MORC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)8.18509914
2doxorubicin metabolic process (GO:0044598)8.18509914
3daunorubicin metabolic process (GO:0044597)8.18509914
4protein localization to kinetochore (GO:0034501)6.55471874
5positive regulation of gamma-delta T cell activation (GO:0046645)5.95168836
6regulation of nuclear cell cycle DNA replication (GO:0033262)5.76121614
7negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.34242518
8nuclear pore complex assembly (GO:0051292)5.32805924
9regulation of telomere maintenance via telomerase (GO:0032210)5.15438136
10aminoglycoside antibiotic metabolic process (GO:0030647)5.09260492
11negative regulation of cell cycle G2/M phase transition (GO:1902750)5.00916912
12protein localization to chromosome, centromeric region (GO:0071459)5.00434388
13regulation of mammary gland epithelial cell proliferation (GO:0033599)4.97450536
14regulation of B cell receptor signaling pathway (GO:0050855)4.95553600
15nuclear pore organization (GO:0006999)4.85539697
16mitotic sister chromatid segregation (GO:0000070)4.84512356
17negative regulation of cell killing (GO:0031342)4.77982836
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.77982836
19histone H4-K12 acetylation (GO:0043983)4.62457092
20histone H4-K5 acetylation (GO:0043981)4.61920982
21histone H4-K8 acetylation (GO:0043982)4.61920982
22DNA replication-dependent nucleosome assembly (GO:0006335)4.59293058
23DNA replication-dependent nucleosome organization (GO:0034723)4.59293058
24positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.55957204
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.55327613
26negative regulation of telomerase activity (GO:0051974)4.48650753
27negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.47898360
28DNA replication checkpoint (GO:0000076)4.47398166
29heterochromatin organization (GO:0070828)4.38774045
30negative regulation of epidermis development (GO:0045683)4.34828911
31regulation of gamma-delta T cell activation (GO:0046643)4.32025123
32rRNA transcription (GO:0009303)4.30766207
33pore complex assembly (GO:0046931)4.29878740
34detection of molecule of bacterial origin (GO:0032490)4.29682760
35sister chromatid segregation (GO:0000819)4.29295807
36somite rostral/caudal axis specification (GO:0032525)4.28662325
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.21051076
38positive regulation by organism of defense response of other organism involved in symbiotic interact4.21051076
39modulation by symbiont of host immune response (GO:0052553)4.21051076
40positive regulation by symbiont of host defense response (GO:0052509)4.21051076
41modulation by symbiont of host defense response (GO:0052031)4.21051076
42modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.21051076
43interferon-gamma production (GO:0032609)4.19871161
44neutrophil activation involved in immune response (GO:0002283)4.19624024
45microglial cell activation (GO:0001774)4.18258509
46positive regulation of DNA-dependent DNA replication (GO:2000105)4.17902519
47chromatin assembly (GO:0031497)4.14277097
48regulation of gamma-delta T cell differentiation (GO:0045586)4.14269878
49cellular extravasation (GO:0045123)4.12535998
50regulation of MHC class I biosynthetic process (GO:0045343)4.11907836
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.03634981
52regulation of translation in response to stress (GO:0043555)3.93720350
53phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.92044208
54regulation of response to osmotic stress (GO:0047484)3.90699814
55hepatocyte apoptotic process (GO:0097284)3.87914134
56macrophage activation involved in immune response (GO:0002281)3.85065293
57muscle organ morphogenesis (GO:0048644)3.84347668
58negative regulation of T cell mediated immunity (GO:0002710)3.76221032
59regulation of interferon-beta biosynthetic process (GO:0045357)3.73520116
60positive regulation of granulocyte differentiation (GO:0030854)3.73456011
61negative regulation of telomere maintenance (GO:0032205)3.72405628
62mitotic chromosome condensation (GO:0007076)3.71767068
63DNA duplex unwinding (GO:0032508)3.71695757
64DNA geometric change (GO:0032392)3.70647960
65negative T cell selection (GO:0043383)3.67754751
66rRNA methylation (GO:0031167)3.66323722
67negative regulation of interleukin-12 production (GO:0032695)3.64631489
68negative thymic T cell selection (GO:0045060)3.63288064
69histone H3-K36 demethylation (GO:0070544)3.62547976
70neutrophil mediated immunity (GO:0002446)3.61583494
71DNA unwinding involved in DNA replication (GO:0006268)3.57188117
72cellular response to ethanol (GO:0071361)3.55824669
73histone H4-K16 acetylation (GO:0043984)3.52276667
74macrophage activation (GO:0042116)3.51801489
75detection of other organism (GO:0098543)3.48216957
76cytidine catabolic process (GO:0006216)3.46404913
77cytidine deamination (GO:0009972)3.46404913
78cytidine metabolic process (GO:0046087)3.46404913
79negative regulation of epidermal cell differentiation (GO:0045605)3.46280861
80* maintenance of protein location in nucleus (GO:0051457)3.44806812
81detection of external biotic stimulus (GO:0098581)3.44254072
82rRNA modification (GO:0000154)3.43752567
83response to interleukin-15 (GO:0070672)3.43083930
84B cell receptor signaling pathway (GO:0050853)3.42451925
85intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.35434523
86negative regulation of lymphocyte mediated immunity (GO:0002707)3.34261589
87histone mRNA catabolic process (GO:0071044)3.31483667
88pre-miRNA processing (GO:0031054)3.29014910
89positive T cell selection (GO:0043368)3.28485629
90mRNA stabilization (GO:0048255)3.28403874
91RNA stabilization (GO:0043489)3.28403874
92positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.26820615
93DNA replication initiation (GO:0006270)3.26288165
94notochord development (GO:0030903)3.26068511
95regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.25513220
96protein K11-linked deubiquitination (GO:0035871)3.21053977
97myeloid leukocyte mediated immunity (GO:0002444)3.21001718
98regulation of gene silencing by RNA (GO:0060966)3.20808911
99regulation of posttranscriptional gene silencing (GO:0060147)3.20808911
100regulation of gene silencing by miRNA (GO:0060964)3.20808911
101regulation of telomere maintenance (GO:0032204)3.19938331
102neutrophil activation (GO:0042119)3.19819295
103ribosome biogenesis (GO:0042254)3.18541423
104myeloid cell activation involved in immune response (GO:0002275)3.18359191
