ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.40362219
2	cytidine deamination (GO:0009972)	4.93029345
3	cytidine metabolic process (GO:0046087)	4.93029345
4	cytidine catabolic process (GO:0006216)	4.93029345
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.81247109
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.20619545
7	kynurenine metabolic process (GO:0070189)	3.80729071
8	chromatin remodeling at centromere (GO:0031055)	3.78957795
9	proteasome assembly (GO:0043248)	3.75088489
10	terpenoid biosynthetic process (GO:0016114)	3.71771596
11	tryptophan catabolic process (GO:0006569)	3.64774493
12	indole-containing compound catabolic process (GO:0042436)	3.64774493
13	indolalkylamine catabolic process (GO:0046218)	3.64774493
14	protein neddylation (GO:0045116)	3.64129090
15	DNA double-strand break processing (GO:0000729)	3.56943870
16	water-soluble vitamin biosynthetic process (GO:0042364)	3.54880447
17	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.54782364
18	CENP-A containing nucleosome assembly (GO:0034080)	3.52658682
19	protein polyglutamylation (GO:0018095)	3.51139078
20	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.48127779
21	DNA unwinding involved in DNA replication (GO:0006268)	3.46977549
22	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.44056571
23	mannosylation (GO:0097502)	3.42849254
24	DNA strand elongation involved in DNA replication (GO:0006271)	3.36215717
25	fucose catabolic process (GO:0019317)	3.35539183
26	L-fucose metabolic process (GO:0042354)	3.35539183
27	L-fucose catabolic process (GO:0042355)	3.35539183
28	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.34668416
29	regulation of cellular amino acid metabolic process (GO:0006521)	3.32175408
30	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.27295918
31	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.26878424
32	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.26703728
33	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.26703728
34	DNA catabolic process, exonucleolytic (GO:0000738)	3.21615127
35	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.19374523
36	tryptophan metabolic process (GO:0006568)	3.17324518
37	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.16848856
38	response to pheromone (GO:0019236)	3.16293707
39	DNA demethylation (GO:0080111)	3.15352253
40	preassembly of GPI anchor in ER membrane (GO:0016254)	3.13037407
41	DNA strand elongation (GO:0022616)	3.12984671
42	regulation of cilium movement (GO:0003352)	3.12574769
43	protein deneddylation (GO:0000338)	3.11885916
44	negative regulation by host of viral transcription (GO:0043922)	3.11710079
45	cullin deneddylation (GO:0010388)	3.11424754
46	somite development (GO:0061053)	3.11171039
47	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.09027929
48	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.09027929
49	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.09027929
50	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.08678964
51	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.08678964
52	negative regulation of ligase activity (GO:0051352)	3.05045937
53	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.05045937
54	indolalkylamine metabolic process (GO:0006586)	3.04458171
55	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.02587667
56	rRNA modification (GO:0000154)	3.01283558
57	rRNA methylation (GO:0031167)	3.00167740
58	protein complex biogenesis (GO:0070271)	2.96461632
59	histone exchange (GO:0043486)	2.95936356
60	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.95295822
61	platelet dense granule organization (GO:0060155)	2.91946007
62	histone H2A acetylation (GO:0043968)	2.90388830
63	isoprenoid biosynthetic process (GO:0008299)	2.89214191
64	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.89063779
65	ATP synthesis coupled proton transport (GO:0015986)	2.89063779
66	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.88527337
67	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.88527337
68	behavioral response to nicotine (GO:0035095)	2.85302028
69	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.85174401
70	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.85122686
71	positive regulation of ligase activity (GO:0051351)	2.84094207
72	diterpenoid biosynthetic process (GO:0016102)	2.84061295
