779227
178MP0003453_abnormal_keratinocyte_physiol0.56942471
179MP0001919_abnormal_reproductive_system0.56337606
180MP0003950_abnormal_plasma_membrane0.56059395
181MP0009763_increased_sensitivity_to0.54292275

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)8.94741602
2Menorrhagia (HP:0000132)7.94701992
3Increased mean platelet volume (HP:0011877)7.56831788
4Petechiae (HP:0000967)7.10656844
5Abnormal platelet volume (HP:0011876)7.09542407
6Purpura (HP:0000979)6.54996477
7Epistaxis (HP:0000421)6.05182226
8Ependymoma (HP:0002888)5.70290500
9Gingival bleeding (HP:0000225)5.35756753
10Spontaneous hematomas (HP:0007420)5.13541570
11Hyperlipoproteinemia (HP:0010980)4.85916573
12Impaired platelet aggregation (HP:0003540)4.85813578
13Abnormal platelet function (HP:0011869)4.85813578
14Abnormality of the labia minora (HP:0012880)4.85324086
15Birth length less than 3rd percentile (HP:0003561)4.77490855
16Breast hypoplasia (HP:0003187)4.48447482
17Chromsome breakage (HP:0040012)4.13162532
18Medulloblastoma (HP:0002885)4.13025933
19Chromosomal breakage induced by crosslinking agents (HP:0003221)4.12404253
20Astrocytoma (HP:0009592)4.11052091
21Abnormality of the astrocytes (HP:0100707)4.11052091
22Agnosia (HP:0010524)3.89698709
23Supernumerary spleens (HP:0009799)3.88374858
24Absent/shortened dynein arms (HP:0200106)3.86797670
25Dynein arm defect of respiratory motile cilia (HP:0012255)3.86797670
26Poikilocytosis (HP:0004447)3.76268864
27Neoplasm of the oral cavity (HP:0100649)3.75754460
28Absent radius (HP:0003974)3.75425165
29Rhabdomyosarcoma (HP:0002859)3.75036620
30Severe visual impairment (HP:0001141)3.72378036
31Decreased central vision (HP:0007663)3.67158489
32Acanthocytosis (HP:0001927)3.58010926
33Absent forearm bone (HP:0003953)3.52318793
34Aplasia involving forearm bones (HP:0009822)3.52318793
35Abnormal ciliary motility (HP:0012262)3.52103132
36Glioma (HP:0009733)3.48224495
37Dyschromatopsia (HP:0007641)3.42092645
38Male infertility (HP:0003251)3.39422973
39Selective tooth agenesis (HP:0001592)3.36284395
40Carpal bone hypoplasia (HP:0001498)3.31735610
41Horizontal nystagmus (HP:0000666)3.31624192
42Spontaneous abortion (HP:0005268)3.28891650
43Colon cancer (HP:0003003)3.27076957
44Tubulointerstitial nephritis (HP:0001970)3.20099717
45Impulsivity (HP:0100710)3.19312701
46Aplasia/hypoplasia of the humerus (HP:0006507)3.18375362
47Absent thumb (HP:0009777)3.10862107
48Patellar aplasia (HP:0006443)3.09351486
49Abnormality of chromosome stability (HP:0003220)3.06104820
50Meckel diverticulum (HP:0002245)3.05717742
51Neoplasm of striated muscle (HP:0009728)3.03825669
52Abnormal respiratory epithelium morphology (HP:0012253)3.02762663
53Abnormal respiratory motile cilium morphology (HP:0005938)3.02762663
54Infertility (HP:0000789)3.01433401
55Abnormality of the ileum (HP:0001549)2.99914312
56Abnormality of the salivary glands (HP:0010286)2.95265363
57Rib fusion (HP:0000902)2.94431101
58Bruising susceptibility (HP:0000978)2.94399827
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.94068015
60Abnormal spermatogenesis (HP:0008669)2.92338355
61Attenuation of retinal blood vessels (HP:0007843)2.92204731
62Short humerus (HP:0005792)2.91977738
63Abnormal respiratory motile cilium physiology (HP:0012261)2.91296479
64Reticulocytopenia (HP:0001896)2.89177841
65Abdominal situs inversus (HP:0003363)2.87696913
66Abnormality of abdominal situs (HP:0011620)2.87696913
67Shawl scrotum (HP:0000049)2.86023355
68Abnormality of the preputium (HP:0100587)2.84799012
69Upper limb muscle weakness (HP:0003484)2.83643659
70Conjunctival telangiectasia (HP:0000524)2.81112480
71Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.81002186
72Aplasia/Hypoplasia of the patella (HP:0006498)2.80428048
73Paralysis (HP:0003470)2.76843100
74Bony spicule pigmentary retinopathy (HP:0007737)2.73425872
75Missing ribs (HP:0000921)2.68158546
76Rectal fistula (HP:0100590)2.67921162
77Rectovaginal fistula (HP:0000143)2.67921162
