MOSPD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.33647632
2sperm motility (GO:0030317)6.53490054
3acrosome reaction (GO:0007340)5.91405590
4fusion of sperm to egg plasma membrane (GO:0007342)5.63717210
5ribosomal small subunit assembly (GO:0000028)5.44758347
6protein polyglutamylation (GO:0018095)5.15047589
7sequestering of actin monomers (GO:0042989)5.13639004
8regulation of cilium movement (GO:0003352)5.07172809
9sperm capacitation (GO:0048240)4.68274683
10viral transcription (GO:0019083)4.64624579
11translational termination (GO:0006415)4.42583578
12telomere maintenance via semi-conservative replication (GO:0032201)4.42025272
13DNA strand elongation involved in DNA replication (GO:0006271)4.20783536
14axonemal dynein complex assembly (GO:0070286)4.19543589
15peptidyl-arginine omega-N-methylation (GO:0035247)4.18343157
16histone arginine methylation (GO:0034969)4.16445145
17microtubule depolymerization (GO:0007019)4.10289036
18base-excision repair, AP site formation (GO:0006285)4.10100615
19positive regulation of mitochondrial fission (GO:0090141)4.08527533
20plasma membrane fusion (GO:0045026)4.08099512
21translational elongation (GO:0006414)4.04404412
22spermatid development (GO:0007286)4.03516003
23microtubule severing (GO:0051013)4.00651010
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.99141708
25DNA strand elongation (GO:0022616)3.98387409
26motile cilium assembly (GO:0044458)3.94334579
27regulation of microtubule-based movement (GO:0060632)3.87618007
28protein targeting to ER (GO:0045047)3.85586853
29cotranslational protein targeting to membrane (GO:0006613)3.84944428
30rRNA modification (GO:0000154)3.83930670
31viral protein processing (GO:0019082)3.82286353
32ribosomal small subunit biogenesis (GO:0042274)3.81439111
33formation of translation preinitiation complex (GO:0001731)3.75783828
34polyamine biosynthetic process (GO:0006596)3.75198146
35response to misfolded protein (GO:0051788)3.74484401
36membrane protein intracellular domain proteolysis (GO:0031293)3.71586766
37protein localization to endoplasmic reticulum (GO:0070972)3.67043955
38pyrimidine nucleobase catabolic process (GO:0006208)3.66861291
39telomere maintenance via recombination (GO:0000722)3.65132741
40translational initiation (GO:0006413)3.63778388
41seminiferous tubule development (GO:0072520)3.63073765
42establishment of protein localization to endoplasmic reticulum (GO:0072599)3.61249718
43phosphatidylethanolamine biosynthetic process (GO:0006646)3.60492970
44maturation of SSU-rRNA (GO:0030490)3.57892416
45negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.56757008
46nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55702567
47heme biosynthetic process (GO:0006783)3.54076777
48regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.51338115
49viral life cycle (GO:0019058)3.50742987
50virion assembly (GO:0019068)3.49090404
51epithelial cilium movement (GO:0003351)3.46216803
52DNA replication initiation (GO:0006270)3.41478488
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.41205386
54antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.40616876
55antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.40616876
56sperm-egg recognition (GO:0035036)3.36830918
57negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.35357691
58phosphatidylethanolamine metabolic process (GO:0046337)3.32893642
59pseudouridine synthesis (GO:0001522)3.32890792
60negative regulation of Notch signaling pathway (GO:0045746)3.29455380
61cellular protein complex disassembly (GO:0043624)3.27301925
62proline biosynthetic process (GO:0006561)3.26990009
63peptidyl-arginine methylation (GO:0018216)3.26294993
64peptidyl-arginine N-methylation (GO:0035246)3.26294993
65negative regulation of DNA-templated transcription, elongation (GO:0032785)3.24137307
66calcium ion-dependent exocytosis (GO:0017156)3.23699435
67microtubule polymerization or depolymerization (GO:0031109)3.23079209
68telomere maintenance via telomere lengthening (GO:0010833)3.22691967
69DNA packaging (GO:0006323)3.21022339
70establishment of mitochondrion localization (GO:0051654)3.19202984
71protein complex biogenesis (GO:0070271)3.18804982
72rRNA methylation (GO:0031167)3.18081526
73mitotic recombination (GO:0006312)3.15751586
74deoxyribonucleotide catabolic process (GO:0009264)3.15728572
75cranial nerve morphogenesis (GO:0021602)3.14730325
76arginine catabolic process (GO:0006527)3.14314008
77protein-DNA complex disassembly (GO:0032986)3.13956809
78nucleosome disassembly (GO:0006337)3.13956809
79folic acid-containing compound biosynthetic process (GO:0009396)3.13781729
80pteridine-containing compound biosynthetic process (GO:0042559)3.10385827
81spermatid nucleus differentiation (GO:0007289)3.09376056
82binding of sperm to zona pellucida (GO:0007339)3.07646851
83nucleotide-excision repair, DNA gap filling (GO:0006297)3.07154585
84spermatogenesis (GO:0007283)3.06047757
85purine deoxyribonucleotide catabolic process (GO:0009155)3.05991334
86DNA unwinding involved in DNA replication (GO:0006268)3.05173793
87male gamete generation (GO:0048232)3.02691999
88chromosome condensation (GO:0030261)3.01989928
89protein retention in ER lumen (GO:0006621)3.01101611
90tooth mineralization (GO:0034505)3.00509158
91chaperone-mediated protein transport (GO:0072321)3.00306985
92protein complex disassembly (GO:0043241)2.99831406
93protein targeting to Golgi (GO:0000042)2.99749558
94sexual reproduction (GO:0019953)2.99555400
95mitochondrial respiratory chain complex I assembly (GO:0032981)2.96753670
96NADH dehydrogenase complex assembly (GO:0010257)2.96753670
97mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96753670
98ribonucleoprotein complex biogenesis (GO:0022613)2.96523438
99regulation of inclusion body assembly (GO:0090083)2.95090784
100heme metabolic process (GO:0042168)2.94793243
101mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94450889
102post-embryonic morphogenesis (GO:0009886)2.94271206
103proteasome assembly (GO:0043248)2.93468153
104RNA localization (GO:0006403)2.92343211
105multicellular organism reproduction (GO:0032504)2.91835152
106protein insertion into membrane (GO:0051205)2.91275863
107regulation of transcription involved in cell fate commitment (GO:0060850)2.90998791
108negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90793905
