ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of relaxation of muscle (GO:1901077)	7.50249726
2	negative regulation of sodium ion transport (GO:0010766)	7.47824691
3	response to pheromone (GO:0019236)	7.15587429
4	regulation of cell communication by electrical coupling (GO:0010649)	6.63539414
5	relaxation of cardiac muscle (GO:0055119)	6.41704785
6	branching involved in prostate gland morphogenesis (GO:0060442)	6.05072619
7	regulation of action potential (GO:0098900)	5.66470211
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.04027315
9	NADH dehydrogenase complex assembly (GO:0010257)	5.04027315
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.04027315
11	regulation of mesenchymal cell apoptotic process (GO:2001053)	4.75950629
12	ATP synthesis coupled proton transport (GO:0015986)	4.66392609
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.66392609
14	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.55839469
15	chaperone-mediated protein transport (GO:0072321)	4.48268037
16	proteasome assembly (GO:0043248)	4.43776527
17	protein complex biogenesis (GO:0070271)	4.41866777
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.39747583
19	relaxation of muscle (GO:0090075)	4.38512851
20	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	4.36478981
21	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	4.36478981
22	positive regulation of cardiac muscle hypertrophy (GO:0010613)	4.35873022
23	positive regulation of muscle hypertrophy (GO:0014742)	4.35873022
24	positive regulation of megakaryocyte differentiation (GO:0045654)	4.05529363
25	mitochondrial respiratory chain complex assembly (GO:0033108)	4.05057715
26	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.96541110
27	anatomical structure regression (GO:0060033)	3.89352313
28	GTP biosynthetic process (GO:0006183)	3.84011534
29	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.83614503
30	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.76577576
31	platelet dense granule organization (GO:0060155)	3.74990333
32	water-soluble vitamin biosynthetic process (GO:0042364)	3.73878158
33	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.72886354
34	rRNA catabolic process (GO:0016075)	3.71167540
35	UTP metabolic process (GO:0046051)	3.68166697
36	L-methionine salvage (GO:0071267)	3.67088224
37	L-methionine biosynthetic process (GO:0071265)	3.67088224
38	amino acid salvage (GO:0043102)	3.67088224
39	hindbrain development (GO:0030902)	3.63290108
40	translational termination (GO:0006415)	3.62623899
41	DNA deamination (GO:0045006)	3.60551730
42	viral transcription (GO:0019083)	3.58744164
43	male genitalia development (GO:0030539)	3.58209743
44	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.54774688
45	regulation of heart rate by cardiac conduction (GO:0086091)	3.53076835
46	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.52864516
47	pseudouridine synthesis (GO:0001522)	3.52321972
48	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.52207535
49	deoxyribose phosphate biosynthetic process (GO:0046385)	3.52207535
50	ventricular septum development (GO:0003281)	3.45940427
51	ribosomal small subunit biogenesis (GO:0042274)	3.45777168
52	GPI anchor metabolic process (GO:0006505)	3.44084780
53	respiratory chain complex IV assembly (GO:0008535)	3.39403483
54	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.33194014
55	ribosomal small subunit assembly (GO:0000028)	3.32718998
56	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.31348957
57	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.31240167
58	pyrimidine nucleotide catabolic process (GO:0006244)	3.30552158
59	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.29353186
60	inner mitochondrial membrane organization (GO:0007007)	3.27629773
61	UTP biosynthetic process (GO:0006228)	3.27121574
62	kinetochore assembly (GO:0051382)	3.27034449
63	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	3.26727367
64	endothelial cell morphogenesis (GO:0001886)	3.21498297
65	ATP biosynthetic process (GO:0006754)	3.14575525
66	reproductive system development (GO:0061458)	3.14341503
67	myoblast migration (GO:0051451)	3.13569304
68	prostate gland epithelium morphogenesis (GO:0060740)	3.13560658
69	deoxyribonucleotide catabolic process (GO:0009264)	3.11895177
70	guanosine-containing compound biosynthetic process (GO:1901070)	3.11856424