78Biliary tract neoplasm (HP:0100574)2.64921452
79Duplicated collecting system (HP:0000081)2.64471685
80Oral leukoplakia (HP:0002745)2.58516634
81Cerebral hypomyelination (HP:0006808)2.57412147
82Esophageal atresia (HP:0002032)2.53505956
83Abnormality of the lower motor neuron (HP:0002366)2.52921893
84Azoospermia (HP:0000027)2.52236056
85Abnormality of lateral ventricle (HP:0030047)2.50760419
86Degeneration of anterior horn cells (HP:0002398)2.47765688
87Abnormality of the anterior horn cell (HP:0006802)2.47765688
88Basal cell carcinoma (HP:0002671)2.47430278
89Hyperkalemia (HP:0002153)2.45747513
90Premature ovarian failure (HP:0008209)2.45383982
91Xanthomatosis (HP:0000991)2.43613580
92Duodenal stenosis (HP:0100867)2.40561096
93Small intestinal stenosis (HP:0012848)2.40561096
94Abnormality of the vasculature of the conjunctiva (HP:0008054)2.38264373
95Menstrual irregularities (HP:0000858)2.37424288
96Abnormal auditory evoked potentials (HP:0006958)2.33993899
97Abnormality of the common coagulation pathway (HP:0010990)2.33983140
98Aplasia/Hypoplasia of the sternum (HP:0006714)2.31263050
99Abnormal pupillary function (HP:0007686)2.29635404
100Intestinal fistula (HP:0100819)2.28553025
101Stenosis of the external auditory canal (HP:0000402)2.25961860
102Abnormal number of incisors (HP:0011064)2.24184285
103Sloping forehead (HP:0000340)2.23870247
104Generalized aminoaciduria (HP:0002909)2.23863567
105Myelodysplasia (HP:0002863)2.23602510
106Papillary thyroid carcinoma (HP:0002895)2.22640546
107Scotoma (HP:0000575)2.21975324
108Neoplasm of the pancreas (HP:0002894)2.21745842
109Horseshoe kidney (HP:0000085)2.20550065
110Tinnitus (HP:0000360)2.19587844
111Truncal obesity (HP:0001956)2.19460058
112Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.19449586
113Vaginal fistula (HP:0004320)2.18552776
114Rough bone trabeculation (HP:0100670)2.17052488
115Abnormality of the renal collecting system (HP:0004742)2.16438084
116Facial hemangioma (HP:0000329)2.13355696
117Abnormal sex determination (HP:0012244)2.13119229
118Sex reversal (HP:0012245)2.13119229
119Abnormality of the hepatic vasculature (HP:0006707)2.12774699
120Abnormality of the duodenum (HP:0002246)2.12441051
121Tracheoesophageal fistula (HP:0002575)2.12247687
122Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.12126231
123Ectopic kidney (HP:0000086)2.10333842
124Amaurosis fugax (HP:0100576)2.09657989
125Abnormality of pyrimidine metabolism (HP:0004353)2.09579699
126Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08195273
127Abnormality of alanine metabolism (HP:0010916)2.08195273
128Hyperalaninemia (HP:0003348)2.08195273
129Hypophosphatemic rickets (HP:0004912)2.06450595
130Cafe-au-lait spot (HP:0000957)2.05377446
131Cortical dysplasia (HP:0002539)2.04717647
132Increased density of long bones (HP:0006392)2.04112669
133Atonic seizures (HP:0010819)2.03784036
134Abnormality of macular pigmentation (HP:0008002)2.02669961
135Vertebral clefting (HP:0008428)2.02565782
136Gastrointestinal atresia (HP:0002589)2.02189948
137Ovarian neoplasm (HP:0100615)2.00747277
138Abnormality of the heme biosynthetic pathway (HP:0010472)2.00562907
139Adenoma sebaceum (HP:0009720)2.00351274
140Angiofibromas (HP:0010615)2.00351274
141Bone marrow hypocellularity (HP:0005528)2.00203412
142Gastrointestinal carcinoma (HP:0002672)2.00166613
143Malignant gastrointestinal tract tumors (HP:0006749)2.00166613
144Supernumerary bones of the axial skeleton (HP:0009144)1.99831502
145Nephroblastoma (Wilms tumor) (HP:0002667)1.97859412
146Asplenia (HP:0001746)1.97706208
147Postural instability (HP:0002172)1.97042855
148Joint hemorrhage (HP:0005261)1.96750270
149Delayed puberty (HP:0000823)1.96715561
150Bladder carcinoma (HP:0002862)1.96284633
151Bladder neoplasm (HP:0009725)1.96284633
152Portal hypertension (HP:0001409)1.96064394
153Breast aplasia (HP:0100783)1.95503117
154Spinal muscular atrophy (HP:0007269)1.94891456
155Fused cervical vertebrae (HP:0002949)1.94689963