109mitochondrial calcium ion transport (GO:0006851)2.90519733
110transcription from mitochondrial promoter (GO:0006390)2.90080013
111nuclear-transcribed mRNA catabolic process (GO:0000956)2.88780290
112ATP synthesis coupled proton transport (GO:0015986)2.88726200
113energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88726200
114translation (GO:0006412)2.88639495
115cellular response to pH (GO:0071467)2.88262994
116negative regulation of RNA splicing (GO:0033119)2.87683362
117cellular response to zinc ion (GO:0071294)2.87652870
118retrograde transport, vesicle recycling within Golgi (GO:0000301)2.84581020
119establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.83950341
120mitochondrion transport along microtubule (GO:0047497)2.83950341
121reproduction (GO:0000003)2.83701048
122RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83548671
123tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83548671
124Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83282049
125pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.83158084
126pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.83008829
127ribosome biogenesis (GO:0042254)2.79604610
128macromolecular complex disassembly (GO:0032984)2.79601161
129deoxyribose phosphate catabolic process (GO:0046386)2.79451239
130maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.79034931
131DNA replication checkpoint (GO:0000076)2.77982161
132RNA destabilization (GO:0050779)2.77415766
133mRNA catabolic process (GO:0006402)2.77076128
134glyoxylate metabolic process (GO:0046487)2.76549685
135antigen processing and presentation via MHC class Ib (GO:0002475)2.76026833
136cilium movement (GO:0003341)2.75669093
137mitochondrial respiratory chain complex assembly (GO:0033108)2.75477054
138single fertilization (GO:0007338)2.74887569
139regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.74738350
140ribosomal large subunit biogenesis (GO:0042273)2.74734872
141antigen processing and presentation of endogenous antigen (GO:0019883)2.74631350
142response to acidic pH (GO:0010447)2.74104916
143mitochondrion degradation (GO:0000422)2.73217605
144gamete generation (GO:0007276)2.72902721
145single strand break repair (GO:0000012)2.72025757
146RNA catabolic process (GO:0006401)2.71877332
147L-phenylalanine catabolic process (GO:0006559)2.71628072
148erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.71628072
149cell wall macromolecule catabolic process (GO:0016998)2.71124706
150erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.69341169
151viral mRNA export from host cell nucleus (GO:0046784)2.67534498
152pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.66481774
153rRNA processing (GO:0006364)2.65657018
154exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65357566
155nucleoside salvage (GO:0043174)2.61621943
156proline metabolic process (GO:0006560)2.59993667
157iron-sulfur cluster assembly (GO:0016226)2.59571364
158metallo-sulfur cluster assembly (GO:0031163)2.59571364
159response to interferon-beta (GO:0035456)2.58956853
160pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.58028600
161replication fork processing (GO:0031297)2.56852204
162rRNA metabolic process (GO:0016072)2.55987690
163negative regulation of erythrocyte differentiation (GO:0045647)2.55982223
164nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.55614212
165regulation of protein heterodimerization activity (GO:0043497)2.54285668
166termination of RNA polymerase II transcription (GO:0006369)2.53721993
167porphyrin-containing compound biosynthetic process (GO:0006779)2.53062596
168mitochondrial RNA metabolic process (GO:0000959)2.52706462
169erythrocyte maturation (GO:0043249)2.52580192
170purine-containing compound salvage (GO:0043101)2.51896908
171negative regulation of phagocytosis (GO:0050765)2.50181292
172tRNA methylation (GO:0030488)2.50030240
173pentose metabolic process (GO:0019321)2.49030317
174nucleobase biosynthetic process (GO:0046112)2.48262068
175folic acid metabolic process (GO:0046655)2.47644924
176base-excision repair (GO:0006284)2.46321186
177protein targeting to membrane (GO:0006612)2.45918797
178nucleotide salvage (GO:0043173)2.44470347
179pyrimidine nucleotide catabolic process (GO:0006244)2.43591460
180negative regulation of mRNA processing (GO:0050686)2.39269054
181mitochondrial DNA metabolic process (GO:0032042)2.38455501
182spliceosomal snRNP assembly (GO:0000387)2.36291924
183pentose-phosphate shunt (GO:0006098)2.35519922
184positive regulation of B cell differentiation (GO:0045579)2.34902736
185IMP biosynthetic process (GO:0006188)2.32641534
186cellular component biogenesis (GO:0044085)2.31029442
187positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.29652144
188telomere maintenance (GO:0000723)2.29381802
189telomere organization (GO:0032200)2.28679889
190protein localization to kinetochore (GO:0034501)2.28606192
191positive regulation of gamma-delta T cell activation (GO:0046645)2.26817233
192regulation of erythrocyte differentiation (GO:0045646)2.25935660
193positive regulation of lamellipodium assembly (GO:0010592)2.25602739
194mitochondrial DNA replication (GO:0006264)2.25462766

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.54637882
2E2F7_22180533_ChIP-Seq_HELA_Human5.08552885
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.93541186
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.28013213
5MYC_22102868_ChIP-Seq_BL_Human2.53251102
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44992161
7* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.41133452
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39323709
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37740249
10ELF1_20517297_ChIP-Seq_JURKAT_Human2.37127877
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33503872
12VDR_21846776_ChIP-Seq_THP-1_Human2.31160833
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29875371
14BCL6_27268052_Chip-Seq_Bcells_Human2.22470166
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.19666017
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.19272261
17TET1_21451524_ChIP-Seq_MESCs_Mouse2.18219829
18TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.16512348
19P68_20966046_ChIP-Seq_HELA_Human2.15321334
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12087545
