MORC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein-DNA complex disassembly (GO:0032986)4.03587197
2nucleosome disassembly (GO:0006337)4.03587197
3acrosome reaction (GO:0007340)4.01017349
4regulation of posttranscriptional gene silencing (GO:0060147)3.98643135
5regulation of gene silencing by miRNA (GO:0060964)3.98643135
6regulation of gene silencing by RNA (GO:0060966)3.98643135
7regulation of DNA endoreduplication (GO:0032875)3.96947760
8DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.96111425
9DNA damage response, signal transduction resulting in transcription (GO:0042772)3.84456794
10negative regulation of histone methylation (GO:0031061)3.83506757
11RNA localization (GO:0006403)3.81472289
12interferon-gamma secretion (GO:0072643)3.76284670
13protein polyglutamylation (GO:0018095)3.75764642
14sperm motility (GO:0030317)3.71896698
15positive regulation of synapse maturation (GO:0090129)3.64353077
16binding of sperm to zona pellucida (GO:0007339)3.53510701
17phosphatidylethanolamine biosynthetic process (GO:0006646)3.46945316
18regulation of mesoderm development (GO:2000380)3.28906351
19rRNA methylation (GO:0031167)3.28774967
20regulation of hippo signaling (GO:0035330)3.27078281
21chromatin silencing (GO:0006342)3.26341926
22sulfation (GO:0051923)3.25391046
23phosphatidylethanolamine metabolic process (GO:0046337)3.23404129
24fusion of sperm to egg plasma membrane (GO:0007342)3.20606679
25regulation of glomerulus development (GO:0090192)3.16147843
26membrane repolarization during action potential (GO:0086011)3.13086664
27cell proliferation in forebrain (GO:0021846)3.10745629
28sperm-egg recognition (GO:0035036)3.10096607
29membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.07439537
30artery development (GO:0060840)3.02670765
31rRNA modification (GO:0000154)3.02484264
32DNA methylation involved in gamete generation (GO:0043046)3.00025259
33spermatid development (GO:0007286)2.99920396
34DNA packaging (GO:0006323)2.99820669
35chromosome condensation (GO:0030261)2.99691505
36somite development (GO:0061053)2.96483318
37negative regulation of DNA-templated transcription, elongation (GO:0032785)2.95279387
38regulation of histone H3-K9 methylation (GO:0051570)2.93666766
39regulation of synapse maturation (GO:0090128)2.90750073
40pre-miRNA processing (GO:0031054)2.87678075
41embryonic skeletal joint morphogenesis (GO:0060272)2.87114170
42regulation of chromatin binding (GO:0035561)2.86615955
43negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.83956748
44lung-associated mesenchyme development (GO:0060484)2.82413120
45spinal cord development (GO:0021510)2.79483057
46positive regulation of transcription regulatory region DNA binding (GO:2000679)2.77450837
47male meiosis (GO:0007140)2.74230036
48musculoskeletal movement (GO:0050881)2.73505120
49multicellular organismal movement (GO:0050879)2.73505120
50V(D)J recombination (GO:0033151)2.71394588
51renal system development (GO:0072001)2.65147267
52histone H2A monoubiquitination (GO:0035518)2.64170637
53anterior/posterior axis specification, embryo (GO:0008595)2.63066062
54lateral sprouting from an epithelium (GO:0060601)2.62645362
55nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.62231530
56negative regulation of gene expression, epigenetic (GO:0045814)2.61249044
57negative regulation of translation, ncRNA-mediated (GO:0040033)2.58417520
58regulation of translation, ncRNA-mediated (GO:0045974)2.58417520
59negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.58417520
60embryonic hindlimb morphogenesis (GO:0035116)2.56562303
61negative regulation of Rho protein signal transduction (GO:0035024)2.55337617
62regulation of cell proliferation involved in kidney development (GO:1901722)2.54687170
63DNA alkylation (GO:0006305)2.54240185
64DNA methylation (GO:0006306)2.54240185
65generation of neurons (GO:0048699)2.51347590
66regulation of centriole replication (GO:0046599)2.50356942
67multicellular organism reproduction (GO:0032504)2.48316857
68single strand break repair (GO:0000012)2.47626784
69regulation of stem cell maintenance (GO:2000036)2.47151691
70protein sumoylation (GO:0016925)2.45960763