73	respiratory chain complex IV assembly (GO:0008535)	2.83986608
74	histone mRNA catabolic process (GO:0071044)	2.83656183
75	histone mRNA metabolic process (GO:0008334)	2.82874975
76	acrosome reaction (GO:0007340)	2.81162002
77	cytochrome complex assembly (GO:0017004)	2.80346146
78	GPI anchor metabolic process (GO:0006505)	2.79996292
79	regulation of meiosis I (GO:0060631)	2.75742959
80	chaperone-mediated protein transport (GO:0072321)	2.75448707
81	regulation of timing of cell differentiation (GO:0048505)	2.71833878
82	double-strand break repair via homologous recombination (GO:0000724)	2.70705510
83	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.70667255
84	righting reflex (GO:0060013)	2.70206089
85	recombinational repair (GO:0000725)	2.69745403
86	regulation of development, heterochronic (GO:0040034)	2.68351373
87	metallo-sulfur cluster assembly (GO:0031163)	2.67856512
88	iron-sulfur cluster assembly (GO:0016226)	2.67856512
89	mitochondrial respiratory chain complex assembly (GO:0033108)	2.66695545
90	DNA dealkylation (GO:0035510)	2.65182073
91	protein-cofactor linkage (GO:0018065)	2.64977747
92	regulation of mitotic spindle checkpoint (GO:1903504)	2.64311350
93	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.64311350
94	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)	2.62820070
95	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.62108749
96	termination of RNA polymerase III transcription (GO:0006386)	2.62108749
97	glycosphingolipid biosynthetic process (GO:0006688)	2.61616014
98	sequestering of actin monomers (GO:0042989)	2.61566077
99	GPI anchor biosynthetic process (GO:0006506)	2.59245764
100	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.57912908

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.08126041
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.93147668
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.43698310
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.19863222
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.11461050
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.95423809
7	VDR_22108803_ChIP-Seq_LS180_Human	2.84420522
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.84079857
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.81917476
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.74328428
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.61556556
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.51393159
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.37728752
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.24831921
15	EWS_26573619_Chip-Seq_HEK293_Human	2.23275979
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.14760331
17	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.10191015
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.06653077
19	FUS_26573619_Chip-Seq_HEK293_Human	2.00169135
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.97797975
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.94541950
22	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.91025366
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.90707106
24	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.87839767
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.86549275
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.82050816
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.81531548
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.76056910
29	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.73800035
30	P300_19829295_ChIP-Seq_ESCs_Human	1.73090265
31	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.69497168
32	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.68703084
33	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.67463584
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.66055912
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.64214078
36	GBX2_23144817_ChIP-Seq_PC3_Human	1.62354393
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.62069559
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.59277403
39	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.57103408
40	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.54068003
41	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.47663668
42	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46482836
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.46225448
