

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | cell wall macromolecule catabolic process (GO:0016998) | 9.03345985 |
| 2 | cell wall macromolecule metabolic process (GO:0044036) | 9.03345985 |
| 3 | fusion of sperm to egg plasma membrane (GO:0007342) | 8.50905389 |
| 4 | sperm motility (GO:0030317) | 8.32793968 |
| 5 | axonemal dynein complex assembly (GO:0070286) | 8.27518088 |
| 6 | cilium or flagellum-dependent cell motility (GO:0001539) | 8.26531942 |
| 7 | epithelial cilium movement (GO:0003351) | 7.86478592 |
| 8 | acrosome reaction (GO:0007340) | 7.59276453 |
| 9 | cilium movement (GO:0003341) | 7.31838367 |
| 10 | sperm-egg recognition (GO:0035036) | 7.17540592 |
| 11 | multicellular organism reproduction (GO:0032504) | 7.07937518 |
| 12 | acrosome assembly (GO:0001675) | 6.92975855 |
| 13 | motile cilium assembly (GO:0044458) | 6.50847058 |
| 14 | binding of sperm to zona pellucida (GO:0007339) | 6.44514259 |
| 15 | plasma membrane fusion (GO:0045026) | 6.43177416 |
| 16 | regulation of cilium movement (GO:0003352) | 6.38003210 |
| 17 | cell-cell recognition (GO:0009988) | 6.23230965 |
| 18 | spermatid development (GO:0007286) | 6.19917853 |
| 19 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 6.07237560 |
| 20 | reproduction (GO:0000003) | 5.97940688 |
| 21 | intraciliary transport (GO:0042073) | 5.15407482 |
| 22 | single fertilization (GO:0007338) | 5.07553171 |
| 23 | male meiosis (GO:0007140) | 5.06321585 |
| 24 | GTP biosynthetic process (GO:0006183) | 5.02938902 |
| 25 | sperm capacitation (GO:0048240) | 5.01934680 |
| 26 | piRNA metabolic process (GO:0034587) | 4.49079926 |
| 27 | synaptonemal complex organization (GO:0070193) | 4.40922413 |
| 28 | spermatid nucleus differentiation (GO:0007289) | 4.37515886 |
| 29 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.33371399 |
| 30 | protein localization to cilium (GO:0061512) | 4.30299947 |
| 31 | UTP biosynthetic process (GO:0006228) | 4.23666794 |
| 32 | organic cation transport (GO:0015695) | 4.19784370 |
| 33 | calcium ion-dependent exocytosis (GO:0017156) | 4.19562917 |
| 34 | guanosine-containing compound biosynthetic process (GO:1901070) | 4.17261993 |
| 35 | nucleoside diphosphate phosphorylation (GO:0006165) | 4.15995385 |
| 36 | ventricular system development (GO:0021591) | 4.14962346 |
| 37 | negative regulation of inclusion body assembly (GO:0090084) | 4.13476644 |
| 38 | fertilization (GO:0009566) | 4.07057233 |
| 39 | synaptonemal complex assembly (GO:0007130) | 4.06467918 |
| 40 | axoneme assembly (GO:0035082) | 4.03779377 |
| 41 | regulation of microtubule-based movement (GO:0060632) | 4.01601496 |
| 42 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.98733097 |
| 43 | microtubule severing (GO:0051013) | 3.97525323 |
| 44 | regulation of inclusion body assembly (GO:0090083) | 3.92208233 |
| 45 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.84486837 |
| 46 | ATP synthesis coupled proton transport (GO:0015986) | 3.84486837 |
| 47 | sequestering of actin monomers (GO:0042989) | 3.77446289 |
| 48 | spermatogenesis (GO:0007283) | 3.73780578 |
| 49 | male gamete generation (GO:0048232) | 3.72543394 |
| 50 | electron transport chain (GO:0022900) | 3.70400549 |
| 51 | UTP metabolic process (GO:0046051) | 3.68059665 |
| 52 | respiratory electron transport chain (GO:0022904) | 3.67397072 |
| 53 | nonmotile primary cilium assembly (GO:0035058) | 3.66776422 |
| 54 | CTP metabolic process (GO:0046036) | 3.59942842 |
| 55 | CTP biosynthetic process (GO:0006241) | 3.59942842 |
| 56 | chaperone-mediated protein transport (GO:0072321) | 3.58867521 |
| 57 | left/right axis specification (GO:0070986) | 3.57382545 |
| 58 | cilium organization (GO:0044782) | 3.54852273 |
| 59 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.49889561 |
| 60 | cilium assembly (GO:0042384) | 3.49826580 |
| 61 | protein complex biogenesis (GO:0070271) | 3.46347593 |
| 62 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.44529200 |
| 63 | glycerol ether metabolic process (GO:0006662) | 3.42763937 |
| 64 | gamete generation (GO:0007276) | 3.42728579 |
| 65 | protein polyglutamylation (GO:0018095) | 3.39431280 |
| 66 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.38775290 |
| 67 | microtubule bundle formation (GO:0001578) | 3.30418159 |
| 68 | neuron fate determination (GO:0048664) | 3.30115634 |
| 69 | microtubule-based movement (GO:0007018) | 3.27209270 |
| 70 | ether metabolic process (GO:0018904) | 3.26521405 |
| 71 | germ cell development (GO:0007281) | 3.25358176 |
| 72 | proteasome assembly (GO:0043248) | 3.24865247 |
| 73 | DNA methylation involved in gamete generation (GO:0043046) | 3.21568975 |
| 74 | cell recognition (GO:0008037) | 3.21285166 |
| 75 | cilium morphogenesis (GO:0060271) | 3.16583992 |
| 76 | microtubule depolymerization (GO:0007019) | 3.15335427 |
| 77 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.14950852 |
| 78 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.14950852 |
| 79 | NADH dehydrogenase complex assembly (GO:0010257) | 3.14950852 |
| 80 | male meiosis I (GO:0007141) | 3.14702333 |
| 81 | daunorubicin metabolic process (GO:0044597) | 3.13400758 |
| 82 | polyketide metabolic process (GO:0030638) | 3.13400758 |
| 83 | doxorubicin metabolic process (GO:0044598) | 3.13400758 |
| 84 | single strand break repair (GO:0000012) | 3.13124802 |
| 85 | centriole assembly (GO:0098534) | 3.11877483 |
| 86 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 3.11343033 |
| 87 | hydrogen ion transmembrane transport (GO:1902600) | 3.10656208 |
| 88 | centriole replication (GO:0007099) | 3.09351587 |
| 89 | cellular process involved in reproduction in multicellular organism (GO:0022412) | 3.08513412 |
| 90 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.07715734 |
| 91 | ATP biosynthetic process (GO:0006754) | 3.06161178 |
| 92 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.05817260 |
| 93 | smoothened signaling pathway (GO:0007224) | 3.04215962 |
| 94 | cullin deneddylation (GO:0010388) | 2.95179657 |
| 95 | cellular component assembly involved in morphogenesis (GO:0010927) | 2.93897837 |
