ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.86638419
2	gamma-aminobutyric acid transport (GO:0015812)	5.45685415
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.19465264
4	ATP synthesis coupled proton transport (GO:0015986)	5.19465264
5	olfactory bulb development (GO:0021772)	5.09352653
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.03113684
7	protein prenylation (GO:0018342)	4.88937098
8	prenylation (GO:0097354)	4.88937098
9	dendritic spine morphogenesis (GO:0060997)	4.88045589
10	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.85020154
11	regulation of translation, ncRNA-mediated (GO:0045974)	4.85020154
12	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.85020154
13	acrosome assembly (GO:0001675)	4.83768575
14	leukotriene biosynthetic process (GO:0019370)	4.80980617
15	fatty acid elongation (GO:0030497)	4.48862578
16	retinal ganglion cell axon guidance (GO:0031290)	4.46979562
17	protein polyglutamylation (GO:0018095)	4.37440953
18	epithelial cilium movement (GO:0003351)	4.26713444
19	ephrin receptor signaling pathway (GO:0048013)	4.25578513
20	positive regulation of RNA splicing (GO:0033120)	4.23476306
21	intraciliary transport (GO:0042073)	4.20795737
22	respiratory chain complex IV assembly (GO:0008535)	4.19861947
23	single strand break repair (GO:0000012)	4.17695745
24	protein localization to cilium (GO:0061512)	4.06846196
25	cilium or flagellum-dependent cell motility (GO:0001539)	4.04990288
26	regulation of gene silencing by RNA (GO:0060966)	3.86560302
27	regulation of posttranscriptional gene silencing (GO:0060147)	3.86560302
28	regulation of gene silencing by miRNA (GO:0060964)	3.86560302
29	ribosomal small subunit assembly (GO:0000028)	3.75093757
30	DNA ligation (GO:0006266)	3.74834448
31	artery development (GO:0060840)	3.55422097
32	cytochrome complex assembly (GO:0017004)	3.54007051
33	negative regulation of Ras GTPase activity (GO:0034261)	3.51434643
34	nucleobase catabolic process (GO:0046113)	3.51393119
35	protein K11-linked ubiquitination (GO:0070979)	3.49327829
36	transmission of nerve impulse (GO:0019226)	3.45975807
37	resolution of meiotic recombination intermediates (GO:0000712)	3.42908026
38	ovulation cycle (GO:0042698)	3.38723284
39	regulation of cilium movement (GO:0003352)	3.33630050
40	kinetochore assembly (GO:0051382)	3.31884589
41	chaperone-mediated protein transport (GO:0072321)	3.31795023
42	mitochondrial fission (GO:0000266)	3.29323581
43	DNA topological change (GO:0006265)	3.28058852
44	response to pheromone (GO:0019236)	3.23341377
45	pyrimidine nucleobase catabolic process (GO:0006208)	3.22145189
46	protein K6-linked ubiquitination (GO:0085020)	3.21556566
47	protein complex biogenesis (GO:0070271)	3.16433852
48	neuroblast proliferation (GO:0007405)	3.10778440
49	positive regulation of mRNA processing (GO:0050685)	3.09772096
50	spliceosomal complex assembly (GO:0000245)	3.07265008
51	spermatid nucleus differentiation (GO:0007289)	3.03872608
52	presynaptic membrane assembly (GO:0097105)	3.03445385
53	cilium assembly (GO:0042384)	3.01556753
54	cilium organization (GO:0044782)	3.01341466
55	regulation of centriole replication (GO:0046599)	2.98467236
56	cilium movement (GO:0003341)	2.96971402
57	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.95152364
58	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.94675761
59	presynaptic membrane organization (GO:0097090)	2.94598773
60	mitochondrial DNA replication (GO:0006264)	2.93925393
61	cilium morphogenesis (GO:0060271)	2.93406031
62	positive regulation of mitochondrial fission (GO:0090141)	2.92587105
63	regulation of somitogenesis (GO:0014807)	2.91556252
64	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.90482839
65	positive regulation of myoblast differentiation (GO:0045663)	2.89470752
66	sequestering of actin monomers (GO:0042989)	2.88889416
67	cranial nerve morphogenesis (GO:0021602)	2.87277978
68	non-recombinational repair (GO:0000726)	2.85807664
69	double-strand break repair via nonhomologous end joining (GO:0006303)	2.85807664
70	leukotriene metabolic process (GO:0006691)	2.84630259
71	establishment of integrated proviral latency (GO:0075713)	2.82593113
72	inner mitochondrial membrane organization (GO:0007007)	2.80378600
73	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.80277080
74	ATP biosynthetic process (GO:0006754)	2.78233969
