MOV10L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is similar to a mouse gene that encodes a putative RNA helicase and shows testis-specific expression. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)9.94955740
2synaptonemal complex assembly (GO:0007130)8.71466128
3regulation of meiosis I (GO:0060631)8.44553802
4synaptonemal complex organization (GO:0070193)8.41934428
5male meiosis (GO:0007140)8.33581833
6cardiac myofibril assembly (GO:0055003)6.31542954
7chromosome organization involved in meiosis (GO:0070192)6.06154286
8meiotic nuclear division (GO:0007126)5.86471061
9behavioral response to nicotine (GO:0035095)5.71922137
10male meiosis I (GO:0007141)5.59101430
11negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.52016420
12sarcomere organization (GO:0045214)5.38338016
13gene silencing by RNA (GO:0031047)5.34423103
14myofibril assembly (GO:0030239)5.14326839
15negative regulation of potassium ion transmembrane transport (GO:1901380)5.10909069
16DNA methylation (GO:0006306)4.64358368
17DNA alkylation (GO:0006305)4.64358368
18tricarboxylic acid cycle (GO:0006099)4.62784290
19meiosis I (GO:0007127)4.61143752
20cardiac muscle cell development (GO:0055013)4.51867084
21nuclear pore organization (GO:0006999)4.46247087
22nuclear pore complex assembly (GO:0051292)4.41980215
23response to pheromone (GO:0019236)4.41541990
24cardiac muscle contraction (GO:0060048)4.36833031
25muscle filament sliding (GO:0030049)4.31743693
26actin-myosin filament sliding (GO:0033275)4.31743693
27cardiac cell development (GO:0055006)4.21750462
28heart contraction (GO:0060047)4.12384527
29heart process (GO:0003015)4.12384527
30positive regulation of meiosis (GO:0045836)4.10046873
31fusion of sperm to egg plasma membrane (GO:0007342)4.00896226
32cardiac muscle tissue morphogenesis (GO:0055008)3.99841363
33regulation of cilium movement (GO:0003352)3.99152727
34gene silencing (GO:0016458)3.98194942
35meiotic cell cycle process (GO:1903046)3.97926375
36oogenesis (GO:0048477)3.94461697
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.89088824
38gamma-aminobutyric acid transport (GO:0015812)3.88053011
39ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.87165353
40protein polyglutamylation (GO:0018095)3.84177880
41epithelial cilium movement (GO:0003351)3.82972629
42positive regulation of meiotic cell cycle (GO:0051446)3.81061611
43cilium or flagellum-dependent cell motility (GO:0001539)3.75951350
44DNA methylation or demethylation (GO:0044728)3.74021561
45heart trabecula formation (GO:0060347)3.71781696
46regulation of microtubule-based movement (GO:0060632)3.68190785
47actomyosin structure organization (GO:0031032)3.65445946
48negative regulation of meiosis (GO:0045835)3.64764720
49regulation of sarcomere organization (GO:0060297)3.62986634
50mitotic chromosome condensation (GO:0007076)3.61835110
51actin-mediated cell contraction (GO:0070252)3.60711189
52cardiac muscle hypertrophy (GO:0003300)3.59290220
53regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.59248035
54muscle tissue morphogenesis (GO:0060415)3.57946963
55axon ensheathment in central nervous system (GO:0032291)3.57036845
56central nervous system myelination (GO:0022010)3.57036845
57resolution of meiotic recombination intermediates (GO:0000712)3.52312094
58meiotic cell cycle (GO:0051321)3.51483614
59nonmotile primary cilium assembly (GO:0035058)3.47134057
60axoneme assembly (GO:0035082)3.46084836
61spermatid development (GO:0007286)3.44055002
62cellular ketone body metabolic process (GO:0046950)3.40222818
63acrosome reaction (GO:0007340)3.38935978
64negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.37997414
65striated muscle hypertrophy (GO:0014897)3.36302277
66ventricular cardiac muscle cell development (GO:0055015)3.34887788
67platelet dense granule organization (GO:0060155)3.33303819
68oocyte development (GO:0048599)3.32447497
69regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.32438542
70regulation of actin filament-based movement (GO:1903115)3.32022673
71ventricular cardiac muscle cell action potential (GO:0086005)3.31658051
72regulation of cardioblast differentiation (GO:0051890)3.29447819
73meiotic chromosome segregation (GO:0045132)3.29049489
74adult heart development (GO:0007512)3.27474907
75reciprocal DNA recombination (GO:0035825)3.26067026
76reciprocal meiotic recombination (GO:0007131)3.26067026
77sex differentiation (GO:0007548)3.23649231