| 96 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.93598457 |
| 97 | determination of left/right symmetry (GO:0007368) | 2.93324777 |
| 98 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.93300156 |
| 99 | platelet dense granule organization (GO:0060155) | 2.88023269 |
| 100 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 2.87480678 |
| 101 | ATP hydrolysis coupled proton transport (GO:0015991) | 2.87480678 |
| 102 | left/right pattern formation (GO:0060972) | 2.84689401 |
| 103 | protein neddylation (GO:0045116) | 2.81927036 |
| 104 | cell projection assembly (GO:0030031) | 2.81482713 |
| 105 | determination of bilateral symmetry (GO:0009855) | 2.80622116 |
| 106 | protein refolding (GO:0042026) | 2.79856668 |
| 107 | specification of symmetry (GO:0009799) | 2.77403625 |
| 108 | pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208) | 2.76657922 |
| 109 | lactate metabolic process (GO:0006089) | 2.76308336 |
| 110 | deoxyribonucleoside diphosphate metabolic process (GO:0009186) | 2.72128173 |
| 111 | proton transport (GO:0015992) | 2.71760946 |
| 112 | meiotic nuclear division (GO:0007126) | 2.70781844 |
| 113 | regulation of mitochondrial translation (GO:0070129) | 2.70301772 |
| 114 | inner mitochondrial membrane organization (GO:0007007) | 2.69129611 |
| 115 | respiratory chain complex IV assembly (GO:0008535) | 2.68569400 |
| 116 | microtubule polymerization or depolymerization (GO:0031109) | 2.67539034 |
| 117 | protein deneddylation (GO:0000338) | 2.64435464 |
| 118 | glutathione derivative metabolic process (GO:1901685) | 2.58993048 |
| 119 | glutathione derivative biosynthetic process (GO:1901687) | 2.58993048 |
| 120 | organelle disassembly (GO:1903008) | 2.55985412 |
| 121 | aldehyde catabolic process (GO:0046185) | 2.46411887 |
| 122 | hydrogen transport (GO:0006818) | 2.43441578 |
| 123 | cotranslational protein targeting to membrane (GO:0006613) | 2.43137859 |
| 124 | terpenoid biosynthetic process (GO:0016114) | 2.41512229 |
| 125 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.39787126 |
| 126 | transmission of nerve impulse (GO:0019226) | 2.36754236 |
| 127 | DNA damage response, detection of DNA damage (GO:0042769) | 2.35744783 |
| 128 | behavioral response to nicotine (GO:0035095) | 2.34367191 |
| 129 | protein targeting to ER (GO:0045047) | 2.34283577 |
| 130 | chromatin remodeling at centromere (GO:0031055) | 2.33440628 |
| 131 | CENP-A containing nucleosome assembly (GO:0034080) | 2.33149522 |
| 132 | primary alcohol catabolic process (GO:0034310) | 2.32833795 |
| 133 | positive regulation of mitochondrial fission (GO:0090141) | 2.32161487 |
| 134 | viral transcription (GO:0019083) | 2.31992625 |
| 135 | translational termination (GO:0006415) | 2.30707175 |
| 136 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.30191206 |
| 137 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.30191206 |
| 138 | retinal ganglion cell axon guidance (GO:0031290) | 2.30186355 |
| 139 | photoreceptor cell maintenance (GO:0045494) | 2.29754401 |
| 140 | protein-cofactor linkage (GO:0018065) | 2.28559897 |
| 141 | cytochrome complex assembly (GO:0017004) | 2.26708550 |
| 142 | nucleotide phosphorylation (GO:0046939) | 2.26649578 |
| 143 | intracellular protein transmembrane import (GO:0044743) | 2.26166659 |
| 144 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.25399878 |
| 145 | peptidyl-histidine modification (GO:0018202) | 2.25329794 |
| 146 | presynaptic membrane assembly (GO:0097105) | 2.23966883 |
| 147 | histone H2A acetylation (GO:0043968) | 2.23710832 |
| 148 | protein localization to endoplasmic reticulum (GO:0070972) | 2.22687319 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 4.73624323 |
| 2 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.65665867 |
| 3 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.93248064 |
| 4 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.78329801 |
| 5 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.69073904 |
| 6 | VDR_22108803_ChIP-Seq_LS180_Human | 2.47545898 |
| 7 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.20759954 |
| 8 | EWS_26573619_Chip-Seq_HEK293_Human | 2.15597844 |
| 9 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.14424926 |
| 10 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.13138998 |
| 11 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.05951122 |
| 12 | * RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 2.03044568 |
| 13 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.02481183 |
| 14 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.94354804 |
| 15 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.91908140 |
| 16 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.90705783 |
| 17 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.86542240 |
| 18 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.85333203 |
| 19 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.85199798 |
| 20 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.83832603 |
| 21 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.78465064 |
| 22 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.77916765 |
| 23 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.71711383 |
| 24 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.71036742 |
| 25 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.65651889 |
| 26 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.63801386 |
| 27 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.63192559 |
| 28 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.63102319 |
| 29 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.62737249 |
| 30 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.61307304 |
| 31 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.61207357 |
| 32 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.59140560 |
| 33 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.57380418 |
| 34 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.56419740 |
| 35 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.54042486 |
| 36 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.49415991 |
| 37 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.48612331 |