75	tachykinin receptor signaling pathway (GO:0007217)	2.77988507
76	kinetochore organization (GO:0051383)	2.77602784
77	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.77592377
78	NADH dehydrogenase complex assembly (GO:0010257)	2.77592377
79	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.77592377
80	mitochondrial respiratory chain complex assembly (GO:0033108)	2.77471710
81	establishment of nucleus localization (GO:0040023)	2.71396843
82	bone remodeling (GO:0046849)	2.69421120
83	icosanoid biosynthetic process (GO:0046456)	2.68694071
84	fatty acid derivative biosynthetic process (GO:1901570)	2.68694071
85	nucleotide transmembrane transport (GO:1901679)	2.64936170
86	histone deubiquitination (GO:0016578)	2.63425560
87	microtubule depolymerization (GO:0007019)	2.60802250
88	tyrosine phosphorylation of STAT protein (GO:0007260)	2.59610120
89	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.58507537
90	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.56744549
91	negative regulation of mast cell activation (GO:0033004)	2.55817471
92	spinal cord motor neuron differentiation (GO:0021522)	2.54212774
93	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.54043711
94	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.54043711
95	negative regulation of gene silencing (GO:0060969)	2.53684341
96	glycosphingolipid biosynthetic process (GO:0006688)	2.53525311
97	regulation of mRNA 3-end processing (GO:0031440)	2.52660701
98	positive regulation of mRNA metabolic process (GO:1903313)	2.52623620
99	neural tube formation (GO:0001841)	2.50652126
100	neural precursor cell proliferation (GO:0061351)	2.49665959

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	5.32127522
2	IGF1R_20145208_ChIP-Seq_DFB_Human	5.15616168
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.54435484
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.34493048
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.77219544
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.67367255
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.64388707
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.56923026
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.53604157
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.51043916
11	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.50439747
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.41927117
13	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.38057116
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.34155291
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.21270269
16	GBX2_23144817_ChIP-Seq_PC3_Human	2.18327353
17	FUS_26573619_Chip-Seq_HEK293_Human	2.12949579
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.12788598
19	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.12606141
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.12030302
21	EWS_26573619_Chip-Seq_HEK293_Human	2.03830332
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.98385234
23	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.97641492
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.96093472
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.92138602
26	P300_19829295_ChIP-Seq_ESCs_Human	1.91716489
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.90671124
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.82945440
29	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.74178368
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.71023163
31	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.68199808
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60092385
33	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.59516397
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.57967759
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55919907
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.45311708
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44786088
38	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.42148719
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.41863312
40	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.39462443
41	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39462443
42	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.39380946
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.37109682