105negative regulation of T-helper cell differentiation (GO:0045623)3.15408863
106negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.15408863
107formation of translation preinitiation complex (GO:0001731)3.14963634
108regulation of double-strand break repair (GO:2000779)3.14840098
109positive regulation of B cell differentiation (GO:0045579)3.14714274
110response to peptidoglycan (GO:0032494)3.14145104
111regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.13447564
112response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.10389658
113response to host immune response (GO:0052572)3.10389658
114positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.10351747
115T cell migration (GO:0072678)3.09403749
116regulation of DNA-dependent DNA replication (GO:0090329)3.09006912
117positive regulation of defense response to virus by host (GO:0002230)3.08266239
118positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.07147408
119regulation of apoptotic process involved in morphogenesis (GO:1902337)3.06770616
120regulation of B cell differentiation (GO:0045577)3.04791519
121positive regulation of protein import into nucleus, translocation (GO:0033160)3.04639383
122antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.03451766
123neural tube formation (GO:0001841)3.02920334
124negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.01877831
125activated T cell proliferation (GO:0050798)3.01862048
126nucleoside transmembrane transport (GO:1901642)3.00380771
127leukocyte aggregation (GO:0070486)3.00261671
128mitotic G2/M transition checkpoint (GO:0044818)3.00074242
129monoubiquitinated protein deubiquitination (GO:0035520)2.99903009
130DNA conformation change (GO:0071103)2.98968304
131detection of biotic stimulus (GO:0009595)2.98379298
132granulocyte activation (GO:0036230)2.97436244
133cellular response to interleukin-15 (GO:0071350)2.96344267
134mitotic nuclear envelope disassembly (GO:0007077)2.94673788
135positive regulation of interferon-alpha production (GO:0032727)2.93939378
136regulation of cilium movement (GO:0003352)2.93834028
137detection of bacterium (GO:0016045)2.92996303
138regulation of interleukin-12 biosynthetic process (GO:0045075)2.90864696
139regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.90829468
140negative regulation of gene silencing (GO:0060969)2.89555101
141negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.89405961
142cell fate commitment involved in formation of primary germ layer (GO:0060795)2.87997803
143negative regulation of B cell proliferation (GO:0030889)2.87504173
144regulation of alpha-beta T cell proliferation (GO:0046640)2.86594781
145regulation of interferon-alpha production (GO:0032647)2.86253161
146positive regulation of protein deacetylation (GO:0090312)2.85454008
147T cell selection (GO:0045058)2.85185490
148attachment of spindle microtubules to kinetochore (GO:0008608)2.84907299
149negative regulation of adaptive immune response (GO:0002820)2.84901054
150histone H3-K4 trimethylation (GO:0080182)2.84811218
151primitive streak formation (GO:0090009)2.84783694
152iron ion import (GO:0097286)2.84594924
153branching involved in mammary gland duct morphogenesis (GO:0060444)2.82838876
154dendritic cell migration (GO:0036336)2.82600829
155antigen processing and presentation of endogenous antigen (GO:0019883)2.82326855
156chromatin assembly or disassembly (GO:0006333)2.81789159
157production of molecular mediator involved in inflammatory response (GO:0002532)2.81697812
158regulation of regulatory T cell differentiation (GO:0045589)2.81422705
159protein localization to chromosome (GO:0034502)2.81017982
160spindle assembly (GO:0051225)2.80449092
161response to host (GO:0075136)2.80137623
162response to host defenses (GO:0052200)2.80137623
163response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.80137623
164DNA damage response, detection of DNA damage (GO:0042769)2.78306339
165regulation of double-strand break repair via homologous recombination (GO:0010569)2.77822769
166establishment of protein localization to Golgi (GO:0072600)2.77403205
167regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.76910816
168germinal center formation (GO:0002467)2.75137484
169positive regulation of toll-like receptor signaling pathway (GO:0034123)2.74930414
170immunoglobulin mediated immune response (GO:0016064)2.74640938
171regulation of necroptotic process (GO:0060544)2.74358112
172hormone catabolic process (GO:0042447)2.73125389
173regulation of gene silencing (GO:0060968)2.73038761
174nuclear envelope disassembly (GO:0051081)2.72184678
175membrane disassembly (GO:0030397)2.72184678
176pseudouridine synthesis (GO:0001522)2.72023695
177positive regulation of cellular amide metabolic process (GO:0034250)2.71984350
178regulation of telomerase activity (GO:0051972)2.71685726
179JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.71200992
180antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70818621
181protein targeting to Golgi (GO:0000042)2.70623652
182defense response to protozoan (GO:0042832)2.69184086
183negative regulation of phagocytosis (GO:0050765)2.69056251
184cellular response to type I interferon (GO:0071357)2.68907663
185type I interferon signaling pathway (GO:0060337)2.68907663
186negative regulation of leukocyte mediated immunity (GO:0002704)2.68366559
187response to muramyl dipeptide (GO:0032495)2.67545090
188leukocyte degranulation (GO:0043299)2.67494581
189peptidyl-lysine trimethylation (GO:0018023)2.67377840
190somatic diversification of immune receptors via somatic mutation (GO:0002566)2.67079272
191somatic hypermutation of immunoglobulin genes (GO:0016446)2.67079272
192B cell mediated immunity (GO:0019724)2.66111665
193trophectodermal cell differentiation (GO:0001829)2.64057219
194regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.63365342
195cullin deneddylation (GO:0010388)2.62096149
196chromosome condensation (GO:0030261)2.61523064
197regulation of chromatin silencing (GO:0031935)2.59853882
198mitochondrion distribution (GO:0048311)2.56633842
199regulation of helicase activity (GO:0051095)2.55781633

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.79920611
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.46051658
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.85486286
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.84406718
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.84406718
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.84406718
