MOS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1female gamete generation (GO:0007292)8.63256182
2meiotic cell cycle (GO:0051321)7.56039489
3mitotic chromosome condensation (GO:0007076)7.38203840
4base-excision repair, AP site formation (GO:0006285)7.18507648
5attachment of spindle microtubules to kinetochore (GO:0008608)7.12588445
6regulation of steroid hormone secretion (GO:2000831)7.08502713
7piRNA metabolic process (GO:0034587)6.90285615
8negative regulation of meiosis (GO:0045835)6.90069871
9protein localization to kinetochore (GO:0034501)6.48491637
10pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.32691389
11mitotic metaphase plate congression (GO:0007080)6.09843589
12regulation of histone H3-K27 methylation (GO:0061085)5.91621969
13protein K6-linked ubiquitination (GO:0085020)5.87029237
14protein localization to chromosome, centromeric region (GO:0071459)5.56983922
15pyrimidine nucleotide catabolic process (GO:0006244)5.32666702
16histone H2A monoubiquitination (GO:0035518)5.29578299
17* regulation of meiosis (GO:0040020)5.21044739
18histone H2A ubiquitination (GO:0033522)5.13701939
19metaphase plate congression (GO:0051310)5.03784808
20negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.81998298
21negative regulation of DNA-templated transcription, elongation (GO:0032785)4.81998298
22protein localization to chromosome (GO:0034502)4.59931781
23chromatin assembly (GO:0031497)4.55875684
24oocyte maturation (GO:0001556)4.48976319
25establishment of chromosome localization (GO:0051303)4.43486587
26endothelium development (GO:0003158)4.43057831
27regulation of mitotic spindle organization (GO:0060236)4.38712547
28chromatin assembly or disassembly (GO:0006333)4.32064288
29* negative regulation of meiotic cell cycle (GO:0051447)4.26455969
30CENP-A containing nucleosome assembly (GO:0034080)4.26232505
31negative regulation of smooth muscle cell differentiation (GO:0051151)4.10870114
32chromatin remodeling at centromere (GO:0031055)4.08405371
33folic acid-containing compound biosynthetic process (GO:0009396)4.07515034
34notochord development (GO:0030903)4.06488276
35* regulation of meiotic cell cycle (GO:0051445)4.05639022
36negative regulation of histone methylation (GO:0031061)4.00586331
37regulation of sister chromatid cohesion (GO:0007063)3.98856354
38chaperone-mediated protein transport (GO:0072321)3.98451051
39regulation of autophagic vacuole assembly (GO:2000785)3.97801766
40histone exchange (GO:0043486)3.91316217
41positive regulation of chromosome segregation (GO:0051984)3.90119481
42response to pheromone (GO:0019236)3.83732408
43regulation of spindle organization (GO:0090224)3.83423936
44DNA damage induced protein phosphorylation (GO:0006975)3.81325890
45regulation of acrosome reaction (GO:0060046)3.79635708
46negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.77455484
47mitotic sister chromatid segregation (GO:0000070)3.76968182
48one-carbon metabolic process (GO:0006730)3.73079086
49DNA methylation involved in gamete generation (GO:0043046)3.71866531
50negative regulation of reproductive process (GO:2000242)3.71585751
51DNA replication-independent nucleosome assembly (GO:0006336)3.62295133
52DNA replication-independent nucleosome organization (GO:0034724)3.62295133
53maturation of 5.8S rRNA (GO:0000460)3.61811001
54positive regulation of Cdc42 GTPase activity (GO:0043089)3.56662602
55regulation of exit from mitosis (GO:0007096)3.48922208
56membrane tubulation (GO:0097320)3.44567597
57positive regulation of mitotic sister chromatid separation (GO:1901970)3.44384513
58positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.44384513
59positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.44384513
60regulation of reproductive process (GO:2000241)3.43599414
61pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.38526122
62gene silencing by RNA (GO:0031047)3.37759522
63regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.35936604
64male meiosis (GO:0007140)3.32521651
65microtubule severing (GO:0051013)3.31816128
66multicellular organism reproduction (GO:0032504)3.30009696
67spindle checkpoint (GO:0031577)3.26978000
68regulation of hypersensitivity (GO:0002883)3.25127580