| 38 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.47145314 |
| 39 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.46183955 |
| 40 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.44970185 |
| 41 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.43048118 |
| 42 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.39583052 |
| 43 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.39290707 |
| 44 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.39033142 |
| 45 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.37856214 |
| 46 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.37723889 |
| 47 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.36837520 |
| 48 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.36057431 |
| 49 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.35329916 |
| 50 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.34305236 |
| 51 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.31489632 |
| 52 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.31466360 |
| 53 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.30917114 |
| 54 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.28241717 |
| 55 | KDM2B_26808549_Chip-Seq_REH_Human | 1.28089637 |
| 56 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.27342921 |
| 57 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.26874376 |
| 58 | * SOX2_22085726_ChIP-Seq_NPCs_Mouse | 1.26468179 |
| 59 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.25373195 |
| 60 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.25226098 |
| 61 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 1.24983753 |
| 62 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.24838486 |
| 63 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.23148641 |
| 64 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.23010356 |
| 65 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.22631733 |
| 66 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.22310636 |
| 67 | FUS_26573619_Chip-Seq_HEK293_Human | 1.20850047 |
| 68 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.20310239 |
| 69 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.18629872 |
| 70 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.17998392 |
| 71 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.17998392 |
| 72 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.17787818 |
| 73 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.17650329 |
| 74 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.17639440 |
| 75 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.16475723 |
| 76 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.15843380 |
| 77 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.15734764 |
| 78 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.15696455 |
| 79 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.15410549 |
| 80 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.15192748 |
| 81 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.15031125 |
| 82 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.14876484 |
| 83 | GATA3_21867929_ChIP-Seq_CD8_Mouse | 1.14558758 |
| 84 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.12583882 |
| 85 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.11836640 |
| 86 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.11150803 |
| 87 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.10443194 |
| 88 | AR_25329375_ChIP-Seq_VCAP_Human | 1.10337228 |
| 89 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.10312216 |
| 90 | STAT1_17558387_ChIP-Seq_HELA_Human | 1.10056068 |
| 91 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.09347840 |
| 92 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.08882995 |
| 93 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.08568217 |
| 94 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.08506395 |
| 95 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.08103085 |
| 96 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.07649200 |
| 97 | * P300_19829295_ChIP-Seq_ESCs_Human | 1.06976885 |
| 98 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.06573277 |
| 99 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.06221013 |
| 100 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.06207844 |
| 101 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.05696217 |
| 102 | GATA3_21867929_ChIP-Seq_TH1_Mouse | 1.05461539 |
| 103 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.04849793 |
| 104 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.04255460 |
| 105 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.04123779 |
| 106 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 1.04008717 |
| 107 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.03676560 |
| 108 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.03472970 |
| 109 | KLF4_18555785_Chip-Seq_ESCs_Mouse | 1.03103263 |
| 110 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.02427894 |
| 111 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.02405417 |
| 112 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 1.01485765 |
| 113 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.00957348 |
| 114 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.00821654 |
| 115 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.00821654 |
| 116 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.00572020 |
| 117 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.00324263 |
| 118 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.00249543 |
| 119 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.99217546 |
| 120 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.98873144 |
| 121 | GABP_19822575_ChIP-Seq_HepG2_Human | 0.98414350 |
| 122 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.98346770 |
| 123 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.98325959 |
| 124 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.98321105 |
| 125 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.97685524 |
| 126 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.97459382 |
