MORF4L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)4.81310745
2DNA double-strand break processing (GO:0000729)4.44197315
3neuron cell-cell adhesion (GO:0007158)4.25790347
4synaptic vesicle exocytosis (GO:0016079)3.71847015
5acrosome reaction (GO:0007340)3.69172051
6epithelial cilium movement (GO:0003351)3.68871784
7piRNA metabolic process (GO:0034587)3.65690350
8chromatin remodeling at centromere (GO:0031055)3.58864152
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.56914460
10negative regulation of DNA-dependent DNA replication (GO:2000104)3.54579094
11sperm motility (GO:0030317)3.54362435
12fusion of sperm to egg plasma membrane (GO:0007342)3.49956941
13CENP-A containing nucleosome assembly (GO:0034080)3.48698491
14regulation of synaptic vesicle exocytosis (GO:2000300)3.45306561
15vocalization behavior (GO:0071625)3.42752041
16axonemal dynein complex assembly (GO:0070286)3.40467934
17presynaptic membrane assembly (GO:0097105)3.40295484
18cilium movement (GO:0003341)3.39723239
19protein localization to cilium (GO:0061512)3.38728429
20neuron recognition (GO:0008038)3.37563723
21proteasome assembly (GO:0043248)3.34845122
22presynaptic membrane organization (GO:0097090)3.30353322
23histone exchange (GO:0043486)3.30062885
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.28025416
25calcium ion-dependent exocytosis (GO:0017156)3.23555766
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.22143497
27transmission of nerve impulse (GO:0019226)3.21910720
28negative regulation of neurotransmitter transport (GO:0051589)3.18035006
29protein localization to synapse (GO:0035418)3.17796865
30regulation of cilium movement (GO:0003352)3.17086193
31cullin deneddylation (GO:0010388)3.16743199
32regulation of meiosis I (GO:0060631)3.14975455
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14586713
34regulation of glutamate receptor signaling pathway (GO:1900449)3.14060533
35negative regulation of DNA recombination (GO:0045910)3.13341108
36plasma membrane fusion (GO:0045026)3.10725859
37ionotropic glutamate receptor signaling pathway (GO:0035235)3.08977730
38neuronal action potential propagation (GO:0019227)3.06357147
39acrosome assembly (GO:0001675)3.03442971
40replication fork processing (GO:0031297)3.02673905
41positive regulation of synapse assembly (GO:0051965)3.01915102
42negative regulation of microtubule polymerization (GO:0031115)3.01821633
43sperm-egg recognition (GO:0035036)2.98021915
44neuron-neuron synaptic transmission (GO:0007270)2.97503746
45ATP hydrolysis coupled proton transport (GO:0015991)2.97353265
46energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.97353265
47spermatid development (GO:0007286)2.96076329
48gamma-aminobutyric acid signaling pathway (GO:0007214)2.95811193
49axon ensheathment in central nervous system (GO:0032291)2.95137402
50central nervous system myelination (GO:0022010)2.95137402
51regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.94162492
52regulation of mitotic spindle checkpoint (GO:1903504)2.94162492
53DNA ligation (GO:0006266)2.93232985
54regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.93213750
55metaphase plate congression (GO:0051310)2.93093645
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.92145606
57synapsis (GO:0007129)2.91997063
58synaptonemal complex organization (GO:0070193)2.91583201
59male meiosis (GO:0007140)2.89465506
60regulation of protein kinase A signaling (GO:0010738)2.89232787
61glutamate secretion (GO:0014047)2.87284768
62kinetochore organization (GO:0051383)2.85273035
63pyrimidine nucleobase catabolic process (GO:0006208)2.84945770
64axonal fasciculation (GO:0007413)2.84184332
65intraciliary transport (GO:0042073)2.82566854
66regulation of synaptic vesicle transport (GO:1902803)2.82473768
67DNA replication-independent nucleosome organization (GO:0034724)2.81104185
68DNA replication-independent nucleosome assembly (GO:0006336)2.81104185
69binding of sperm to zona pellucida (GO:0007339)2.80007715
70synaptic transmission, glutamatergic (GO:0035249)2.79825114
71resolution of meiotic recombination intermediates (GO:0000712)2.79378680
72negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.79370860
73glutamate receptor signaling pathway (GO:0007215)2.78892989
74positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.78365654
75DNA replication-dependent nucleosome organization (GO:0034723)2.77325033
76DNA replication-dependent nucleosome assembly (GO:0006335)2.77325033
77mitotic metaphase plate congression (GO:0007080)2.77053884
78kinetochore assembly (GO:0051382)2.76623709
79locomotory exploration behavior (GO:0035641)2.75276363
80regulation of centriole replication (GO:0046599)2.75089863
81mating behavior (GO:0007617)2.74670283
82startle response (GO:0001964)2.73871260
83neurotransmitter secretion (GO:0007269)2.72735247
84dendritic spine morphogenesis (GO:0060997)2.72553108
85lactate metabolic process (GO:0006089)2.71050517
86synaptic vesicle docking involved in exocytosis (GO:0016081)2.70317554
87DNA damage response, detection of DNA damage (GO:0042769)2.69031714
88non-recombinational repair (GO:0000726)2.68790485
89double-strand break repair via nonhomologous end joining (GO:0006303)2.68790485
90spindle checkpoint (GO:0031577)2.68132776
91respiratory chain complex IV assembly (GO:0008535)2.68059215
92microtubule severing (GO:0051013)2.67373978
93regulation of glutamate secretion (GO:0014048)2.67167803
94postreplication repair (GO:0006301)2.67071372
95protein localization to kinetochore (GO:0034501)2.66358535
96energy coupled proton transport, down electrochemical gradient (GO:0015985)2.66105982
97ATP synthesis coupled proton transport (GO:0015986)2.66105982
98ventricular system development (GO:0021591)2.63535166
99negative regulation of inclusion body assembly (GO:0090084)2.62970785
100motile cilium assembly (GO:0044458)2.62054502