44	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.41292019
45	ER_23166858_ChIP-Seq_MCF-7_Human	1.40376090
46	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.38929759
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.38667011
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.38460294
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38460294
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37793119
51	TAF15_26573619_Chip-Seq_HEK293_Human	1.37310034
52	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.32892953
53	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.32738965
54	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.26396467
55	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.25697083
56	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.25630091
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21880569
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21880569
59	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.19632615
60	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16524408
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15496072
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11006278
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10583412
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10583412
65	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09247767
66	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.09127869
67	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.09088964
68	DCP1A_22483619_ChIP-Seq_HELA_Human	1.07412312
69	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.06956711
70	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.06098077
71	BCAT_22108803_ChIP-Seq_LS180_Human	1.05868085
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03626714
73	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02738367
74	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02391149
75	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02246485
76	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.00697452
77	AR_25329375_ChIP-Seq_VCAP_Human	1.00095464
78	CIITA_25753668_ChIP-Seq_RAJI_Human	0.99798450
79	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.98374572
80	SMAD4_21799915_ChIP-Seq_A2780_Human	0.96945804
81	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96745203
82	RNF2_27304074_Chip-Seq_NSC_Mouse	0.96610641
83	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96355270
84	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.96102309
85	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.95452835
86	P53_22387025_ChIP-Seq_ESCs_Mouse	0.95259171
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95057181
88	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.94288099
89	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.94189259
90	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.93033098
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.92927236
92	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.92739294
93	P300_18555785_Chip-Seq_ESCs_Mouse	0.92165280
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.92055344
95	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.91908995
96	NCOR_22424771_ChIP-Seq_293T_Human	0.91280650
97	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.91038425
98	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.90856553
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.90044621
100	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.89977775

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.36708371
2	MP0002102_abnormal_ear_morphology	3.22326639
3	MP0008877_abnormal_DNA_methylation	3.20664196
4	MP0010094_abnormal_chromosome_stability	3.06322796
5	MP0008058_abnormal_DNA_repair	2.94289144
6	MP0009697_abnormal_copulation	2.79449237
7	MP0003880_abnormal_central_pattern	2.48517854
8	MP0008789_abnormal_olfactory_epithelium	2.25953309
9	MP0006072_abnormal_retinal_apoptosis	2.17612719
10	MP0000372_irregular_coat_pigmentation	2.11400609
11	MP0002736_abnormal_nociception_after	1.97093860
12	MP0001529_abnormal_vocalization	1.94843761
13	MP0005551_abnormal_eye_electrophysiolog	1.92933926
14	MP0003786_premature_aging	1.92677964
15	MP0005645_abnormal_hypothalamus_physiol	1.89852719
16	MP0006035_abnormal_mitochondrial_morpho	1.84074810
17	MP0001968_abnormal_touch/_nociception	1.83670382
18	MP0003718_maternal_effect	1.79510430