156Tongue fasciculations (HP:0001308)1.94493784
157Hyperthyroidism (HP:0000836)1.93661914
158Metaphyseal cupping (HP:0003021)1.93606379
159Central scotoma (HP:0000603)1.93556749
160Supernumerary ribs (HP:0005815)1.93488158
161Abnormal rod and cone electroretinograms (HP:0008323)1.92982492
162Abnormality of the prostate (HP:0008775)1.92562360
163Neoplasm of the colon (HP:0100273)1.91813049
164Triphalangeal thumb (HP:0001199)1.91764356
165Trismus (HP:0000211)1.91394418
166Premature graying of hair (HP:0002216)1.90289204
167Atrophy/Degeneration involving motor neurons (HP:0007373)1.89468126
168Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89217173
169Short thumb (HP:0009778)1.88630902
170Abnormality of cochlea (HP:0000375)1.87614147
171Rimmed vacuoles (HP:0003805)1.84249047
172Intellectual disability, profound (HP:0002187)1.81806905
173Resting tremor (HP:0002322)1.79771579
174Rhinitis (HP:0012384)1.79324666
175Progressive cerebellar ataxia (HP:0002073)1.77990462
176Congenital sensorineural hearing impairment (HP:0008527)1.77133018
177Impaired vibratory sensation (HP:0002495)1.75545017
178Leiomyosarcoma (HP:0100243)1.75282569
179Uterine leiomyosarcoma (HP:0002891)1.75282569
180Clumsiness (HP:0002312)1.72301530
181Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.72265993
182Degeneration of the lateral corticospinal tracts (HP:0002314)1.72265993
183Hypoplastic iliac wings (HP:0002866)1.69263181
184Ventricular fibrillation (HP:0001663)1.67841956
185Abnormality of the costochondral junction (HP:0000919)1.64369552
186Nasal polyposis (HP:0100582)1.63206484
187Osteomalacia (HP:0002749)1.61593802
188Impaired vibration sensation in the lower limbs (HP:0002166)1.60402359
189Cone-rod dystrophy (HP:0000548)1.57519051
190Shoulder girdle muscle weakness (HP:0003547)1.56954039
1913-Methylglutaconic aciduria (HP:0003535)1.56357302
192Transitional cell carcinoma of the bladder (HP:0006740)1.55402254
193Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.55227981
194Stomatitis (HP:0010280)1.54670637
195Optic nerve hypoplasia (HP:0000609)1.54650590
196Thyroid-stimulating hormone excess (HP:0002925)1.53579338
197Urinary bladder sphincter dysfunction (HP:0002839)1.53209756
198Chronic hepatic failure (HP:0100626)1.52148575
199Abolished electroretinogram (ERG) (HP:0000550)1.48596770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.55673612
2CDK123.87687477
3CDC73.81418241
4CAMK1G3.78803711
5PTK2B3.70031598
6BUB13.45468383
7TTK3.40184452
8NEK13.21933268
9RIPK42.97488327
10CSF1R2.96557672
11EPHA22.93788207
12PLK22.86066088
13PIK3CG2.69611403
14RPS6KB22.45182133
15NEK22.40840957
16TAOK32.34502813
17PLK12.33113738
18TAOK22.32122412
19TEC2.30483825
20EIF2AK12.30217678
21AKT32.15843741
22SRPK12.12133005
23PNCK2.06307298
24CDK72.03740562
25FGR2.02043248
26MYLK1.94698234
27ACVR1B1.89871641
28BTK1.83641183
29TSSK61.82084022
30CHEK21.81406736
31ATR1.74099623
32MAPKAPK31.68651038
33PLK41.67968868
34CDK191.62452882
35PASK1.56905502
36PLK31.55924283
37TESK21.54822444
38CHEK11.49614475
39AURKB1.45785839
40EIF2AK31.42756751
41FRK1.42166813
42DYRK31.41840613
43PDK31.34769680
44PDK41.34769680
45BRD41.33935176
46AURKA1.33203773
47PDK21.31970408
48ADRBK21.30916539
49TLK11.30290883
50OXSR11.29556767
51MAP3K81.28463724
52ALK1.27024179
53SYK1.26817644
54STK38L1.18708715
55NUAK11.18547528
56CDK41.16910640
57VRK11.16535542
58STK101.16218125
59BRSK21.16066354
60ATM1.15999634
61PAK41.15034381
62INSRR1.13956940
63PDK11.13445238
64STK41.10102625
65MUSK1.08717720
66CDK21.08123577
67LATS21.06749770
68PDGFRB1.06205216
69PDPK11.04706537
70MET1.04185315
71MAP4K21.02133215
72CAMK1D1.00299437
73RET0.96062974
74BMPR20.95843306
75PRKCI0.95025563
76FLT30.93146528
77MAP3K50.91758550
78SCYL20.90222186
79MKNK20.84139626
80ZAK0.83480688
81TNK20.83197321
82PBK0.81389293
83CSNK2A20.80724271
84BMPR1B0.79688237
85MKNK10.78942330
86GRK50.78649269
87CDK10.77654127
88PIM10.77124832
89HCK0.75813987
90CDK60.74418053
91CAMK10.74191944
92ICK0.73991542
93STK240.73510351
94TYRO30.72684839