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37109682
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.36557808
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34138095
47	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.33109426
48	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.32966457
49	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.32665935
50	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32269305
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29939632
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29551390
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26994175
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.26468152
55	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.26176500
56	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26077281
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.24106407
58	ELK1_19687146_ChIP-ChIP_HELA_Human	1.24047295
59	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21054805
60	SMAD4_21799915_ChIP-Seq_A2780_Human	1.20572373
61	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19421513
62	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18652205
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18202990
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18051873
65	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.17183534
66	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16110679
67	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13497992
68	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.11975919
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11965163
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11965163
71	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.10795353
72	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.10703808
73	VDR_23849224_ChIP-Seq_CD4+_Human	1.10420501
74	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.10077978
75	TCF4_23295773_ChIP-Seq_U87_Human	1.09525359
76	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.09288807
77	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.09031513
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08677864
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08486856
80	ER_23166858_ChIP-Seq_MCF-7_Human	1.07250358
81	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.06547744
82	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.06235443
83	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.04188215
84	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.03461611
85	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.02330415
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01176425
87	STAT3_23295773_ChIP-Seq_U87_Human	1.00773540
88	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.00422036
89	RXR_22108803_ChIP-Seq_LS180_Human	0.99907273
90	AR_21572438_ChIP-Seq_LNCaP_Human	0.98889305
91	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98576537
92	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97725856
93	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97563659
94	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.97266688
95	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.96955899
96	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.96757335
97	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.96676387
98	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.95071485
99	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.94385922
100	AR_25329375_ChIP-Seq_VCAP_Human	0.93409233

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.71923262
2	MP0002938_white_spotting	3.41278129
3	MP0005645_abnormal_hypothalamus_physiol	3.11948283
4	MP0000427_abnormal_hair_cycle	3.08893014
5	MP0001529_abnormal_vocalization	2.95734578
6	MP0005171_absent_coat_pigmentation	2.87914269
7	MP0003646_muscle_fatigue	2.81827604
8	MP0002736_abnormal_nociception_after	2.78457847
9	MP0008789_abnormal_olfactory_epithelium	2.60964002
10	MP0005084_abnormal_gallbladder_morpholo	2.48252582
11	MP0001968_abnormal_touch/_nociception	2.37942279
12	MP0008995_early_reproductive_senescence	2.33655383
13	MP0002090_abnormal_vision	2.30527504
14	MP0000569_abnormal_digit_pigmentation	2.23944595
15	MP0006292_abnormal_olfactory_placode	2.22807808
16	MP0003195_calcinosis	2.20804014