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.07472157
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.07104285
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.05291870
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.03939204
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96959070
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96770307
27XRN2_22483619_ChIP-Seq_HELA_Human1.96122378
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.94193438
29SCL_19346495_ChIP-Seq_HPC-7_Human1.92472413
30BCOR_27268052_Chip-Seq_Bcells_Human1.92305571
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.92221661
32* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90334960
33YY1_22570637_ChIP-Seq_MALME-3M_Human1.89347690
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81779879
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81006381
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.80337057
37CTCF_18555785_ChIP-Seq_MESCs_Mouse1.80064304
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79226594
39VDR_23849224_ChIP-Seq_CD4+_Human1.77877653
40* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76726727
41SA1_27219007_Chip-Seq_ERYTHROID_Human1.73972859
42E2F1_20622854_ChIP-Seq_HELA_Human1.73752978
43PHF8_20622854_ChIP-Seq_HELA_Human1.72697234
44FOXP3_21729870_ChIP-Seq_TREG_Human1.71305588
45CTCF_20526341_ChIP-Seq_ESCs_Human1.70962544
46GABP_19822575_ChIP-Seq_HepG2_Human1.70957143
47* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70445777
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69657925
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.68485477
50SMC4_20622854_ChIP-Seq_HELA_Human1.67804592
51CTCF_27219007_Chip-Seq_Bcells_Human1.67359341
52DCP1A_22483619_ChIP-Seq_HELA_Human1.65982555
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65498290
54* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.64734228
55* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64632133
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63938733
57ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.63129916
58FOXP1_21924763_ChIP-Seq_HESCs_Human1.60701444
59RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.59249400
60EZH2_22144423_ChIP-Seq_EOC_Human1.57711270
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57368227
62SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.54371358
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53246461
64CIITA_25753668_ChIP-Seq_RAJI_Human1.51403046
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51189135
66SA1_27219007_Chip-Seq_Bcells_Human1.50616830
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50293324
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.50039610
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.48840052
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.48540866
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47070032
72* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46768319
73SPI1_23547873_ChIP-Seq_NB4_Human1.46737920
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46038864
75CTCF_21964334_Chip-Seq_Bcells_Human1.45843550
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.44743533
77SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.41084163
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40306430
79RAC3_21632823_ChIP-Seq_H3396_Human1.40054689
80* YY1_21170310_ChIP-Seq_MESCs_Mouse1.39980716
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39481826
82* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39285918
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39113679
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38832818
85MAF_26560356_Chip-Seq_TH1_Human1.38538101
86* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38093229
87TTF2_22483619_ChIP-Seq_HELA_Human1.36731816
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.33998426
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33983485
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.33344276
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33031555
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32532243
93ERA_21632823_ChIP-Seq_H3396_Human1.31665949
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30505094
95* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29923432
96UTX_26944678_Chip-Seq_JUKART_Human1.29899263
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29716981
98* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29332403
99* VDR_24763502_ChIP-Seq_THP-1_Human1.28029257
100P300_27268052_Chip-Seq_Bcells_Human1.27625080
101* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27523472
102RUNX1_22412390_ChIP-Seq_EML_Mouse1.27516066
103MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27244938
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26171424
105* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25793878
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.24164703
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21996586
108KDM5A_27292631_Chip-Seq_BREAST_Human1.20410774
109* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20171389
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19431835
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18984372
112* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18795794
113DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18384401
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18310200
115CTCF_21964334_ChIP-Seq_BJAB-B_Human1.18254867
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18123895
117MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.17908466
118NANOG_20526341_ChIP-Seq_ESCs_Human1.16375080
119MAF_26560356_Chip-Seq_TH2_Human1.16241831
120PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16202635
121RXR_22158963_ChIP-Seq_LIVER_Mouse1.15715067
122BP1_19119308_ChIP-ChIP_Hs578T_Human1.15512799
123STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15044390
124BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14332097
125NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12483943
126RARA_24833708_ChIP-Seq_LIVER_Mouse1.12334465
127* ELK3_25401928_ChIP-Seq_HUVEC_Human1.12204589
128RARB_24833708_ChIP-Seq_LIVER_Mouse1.11869199
129MYB_26560356_Chip-Seq_TH1_Human1.11644195
130TP63_22573176_ChIP-Seq_HFKS_Human1.11516287