95MTOR0.72354965
96CSNK1E0.71006651
97MELK0.70543850
98CSNK1D0.70120300
99IKBKB0.69710001
100ZAP700.68948665
101DYRK20.66667060
102MST40.65990033
103GRK60.65217547
104PRKG10.64572308
105NME20.64364253
106MAP2K10.62795770
107ITK0.61831683
108EEF2K0.60630214
109BRSK10.59665318
110STK160.58710466
111CSNK2A10.58351731
112TAF10.56313641
113BRAF0.56036773
114ADRBK10.54555799
115PAK10.54042296
116ILK0.52882945
117TXK0.51690799
118SGK20.50363995
119LATS10.49819363
120TGFBR10.49628661
121PRKDC0.49543317
122MAP3K90.48287845
123YES10.46696017
124BCKDK0.46678912
125TESK10.46098355
126MARK30.45448573
127MAP2K60.45382802
128ROCK10.43210486
129LMTK20.41972343
130LYN0.40994651
131MAPK140.40869728
132RPS6KA40.40672381
133PKN20.39188339
134PINK10.38931416
135STK30.37660126
136ERBB40.37500329
137EIF2AK20.37369846
138GSK3B0.37078558
139IGF1R0.37030059
140STK380.35297122
141AKT20.34148910
142DAPK10.32480323
143MATK0.32054148
144RPS6KA50.31980316
145BLK0.31852369
146MAPK10.31739560
147IRAK10.31558570
148WNK30.31189129
149DDR20.30308695
150PRKACG0.30080308
151MAPK100.29297715
152MAP3K60.29219759
153JAK20.27053033
154MAPK130.25969502
155SGK10.25656043
156AKT10.25634940
157PRKD10.24914951
158DYRK1B0.24369538
159CDK30.24337818
160MST1R0.23420923
161PRKCB0.23371719
162BMX0.23332657
163MAP3K20.22625199
164EPHB20.21994327
165PRKCG0.21024029
166NEK60.20412906
167WNK10.19318363
168ERBB20.18896978
169FER0.18415136
170DAPK30.18183950
171GRK10.17484847
172NEK90.16988160
173PKN10.16273185
174SIK20.16001193
175PRKG20.15822444
176SGK2230.14237833
177SGK4940.14237833
178PRKCA0.13963333

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.95137186
2DNA replication_Homo sapiens_hsa030304.75793629
3Platelet activation_Homo sapiens_hsa046114.45374049
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.40200324
5RNA transport_Homo sapiens_hsa030133.46877198
6One carbon pool by folate_Homo sapiens_hsa006703.30017004
7Spliceosome_Homo sapiens_hsa030403.17361578
8Fatty acid biosynthesis_Homo sapiens_hsa000613.10483856
9Homologous recombination_Homo sapiens_hsa034403.04513584
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.04413316
11Nucleotide excision repair_Homo sapiens_hsa034202.99059821
12RNA polymerase_Homo sapiens_hsa030202.92787604
13Base excision repair_Homo sapiens_hsa034102.78353037
14Ribosome_Homo sapiens_hsa030102.78014235
15Fanconi anemia pathway_Homo sapiens_hsa034602.69446428
16Cell cycle_Homo sapiens_hsa041102.62965772
17Non-homologous end-joining_Homo sapiens_hsa034502.40136587
18Dorso-ventral axis formation_Homo sapiens_hsa043202.34367496
19Basal transcription factors_Homo sapiens_hsa030222.29320036
20Proteasome_Homo sapiens_hsa030502.28497805
21Olfactory transduction_Homo sapiens_hsa047402.20750585
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.09102265
23ECM-receptor interaction_Homo sapiens_hsa045122.05867659
24Pyrimidine metabolism_Homo sapiens_hsa002402.03893778
25mRNA surveillance pathway_Homo sapiens_hsa030152.01467314
26RNA degradation_Homo sapiens_hsa030181.93786495
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.89306157
28Hematopoietic cell lineage_Homo sapiens_hsa046401.71057755
29p53 signaling pathway_Homo sapiens_hsa041151.64919103
30Chemokine signaling pathway_Homo sapiens_hsa040621.61340215
31Serotonergic synapse_Homo sapiens_hsa047261.58653063
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.55876884
33Glycerolipid metabolism_Homo sapiens_hsa005611.49243945
34Biosynthesis of amino acids_Homo sapiens_hsa012301.38894883
35Gap junction_Homo sapiens_hsa045401.38351648
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34711232
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32567536
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23581814
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.20379919
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18490579
41Selenocompound metabolism_Homo sapiens_hsa004501.14346848
42Pancreatic secretion_Homo sapiens_hsa049721.13988136