71	regulation of histone deacetylation (GO:0031063)	3.10745791
72	oxidative demethylation (GO:0070989)	3.10213985
73	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.09696124
74	deoxyribose phosphate catabolic process (GO:0046386)	3.08933181
75	protein targeting to mitochondrion (GO:0006626)	3.07418907
76	base-excision repair, AP site formation (GO:0006285)	3.07173889
77	protein targeting to ER (GO:0045047)	3.06701590
78	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.02325522
79	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.01488871
80	cotranslational protein targeting to membrane (GO:0006613)	3.00495646
81	negative regulation of fibroblast apoptotic process (GO:2000270)	3.00293869
82	translation (GO:0006412)	2.98695592
83	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.96206013
84	CTP biosynthetic process (GO:0006241)	2.93483806
85	CTP metabolic process (GO:0046036)	2.93483806
86	methionine biosynthetic process (GO:0009086)	2.92289610
87	ribosomal large subunit biogenesis (GO:0042273)	2.91782864
88	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.91337897
89	rRNA modification (GO:0000154)	2.91272272
90	translational elongation (GO:0006414)	2.91209815
91	nucleoside triphosphate biosynthetic process (GO:0009142)	2.91084273
92	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.90588022
93	maturation of SSU-rRNA (GO:0030490)	2.90102073
94	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	2.89307410
95	translational initiation (GO:0006413)	2.88159289
96	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.88135334
97	DNA demethylation (GO:0080111)	2.85078487
98	protein localization to endoplasmic reticulum (GO:0070972)	2.84357492
99	cellular component biogenesis (GO:0044085)	2.83174102
100	cytochrome complex assembly (GO:0017004)	2.83140860

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.17858349
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.67969554
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.37154185
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.25752260
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.06394597
6	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.94854060
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.92841532
8	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.81522949
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.65068617
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.51393849
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.47493207
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.46708011
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.43894196
14	FUS_26573619_Chip-Seq_HEK293_Human	2.36688151
15	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.27556631
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.26153217
17	VDR_22108803_ChIP-Seq_LS180_Human	2.21410418
18	TP53_22573176_ChIP-Seq_HFKS_Human	2.11998053
19	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.09915968
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.09565826
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.03336498
22	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.99061325
23	EWS_26573619_Chip-Seq_HEK293_Human	1.96836813
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.96051251
25	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.93620254
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.91777738
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.89170459
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.81750181
29	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.78411498
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.75377651
31	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.70159262
32	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.68741906
33	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.68095958
34	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.67115648
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.65314761
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.61287572
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.56471777
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.56160592
39	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.53422534
40	P300_19829295_ChIP-Seq_ESCs_Human	1.49443591
41	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.49428814
42	GBX2_23144817_ChIP-Seq_PC3_Human	1.49084762