78heterochromatin organization (GO:0070828)3.22654706
79pore complex assembly (GO:0046931)3.22030945
80mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.21766428
81synapsis (GO:0007129)3.20726104
82carnitine shuttle (GO:0006853)3.20117193
83regulation of acyl-CoA biosynthetic process (GO:0050812)3.19043001
84cilium movement (GO:0003341)3.18941069
85bundle of His cell to Purkinje myocyte communication (GO:0086069)3.18632968
86positive regulation of male gonad development (GO:2000020)3.15741624
87binding of sperm to zona pellucida (GO:0007339)3.15439499
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14025243
89* germ cell development (GO:0007281)3.13738437
90protein localization to cilium (GO:0061512)3.12665178
91striated muscle contraction (GO:0006941)3.10214511
92oxidative phosphorylation (GO:0006119)3.10059927
93sperm-egg recognition (GO:0035036)3.09125274
94negative regulation of telomere maintenance (GO:0032205)3.09103490
95regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.09011611
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06922927
97negative regulation of striated muscle cell apoptotic process (GO:0010664)3.05249528
98regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.04481890
99sister chromatid cohesion (GO:0007062)3.03458833
100attachment of spindle microtubules to kinetochore (GO:0008608)3.02732236
101regulation of the force of heart contraction (GO:0002026)3.02299212
102positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.02289907
103regulation of relaxation of muscle (GO:1901077)2.99386352
104plasma membrane fusion (GO:0045026)2.98962051
105regulation of coenzyme metabolic process (GO:0051196)2.97934712
106regulation of cofactor metabolic process (GO:0051193)2.97934712
107negative regulation of synaptic transmission, GABAergic (GO:0032229)2.97503204
108establishment of protein localization to mitochondrial membrane (GO:0090151)2.97434085
109ketone body metabolic process (GO:1902224)2.96277597
110behavioral response to ethanol (GO:0048149)2.95927800
111DNA modification (GO:0006304)2.94988916
112regulation of histone H3-K9 methylation (GO:0051570)2.93643491
113carnitine transmembrane transport (GO:1902603)2.92198415
114centriole replication (GO:0007099)2.91799641
115tryptophan catabolic process (GO:0006569)2.91038328
116indole-containing compound catabolic process (GO:0042436)2.91038328
117indolalkylamine catabolic process (GO:0046218)2.91038328
118cilium morphogenesis (GO:0060271)2.90772682
119L-fucose catabolic process (GO:0042355)2.90525222
120fucose catabolic process (GO:0019317)2.90525222
121L-fucose metabolic process (GO:0042354)2.90525222
122sulfation (GO:0051923)2.89513411
123muscle hypertrophy (GO:0014896)2.88698345
124transmission of nerve impulse (GO:0019226)2.87461027
125neuronal action potential (GO:0019228)2.87401156
126female gamete generation (GO:0007292)2.86966572
127nephron tubule morphogenesis (GO:0072078)2.86298559
128nephron epithelium morphogenesis (GO:0072088)2.86298559
129detection of light stimulus involved in sensory perception (GO:0050962)2.85745478
130detection of light stimulus involved in visual perception (GO:0050908)2.85745478
131multicellular organism reproduction (GO:0032504)2.85687130
132ATP synthesis coupled proton transport (GO:0015986)2.85563124
133energy coupled proton transport, down electrochemical gradient (GO:0015985)2.85563124
134positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.84294411
135regulation of skeletal muscle contraction (GO:0014819)2.84036230
136retinal cone cell development (GO:0046549)2.83149707
137* male gamete generation (GO:0048232)2.80598490
138* spermatogenesis (GO:0007283)2.80584839
139cilium organization (GO:0044782)2.79588952
140DNA packaging (GO:0006323)2.79426481
141acrosome assembly (GO:0001675)2.78070443
142tongue development (GO:0043586)2.77818839
143sperm motility (GO:0030317)2.77397375
144regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.76005677
145axonemal dynein complex assembly (GO:0070286)2.75942520
146photoreceptor cell maintenance (GO:0045494)2.74076146
147indolalkylamine metabolic process (GO:0006586)2.73504031
148cilium assembly (GO:0042384)2.71783658
149presynaptic membrane organization (GO:0097090)2.70306124
150pyrimidine nucleobase catabolic process (GO:0006208)2.69044515
151regulation of nuclear cell cycle DNA replication (GO:0033262)2.68170790
152histone H4-K12 acetylation (GO:0043983)2.66000506