101long-term synaptic potentiation (GO:0060291)2.61471823
102regulation of DNA endoreduplication (GO:0032875)2.61321870
103exploration behavior (GO:0035640)2.61294876
104DNA catabolic process, exonucleolytic (GO:0000738)2.60501806
105synaptic vesicle endocytosis (GO:0048488)2.60201520
106establishment of integrated proviral latency (GO:0075713)2.60156468
107microtubule depolymerization (GO:0007019)2.60154624
108regulation of nuclear cell cycle DNA replication (GO:0033262)2.59953425
109maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.58526297
110synaptonemal complex assembly (GO:0007130)2.58199916
111regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.58088641
112regulation of microtubule-based movement (GO:0060632)2.57911078
113regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.57880329
114substantia nigra development (GO:0021762)2.57798092
115mitotic sister chromatid cohesion (GO:0007064)2.57465073
116regulation of long-term neuronal synaptic plasticity (GO:0048169)2.56550731
117neuronal ion channel clustering (GO:0045161)2.56430301
118mitotic spindle checkpoint (GO:0071174)2.55946473
119somatic diversification of immune receptors via somatic mutation (GO:0002566)2.55935588
120somatic hypermutation of immunoglobulin genes (GO:0016446)2.55935588
121multicellular organism reproduction (GO:0032504)2.55720062
122regulation of helicase activity (GO:0051095)2.55174763
123centriole replication (GO:0007099)2.54734369
124water-soluble vitamin biosynthetic process (GO:0042364)2.54666521
125cell-cell recognition (GO:0009988)2.53449104
126positive regulation of cellular response to oxidative stress (GO:1900409)2.52754486
127positive regulation of response to oxidative stress (GO:1902884)2.52754486
128female gonad development (GO:0008585)2.52690584
129peptidyl-cysteine modification (GO:0018198)2.52313697
130telomere maintenance via telomerase (GO:0007004)2.51787960
131microtubule polymerization or depolymerization (GO:0031109)2.51767262
132limb bud formation (GO:0060174)2.51564627
133protein deneddylation (GO:0000338)2.51195059
134protein neddylation (GO:0045116)2.51188956
135negative regulation of neurotransmitter secretion (GO:0046929)2.50299569
136layer formation in cerebral cortex (GO:0021819)2.49894917
137establishment of protein localization to mitochondrial membrane (GO:0090151)2.49784299
138cerebellar granule cell differentiation (GO:0021707)2.49129940
139DNA replication checkpoint (GO:0000076)2.48316968
140dendrite development (GO:0016358)2.47586781
141protein K11-linked ubiquitination (GO:0070979)2.47113444
142neurotransmitter uptake (GO:0001504)2.46500949
143synaptic vesicle maturation (GO:0016188)2.45937644
144nonmotile primary cilium assembly (GO:0035058)2.45313283
145attachment of spindle microtubules to kinetochore (GO:0008608)2.44906012
146response to pheromone (GO:0019236)2.44460961
147regulation of neuronal synaptic plasticity (GO:0048168)2.44451510
148neurotransmitter transport (GO:0006836)2.43179928
149transferrin transport (GO:0033572)2.42417365
150nucleobase catabolic process (GO:0046113)2.42242483
151platelet dense granule organization (GO:0060155)2.39775253
152DNA methylation involved in gamete generation (GO:0043046)2.38939259
153negative regulation of synaptic transmission, GABAergic (GO:0032229)2.38877975
154regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.38678303
155regulation of glucokinase activity (GO:0033131)2.38398706
156regulation of hexokinase activity (GO:1903299)2.38398706
157postsynaptic membrane organization (GO:0001941)2.37988331
158regulation of excitatory postsynaptic membrane potential (GO:0060079)2.37376853
159long-chain fatty acid biosynthetic process (GO:0042759)2.37343811
160exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.37034057
161negative regulation of mitotic sister chromatid segregation (GO:0033048)2.36696530
162negative regulation of mitotic sister chromatid separation (GO:2000816)2.36696530
163negative regulation of sister chromatid segregation (GO:0033046)2.36696530
164negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.36696530
165negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.36696530
166purine nucleobase biosynthetic process (GO:0009113)2.36461114
167somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.34567152
168somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.34567152
169isotype switching (GO:0045190)2.34567152
170nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.33972808
171regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.30257263
172glycosphingolipid biosynthetic process (GO:0006688)2.29155634
173mitotic spindle organization (GO:0007052)2.28121960
174regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.27982951
175regulation of mitotic metaphase/anaphase transition (GO:0030071)2.27982951
176negative regulation of chromosome segregation (GO:0051985)2.26636479
177regulation of acyl-CoA biosynthetic process (GO:0050812)2.26600081
178cilium morphogenesis (GO:0060271)2.26131471
179histone mRNA metabolic process (GO:0008334)2.26034963
180branched-chain amino acid catabolic process (GO:0009083)2.25417263
181regulation of telomere maintenance (GO:0032204)2.25209060
182regulation of sister chromatid segregation (GO:0033045)2.24138286
183regulation of mitotic sister chromatid separation (GO:0010965)2.24138286
184regulation of mitotic sister chromatid segregation (GO:0033047)2.24138286
185establishment of chromosome localization (GO:0051303)2.23877994
186regulation of coenzyme metabolic process (GO:0051196)2.23406162
187regulation of cofactor metabolic process (GO:0051193)2.23406162
188regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.23188097
189cytochrome complex assembly (GO:0017004)2.22034956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.44826587
2GBX2_23144817_ChIP-Seq_PC3_Human3.31461127
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05367121