71heterochromatin organization (GO:0070828)2.45959237
72microtubule depolymerization (GO:0007019)2.45394564
73mesonephros development (GO:0001823)2.44048191
74lung secretory cell differentiation (GO:0061140)2.43531562
75pituitary gland development (GO:0021983)2.42542910
76insulin-like growth factor receptor signaling pathway (GO:0048009)2.41876446
77negative regulation of cardiac muscle tissue development (GO:0055026)2.39256654
78peptidyl-arginine omega-N-methylation (GO:0035247)2.38217342
79regulation of somitogenesis (GO:0014807)2.37686845
80nuclear pore complex assembly (GO:0051292)2.37149834
81regulation of tight junction assembly (GO:2000810)2.36763991
82embryonic foregut morphogenesis (GO:0048617)2.36639709
83negative regulation of gene silencing (GO:0060969)2.36553014
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.33913440
85gene silencing (GO:0016458)2.32889098
86negative regulation of JAK-STAT cascade (GO:0046426)2.32055116
87cell-cell recognition (GO:0009988)2.31442802
88centriole assembly (GO:0098534)2.31387547
89regulation of transcription involved in cell fate commitment (GO:0060850)2.29294239
90plasma membrane fusion (GO:0045026)2.28935337
91synapsis (GO:0007129)2.28875841
92prostate gland growth (GO:0060736)2.28868678
93regulation of translational fidelity (GO:0006450)2.28812871
94histone H3-K9 methylation (GO:0051567)2.28161381
95regulation of translational termination (GO:0006449)2.27868558
96response to UV-C (GO:0010225)2.27387406
97response to pheromone (GO:0019236)2.25876787
98positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.25722998
99limb bud formation (GO:0060174)2.25531012
100regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.25118940

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human5.78066666
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.21015006
3E2F7_22180533_ChIP-Seq_HELA_Human3.54716324
4TP63_19390658_ChIP-ChIP_HaCaT_Human2.95232203
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.78267122
6EZH2_22144423_ChIP-Seq_EOC_Human2.40702456
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36591540
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.34169115
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31451167
10ESR1_15608294_ChIP-ChIP_MCF-7_Human2.18027484
11TDRD3_21172665_ChIP-Seq_MCF-7_Human2.14690408
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06680250
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.02685511
14FUS_26573619_Chip-Seq_HEK293_Human2.00158889
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86151883
16SALL1_21062744_ChIP-ChIP_HESCs_Human1.78143158
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77002131
18PKCTHETA_26484144_Chip-Seq_BREAST_Human1.72272871
19GATA1_26923725_Chip-Seq_HPCs_Mouse1.69949371
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69643995
21CIITA_25753668_ChIP-Seq_RAJI_Human1.67703453
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61289200
23ZNF274_21170338_ChIP-Seq_K562_Hela1.59206061
24ARNT_22903824_ChIP-Seq_MCF-7_Human1.55490163
25AHR_22903824_ChIP-Seq_MCF-7_Human1.54641672
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50983832
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50709536
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49364733
29SOX2_16153702_ChIP-ChIP_HESCs_Human1.46234182
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46105795
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43310043
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.39537628
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38164735
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37891105
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34197014
36POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33611290
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33611290
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32893009
39GBX2_23144817_ChIP-Seq_PC3_Human1.31620211
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31114733
41NANOG_16153702_ChIP-ChIP_HESCs_Human1.30087511
42TP53_20018659_ChIP-ChIP_R1E_Mouse1.28936942
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28185936