69chromosome segregation (GO:0007059)3.23160957
70mitotic nuclear envelope disassembly (GO:0007077)3.22807715
71positive regulation of T cell apoptotic process (GO:0070234)3.22463060
72muscle cell migration (GO:0014812)3.19605574
73negative regulation of execution phase of apoptosis (GO:1900118)3.18592517
74regulation of transforming growth factor beta2 production (GO:0032909)3.18446004
75glycerophospholipid catabolic process (GO:0046475)3.17897130
76S-adenosylmethionine metabolic process (GO:0046500)3.11624228
77regulation of endocrine process (GO:0044060)3.10202923
78regulation of RIG-I signaling pathway (GO:0039535)3.09495606
79microtubule anchoring (GO:0034453)3.08874164
80nuclear envelope disassembly (GO:0051081)3.08147832
81membrane disassembly (GO:0030397)3.08147832
82negative regulation of nuclear division (GO:0051784)3.07202298
83cytoskeleton-dependent cytokinesis (GO:0061640)3.05840730
84cytoplasmic mRNA processing body assembly (GO:0033962)3.05064938
85positive regulation of cytokinesis (GO:0032467)3.05042643
86microtubule nucleation (GO:0007020)3.03675576
87sister chromatid segregation (GO:0000819)3.02661784
88ventricular cardiac muscle cell development (GO:0055015)3.00369980
89regulation of retinoic acid receptor signaling pathway (GO:0048385)2.96848868
90regulation of chromosome segregation (GO:0051983)2.93988313
91regulation of phospholipid biosynthetic process (GO:0071071)2.93709760
92oocyte development (GO:0048599)2.93309638
93mitotic spindle checkpoint (GO:0071174)2.92008673
94regulation of vacuole organization (GO:0044088)2.91739632
95chromosome condensation (GO:0030261)2.90209125
96DNA replication checkpoint (GO:0000076)2.87489616
97negative regulation of cell division (GO:0051782)2.86719204
98negative regulation of chromosome segregation (GO:0051985)2.86254062
99regulation of female gonad development (GO:2000194)14.4761246
100regulation of DNA methylation (GO:0044030)10.1845677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.35542229
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.83483973
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.01258014
4AR_21909140_ChIP-Seq_LNCAP_Human3.83928764
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.09905724
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.96858734
7E2F7_22180533_ChIP-Seq_HELA_Human2.88447714
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.52151210
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.50808854
10RUNX1_26923725_Chip-Seq_HPCs_Mouse2.46520056
11MYC_18940864_ChIP-ChIP_HL60_Human2.46232601
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.42559280
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.39780300
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33730815
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11406818
16MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.11322675
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99331357
18GATA1_26923725_Chip-Seq_HPCs_Mouse1.96486197
19* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.94023261
20ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.91384034
21FOXM1_26456572_ChIP-Seq_MCF-7_Human1.55965268
22TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53801547
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.44615465
24EZH2_22144423_ChIP-Seq_EOC_Human1.43796661
25ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37863408
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.37202597
27SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.36977893
28CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35079715
29VDR_22108803_ChIP-Seq_LS180_Human1.32496702
30TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31438479
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31004411
32CDX2_22108803_ChIP-Seq_LS180_Human1.28955907
33OCT1_27270436_Chip-Seq_PROSTATE_Human1.25348547
34CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25109715
35NANOG_21062744_ChIP-ChIP_HESCs_Human1.24936684
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24511017
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23249094
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.23169968
39GF1B_26923725_Chip-Seq_HPCs_Mouse1.20114388