43Endocytosis_Homo sapiens_hsa041441.12163853
44Oocyte meiosis_Homo sapiens_hsa041141.12010123
45Glycerophospholipid metabolism_Homo sapiens_hsa005641.10842324
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08441190
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.08100382
48Morphine addiction_Homo sapiens_hsa050321.06312663
49Choline metabolism in cancer_Homo sapiens_hsa052311.05885610
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05818318
51Purine metabolism_Homo sapiens_hsa002301.05396588
52Calcium signaling pathway_Homo sapiens_hsa040201.04106785
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02258419
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02125015
55Primary bile acid biosynthesis_Homo sapiens_hsa001201.01893893
56Phospholipase D signaling pathway_Homo sapiens_hsa040721.01252675
57Systemic lupus erythematosus_Homo sapiens_hsa053221.00747823
58Regulation of autophagy_Homo sapiens_hsa041400.99761596
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98809944
60Epstein-Barr virus infection_Homo sapiens_hsa051690.97386514
61Long-term depression_Homo sapiens_hsa047300.97155567
62Folate biosynthesis_Homo sapiens_hsa007900.97005221
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93878296
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90584279
65B cell receptor signaling pathway_Homo sapiens_hsa046620.89575300
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89406860
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.89326082
68Circadian entrainment_Homo sapiens_hsa047130.87831935
69Viral carcinogenesis_Homo sapiens_hsa052030.86214679
70Collecting duct acid secretion_Homo sapiens_hsa049660.86162378
71ABC transporters_Homo sapiens_hsa020100.83868045
72Focal adhesion_Homo sapiens_hsa045100.83360212
73Sphingolipid metabolism_Homo sapiens_hsa006000.82935894
74Fat digestion and absorption_Homo sapiens_hsa049750.81425911
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77690629
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77509714
77Retinol metabolism_Homo sapiens_hsa008300.73711127
78PPAR signaling pathway_Homo sapiens_hsa033200.73156596
79Hippo signaling pathway_Homo sapiens_hsa043900.72490234
80Fructose and mannose metabolism_Homo sapiens_hsa000510.71459481
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71095492
82Carbon metabolism_Homo sapiens_hsa012000.70910815
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.70329318
84Pentose phosphate pathway_Homo sapiens_hsa000300.70021492
85Glutamatergic synapse_Homo sapiens_hsa047240.68910909
86Glutathione metabolism_Homo sapiens_hsa004800.67849453
87Phototransduction_Homo sapiens_hsa047440.67739480
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67515185
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67048751
90T cell receptor signaling pathway_Homo sapiens_hsa046600.65948228
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65708268
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64531117
93Vitamin B6 metabolism_Homo sapiens_hsa007500.64319391
94TGF-beta signaling pathway_Homo sapiens_hsa043500.63724299
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63561129
96MicroRNAs in cancer_Homo sapiens_hsa052060.62888994
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62540697
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.61204978
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60446565
100Rap1 signaling pathway_Homo sapiens_hsa040150.59489519
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59222151
102Basal cell carcinoma_Homo sapiens_hsa052170.58790252
103Taste transduction_Homo sapiens_hsa047420.58430038
104Shigellosis_Homo sapiens_hsa051310.58151433
105Malaria_Homo sapiens_hsa051440.56963861
106Herpes simplex infection_Homo sapiens_hsa051680.56830987
107Thyroid cancer_Homo sapiens_hsa052160.54849707
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54799767
109Ras signaling pathway_Homo sapiens_hsa040140.53698340