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.46559350
44	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.46476725
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46352514
46	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.45728274
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.44203259
48	DCP1A_22483619_ChIP-Seq_HELA_Human	1.36315616
49	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.29431852
50	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.26836988
51	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.26618788
52	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.26357613
53	NCOR_22424771_ChIP-Seq_293T_Human	1.25039674
54	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.24470630
55	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.20835367
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20819382
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20819382
58	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20347610
59	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.17992195
60	RNF2_27304074_Chip-Seq_NSC_Mouse	1.17719337
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15334898
62	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.11928986
63	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.10218086
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08272660
65	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07613099
66	ZNF263_19887448_ChIP-Seq_K562_Human	1.07447213
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07059128
68	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07059128
69	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.06685914
70	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.04286949
71	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03375189
72	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.03231220
73	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.03226641
74	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.02593520
75	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.01034184
76	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.98303616
77	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.97806314
78	PHF8_20622853_ChIP-Seq_HELA_Human	0.97498149
79	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.92736550
80	HTT_18923047_ChIP-ChIP_STHdh_Human	0.92081632
81	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.90382108
82	NANOG_20526341_ChIP-Seq_ESCs_Human	0.89774950
83	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.89655219
84	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.89194076
85	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.88790169
86	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.87690085
87	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.86322665
88	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.84954598
89	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.84059750
90	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.83255690
91	CBP_20019798_ChIP-Seq_JUKART_Human	0.83255690
92	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.82168872
93	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.80458742
94	P53_21459846_ChIP-Seq_SAOS-2_Human	0.80141175
95	TCF4_22108803_ChIP-Seq_LS180_Human	0.80005503
96	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.78074565
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.77763058
98	CDX2_22108803_ChIP-Seq_LS180_Human	0.76761164
99	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.76491767
100	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.76199536

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002254_reproductive_system_inflammat	5.86165609
2	MP0000537_abnormal_urethra_morphology	4.63785674
3	MP0003315_abnormal_perineum_morphology	4.40742912
4	MP0003136_yellow_coat_color	4.18042510
5	MP0000516_abnormal_urinary_system	4.03798971
6	MP0005367_renal/urinary_system_phenotyp	4.03798971
7	MP0005187_abnormal_penis_morphology	3.66659612
8	MP0008995_early_reproductive_senescence	3.34534933
9	MP0005645_abnormal_hypothalamus_physiol	3.04001024
10	MP0003880_abnormal_central_pattern	2.57498489
11	MP0008877_abnormal_DNA_methylation	2.46152556
12	MP0003786_premature_aging	2.21693743
13	MP0003937_abnormal_limbs/digits/tail_de	2.13865919
14	MP0002938_white_spotting	2.13345435
15	MP0003121_genomic_imprinting	2.06241050