40EWS_26573619_Chip-Seq_HEK293_Human1.18637482
41PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.17039120
42FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16818491
43NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16245351
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15311625
45MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.14825650
46AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14295849
47NFYA_21822215_ChIP-Seq_K562_Human1.10843002
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09778662
49BCAT_22108803_ChIP-Seq_LS180_Human1.08704291
50TP63_23658742_ChIP-Seq_EP156T_Human1.08161987
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07982015
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07413553
53SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07381967
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05406780
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03387698
56STAT3_23295773_ChIP-Seq_U87_Human1.02545107
57TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02492488
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02289309
59SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99790134
60NANOG_20526341_ChIP-Seq_ESCs_Human0.99108135
61FUS_26573619_Chip-Seq_HEK293_Human0.98577541
62* SMRT_27268052_Chip-Seq_Bcells_Human0.98391656
63LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98262757
64SMAD4_21741376_ChIP-Seq_EPCs_Human0.97725265
65FOXH1_21741376_ChIP-Seq_EPCs_Human0.95499088
66TBX20_22080862_ChIP-Seq_HEART_Mouse0.94835512
67TBX20_22328084_ChIP-Seq_HEART_Mouse0.94835512
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94408080
69CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94029622
70P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91927997
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91181792
72RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89395323
73ESR1_21235772_ChIP-Seq_MCF-7_Human0.88549248
74EP300_21415370_ChIP-Seq_HL-1_Mouse0.87917069
75STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87765968
76FLI1_27457419_Chip-Seq_LIVER_Mouse0.87435338
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87367674
78LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87118092
79PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86806225
80CEBPB_22108803_ChIP-Seq_LS180_Human0.86799578
81FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86424332
82FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86239757
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86076045
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86016492
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85204237
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85182836
87SMAD4_21799915_ChIP-Seq_A2780_Human0.85086108
88AR_21572438_ChIP-Seq_LNCaP_Human0.84057740
89AR_25329375_ChIP-Seq_VCAP_Human0.83401419
90* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.82077627
91TET1_21490601_ChIP-Seq_MESCs_Mouse0.81774271
92* RNF2_27304074_Chip-Seq_NSC_Mouse0.79675954
93* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79140607
94* GATA3_21867929_ChIP-Seq_TH1_Mouse0.79045711
95GF1_26923725_Chip-Seq_HPCs_Mouse0.78663012
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78492030
97ETV1_20927104_ChIP-Seq_GIST48_Human0.78179023
98CJUN_26792858_Chip-Seq_BT549_Human0.77293070
99TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.74118199
100PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.73266009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect8.16607350
2MP0005451_abnormal_body_composition6.91026060
3MP0002653_abnormal_ependyma_morphology4.56495175
4MP0003646_muscle_fatigue3.79995139
5MP0005395_other_phenotype3.69811876
6MP0010094_abnormal_chromosome_stability3.23708828
7* MP0003699_abnormal_female_reproductive3.04532211
8* MP0001119_abnormal_female_reproductive2.96626003
9MP0003111_abnormal_nucleus_morphology2.84236832
10MP0003693_abnormal_embryo_hatching2.82386309
11MP0004859_abnormal_synaptic_plasticity2.46291570
12MP0002295_abnormal_pulmonary_circulatio2.38077968
13MP0003077_abnormal_cell_cycle2.30577031
14MP0004264_abnormal_extraembryonic_tissu2.30028396