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.28072765
45IRF1_19129219_ChIP-ChIP_H3396_Human1.27344959
46IGF1R_20145208_ChIP-Seq_DFB_Human1.27227261
47AR_21572438_ChIP-Seq_LNCaP_Human1.26910659
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25754143
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.24922928
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23623968
51ER_23166858_ChIP-Seq_MCF-7_Human1.19425983
52CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18167316
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.16842966
54* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.16771373
55MYC_18940864_ChIP-ChIP_HL60_Human1.16478088
56RAC3_21632823_ChIP-Seq_H3396_Human1.15410824
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14409456
58ERA_21632823_ChIP-Seq_H3396_Human1.13824354
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13714592
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13605229
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.12855021
62TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12415769
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11528085
64TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11052478
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10342281
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09971055
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09971055
68SOX9_26525672_Chip-Seq_HEART_Mouse1.09864873
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09080593
70P68_20966046_ChIP-Seq_HELA_Human1.09054703
71CBP_20019798_ChIP-Seq_JUKART_Human1.06865594
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06865594
73KDM5A_27292631_Chip-Seq_BREAST_Human1.04900010
74CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04823218
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04537622
76EWS_26573619_Chip-Seq_HEK293_Human1.00855249
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00574533
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00567172
79JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00211187
80FOXP1_21924763_ChIP-Seq_HESCs_Human0.99291966
81TP53_22127205_ChIP-Seq_IMR90_Human0.99086080
82SMAD3_21741376_ChIP-Seq_ESCs_Human0.98685274
83HOXB7_26014856_ChIP-Seq_BT474_Human0.98470890
84FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98435792
85RNF2_27304074_Chip-Seq_NSC_Mouse0.98216978
86MYC_22102868_ChIP-Seq_BL_Human0.97259484
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96140259
88SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95615017
89XRN2_22483619_ChIP-Seq_HELA_Human0.95015183
90EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94840532
91TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.93298607
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93152107
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.90818990
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89559414
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89276352
96RNF2_27304074_Chip-Seq_ESCs_Mouse0.89206716
97EZH2_27294783_Chip-Seq_ESCs_Mouse0.88512045
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88281043
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87916832
100TP53_23651856_ChIP-Seq_MEFs_Mouse0.87724281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization3.67205995
2MP0000537_abnormal_urethra_morphology2.71924119
3MP0000049_abnormal_middle_ear2.63274717
4MP0006292_abnormal_olfactory_placode2.53624277
5MP0003119_abnormal_digestive_system2.33912831
6MP0002160_abnormal_reproductive_system2.30481404
7MP0003937_abnormal_limbs/digits/tail_de2.12066401
8MP0008877_abnormal_DNA_methylation2.02951212
9MP0003567_abnormal_fetal_cardiomyocyte1.94711494
10MP0009053_abnormal_anal_canal1.90201398
11MP0000678_abnormal_parathyroid_gland1.87960343
12MP0002249_abnormal_larynx_morphology1.81083328
13MP0003942_abnormal_urinary_system1.79390155
14MP0003698_abnormal_male_reproductive1.75380035
15MP0001348_abnormal_lacrimal_gland1.73168618
16MP0003890_abnormal_embryonic-extraembry1.71970950
17MP0003693_abnormal_embryo_hatching1.68333889
18MP0003315_abnormal_perineum_morphology1.67487086
19MP0005646_abnormal_pituitary_gland1.66311224