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.99350460
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.88052856
6TAF15_26573619_Chip-Seq_HEK293_Human2.65984787
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45064573
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.34939229
9FUS_26573619_Chip-Seq_HEK293_Human2.34454852
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.30673488
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29243815
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27057406
13REST_21632747_ChIP-Seq_MESCs_Mouse2.16720084
14* EST1_17652178_ChIP-ChIP_JURKAT_Human2.13795943
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13790120
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12063025
17* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09500644
18ELK1_19687146_ChIP-ChIP_HELA_Human2.08648674
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01097413
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00067279
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98602664
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98351290
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.97695440
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97573973
25ZNF274_21170338_ChIP-Seq_K562_Hela1.95706431
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.94100280
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84931614
28VDR_22108803_ChIP-Seq_LS180_Human1.84743999
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81718668
30E2F7_22180533_ChIP-Seq_HELA_Human1.80826886
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77575883
32RNF2_27304074_Chip-Seq_NSC_Mouse1.75961418
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.72492878
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71498701
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71046759
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69141916
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66956591
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65509565
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65509565
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.64192467
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62554633
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.62492972
43* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61792004
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61385238
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60997215
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60915001
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.59472360
48P300_19829295_ChIP-Seq_ESCs_Human1.59139276
49SMAD4_21799915_ChIP-Seq_A2780_Human1.55358047
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52900019
51ER_23166858_ChIP-Seq_MCF-7_Human1.52633927
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.51612331
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51480751
54SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51332852
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.50459384
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50413828
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45185532
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42942503
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.42685566
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42221003
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41838804
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41205876
63* EWS_26573619_Chip-Seq_HEK293_Human1.36014711
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.34678205
65SOX9_26525672_Chip-Seq_HEART_Mouse1.32220910
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31633538
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28570626
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28284861
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25402276
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25261577
71MYC_18940864_ChIP-ChIP_HL60_Human1.24145948
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23272774
73VDR_23849224_ChIP-Seq_CD4+_Human1.23230412
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22050589
75FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21716273
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21470302
77BCAT_22108803_ChIP-Seq_LS180_Human1.21351518
78KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19006903
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18385719
80TCF4_23295773_ChIP-Seq_U87_Human1.18222490
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.17407969
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.17200190
83FOXM1_23109430_ChIP-Seq_U2OS_Human1.17044111
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16845070
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16419064
86* NANOG_16153702_ChIP-ChIP_HESCs_Human1.16018770
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15540852
88* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14244912
89STAT3_23295773_ChIP-Seq_U87_Human1.12739358
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11647219
91DROSHA_22980978_ChIP-Seq_HELA_Human1.11432904
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10889636
93AR_21909140_ChIP-Seq_LNCAP_Human1.10371861
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.09730376
95* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09585827
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.08380307
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07927158
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.07623466
99* SOX2_16153702_ChIP-ChIP_HESCs_Human1.07501148
100JUN_21703547_ChIP-Seq_K562_Human1.07319764
101ETS1_20019798_ChIP-Seq_JURKAT_Human1.07213975
102P53_22387025_ChIP-Seq_ESCs_Mouse1.06216794
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.06143975