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.86959023
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.62934449
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42724758
10GATA1_22025678_ChIP-Seq_K562_Human3.40350498
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.34904973
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.27409815
13* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.94906895
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.77884905
15* IRF8_27001747_Chip-Seq_BMDM_Mouse2.65723327
16RUNX_20019798_ChIP-Seq_JUKART_Human2.62079144
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.61828441
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.58975201
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51448276
20NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.50462704
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49194594
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.45302074
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.44015150
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.32281316
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.31946344
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27571305
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.24077814
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21348469
29* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21099232
30MYB_26560356_Chip-Seq_TH2_Human2.17391921
31EGR1_19374776_ChIP-ChIP_THP-1_Human2.15913138
32POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05615324
33SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.01471762
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91878262
35TCF3_18692474_ChIP-Seq_MEFs_Mouse1.91875462
36* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.86808058
37VDR_24787735_ChIP-Seq_THP-1_Human1.85897933
38* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82789801
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79347804
40MYC_22102868_ChIP-Seq_BL_Human1.75358414
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74681912
42* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73542509
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72848360
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.72328794
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72211709
46* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69090644
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66182659
48NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.65211736
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62558635
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62448372
51GATA3_27048872_Chip-Seq_THYMUS_Human1.57654597
52* SPI1_23127762_ChIP-Seq_K562_Human1.57127809
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55684044
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55621518
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.54548936
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.51539481
57GATA1_19941826_ChIP-Seq_K562_Human1.51500910
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51275126
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.49749564
60* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48539132
61* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45633934
62GATA3_26560356_Chip-Seq_TH2_Human1.45544334
63KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44397603
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.43970442
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43557860
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43330108
67NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.39683545
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39655838
69* GATA2_19941826_ChIP-Seq_K562_Human1.39637837
70SCL_19346495_ChIP-Seq_HPC-7_Human1.38261700
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37705076
72PU_27001747_Chip-Seq_BMDM_Mouse1.37088565
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35836066
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.35777399
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35121255
76IRF1_19129219_ChIP-ChIP_H3396_Human1.34435155
77IRF8_22096565_ChIP-ChIP_GC-B_Human1.33875572
78GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33595809
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.32830579
80TAF15_26573619_Chip-Seq_HEK293_Human1.30342951
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29776280
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29310195
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29031869
84FOXP3_21729870_ChIP-Seq_TREG_Human1.27736657
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27730113
86SALL4_22934838_ChIP-ChIP_CD34+_Human1.26539925
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.26433047
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25560257
89SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24417948
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24314449
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23657369
92* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22746911
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.22251727
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22182265
95TP53_16413492_ChIP-PET_HCT116_Human1.20965009
96BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20949871
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20046412
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19017868
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18542721
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18073604
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17978594
102E2F1_21310950_ChIP-Seq_MCF-7_Human1.15724886
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15711433
104CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15136339
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14915403
106AR_21909140_ChIP-Seq_LNCAP_Human1.14565347
107ER_23166858_ChIP-Seq_MCF-7_Human1.14269802
108NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13839228
109POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12942191
110NANOG_18692474_ChIP-Seq_MEFs_Mouse1.12229961
111* SPI1_23547873_ChIP-Seq_NB4_Human1.11269474
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10582191
113E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10468770
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08595132
115* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.08251019