19	MP0005499_abnormal_olfactory_system	1.72219486
20	MP0005394_taste/olfaction_phenotype	1.72219486
21	MP0005671_abnormal_response_to	1.67214650
22	MP0003111_abnormal_nucleus_morphology	1.66092528
23	MP0002822_catalepsy	1.65867777
24	MP0005084_abnormal_gallbladder_morpholo	1.65095248
25	MP0006276_abnormal_autonomic_nervous	1.58597641
26	MP0005253_abnormal_eye_physiology	1.57451385
27	MP0004215_abnormal_myocardial_fiber	1.54888052
28	MP0003693_abnormal_embryo_hatching	1.53960628
29	MP0006036_abnormal_mitochondrial_physio	1.52009928
30	MP0002876_abnormal_thyroid_physiology	1.48795542
31	MP0000631_abnormal_neuroendocrine_gland	1.46700134
32	MP0008872_abnormal_physiological_respon	1.45794134
33	MP0000049_abnormal_middle_ear	1.42173671
34	MP0002138_abnormal_hepatobiliary_system	1.37329173
35	MP0001188_hyperpigmentation	1.25426135
36	MP0003567_abnormal_fetal_cardiomyocyte	1.25228632
37	MP0001905_abnormal_dopamine_level	1.23206117
38	MP0009046_muscle_twitch	1.22828308
39	MP0002210_abnormal_sex_determination	1.15141980
40	MP0001293_anophthalmia	1.14707107
41	MP0003937_abnormal_limbs/digits/tail_de	1.14683481
42	MP0008995_early_reproductive_senescence	1.14445350
43	MP0004142_abnormal_muscle_tone	1.13241116
44	MP0001929_abnormal_gametogenesis	1.12299143
45	MP0004147_increased_porphyrin_level	1.10499212
46	MP0002733_abnormal_thermal_nociception	1.08444835
47	MP0001485_abnormal_pinna_reflex	1.06230135
48	MP0005410_abnormal_fertilization	1.04966349
49	MP0002837_dystrophic_cardiac_calcinosis	1.04208058
50	MP0002909_abnormal_adrenal_gland	1.04082996
51	MP0002233_abnormal_nose_morphology	1.03370858
52	MP0005167_abnormal_blood-brain_barrier	1.03226848
53	MP0004145_abnormal_muscle_electrophysio	1.02533542
54	MP0003646_muscle_fatigue	1.02493766
55	MP0003186_abnormal_redox_activity	1.02268516
56	MP0003787_abnormal_imprinting	0.99230966
57	MP0003137_abnormal_impulse_conducting	0.98940924
58	MP0001764_abnormal_homeostasis	0.97932959
59	MP0000653_abnormal_sex_gland	0.96871316
60	MP0000639_abnormal_adrenal_gland	0.95392663
61	MP0004134_abnormal_chest_morphology	0.94649103
62	MP0000358_abnormal_cell_content/	0.94561331
63	MP0005195_abnormal_posterior_eye	0.94269713
64	MP0001177_atelectasis	0.93361456
65	MP0003806_abnormal_nucleotide_metabolis	0.92889617
66	MP0002234_abnormal_pharynx_morphology	0.92523458
67	MP0002272_abnormal_nervous_system	0.91821195
68	MP0003698_abnormal_male_reproductive	0.89414675
69	MP0003121_genomic_imprinting	0.89214955
70	MP0005386_behavior/neurological_phenoty	0.89158583
71	MP0004924_abnormal_behavior	0.89158583
72	MP0002735_abnormal_chemical_nociception	0.88723102
73	MP0001145_abnormal_male_reproductive	0.88519926
74	MP0001119_abnormal_female_reproductive	0.86175230
75	MP0005391_vision/eye_phenotype	0.85102759
76	MP0004957_abnormal_blastocyst_morpholog	0.85016701
77	MP0003119_abnormal_digestive_system	0.83178516
78	MP0008007_abnormal_cellular_replicative	0.82200842
79	MP0008932_abnormal_embryonic_tissue	0.81337775
80	MP0002751_abnormal_autonomic_nervous	0.81334008
81	MP0008057_abnormal_DNA_replication	0.79870216
82	MP0010386_abnormal_urinary_bladder	0.79767422
83	MP0003195_calcinosis	0.79254841
84	MP0000778_abnormal_nervous_system	0.79236516
85	MP0002752_abnormal_somatic_nervous	0.78987255
86	MP0009745_abnormal_behavioral_response	0.78144123
87	MP0002638_abnormal_pupillary_reflex	0.77543620
88	MP0002067_abnormal_sensory_capabilities	0.76995903
89	MP0000230_abnormal_systemic_arterial	0.76762970
90	MP0003077_abnormal_cell_cycle	0.76577725
91	MP0001486_abnormal_startle_reflex	0.75037601
92	MP0003938_abnormal_ear_development	0.75006761
93	MP0003011_delayed_dark_adaptation	0.74808766
94	MP0002160_abnormal_reproductive_system	0.73670622
95	MP0005389_reproductive_system_phenotype	0.73612189
96	MP0005646_abnormal_pituitary_gland	0.72710781
97	MP0004270_analgesia	0.69970374
98	MP0000566_synostosis	0.67780087
99	MP0002572_abnormal_emotion/affect_behav	0.67632983
100	MP0001984_abnormal_olfaction	0.67199482

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of B cell number (HP:0010975)	3.59894516
2	B lymphocytopenia (HP:0010976)	3.40353329
3	Methylmalonic acidemia (HP:0002912)	3.38446649
4	Thyroiditis (HP:0100646)	3.34212635
5	Severe combined immunodeficiency (HP:0004430)	3.32103524
6	Abnormality of the labia minora (HP:0012880)	3.29770381
7	Aplastic anemia (HP:0001915)	3.25270342