153protein K11-linked deubiquitination (GO:0035871)2.65772776
154negative regulation of response to food (GO:0032096)2.58925247
155negative regulation of appetite (GO:0032099)2.58925247
156regulation of protein polyubiquitination (GO:1902914)2.57711392
157mitochondrial respiratory chain complex I assembly (GO:0032981)2.56840891
158NADH dehydrogenase complex assembly (GO:0010257)2.56840891
159mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.56840891
160negative regulation of mast cell activation (GO:0033004)2.54137981
161protein complex biogenesis (GO:0070271)2.52910595
162kynurenine metabolic process (GO:0070189)2.50414599
163intraciliary transport (GO:0042073)2.49681269
164negative regulation of DNA-dependent DNA replication (GO:2000104)2.47641909
165cAMP catabolic process (GO:0006198)2.47487806
166urinary tract smooth muscle contraction (GO:0014848)2.44821267
167calcium ion-dependent exocytosis (GO:0017156)2.43353781
168water-soluble vitamin biosynthetic process (GO:0042364)2.43323921
169positive regulation of gastrulation (GO:2000543)2.43170259
170substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.42234904
171substrate-independent telencephalic tangential migration (GO:0021826)2.42234904
172centriole assembly (GO:0098534)2.41385923
173negative regulation of cytosolic calcium ion concentration (GO:0051481)2.40217433
174somite rostral/caudal axis specification (GO:0032525)2.38258759
175piRNA metabolic process (GO:0034587)12.7106379

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.43944936
2E2F7_22180533_ChIP-Seq_HELA_Human4.56947603
3EZH2_22144423_ChIP-Seq_EOC_Human3.66072345
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.55449282
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.28004016
6VDR_22108803_ChIP-Seq_LS180_Human3.19128135
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.79396151
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63673848
9ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.62264096
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61451244
11GBX2_23144817_ChIP-Seq_PC3_Human2.61256109
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.49894285
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36546979
14* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.33988808
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32538311
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.31617950
17FUS_26573619_Chip-Seq_HEK293_Human2.28760009
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26118095
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.25595144
20TAF15_26573619_Chip-Seq_HEK293_Human2.21555601
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21147616
22AR_21909140_ChIP-Seq_LNCAP_Human2.17554351
23MYCN_18555785_ChIP-Seq_MESCs_Mouse2.16715695
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14467180
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.09028539
26MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.08880795
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.07673500
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06887740
29* TBX20_22328084_ChIP-Seq_HEART_Mouse2.06739363
30* TBX20_22080862_ChIP-Seq_HEART_Mouse2.06739363
31BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06512885
32FLI1_27457419_Chip-Seq_LIVER_Mouse2.05402526
33POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03974202
34IGF1R_20145208_ChIP-Seq_DFB_Human2.03007870
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.02981698
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.98678747
37P300_19829295_ChIP-Seq_ESCs_Human1.97383469
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96714127
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91426267
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.84688787
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84126193
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.82870019
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.82870019
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.82870019
45ER_23166858_ChIP-Seq_MCF-7_Human1.82086931
46RNF2_27304074_Chip-Seq_NSC_Mouse1.81294992
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81026391
48NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.79493230
49EWS_26573619_Chip-Seq_HEK293_Human1.78919566
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76839498
51GATA4_21415370_ChIP-Seq_HL-1_Mouse1.76792803