16	MP0000372_irregular_coat_pigmentation	1.95784525
17	MP0003122_maternal_imprinting	1.91260274
18	MP0002163_abnormal_gland_morphology	1.86054932
19	MP0008007_abnormal_cellular_replicative	1.83872356
20	MP0006292_abnormal_olfactory_placode	1.78613199
21	MP0008058_abnormal_DNA_repair	1.69302254
22	MP0003806_abnormal_nucleotide_metabolis	1.58314627
23	MP0003186_abnormal_redox_activity	1.52939417
24	MP0005075_abnormal_melanosome_morpholog	1.52353078
25	MP0000538_abnormal_urinary_bladder	1.51966782
26	MP0001984_abnormal_olfaction	1.50428808
27	MP0005423_abnormal_somatic_nervous	1.50153790
28	MP0010030_abnormal_orbit_morphology	1.50102578
29	MP0001293_anophthalmia	1.42821596
30	MP0002736_abnormal_nociception_after	1.42083720
31	MP0005084_abnormal_gallbladder_morpholo	1.39381601
32	MP0005551_abnormal_eye_electrophysiolog	1.33517725
33	MP0002138_abnormal_hepatobiliary_system	1.31951181
34	MP0004145_abnormal_muscle_electrophysio	1.31828542
35	MP0004484_altered_response_of	1.28793048
36	MP0001485_abnormal_pinna_reflex	1.27994390
37	MP0002876_abnormal_thyroid_physiology	1.27169475
38	MP0003385_abnormal_body_wall	1.24604341
39	MP0009379_abnormal_foot_pigmentation	1.22925027
40	MP0000049_abnormal_middle_ear	1.19828731
41	MP0002090_abnormal_vision	1.16889426
42	MP0003787_abnormal_imprinting	1.14711165
43	MP0009250_abnormal_appendicular_skeleto	1.11336354
44	MP0001502_abnormal_circadian_rhythm	1.10596951
45	MP0005379_endocrine/exocrine_gland_phen	1.07770661
46	MP0000613_abnormal_salivary_gland	1.07617861
47	MP0004133_heterotaxia	1.04300991
48	MP0002837_dystrophic_cardiac_calcinosis	1.02673544
49	MP0003123_paternal_imprinting	1.01847477
50	MP0006035_abnormal_mitochondrial_morpho	1.00709415
51	MP0002653_abnormal_ependyma_morphology	0.97866866
52	MP0002132_abnormal_respiratory_system	0.97128999
53	MP0004381_abnormal_hair_follicle	0.90471839
54	MP0001119_abnormal_female_reproductive	0.86966579
55	MP0003942_abnormal_urinary_system	0.86142902
56	MP0002095_abnormal_skin_pigmentation	0.86090496
57	MP0003693_abnormal_embryo_hatching	0.86027904
58	MP0003191_abnormal_cellular_cholesterol	0.85657190
59	MP0003567_abnormal_fetal_cardiomyocyte	0.85036171
60	MP0000428_abnormal_craniofacial_morphol	0.84178409
61	MP0003283_abnormal_digestive_organ	0.83499637
62	MP0001968_abnormal_touch/_nociception	0.82183769
63	MP0008872_abnormal_physiological_respon	0.81856825
64	MP0008875_abnormal_xenobiotic_pharmacok	0.80770962
65	MP0001764_abnormal_homeostasis	0.78238763
66	MP0001666_abnormal_nutrient_absorption	0.78205231
67	MP0005646_abnormal_pituitary_gland	0.74637687
68	MP0004885_abnormal_endolymph	0.74325130
69	MP0009046_muscle_twitch	0.71644202
70	MP0002109_abnormal_limb_morphology	0.70257945
71	MP0003646_muscle_fatigue	0.66990828
72	MP0003935_abnormal_craniofacial_develop	0.66127282
73	MP0000778_abnormal_nervous_system	0.65914481
74	MP0003011_delayed_dark_adaptation	0.64047725
75	MP0002160_abnormal_reproductive_system	0.63703084
76	MP0003111_abnormal_nucleus_morphology	0.63496076
77	MP0002295_abnormal_pulmonary_circulatio	0.63353887
78	MP0006036_abnormal_mitochondrial_physio	0.63142774
79	MP0005636_abnormal_mineral_homeostasis	0.62875675
80	MP0008961_abnormal_basal_metabolism	0.62425135
81	MP0001664_abnormal_digestion	0.62121056
82	MP0002282_abnormal_trachea_morphology	0.61805601
83	MP0000750_abnormal_muscle_regeneration	0.61731560
84	MP0002115_abnormal_skeleton_extremities	0.61727527
85	MP0004019_abnormal_vitamin_homeostasis	0.61215852
86	MP0005166_decreased_susceptibility_to	0.60978582
87	MP0005085_abnormal_gallbladder_physiolo	0.60527051
88	MP0009780_abnormal_chondrocyte_physiolo	0.60197800
89	MP0002234_abnormal_pharynx_morphology	0.60094281
90	MP0005409_darkened_coat_color	0.59502673
91	MP0005253_abnormal_eye_physiology	0.58294517
92	MP0001324_abnormal_eye_pigmentation	0.56888585
93	MP0002139_abnormal_hepatobiliary_system	0.55942091
94	MP0005365_abnormal_bile_salt	0.55731597
95	MP0000631_abnormal_neuroendocrine_gland	0.55446645
96	MP0002751_abnormal_autonomic_nervous	0.55339126
97	MP0002638_abnormal_pupillary_reflex	0.55218519
98	MP0000653_abnormal_sex_gland	0.55064432
99	MP0005197_abnormal_uvea_morphology	0.54668263
100	MP0002277_abnormal_respiratory_mucosa	0.54655328

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	5.93394688
2	Short 1st metacarpal (HP:0010034)	5.93394688
3	3-Methylglutaconic aciduria (HP:0003535)	5.89678409