8	Mitochondrial inheritance (HP:0001427)	3.21628287
9	Hypoproteinemia (HP:0003075)	3.20013610
10	Acute necrotizing encephalopathy (HP:0006965)	3.06839834
11	Abnormality of midbrain morphology (HP:0002418)	3.05646348
12	Molar tooth sign on MRI (HP:0002419)	3.05646348
13	Hyperglycinemia (HP:0002154)	2.87382048
14	Abolished electroretinogram (ERG) (HP:0000550)	2.81152800
15	Abnormal mitochondria in muscle tissue (HP:0008316)	2.80176253
16	Methylmalonic aciduria (HP:0012120)	2.78282828
17	True hermaphroditism (HP:0010459)	2.78131353
18	Acute encephalopathy (HP:0006846)	2.76393298
19	Abnormality of cochlea (HP:0000375)	2.70972297
20	Combined immunodeficiency (HP:0005387)	2.66532281
21	Progressive macrocephaly (HP:0004481)	2.58233895
22	Eosinophilia (HP:0001880)	2.55700913
23	Increased CSF lactate (HP:0002490)	2.55095747
24	Abnormality of lateral ventricle (HP:0030047)	2.47103019
25	Carpal bone hypoplasia (HP:0001498)	2.46804560
26	Pancreatic fibrosis (HP:0100732)	2.46671920
27	Absent septum pellucidum (HP:0001331)	2.44656971
28	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.43754339
29	IgG deficiency (HP:0004315)	2.43472508
30	Nephronophthisis (HP:0000090)	2.43248067
31	Abnormality of eosinophils (HP:0001879)	2.40552334
32	Hepatocellular necrosis (HP:0001404)	2.40528251
33	3-Methylglutaconic aciduria (HP:0003535)	2.40400895
34	Increased hepatocellular lipid droplets (HP:0006565)	2.39598968
35	Morphological abnormality of the inner ear (HP:0011390)	2.38957412
36	Pancreatic cysts (HP:0001737)	2.38667604
37	Increased intramyocellular lipid droplets (HP:0012240)	2.34130607
38	Hyperglycinuria (HP:0003108)	2.34119840
39	Abnormality of glycine metabolism (HP:0010895)	2.33351409
40	Abnormality of serine family amino acid metabolism (HP:0010894)	2.33351409
41	Amyotrophic lateral sclerosis (HP:0007354)	2.32225513
42	Dyskinesia (HP:0100660)	2.31257622
43	Pendular nystagmus (HP:0012043)	2.29870379
44	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.29458807
45	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.29458807
46	Hepatic necrosis (HP:0002605)	2.27432307
47	Optic nerve hypoplasia (HP:0000609)	2.26276557
48	Chromsome breakage (HP:0040012)	2.25753441
49	Cerebral edema (HP:0002181)	2.23754626
50	Pancytopenia (HP:0001876)	2.18716659
51	Type 2 muscle fiber atrophy (HP:0003554)	2.18097268
52	Abnormality of T cell number (HP:0011839)	2.16038512
53	Hypoplasia of the thymus (HP:0000778)	2.15732432
54	Congenital stationary night blindness (HP:0007642)	2.14664781
55	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.11487081
56	Diastasis recti (HP:0001540)	2.10998842
57	Panhypogammaglobulinemia (HP:0003139)	2.09584484
58	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.09330014
59	Abnormality of macular pigmentation (HP:0008002)	2.09197039
60	Lipid accumulation in hepatocytes (HP:0006561)	2.09192991
61	T lymphocytopenia (HP:0005403)	2.08775620
62	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.08280882
63	Medial flaring of the eyebrow (HP:0010747)	2.06179476
64	Facial cleft (HP:0002006)	2.05537402
65	Hypomagnesemia (HP:0002917)	2.04318186
66	Short tibia (HP:0005736)	2.02852179
67	Poor speech (HP:0002465)	1.97411204
68	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.96726673
69	Meckel diverticulum (HP:0002245)	1.95344142
70	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.94050441
71	Abnormality of the septum pellucidum (HP:0007375)	1.91282041
72	Hypoplastic iliac wings (HP:0002866)	1.89379460
73	Septo-optic dysplasia (HP:0100842)	1.89329226
74	Delayed CNS myelination (HP:0002188)	1.87286487
75	Increased IgM level (HP:0003496)	1.87063254
76	Nephrogenic diabetes insipidus (HP:0009806)	1.85635881
77	Erythroderma (HP:0001019)	1.84434248
78	Renal Fanconi syndrome (HP:0001994)	1.84084545
79	Progressive inability to walk (HP:0002505)	1.83772126
80	Abnormal rod and cone electroretinograms (HP:0008323)	1.82964467
81	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.82491500
82	Increased serum lactate (HP:0002151)	1.81069375
83	Abnormality of the prostate (HP:0008775)	1.79629068
84	Abnormality of the ileum (HP:0001549)	1.79382033
85	Lethargy (HP:0001254)	1.78129847
86	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.77968934
87	Aplasia/hypoplasia of the uterus (HP:0008684)	1.77763374
88	Lactic acidosis (HP:0003128)	1.77705911
89	Chronic hepatic failure (HP:0100626)	1.77648370