131* TCF7_22412390_ChIP-Seq_EML_Mouse1.11317471
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10689550
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10199003
134GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10144935
135TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09483671
136KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09352891
137UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08528104
138TFEB_21752829_ChIP-Seq_HELA_Human1.08208716
139MYB_26560356_Chip-Seq_TH2_Human1.08182210
140MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07810125
141SPI1_20517297_ChIP-Seq_HL60_Human1.06926812
142SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06851791
143E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04782956
144SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04777066
145PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04397277
146* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04075429
147TAF2_19829295_ChIP-Seq_ESCs_Human1.03780125
148EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02693698
149ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01103590
150LXR_22292898_ChIP-Seq_THP-1_Human1.00378462
151ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99916314
152RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99150176
153RACK7_27058665_Chip-Seq_MCF-7_Human0.98955943
154P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.95985999
155IRF8_21731497_ChIP-ChIP_J774_Mouse0.95736658
156FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94991139
157ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94961761
158KDM2B_26808549_Chip-Seq_DND41_Human0.94940572
159KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94677854
160MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93868632
161DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93776094
162SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93697616
163ETS1_21867929_ChIP-Seq_TH2_Mouse0.92556676
164EZH2_27294783_Chip-Seq_ESCs_Mouse0.91793463
165SOX2_21211035_ChIP-Seq_LN229_Human0.91764625
166ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91140900
167KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91135508
168PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91059219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.50309130
2MP0005451_abnormal_body_composition3.66105986
3MP0002822_catalepsy3.34409909
4MP0003693_abnormal_embryo_hatching3.23218794
5MP0002396_abnormal_hematopoietic_system3.06853517
6MP0003878_abnormal_ear_physiology3.06275956
7MP0005377_hearing/vestibular/ear_phenot3.06275956
8MP0001545_abnormal_hematopoietic_system2.91169828
9MP0005397_hematopoietic_system_phenotyp2.91169828
10MP0003656_abnormal_erythrocyte_physiolo2.88841169
11MP0002653_abnormal_ependyma_morphology2.69049630
12MP0008789_abnormal_olfactory_epithelium2.64772704
13MP0005670_abnormal_white_adipose2.60613965
14MP0005394_taste/olfaction_phenotype2.51648094
15MP0005499_abnormal_olfactory_system2.51648094
16MP0008057_abnormal_DNA_replication2.45696093
17MP0002249_abnormal_larynx_morphology2.34813861
18MP0001529_abnormal_vocalization2.31967781
19MP0010094_abnormal_chromosome_stability2.30872238
20MP0003111_abnormal_nucleus_morphology2.28128860
21MP0000685_abnormal_immune_system2.28061726
22MP0004957_abnormal_blastocyst_morpholog2.27637482
23MP0001905_abnormal_dopamine_level2.25845600
24MP0003698_abnormal_male_reproductive2.24839812
25MP0003806_abnormal_nucleotide_metabolis2.22839669
26MP0000490_abnormal_crypts_of2.19626957
27MP0003763_abnormal_thymus_physiology2.17504003
28MP0009333_abnormal_splenocyte_physiolog2.11672817
29MP0009278_abnormal_bone_marrow2.11133370
30MP0000049_abnormal_middle_ear2.07686110
31MP0003077_abnormal_cell_cycle2.05543563
32MP0001835_abnormal_antigen_presentation1.97776753
33MP0002398_abnormal_bone_marrow1.96278030
34MP0008260_abnormal_autophagy1.84472353
35MP0008058_abnormal_DNA_repair1.80186750
36MP0003436_decreased_susceptibility_to1.79832708
37MP0004859_abnormal_synaptic_plasticity1.79250944
38MP0005671_abnormal_response_to1.78543048
39MP0000689_abnormal_spleen_morphology1.78209476
40MP0001929_abnormal_gametogenesis1.77608488
41MP0009840_abnormal_foam_cell1.77456333
42MP0004808_abnormal_hematopoietic_stem1.77167608
43MP0002132_abnormal_respiratory_system1.77148970
44MP0002139_abnormal_hepatobiliary_system1.76663042
45MP0000678_abnormal_parathyroid_gland1.73851854
46MP0005365_abnormal_bile_salt1.73534786
47MP0003724_increased_susceptibility_to1.73210694
48MP0002722_abnormal_immune_system1.73074797
49MP0005464_abnormal_platelet_physiology1.71680861
50MP0005075_abnormal_melanosome_morpholog1.70532878
51MP0005257_abnormal_intraocular_pressure1.70384330
52MP0005025_abnormal_response_to1.69926556
53MP0003011_delayed_dark_adaptation1.69717854
54MP0008007_abnormal_cellular_replicative1.68200955
55MP0009785_altered_susceptibility_to1.67924816
56MP0001800_abnormal_humoral_immune1.60061736
57MP0005645_abnormal_hypothalamus_physiol1.57864001
58MP0005174_abnormal_tail_pigmentation1.57477818
59MP0002429_abnormal_blood_cell1.56017218
60MP0010030_abnormal_orbit_morphology1.55439449
61MP0005360_urolithiasis1.55312229
62MP0000716_abnormal_immune_system1.55088073
63MP0003186_abnormal_redox_activity1.54830704
64MP0006054_spinal_hemorrhage1.54309532
65MP0002234_abnormal_pharynx_morphology1.54233205
66MP0001853_heart_inflammation1.53766834
67MP0002166_altered_tumor_susceptibility1.51834891
68MP0002019_abnormal_tumor_incidence1.51109204
69MP0004147_increased_porphyrin_level1.50300930
70MP0002420_abnormal_adaptive_immunity1.48629542
71MP0001819_abnormal_immune_cell1.46055199
72MP0003191_abnormal_cellular_cholesterol1.45612939
73MP0002405_respiratory_system_inflammati1.45503147
74MP0000703_abnormal_thymus_morphology1.44979855
75MP0002723_abnormal_immune_serum1.43931994
76MP0004742_abnormal_vestibular_system1.43576050
77MP0002452_abnormal_antigen_presenting1.41679384
78MP0002161_abnormal_fertility/fecundity1.40948952
79MP0010352_gastrointestinal_tract_polyps1.37588921
80MP0010155_abnormal_intestine_physiology1.34873072
81MP0005000_abnormal_immune_tolerance1.34699887
82MP0000465_gastrointestinal_hemorrhage1.33781066
83MP0006036_abnormal_mitochondrial_physio1.32234149
84MP0005085_abnormal_gallbladder_physiolo1.29770551
85MP0005387_immune_system_phenotype1.27879423