4	Abnormal tarsal ossification (HP:0008369)	5.56267561
5	Septate vagina (HP:0001153)	5.29616258
6	Abnormality of the 1st metacarpal (HP:0010009)	5.24483864
7	Spontaneous abortion (HP:0005268)	5.23112402
8	Abnormality of the 2nd finger (HP:0004100)	4.21508078
9	Short phalanx of the thumb (HP:0009660)	3.79715027
10	Ureteral stenosis (HP:0000071)	3.76291819
11	Unilateral renal agenesis (HP:0000122)	3.63287178
12	Acute encephalopathy (HP:0006846)	3.57628820
13	Abnormal foot bone ossification (HP:0010675)	3.54923123
14	Short 5th finger (HP:0009237)	3.49393154
15	Ureteral obstruction (HP:0006000)	3.45758427
16	Acute necrotizing encephalopathy (HP:0006965)	3.34479442
17	Septo-optic dysplasia (HP:0100842)	3.28891272
18	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	3.25334220
19	Cerebral hypomyelination (HP:0006808)	3.25243183
20	Abnormal mitochondria in muscle tissue (HP:0008316)	3.17302603
21	Short tibia (HP:0005736)	3.17020982
22	Short hallux (HP:0010109)	3.14203908
23	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.04655858
24	Pancreatic cysts (HP:0001737)	3.03744018
25	Cleft eyelid (HP:0000625)	3.00135987
26	Abnormality of carpal bone ossification (HP:0006257)	2.96109273
27	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.96067062
28	Mitochondrial inheritance (HP:0001427)	2.95557432
29	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	2.93277025
30	Absent eyebrow (HP:0002223)	2.85319096
31	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.82094588
32	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.82094588
33	Progressive macrocephaly (HP:0004481)	2.81580219
34	Midline defect of the nose (HP:0004122)	2.80598521
35	Abnormality of midbrain morphology (HP:0002418)	2.79036231
36	Molar tooth sign on MRI (HP:0002419)	2.79036231
37	Congenital stationary night blindness (HP:0007642)	2.70790239
38	Concave nail (HP:0001598)	2.69748153
39	Increased CSF lactate (HP:0002490)	2.68139678
40	True hermaphroditism (HP:0010459)	2.63701338
41	Maternal diabetes (HP:0009800)	2.48689674
42	Type I transferrin isoform profile (HP:0003642)	2.48271208
43	Pancreatic fibrosis (HP:0100732)	2.39590638
44	Methylmalonic acidemia (HP:0002912)	2.37348317
45	Cerebral edema (HP:0002181)	2.37159332
46	Delusions (HP:0000746)	2.35534085
47	Abnormal hand bone ossification (HP:0010660)	2.34983361
48	Shawl scrotum (HP:0000049)	2.34968558
49	Hepatocellular necrosis (HP:0001404)	2.29946072
50	Increased serum lactate (HP:0002151)	2.29865297
51	Hyperglycinemia (HP:0002154)	2.29334401
52	Synostosis of carpal bones (HP:0005048)	2.27435970
53	Truncus arteriosus (HP:0001660)	2.23706309
54	Colon cancer (HP:0003003)	2.23527736
55	Abnormality of the musculature of the hand (HP:0001421)	2.17651893
56	Optic disc pallor (HP:0000543)	2.17239951
57	Ulnar deviation of finger (HP:0009465)	2.14630019
58	Lactic acidosis (HP:0003128)	2.09416833
59	Cystic liver disease (HP:0006706)	2.04472976
60	Abnormality of magnesium homeostasis (HP:0004921)	2.03719389
61	Hepatic necrosis (HP:0002605)	2.03000823
62	Abnormal ossification of hand bones (HP:0005921)	2.01435448
63	Abnormality of cells of the erythroid lineage (HP:0012130)	2.00963498
64	Renal Fanconi syndrome (HP:0001994)	1.99505523
65	Macrocytic anemia (HP:0001972)	1.99298795
66	Short thumb (HP:0009778)	1.97569290
67	Increased intramyocellular lipid droplets (HP:0012240)	1.95929682
68	Nephronophthisis (HP:0000090)	1.95638661
69	Hypoplasia of the uterus (HP:0000013)	1.95076736
70	Patent foramen ovale (HP:0001655)	1.93951292
71	Flat capital femoral epiphysis (HP:0003370)	1.92924097
72	Short middle phalanx of finger (HP:0005819)	1.91960288
73	Sacral dimple (HP:0000960)	1.90687604
74	Microretrognathia (HP:0000308)	1.89624986
75	Abnormal number of erythroid precursors (HP:0012131)	1.89236263
76	Abnormality of alanine metabolism (HP:0010916)	1.89147222
77	Hyperalaninemia (HP:0003348)	1.89147222
78	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.89147222
79	Hypomagnesemia (HP:0002917)	1.88825861
80	Emotional lability (HP:0000712)	1.88374926
81	Unsteady gait (HP:0002317)	1.88193514
82	Aplasia/hypoplasia of the uterus (HP:0008684)	1.83396328
83	Lethargy (HP:0001254)	1.83107751
84	CNS demyelination (HP:0007305)	1.79958339
85	CNS hypomyelination (HP:0003429)	1.79954081
86	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.79088675
87	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.78896163