17	MP0005499_abnormal_olfactory_system	2.16154253
18	MP0005394_taste/olfaction_phenotype	2.16154253
19	MP0005083_abnormal_biliary_tract	2.08213796
20	MP0003786_premature_aging	2.00869270
21	MP0005377_hearing/vestibular/ear_phenot	2.00601071
22	MP0003878_abnormal_ear_physiology	2.00601071
23	MP0001293_anophthalmia	1.94788603
24	MP0004133_heterotaxia	1.90013719
25	MP0005187_abnormal_penis_morphology	1.86903534
26	MP0005248_abnormal_Harderian_gland	1.81540150
27	MP0000372_irregular_coat_pigmentation	1.79759479
28	MP0000647_abnormal_sebaceous_gland	1.76209369
29	MP0009379_abnormal_foot_pigmentation	1.75939908
30	MP0000778_abnormal_nervous_system	1.74166088
31	MP0005551_abnormal_eye_electrophysiolog	1.73351532
32	MP0000631_abnormal_neuroendocrine_gland	1.72741932
33	MP0006072_abnormal_retinal_apoptosis	1.66834486
34	MP0005174_abnormal_tail_pigmentation	1.66361907
35	MP0002254_reproductive_system_inflammat	1.51227410
36	MP0010094_abnormal_chromosome_stability	1.51218317
37	MP0001485_abnormal_pinna_reflex	1.50580830
38	MP0002233_abnormal_nose_morphology	1.50199021
39	MP0003880_abnormal_central_pattern	1.38022183
40	MP0002102_abnormal_ear_morphology	1.28917388
41	MP0002095_abnormal_skin_pigmentation	1.26053113
42	MP0002184_abnormal_innervation	1.23587627
43	MP0001486_abnormal_startle_reflex	1.21799240
44	MP0002697_abnormal_eye_size	1.21433528
45	MP0005195_abnormal_posterior_eye	1.19862217
46	MP0005253_abnormal_eye_physiology	1.18465210
47	MP0002735_abnormal_chemical_nociception	1.18053462
48	MP0008057_abnormal_DNA_replication	1.16401352
49	MP0006035_abnormal_mitochondrial_morpho	1.15787566
50	MP0001346_abnormal_lacrimal_gland	1.13854384
51	MP0005408_hypopigmentation	1.13095672
52	MP0004043_abnormal_pH_regulation	1.11897704
53	MP0006276_abnormal_autonomic_nervous	1.09656607
54	MP0000566_synostosis	1.07911607
55	MP0003122_maternal_imprinting	1.06417172
56	MP0002751_abnormal_autonomic_nervous	1.06128902
57	MP0009697_abnormal_copulation	1.05567047
58	MP0003221_abnormal_cardiomyocyte_apopto	1.04895971
59	MP0005391_vision/eye_phenotype	1.03984267
60	MP0003121_genomic_imprinting	1.03747082
61	MP0003315_abnormal_perineum_morphology	1.03662412
62	MP0002098_abnormal_vibrissa_morphology	1.03332023
63	MP0005423_abnormal_somatic_nervous	0.98580322
64	MP0005647_abnormal_sex_gland	0.97715325
65	MP0002638_abnormal_pupillary_reflex	0.97452750
66	MP0005075_abnormal_melanosome_morpholog	0.94025536
67	MP0004215_abnormal_myocardial_fiber	0.93505334
68	MP0002163_abnormal_gland_morphology	0.93090559
69	MP0001929_abnormal_gametogenesis	0.92042917
70	MP0001984_abnormal_olfaction	0.90932105
71	MP0002127_abnormal_cardiovascular_syste	0.89837257
72	MP0003186_abnormal_redox_activity	0.87140836
73	MP0003183_abnormal_peptide_metabolism	0.86621482
74	MP0004924_abnormal_behavior	0.84512328
75	MP0005386_behavior/neurological_phenoty	0.84512328
76	MP0003698_abnormal_male_reproductive	0.83628572
77	MP0001286_abnormal_eye_development	0.83469238
78	MP0003111_abnormal_nucleus_morphology	0.83094049
79	MP0002822_catalepsy	0.83081716
80	MP0005389_reproductive_system_phenotype	0.82585768
81	MP0002752_abnormal_somatic_nervous	0.82199657
82	MP0003937_abnormal_limbs/digits/tail_de	0.82017308
83	MP0008058_abnormal_DNA_repair	0.81464536
84	MP0004484_altered_response_of	0.80392894
85	MP0003861_abnormal_nervous_system	0.77039791
86	MP0002067_abnormal_sensory_capabilities	0.76260238
87	MP0002092_abnormal_eye_morphology	0.75583825
88	MP0002882_abnormal_neuron_morphology	0.73732848
89	MP0002557_abnormal_social/conspecific_i	0.72834944
90	MP0003077_abnormal_cell_cycle	0.72575926
91	MP0002109_abnormal_limb_morphology	0.71527300
92	MP0001764_abnormal_homeostasis	0.70365983
93	MP0005085_abnormal_gallbladder_physiolo	0.70024849
94	MP0004381_abnormal_hair_follicle	0.69886443
95	MP0000653_abnormal_sex_gland	0.69742541
96	MP0002160_abnormal_reproductive_system	0.69700331
97	MP0000026_abnormal_inner_ear	0.68848297
98	MP0000613_abnormal_salivary_gland	0.68433881
99	MP0004142_abnormal_muscle_tone	0.67134702
100	MP0001986_abnormal_taste_sensitivity	0.66793602

Predicted human phenotypes

Rank	Gene Set	Z-score
1	High anterior hairline (HP:0009890)	4.07523321
2	Neonatal respiratory distress (HP:0002643)	4.03645843
3	Short tibia (HP:0005736)	3.98244201
4	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.97504939