20MP0002089_abnormal_postnatal_growth/wei1.65858326
21MP0003283_abnormal_digestive_organ1.64921895
22MP0001929_abnormal_gametogenesis1.63735206
23MP0003111_abnormal_nucleus_morphology1.59713376
24MP0009250_abnormal_appendicular_skeleto1.55867897
25MP0010094_abnormal_chromosome_stability1.55713856
26MP0004885_abnormal_endolymph1.55673747
27MP0003938_abnormal_ear_development1.53513599
28MP0008058_abnormal_DNA_repair1.53348011
29MP0003718_maternal_effect1.51857077
30MP0000631_abnormal_neuroendocrine_gland1.49940858
31MP0004197_abnormal_fetal_growth/weight/1.45773055
32MP0005389_reproductive_system_phenotype1.43200349
33MP0002084_abnormal_developmental_patter1.40922979
34MP0001485_abnormal_pinna_reflex1.38012960
35MP0002138_abnormal_hepatobiliary_system1.36531205
36MP0000467_abnormal_esophagus_morphology1.34110828
37MP0004134_abnormal_chest_morphology1.33856619
38MP0005394_taste/olfaction_phenotype1.32164422
39MP0005499_abnormal_olfactory_system1.32164422
40MP0002282_abnormal_trachea_morphology1.30004202
41MP0008995_early_reproductive_senescence1.29765147
42MP0000428_abnormal_craniofacial_morphol1.27653498
43MP0002210_abnormal_sex_determination1.26369902
44MP0001661_extended_life_span1.25342877
45MP0003115_abnormal_respiratory_system1.24646563
46MP0003786_premature_aging1.23848305
47MP0004133_heterotaxia1.21761605
48MP0002085_abnormal_embryonic_tissue1.21588238
49MP0001145_abnormal_male_reproductive1.21468785
50MP0003646_muscle_fatigue1.20463207
51MP0002932_abnormal_joint_morphology1.20266751
52MP0003861_abnormal_nervous_system1.19556696
53MP0002116_abnormal_craniofacial_bone1.18797890
54MP0002751_abnormal_autonomic_nervous1.17942218
55MP0003077_abnormal_cell_cycle1.17546980
56MP0000534_abnormal_ureter_morphology1.16981874
57MP0008932_abnormal_embryonic_tissue1.14071010
58MP0000653_abnormal_sex_gland1.12658347
59MP0001293_anophthalmia1.12381892
60MP0008007_abnormal_cellular_replicative1.12150789
61MP0004145_abnormal_muscle_electrophysio1.10781998
62MP0008789_abnormal_olfactory_epithelium1.10743636
63MP0001697_abnormal_embryo_size1.10518101
64MP0004233_abnormal_muscle_weight1.10007338
65MP0002161_abnormal_fertility/fecundity1.08945536
66MP0006072_abnormal_retinal_apoptosis1.05667171
67MP0003936_abnormal_reproductive_system1.05648525
68MP0004859_abnormal_synaptic_plasticity1.05324847
69MP0003935_abnormal_craniofacial_develop1.04497274
70MP0004957_abnormal_blastocyst_morpholog1.01864192
71MP0004264_abnormal_extraembryonic_tissu1.01118288
72MP0002114_abnormal_axial_skeleton1.00047663
73MP0003755_abnormal_palate_morphology0.99253894
74MP0008770_decreased_survivor_rate0.99141584
75MP0002081_perinatal_lethality0.97682707
76MP0002108_abnormal_muscle_morphology0.97566988
77MP0000613_abnormal_salivary_gland0.96993807
78MP0002184_abnormal_innervation0.96447540
79MP0003385_abnormal_body_wall0.91916958
80MP0002102_abnormal_ear_morphology0.91816611
81MP0005380_embryogenesis_phenotype0.90480065
82MP0001672_abnormal_embryogenesis/_devel0.90480065
83MP0001286_abnormal_eye_development0.89854884
84MP0009697_abnormal_copulation0.89044633
85MP0005377_hearing/vestibular/ear_phenot0.88781043
86MP0003878_abnormal_ear_physiology0.88781043
87MP0005670_abnormal_white_adipose0.88777494
88MP0009780_abnormal_chondrocyte_physiolo0.87923466
89MP0009384_cardiac_valve_regurgitation0.86837818
90MP0001340_abnormal_eyelid_morphology0.86632131
91MP0002080_prenatal_lethality0.86083192
92MP0001730_embryonic_growth_arrest0.85939843
93MP0005076_abnormal_cell_differentiation0.84770008
94MP0002086_abnormal_extraembryonic_tissu0.84748879
95MP0002111_abnormal_tail_morphology0.84292739
96MP0001919_abnormal_reproductive_system0.81666689
97MP0009672_abnormal_birth_weight0.79621079
98MP0004185_abnormal_adipocyte_glucose0.78787427
99MP0002254_reproductive_system_inflammat0.77665459
100MP0002697_abnormal_eye_size0.77124908

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the proximal phalanges of the hand (HP:0009834)4.16441563
2Pendular nystagmus (HP:0012043)3.64145371
3Morphological abnormality of the middle ear (HP:0008609)3.52779104
4Abnormality of the nasal septum (HP:0000419)3.41360986
5Severe visual impairment (HP:0001141)3.35529682
6Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.19323839
7Short 1st metacarpal (HP:0010034)3.19323839
8Fibular aplasia (HP:0002990)3.14599529
9Abnormality of the middle phalanges of the toes (HP:0010183)3.01001177
10Genetic anticipation (HP:0003743)2.87355177
11Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84490980
12Abnormality of the ileum (HP:0001549)2.81650635
13Aplasia/Hypoplasia of the sternum (HP:0006714)2.78259809
14Aplasia/Hypoplasia of the uvula (HP:0010293)2.78121716
15Meckel diverticulum (HP:0002245)2.76184057
16Abnormality of the columella (HP:0009929)2.73906772
17Synostosis of carpal bones (HP:0005048)2.71004920
18Abnormality of the 1st metacarpal (HP:0010009)2.69115693
19Persistence of primary teeth (HP:0006335)2.60805918
20Hamartoma of the eye (HP:0010568)2.60401320
21Chromsome breakage (HP:0040012)2.59978334
22Hypoplasia of the uterus (HP:0000013)2.57174904
23Abnormality of DNA repair (HP:0003254)2.55875589
24Aplasia/Hypoplasia of the patella (HP:0006498)2.51719874
25Abnormal number of incisors (HP:0011064)2.47132510
26Short femoral neck (HP:0100864)2.40928756
27Conjunctival hamartoma (HP:0100780)2.40809101
28Hypoplastic pelvis (HP:0008839)2.40215909
29High anterior hairline (HP:0009890)2.39560724
30Keratoconus (HP:0000563)2.38877965
31Increased corneal curvature (HP:0100692)2.38877965
32Clumsiness (HP:0002312)2.32413551
33Patellar aplasia (HP:0006443)2.32338712
34Abnormality of the preputium (HP:0100587)2.29869579
35Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.27659571
36Aplasia/Hypoplasia of the fibula (HP:0006492)2.26445636
37Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.25587105
38Short hallux (HP:0010109)2.23023311
39Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.19251987
40Short 4th metacarpal (HP:0010044)2.19251987
41Meningioma (HP:0002858)2.18084998
42Abnormality of the carotid arteries (HP:0005344)2.17349560
43Bilateral microphthalmos (HP:0007633)2.16512810
44Aplasia/hypoplasia of the uterus (HP:0008684)2.12584763
45Abnormality of chromosome stability (HP:0003220)2.12315483
46Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.09119675
47Short phalanx of the thumb (HP:0009660)2.08539887
48Abolished electroretinogram (ERG) (HP:0000550)2.06807543
49Squamous cell carcinoma (HP:0002860)2.06749339
50Oligodontia (HP:0000677)2.05607306
51Broad hallux (HP:0010055)2.05115873
52Aplasia/Hypoplasia of the hallux (HP:0008362)2.04167701
53Progressive cerebellar ataxia (HP:0002073)2.03399670
54Carpal synostosis (HP:0009702)2.01698615
55Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.01542039
56Resting tremor (HP:0002322)1.98589849
57Osteomalacia (HP:0002749)1.93475675
58Abnormality of the phalanges of the 5th finger (HP:0004213)1.92300995
59Abnormality of the aortic arch (HP:0012303)1.91359589
60Mesomelia (HP:0003027)1.91222682
61Aplasia involving bones of the upper limbs (HP:0009823)1.89890290
62Aplasia of the phalanges of the hand (HP:0009802)1.89890290
63Aplasia involving bones of the extremities (HP:0009825)1.89890290
64Small hand (HP:0200055)1.89157915
65Broad toe (HP:0001837)1.88475214
66Bony spicule pigmentary retinopathy (HP:0007737)1.85959594
67Abnormality of cochlea (HP:0000375)1.84185072
68Absent thumb (HP:0009777)1.84109538
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84056964
70Ependymoma (HP:0002888)1.82943454
71Megalencephaly (HP:0001355)1.82386581
72Angiofibromas (HP:0010615)1.81178255
73Adenoma sebaceum (HP:0009720)1.81178255
74Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79746280
75Duodenal stenosis (HP:0100867)1.79094450
76Small intestinal stenosis (HP:0012848)1.79094450
77Optic nerve hypoplasia (HP:0000609)1.76926784
78Ectopic kidney (HP:0000086)1.76719695
79Homocystinuria (HP:0002156)1.76108118
80Abnormality of homocysteine metabolism (HP:0010919)1.76108118
81Radial bowing (HP:0002986)1.75919711
82Vitreoretinal degeneration (HP:0000655)1.75600126
83Adactyly (HP:0009776)1.73957232
842-3 toe syndactyly (HP:0004691)1.72072331
85Nephronophthisis (HP:0000090)1.72058248
86Synostosis involving the elbow (HP:0003938)1.71801575
87Humeroradial synostosis (HP:0003041)1.71801575