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05740477
105NANOG_19829295_ChIP-Seq_ESCs_Human1.04318330
106SOX2_19829295_ChIP-Seq_ESCs_Human1.04318330
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03967401
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03967401
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03171565
110* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03070208
111CRX_20693478_ChIP-Seq_RETINA_Mouse1.02415634
112TCF4_22108803_ChIP-Seq_LS180_Human1.02199047
113RUNX2_22187159_ChIP-Seq_PCA_Human1.01347744
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99893876
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99673632
116SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99585994
117AR_25329375_ChIP-Seq_VCAP_Human0.99501158
118FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99196000
119* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99049685
120* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98767608
121PIAS1_25552417_ChIP-Seq_VCAP_Human0.98742671
122YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98718489
123POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.98716512
124IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98612727
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97699940
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97456045
127CMYC_18555785_Chip-Seq_ESCs_Mouse0.97455925
128E2F1_18555785_Chip-Seq_ESCs_Mouse0.97437054
129CBP_20019798_ChIP-Seq_JUKART_Human0.97412850
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97412850
131P300_18555785_Chip-Seq_ESCs_Mouse0.97288227
132IGF1R_20145208_ChIP-Seq_DFB_Human0.96670111
133FLI1_21867929_ChIP-Seq_TH2_Mouse0.96523736
134NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95707047
135REST_19997604_ChIP-ChIP_NEURONS_Mouse0.95378357
136TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95167677
137E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94877428
138CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94767049
139PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94749869
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92741129
141SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.92444345
142HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91646235
143SMAD3_21741376_ChIP-Seq_ESCs_Human0.91436014
144POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91104412
145* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90813735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.53669956
2MP0005410_abnormal_fertilization3.37265621
3MP0004859_abnormal_synaptic_plasticity3.35861231
4MP0003122_maternal_imprinting3.28890870
5MP0002102_abnormal_ear_morphology2.94601587
6MP0003635_abnormal_synaptic_transmissio2.87838787
7MP0008877_abnormal_DNA_methylation2.70872673
8MP0009046_muscle_twitch2.49258004
9MP0009745_abnormal_behavioral_response2.47817067
10MP0002064_seizures2.42113374
11MP0008058_abnormal_DNA_repair2.38147601
12MP0001529_abnormal_vocalization2.34223725
13MP0002063_abnormal_learning/memory/cond2.33793328
14MP0003787_abnormal_imprinting2.29898636
15MP0004270_analgesia2.29479252
16MP0003890_abnormal_embryonic-extraembry2.25061691
17MP0002272_abnormal_nervous_system2.19916868
18MP0003123_paternal_imprinting2.18156253
19MP0002572_abnormal_emotion/affect_behav2.16524192
20MP0003121_genomic_imprinting2.14563243
21MP0010094_abnormal_chromosome_stability2.07918052
22MP0001968_abnormal_touch/_nociception2.06784811
23MP0006276_abnormal_autonomic_nervous2.00304654
24MP0000778_abnormal_nervous_system1.98537393
25MP0001486_abnormal_startle_reflex1.92395604
26MP0006292_abnormal_olfactory_placode1.90739160
27MP0005623_abnormal_meninges_morphology1.80937864
28MP0002734_abnormal_mechanical_nocicepti1.78968224
29MP0002736_abnormal_nociception_after1.76477714
30MP0001905_abnormal_dopamine_level1.73575048
31MP0001440_abnormal_grooming_behavior1.73054037
32MP0003698_abnormal_male_reproductive1.69763945
33MP0000372_irregular_coat_pigmentation1.64536024
34MP0008789_abnormal_olfactory_epithelium1.60799951
35MP0002067_abnormal_sensory_capabilities1.56997870
36MP0005423_abnormal_somatic_nervous1.54969901
37MP0002184_abnormal_innervation1.53145970
38MP0003937_abnormal_limbs/digits/tail_de1.46391038
39MP0003693_abnormal_embryo_hatching1.46218795
40MP0001188_hyperpigmentation1.44723092
41MP0005253_abnormal_eye_physiology1.43139549
42MP0005499_abnormal_olfactory_system1.43080707
43MP0005394_taste/olfaction_phenotype1.43080707
44MP0003718_maternal_effect1.41990054
45MP0005386_behavior/neurological_phenoty1.39832211
46MP0004924_abnormal_behavior1.39832211
47MP0001501_abnormal_sleep_pattern1.39095853
48MP0003119_abnormal_digestive_system1.38269019
49MP0000955_abnormal_spinal_cord1.38118489
50MP0005551_abnormal_eye_electrophysiolog1.37108672
51MP0002735_abnormal_chemical_nociception1.36606320
52MP0002733_abnormal_thermal_nociception1.34966369
53MP0002233_abnormal_nose_morphology1.34388737
54MP0001929_abnormal_gametogenesis1.33967520
55MP0004215_abnormal_myocardial_fiber1.33033503
56MP0003941_abnormal_skin_development1.32651586
57MP0001293_anophthalmia1.32566976
58MP0002557_abnormal_social/conspecific_i1.32208594
59MP0003567_abnormal_fetal_cardiomyocyte1.31787846
60MP0002653_abnormal_ependyma_morphology1.31329303
61MP0002822_catalepsy1.30114684
62MP0000516_abnormal_urinary_system1.29339971
63MP0005367_renal/urinary_system_phenotyp1.29339971
64MP0000751_myopathy1.28377959
65MP0003195_calcinosis1.27795377
66MP0001970_abnormal_pain_threshold1.27379333
67MP0008932_abnormal_embryonic_tissue1.26197849
68MP0004811_abnormal_neuron_physiology1.26022600
69MP0009697_abnormal_copulation1.25847848
70MP0004957_abnormal_blastocyst_morpholog1.24853568
71MP0005646_abnormal_pituitary_gland1.23934315
72MP0002882_abnormal_neuron_morphology1.23138105
73MP0006054_spinal_hemorrhage1.22778842
74MP0003111_abnormal_nucleus_morphology1.21089827