86MP0001790_abnormal_immune_system1.27879423
87MP0000313_abnormal_cell_death1.23205233
88MP0002282_abnormal_trachea_morphology1.22662601
89MP0002419_abnormal_innate_immunity1.22310427
90MP0006276_abnormal_autonomic_nervous1.21468084
91MP0000858_altered_metastatic_potential1.19689304
92MP0006292_abnormal_olfactory_placode1.18113050
93MP0000026_abnormal_inner_ear1.17901541
94MP0003718_maternal_effect1.17464236
95MP0002006_tumorigenesis1.16189294
96MP0008469_abnormal_protein_level1.12616539
97MP0003866_abnormal_defecation1.12438609
98MP0006082_CNS_inflammation1.11238153
99MP0001873_stomach_inflammation1.10733764
100MP0000681_abnormal_thyroid_gland1.10035384
101MP0001845_abnormal_inflammatory_respons1.09003579
102MP0003786_premature_aging1.08986770
103MP0008995_early_reproductive_senescence1.07493954
104MP0000955_abnormal_spinal_cord1.04700316
105MP0000598_abnormal_liver_morphology1.04543945
106MP0002733_abnormal_thermal_nociception1.03520951
107MP0002148_abnormal_hypersensitivity_rea1.03433679
108MP0003879_abnormal_hair_cell1.03432957
109MP0000350_abnormal_cell_proliferation1.03407817
110MP0000609_abnormal_liver_physiology1.01959442
111MP0005319_abnormal_enzyme/_coenzyme1.01079904
112MP0001764_abnormal_homeostasis0.98074992
113MP0002210_abnormal_sex_determination0.96346440
114MP0003123_paternal_imprinting0.96118656
115MP0001485_abnormal_pinna_reflex0.94068309
116MP0009379_abnormal_foot_pigmentation0.92825062
117MP0008932_abnormal_embryonic_tissue0.92472997
118MP0008875_abnormal_xenobiotic_pharmacok0.91953693
119MP0003303_peritoneal_inflammation0.91921237
120MP0001963_abnormal_hearing_physiology0.90759900
121MP0001730_embryonic_growth_arrest0.90021551
122MP0005646_abnormal_pituitary_gland0.88910349
123MP0002557_abnormal_social/conspecific_i0.88304537
124MP0004133_heterotaxia0.87091837
125MP0005083_abnormal_biliary_tract0.86375169
126MP0009697_abnormal_copulation0.86064440
127MP0002080_prenatal_lethality0.85310978
128MP0009384_cardiac_valve_regurgitation0.84981091
129MP0001968_abnormal_touch/_nociception0.84317541
130MP0000750_abnormal_muscle_regeneration0.84300712
131MP0005084_abnormal_gallbladder_morpholo0.81815917
132MP0002736_abnormal_nociception_after0.81220059
133MP0004947_skin_inflammation0.80573421
134MP0000477_abnormal_intestine_morphology0.80445594
135MP0002572_abnormal_emotion/affect_behav0.80423713
136MP0000372_irregular_coat_pigmentation0.79581544
137MP0004142_abnormal_muscle_tone0.79483239
138MP0002067_abnormal_sensory_capabilities0.78644700
139MP0005220_abnormal_exocrine_pancreas0.78536083
140MP0002095_abnormal_skin_pigmentation0.77942550
141MP0000343_altered_response_to0.77246632
142MP0001270_distended_abdomen0.77051076
143MP0001970_abnormal_pain_threshold0.76833754
144MP0001145_abnormal_male_reproductive0.76754376
145MP0003638_abnormal_response/metabolism_0.76283350
146MP0001697_abnormal_embryo_size0.76282702
147MP0002735_abnormal_chemical_nociception0.75259324
148MP0002138_abnormal_hepatobiliary_system0.74668976
149MP0003300_gastrointestinal_ulcer0.73973132
150MP0003172_abnormal_lysosome_physiology0.73951221
151MP0000566_synostosis0.73946684
152MP0003567_abnormal_fetal_cardiomyocyte0.72942711
153MP0000653_abnormal_sex_gland0.72327431
154MP0000358_abnormal_cell_content/0.72023582
155MP0009763_increased_sensitivity_to0.71906948
156MP0002086_abnormal_extraembryonic_tissu0.71822871
157MP0003635_abnormal_synaptic_transmissio0.68393713
158MP0000516_abnormal_urinary_system0.68065895
159MP0005367_renal/urinary_system_phenotyp0.68065895
160MP0003943_abnormal_hepatobiliary_system0.67844765
161MP0009053_abnormal_anal_canal0.67296671
162MP0002229_neurodegeneration0.67248693
163MP0004510_myositis0.66504409
164MP0005636_abnormal_mineral_homeostasis0.66406170
165MP0000015_abnormal_ear_pigmentation0.66318316
166MP0005058_abnormal_lysosome_morphology0.66154064
167MP0005379_endocrine/exocrine_gland_phen0.66137846
168MP0002752_abnormal_somatic_nervous0.65686295
169MP0005423_abnormal_somatic_nervous0.65132612
170MP0000534_abnormal_ureter_morphology0.64564878
171MP0008872_abnormal_physiological_respon0.63661807
172MP0002882_abnormal_neuron_morphology0.63515836
173MP0003880_abnormal_central_pattern0.62258419
174MP0005584_abnormal_enzyme/coenzyme_acti0.62158624
175MP0004811_abnormal_neuron_physiology0.61546802
176MP0006035_abnormal_mitochondrial_morpho0.61496419
177MP0010386_abnormal_urinary_bladder0.60061876
178MP0008569_lethality_at_weaning0.59670699
179MP0003137_abnormal_impulse_conducting0.59437045

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.47638772
2Abnormality of cells of the erythroid lineage (HP:0012130)5.28378109
3Abnormality of the heme biosynthetic pathway (HP:0010472)4.86223241
4Severe visual impairment (HP:0001141)4.31954501
5Tubulointerstitial nephritis (HP:0001970)4.00083315
6Thrombocytosis (HP:0001894)3.96245324
7Aplastic anemia (HP:0001915)3.85753105
8Reticulocytopenia (HP:0001896)3.83794506
9Renal Fanconi syndrome (HP:0001994)3.57444754
10Cholecystitis (HP:0001082)3.38127786
11Abnormal gallbladder physiology (HP:0012438)3.38127786
12Petechiae (HP:0000967)3.37764767
13Absent/shortened dynein arms (HP:0200106)3.35887097
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.35887097
15Abnormal mitochondria in muscle tissue (HP:0008316)3.32428111
16Elevated erythrocyte sedimentation rate (HP:0003565)3.27873673
17Reduced antithrombin III activity (HP:0001976)3.27194119
18Mitochondrial inheritance (HP:0001427)3.26875143
19Pallor (HP:0000980)3.23412422
20Abnormal respiratory epithelium morphology (HP:0012253)3.20076789
21Abnormal respiratory motile cilium morphology (HP:0005938)3.20076789
22Prolonged bleeding time (HP:0003010)3.17247343
23IgM deficiency (HP:0002850)3.16686805
24Cerebral palsy (HP:0100021)3.10713913
25Abnormality of the aortic arch (HP:0012303)3.05643065
26Congenital malformation of the right heart (HP:0011723)3.04438743
27Double outlet right ventricle (HP:0001719)3.04438743
28Acute necrotizing encephalopathy (HP:0006965)3.04265178
29Acute encephalopathy (HP:0006846)2.97013989
30Abnormal respiratory motile cilium physiology (HP:0012261)2.94101952
31Type I transferrin isoform profile (HP:0003642)2.92907280
32Abnormal ciliary motility (HP:0012262)2.88886693
33Chronic otitis media (HP:0000389)2.82846316
34Myokymia (HP:0002411)2.82535433