52ZNF263_19887448_ChIP-Seq_K562_Human1.76694319
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74163897
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74091177
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.74005335
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72383937
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.72376467
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70190609
59REST_21632747_ChIP-Seq_MESCs_Mouse1.64590757
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64082346
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62847844
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60348206
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60187829
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59374063
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59113942
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59113942
67CBP_20019798_ChIP-Seq_JUKART_Human1.54566092
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54566092
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51687821
70TP53_22573176_ChIP-Seq_HFKS_Human1.50947033
71STAT3_23295773_ChIP-Seq_U87_Human1.48803125
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.48518727
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48316088
74AR_25329375_ChIP-Seq_VCAP_Human1.46643517
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46222497
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45118074
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.43818274
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43726690
79SMAD4_21799915_ChIP-Seq_A2780_Human1.42784266
80ETS1_20019798_ChIP-Seq_JURKAT_Human1.41937245
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40853007
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40325883
83* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40116051
84GATA1_26923725_Chip-Seq_HPCs_Mouse1.39871429
85EED_16625203_ChIP-ChIP_MESCs_Mouse1.39690360
86TCF4_23295773_ChIP-Seq_U87_Human1.39247039
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38967078
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38937876
89EZH2_27304074_Chip-Seq_ESCs_Mouse1.37628564
90RUNX2_22187159_ChIP-Seq_PCA_Human1.36894444
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35900768
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34038425
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33124414
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32986330
95EST1_17652178_ChIP-ChIP_JURKAT_Human1.32382699
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31534606
97* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31113100
98FOXA1_25329375_ChIP-Seq_VCAP_Human1.29592246
99FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29592246
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28560416
101HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27739401
102SOX2_19829295_ChIP-Seq_ESCs_Human1.27456303
103NANOG_19829295_ChIP-Seq_ESCs_Human1.27456303
104AR_21572438_ChIP-Seq_LNCaP_Human1.27106024
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25665673
106YY1_21170310_ChIP-Seq_MESCs_Mouse1.25280607
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24964365
108CIITA_25753668_ChIP-Seq_RAJI_Human1.24766884
109DCP1A_22483619_ChIP-Seq_HELA_Human1.24028786
110ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23947098
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23890763
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23665511
113EZH2_27294783_Chip-Seq_ESCs_Mouse1.22951961
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.22856667
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22714061
116MYC_18940864_ChIP-ChIP_HL60_Human1.22422956
117XRN2_22483619_ChIP-Seq_HELA_Human1.22216936
118TBX5_21415370_ChIP-Seq_HL-1_Mouse1.20835769
119SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20640550
120NCOR_22424771_ChIP-Seq_293T_Human1.20322464
121GATA3_21878914_ChIP-Seq_MCF-7_Human1.20215269
122NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19938572
123KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19677225
124* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19381197
125SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18556782
126FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18363752
127SMAD3_21741376_ChIP-Seq_EPCs_Human1.16499457
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15253589