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.07772184
117TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06862163
118* VDR_23849224_ChIP-Seq_CD4+_Human1.06765340
119FOXO3_23340844_ChIP-Seq_DLD1_Human1.06723552
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.06687490
121CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06360082
122* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06264270
123KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.05423275
124OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05406913
125NANOG_18555785_Chip-Seq_ESCs_Mouse1.04062549
126* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03931088
127IGF1R_20145208_ChIP-Seq_DFB_Human1.03886393
128* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03194976
129SMRT_27268052_Chip-Seq_Bcells_Human1.02971285
130PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01776099
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01717235
132* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01692774
133E2F1_18555785_Chip-Seq_ESCs_Mouse1.01232943
134* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00775858
135STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99682524
136GABP_17652178_ChIP-ChIP_JURKAT_Human0.99486257
137OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99297733
138KDM5A_27292631_Chip-Seq_BREAST_Human0.98853858
139CRX_20693478_ChIP-Seq_RETINA_Mouse0.98301297
140* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98289158
141* TCF7_22412390_ChIP-Seq_EML_Mouse0.98011098
142GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97916580
143ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97689001
144CIITA_25753668_ChIP-Seq_RAJI_Human0.97341992
145* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97277162
146CMYC_18555785_Chip-Seq_ESCs_Mouse0.96447055
147SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96013033
148NANOG_21062744_ChIP-ChIP_HESCs_Human0.95758263
149ELK1_19687146_ChIP-ChIP_HELA_Human0.95656548
150MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95622402
151FLI1_21867929_ChIP-Seq_TH2_Mouse0.95250455
152* PRDM14_20953172_ChIP-Seq_ESCs_Human0.94828637
153STAT3_23295773_ChIP-Seq_U87_Human0.94689458
154JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94642193
155GATA1_19941827_ChIP-Seq_MEL_Mouse0.94148511
156MAF_26560356_Chip-Seq_TH1_Human0.93954248
157RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93592907
158TFEB_21752829_ChIP-Seq_HELA_Human0.93464863
159ETS1_20019798_ChIP-Seq_JURKAT_Human0.93452206
160* XRN2_22483619_ChIP-Seq_HELA_Human0.93357113
161NCOR1_26117541_ChIP-Seq_K562_Human0.93039146
162ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92994725
163SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92881677
164MYB_26560356_Chip-Seq_TH1_Human0.91828808
165* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91811955
166SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91659463
167NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91149662
168NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91149662
169SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90822087
170PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90464098
171* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89559567
172NANOG_16518401_ChIP-PET_MESCs_Mouse0.89534078
173SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89142410
174PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.88814015
175STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88635162
176NANOG_16153702_ChIP-ChIP_HESCs_Human0.88363251
177P53_22387025_ChIP-Seq_ESCs_Mouse0.88268412
178FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87735453
179RUNX1_22412390_ChIP-Seq_EML_Mouse0.86462851
180CDX2_22108803_ChIP-Seq_LS180_Human0.86307073
181MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85102107
182VDR_24763502_ChIP-Seq_THP-1_Human0.85020273
183YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82658655
184E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82445554
185* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80997091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.38072618
2MP0008057_abnormal_DNA_replication4.08765792
3MP0003724_increased_susceptibility_to3.96465278
4MP0003656_abnormal_erythrocyte_physiolo3.68706597
5MP0002254_reproductive_system_inflammat3.36781568
6MP0004264_abnormal_extraembryonic_tissu3.33817893
7MP0003011_delayed_dark_adaptation3.26768359
8MP0004957_abnormal_blastocyst_morpholog3.22926835
9MP0006292_abnormal_olfactory_placode3.19553584
10MP0003303_peritoneal_inflammation3.16334271
11MP0010352_gastrointestinal_tract_polyps2.82703481
12MP0003890_abnormal_embryonic-extraembry2.80467140
13MP0005075_abnormal_melanosome_morpholog2.72456530
14MP0010094_abnormal_chromosome_stability2.60732633
15MP0008260_abnormal_autophagy2.54458837
16MP0002396_abnormal_hematopoietic_system2.54098430
17MP0003077_abnormal_cell_cycle2.53227757
18MP0003111_abnormal_nucleus_morphology2.34136788
19MP0002419_abnormal_innate_immunity2.26478713
20MP0003300_gastrointestinal_ulcer2.12862487
21MP0003693_abnormal_embryo_hatching2.04090950
22MP0003121_genomic_imprinting2.00263791
23MP0005464_abnormal_platelet_physiology1.99959043
24MP0002166_altered_tumor_susceptibility1.99716082
25MP0005499_abnormal_olfactory_system1.96758480
26MP0005394_taste/olfaction_phenotype1.96758480
27MP0002009_preneoplasia1.91784136
28MP0002332_abnormal_exercise_endurance1.89903538
29MP0003705_abnormal_hypodermis_morpholog1.89821329
30MP0000350_abnormal_cell_proliferation1.89187755
31MP0005451_abnormal_body_composition1.87265681
32MP0005380_embryogenesis_phenotype1.86365106
33MP0001672_abnormal_embryogenesis/_devel1.86365106
34MP0006082_CNS_inflammation1.85711983
35MP0002148_abnormal_hypersensitivity_rea1.83243737
36MP0008007_abnormal_cellular_replicative1.82695012
37MP0003172_abnormal_lysosome_physiology1.80278802
38MP0004381_abnormal_hair_follicle1.79597224
39MP0005257_abnormal_intraocular_pressure1.76980074
40MP0002277_abnormal_respiratory_mucosa1.76500132
41MP0001835_abnormal_antigen_presentation1.74998468
42MP0002088_abnormal_embryonic_growth/wei1.73913006
43MP0003984_embryonic_growth_retardation1.73650503
44MP0004947_skin_inflammation1.71350320
45MP0003221_abnormal_cardiomyocyte_apopto1.70456671
46MP0004883_abnormal_blood_vessel1.67266194
47MP0004858_abnormal_nervous_system1.66140971
48MP0000015_abnormal_ear_pigmentation1.64366656
49MP0005310_abnormal_salivary_gland1.59937628
50MP0008058_abnormal_DNA_repair1.59247175