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.81030289
36Birth length less than 3rd percentile (HP:0003561)2.80180620
37Abnormality of T cell physiology (HP:0011840)2.79954747
38Epistaxis (HP:0000421)2.79116761
39Pustule (HP:0200039)2.76790270
40Macrocytic anemia (HP:0001972)2.75862632
41Poikiloderma (HP:0001029)2.74186320
42Male infertility (HP:0003251)2.74122289
43Hyperthyroidism (HP:0000836)2.71840117
44Impaired platelet aggregation (HP:0003540)2.69552786
45Abnormal platelet function (HP:0011869)2.69552786
46Increased serum ferritin (HP:0003281)2.69055498
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.66891104
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.64313136
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.64313136
50Truncus arteriosus (HP:0001660)2.62258652
51Cholelithiasis (HP:0001081)2.58555602
52Polyphagia (HP:0002591)2.58032610
53Microcytic anemia (HP:0001935)2.55684071
54Amblyopia (HP:0000646)2.51597195
55Oral leukoplakia (HP:0002745)2.50876214
56Microretrognathia (HP:0000308)2.47990498
57Hypochromic anemia (HP:0001931)2.46706349
58Abnormality of reticulocytes (HP:0004312)2.46299017
59Abnormality of dental color (HP:0011073)2.45654974
60Spastic paraparesis (HP:0002313)2.45323328
61Exertional dyspnea (HP:0002875)2.45047531
62Increased CSF lactate (HP:0002490)2.43519706
63Hypertensive crisis (HP:0100735)2.40383593
64Retinal dysplasia (HP:0007973)2.36399549
65Abnormality of T cells (HP:0002843)2.34455209
66Generalized aminoaciduria (HP:0002909)2.34324372
67Rough bone trabeculation (HP:0100670)2.30339890
68Atelectasis (HP:0100750)2.30310921
69Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30303274
70Prolonged neonatal jaundice (HP:0006579)2.29990724
71Broad distal phalanx of finger (HP:0009836)2.28835360
72Chronic obstructive pulmonary disease (HP:0006510)2.28193625
73Obstructive lung disease (HP:0006536)2.28193625
74Hypoplastic left heart (HP:0004383)2.27270869
75Hyperbilirubinemia (HP:0002904)2.24743182
76Abnormality of iron homeostasis (HP:0011031)2.24211545
77Asymmetric septal hypertrophy (HP:0001670)2.22957158
78Selective tooth agenesis (HP:0001592)2.21258482
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20807787
80Abnormal protein N-linked glycosylation (HP:0012347)2.20807787
81Abnormal protein glycosylation (HP:0012346)2.20807787
82Abnormal glycosylation (HP:0012345)2.20807787
83Abnormal gallbladder morphology (HP:0012437)2.20260202
84Abnormality of the parathyroid morphology (HP:0011766)2.19107808
85Seborrheic dermatitis (HP:0001051)2.18830637
86Poikilocytosis (HP:0004447)2.18819423
87Recurrent viral infections (HP:0004429)2.18308135
88Albinism (HP:0001022)2.17813169
89Down-sloping shoulders (HP:0200021)2.17430049
90Chronic hepatic failure (HP:0100626)2.16292654
91Nasal polyposis (HP:0100582)2.15640638
92Recurrent fungal infections (HP:0002841)2.15368076
93Failure to thrive in infancy (HP:0001531)2.14974265
94Emotional lability (HP:0000712)2.14669096
95Polycythemia (HP:0001901)2.14155694
96Abnormality of the nasal mucosa (HP:0000433)2.12771875
97Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12683801
98Myositis (HP:0100614)2.12625433
99Unilateral renal agenesis (HP:0000122)2.11859770
100Hyperglycinemia (HP:0002154)2.11677208
101Muscle fiber atrophy (HP:0100295)2.11371784
102Abnormality of pyrimidine metabolism (HP:0004353)2.11295612
103Recurrent bronchitis (HP:0002837)2.11125748
104Nephronophthisis (HP:0000090)2.08854742
105Pancytopenia (HP:0001876)2.08680985
106Panhypogammaglobulinemia (HP:0003139)2.08634640
107Abnormality of monocarboxylic acid metabolism (HP:0010996)2.06821483
108Abnormality of transition element cation homeostasis (HP:0011030)2.06607261
109Myelodysplasia (HP:0002863)2.03078257
110Optic nerve coloboma (HP:0000588)2.02492644
111Progressive macrocephaly (HP:0004481)2.01850960
112Increased muscle lipid content (HP:0009058)2.00438510
113Sclerocornea (HP:0000647)1.99996923
114Infertility (HP:0000789)1.99849752
115Lymphoma (HP:0002665)1.99695219
116Aplasia/Hypoplasia of the earlobes (HP:0009906)1.98085242
117Lactic acidosis (HP:0003128)1.97457004
118Cellulitis (HP:0100658)1.97442335
119Recurrent abscess formation (HP:0002722)1.95670383
120Increased intramyocellular lipid droplets (HP:0012240)1.94500394
121Aplasia/Hypoplasia of the brainstem (HP:0007362)1.93895677
122Hypoplasia of the brainstem (HP:0002365)1.93895677
123Esotropia (HP:0000565)1.93524255
124Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92451717
125Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92372095
126Abnormality of the anterior horn cell (HP:0006802)1.91792659
127Degeneration of anterior horn cells (HP:0002398)1.91792659
128Cerebral edema (HP:0002181)1.90048793
129Hepatic necrosis (HP:0002605)1.89667359
130Progressive muscle weakness (HP:0003323)1.89548003
131IgG deficiency (HP:0004315)1.89105189
1323-Methylglutaconic aciduria (HP:0003535)1.87965342
133Abnormality of renal resorption (HP:0011038)1.87542775
134Hand muscle atrophy (HP:0009130)1.87305273
135Abnormality of the gallbladder (HP:0005264)1.86502553
136Hypoalphalipoproteinemia (HP:0003233)1.86171084
137Acute lymphatic leukemia (HP:0006721)1.86051158
138Basal cell carcinoma (HP:0002671)1.85994307
139Gastrointestinal inflammation (HP:0004386)1.84670873
140Progressive microcephaly (HP:0000253)1.84377622
141Acanthocytosis (HP:0001927)1.83830269
142Type 2 muscle fiber atrophy (HP:0003554)1.83674544
143Gingival bleeding (HP:0000225)1.83414988
144Multiple enchondromatosis (HP:0005701)1.82778514
145Absent thumb (HP:0009777)1.81201838
146Recurrent bacterial skin infections (HP:0005406)1.81075995
147Autoimmune thrombocytopenia (HP:0001973)1.79888853
148Recurrent pneumonia (HP:0006532)1.79393943
149Stage 5 chronic kidney disease (HP:0003774)1.79361160
150Abnormal delayed hypersensitivity skin test (HP:0002963)1.79196325
151Hypobetalipoproteinemia (HP:0003563)1.78751962
152Occipital encephalocele (HP:0002085)1.77417249
153Purpura (HP:0000979)1.76171890
154Abnormality of the prostate (HP:0008775)1.76144724
155Meningitis (HP:0001287)1.75717899
156Eczematoid dermatitis (HP:0000976)1.75555792
157Neutropenia (HP:0001875)1.75514293
158Increased serum lactate (HP:0002151)1.75437555
159Urticaria (HP:0001025)1.75334098
160Hypertriglyceridemia (HP:0002155)1.74711238
161Hypoplasia of the thymus (HP:0000778)1.74503011