75MP0001984_abnormal_olfaction1.19444466
76MP0005248_abnormal_Harderian_gland1.19135830
77MP0000537_abnormal_urethra_morphology1.18706718
78MP0005084_abnormal_gallbladder_morpholo1.16482347
79MP0002066_abnormal_motor_capabilities/c1.16406970
80MP0002152_abnormal_brain_morphology1.15118429
81MP0005171_absent_coat_pigmentation1.13514653
82MP0001485_abnormal_pinna_reflex1.13064732
83MP0004142_abnormal_muscle_tone1.12911987
84MP0004145_abnormal_muscle_electrophysio1.11339658
85MP0002090_abnormal_vision1.10926612
86MP0003136_yellow_coat_color1.09554956
87MP0004742_abnormal_vestibular_system1.07582067
88MP0003755_abnormal_palate_morphology1.06630737
89MP0008569_lethality_at_weaning1.05863383
90MP0002210_abnormal_sex_determination1.05750955
91MP0000049_abnormal_middle_ear1.03975899
92MP0000920_abnormal_myelination1.03848248
93MP0009780_abnormal_chondrocyte_physiolo1.03397330
94MP0004885_abnormal_endolymph1.02154993
95MP0000631_abnormal_neuroendocrine_gland1.01360561
96MP0003077_abnormal_cell_cycle0.99008267
97MP0005645_abnormal_hypothalamus_physiol0.98563695
98MP0000647_abnormal_sebaceous_gland0.98464246
99MP0002234_abnormal_pharynx_morphology0.97136816
100MP0001286_abnormal_eye_development0.95565340
101MP0002909_abnormal_adrenal_gland0.95504258
102MP0003861_abnormal_nervous_system0.95364432
103MP0001963_abnormal_hearing_physiology0.94988599
104MP0003385_abnormal_body_wall0.94372937
105MP0003786_premature_aging0.93862224
106MP0002282_abnormal_trachea_morphology0.92747929
107MP0004134_abnormal_chest_morphology0.92702611
108MP0009703_decreased_birth_body0.91283329
109MP0004233_abnormal_muscle_weight0.91161099
110MP0002837_dystrophic_cardiac_calcinosis0.90807963
111MP0005503_abnormal_tendon_morphology0.89953747
112MP0005409_darkened_coat_color0.89290133
113MP0003329_amyloid_beta_deposits0.88989749
114MP0006072_abnormal_retinal_apoptosis0.88674869
115MP0002161_abnormal_fertility/fecundity0.88431679
116MP0003632_abnormal_nervous_system0.86632457
117MP0005187_abnormal_penis_morphology0.86628799
118MP0001145_abnormal_male_reproductive0.86260902
119MP0008057_abnormal_DNA_replication0.86077586
120MP0003137_abnormal_impulse_conducting0.85914481
121MP0003634_abnormal_glial_cell0.85120669
122MP0000534_abnormal_ureter_morphology0.85026620
123MP0003283_abnormal_digestive_organ0.84547204
124MP0008995_early_reproductive_senescence0.83035790
125MP0003011_delayed_dark_adaptation0.82976160
126MP0002752_abnormal_somatic_nervous0.82916958
127MP0002084_abnormal_developmental_patter0.82880225
128MP0005391_vision/eye_phenotype0.82203855
129MP0006035_abnormal_mitochondrial_morpho0.80254506
130MP0002160_abnormal_reproductive_system0.79991481
131MP0004085_abnormal_heartbeat0.78897234
132MP0004147_increased_porphyrin_level0.78566889
133MP0008007_abnormal_cellular_replicative0.78348310
134MP0000013_abnormal_adipose_tissue0.77515900
135MP0002751_abnormal_autonomic_nervous0.77265527
136MP0003942_abnormal_urinary_system0.76834793
137MP0002229_neurodegeneration0.76670901
138MP0003631_nervous_system_phenotype0.75834498
139MP0003879_abnormal_hair_cell0.75388535
140MP0004133_heterotaxia0.74909800
141MP0000653_abnormal_sex_gland0.73221490
142MP0001299_abnormal_eye_distance/0.72881086
143MP0009250_abnormal_appendicular_skeleto0.71081449
144* MP0001943_abnormal_respiration0.69794996
145MP0002938_white_spotting0.69178122
146MP0001177_atelectasis0.68402515
147MP0000026_abnormal_inner_ear0.68385458
148MP0002638_abnormal_pupillary_reflex0.67518906
149MP0004036_abnormal_muscle_relaxation0.66564327

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)4.95860276
2Absent/shortened dynein arms (HP:0200106)4.95860276
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.60628478
4Focal motor seizures (HP:0011153)4.16972121
5Abnormal respiratory motile cilium morphology (HP:0005938)3.76851060
6Abnormal respiratory epithelium morphology (HP:0012253)3.76851060
7Abnormal respiratory motile cilium physiology (HP:0012261)3.74604493
8Atonic seizures (HP:0010819)3.58011999
9Abnormal ciliary motility (HP:0012262)3.43699194
10Rhinitis (HP:0012384)3.36332844
11Volvulus (HP:0002580)3.36202327
12Intestinal atresia (HP:0011100)3.06314993
13Epileptic encephalopathy (HP:0200134)3.02341235
14Focal seizures (HP:0007359)2.93714363
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.92469073
16Degeneration of the lateral corticospinal tracts (HP:0002314)2.92469073
17Medial flaring of the eyebrow (HP:0010747)2.91379259
18Myokymia (HP:0002411)2.82881736
19Methylmalonic acidemia (HP:0002912)2.77398540
20Gait imbalance (HP:0002141)2.74787216
21Colon cancer (HP:0003003)2.74357434
22Acute necrotizing encephalopathy (HP:0006965)2.74209367
23Pheochromocytoma (HP:0002666)2.70721016
24Progressive cerebellar ataxia (HP:0002073)2.60790276
25Congenital primary aphakia (HP:0007707)2.59808905
26Visual hallucinations (HP:0002367)2.58887056
27Infertility (HP:0000789)2.53839400
28Limb dystonia (HP:0002451)2.52139316
29Amyotrophic lateral sclerosis (HP:0007354)2.50411222
30Pancreatic fibrosis (HP:0100732)2.50045979
31Abnormal lung lobation (HP:0002101)2.48114659
32Insidious onset (HP:0003587)2.47275505
33Termporal pattern (HP:0011008)2.47275505
34Hyperventilation (HP:0002883)2.46581429
35Genital tract atresia (HP:0001827)2.46196464
36Neuroendocrine neoplasm (HP:0100634)2.46099148
37Vaginal atresia (HP:0000148)2.45626758
38True hermaphroditism (HP:0010459)2.44514660
39Pancreatic cysts (HP:0001737)2.43879516
40Abnormality of the lower motor neuron (HP:0002366)2.43390206
41Abnormality of the labia minora (HP:0012880)2.42612557
42Abnormal mitochondria in muscle tissue (HP:0008316)2.41116317
43Abnormality of the corticospinal tract (HP:0002492)2.38965158
44Nephronophthisis (HP:0000090)2.38469242
45Progressive macrocephaly (HP:0004481)2.38138041
46Broad-based gait (HP:0002136)2.33193761
47Ependymoma (HP:0002888)2.31602564