| 127 | JUN_21703547_ChIP-Seq_K562_Human | 0.97224699 |
| 128 | * NANOG_19829295_ChIP-Seq_ESCs_Human | 0.97204573 |
| 129 | * SOX2_19829295_ChIP-Seq_ESCs_Human | 0.97204573 |
| 130 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 0.96672492 |
| 131 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.96658194 |
| 132 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.96658194 |
| 133 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.95975952 |
| 134 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.95453215 |
| 135 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.95251759 |
| 136 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.95215523 |
| 137 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 0.94995092 |
| 138 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.94917393 |
| 139 | NCOR_22424771_ChIP-Seq_293T_Human | 0.94200893 |
| 140 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.93651503 |
| 141 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.93400095 |
| 142 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 0.93365781 |
| 143 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.93307272 |
| 144 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.92928993 |
| 145 | SMAD1_18555785_Chip-Seq_ESCs_Mouse | 0.92607215 |
| 146 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.92411410 |
| 147 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.91628359 |
| 148 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.91335382 |
| 149 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.91172975 |
| 150 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.90660479 |
| 151 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.90628272 |
| 152 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.90590792 |
| 153 | CTCF_18555785_Chip-Seq_ESCs_Mouse | 0.90501561 |
| 154 | * AR_20517297_ChIP-Seq_VCAP_Human | 0.90151338 |
| 155 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.89148372 |
| 156 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.88611939 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005410_abnormal_fertilization | 8.55089333 |
| 2 | MP0003698_abnormal_male_reproductive | 3.46304450 |
| 3 | MP0001929_abnormal_gametogenesis | 3.08834726 |
| 4 | MP0008789_abnormal_olfactory_epithelium | 2.84593835 |
| 5 | MP0008877_abnormal_DNA_methylation | 2.75623499 |
| 6 | MP0003183_abnormal_peptide_metabolism | 2.65529711 |
| 7 | MP0005645_abnormal_hypothalamus_physiol | 2.51033673 |
| 8 | MP0005379_endocrine/exocrine_gland_phen | 2.39507568 |
| 9 | MP0001984_abnormal_olfaction | 2.35180748 |
| 10 | MP0001986_abnormal_taste_sensitivity | 2.31014841 |
| 11 | MP0005499_abnormal_olfactory_system | 2.24581811 |
| 12 | MP0005394_taste/olfaction_phenotype | 2.24581811 |
| 13 | MP0006276_abnormal_autonomic_nervous | 2.20871091 |
| 14 | MP0008875_abnormal_xenobiotic_pharmacok | 2.15737847 |
| 15 | MP0002163_abnormal_gland_morphology | 2.13579722 |
| 16 | MP0004133_heterotaxia | 2.12573915 |
| 17 | MP0009379_abnormal_foot_pigmentation | 2.09140112 |
| 18 | MP0006292_abnormal_olfactory_placode | 2.05907714 |
| 19 | MP0009046_muscle_twitch | 2.05738532 |
| 20 | MP0002653_abnormal_ependyma_morphology | 2.05243890 |
| 21 | MP0010030_abnormal_orbit_morphology | 2.00244461 |
| 22 | MP0005646_abnormal_pituitary_gland | 1.97804828 |
| 23 | MP0001905_abnormal_dopamine_level | 1.95922132 |
| 24 | MP0004270_analgesia | 1.92009384 |
| 25 | MP0002210_abnormal_sex_determination | 1.88496642 |
| 26 | MP0001529_abnormal_vocalization | 1.88385908 |
| 27 | MP0002102_abnormal_ear_morphology | 1.87746149 |
| 28 | MP0006072_abnormal_retinal_apoptosis | 1.79439547 |
| 29 | MP0002282_abnormal_trachea_morphology | 1.76325999 |
| 30 | MP0000013_abnormal_adipose_tissue | 1.76233658 |
| 31 | MP0002161_abnormal_fertility/fecundity | 1.74758643 |
| 32 | MP0004043_abnormal_pH_regulation | 1.74520283 |
| 33 | MP0002837_dystrophic_cardiac_calcinosis | 1.65825945 |
| 34 | MP0001293_anophthalmia | 1.63651339 |
| 35 | MP0005423_abnormal_somatic_nervous | 1.63483831 |
| 36 | MP0004142_abnormal_muscle_tone | 1.62238117 |
| 37 | MP0001145_abnormal_male_reproductive | 1.62235521 |
| 38 | MP0005551_abnormal_eye_electrophysiolog | 1.56985229 |
| 39 | MP0002734_abnormal_mechanical_nocicepti | 1.54450502 |
| 40 | MP0003880_abnormal_central_pattern | 1.53781866 |
| 41 | MP0002272_abnormal_nervous_system | 1.52895657 |
| 42 | MP0000778_abnormal_nervous_system | 1.52106734 |
| 43 | MP0002233_abnormal_nose_morphology | 1.51996980 |
| 44 | MP0006036_abnormal_mitochondrial_physio | 1.49497005 |
| 45 | MP0000653_abnormal_sex_gland | 1.46662297 |
| 46 | MP0002160_abnormal_reproductive_system | 1.44270644 |
| 47 | MP0002876_abnormal_thyroid_physiology | 1.43390420 |
| 48 | MP0000049_abnormal_middle_ear | 1.43289788 |
| 49 | MP0002234_abnormal_pharynx_morphology | 1.40587761 |
| 50 | MP0002277_abnormal_respiratory_mucosa | 1.40072129 |
| 51 | MP0003136_yellow_coat_color | 1.38718401 |
| 52 | MP0005171_absent_coat_pigmentation | 1.37656924 |
| 53 | MP0002638_abnormal_pupillary_reflex | 1.35859285 |
| 54 | MP0005253_abnormal_eye_physiology | 1.35525297 |
| 55 | MP0002064_seizures | 1.30696720 |
| 56 | MP0010386_abnormal_urinary_bladder | 1.29565160 |
| 57 | MP0001968_abnormal_touch/_nociception | 1.29171215 |
| 58 | MP0002928_abnormal_bile_duct | 1.25981427 |
| 59 | MP0003122_maternal_imprinting | 1.25401950 |
| 60 | MP0005408_hypopigmentation | 1.24388002 |
| 61 | MP0003878_abnormal_ear_physiology | 1.24091007 |
| 62 | MP0005377_hearing/vestibular/ear_phenot | 1.24091007 |
| 63 | MP0009745_abnormal_behavioral_response | 1.23302540 |
| 64 | MP0001765_abnormal_ion_homeostasis | 1.21907298 |
| 65 | MP0005636_abnormal_mineral_homeostasis | 1.21807058 |
| 66 | MP0002736_abnormal_nociception_after | 1.21418294 |
| 67 | MP0003937_abnormal_limbs/digits/tail_de | 1.20728930 |
| 68 | MP0003011_delayed_dark_adaptation | 1.20227251 |
| 69 | MP0002572_abnormal_emotion/affect_behav | 1.20181808 |
| 70 | MP0005623_abnormal_meninges_morphology | 1.20131118 |
| 71 | MP0005248_abnormal_Harderian_gland | 1.19475741 |
| 72 | MP0000631_abnormal_neuroendocrine_gland | 1.18497826 |