51MP0003183_abnormal_peptide_metabolism1.59093945
52MP0000490_abnormal_crypts_of1.57372438
53MP0009764_decreased_sensitivity_to1.55468132
54MP0006035_abnormal_mitochondrial_morpho1.52261577
55MP0000465_gastrointestinal_hemorrhage1.52188808
56MP0002086_abnormal_extraembryonic_tissu1.47708606
57MP0003122_maternal_imprinting1.47234382
58MP0001293_anophthalmia1.43808519
59MP0003123_paternal_imprinting1.43538055
60MP0002006_tumorigenesis1.40801118
61MP0001845_abnormal_inflammatory_respons1.37919141
62MP0000313_abnormal_cell_death1.35730193
63MP0003191_abnormal_cellular_cholesterol1.33874415
64MP0005164_abnormal_response_to1.31055824
65MP0010155_abnormal_intestine_physiology1.30062990
66MP0004484_altered_response_of1.28486717
67MP0001851_eye_inflammation1.27916414
68MP0001849_ear_inflammation1.26790424
69MP0006054_spinal_hemorrhage1.26483255
70MP0001730_embryonic_growth_arrest1.25341274
71MP0010307_abnormal_tumor_latency1.24556819
72MP0002653_abnormal_ependyma_morphology1.24184766
73MP0002092_abnormal_eye_morphology1.21895580
74MP0002085_abnormal_embryonic_tissue1.21655005
75MP0008004_abnormal_stomach_pH1.20884500
76MP0001533_abnormal_skeleton_physiology1.20604381
77MP0001800_abnormal_humoral_immune1.20365798
78MP0008877_abnormal_DNA_methylation1.19645979
79MP0003786_premature_aging1.17063172
80MP0003436_decreased_susceptibility_to1.16013218
81MP0000689_abnormal_spleen_morphology1.15654779
82MP0008932_abnormal_embryonic_tissue1.15136546
83MP0005174_abnormal_tail_pigmentation1.14886512
84MP0002398_abnormal_bone_marrow1.13966357
85MP0003690_abnormal_glial_cell1.13416055
86MP0002722_abnormal_immune_system1.12691945
87MP0004808_abnormal_hematopoietic_stem1.12391848
88MP0002084_abnormal_developmental_patter1.11975035
89MP0002019_abnormal_tumor_incidence1.10825062
90MP0000678_abnormal_parathyroid_gland1.10487688
91MP0002127_abnormal_cardiovascular_syste1.07611444
92MP0002132_abnormal_respiratory_system1.07258234
93MP0003448_altered_tumor_morphology1.06864781
94MP0004197_abnormal_fetal_growth/weight/1.06715796
95MP0005671_abnormal_response_to1.04661624
96MP0001697_abnormal_embryo_size1.04097808
97MP0002080_prenatal_lethality1.01064660
98MP0003787_abnormal_imprinting1.00135169
99MP0002429_abnormal_blood_cell0.99733481
100MP0003866_abnormal_defecation0.99678988
101MP0008469_abnormal_protein_level0.99511202
102MP0000858_altered_metastatic_potential0.99164781
103MP0005266_abnormal_metabolism0.98896167
104MP0005023_abnormal_wound_healing0.98504776
105MP0003938_abnormal_ear_development0.98078900
106MP0002452_abnormal_antigen_presenting0.98009954
107MP0000716_abnormal_immune_system0.97640465
108MP0005000_abnormal_immune_tolerance0.97440318
109MP0002405_respiratory_system_inflammati0.97050477
110MP0003091_abnormal_cell_migration0.96858033
111MP0000371_diluted_coat_color0.96710382
112MP0008961_abnormal_basal_metabolism0.95879325
113MP0004130_abnormal_muscle_cell0.94604878
114MP0002420_abnormal_adaptive_immunity0.93799920
115MP0001819_abnormal_immune_cell0.93733113
116MP0009785_altered_susceptibility_to0.93286960
117MP0005025_abnormal_response_to0.91231976
118MP0001790_abnormal_immune_system0.90069192
119MP0005387_immune_system_phenotype0.90069192
120MP0005397_hematopoietic_system_phenotyp0.89787792
121MP0001545_abnormal_hematopoietic_system0.89787792
122MP0002998_abnormal_bone_remodeling0.88712897
123MP0001853_heart_inflammation0.87800788
124MP0000703_abnormal_thymus_morphology0.86977710
125MP0004147_increased_porphyrin_level0.86844934
126MP0009765_abnormal_xenobiotic_induced0.86772031
127MP0002723_abnormal_immune_serum0.85915969
128MP0003828_pulmonary_edema0.85521012
129MP0003045_fibrosis0.85376433
130MP0003763_abnormal_thymus_physiology0.84904987
131MP0009278_abnormal_bone_marrow0.82071609
132MP0002970_abnormal_white_adipose0.80810264
133MP0009763_increased_sensitivity_to0.80522911
134MP0002932_abnormal_joint_morphology0.80223913
135MP0000432_abnormal_head_morphology0.79144829
136MP0008995_early_reproductive_senescence0.78865701
137MP0005384_cellular_phenotype0.78313359
138MP0002925_abnormal_cardiovascular_devel0.77068392
139MP0008770_decreased_survivor_rate0.76284042
140MP0003566_abnormal_cell_adhesion0.75530033
141MP0003453_abnormal_keratinocyte_physiol0.75493458
142MP0000685_abnormal_immune_system0.74274360
143MP0009333_abnormal_splenocyte_physiolog0.73096382
144MP0000249_abnormal_blood_vessel0.72255097
145MP0000358_abnormal_cell_content/0.70897797
146MP0000428_abnormal_craniofacial_morphol0.70799440
147MP0001348_abnormal_lacrimal_gland0.70008429
148MP0000604_amyloidosis0.69989210
149MP0005621_abnormal_cell_physiology0.69565588
150MP0005376_homeostasis/metabolism_phenot0.69512675
151MP0010678_abnormal_skin_adnexa0.67349922
152MP0000427_abnormal_hair_cycle0.66441060
153MP0004510_myositis0.66403659
154MP0003646_muscle_fatigue0.64609351
155MP0009115_abnormal_fat_cell0.64464527
156MP0002095_abnormal_skin_pigmentation0.63369369
157MP0005388_respiratory_system_phenotype0.62752744
158MP0002133_abnormal_respiratory_system0.62752744

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.76286793
2Hypochromic microcytic anemia (HP:0004840)5.72076449
3Recurrent bacterial skin infections (HP:0005406)5.08042186
4T lymphocytopenia (HP:0005403)5.04113177
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.67057654
6Ependymoma (HP:0002888)4.64368630
7Abnormality of T cell number (HP:0011839)4.61806631
8Eczematoid dermatitis (HP:0000976)4.48010339
9Recurrent abscess formation (HP:0002722)4.41193550
10Multiple enchondromatosis (HP:0005701)4.37268848
11Chromsome breakage (HP:0040012)4.33894138
12Stomatitis (HP:0010280)4.30566615
13Hepatoblastoma (HP:0002884)4.15589947
14Optic neuritis (HP:0100653)4.07217733
15Retrobulbar optic neuritis (HP:0100654)4.07217733
16Rib fusion (HP:0000902)3.98015919
17Abnormality of the lower motor neuron (HP:0002366)3.86848731
18Rhabdomyosarcoma (HP:0002859)3.83278887
19Spontaneous hematomas (HP:0007420)3.67176659
20Nephroblastoma (Wilms tumor) (HP:0002667)3.65449071
21Gastrointestinal infarctions (HP:0005244)3.64499592
22Neoplasm of striated muscle (HP:0009728)3.58449319
23Recurrent fungal infections (HP:0002841)3.52726929
24Keratoconjunctivitis sicca (HP:0001097)3.45803221
25Embryonal renal neoplasm (HP:0011794)3.40072390
26Autoimmune hemolytic anemia (HP:0001890)3.35744978
27Recurrent skin infections (HP:0001581)3.34269383
28Astrocytoma (HP:0009592)3.27268211
29Abnormality of the astrocytes (HP:0100707)3.27268211
30Keratoconjunctivitis (HP:0001096)3.25440681