48Increased serum pyruvate (HP:0003542)2.30816740
49Abnormality of glycolysis (HP:0004366)2.30816740
50Meckel diverticulum (HP:0002245)2.29535225
51Nephrogenic diabetes insipidus (HP:0009806)2.28716378
52Absence seizures (HP:0002121)2.28553320
53Cerebral inclusion bodies (HP:0100314)2.26741109
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.23509426
55Hypothermia (HP:0002045)2.23098191
56Abnormality of the ileum (HP:0001549)2.21999026
57Abnormality of chromosome stability (HP:0003220)2.21034625
58Bifid tongue (HP:0010297)2.21021698
59Chronic bronchitis (HP:0004469)2.19277304
60Shoulder girdle muscle weakness (HP:0003547)2.16950402
61Septo-optic dysplasia (HP:0100842)2.15198546
62Neoplasm of the adrenal cortex (HP:0100641)2.10780689
63Aqueductal stenosis (HP:0002410)2.10720881
64Dialeptic seizures (HP:0011146)2.10694881
65Molar tooth sign on MRI (HP:0002419)2.10591116
66Abnormality of midbrain morphology (HP:0002418)2.10591116
67Neurofibrillary tangles (HP:0002185)2.09716973
68Abnormal hair whorl (HP:0010721)2.07082725
69Gaze-evoked nystagmus (HP:0000640)2.05372951
70Amblyopia (HP:0000646)2.04021326
71Neoplasm of the adrenal gland (HP:0100631)2.03963936
72Astrocytoma (HP:0009592)2.03295423
73Abnormality of the astrocytes (HP:0100707)2.03295423
74Hepatoblastoma (HP:0002884)2.02986213
75Poor suck (HP:0002033)2.02061762
76Leukodystrophy (HP:0002415)2.00701577
77Hyperglycinemia (HP:0002154)1.99677799
78Glioma (HP:0009733)1.99398273
79Specific learning disability (HP:0001328)1.98684436
80Optic nerve hypoplasia (HP:0000609)1.97399111
81Oligodactyly (hands) (HP:0001180)1.96516036
82Cortical dysplasia (HP:0002539)1.95899087
83Ankle clonus (HP:0011448)1.95609750
84Methylmalonic aciduria (HP:0012120)1.95274404
85Hyperinsulinemic hypoglycemia (HP:0000825)1.94342173
86Impaired vibration sensation in the lower limbs (HP:0002166)1.93395540
87Febrile seizures (HP:0002373)1.92016699
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90634641
89Hypoglycemic coma (HP:0001325)1.87978908
90Abnormality of the duodenum (HP:0002246)1.87732519
91Poor coordination (HP:0002370)1.87360724
92Supranuclear gaze palsy (HP:0000605)1.87154554
93Spastic gait (HP:0002064)1.87045188
94Labial hypoplasia (HP:0000066)1.86862472
95Aplasia/Hypoplasia of the tongue (HP:0010295)1.86806270
96Hypoplastic female external genitalia (HP:0012815)1.85501833
97Gonadotropin excess (HP:0000837)1.85161511
98Urinary urgency (HP:0000012)1.84864580
99Hypoglycemic seizures (HP:0002173)1.84226969
100Renal hypoplasia (HP:0000089)1.82909840
101Abnormality of dentin (HP:0010299)1.82265560
102Truncal ataxia (HP:0002078)1.82095970
103Embryonal renal neoplasm (HP:0011794)1.80994201
104Abnormality of vitamin B metabolism (HP:0004340)1.80556072
105Delayed gross motor development (HP:0002194)1.80333592
106Pancreatic islet-cell hyperplasia (HP:0004510)1.79608043
107Sensory axonal neuropathy (HP:0003390)1.79213790
108Absent septum pellucidum (HP:0001331)1.79182929
109Broad foot (HP:0001769)1.79165396
110Failure to thrive in infancy (HP:0001531)1.78810176
111Narrow forehead (HP:0000341)1.78720864
112Gastrointestinal atresia (HP:0002589)1.78341873
113Rimmed vacuoles (HP:0003805)1.77626238
114Abnormality of the metopic suture (HP:0005556)1.77512937
115Nephroblastoma (Wilms tumor) (HP:0002667)1.77036285
116Mitochondrial inheritance (HP:0001427)1.76831217
117Abnormality of methionine metabolism (HP:0010901)1.76483905
118Small intestinal stenosis (HP:0012848)1.76099635
119Duodenal stenosis (HP:0100867)1.76099635
120Neoplasm of the peripheral nervous system (HP:0100007)1.75516330
121Increased CSF lactate (HP:0002490)1.74309330
122Sloping forehead (HP:0000340)1.73935242
123Absent epiphyses (HP:0010577)1.73636405
124Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73636405
125Acute encephalopathy (HP:0006846)1.73285856
126Generalized tonic-clonic seizures (HP:0002069)1.73110327
127Aplasia/Hypoplasia of the lens (HP:0008063)1.72970323
128Chromsome breakage (HP:0040012)1.72846541
129Preaxial hand polydactyly (HP:0001177)1.72080623
130Progressive inability to walk (HP:0002505)1.70307325
131Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70088753
132Dysmetria (HP:0001310)1.69951112
133Hypoplasia of the fovea (HP:0007750)1.69258581
134Aplasia/Hypoplasia of the fovea (HP:0008060)1.69258581
135Abnormality of the fovea (HP:0000493)1.68380365
136Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68225922
137Increased hepatocellular lipid droplets (HP:0006565)1.67926706
138Scrotal hypoplasia (HP:0000046)1.67761074
139Absent speech (HP:0001344)1.67548884
140Rhabdomyosarcoma (HP:0002859)1.67422502
141Aplasia/Hypoplasia of the brainstem (HP:0007362)1.67087998
142Hypoplasia of the brainstem (HP:0002365)1.67087998
143Decreased testicular size (HP:0008734)1.67022215
144Dandy-Walker malformation (HP:0001305)1.66581710
145Cerebral hypomyelination (HP:0006808)1.66267056
146Astigmatism (HP:0000483)1.66151520
147Chromosomal breakage induced by crosslinking agents (HP:0003221)1.65176548
148Delusions (HP:0000746)1.63506580
149Anxiety (HP:0000739)1.63243272
150Hypoventilation (HP:0002791)1.63070377
151Hypoplastic pelvis (HP:0008839)1.62472167
152Anencephaly (HP:0002323)1.62262588
153Retinal dysplasia (HP:0007973)1.61681255
154Depression (HP:0000716)1.61638771
155Abnormality of glycine metabolism (HP:0010895)1.61499603
156Abnormality of serine family amino acid metabolism (HP:0010894)1.61499603
157Abnormality of the preputium (HP:0100587)1.61007371
158Abnormality of the septum pellucidum (HP:0007375)1.60773163
159Median cleft lip (HP:0000161)1.60544473
160Lissencephaly (HP:0001339)1.60120695
161Drooling (HP:0002307)1.58872789
162Excessive salivation (HP:0003781)1.58872789
163Abnormality of the renal medulla (HP:0100957)1.58012548
164Action tremor (HP:0002345)1.57729551
165Abnormal eating behavior (HP:0100738)1.57455351
166Postaxial hand polydactyly (HP:0001162)1.57286844