| 73 | MP0005187_abnormal_penis_morphology | 1.18253873 |
| 74 | MP0004885_abnormal_endolymph | 1.15892183 |
| 75 | MP0003938_abnormal_ear_development | 1.14628389 |
| 76 | MP0001324_abnormal_eye_pigmentation | 1.12337803 |
| 77 | MP0001440_abnormal_grooming_behavior | 1.11782015 |
| 78 | MP0003890_abnormal_embryonic-extraembry | 1.11074671 |
| 79 | MP0005391_vision/eye_phenotype | 1.09397721 |
| 80 | MP0002090_abnormal_vision | 1.08585046 |
| 81 | MP0002557_abnormal_social/conspecific_i | 1.07861080 |
| 82 | MP0005195_abnormal_posterior_eye | 1.07591431 |
| 83 | MP0003718_maternal_effect | 1.07396250 |
| 84 | MP0002735_abnormal_chemical_nociception | 1.07028066 |
| 85 | MP0005409_darkened_coat_color | 1.05696077 |
| 86 | MP0006035_abnormal_mitochondrial_morpho | 1.05252993 |
| 87 | MP0001970_abnormal_pain_threshold | 1.03034715 |
| 88 | MP0001502_abnormal_circadian_rhythm | 1.02905077 |
| 89 | MP0005174_abnormal_tail_pigmentation | 1.02699693 |
| 90 | MP0003635_abnormal_synaptic_transmissio | 1.02695436 |
| 91 | MP0003195_calcinosis | 1.01797021 |
| 92 | MP0002229_neurodegeneration | 1.01525856 |
| 93 | MP0001286_abnormal_eye_development | 1.00249639 |
| 94 | MP0002733_abnormal_thermal_nociception | 1.00173687 |
| 95 | MP0001944_abnormal_pancreas_morphology | 0.99795822 |
| 96 | MP0001486_abnormal_startle_reflex | 0.99535801 |
| 97 | MP0000647_abnormal_sebaceous_gland | 0.99029033 |
| 98 | MP0000015_abnormal_ear_pigmentation | 0.98020224 |
| 99 | MP0001299_abnormal_eye_distance/ | 0.97747430 |
| 100 | MP0002095_abnormal_skin_pigmentation | 0.97700691 |
| 101 | MP0009697_abnormal_copulation | 0.97339286 |
| 102 | MP0002822_catalepsy | 0.97184756 |
| 103 | MP0003646_muscle_fatigue | 0.97045776 |
| 104 | MP0001188_hyperpigmentation | 0.97004822 |
| 105 | MP0002067_abnormal_sensory_capabilities | 0.96835676 |
| 106 | MP0003121_genomic_imprinting | 0.95422169 |
| 107 | MP0008995_early_reproductive_senescence | 0.94588096 |
| 108 | MP0005389_reproductive_system_phenotype | 0.93967969 |
| 109 | MP0001764_abnormal_homeostasis | 0.93947921 |
| 110 | MP0004019_abnormal_vitamin_homeostasis | 0.92600420 |
| 111 | MP0003755_abnormal_palate_morphology | 0.92572510 |
| 112 | MP0002751_abnormal_autonomic_nervous | 0.90946226 |
| 113 | MP0001346_abnormal_lacrimal_gland | 0.90942654 |
| 114 | MP0002693_abnormal_pancreas_physiology | 0.90852561 |
| 115 | MP0001963_abnormal_hearing_physiology | 0.88706346 |
| 116 | MP0003186_abnormal_redox_activity | 0.87696730 |
| 117 | MP0002184_abnormal_innervation | 0.86723088 |
| 118 | MP0004147_increased_porphyrin_level | 0.86053982 |
| 119 | MP0003329_amyloid_beta_deposits | 0.86006367 |
| 120 | MP0003806_abnormal_nucleotide_metabolis | 0.85253781 |
| 121 | MP0002752_abnormal_somatic_nervous | 0.84554953 |
| 122 | MP0000678_abnormal_parathyroid_gland | 0.84330355 |
| 123 | MP0008058_abnormal_DNA_repair | 0.83735536 |
| 124 | MP0001501_abnormal_sleep_pattern | 0.83381920 |
| 125 | MP0003942_abnormal_urinary_system | 0.82750745 |
| 126 | MP0008932_abnormal_embryonic_tissue | 0.81361828 |
| 127 | MP0005084_abnormal_gallbladder_morpholo | 0.81175441 |
| 128 | MP0004742_abnormal_vestibular_system | 0.79384002 |
| 129 | MP0001664_abnormal_digestion | 0.79360141 |
| 130 | MP0002909_abnormal_adrenal_gland | 0.77529624 |
| 131 | MP0000026_abnormal_inner_ear | 0.76892223 |
| 132 | MP0002882_abnormal_neuron_morphology | 0.75974147 |
| 133 | MP0003634_abnormal_glial_cell | 0.75756083 |
| 134 | MP0002132_abnormal_respiratory_system | 0.75481406 |
| 135 | MP0002063_abnormal_learning/memory/cond | 0.75403362 |
| 136 | MP0002938_white_spotting | 0.75078085 |
| 137 | MP0000566_synostosis | 0.74253552 |
| 138 | MP0000372_irregular_coat_pigmentation | 0.72859112 |
| 139 | MP0003786_premature_aging | 0.70933777 |
| 140 | MP0003879_abnormal_hair_cell | 0.70906985 |
| 141 | MP0004233_abnormal_muscle_weight | 0.68910332 |
| 142 | MP0000955_abnormal_spinal_cord | 0.68740699 |
| 143 | MP0001485_abnormal_pinna_reflex | 0.68501735 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 8.90310744 |
| 2 | Absent/shortened dynein arms (HP:0200106) | 7.93820015 |
| 3 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 7.93820015 |
| 4 | Abnormal respiratory motile cilium physiology (HP:0012261) | 7.13141878 |
| 5 | Abnormal respiratory epithelium morphology (HP:0012253) | 6.76323969 |
| 6 | Abnormal respiratory motile cilium morphology (HP:0005938) | 6.76323969 |
| 7 | Abnormal ciliary motility (HP:0012262) | 6.53632050 |
| 8 | Rhinitis (HP:0012384) | 5.82683839 |
| 9 | Chronic bronchitis (HP:0004469) | 4.93187024 |
| 10 | Acute necrotizing encephalopathy (HP:0006965) | 4.00798816 |
| 11 | Medial flaring of the eyebrow (HP:0010747) | 3.94394784 |
| 12 | Infertility (HP:0000789) | 3.80254382 |
| 13 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.79688213 |
| 14 | Mitochondrial inheritance (HP:0001427) | 3.52576854 |
| 15 | Progressive macrocephaly (HP:0004481) | 3.35335752 |
| 16 | Nephronophthisis (HP:0000090) | 3.30275655 |
| 17 | Acute encephalopathy (HP:0006846) | 3.27913676 |
| 18 | Bronchiectasis (HP:0002110) | 3.24574527 |
| 19 | Molar tooth sign on MRI (HP:0002419) | 3.22086172 |
| 20 | Abnormality of midbrain morphology (HP:0002418) | 3.22086172 |
| 21 | Congenital primary aphakia (HP:0007707) | 3.19098338 |
| 22 | Gait imbalance (HP:0002141) | 3.18617290 |
| 23 | Cystic liver disease (HP:0006706) | 3.12818765 |
| 24 | Tubulointerstitial nephritis (HP:0001970) | 3.02313532 |
| 25 | Nephrogenic diabetes insipidus (HP:0009806) | 2.98894045 |
| 26 | Nasal polyposis (HP:0100582) | 2.94938114 |
| 27 | Abnormality of renal resorption (HP:0011038) | 2.94613900 |
| 28 | Hepatocellular necrosis (HP:0001404) | 2.92868222 |
| 29 | Increased CSF lactate (HP:0002490) | 2.91080747 |
| 30 | Pancreatic fibrosis (HP:0100732) | 2.89529787 |
| 31 | Bronchitis (HP:0012387) | 2.87384442 |
| 32 | Chronic hepatic failure (HP:0100626) | 2.85431001 |
| 33 | True hermaphroditism (HP:0010459) | 2.78205931 |
| 34 | Sclerocornea (HP:0000647) | 2.74180694 |
| 35 | Increased hepatocellular lipid droplets (HP:0006565) | 2.67204835 |