31Abnormality of macrophages (HP:0004311)3.22623067
32Papillary thyroid carcinoma (HP:0002895)3.15656916
33Gingival bleeding (HP:0000225)3.13326518
34Recurrent cutaneous fungal infections (HP:0011370)3.06397027
35Chronic mucocutaneous candidiasis (HP:0002728)3.06397027
36Meckel diverticulum (HP:0002245)3.04319584
37Recurrent viral infections (HP:0004429)2.99336478
38Prolonged bleeding time (HP:0003010)2.97794538
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.97732488
40Abnormality of T cells (HP:0002843)2.96732688
41Rectal fistula (HP:0100590)2.95472905
42Rectovaginal fistula (HP:0000143)2.95472905
43Recurrent gram-negative bacterial infections (HP:0005420)2.94755648
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.92964486
45Poikilocytosis (HP:0004447)2.90492590
46Leukocytosis (HP:0001974)2.90276255
47Gingivitis (HP:0000230)2.88553582
48Abnormality of the ileum (HP:0001549)2.86342271
49Subacute progressive viral hepatitis (HP:0006572)2.84547908
50Intestinal fistula (HP:0100819)2.83547010
51Hypochromic anemia (HP:0001931)2.81455296
52Fused cervical vertebrae (HP:0002949)2.80011407
53Impulsivity (HP:0100710)2.78107559
54Abnormal lung lobation (HP:0002101)2.74461811
55Mediastinal lymphadenopathy (HP:0100721)2.73268292
56Medulloblastoma (HP:0002885)2.72645025
57Hematochezia (HP:0002573)2.71593547
58Aplasia/Hypoplasia of the fovea (HP:0008060)2.71521079
59Hypoplasia of the fovea (HP:0007750)2.71521079
60Abnormality of the heme biosynthetic pathway (HP:0010472)2.70031914
61Abnormality of the salivary glands (HP:0010286)2.68805448
62Encephalitis (HP:0002383)2.68667014
63Stomach cancer (HP:0012126)2.61955887
64Arterial thrombosis (HP:0004420)2.61922234
65Vasculitis (HP:0002633)2.61771753
66Aplasia/hypoplasia of the humerus (HP:0006507)2.60823801
67Chest pain (HP:0100749)2.59877243
68Glioma (HP:0009733)2.58260895
69Reduced antithrombin III activity (HP:0001976)2.57081866
70Microcytic anemia (HP:0001935)2.55016356
71Short humerus (HP:0005792)2.54540794
72Neoplasm of the tracheobronchial system (HP:0100552)2.54421049
73Acute myeloid leukemia (HP:0004808)2.54090961
74Upper motor neuron abnormality (HP:0002127)2.53026651
75Vaginal fistula (HP:0004320)2.51880084
76Epistaxis (HP:0000421)2.51528146
77Supernumerary spleens (HP:0009799)2.51034027
78Slow saccadic eye movements (HP:0000514)2.50122345
79Meningitis (HP:0001287)2.48177999
80Myelodysplasia (HP:0002863)2.47657839
81Hemoptysis (HP:0002105)2.45464858
82Amyotrophic lateral sclerosis (HP:0007354)2.43901304
83Abnormality of the fingertips (HP:0001211)2.43284745
84Trismus (HP:0000211)2.43169979
85Recurrent bronchitis (HP:0002837)2.41942699
86Abnormality of chromosome stability (HP:0003220)2.40392638
87Duodenal stenosis (HP:0100867)2.40091251
88Small intestinal stenosis (HP:0012848)2.40091251
89Inflammation of the large intestine (HP:0002037)2.38353896
90Combined immunodeficiency (HP:0005387)2.38338180
91Colitis (HP:0002583)2.36362000
92Thyroiditis (HP:0100646)2.36129051
93Volvulus (HP:0002580)2.35054811
94Chronic diarrhea (HP:0002028)2.34905131
95Osteomyelitis (HP:0002754)2.34292121
96Pulmonary infiltrates (HP:0002113)2.33064306
97Eosinophilia (HP:0001880)2.31512816
98Viral hepatitis (HP:0006562)2.31385099
99Testicular atrophy (HP:0000029)2.30428891
100Preauricular skin tag (HP:0000384)2.30168292
101Curly hair (HP:0002212)2.28089825
102Abnormality of the preputium (HP:0100587)2.25532536
103Abnormality of chromosome segregation (HP:0002916)2.25171434
104Shawl scrotum (HP:0000049)2.24448807
105Abnormality of eosinophils (HP:0001879)2.24198941
106Urticaria (HP:0001025)2.20189895
107Alveolar cell carcinoma (HP:0006519)2.18846799
108Horizontal nystagmus (HP:0000666)2.18546155
109Partial duplication of thumb phalanx (HP:0009944)2.17923239
110Abnormality of the vasculature of the conjunctiva (HP:0008054)2.17571793
111Agnosia (HP:0010524)2.13730945
112Elevated erythrocyte sedimentation rate (HP:0003565)2.13424172
113Pustule (HP:0200039)2.12794559
114Large earlobe (HP:0009748)2.12049616
115Thyroid carcinoma (HP:0002890)2.10701782
116Obstructive lung disease (HP:0006536)2.09937643
117Chronic obstructive pulmonary disease (HP:0006510)2.09937643
118Granulocytopenia (HP:0001913)2.09799737
119Gangrene (HP:0100758)2.09570599
120IgM deficiency (HP:0002850)2.09029438
121Skin tags (HP:0010609)2.08760789
122Polycythemia (HP:0001901)2.08165566
123Aplastic anemia (HP:0001915)2.07839725
124Autoimmune thrombocytopenia (HP:0001973)2.07465951
125Orchitis (HP:0100796)2.06692802
126Gastrointestinal inflammation (HP:0004386)2.05485384
127Myositis (HP:0100614)2.05254811
128Pendular nystagmus (HP:0012043)2.04788996
129Neoplasm of the oral cavity (HP:0100649)2.04545508
130Conjunctival telangiectasia (HP:0000524)2.02133739
131Ragged-red muscle fibers (HP:0003200)2.01884586
132Aplasia/Hypoplasia of the sternum (HP:0006714)2.01664282
133Peritonitis (HP:0002586)2.01523635
134Absent frontal sinuses (HP:0002688)2.00367890
135Sloping forehead (HP:0000340)2.00255650
136Abnormality of the fovea (HP:0000493)1.99839276
137Bone marrow hypocellularity (HP:0005528)1.99585028
138Abnormal cartilage morphology (HP:0002763)1.99341352
139Fatigue (HP:0012378)1.98927412
140Bifid tongue (HP:0010297)1.97962997
141Tongue fasciculations (HP:0001308)1.97795430
142Anomalous pulmonary venous return (HP:0010772)1.97451697
143Abnormal platelet volume (HP:0011876)1.97402739
144Pulmonary embolism (HP:0002204)1.97195949
145Cheilitis (HP:0100825)1.96573148
146Short 5th finger (HP:0009237)1.96311542
147Periodontitis (HP:0000704)1.96298916
148Missing ribs (HP:0000921)1.95631379
149Acute hepatic failure (HP:0006554)1.95062073
150Acanthocytosis (HP:0001927)1.94967065
151Type I transferrin isoform profile (HP:0003642)1.94553479
152Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94448009
153Spinal muscular atrophy (HP:0007269)1.94246440
154Atrophy/Degeneration involving motor neurons (HP:0007373)1.94185276
155Abnormality of T cell physiology (HP:0011840)1.94010226
156Abnormality of the duodenum (HP:0002246)1.92584763
157Nasal polyposis (HP:0100582)1.90606734
158Hyperinsulinemic hypoglycemia (HP:0000825)1.89702741
159Postural instability (HP:0002172)1.88112669
160Aplasia/Hypoplasia of the macula (HP:0008059)1.87459378
161Panhypogammaglobulinemia (HP:0003139)1.87023229
162Periauricular skin pits (HP:0100277)1.86465261
163Preauricular pit (HP:0004467)1.86465261
164Abnormality of glycolipid metabolism (HP:0010969)1.86376947