162Breast hypoplasia (HP:0003187)1.73530417
163Hepatocellular necrosis (HP:0001404)1.72976425
164Delayed CNS myelination (HP:0002188)1.72710021
165Agitation (HP:0000713)1.72382617
166Abnormal trabecular bone morphology (HP:0100671)1.72112382
167Nausea (HP:0002018)1.71654546
168Impulsivity (HP:0100710)1.70351929
169Opisthotonus (HP:0002179)1.69656038
170Respiratory failure (HP:0002878)1.69575272
171Hypoparathyroidism (HP:0000829)1.69370575
172Combined immunodeficiency (HP:0005387)1.69290945
173Reticulocytosis (HP:0001923)1.68957805
174Patellar aplasia (HP:0006443)1.68937541
175Hypoplastic heart (HP:0001961)1.68819764
176Pulmonary fibrosis (HP:0002206)1.68144932
177Increased IgM level (HP:0003496)1.67996496
178Skin rash (HP:0000988)1.64827378
179Abnormality of the fingertips (HP:0001211)1.62738122
180Abnormality of cells of the lymphoid lineage (HP:0012140)1.62564636

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.81868046
2NME23.77192247
3PLK43.25390634
4PIM22.86552801
5STK162.80477029
6MAP4K12.68680952
7ERN12.52714735
8MAP3K112.36114504
9LIMK12.23920945
10KDR2.17186598
11PRKD32.15266060
12EIF2AK12.14437063
13MAP3K102.10900806
14TESK22.03785091
15MAP4K21.98047115
16BUB11.97800620
17BCKDK1.93183078
18CDC71.89982614
19WEE11.87742078
20EEF2K1.79717376
21DYRK31.76943699
22BLK1.75425996
23MAP2K71.73716316
24ARAF1.72726321
25CDK71.66725345
26KIT1.64596089
27DYRK21.63176424
28ZAP701.62883392
29BTK1.59631179
30NEK21.51903746
31TRIB31.48253284
32FLT31.45623748
33RPS6KA41.44686878
34VRK11.40462072
35MAP2K31.36954490
36TBK11.36223011
37ACVR1B1.33565118
38JAK31.32124467
39CSNK1G31.30658300
40EIF2AK31.30175974
41PIM11.24243191
42IRAK41.21984209
43MAPKAPK31.20588067
44INSRR1.19739294
45MATK1.18926901
46TEC1.16577613
47TYK21.15428049
48ABL21.15136749
49DDR21.15069874
50CDK191.13285472
51MARK11.12762581
52TAOK11.10937930
53TAOK31.09487965
54SIK21.08117408
55RPS6KB21.07586733
56MAP3K61.06090000
57PKN21.05896917
58STK101.03203910
59MAPK111.01442650
60SCYL21.01395319
61BRSK21.01220264
62CDK120.99503218
63CSNK1A1L0.99108007
64LMTK20.98134007
65TLK10.97221705
66PLK20.96392186
67CSNK1G20.96086514
68GRK60.96051702
69CDK40.95547920
70SIK30.95012070
71MAPK150.94806058
72LRRK20.94405190
73TAOK20.93088812
74TXK0.92112911
75ATR0.89446182
76DAPK10.88511974
77SIK10.87611601
78SYK0.84200137
79STK380.83372177
80IKBKE0.82849085
81TGFBR10.81032130
82SMG10.80548305
83PLK10.80435015
84RPS6KA60.76289804
85CSF1R0.75782564
86TNK20.75673918
87ICK0.74773046
88LYN0.74281463
89DYRK1B0.72564287
90AURKB0.70847023
91CDK80.70248617
92RPS6KL10.70245001
93RPS6KC10.70245001
94MKNK20.69589320
95EPHB10.68869166
96HIPK20.68013292
97MARK20.67648559
98CSK0.66913821
99MAP3K40.66496719
100NME10.66144894
101TGFBR20.66063015
102MAP3K80.65017892
103MAP2K20.64948690
104IKBKB0.64679191
105FGFR40.64255266
106MAPK40.64119043
107AURKA0.62650938
108WNK30.60879500
109NLK0.60799904
110CDK60.58384732
111PAK40.58149274
112BRAF0.58039531
113SRPK10.57550075
114CSNK1G10.56130434
115ILK0.55461951
116STK40.55364962
117BRSK10.54658885
118LCK0.54369751
119PASK0.54246200
120TRIM280.53394049
121PKN10.53017537
122EPHB20.52837183
123CDK140.52829514
124EPHA20.51834895
125PRKD20.51432949
126RPS6KA20.51155729
127MKNK10.50901876
128IRAK30.50144696
129PINK10.47946261
130CSNK2A10.47684690
131CHEK20.47025637
132CCNB10.46884369
133RPS6KA10.45968034
134DAPK30.45726730
135TESK10.45391283
136RAF10.44816213
137MAPKAPK20.44803945
138MAP3K30.44667196
139PIK3CG0.43470580
140PTK2B0.43396866
141PDPK10.42971186
142MAPK130.39802939
143EPHA30.39358711
144CDK11A0.38668241
145PAK10.37958461
146NUAK10.36428829
147TAF10.36104018
148CAMK2G0.35971948
149BCR0.35370270
150MUSK0.33702824
151MAP2K40.31910008
152CASK0.30579274
153PRKD10.29438359
154CAMKK10.29198030
155PRKG20.28035122
156MINK10.27973644
157BMX0.27282748
158CDK150.26326655
159MAP3K10.26124619
160CDK180.25890887
161PRKCD0.25288832
162BRD40.25032110

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.71926132
2Ribosome_Homo sapiens_hsa030104.00750421
3Oxidative phosphorylation_Homo sapiens_hsa001903.58752544
4Mismatch repair_Homo sapiens_hsa034303.49628035
5Base excision repair_Homo sapiens_hsa034103.09026631
6Sulfur relay system_Homo sapiens_hsa041222.69125409
7Huntingtons disease_Homo sapiens_hsa050162.65831874
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.44611345
9Spliceosome_Homo sapiens_hsa030402.37324275
10Folate biosynthesis_Homo sapiens_hsa007902.23760699
11Pyrimidine metabolism_Homo sapiens_hsa002402.21722038
12Homologous recombination_Homo sapiens_hsa034402.20026638
13Nucleotide excision repair_Homo sapiens_hsa034202.09416098
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07536233
15Proteasome_Homo sapiens_hsa030502.02906586
16RNA polymerase_Homo sapiens_hsa030201.98240334
17One carbon pool by folate_Homo sapiens_hsa006701.92016452
18Alzheimers disease_Homo sapiens_hsa050101.91844912
19Fatty acid biosynthesis_Homo sapiens_hsa000611.80672175
20Synaptic vesicle cycle_Homo sapiens_hsa047211.79872530
21Phenylalanine metabolism_Homo sapiens_hsa003601.79319257
22Primary immunodeficiency_Homo sapiens_hsa053401.78225114
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.74122441
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.58722393
25RNA transport_Homo sapiens_hsa030131.56929293
26Steroid biosynthesis_Homo sapiens_hsa001001.52983417
27Cell cycle_Homo sapiens_hsa041101.52754794
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51885968
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.48217440
30Vibrio cholerae infection_Homo sapiens_hsa051101.47938448
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46117817
32Tyrosine metabolism_Homo sapiens_hsa003501.44188343
33Fatty acid elongation_Homo sapiens_hsa000621.43631984
34Cardiac muscle contraction_Homo sapiens_hsa042601.39640094
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37859648
36Pentose phosphate pathway_Homo sapiens_hsa000301.36262555
37Collecting duct acid secretion_Homo sapiens_hsa049661.34242874
38Fatty acid metabolism_Homo sapiens_hsa012121.30390315
39Selenocompound metabolism_Homo sapiens_hsa004501.27869345
40p53 signaling pathway_Homo sapiens_hsa041151.24769278
41Herpes simplex infection_Homo sapiens_hsa051681.21408777
42RNA degradation_Homo sapiens_hsa030181.21040961
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20965260