| 36 | Renal Fanconi syndrome (HP:0001994) | 2.66926665 |
| 37 | Hypothermia (HP:0002045) | 2.66573188 |
| 38 | Anencephaly (HP:0002323) | 2.65952624 |
| 39 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.57735962 |
| 40 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.57735962 |
| 41 | Hepatic necrosis (HP:0002605) | 2.53981817 |
| 42 | Abnormality of the renal medulla (HP:0100957) | 2.49249046 |
| 43 | Lipid accumulation in hepatocytes (HP:0006561) | 2.48503115 |
| 44 | Median cleft lip (HP:0000161) | 2.44822808 |
| 45 | Genital tract atresia (HP:0001827) | 2.41343221 |
| 46 | Vaginal atresia (HP:0000148) | 2.38943344 |
| 47 | Retinal dysplasia (HP:0007973) | 2.38335146 |
| 48 | Optic disc pallor (HP:0000543) | 2.30718809 |
| 49 | Male pseudohermaphroditism (HP:0000037) | 2.30186794 |
| 50 | Abnormality of the nasal mucosa (HP:0000433) | 2.22850233 |
| 51 | Aplasia/Hypoplasia of the lens (HP:0008063) | 2.19629629 |
| 52 | Preaxial hand polydactyly (HP:0001177) | 2.19159996 |
| 53 | Poor coordination (HP:0002370) | 2.18251235 |
| 54 | Pancreatic cysts (HP:0001737) | 2.16760903 |
| 55 | Increased intramyocellular lipid droplets (HP:0012240) | 2.16149617 |
| 56 | Exercise intolerance (HP:0003546) | 2.15716551 |
| 57 | Type II lissencephaly (HP:0007260) | 2.15621215 |
| 58 | Decreased central vision (HP:0007663) | 2.07540532 |
| 59 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.07176879 |
| 60 | Leukodystrophy (HP:0002415) | 2.06184966 |
| 61 | Recurrent sinusitis (HP:0011108) | 2.04975952 |
| 62 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.03694044 |
| 63 | Furrowed tongue (HP:0000221) | 2.03337234 |
| 64 | Chronic sinusitis (HP:0011109) | 2.01783314 |
| 65 | Oculomotor apraxia (HP:0000657) | 2.00907481 |
| 66 | Tubular atrophy (HP:0000092) | 1.99629458 |
| 67 | Cerebral edema (HP:0002181) | 1.99312674 |
| 68 | Lactic acidosis (HP:0003128) | 1.97382955 |
| 69 | Taurodontia (HP:0000679) | 1.97004122 |
| 70 | Abnormality of permanent molar morphology (HP:0011071) | 1.97004122 |
| 71 | Abnormality of the dental root (HP:0006486) | 1.97004122 |
| 72 | Neuroendocrine neoplasm (HP:0100634) | 1.92863797 |
| 73 | Abnormal spermatogenesis (HP:0008669) | 1.92471329 |
| 74 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.91942032 |
| 75 | Supernumerary spleens (HP:0009799) | 1.90521683 |
| 76 | Abnormality of the dental pulp (HP:0006479) | 1.89176341 |
| 77 | Increased muscle lipid content (HP:0009058) | 1.87564166 |
| 78 | Tubulointerstitial abnormality (HP:0001969) | 1.86860408 |
| 79 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.86132051 |
| 80 | Postaxial hand polydactyly (HP:0001162) | 1.85597081 |
| 81 | Congenital hepatic fibrosis (HP:0002612) | 1.84727746 |
| 82 | Attenuation of retinal blood vessels (HP:0007843) | 1.83043006 |
| 83 | Postaxial foot polydactyly (HP:0001830) | 1.81685448 |
| 84 | Abnormality of molar morphology (HP:0011070) | 1.81584846 |
| 85 | Abnormality of molar (HP:0011077) | 1.81584846 |
| 86 | Recurrent otitis media (HP:0000403) | 1.80192342 |
| 87 | Respiratory failure (HP:0002878) | 1.79706736 |
| 88 | Hypoplasia of the uterus (HP:0000013) | 1.79647374 |
| 89 | Pheochromocytoma (HP:0002666) | 1.79267405 |
| 90 | Cerebellar dysplasia (HP:0007033) | 1.79047421 |
| 91 | Aganglionic megacolon (HP:0002251) | 1.78659060 |
| 92 | Increased serum lactate (HP:0002151) | 1.76876483 |
| 93 | Hyperglycinemia (HP:0002154) | 1.75386335 |
| 94 | 3-Methylglutaconic aciduria (HP:0003535) | 1.74816390 |
| 95 | Abnormality of urine glucose concentration (HP:0011016) | 1.74682700 |
| 96 | Glycosuria (HP:0003076) | 1.74682700 |
| 97 | Exertional dyspnea (HP:0002875) | 1.73999394 |
| 98 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.73537526 |
| 99 | Occipital encephalocele (HP:0002085) | 1.73481061 |
| 100 | Abnormality of the renal cortex (HP:0011035) | 1.72965072 |
| 101 | Methylmalonic aciduria (HP:0012120) | 1.71829424 |
| 102 | Polydipsia (HP:0001959) | 1.71239244 |
| 103 | Abnormal drinking behavior (HP:0030082) | 1.71239244 |
| 104 | Broad foot (HP:0001769) | 1.71185448 |
| 105 | Bile duct proliferation (HP:0001408) | 1.70938875 |
| 106 | Abnormal biliary tract physiology (HP:0012439) | 1.70938875 |
| 107 | Abnormality of renal excretion (HP:0011036) | 1.69990617 |
| 108 | Facial cleft (HP:0002006) | 1.69921852 |
| 109 | Retinitis pigmentosa (HP:0000510) | 1.69417985 |
| 110 | Poor suck (HP:0002033) | 1.67990028 |
| 111 | J-shaped sella turcica (HP:0002680) | 1.65904972 |
| 112 | Anophthalmia (HP:0000528) | 1.64477890 |
| 113 | Myokymia (HP:0002411) | 1.63594915 |
| 114 | Male infertility (HP:0003251) | 1.63066874 |
| 115 | Stage 5 chronic kidney disease (HP:0003774) | 1.62910921 |
| 116 | Bifid tongue (HP:0010297) | 1.61717320 |
| 117 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.61390336 |
| 118 | Narrow forehead (HP:0000341) | 1.60503929 |
| 119 | Septo-optic dysplasia (HP:0100842) | 1.60387503 |
| 120 | Short tibia (HP:0005736) | 1.60099603 |
| 121 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.58225348 |
| 122 | Decreased testicular size (HP:0008734) | 1.57289615 |
| 123 | Specific learning disability (HP:0001328) | 1.55968558 |
| 124 | Concave nail (HP:0001598) | 1.53616698 |
| 125 | Abnormality of the labia minora (HP:0012880) | 1.53066777 |
| 126 | Degeneration of anterior horn cells (HP:0002398) | 1.52000738 |
| 127 | Abnormality of the anterior horn cell (HP:0006802) | 1.52000738 |
| 128 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.51930329 |
| 129 | Multicystic kidney dysplasia (HP:0000003) | 1.51891184 |
| 130 | Holoprosencephaly (HP:0001360) | 1.48739961 |
| 131 | Prominent nasal bridge (HP:0000426) | 1.48274563 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PDK3 | 6.60698417 |
| 2 | PDK4 | 6.60698417 |
| 3 | PDK2 | 4.12095230 |
| 4 | STK16 | 2.99343126 |
| 5 | MAPK15 | 2.76789997 |
| 6 | TESK1 | 2.54114687 |
| 7 | WNK4 | 2.51571126 |
| 8 | STK39 | 2.50471451 |
| 9 | MUSK | 2.26863151 |
| 10 | MAP2K7 | 2.18386886 |
| 11 | MAP4K2 | 2.10678614 |
| 12 | WNK3 | 2.10373021 |
| 13 | VRK2 | 1.92179801 |
| 14 | PRKD3 | 1.87515835 |
| 15 | ERBB3 | 1.86096956 |