90	Generalized aminoaciduria (HP:0002909)	1.77598982
91	Stenosis of the external auditory canal (HP:0000402)	1.77265574
92	Autoimmune hemolytic anemia (HP:0001890)	1.77205436
93	Congenital, generalized hypertrichosis (HP:0004540)	1.77115489
94	Congenital primary aphakia (HP:0007707)	1.77003551
95	Abnormality of the renal cortex (HP:0011035)	1.76082526
96	Aplasia/Hypoplasia of the patella (HP:0006498)	1.74983193
97	Decreased central vision (HP:0007663)	1.74316208
98	Amniotic constriction ring (HP:0009775)	1.74171801
99	Abnormality of placental membranes (HP:0011409)	1.74171801
100	Optic disc pallor (HP:0000543)	1.74117597

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK38L	4.03953026
2	CDC7	2.54449211
3	EIF2AK3	2.42560169
4	KDR	2.40758540
5	TXK	2.37040562
6	BRSK2	2.19753046
7	CASK	2.19574840
8	MAP4K2	2.12480252
9	FRK	2.12459534
10	EIF2AK1	2.11216633
11	TRIM28	2.04169729
12	PINK1	2.02241792
13	BUB1	1.99315647
14	BCKDK	1.97863522
15	GRK1	1.94691295
16	ZAK	1.86008501
17	BCR	1.79504055
18	ADRBK2	1.74765370
19	PLK2	1.71279090
20	WEE1	1.64311797
21	MAP3K12	1.63914398
22	TIE1	1.62545874
23	WNK3	1.61813767
24	BMPR1B	1.59382066
25	NEK1	1.53863438
26	VRK1	1.52031412
27	ERBB3	1.44911891
28	NUAK1	1.39221799
29	MAP3K4	1.37297260
30	MAPK13	1.35389265
31	CSNK1G1	1.32983058
32	MST4	1.31890306
33	CSNK1G3	1.27951453
34	CSNK1G2	1.26845727
35	VRK2	1.24034175
36	MAP2K7	1.23788747
37	DYRK2	1.23631954
38	STK39	1.18896098
39	CDK19	1.18873699
40	PLK3	1.15520618
41	OXSR1	1.12655415
42	PNCK	1.04424646
43	BRSK1	0.97898100
44	CSNK1A1L	0.95702456
45	PLK1	0.94867561
46	MKNK1	0.91801901
47	MKNK2	0.88470034
48	TNIK	0.88468885
49	BLK	0.88016471
50	TEC	0.81283876
51	SRPK1	0.81152210
52	PLK4	0.81024625
53	SIK3	0.78519316
54	MYLK	0.77555183
55	PRKCE	0.73865480
56	CCNB1	0.71017466
57	CAMKK2	0.69587893
58	PAK3	0.68224484
59	ACVR1B	0.68157214
60	TLK1	0.68095950
61	TTK	0.65518458
62	ITK	0.63888949
63	WNK1	0.63816596
64	PTK2B	0.61594857
65	STK16	0.60570298
66	INSRR	0.59349129
67	ATR	0.58312732
68	FLT3	0.55745485
69	PRKCQ	0.55215026
70	DAPK1	0.55065657
71	PRKCG	0.52087407
72	CHEK2	0.51269449
73	KIT	0.50626223
74	CSNK2A1	0.50543853
75	WNK4	0.49611577
76	CDK3	0.49554355
77	ATM	0.48553429
78	RPS6KA5	0.47461162
79	CSNK1D	0.47095686
80	TAF1	0.45123096
81	CSNK1A1	0.44983103
82	GRK7	0.44823442
83	CAMK2A	0.44375780
84	RPS6KA4	0.43989599
85	EPHA4	0.42832278
86	PRKACA	0.41733107
87	MINK1	0.41542296
88	OBSCN	0.39381790
89	AURKB	0.38700833
90	NME1	0.38588118
91	CSNK2A2	0.38093777
92	SYK	0.37296601
93	ROCK1	0.36357915
94	PKN1	0.35391713
95	STK38	0.35339490
96	ADRBK1	0.32021091
97	FES	0.31414994
98	EIF2AK2	0.30914891
99	PRKCA	0.30374494
100	GRK5	0.29537086

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.48685681
2	Protein export_Homo sapiens_hsa03060	3.37009711
3	DNA replication_Homo sapiens_hsa03030	3.24561864
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.80201083
5	Mismatch repair_Homo sapiens_hsa03430	2.62408040
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.58406781
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.41126510
8	Parkinsons disease_Homo sapiens_hsa05012	2.38974429
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.19067886
10	RNA polymerase_Homo sapiens_hsa03020	2.14964847
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10642842
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.07980703
13	Homologous recombination_Homo sapiens_hsa03440	2.01035921
14	Sulfur metabolism_Homo sapiens_hsa00920	1.98744324
15	Propanoate metabolism_Homo sapiens_hsa00640	1.90993646
16	Phototransduction_Homo sapiens_hsa04744	1.89816726
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.89669057
18	Basal transcription factors_Homo sapiens_hsa03022	1.89355710
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.82725483
20	RNA degradation_Homo sapiens_hsa03018	1.62708212
21	Huntingtons disease_Homo sapiens_hsa05016	1.57731619
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.55859876
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.53780391
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.52338935
25	Alzheimers disease_Homo sapiens_hsa05010	1.35476315
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.33499451
27	Butanoate metabolism_Homo sapiens_hsa00650	1.31075010
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.27401399
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.26506697