15MP0008877_abnormal_DNA_methylation2.27839080
16MP0001915_intracranial_hemorrhage2.26961670
17MP0003705_abnormal_hypodermis_morpholog2.26202446
18MP0002102_abnormal_ear_morphology2.18180729
19MP0006072_abnormal_retinal_apoptosis2.14804028
20MP0008260_abnormal_autophagy2.11902155
21* MP0000653_abnormal_sex_gland2.02220169
22* MP0001929_abnormal_gametogenesis2.02147528
23MP0004957_abnormal_blastocyst_morpholog1.93354344
24MP0009840_abnormal_foam_cell1.86887926
25MP0002210_abnormal_sex_determination1.81837276
26MP0006292_abnormal_olfactory_placode1.79750110
27MP0001905_abnormal_dopamine_level1.75480582
28MP0010234_abnormal_vibrissa_follicle1.64949895
29* MP0002161_abnormal_fertility/fecundity1.60212549
30MP0003950_abnormal_plasma_membrane1.56289943
31MP0001529_abnormal_vocalization1.53214385
32MP0008932_abnormal_embryonic_tissue1.48820474
33MP0005408_hypopigmentation1.46467159
34MP0002932_abnormal_joint_morphology1.44613017
35MP0000579_abnormal_nail_morphology1.29325092
36MP0004510_myositis1.25516055
37MP0005310_abnormal_salivary_gland1.25145777
38MP0001849_ear_inflammation1.21580668
39MP0003453_abnormal_keratinocyte_physiol1.20678372
40MP0001485_abnormal_pinna_reflex1.20456956
41MP0003937_abnormal_limbs/digits/tail_de1.18669191
42MP0000350_abnormal_cell_proliferation1.17888502
43MP0000465_gastrointestinal_hemorrhage1.13455127
44MP0004185_abnormal_adipocyte_glucose1.11728589
45MP0000427_abnormal_hair_cycle1.08411506
46MP0005197_abnormal_uvea_morphology1.07237963
47MP0002933_joint_inflammation0.96331902
48MP0010368_abnormal_lymphatic_system0.94261586
49MP0001145_abnormal_male_reproductive0.92305215
50MP0002085_abnormal_embryonic_tissue0.91678283
51MP0005023_abnormal_wound_healing0.90738697
52MP0005360_urolithiasis0.89162104
53MP0010386_abnormal_urinary_bladder0.88500858
54MP0003763_abnormal_thymus_physiology0.87625876
55MP0005647_abnormal_sex_gland0.86797794
56MP0001730_embryonic_growth_arrest0.85046675
57MP0008007_abnormal_cellular_replicative0.84073232
58MP0008875_abnormal_xenobiotic_pharmacok0.82009211
59MP0000639_abnormal_adrenal_gland0.81754892
60MP0003890_abnormal_embryonic-extraembry0.80045458
61MP0001697_abnormal_embryo_size0.79416451
62MP0002084_abnormal_developmental_patter0.77425800
63MP0005621_abnormal_cell_physiology0.76678535
64MP0003121_genomic_imprinting0.74892892
65MP0003315_abnormal_perineum_morphology0.74511616
66* MP0002019_abnormal_tumor_incidence0.71024829
67MP0002177_abnormal_outer_ear0.70809843
68MP0005257_abnormal_intraocular_pressure0.70445976
69MP0000490_abnormal_crypts_of0.70393342
70MP0001919_abnormal_reproductive_system0.69576708
71MP0010352_gastrointestinal_tract_polyps0.67244161
72MP0009384_cardiac_valve_regurgitation0.64979595
73MP0003075_altered_response_to0.63093408
74MP0005380_embryogenesis_phenotype0.61977460
75MP0001672_abnormal_embryogenesis/_devel0.61977460
76MP0001502_abnormal_circadian_rhythm0.61682466
77MP0010678_abnormal_skin_adnexa0.60869399
78MP0005166_decreased_susceptibility_to0.57115239
79MP0002168_other_aberrant_phenotype0.57090891
80MP0005187_abnormal_penis_morphology0.56565416
81MP0002736_abnormal_nociception_after0.54563942
82MP0000631_abnormal_neuroendocrine_gland0.53545656
83MP0009697_abnormal_copulation0.53300419
84MP0000477_abnormal_intestine_morphology0.52715021
85MP0002249_abnormal_larynx_morphology0.52673155
86MP0005670_abnormal_white_adipose0.51710961
87MP0003787_abnormal_imprinting0.50552423
88MP0000733_abnormal_muscle_development0.46836346
89MP0004484_altered_response_of0.46517398
90MP0003755_abnormal_palate_morphology0.44692619
91MP0002269_muscular_atrophy0.44590603
92MP0005384_cellular_phenotype0.44195877
93MP0004782_abnormal_surfactant_physiolog0.43547340
94MP0005389_reproductive_system_phenotype0.43415562
95MP0003861_abnormal_nervous_system0.42999550
96MP0009763_increased_sensitivity_to0.41755998
97MP0001346_abnormal_lacrimal_gland0.41331124
98MP0003698_abnormal_male_reproductive0.38070410
99MP0002080_prenatal_lethality0.37810057
100MP0001666_abnormal_nutrient_absorption0.36955804

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)8.37781399
2Cholecystitis (HP:0001082)6.33814129
3Abnormal gallbladder physiology (HP:0012438)6.33814129
4Birth length less than 3rd percentile (HP:0003561)5.48032036