| 16 | TNIK | 1.83081968 |
| 17 | TRIM28 | 1.80529281 |
| 18 | GRK7 | 1.68955872 |
| 19 | CASK | 1.66961977 |
| 20 | IRAK1 | 1.64858929 |
| 21 | ARAF | 1.46386794 |
| 22 | OXSR1 | 1.45850368 |
| 23 | CSNK1G2 | 1.41699707 |
| 24 | ADRBK2 | 1.41180745 |
| 25 | ZAK | 1.40913857 |
| 26 | MAP3K12 | 1.40034998 |
| 27 | NEK1 | 1.37402996 |
| 28 | TLK1 | 1.36500662 |
| 29 | TTK | 1.35063773 |
| 30 | EPHB2 | 1.34071539 |
| 31 | NME1 | 1.33963336 |
| 32 | CDK19 | 1.26140934 |
| 33 | PNCK | 1.24131338 |
| 34 | IRAK2 | 1.23120224 |
| 35 | PLK2 | 1.22968140 |
| 36 | PLK3 | 1.17568134 |
| 37 | NTRK3 | 1.16483099 |
| 38 | EPHA4 | 1.14854297 |
| 39 | CCNB1 | 1.10779613 |
| 40 | PIM2 | 1.09934699 |
| 41 | NUAK1 | 1.09776363 |
| 42 | LMTK2 | 1.07084486 |
| 43 | FRK | 1.04494670 |
| 44 | DYRK3 | 1.04324288 |
| 45 | PLK1 | 1.04230170 |
| 46 | BMPR1B | 1.03386054 |
| 47 | MYLK | 1.02915488 |
| 48 | CSNK1G1 | 0.99206140 |
| 49 | YES1 | 0.99062713 |
| 50 | PIK3CG | 0.98311018 |
| 51 | PASK | 0.98233462 |
| 52 | BRAF | 0.97452335 |
| 53 | WEE1 | 0.96311106 |
| 54 | PTK2B | 0.96207118 |
| 55 | CSNK1A1L | 0.89593676 |
| 56 | CAMK2D | 0.86579155 |
| 57 | MKNK2 | 0.81550949 |
| 58 | EPHA2 | 0.79447975 |
| 59 | MKNK1 | 0.79132829 |
| 60 | MAP2K4 | 0.78208252 |
| 61 | BCR | 0.77688949 |
| 62 | MAPKAPK5 | 0.76518650 |
| 63 | VRK1 | 0.76241687 |
| 64 | DYRK2 | 0.75096281 |
| 65 | CDC7 | 0.74795028 |
| 66 | NTRK2 | 0.74224038 |
| 67 | BUB1 | 0.72985630 |
| 68 | PAK3 | 0.72516274 |
| 69 | GRK5 | 0.72164754 |
| 70 | BCKDK | 0.71831359 |
| 71 | PBK | 0.70996059 |
| 72 | INSRR | 0.70178391 |
| 73 | BRSK2 | 0.69919363 |
| 74 | UHMK1 | 0.67808140 |
| 75 | MAPK13 | 0.67528099 |
| 76 | STK24 | 0.67259240 |
| 77 | RPS6KA4 | 0.64141296 |
| 78 | EIF2AK3 | 0.62861619 |
| 79 | CAMK2B | 0.61611174 |
| 80 | MAP3K4 | 0.59943699 |
| 81 | PRKCG | 0.59805308 |
| 82 | EIF2AK1 | 0.59702644 |
| 83 | NEK6 | 0.58808193 |
| 84 | PHKG2 | 0.58618647 |
| 85 | PHKG1 | 0.58618647 |
| 86 | PINK1 | 0.58040614 |
| 87 | WNK1 | 0.56115197 |
| 88 | NME2 | 0.55944827 |
| 89 | CAMK2A | 0.55742850 |
| 90 | CAMK2G | 0.55687844 |
| 91 | EPHA3 | 0.54731758 |
| 92 | BMPR2 | 0.54338038 |
| 93 | ADRBK1 | 0.53572276 |
| 94 | SRPK1 | 0.52343826 |
| 95 | AURKB | 0.51162329 |
| 96 | MAP2K6 | 0.50433144 |
| 97 | TGFBR1 | 0.49846363 |
| 98 | MARK1 | 0.49625063 |
| 99 | CHEK2 | 0.49465165 |
| 100 | LRRK2 | 0.49297695 |
| 101 | MST4 | 0.47332205 |
| 102 | AURKA | 0.46075561 |
| 103 | CSNK1G3 | 0.44808060 |
| 104 | MINK1 | 0.44486521 |
| 105 | PDK1 | 0.44251356 |
| 106 | PKN1 | 0.43386970 |
| 107 | RIPK4 | 0.42696906 |
| 108 | CAMKK2 | 0.42672941 |
| 109 | LIMK1 | 0.40848026 |
| 110 | CSNK1A1 | 0.40803434 |
| 111 | ACVR1B | 0.39374894 |
| 112 | MAPKAPK3 | 0.39356575 |
| 113 | PLK4 | 0.38661385 |
| 114 | PRKCE | 0.38278248 |
| 115 | RPS6KA5 | 0.37887186 |
| 116 | PRKACA | 0.37688481 |
| 117 | SGK494 | 0.37318338 |
| 118 | SGK223 | 0.37318338 |
| 119 | DYRK1B | 0.37183474 |
| 120 | GRK1 | 0.36899473 |
| 121 | ICK | 0.36731854 |
| 122 | AKT3 | 0.35645016 |
| 123 | CSNK2A1 | 0.33096175 |
| 124 | ABL2 | 0.32425985 |
| 125 | SIK3 | 0.32283558 |
| 126 | CSNK2A2 | 0.32099169 |
| 127 | PRKCI | 0.31042682 |
| 128 | TSSK6 | 0.30677033 |
| 129 | PRKG2 | 0.27262619 |
| 130 | STK38L | 0.26517888 |
| 131 | OBSCN | 0.26364725 |
| 132 | CDK3 | 0.25362553 |
| 133 | BRSK1 | 0.24682431 |
| 134 | NTRK1 | 0.23879053 |
| 135 | PRKG1 | 0.23576920 |
| 136 | CDK8 | 0.22417532 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.72448999 |
| 2 | Parkinsons disease_Homo sapiens_hsa05012 | 3.80776716 |
| 3 | Protein export_Homo sapiens_hsa03060 | 3.77691322 |
| 4 | Huntingtons disease_Homo sapiens_hsa05016 | 3.41552548 |
| 5 | Alzheimers disease_Homo sapiens_hsa05010 | 2.85343352 |
| 6 | Proteasome_Homo sapiens_hsa03050 | 2.65155460 |
| 7 | Ribosome_Homo sapiens_hsa03010 | 2.51519828 |
| 8 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.31728313 |
| 9 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.22581499 |
| 10 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.20576818 |
| 11 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.16988075 |
| 12 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.06269580 |
| 13 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.04572437 |
| 14 | Basal transcription factors_Homo sapiens_hsa03022 | 1.97641329 |
| 15 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.81072019 |
| 16 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.63774683 |
| 17 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.62143351 |
| 18 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.59686615 |
| 19 | Phototransduction_Homo sapiens_hsa04744 | 1.57687657 |
| 20 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.56602145 |
| 21 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.54032495 |
| 22 | RNA polymerase_Homo sapiens_hsa03020 | 1.53038580 |
| 23 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.51339266 |
| 24 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.38088014 |
| 25 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.36830100 |
| 26 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.35793786 |
| 27 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.34567167 |
| 28 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.31883306 |
| 29 | Purine metabolism_Homo sapiens_hsa00230 | 1.31880100 |
| 30 | Mismatch repair_Homo sapiens_hsa03430 | 1.28679791 |
| 31 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.28355834 |
| 32 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.21932567 |
| 33 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.20879037 |
| 34 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.15703276 |
| 35 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.11473572 |
| 36 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.11009628 |
| 37 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.09894565 |
| 38 | Insulin secretion_Homo sapiens_hsa04911 | 1.08878184 |
| 39 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.08825894 |
| 40 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.05819141 |
| 41 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.05585892 |