165Abnormality of liposaccharide metabolism (HP:0010968)1.86376947
166Abnormality of glycosphingolipid metabolism (HP:0004343)1.86376947
167Clubbing of toes (HP:0100760)1.84685362
168Villous atrophy (HP:0011473)1.84137159
169Abnormality of small intestinal villus morphology (HP:0011472)1.84137159
170Anorexia (HP:0002039)1.83670952
171Keratitis (HP:0000491)1.83449664
172Glossoptosis (HP:0000162)1.83448917
173Malignant neoplasm of the central nervous system (HP:0100836)1.83224380
174Partial duplication of the phalanx of hand (HP:0009999)1.83088318
175Increased connective tissue (HP:0009025)1.83042448
176Selective tooth agenesis (HP:0001592)1.82219939
177Disinhibition (HP:0000734)1.79496902
178Microretrognathia (HP:0000308)1.78966052
179Widely spaced teeth (HP:0000687)1.78800498
180Embryonal neoplasm (HP:0002898)1.78426502
181Increased mean platelet volume (HP:0011877)1.77504357
182Hypopigmentation of the fundus (HP:0007894)1.77371374
183Supernumerary ribs (HP:0005815)1.77343167
184Cellulitis (HP:0100658)1.76469835
185Atresia of the external auditory canal (HP:0000413)1.75180494
186Amaurosis fugax (HP:0100576)1.74736607
187Muscle fibrillation (HP:0010546)1.73462379
188Severe combined immunodeficiency (HP:0004430)1.70961990
189Abnormality of B cell number (HP:0010975)1.70632419
190Degeneration of the lateral corticospinal tracts (HP:0002314)1.69999104
191Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69999104
192Myocardial infarction (HP:0001658)1.69712028
193Albinism (HP:0001022)1.67834123
194Vertigo (HP:0002321)1.67739843

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.09142911
2GRK53.90487822
3ERN13.81007047
4GRK63.74404981
5CSF1R3.30795617
6RIPK43.21912748
7TGFBR22.88804803
8TTK2.82207881
9STK102.71348630
10GRK12.54351543
11ADRBK22.53770604
12MATK2.22496516
13IKBKE2.19685633
14GRK72.12957823
15TAOK32.10274456
16BMPR22.08832952
17FGR1.99534658
18MAPK71.93961448
19FRK1.85519328
20JAK11.84921255
21CDK71.84195590
22TEC1.77256070
23CDC71.77134620
24FES1.74705677
25MAP3K21.69501465
26WEE11.69097055
27MOS1.68113546
28TYRO31.64965529
29SGK21.63040438
30PIK3CG1.60607828
31JAK21.50604963
32MARK31.50206125
33NLK1.48751152
34PLK11.46680040
35EPHA21.44205223
36NEK21.42411987
37CHEK21.39868217
38WNK11.39115509
39PAK41.37665576
40IRAK11.30256918
41KSR11.27785542
42FGFR31.26339347
43MAP3K61.25157274
44SGK31.24690431
45EPHA31.18546763
46MAP3K101.15644600
47ACVR1B1.15220881
48CAMKK21.13565865
49CAMK41.12915178
50PRKG21.12627989
51MAP3K31.11540699
52KSR21.07841596
53CHEK11.07627256
54TRPM71.06891445
55SRPK11.04941219
56PTK2B1.03656169
57PRPF4B1.03128727
58MST41.02625404
59CSK1.02218264
60EIF2AK20.98048006
61ERBB30.97978679
62BUB10.95766596
63PLK20.95424827
64NEK90.93027554
65CDK40.92050736
66AKT30.90342471
67KIT0.88582274
68FLT30.88021840
69RAF10.87348059
70IKBKB0.87322463
71MAP3K130.85976598
72ATR0.84714322
73HIPK20.81687214
74AURKB0.81471783
75MAP3K50.81349379
76MAP3K10.81078898
77TBK10.80834622
78MAP4K10.80228562
79RPS6KB20.79343900
80ALK0.79075485
81SGK4940.78114796
82SGK2230.78114796
83ATM0.76254375
84BRSK20.75374652
85STK40.74109357
86SIK30.73218475
87NEK60.72503452
88TAOK10.72285848
89STK240.71333124
90PIM10.68297112
91CDK20.67257536
92ADRBK10.66519070
93TYK20.66302235
94DYRK1A0.65170891
95DYRK30.63194147
96NUAK10.62884283
97ITK0.62162537
98CHUK0.61925443
99PAK30.60799460
100MARK20.60605288
101EGFR0.59683858
102SGK10.58297918
103AKT20.56756709
104TNK20.55245698
105MAP2K60.54741218
106EIF2AK30.54580499
107FER0.53956216
108OBSCN0.53441556
109BLK0.53003218
110IRAK20.52890930
111EIF2AK10.52163444
112NEK10.50836492
113PDK10.50085476
114RET0.49992385
115PDGFRB0.49506591
116JAK30.49228976
117CAMK1D0.48344257
118MTOR0.47890549
119NTRK10.45578490
120PRKAA20.45358931
121STK380.45240034
122DYRK1B0.44094233
123MAP3K40.44012838
124MAP3K80.42278890
125MAP2K40.41716470
126CDK10.39202277
127AURKA0.38382360
128IGF1R0.37181120
129YES10.37081876
130BRD40.35264277
131HCK0.34439664
132ZAK0.34003849
133TSSK60.32578576
134PRKCD0.31075331
135LCK0.31045641
136IRAK40.30404514
137PRKCI0.30356780
138TGFBR10.30031160
139PLK40.29806966
140MAPK120.29469164
141MAPK140.28772643
142PAK10.28348371
143ZAP700.28061662
144PIM20.27947543
145VRK10.27789586
146BTK0.26978302
147MAPK10.26122269
148TXK0.25703212
149STK30.24986000
150MELK0.24739388
151CDK60.24249822
152CLK10.23784983
153RPS6KA40.22824360
154MAP2K30.22134165
155SYK0.21820287
156BRSK10.21728887
157LYN0.20463581
158MAP3K140.19714195
159MAPK40.19563379
160PLK30.19028688

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.04696861
2Vitamin B6 metabolism_Homo sapiens_hsa007503.76730472
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.62132974
4DNA replication_Homo sapiens_hsa030302.86067818
5Mismatch repair_Homo sapiens_hsa034302.62095942
6Fructose and mannose metabolism_Homo sapiens_hsa000512.27753975
7RNA transport_Homo sapiens_hsa030132.27733841
8Fanconi anemia pathway_Homo sapiens_hsa034602.23341280
9Homologous recombination_Homo sapiens_hsa034402.09534948
10Cell cycle_Homo sapiens_hsa041102.04711468
11One carbon pool by folate_Homo sapiens_hsa006701.83356690
12Base excision repair_Homo sapiens_hsa034101.81614502
13Spliceosome_Homo sapiens_hsa030401.75178191
14Galactose metabolism_Homo sapiens_hsa000521.67354968
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66606638
16mRNA surveillance pathway_Homo sapiens_hsa030151.63060934
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62396488
18Herpes simplex infection_Homo sapiens_hsa051681.59919841
19Non-homologous end-joining_Homo sapiens_hsa034501.58956206
20Arachidonic acid metabolism_Homo sapiens_hsa005901.57377922
21RNA degradation_Homo sapiens_hsa030181.50851478
22Dorso-ventral axis formation_Homo sapiens_hsa043201.45446685
23Autoimmune thyroid disease_Homo sapiens_hsa053201.44450905
24Platelet activation_Homo sapiens_hsa046111.42757697
25Chemokine signaling pathway_Homo sapiens_hsa040621.41481320
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.40862225
27p53 signaling pathway_Homo sapiens_hsa041151.39623202
28Nucleotide excision repair_Homo sapiens_hsa034201.37739179
29Prolactin signaling pathway_Homo sapiens_hsa049171.35310181
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30285115
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29372796
32FoxO signaling pathway_Homo sapiens_hsa040681.28179139
33Renal cell carcinoma_Homo sapiens_hsa052111.27347476
34Thyroid cancer_Homo sapiens_hsa052161.25846043
35Primary immunodeficiency_Homo sapiens_hsa053401.25623044