5Infertility (HP:0000789)5.13689142
6Breast hypoplasia (HP:0003187)4.86564526
7Premature ovarian failure (HP:0008209)4.67053292
8Rhabdomyosarcoma (HP:0002859)4.40465905
9Aplasia/Hypoplasia of the sternum (HP:0006714)4.21433870
10Cortical dysplasia (HP:0002539)4.14585394
11Abnormality of the labia minora (HP:0012880)3.59844596
12Secondary amenorrhea (HP:0000869)3.49206095
13Short 1st metacarpal (HP:0010034)3.48986992
14Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.48986992
15Overlapping toe (HP:0001845)3.43491250
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.42081273
17Combined immunodeficiency (HP:0005387)3.40783439
18Neoplasm of striated muscle (HP:0009728)3.32204084
19Papillary thyroid carcinoma (HP:0002895)3.16631588
20Chromsome breakage (HP:0040012)3.06352725
21Abnormality of the 1st metacarpal (HP:0010009)3.00622035
22Abnormality of lateral ventricle (HP:0030047)2.96291776
23Hypergonadotropic hypogonadism (HP:0000815)2.92366895
24Arterial tortuosity (HP:0005116)2.82966437
25Patellar aplasia (HP:0006443)2.82658041
26Abnormal sex determination (HP:0012244)2.79650766
27Sex reversal (HP:0012245)2.79650766
28Chronic bronchitis (HP:0004469)2.76278896
29Short phalanx of the thumb (HP:0009660)2.71429797
30Atelectasis (HP:0100750)2.67589741
31Shawl scrotum (HP:0000049)2.67576731
32Diastasis recti (HP:0001540)2.61337060
33Abnormality of chromosome segregation (HP:0002916)2.58862564
34Adrenal hypoplasia (HP:0000835)2.58216699
35Abnormality of the proximal phalanges of the hand (HP:0009834)2.55870892
36Aplasia/Hypoplasia of the patella (HP:0006498)2.53169100
37Abnormality of cochlea (HP:0000375)2.51503488
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47313662
39Fibular aplasia (HP:0002990)2.44331516
40Vascular tortuosity (HP:0004948)2.43541144
41Sandal gap (HP:0001852)2.37724881
42Pulmonary fibrosis (HP:0002206)2.37694829
43Hyperalaninemia (HP:0003348)2.34582019
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34582019
45Abnormality of alanine metabolism (HP:0010916)2.34582019
46Chin dimple (HP:0010751)2.32277607
47Breast aplasia (HP:0100783)2.28479845
48Aplasia/Hypoplasia of the breasts (HP:0010311)2.27536756
49Uterine leiomyosarcoma (HP:0002891)2.23126177
50Leiomyosarcoma (HP:0100243)2.23126177
51Nephroblastoma (Wilms tumor) (HP:0002667)2.21461076
52Rib fusion (HP:0000902)2.20848546
53Flat capital femoral epiphysis (HP:0003370)2.19992032
54Hypoplastic iliac wings (HP:0002866)2.16658855
55Aplasia/Hypoplasia involving the musculature (HP:0001460)2.14821597
56Small intestinal stenosis (HP:0012848)2.13339906
57Duodenal stenosis (HP:0100867)2.13339906
58Fetal akinesia sequence (HP:0001989)2.12680142
59Insulin-resistant diabetes mellitus (HP:0000831)2.12578691
60Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.11124738
61Aplasia involving bones of the upper limbs (HP:0009823)2.10847089
62Aplasia of the phalanges of the hand (HP:0009802)2.10847089
63Aplasia involving bones of the extremities (HP:0009825)2.10847089
64Embryonal renal neoplasm (HP:0011794)2.03990598
65Abnormal lung lobation (HP:0002101)2.02959087
66Male infertility (HP:0003251)10.6829050
67Cholelithiasis (HP:0001081)1.99779856
68Abnormality of the intervertebral disk (HP:0005108)1.99656100
69Anomalous pulmonary venous return (HP:0010772)1.97425438
70Spondylolisthesis (HP:0003302)1.96979367
71Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.95363543
72Cerebral hypomyelination (HP:0006808)1.94781909
73Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.91538126
74Calcaneovalgus deformity (HP:0001848)1.90008189
75Stenosis of the external auditory canal (HP:0000402)1.88976814
76Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.88677693
77Abnormal gallbladder morphology (HP:0012437)1.88613943
78Abnormality of placental membranes (HP:0011409)1.88120117
79Amniotic constriction ring (HP:0009775)1.88120117
80Transitional cell carcinoma of the bladder (HP:0006740)1.86805167
81Abnormality of the fingertips (HP:0001211)1.82016508
82Primary amenorrhea (HP:0000786)1.80109043
83Metatarsus adductus (HP:0001840)1.79292117
84Short thumb (HP:0009778)1.77795625
85Capillary hemangiomas (HP:0005306)1.74627445