| 42 | Spliceosome_Homo sapiens_hsa03040 | 1.05293071 |
| 43 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.05101136 |
| 44 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.04904572 |
| 45 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.02820951 |
| 46 | Taste transduction_Homo sapiens_hsa04742 | 1.02632409 |
| 47 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.01501687 |
| 48 | Metabolic pathways_Homo sapiens_hsa01100 | 1.00771962 |
| 49 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.99377802 |
| 50 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.96258839 |
| 51 | Retinol metabolism_Homo sapiens_hsa00830 | 0.94447089 |
| 52 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.94114091 |
| 53 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.88719669 |
| 54 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.83622730 |
| 55 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.81488706 |
| 56 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.81354161 |
| 57 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.80604168 |
| 58 | Olfactory transduction_Homo sapiens_hsa04740 | 0.80299534 |
| 59 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.78577028 |
| 60 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.76244606 |
| 61 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.74571512 |
| 62 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.74530162 |
| 63 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.74505733 |
| 64 | Base excision repair_Homo sapiens_hsa03410 | 0.74142707 |
| 65 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.74007018 |
| 66 | Nicotine addiction_Homo sapiens_hsa05033 | 0.73337999 |
| 67 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.72672605 |
| 68 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.72620179 |
| 69 | Carbon metabolism_Homo sapiens_hsa01200 | 0.72159044 |
| 70 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.71335644 |
| 71 | Homologous recombination_Homo sapiens_hsa03440 | 0.71328136 |
| 72 | RNA transport_Homo sapiens_hsa03013 | 0.69626357 |
| 73 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.69191656 |
| 74 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.68810732 |
| 75 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.68279869 |
| 76 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.67089109 |
| 77 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.65349944 |
| 78 | Cocaine addiction_Homo sapiens_hsa05030 | 0.64289310 |
| 79 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.63917943 |
| 80 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.63821603 |
| 81 | Sulfur relay system_Homo sapiens_hsa04122 | 0.62918559 |
| 82 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.62715896 |
| 83 | GABAergic synapse_Homo sapiens_hsa04727 | 0.61730605 |
| 84 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.58085163 |
| 85 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.57509816 |
| 86 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.56689237 |
| 87 | RNA degradation_Homo sapiens_hsa03018 | 0.56554239 |
| 88 | Circadian entrainment_Homo sapiens_hsa04713 | 0.56546461 |
| 89 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.55966531 |
| 90 | Peroxisome_Homo sapiens_hsa04146 | 0.55376204 |
| 91 | DNA replication_Homo sapiens_hsa03030 | 0.54693182 |
| 92 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.54498737 |
| 93 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.54405878 |
| 94 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.53269890 |
| 95 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.52410695 |
| 96 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.52312222 |
| 97 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.52006467 |
| 98 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.50228994 |
| 99 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.49368704 |
| 100 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.49150867 |
| 101 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.48684788 |
| 102 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.48599172 |
| 103 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.48205021 |
| 104 | Morphine addiction_Homo sapiens_hsa05032 | 0.48144894 |
| 105 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.48034417 |
| 106 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.47946712 |
| 107 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.47860024 |
| 108 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.46575869 |
| 109 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.45221345 |
| 110 | Histidine metabolism_Homo sapiens_hsa00340 | 0.44835668 |
| 111 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.43373985 |
| 112 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.42997598 |
| 113 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.42757588 |
| 114 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.42459025 |
| 115 | Other glycan degradation_Homo sapiens_hsa00511 | 0.42034235 |
| 116 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.41552369 |
| 117 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.40774162 |
| 118 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.40680412 |
| 119 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.40220154 |
| 120 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.39414394 |
| 121 | Renin secretion_Homo sapiens_hsa04924 | 0.38706471 |
| 122 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.38212449 |
| 123 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.37729749 |
| 124 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.37280000 |
| 125 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.37050861 |
| 126 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.36696309 |
| 127 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.36161047 |
| 128 | Alcoholism_Homo sapiens_hsa05034 | 0.35892020 |
| 129 | Cell cycle_Homo sapiens_hsa04110 | 0.35249627 |
| 130 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.30877271 |
| 131 | Axon guidance_Homo sapiens_hsa04360 | 0.28787527 |