88	Abnormal protein N-linked glycosylation (HP:0012347)	1.78896163
89	Abnormal protein glycosylation (HP:0012346)	1.78896163
90	Abnormal glycosylation (HP:0012345)	1.78896163
91	Type II lissencephaly (HP:0007260)	1.76919999
92	Dyschromatopsia (HP:0007641)	1.75786876
93	Occipital encephalocele (HP:0002085)	1.73453913
94	Gout (HP:0001997)	1.73440841
95	Chronic hepatic failure (HP:0100626)	1.72746848
96	Polydipsia (HP:0001959)	1.72662973
97	Abnormal drinking behavior (HP:0030082)	1.72662973
98	Absent hair (HP:0002298)	1.72470015
99	Optic nerve hypoplasia (HP:0000609)	1.72269460
100	Sclerocornea (HP:0000647)	1.70995060

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.64175592
2	TRIM28	5.13158558
3	SIK3	3.41526596
4	ZAK	3.31414100
5	PINK1	2.79929035
6	GRK1	2.60512464
7	BCKDK	2.41068207
8	TNIK	2.33490076
9	WNK4	2.28277484
10	STK16	2.22886628
11	BMPR1B	2.09058664
12	BCR	2.05622072
13	DYRK2	1.96674873
14	VRK2	1.95310446
15	FRK	1.82485420
16	LATS2	1.74297786
17	NUAK1	1.67612684
18	ADRBK2	1.57605505
19	FES	1.44844557
20	PRKD3	1.39536734
21	CAMK2D	1.37442831
22	RPS6KB1	1.34631837
23	INSRR	1.34329802
24	VRK1	1.27070741
25	OXSR1	1.23408540
26	DMPK	1.22288973
27	PDK2	1.19411668
28	DAPK2	1.16304779
29	NME2	1.03550541
30	MAPK13	1.02704732
31	EIF2AK1	1.00662416
32	MINK1	1.00307867
33	NLK	1.00112447
34	MAP4K1	0.99005935
35	AKT3	0.98166046
36	RPS6KA4	0.97975001
37	PLK3	0.97534370
38	ATR	0.95053441
39	MAP3K12	0.93980924
40	MARK1	0.91498620
41	PHKG1	0.90733278
42	PHKG2	0.90733278
43	STK39	0.88516522
44	SRPK1	0.85751864
45	TGFBR1	0.80736749
46	DAPK3	0.80276686
47	NTRK3	0.80005752
48	LRRK2	0.79345736
49	PRKCG	0.74837482
50	ILK	0.72945333
51	EPHB2	0.70206020
52	PAK3	0.70129612
53	CDK3	0.68807799
54	PRKCH	0.68195276
55	BUB1	0.67450811
56	OBSCN	0.66997826
57	TAF1	0.65634895
58	CAMK1D	0.64462605
59	DAPK1	0.61645919
60	TLK1	0.61062167
61	WNK3	0.59445973
62	PRKCE	0.58955377
63	CSNK2A1	0.57396161
64	MST1R	0.56235157
65	ABL2	0.52424638
66	PBK	0.51713565
67	ADRBK1	0.49010691
68	CSNK1A1	0.48423837
69	KSR1	0.48100879
70	CDK19	0.47965630
71	CAMKK2	0.47518084
72	NEK9	0.47144664
73	GRK5	0.45305360
74	STK11	0.45024471
75	MUSK	0.44877293
76	CSNK1G1	0.44722288
77	PLK1	0.44507646
78	PRKACA	0.42239110
79	TNK2	0.42099413
80	STK4	0.40953189
81	EIF2AK2	0.40772037
82	MAP3K4	0.39971027
83	STK3	0.38456326
84	CSNK1G3	0.38156573
85	MAP3K2	0.37885519
86	ABL1	0.36990608
87	PRKCB	0.36961709
88	TIE1	0.36955782
89	TYRO3	0.36904011
90	CAMK1G	0.36865753
91	CSNK1E	0.35214582
92	CDK7	0.33482476
93	PRKG1	0.32522784
94	PIK3CA	0.32470466
95	PRKCA	0.32137377
96	PRKDC	0.31288100
97	PKN1	0.31254231
98	CAMK1	0.31119378
99	CSNK2A2	0.30806659
100	PTK2B	0.30009588

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.92070683
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.17028144
3	RNA polymerase_Homo sapiens_hsa03020	2.88977807
4	Basal transcription factors_Homo sapiens_hsa03022	2.79435151
5	Caffeine metabolism_Homo sapiens_hsa00232	2.67772183
6	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.52828692
7	Parkinsons disease_Homo sapiens_hsa05012	2.46924438
8	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.30948596
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.26383596
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.24307356
11	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.22961884
12	One carbon pool by folate_Homo sapiens_hsa00670	2.15981184
13	Proteasome_Homo sapiens_hsa03050	2.12050431
14	Homologous recombination_Homo sapiens_hsa03440	2.00674284
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.82591196
16	Huntingtons disease_Homo sapiens_hsa05016	1.78397421
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.76844943
18	Pyrimidine metabolism_Homo sapiens_hsa00240	1.70194261
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.66796726
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.64644276
21	Protein export_Homo sapiens_hsa03060	1.62709248
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.61551518
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.61459798
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.61161146
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.60093267
26	Alzheimers disease_Homo sapiens_hsa05010	1.59851837
27	DNA replication_Homo sapiens_hsa03030	1.56210533
28	Phototransduction_Homo sapiens_hsa04744	1.51187062
29	Olfactory transduction_Homo sapiens_hsa04740	1.49810249