36Basal transcription factors_Homo sapiens_hsa030221.22384184
37Leishmaniasis_Homo sapiens_hsa051401.20732484
38Type I diabetes mellitus_Homo sapiens_hsa049401.19164442
39Ribosome_Homo sapiens_hsa030101.18079478
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16423342
41Other glycan degradation_Homo sapiens_hsa005111.12773535
42Asthma_Homo sapiens_hsa053101.10807482
43RNA polymerase_Homo sapiens_hsa030201.10705468
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10051197
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09905606
46Legionellosis_Homo sapiens_hsa051341.07843085
47Antigen processing and presentation_Homo sapiens_hsa046121.06987087
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.05722710
49mTOR signaling pathway_Homo sapiens_hsa041501.05559269
50Endometrial cancer_Homo sapiens_hsa052131.02616420
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.01397344
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00389386
53Influenza A_Homo sapiens_hsa051640.99202907
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96351179
55Measles_Homo sapiens_hsa051620.96127551
56Linoleic acid metabolism_Homo sapiens_hsa005910.95364919
57Apoptosis_Homo sapiens_hsa042100.93063810
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92372230
59Viral carcinogenesis_Homo sapiens_hsa052030.91630032
60MicroRNAs in cancer_Homo sapiens_hsa052060.91402962
61Acute myeloid leukemia_Homo sapiens_hsa052210.91381436
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.90303766
63Rheumatoid arthritis_Homo sapiens_hsa053230.89481499
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89259651
65B cell receptor signaling pathway_Homo sapiens_hsa046620.87809988
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87707240
67Pyrimidine metabolism_Homo sapiens_hsa002400.87337583
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86649309
69Phagosome_Homo sapiens_hsa041450.85284142
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84984793
71Viral myocarditis_Homo sapiens_hsa054160.84492938
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84477524
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.83307065
74Prostate cancer_Homo sapiens_hsa052150.82250611
75Type II diabetes mellitus_Homo sapiens_hsa049300.82186142
76HIF-1 signaling pathway_Homo sapiens_hsa040660.80025392
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79596656
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.79526877
79VEGF signaling pathway_Homo sapiens_hsa043700.78385159
80Pentose phosphate pathway_Homo sapiens_hsa000300.77235466
81Hematopoietic cell lineage_Homo sapiens_hsa046400.75974153
82Regulation of autophagy_Homo sapiens_hsa041400.73707650
83Choline metabolism in cancer_Homo sapiens_hsa052310.72535457
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71451101
85ErbB signaling pathway_Homo sapiens_hsa040120.71213295
86Glioma_Homo sapiens_hsa052140.68962817
87HTLV-I infection_Homo sapiens_hsa051660.68874768
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66418980
89Shigellosis_Homo sapiens_hsa051310.66298760
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65847891
91Circadian rhythm_Homo sapiens_hsa047100.65276415
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65232784
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65002055
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.64880518
95Insulin resistance_Homo sapiens_hsa049310.64841728
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64488193
97Pathways in cancer_Homo sapiens_hsa052000.64440409
98Small cell lung cancer_Homo sapiens_hsa052220.64328222
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63864012
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63818993
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.63587608
102Toxoplasmosis_Homo sapiens_hsa051450.62366019
103Epstein-Barr virus infection_Homo sapiens_hsa051690.62321156
104African trypanosomiasis_Homo sapiens_hsa051430.60654414
105Pancreatic cancer_Homo sapiens_hsa052120.59962458
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59704961
107Salmonella infection_Homo sapiens_hsa051320.59506551
108Notch signaling pathway_Homo sapiens_hsa043300.58479877
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57391185
110Systemic lupus erythematosus_Homo sapiens_hsa053220.55957088
111Inositol phosphate metabolism_Homo sapiens_hsa005620.55102060
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54676563
113Colorectal cancer_Homo sapiens_hsa052100.54575932
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.53947497
115Hepatitis B_Homo sapiens_hsa051610.53626562
116GnRH signaling pathway_Homo sapiens_hsa049120.53272523
117Tuberculosis_Homo sapiens_hsa051520.53270321
118Non-small cell lung cancer_Homo sapiens_hsa052230.52023237
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.51980342
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51882341
121Amoebiasis_Homo sapiens_hsa051460.51804156
122MAPK signaling pathway_Homo sapiens_hsa040100.50307107
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48926577
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48253630
125T cell receptor signaling pathway_Homo sapiens_hsa046600.48207796
126Allograft rejection_Homo sapiens_hsa053300.46999371
127Proteasome_Homo sapiens_hsa030500.45848608
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45206644
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44606278
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44352052
131Hepatitis C_Homo sapiens_hsa051600.43793864
132Long-term potentiation_Homo sapiens_hsa047200.43166757
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42535326
134Lysosome_Homo sapiens_hsa041420.42238961
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40835177
136Osteoclast differentiation_Homo sapiens_hsa043800.40091221
137TNF signaling pathway_Homo sapiens_hsa046680.39361031
138Malaria_Homo sapiens_hsa051440.38461603
139Pertussis_Homo sapiens_hsa051330.38440677
140Graft-versus-host disease_Homo sapiens_hsa053320.37045689
141Folate biosynthesis_Homo sapiens_hsa007900.36548827
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36423412
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34828008
144Chronic myeloid leukemia_Homo sapiens_hsa052200.33485725
145Adherens junction_Homo sapiens_hsa045200.33424221
146Selenocompound metabolism_Homo sapiens_hsa004500.33404835
147Staphylococcus aureus infection_Homo sapiens_hsa051500.33041728

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