167Protruding tongue (HP:0010808)1.56309372
168Supernumerary spleens (HP:0009799)1.54605671
169Hemiparesis (HP:0001269)1.53689420
170Widely spaced teeth (HP:0000687)1.52983740
171Epileptiform EEG discharges (HP:0011182)1.52331217
172Polyphagia (HP:0002591)1.51951336

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.40724144
2TRIM283.62197089
3CASK3.06222617
4PDK42.89923851
5PDK32.89923851
6NTRK32.82879687
7MAP3K42.73826704
8STK392.61356460
9FRK2.61235710
10PLK22.40460917
11MAP2K72.26691698
12MAP3K122.22414662
13EPHA42.10664818
14BCR2.09016196
15MAP4K22.01918574
16MINK12.01716803
17PRKD31.99977150
18EIF2AK31.97075042
19NEK11.92443127
20UHMK11.87842251
21NUAK11.86035339
22OXSR11.84706018
23TSSK61.78710018
24PLK41.74026806
25MST41.72015624
26WNK41.71219697
27PDK21.69996881
28TTK1.66011984
29ACVR1B1.65801352
30MARK11.64206399
31CDK191.59267180
32BRSK21.57184921
33MAPK131.55570989
34PTK2B1.50887852
35MAP2K41.36301484
36TYRO31.36189825
37KSR11.35125768
38EIF2AK11.34830362
39TESK11.32213643
40TNIK1.30870766
41MAP3K91.25424035
42ZAK1.24567981
43NTRK21.20547291
44LIMK11.18924946
45WNK11.14948834
46ICK1.12836076
47CDK141.12652341
48PLK11.12400614
49PINK11.12154403
50STK38L1.10926416
51MKNK11.09323257
52PAK61.07946407
53PBK1.06280715
54CDK181.06218588
55WNK31.04656123
56CCNB11.01804631
57NTRK11.01111413
58PLK30.99497866
59CDK150.97972249
60CAMK2B0.97921528
61PRKCG0.97865822
62DAPK10.97709219
63PASK0.96854619
64CDK50.96037730
65CSNK1G30.95801487
66VRK10.95310520
67VRK20.94322620
68GRK10.93665355
69NME10.91577890
70CAMK2A0.88541450
71GRK50.86989235
72DAPK20.86550915
73CDK11A0.85472098
74CSNK1G20.85415368
75SIK30.85118139
76ROCK20.81081753
77BRSK10.80658581
78AKT30.79657742
79MAPKAPK50.79448766
80CDC70.77022213
81TAF10.75896276
82ERBB30.75197582
83PRPF4B0.75040111
84NEK60.73753709
85STK30.73031414
86MKNK20.72240939
87BMPR1B0.71648698
88TGFBR10.71187720
89FGFR20.70187820
90SGK2230.69841540
91SGK4940.69841540
92EIF2AK20.69731811
93GRK70.67867915
94DYRK1A0.66727174
95KSR20.65807770
96ARAF0.61845173
97ATM0.60877327
98ATR0.60632241
99FGR0.59750809
100PAK30.59129490
101CSNK1A1L0.58227340
102INSRR0.54713806
103ERBB40.53670200
104CAMK2D0.53511287
105ADRBK20.52872290
106FES0.52519137
107RIPK40.51537052
108BCKDK0.51452430
109BMPR20.51292490
110CSNK1G10.51226405
111PRKCE0.49399085
112PHKG20.48559101
113PHKG10.48559101
114MYLK0.48336450
115BUB10.47552068
116DYRK30.47089020
117CAMK1G0.46355708
118NLK0.46208809
119ADRBK10.43861623
120CSNK1E0.43809088
121WEE10.42853149
122CHEK20.42647130
123BRD40.40403938
124CDK30.38663000
125FER0.37095929
126STK160.36670400
127SRPK10.36010332
128PKN10.35528938
129MAP3K20.34591083
130FGFR10.34344047
131MAPK100.34232475
132CSNK1A10.33686904
133AURKB0.33234768
134PRKDC0.33230831
135CAMK2G0.32843126
136DYRK20.32645158
137CSNK1D0.32440173
138PRKACB0.31577939
139ROCK10.31413240
140CSNK2A10.31301893
141FLT30.29941102
142YES10.27666057
143PRKACA0.27409177
144SGK10.27113829

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.22061268
2Non-homologous end-joining_Homo sapiens_hsa034503.11064530
3Synaptic vesicle cycle_Homo sapiens_hsa047212.89711547
4Oxidative phosphorylation_Homo sapiens_hsa001902.56779208
5Collecting duct acid secretion_Homo sapiens_hsa049662.55931634
6Amphetamine addiction_Homo sapiens_hsa050312.51535378
7Propanoate metabolism_Homo sapiens_hsa006402.41981629
8Long-term potentiation_Homo sapiens_hsa047202.40207176
9Mismatch repair_Homo sapiens_hsa034302.37039135
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22833701
11Parkinsons disease_Homo sapiens_hsa050122.17780226
12Dopaminergic synapse_Homo sapiens_hsa047282.09442723
13Vibrio cholerae infection_Homo sapiens_hsa051102.05117640
14GABAergic synapse_Homo sapiens_hsa047272.04349359
15Circadian entrainment_Homo sapiens_hsa047132.02416604
16Steroid biosynthesis_Homo sapiens_hsa001001.97365103
17Fanconi anemia pathway_Homo sapiens_hsa034601.95527860
18Homologous recombination_Homo sapiens_hsa034401.93231889
19Morphine addiction_Homo sapiens_hsa050321.91591580
20Huntingtons disease_Homo sapiens_hsa050161.90929435
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90174160
22Glutamatergic synapse_Homo sapiens_hsa047241.88203758
23Alzheimers disease_Homo sapiens_hsa050101.86185153
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77466200
25Olfactory transduction_Homo sapiens_hsa047401.76874767
26Oocyte meiosis_Homo sapiens_hsa041141.75689194
27Cardiac muscle contraction_Homo sapiens_hsa042601.71866869
28Vitamin B6 metabolism_Homo sapiens_hsa007501.69429324
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69074083
30Serotonergic synapse_Homo sapiens_hsa047261.68570800
31Taste transduction_Homo sapiens_hsa047421.67213968
32Long-term depression_Homo sapiens_hsa047301.65686147
33Butanoate metabolism_Homo sapiens_hsa006501.65636927
34Cocaine addiction_Homo sapiens_hsa050301.64163235
35Renin secretion_Homo sapiens_hsa049241.54866417
36Proteasome_Homo sapiens_hsa030501.52702605
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48358057
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48276420
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47565353
40DNA replication_Homo sapiens_hsa030301.43614726
41Axon guidance_Homo sapiens_hsa043601.41749924
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39449379
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37801019
44Cell cycle_Homo sapiens_hsa041101.36751437
45Insulin secretion_Homo sapiens_hsa049111.35686487
46Salivary secretion_Homo sapiens_hsa049701.33089599
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32875362
48Cholinergic synapse_Homo sapiens_hsa047251.31275916
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.30018212
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.29944152
51Selenocompound metabolism_Homo sapiens_hsa004501.28866089
52Base excision repair_Homo sapiens_hsa034101.28371873