86Absent forearm bone (HP:0003953)1.74508013
87Aplasia involving forearm bones (HP:0009822)1.74508013
88Malignant gastrointestinal tract tumors (HP:0006749)1.73695728
89Gastrointestinal carcinoma (HP:0002672)1.73695728
90Abnormality of chromosome stability (HP:0003220)1.73681184
91Slender long bone (HP:0003100)1.72686398
92Facial hemangioma (HP:0000329)1.72269941
93Clitoromegaly (HP:0000057)1.70271024
94Occipital encephalocele (HP:0002085)1.70259353
95Bladder neoplasm (HP:0009725)1.68341946
96Bladder carcinoma (HP:0002862)1.68341946
97Abnormality of the clitoris (HP:0000056)1.67418024
98Absent radius (HP:0003974)1.67289615
99Abnormality of the duodenum (HP:0002246)1.66603018
100Medulloblastoma (HP:0002885)1.63475800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK38.44162733
2TTK3.67349292
3LATS13.60464307
4MAP3K63.51955180
5LATS23.35597988
6MAP3K93.11601591
7PLK42.85026124
8KSR22.78461782
9MAP3K132.67672870
10STK102.65736358
11CDC72.50357340
12STK38L2.35640305
13ARAF2.33710925
14TAOK12.16419117
15CDK82.09393878
16DYRK22.05233406
17CDK92.02985718
18MELK1.82516536
19BUB11.80572742
20NLK1.78628019
21CSNK1G11.67439666
22BRAF1.50448320
23RAF11.48430254
24PRKD31.43431342
25PLK11.33089841
26RET1.31263933
27CSNK1G31.25548492
28MAP3K81.24100500
29ERBB41.15941458
30PINK11.14588178
31CSNK1G21.13361913
32CSNK1A1L1.09809759
33PAK61.06715812
34* MOS1.05111668
35MAP3K41.02470577
36NEK20.96371595
37KSR10.93021257
38LRRK20.90768294
39TYRO30.89296019
40HIPK20.89174082
41NEK10.86137543
42STK30.83498638
43PRKD20.82037477
44CHEK20.81592792
45MAPK130.78747530
46PKN20.77815912
47STK380.73017021
48ABL20.70532532
49AURKA0.69496856
50AURKB0.67719204
51TRIB30.65817248
52CDK40.62860540
53SGK2230.56829078
54SGK4940.56829078
55EPHA40.53530642
56SGK20.52002060
57DMPK0.47619451
58PLK20.46267330
59PRKAA10.44865380
60EPHA30.44088892
61MUSK0.39070096
62MAP2K70.38795035
63MARK20.37315949
64ACVR1B0.34871300
65MAP3K10.33104552
66ROCK20.32790461
67KIT0.32080709
68CAMK2A0.30877192
69EEF2K0.28042281
70CSNK1D0.26377489
71PLK30.25670291
72MAP2K40.25242467
73ROCK10.25005152
74SGK10.24416840
75ABL10.24281778
76MAP2K10.23883975
77MAP3K70.23813930
78SGK30.21960393
79CDK10.21150985
80PAK10.19897582
81ATM0.17854150
82PRKAA20.17556762
83CDK70.17221450
84EIF2AK10.16864725
85PRKACB0.16104573
86CDK20.15672082
87JAK20.13706049
88ADRBK10.13327860
89MAPKAPK30.13034628
90CSNK1A10.12089133
91DYRK1A0.11168946
92RPS6KA30.10426555
93MAPK10.09837046
94PRKCI0.09415140
95PNCK0.07444168
96STK110.07084460
97AKT10.07046057
98CHEK10.06488743
99PRKCQ0.05906888
100ATR0.05208298

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049136.55900968
2Circadian rhythm_Homo sapiens_hsa047103.83647356
3RNA degradation_Homo sapiens_hsa030183.62984301
4Basal transcription factors_Homo sapiens_hsa030223.59126134
5Cell cycle_Homo sapiens_hsa041103.57539878
6* Oocyte meiosis_Homo sapiens_hsa041142.87437313
7Folate biosynthesis_Homo sapiens_hsa007902.35213835
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.16409517
9Linoleic acid metabolism_Homo sapiens_hsa005912.13317048
10Ether lipid metabolism_Homo sapiens_hsa005652.11225172
11Pancreatic cancer_Homo sapiens_hsa052122.11165517
12Dorso-ventral axis formation_Homo sapiens_hsa043202.06994542
13Cysteine and methionine metabolism_Homo sapiens_hsa002701.94441349
14Base excision repair_Homo sapiens_hsa034101.93888754
15Non-homologous end-joining_Homo sapiens_hsa034501.90594611
16TGF-beta signaling pathway_Homo sapiens_hsa043501.71194265
17GnRH signaling pathway_Homo sapiens_hsa049121.70918746
18MicroRNAs in cancer_Homo sapiens_hsa052061.70263771
19DNA replication_Homo sapiens_hsa030301.52038446
20* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.46399871
21mRNA surveillance pathway_Homo sapiens_hsa030151.44102038
22Fanconi anemia pathway_Homo sapiens_hsa034601.36059252
23Long-term depression_Homo sapiens_hsa047301.27947177
24Notch signaling pathway_Homo sapiens_hsa043301.11346585
25Colorectal cancer_Homo sapiens_hsa052101.03982889
26Vitamin B6 metabolism_Homo sapiens_hsa007501.03540141
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99197190
28Prolactin signaling pathway_Homo sapiens_hsa049170.98138028
29RNA transport_Homo sapiens_hsa030130.96796520