30	Spliceosome_Homo sapiens_hsa03040	1.24392777
31	Base excision repair_Homo sapiens_hsa03410	1.24192901
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.22414578
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.16856845
34	RNA transport_Homo sapiens_hsa03013	1.10982971
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.10025906
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.06922480
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.06619078
38	Peroxisome_Homo sapiens_hsa04146	1.06240647
39	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.04475714
40	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.03245307
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.00712685
42	Purine metabolism_Homo sapiens_hsa00230	0.99433018
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.99048511
44	Retinol metabolism_Homo sapiens_hsa00830	0.98625805
45	Regulation of autophagy_Homo sapiens_hsa04140	0.95892321
46	Cardiac muscle contraction_Homo sapiens_hsa04260	0.95375676
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.94992499
48	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.92123960
49	Type I diabetes mellitus_Homo sapiens_hsa04940	0.90760942
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88158075
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88021347
52	Pyruvate metabolism_Homo sapiens_hsa00620	0.87503619
53	Allograft rejection_Homo sapiens_hsa05330	0.86796367
54	Cell cycle_Homo sapiens_hsa04110	0.83390210
55	Linoleic acid metabolism_Homo sapiens_hsa00591	0.82229361
56	Graft-versus-host disease_Homo sapiens_hsa05332	0.81272266
57	Rheumatoid arthritis_Homo sapiens_hsa05323	0.80700733
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.80309777
59	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.80005104
60	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.77429731
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.77301365
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.73773034
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70429939
64	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.69022061
65	Taste transduction_Homo sapiens_hsa04742	0.67108249
66	Antigen processing and presentation_Homo sapiens_hsa04612	0.65842476
67	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.65486874
68	Metabolic pathways_Homo sapiens_hsa01100	0.65202636
69	One carbon pool by folate_Homo sapiens_hsa00670	0.64888673
70	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63512606
71	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.63276630
72	Fatty acid elongation_Homo sapiens_hsa00062	0.62565232
73	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.61470064
74	Asthma_Homo sapiens_hsa05310	0.61287562
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.60028896
76	Circadian rhythm_Homo sapiens_hsa04710	0.59823571
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56825636
78	Oocyte meiosis_Homo sapiens_hsa04114	0.54666306
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.53599245
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50294499
81	mRNA surveillance pathway_Homo sapiens_hsa03015	0.50221023
82	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.50088857
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48608863
84	Sulfur relay system_Homo sapiens_hsa04122	0.46390066
85	Olfactory transduction_Homo sapiens_hsa04740	0.46251387
86	Ribosome_Homo sapiens_hsa03010	0.45821458
87	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45152893
88	Caffeine metabolism_Homo sapiens_hsa00232	0.44842449
89	p53 signaling pathway_Homo sapiens_hsa04115	0.42362303
90	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.42084099
91	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.39931130
92	Nicotine addiction_Homo sapiens_hsa05033	0.39322389
93	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38643027
94	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.36833883
95	Ether lipid metabolism_Homo sapiens_hsa00565	0.36186609
96	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34175028
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.33949166
98	Folate biosynthesis_Homo sapiens_hsa00790	0.29879547
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28012993
100	Shigellosis_Homo sapiens_hsa05131	0.27284655

MORF4L1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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