88Carpal bone hypoplasia (HP:0001498)1.71799523
89Myelomeningocele (HP:0002475)1.70807243
90Symphalangism affecting the phalanges of the hand (HP:0009773)1.70765065
91Preauricular pit (HP:0004467)1.70440796
92Periauricular skin pits (HP:0100277)1.70440796
93Abnormality of the renal collecting system (HP:0004742)1.70039108
94Aplasia/hypoplasia of the humerus (HP:0006507)1.69657885
95Facial asymmetry (HP:0000324)1.67118051
96Fused cervical vertebrae (HP:0002949)1.66895891
97Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.66866856
98Enlarged kidneys (HP:0000105)1.65676689
99Benign neoplasm of the central nervous system (HP:0100835)1.65013552
100Abnormality of the phalanges of the 2nd finger (HP:0009541)1.62309356

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.19913497
2LATS13.46158231
3PLK42.90329880
4PINK12.79661508
5SMG12.49344183
6TAF12.20276154
7PKN22.01770258
8BRD41.99984806
9CDC71.91546886
10ICK1.77931986
11SRPK11.73617114
12TRIB31.71955798
13STK38L1.67656752
14STK381.64017939
15LATS21.62857287
16NUAK11.61085660
17MAP2K21.60530047
18TNIK1.59543032
19CDK71.55916970
20CAMK1G1.51880143
21PRKD31.50767604
22VRK21.50051082
23CDK91.45557245
24MAP3K101.44353484
25FGFR21.44351292
26PRKD21.32431346
27NEK21.28443673
28TTK1.27303360
29MAP3K91.27048192
30SIK21.26956066
31PLK21.26282276
32CAMK1D1.24073861
33CASK1.23272828
34RPS6KA21.21002227
35FGFR41.19840325
36BMPR1B1.18348761
37ATR1.17741034
38SIK11.16109505
39MTOR1.14184272
40INSRR1.12197133
41MAPKAPK31.10746654
42MAP4K21.07322660
43MUSK1.04491855
44TSSK61.04425756
45CSNK1A1L1.03759175
46EEF2K1.01947917
47SGK4941.01666850
48SGK2231.01666850
49WNK11.00957414
50DYRK30.99914754
51GRK10.99913004
52RPS6KA60.93775426
53RPS6KC10.93690063
54RPS6KL10.93690063
55CHEK10.92393070
56NME10.91891641
57ZAK0.88945447
58DYRK20.83021312
59SGK20.81339554
60AURKA0.79659010
61CDK20.76165322
62SGK30.75541867
63RPS6KA10.73885516
64PRKAA10.73883446
65CDK10.73565585
66CDK80.71858159
67CSNK1G30.70911725
68PNCK0.70483236
69GSK3B0.68620865
70CDK40.65419284
71MARK30.65238166
72ATM0.65233737
73MAPK90.64615575
74PLK10.63338219
75CSNK1G10.61374858
76DDR20.61320333
77CDK30.60299574
78MAPK80.57156963
79MELK0.56305112
80EPHA20.55989253
81CHEK20.55676421
82TIE10.54339046
83CSNK1G20.54028573
84TYRO30.53142887
85TAOK30.53132350
86CSNK1D0.50846843
87FLT30.50637798
88MAPK10.50578027
89MAP2K10.49089818
90CSNK1E0.48395259
91NLK0.48284940
92FGFR10.48263306
93MAPK140.47278788
94BUB10.44496770
95RPS6KB10.44448783
96PAK20.44252690
97MKNK20.43166985
98PLK30.42987841
99GRK60.42511675
100TRIM280.42371228

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71640705
2Selenocompound metabolism_Homo sapiens_hsa004502.62974480
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.31459510
4RNA transport_Homo sapiens_hsa030132.21434692
5Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.19853462
6Hedgehog signaling pathway_Homo sapiens_hsa043402.05479070
7Fanconi anemia pathway_Homo sapiens_hsa034601.96915734
8Spliceosome_Homo sapiens_hsa030401.95846327
9One carbon pool by folate_Homo sapiens_hsa006701.93633979
10Fatty acid biosynthesis_Homo sapiens_hsa000611.90776113
11mRNA surveillance pathway_Homo sapiens_hsa030151.87170179
12DNA replication_Homo sapiens_hsa030301.77961799
13Nicotine addiction_Homo sapiens_hsa050331.76798062
14Basal transcription factors_Homo sapiens_hsa030221.63464112
15Basal cell carcinoma_Homo sapiens_hsa052171.62464909
16Homologous recombination_Homo sapiens_hsa034401.55691760
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53866795
18Olfactory transduction_Homo sapiens_hsa047401.48136950
19Wnt signaling pathway_Homo sapiens_hsa043101.44830130
20RNA degradation_Homo sapiens_hsa030181.40920264
21Hippo signaling pathway_Homo sapiens_hsa043901.38455997
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.36923861
23Phototransduction_Homo sapiens_hsa047441.34524790
24Lysine degradation_Homo sapiens_hsa003101.34063239
25Taste transduction_Homo sapiens_hsa047421.32789675
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31398788
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30916821
28Oocyte meiosis_Homo sapiens_hsa041141.30633749
29RNA polymerase_Homo sapiens_hsa030201.30527738