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18539555
45Sulfur metabolism_Homo sapiens_hsa009201.16722141
46Fanconi anemia pathway_Homo sapiens_hsa034601.16465420
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14613528
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13519413
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13227591
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.11683254
51Caffeine metabolism_Homo sapiens_hsa002321.10653742
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06173337
53Protein export_Homo sapiens_hsa030601.05678950
54Butanoate metabolism_Homo sapiens_hsa006501.05331358
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03887023
56Pyruvate metabolism_Homo sapiens_hsa006201.02356272
57Non-homologous end-joining_Homo sapiens_hsa034501.01858935
58Antigen processing and presentation_Homo sapiens_hsa046120.99873215
59Endocytosis_Homo sapiens_hsa041440.99360332
60Biosynthesis of amino acids_Homo sapiens_hsa012300.99295614
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98403335
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95324757
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.95264892
64N-Glycan biosynthesis_Homo sapiens_hsa005100.93639853
65Acute myeloid leukemia_Homo sapiens_hsa052210.93091161
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.92762484
67Measles_Homo sapiens_hsa051620.90883614
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90095502
69Leishmaniasis_Homo sapiens_hsa051400.89430445
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86596180
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86203334
72Purine metabolism_Homo sapiens_hsa002300.85494307
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83289405
74Other glycan degradation_Homo sapiens_hsa005110.81931682
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79977073
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79964114
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78590087
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78400135
79Basal transcription factors_Homo sapiens_hsa030220.78350593
80Legionellosis_Homo sapiens_hsa051340.76618583
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.75105273
82Shigellosis_Homo sapiens_hsa051310.74161709
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.74059017
84Olfactory transduction_Homo sapiens_hsa047400.72005837
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71749358
86Chemical carcinogenesis_Homo sapiens_hsa052040.71354459
87Galactose metabolism_Homo sapiens_hsa000520.70519816
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69174199
89Thyroid cancer_Homo sapiens_hsa052160.69102115
90Epstein-Barr virus infection_Homo sapiens_hsa051690.67375522
91Hematopoietic cell lineage_Homo sapiens_hsa046400.66156262
92Regulation of autophagy_Homo sapiens_hsa041400.65971240
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65711810
94Fatty acid degradation_Homo sapiens_hsa000710.65257808
95mRNA surveillance pathway_Homo sapiens_hsa030150.64862999
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63926476
97Glutathione metabolism_Homo sapiens_hsa004800.63749442
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62936083
99B cell receptor signaling pathway_Homo sapiens_hsa046620.62047012
100Apoptosis_Homo sapiens_hsa042100.61294435
101Peroxisome_Homo sapiens_hsa041460.59875595
102Hepatitis B_Homo sapiens_hsa051610.59479401
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.56439246
104Carbon metabolism_Homo sapiens_hsa012000.55827276
105PPAR signaling pathway_Homo sapiens_hsa033200.55757283
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55194691
107Salmonella infection_Homo sapiens_hsa051320.55137442
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55098360
109Phagosome_Homo sapiens_hsa041450.54553577
110Staphylococcus aureus infection_Homo sapiens_hsa051500.53486194
111Arachidonic acid metabolism_Homo sapiens_hsa005900.52637963
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.51180526
113Lysine degradation_Homo sapiens_hsa003100.50779130
114Notch signaling pathway_Homo sapiens_hsa043300.50580882
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.49889465
116Lysosome_Homo sapiens_hsa041420.49187624
117Arginine and proline metabolism_Homo sapiens_hsa003300.48473494
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.48363340
119Tryptophan metabolism_Homo sapiens_hsa003800.48336679
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44053026
121HTLV-I infection_Homo sapiens_hsa051660.42990033
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42124549
123Viral carcinogenesis_Homo sapiens_hsa052030.41842039
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.41681586
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41310837
126Chronic myeloid leukemia_Homo sapiens_hsa052200.40266012
127Metabolic pathways_Homo sapiens_hsa011000.38467534
128beta-Alanine metabolism_Homo sapiens_hsa004100.37994781
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37632895
130Influenza A_Homo sapiens_hsa051640.36809372
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35401159
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34779480
133Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34638789
134Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34456622
135Fructose and mannose metabolism_Homo sapiens_hsa000510.34263124
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34260426
137Parkinsons disease_Homo sapiens_hsa050120.32238371
138Retinol metabolism_Homo sapiens_hsa008300.31202556
139Complement and coagulation cascades_Homo sapiens_hsa046100.31003257
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30474176
141Bladder cancer_Homo sapiens_hsa052190.30358850
142Propanoate metabolism_Homo sapiens_hsa006400.28530530
143Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27909422
144Arginine biosynthesis_Homo sapiens_hsa002200.27842632
145Fat digestion and absorption_Homo sapiens_hsa049750.24497125
146Cocaine addiction_Homo sapiens_hsa050300.23065819
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20833753
148Axon guidance_Homo sapiens_hsa043600.20231485
149Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17482154
150Basal cell carcinoma_Homo sapiens_hsa052170.17213719

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