30Choline metabolism in cancer_Homo sapiens_hsa052310.94395997
31Homologous recombination_Homo sapiens_hsa034400.93255648
32p53 signaling pathway_Homo sapiens_hsa041150.90391187
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89439861
34Complement and coagulation cascades_Homo sapiens_hsa046100.88796859
35VEGF signaling pathway_Homo sapiens_hsa043700.87727107
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86788230
37Glycerophospholipid metabolism_Homo sapiens_hsa005640.84966332
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84224103
39Hippo signaling pathway_Homo sapiens_hsa043900.83128545
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81143003
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80343684
42Nucleotide excision repair_Homo sapiens_hsa034200.75801130
43Adherens junction_Homo sapiens_hsa045200.74826131
44Glutamatergic synapse_Homo sapiens_hsa047240.74807808
45FoxO signaling pathway_Homo sapiens_hsa040680.74389930
46Regulation of autophagy_Homo sapiens_hsa041400.73953255
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72792632
48RNA polymerase_Homo sapiens_hsa030200.72406957
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72208291
50Ras signaling pathway_Homo sapiens_hsa040140.68241729
51Thyroid cancer_Homo sapiens_hsa052160.66375135
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63514092
53Olfactory transduction_Homo sapiens_hsa047400.62914025
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61613279
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61430516
56Gap junction_Homo sapiens_hsa045400.60650846
57Estrogen signaling pathway_Homo sapiens_hsa049150.59190880
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58992634
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.57611752
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57154318
61Wnt signaling pathway_Homo sapiens_hsa043100.53352476
62Chronic myeloid leukemia_Homo sapiens_hsa052200.51880921
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49428886
64Glucagon signaling pathway_Homo sapiens_hsa049220.47712237
65Bladder cancer_Homo sapiens_hsa052190.44685188
66Serotonergic synapse_Homo sapiens_hsa047260.43618490
67Hedgehog signaling pathway_Homo sapiens_hsa043400.43273904
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42601457
69Oxytocin signaling pathway_Homo sapiens_hsa049210.42566523
70Long-term potentiation_Homo sapiens_hsa047200.41335029
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40363910
72HTLV-I infection_Homo sapiens_hsa051660.40189955
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38795096
74Arginine biosynthesis_Homo sapiens_hsa002200.38216656
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.37713005
76Renal cell carcinoma_Homo sapiens_hsa052110.37681964
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35915011
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34704109
79mTOR signaling pathway_Homo sapiens_hsa041500.33613843
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.33331752
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.32884456
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31735109
83Endometrial cancer_Homo sapiens_hsa052130.31227201
84Cholinergic synapse_Homo sapiens_hsa047250.31207888
85Gastric acid secretion_Homo sapiens_hsa049710.31060965
86Glioma_Homo sapiens_hsa052140.30707113
87Tight junction_Homo sapiens_hsa045300.30582565
88Bile secretion_Homo sapiens_hsa049760.30572659
89Small cell lung cancer_Homo sapiens_hsa052220.28529011
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27669500
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27605670
92Mismatch repair_Homo sapiens_hsa034300.26990905
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25106782
94ErbB signaling pathway_Homo sapiens_hsa040120.22833005
95Shigellosis_Homo sapiens_hsa051310.21221040
96Non-small cell lung cancer_Homo sapiens_hsa052230.21015673
97cAMP signaling pathway_Homo sapiens_hsa040240.20951618
98Propanoate metabolism_Homo sapiens_hsa006400.20872221
99Pancreatic secretion_Homo sapiens_hsa049720.18926276
100Arachidonic acid metabolism_Homo sapiens_hsa005900.18888824

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