5	Genetic anticipation (HP:0003743)	3.81685545
6	Anhidrosis (HP:0000970)	3.52873818
7	Pancreatic fibrosis (HP:0100732)	3.49566848
8	Broad alveolar ridges (HP:0000187)	3.34930843
9	Delayed epiphyseal ossification (HP:0002663)	3.23166955
10	Hypophosphatemic rickets (HP:0004912)	3.19306166
11	Tubular atrophy (HP:0000092)	3.08647613
12	Supernumerary spleens (HP:0009799)	3.01204162
13	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.90515975
14	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.90515975
15	Hyperventilation (HP:0002883)	2.82328067
16	Fibular aplasia (HP:0002990)	2.71724432
17	Proximal placement of thumb (HP:0009623)	2.70965882
18	Hypotrichosis (HP:0001006)	2.70570885
19	Thyroiditis (HP:0100646)	2.69539467
20	Abnormality of chromosome stability (HP:0003220)	2.60685174
21	Progressive cerebellar ataxia (HP:0002073)	2.60317823
22	Increased hepatocellular lipid droplets (HP:0006565)	2.58351958
23	Premature skin wrinkling (HP:0100678)	2.56937754
24	Proximal tubulopathy (HP:0000114)	2.56477755
25	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.52368399
26	Postaxial foot polydactyly (HP:0001830)	2.51307003
27	Severe combined immunodeficiency (HP:0004430)	2.50683132
28	Abnormality of abdominal situs (HP:0011620)	2.49452817
29	Abdominal situs inversus (HP:0003363)	2.49452817
30	Absent radius (HP:0003974)	2.49156838
31	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.48428664
32	Congenital sensorineural hearing impairment (HP:0008527)	2.47844363
33	Abnormality of the labia minora (HP:0012880)	2.47520022
34	Tubulointerstitial fibrosis (HP:0005576)	2.47102472
35	Deviation of the thumb (HP:0009603)	2.45455921
36	Aplasia involving forearm bones (HP:0009822)	2.45114242
37	Absent forearm bone (HP:0003953)	2.45114242
38	Pancreatic cysts (HP:0001737)	2.44849834
39	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.44299198
40	Lipid accumulation in hepatocytes (HP:0006561)	2.44257982
41	Gastrointestinal atresia (HP:0002589)	2.44123350
42	Short humerus (HP:0005792)	2.43407269
43	Facial hemangioma (HP:0000329)	2.43313158
44	Heterochromia iridis (HP:0001100)	2.43018224
45	Genital tract atresia (HP:0001827)	2.42219837
46	True hermaphroditism (HP:0010459)	2.41693451
47	Nephronophthisis (HP:0000090)	2.41671783
48	Asplenia (HP:0001746)	2.41583420
49	Aplasia/hypoplasia of the humerus (HP:0006507)	2.41154668
50	Medial flaring of the eyebrow (HP:0010747)	2.35300183
51	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.33053988
52	Hepatocellular necrosis (HP:0001404)	2.22702908
53	Osteomalacia (HP:0002749)	2.21699684
54	Upper limb muscle weakness (HP:0003484)	2.20371048
55	Glycosuria (HP:0003076)	2.17232033
56	Abnormality of urine glucose concentration (HP:0011016)	2.17232033
57	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.16961609
58	Microglossia (HP:0000171)	2.15958224
59	Urinary urgency (HP:0000012)	2.15557263
60	2-3 toe syndactyly (HP:0004691)	2.13333895
61	Metaphyseal dysplasia (HP:0100255)	2.13108115
62	Tubulointerstitial abnormality (HP:0001969)	2.10092803
63	Cutaneous finger syndactyly (HP:0010554)	2.08854144
64	Periodontitis (HP:0000704)	2.08832481
65	Carpal bone hypoplasia (HP:0001498)	2.08730928
66	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.08503545
67	Congenital primary aphakia (HP:0007707)	2.06393426
68	Malignant hyperthermia (HP:0002047)	2.06318852
69	Dyskinesia (HP:0100660)	2.06062717
70	Gait imbalance (HP:0002141)	2.04190495
71	Pachygyria (HP:0001302)	2.04008573
72	11 pairs of ribs (HP:0000878)	2.03810917
73	Hyperphosphaturia (HP:0003109)	2.01508361
74	Delayed myelination (HP:0012448)	2.01307308
75	Smooth philtrum (HP:0000319)	2.01070550
76	Abnormality of midbrain morphology (HP:0002418)	2.00154063
77	Molar tooth sign on MRI (HP:0002419)	2.00154063
78	Severe Myopia (HP:0011003)	1.99507275
79	Slow-growing hair (HP:0002217)	1.99010028
80	Abnormality of hair growth rate (HP:0011363)	1.99010028
81	Drooling (HP:0002307)	1.98986400
82	Abnormality of the 2nd finger (HP:0004100)	1.98539504
83	Dyschromatopsia (HP:0007641)	1.98512468
84	Renal Fanconi syndrome (HP:0001994)	1.97730584
85	Sloping forehead (HP:0000340)	1.96160086
86	Enlarged epiphyses (HP:0010580)	1.94940890
87	Ectopic kidney (HP:0000086)	1.94636210
88	Intestinal atresia (HP:0011100)	1.92585145
89	Gonadotropin excess (HP:0000837)	1.88708879