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.30398847
31Sulfur relay system_Homo sapiens_hsa041221.29549776
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28522828
33Cell cycle_Homo sapiens_hsa041101.26626581
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21613720
35Adherens junction_Homo sapiens_hsa045201.21447185
36Non-homologous end-joining_Homo sapiens_hsa034501.20317049
37Melanoma_Homo sapiens_hsa052181.17604759
38Dorso-ventral axis formation_Homo sapiens_hsa043201.13706346
39Nucleotide excision repair_Homo sapiens_hsa034201.12922971
40Vitamin digestion and absorption_Homo sapiens_hsa049771.09150501
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07884697
42Type II diabetes mellitus_Homo sapiens_hsa049301.07566962
43MicroRNAs in cancer_Homo sapiens_hsa052061.06004816
44Gap junction_Homo sapiens_hsa045401.03596875
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02585555
46Thyroid cancer_Homo sapiens_hsa052160.98393204
47Morphine addiction_Homo sapiens_hsa050320.97406341
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96220438
49TGF-beta signaling pathway_Homo sapiens_hsa043500.96095932
50mTOR signaling pathway_Homo sapiens_hsa041500.94921592
51Prostate cancer_Homo sapiens_hsa052150.93197519
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87587869
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85410585
54Mismatch repair_Homo sapiens_hsa034300.84743514
55Biosynthesis of amino acids_Homo sapiens_hsa012300.82712564
56Base excision repair_Homo sapiens_hsa034100.82433531
57Tight junction_Homo sapiens_hsa045300.81431992
58Axon guidance_Homo sapiens_hsa043600.79774611
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79303925
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.78927703
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75342305
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72959938
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71159034
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71103361
65Cholinergic synapse_Homo sapiens_hsa047250.69867742
66Endometrial cancer_Homo sapiens_hsa052130.68876110
67Gastric acid secretion_Homo sapiens_hsa049710.68854061
68Purine metabolism_Homo sapiens_hsa002300.66087478
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65164812
70Circadian entrainment_Homo sapiens_hsa047130.63507849
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.63005360
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62224483
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60567742
74Glutamatergic synapse_Homo sapiens_hsa047240.60049021
75Insulin resistance_Homo sapiens_hsa049310.58735640
76Renin secretion_Homo sapiens_hsa049240.56203619
77AMPK signaling pathway_Homo sapiens_hsa041520.55008487
78MAPK signaling pathway_Homo sapiens_hsa040100.52479137
79Pyrimidine metabolism_Homo sapiens_hsa002400.51800416
80GABAergic synapse_Homo sapiens_hsa047270.51123483
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.49958724
82Melanogenesis_Homo sapiens_hsa049160.49913155
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47292158
84Circadian rhythm_Homo sapiens_hsa047100.47247026
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47131053
86Choline metabolism in cancer_Homo sapiens_hsa052310.46924709
87Oxytocin signaling pathway_Homo sapiens_hsa049210.46640743
88Notch signaling pathway_Homo sapiens_hsa043300.46080410
89p53 signaling pathway_Homo sapiens_hsa041150.44501160
90Glycerolipid metabolism_Homo sapiens_hsa005610.44080481
91N-Glycan biosynthesis_Homo sapiens_hsa005100.43739462
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.43191522
93Estrogen signaling pathway_Homo sapiens_hsa049150.42976496
94Glioma_Homo sapiens_hsa052140.42493157
95Dilated cardiomyopathy_Homo sapiens_hsa054140.41778849
96Glucagon signaling pathway_Homo sapiens_hsa049220.40554813
97Calcium signaling pathway_Homo sapiens_hsa040200.38815485
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38598628
99Prolactin signaling pathway_Homo sapiens_hsa049170.37705815
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36542756

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