110beta-Alanine metabolism_Homo sapiens_hsa004100.53152085
111MAPK signaling pathway_Homo sapiens_hsa040100.53005859
112Type II diabetes mellitus_Homo sapiens_hsa049300.51786785
113GABAergic synapse_Homo sapiens_hsa047270.51706644
114VEGF signaling pathway_Homo sapiens_hsa043700.51386223
115HTLV-I infection_Homo sapiens_hsa051660.51230417
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.50635206
117Huntingtons disease_Homo sapiens_hsa050160.49761272
118Non-small cell lung cancer_Homo sapiens_hsa052230.48409991
119Fatty acid elongation_Homo sapiens_hsa000620.48392355
120Gastric acid secretion_Homo sapiens_hsa049710.48130425
121ErbB signaling pathway_Homo sapiens_hsa040120.47839837
122mTOR signaling pathway_Homo sapiens_hsa041500.46512975
123Notch signaling pathway_Homo sapiens_hsa043300.45711153
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45671261
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.45036319
126Cholinergic synapse_Homo sapiens_hsa047250.43200722
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.43123492
128Osteoclast differentiation_Homo sapiens_hsa043800.42633404
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41883930
130Antigen processing and presentation_Homo sapiens_hsa046120.41619810
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40932802
132Arginine and proline metabolism_Homo sapiens_hsa003300.40417918
133Renin secretion_Homo sapiens_hsa049240.40396530
134Tight junction_Homo sapiens_hsa045300.40322380
135Primary immunodeficiency_Homo sapiens_hsa053400.40031592
136Salivary secretion_Homo sapiens_hsa049700.38878661
137Endometrial cancer_Homo sapiens_hsa052130.38688702
138Hedgehog signaling pathway_Homo sapiens_hsa043400.36827509
139Colorectal cancer_Homo sapiens_hsa052100.36390373
140Adherens junction_Homo sapiens_hsa045200.35424068
141Galactose metabolism_Homo sapiens_hsa000520.33335356
142Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32950035
143Alcoholism_Homo sapiens_hsa050340.32679935
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.32627815
145Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32272172
146Lysine degradation_Homo sapiens_hsa003100.31991181
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31442302
148Linoleic acid metabolism_Homo sapiens_hsa005910.31043265
149Small cell lung cancer_Homo sapiens_hsa052220.30533752
150Bladder cancer_Homo sapiens_hsa052190.28769533
151Pathways in cancer_Homo sapiens_hsa052000.24024934
152HIF-1 signaling pathway_Homo sapiens_hsa040660.19178268
153Sulfur relay system_Homo sapiens_hsa041220.19022685
154Metabolic pathways_Homo sapiens_hsa011000.18193546
155Arachidonic acid metabolism_Homo sapiens_hsa005900.17309190
156alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17083776
157Wnt signaling pathway_Homo sapiens_hsa043100.14588781
158Arginine biosynthesis_Homo sapiens_hsa002200.13858884
159Pyruvate metabolism_Homo sapiens_hsa006200.13432015
160Nitrogen metabolism_Homo sapiens_hsa009100.12463185
161Renin-angiotensin system_Homo sapiens_hsa046140.09042707
162Melanoma_Homo sapiens_hsa052180.08723853
163Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07252648
164Thyroid hormone signaling pathway_Homo sapiens_hsa049190.07038161
165Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.07015158
166Apoptosis_Homo sapiens_hsa042100.07007009
167Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05939796
168Legionellosis_Homo sapiens_hsa051340.05398428
169Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.05148036
170Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.04713055
171Prostate cancer_Homo sapiens_hsa052150.02591454
172Regulation of actin cytoskeleton_Homo sapiens_hsa048100.02293380
173Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.02057459
174Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.01978987
175PI3K-Akt signaling pathway_Homo sapiens_hsa041510.00721424
176Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0213573

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