90	Abnormality of the lower motor neuron (HP:0002366)	1.87871785
91	Abnormality of the fibula (HP:0002991)	1.87858667
92	Congenital, generalized hypertrichosis (HP:0004540)	1.87034735
93	Abnormality of cochlea (HP:0000375)	1.85279991
94	Abnormality of the renal medulla (HP:0100957)	1.85069900
95	Aplasia of the musculature (HP:0100854)	1.83375633
96	Vaginal atresia (HP:0000148)	1.81473499
97	Esophageal atresia (HP:0002032)	1.81043849
98	Hepatic necrosis (HP:0002605)	1.80325264
99	Excessive salivation (HP:0003781)	1.80178404
100	Triphalangeal thumb (HP:0001199)	1.80102158

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	5.08299504
2	MAP3K6	4.52399948
3	MKNK2	3.65435488
4	TNIK	3.33716325
5	MAP4K2	3.10094119
6	MKNK1	2.83827384
7	PINK1	2.60219882
8	EPHB1	2.45768469
9	INSRR	2.43641020
10	PLK4	2.33445169
11	NUAK1	2.20898256
12	BRD4	2.16020203
13	BCR	2.12935035
14	STK38L	2.12168862
15	MAP3K4	2.08715997
16	UHMK1	1.94558802
17	NEK2	1.79202296
18	MAP2K7	1.78448513
19	FRK	1.54655217
20	MAP2K4	1.45811955
21	CASK	1.45738115
22	CDC7	1.44100066
23	TRIM28	1.41289658
24	YES1	1.33765832
25	NEK9	1.27205685
26	PLK2	1.26745848
27	MAPK13	1.25246684
28	GRK1	1.17005481
29	FER	1.16522426
30	NTRK2	1.13086187
31	STK39	1.10971289
32	SIK2	1.10868193
33	DYRK1A	1.08507483
34	ZAK	1.04944813
35	WNK1	0.96011140
36	FGR	0.94249448
37	BCKDK	0.93120914
38	DYRK3	0.91249508
39	IRAK1	0.89005784
40	SRPK1	0.88533558
41	BUB1	0.87770924
42	EIF2AK3	0.85881696
43	SIK3	0.84882640
44	CCNB1	0.84292715
45	PLK3	0.83705377
46	PAK3	0.82165727
47	EPHB2	0.77927507
48	PTK2B	0.76990929
49	BLK	0.76362259
50	ADRBK2	0.72162228
51	MATK	0.71714798
52	ERBB3	0.71319190
53	RPS6KA4	0.71071484
54	WNK4	0.69856469
55	PLK1	0.69708894
56	PIK3CA	0.69632014
57	BMPR1B	0.66370836
58	DYRK2	0.63786765
59	FGFR2	0.63493615
60	PRKD3	0.62454669
61	MAP3K5	0.62140467
62	STK3	0.60654457
63	STK38	0.57099624
64	MARK1	0.52750091
65	EPHA4	0.51527282
66	PKN1	0.47370464
67	OBSCN	0.47171406
68	PASK	0.46694496
69	BRSK2	0.46203543
70	OXSR1	0.46142792
71	ATR	0.45963988
72	ROCK1	0.45820820
73	ERBB2	0.45744971
74	PRKCG	0.43621415
75	MINK1	0.43133866
76	CSNK1G2	0.41607717
77	GRK5	0.40944152
78	VRK1	0.40398748
79	ADRBK1	0.40392931
80	CHEK2	0.40248181
81	TSSK6	0.39894062
82	PHKG1	0.38983796
83	PHKG2	0.38983796
84	TGFBR1	0.37747049
85	DYRK1B	0.36489178
86	RPS6KB1	0.35938615
87	MAP3K12	0.35239579
88	CSNK1A1	0.34860477
89	PRKCB	0.34327119
90	PRKCE	0.33857363
91	CDK6	0.30386054
92	CAMK1	0.28471232
93	AURKB	0.28428781
94	CDK8	0.28004010
95	ATM	0.26853634
96	FGFR1	0.26741414
97	NME1	0.25185101
98	CDK1	0.25024029
99	PRKAA1	0.23583945
100	ROCK2	0.23546985

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	4.33277515
2	Protein export_Homo sapiens_hsa03060	3.35700227
3	Homologous recombination_Homo sapiens_hsa03440	3.06795847
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.03090343
5	Parkinsons disease_Homo sapiens_hsa05012	2.68370708
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.57109561
7	Ribosome_Homo sapiens_hsa03010	2.56786535
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.42188988
9	Nicotine addiction_Homo sapiens_hsa05033	2.12099098
10	Steroid biosynthesis_Homo sapiens_hsa00100	2.01044474
11	Huntingtons disease_Homo sapiens_hsa05016	1.94281491
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.92951585
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.87449484
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.77021541
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.71673406
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.69742058
17	DNA replication_Homo sapiens_hsa03030	1.68704263
18	RNA transport_Homo sapiens_hsa03013	1.68465297
19	RNA degradation_Homo sapiens_hsa03018	1.67646463
20	Propanoate metabolism_Homo sapiens_hsa00640	1.66279085
21	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.66121273
22	Phototransduction_Homo sapiens_hsa04744	1.62955502
23	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.56601555
24	Alzheimers disease_Homo sapiens_hsa05010	1.56486355
25	Basal transcription factors_Homo sapiens_hsa03022	1.54986202
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.54669793
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.54523391
28	Mismatch repair_Homo sapiens_hsa03430	1.53538279
29	Spliceosome_Homo sapiens_hsa03040	1.53488890
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.47870455