30	Spliceosome_Homo sapiens_hsa03040	1.46638934
31	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.44872700
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40597657
33	Non-homologous end-joining_Homo sapiens_hsa03450	1.40482927
34	Mismatch repair_Homo sapiens_hsa03430	1.34313421
35	Propanoate metabolism_Homo sapiens_hsa00640	1.31775050
36	RNA transport_Homo sapiens_hsa03013	1.31548678
37	Fat digestion and absorption_Homo sapiens_hsa04975	1.30882322
38	Base excision repair_Homo sapiens_hsa03410	1.26719988
39	Sulfur metabolism_Homo sapiens_hsa00920	1.20648497
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.19203846
41	RNA degradation_Homo sapiens_hsa03018	1.18230385
42	Nitrogen metabolism_Homo sapiens_hsa00910	1.17297133
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.16864012
44	Purine metabolism_Homo sapiens_hsa00230	1.16130478
45	Cardiac muscle contraction_Homo sapiens_hsa04260	1.05363166
46	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.03673207
47	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.02532431
48	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.98868478
49	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.96673602
50	Fatty acid elongation_Homo sapiens_hsa00062	0.90919290
51	Peroxisome_Homo sapiens_hsa04146	0.84757232
52	Taste transduction_Homo sapiens_hsa04742	0.81901859
53	Sulfur relay system_Homo sapiens_hsa04122	0.80790709
54	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.80477697
55	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.80361151
56	Metabolic pathways_Homo sapiens_hsa01100	0.77944400
57	Wnt signaling pathway_Homo sapiens_hsa04310	0.76719749
58	Basal cell carcinoma_Homo sapiens_hsa05217	0.76391219
59	Retinol metabolism_Homo sapiens_hsa00830	0.75180295
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74787214
61	Regulation of autophagy_Homo sapiens_hsa04140	0.74300086
62	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.72815745
63	Insulin secretion_Homo sapiens_hsa04911	0.72556728
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69995284
65	Mineral absorption_Homo sapiens_hsa04978	0.68369659
66	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.66602468
67	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.63823761
68	Gastric acid secretion_Homo sapiens_hsa04971	0.60136590
69	Oocyte meiosis_Homo sapiens_hsa04114	0.59765750
70	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.59284652
71	ABC transporters_Homo sapiens_hsa02010	0.58847106
72	Circadian rhythm_Homo sapiens_hsa04710	0.58714639
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.57837605
74	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.57060757
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57016232
76	Butanoate metabolism_Homo sapiens_hsa00650	0.56862509
77	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.53132170
78	Asthma_Homo sapiens_hsa05310	0.52969902
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.52435237
80	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52197811
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.50241083
82	Circadian entrainment_Homo sapiens_hsa04713	0.48092520
83	Tyrosine metabolism_Homo sapiens_hsa00350	0.48080066
84	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.46470660
85	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.44406512
86	Tryptophan metabolism_Homo sapiens_hsa00380	0.42691774
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.42095556
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40151008
89	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.38976636
90	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.38875243
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.37676602
92	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.35976432
93	Glucagon signaling pathway_Homo sapiens_hsa04922	0.35612283
94	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.35063133
95	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.32545276
96	Pyruvate metabolism_Homo sapiens_hsa00620	0.30763274
97	Pentose phosphate pathway_Homo sapiens_hsa00030	0.29110849
98	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.26773058
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.25693515
100	Amphetamine addiction_Homo sapiens_hsa05031	0.25345815

MORF4L1P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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