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25853945
54Nucleotide excision repair_Homo sapiens_hsa034201.24288033
55Gastric acid secretion_Homo sapiens_hsa049711.22811629
56Calcium signaling pathway_Homo sapiens_hsa040201.22300221
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21574072
58Oxytocin signaling pathway_Homo sapiens_hsa049211.21132503
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18675105
60Protein export_Homo sapiens_hsa030601.17386538
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16451340
62Gap junction_Homo sapiens_hsa045401.15479183
63mRNA surveillance pathway_Homo sapiens_hsa030151.09958312
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09603841
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09263324
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02611585
67Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01080429
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00101599
69Estrogen signaling pathway_Homo sapiens_hsa049150.99338004
70Basal transcription factors_Homo sapiens_hsa030220.97310200
71Melanogenesis_Homo sapiens_hsa049160.96556375
72Folate biosynthesis_Homo sapiens_hsa007900.93699588
73Dorso-ventral axis formation_Homo sapiens_hsa043200.92226949
74Regulation of autophagy_Homo sapiens_hsa041400.89786190
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89532031
76Hedgehog signaling pathway_Homo sapiens_hsa043400.88688208
77Purine metabolism_Homo sapiens_hsa002300.87690319
78beta-Alanine metabolism_Homo sapiens_hsa004100.87468569
79Spliceosome_Homo sapiens_hsa030400.85815175
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85708043
81Fatty acid metabolism_Homo sapiens_hsa012120.84400302
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84198956
83GnRH signaling pathway_Homo sapiens_hsa049120.82346646
84cAMP signaling pathway_Homo sapiens_hsa040240.80941835
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.80010347
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79923473
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79768359
88RNA transport_Homo sapiens_hsa030130.78244500
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77725785
90Wnt signaling pathway_Homo sapiens_hsa043100.76623332
91Peroxisome_Homo sapiens_hsa041460.76394405
92Circadian rhythm_Homo sapiens_hsa047100.75445753
93Glucagon signaling pathway_Homo sapiens_hsa049220.74095514
94One carbon pool by folate_Homo sapiens_hsa006700.73571367
95TGF-beta signaling pathway_Homo sapiens_hsa043500.70483397
96Pyrimidine metabolism_Homo sapiens_hsa002400.68653844
97Glutathione metabolism_Homo sapiens_hsa004800.67234397
98Alcoholism_Homo sapiens_hsa050340.66936986
99Sulfur metabolism_Homo sapiens_hsa009200.66935484
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66186616
101Tryptophan metabolism_Homo sapiens_hsa003800.65216911
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64863476
103p53 signaling pathway_Homo sapiens_hsa041150.63384412
104ErbB signaling pathway_Homo sapiens_hsa040120.63279426
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63142434
106Ether lipid metabolism_Homo sapiens_hsa005650.62079810
107Thyroid hormone synthesis_Homo sapiens_hsa049180.62052485
108Glioma_Homo sapiens_hsa052140.61920710
109Pyruvate metabolism_Homo sapiens_hsa006200.61138952
110Carbon metabolism_Homo sapiens_hsa012000.60739212
111Renal cell carcinoma_Homo sapiens_hsa052110.59852122
112Phagosome_Homo sapiens_hsa041450.58918098
113Metabolic pathways_Homo sapiens_hsa011000.57981076
114Dilated cardiomyopathy_Homo sapiens_hsa054140.57814085
115Fatty acid degradation_Homo sapiens_hsa000710.57732427
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56539788
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56450600
118Nitrogen metabolism_Homo sapiens_hsa009100.56024746
119Rheumatoid arthritis_Homo sapiens_hsa053230.54961674
120Tight junction_Homo sapiens_hsa045300.54268773
121Phototransduction_Homo sapiens_hsa047440.54007642
122Type I diabetes mellitus_Homo sapiens_hsa049400.51909526
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51706459
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51372463
125MAPK signaling pathway_Homo sapiens_hsa040100.51316621
126Hippo signaling pathway_Homo sapiens_hsa043900.50640384
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49771304
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49683303
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49550523
130Endocytosis_Homo sapiens_hsa041440.46704022
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46627836
132Ras signaling pathway_Homo sapiens_hsa040140.45810277
133Type II diabetes mellitus_Homo sapiens_hsa049300.43779956
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43080662
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42161725
136RNA degradation_Homo sapiens_hsa030180.40643986
137RNA polymerase_Homo sapiens_hsa030200.40540505
138Arginine and proline metabolism_Homo sapiens_hsa003300.40231896
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39182223
140Biosynthesis of amino acids_Homo sapiens_hsa012300.38622046
141Fatty acid elongation_Homo sapiens_hsa000620.38293354
142Caffeine metabolism_Homo sapiens_hsa002320.37875222
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37395210
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37367393
145Basal cell carcinoma_Homo sapiens_hsa052170.37306843
146Pancreatic secretion_Homo sapiens_hsa049720.36519569
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.36230866
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34642536
149Rap1 signaling pathway_Homo sapiens_hsa040150.34042612
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32436234
151Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31784137
152Colorectal cancer_Homo sapiens_hsa052100.31015916

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