31	Taste transduction_Homo sapiens_hsa04742	1.44481908
32	GABAergic synapse_Homo sapiens_hsa04727	1.39940404
33	Basal cell carcinoma_Homo sapiens_hsa05217	1.37893474
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.32623232
35	RNA polymerase_Homo sapiens_hsa03020	1.32039075
36	Butanoate metabolism_Homo sapiens_hsa00650	1.30241867
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.25756370
38	One carbon pool by folate_Homo sapiens_hsa00670	1.14576538
39	Linoleic acid metabolism_Homo sapiens_hsa00591	1.12412732
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.12011243
41	Fatty acid elongation_Homo sapiens_hsa00062	1.10854049
42	Axon guidance_Homo sapiens_hsa04360	1.08477997
43	Cocaine addiction_Homo sapiens_hsa05030	1.08263956
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.07640023
45	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.05511278
46	Ether lipid metabolism_Homo sapiens_hsa00565	1.03863385
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03202252
48	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.01462506
49	Cell cycle_Homo sapiens_hsa04110	1.00290902
50	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.96582082
51	Base excision repair_Homo sapiens_hsa03410	0.96058203
52	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.93889389
53	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.89396382
54	Serotonergic synapse_Homo sapiens_hsa04726	0.84669101
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.83904031
56	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.82035592
57	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.81308318
58	Glutathione metabolism_Homo sapiens_hsa00480	0.81165985
59	Melanogenesis_Homo sapiens_hsa04916	0.78709153
60	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.78522545
61	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.75772899
62	Pyrimidine metabolism_Homo sapiens_hsa00240	0.74133929
63	Proteasome_Homo sapiens_hsa03050	0.73425938
64	Morphine addiction_Homo sapiens_hsa05032	0.73076515
65	Olfactory transduction_Homo sapiens_hsa04740	0.68648199
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68576269
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67842652
68	p53 signaling pathway_Homo sapiens_hsa04115	0.63285754
69	Purine metabolism_Homo sapiens_hsa00230	0.63086932
70	Glutamatergic synapse_Homo sapiens_hsa04724	0.61430423
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58313730
72	Retinol metabolism_Homo sapiens_hsa00830	0.58208885
73	Oocyte meiosis_Homo sapiens_hsa04114	0.57836721
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57032274
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56380728
76	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53868285
77	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.49431941
78	Amphetamine addiction_Homo sapiens_hsa05031	0.49272382
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.47148756
80	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46864946
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45751957
82	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.43879782
83	Circadian entrainment_Homo sapiens_hsa04713	0.42798110
84	Metabolic pathways_Homo sapiens_hsa01100	0.42118839
85	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.41677712
86	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.39903373
87	Tryptophan metabolism_Homo sapiens_hsa00380	0.37245415
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.36906850
89	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.36640117
90	Wnt signaling pathway_Homo sapiens_hsa04310	0.36633795
91	Pyruvate metabolism_Homo sapiens_hsa00620	0.35305837
92	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.35251001
93	Alcoholism_Homo sapiens_hsa05034	0.34213025
94	Tight junction_Homo sapiens_hsa04530	0.30242059
95	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.27825051
96	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.26436275
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.24828987
98	Caffeine metabolism_Homo sapiens_hsa00232	0.24503105
99	Hippo signaling pathway_Homo sapiens_hsa04390	0.23928987
100	Cholinergic synapse_Homo sapiens_hsa04725	0.22971611

MORF4L1P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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