129KDM5A_27292631_Chip-Seq_BREAST_Human1.14938550
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14785269
131NANOG_21062744_ChIP-ChIP_HESCs_Human1.14302596
132TCF4_22108803_ChIP-Seq_LS180_Human1.13910870
133REST_18959480_ChIP-ChIP_MESCs_Mouse1.13694687
134SMAD4_21741376_ChIP-Seq_EPCs_Human1.13648438
135GABP_19822575_ChIP-Seq_HepG2_Human1.13484692
136KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13394952
137JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12969958
138DROSHA_22980978_ChIP-Seq_HELA_Human1.12733048
139CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10709709
140SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09788457
141MYC_19829295_ChIP-Seq_ESCs_Human1.09386672
142GATA1_22025678_ChIP-Seq_K562_Human1.08680599
143SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08500713
144NFE2_27457419_Chip-Seq_LIVER_Mouse1.08035581
145PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07748504
146MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07723904
147TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06345714
148CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06212916
149PRDM14_20953172_ChIP-Seq_ESCs_Human1.05437623
150OCT4_19829295_ChIP-Seq_ESCs_Human1.03724425
151RNF2_27304074_Chip-Seq_ESCs_Mouse1.03716837
152* RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03564637
153ERA_21632823_ChIP-Seq_H3396_Human1.03541378
154HOXB7_26014856_ChIP-Seq_BT474_Human1.03007622
155AR_20517297_ChIP-Seq_VCAP_Human1.02947809
156NANOG_18555785_Chip-Seq_ESCs_Mouse1.02875463
157YY1_22570637_ChIP-Seq_MALME-3M_Human1.02067092
158NOTCH1_21737748_ChIP-Seq_TLL_Human1.01250687
159CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01233813
160FLI1_21867929_ChIP-Seq_TH2_Mouse1.00943171
161SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99486789
162WDR5_24793694_ChIP-Seq_LNCAP_Human0.99445000
163POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99314118
164IRF1_19129219_ChIP-ChIP_H3396_Human0.99075985
165TAF2_19829295_ChIP-Seq_ESCs_Human0.97794078
166EZH2_27294783_Chip-Seq_NPCs_Mouse0.97090565
167BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93681167
168DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91719730
169ISL1_27105846_Chip-Seq_CPCs_Mouse0.91179252
170GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90346420
171E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88993315
172PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88304310
173E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87628828
174VDR_23849224_ChIP-Seq_CD4+_Human0.86430213
175SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86358618
176ZNF274_21170338_ChIP-Seq_K562_Hela0.86194011
177FOXP3_21729870_ChIP-Seq_TREG_Human0.85726773
178AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85229036
179DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84317028
180HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84143703
181SRF_21415370_ChIP-Seq_HL-1_Mouse0.83920128
182GABP_17652178_ChIP-ChIP_JURKAT_Human0.83419671
183PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83389410
184FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82975787
185SPI1_20517297_ChIP-Seq_HL60_Human0.82916505
186TTF2_22483619_ChIP-Seq_HELA_Human0.82172530
187E2F1_20622854_ChIP-Seq_HELA_Human0.80751813
188* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80642913
189* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.76268043
190TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75824289
191ESR1_20079471_ChIP-ChIP_T-47D_Human0.74952022
192BCAT_22108803_ChIP-Seq_LS180_Human0.72392695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0008877_abnormal_DNA_methylation5.54046509
2MP0004084_abnormal_cardiac_muscle5.21026172
3MP0003646_muscle_fatigue4.49425080
4MP0002837_dystrophic_cardiac_calcinosis3.86225599
5MP0004036_abnormal_muscle_relaxation3.69023759
6MP0000751_myopathy3.56288524
7MP0004215_abnormal_myocardial_fiber3.34854972
8MP0008995_early_reproductive_senescence3.31003976
9MP0005330_cardiomyopathy2.98203951
10MP0000749_muscle_degeneration2.90650205
11MP0005410_abnormal_fertilization2.82790486
12MP0005423_abnormal_somatic_nervous2.80973174
13MP0003136_yellow_coat_color2.70590920
14* MP0002210_abnormal_sex_determination2.68398979
15MP0000569_abnormal_digit_pigmentation2.64183663
16* MP0001929_abnormal_gametogenesis2.55932985
17MP0006292_abnormal_olfactory_placode2.45369377
18MP0004087_abnormal_muscle_fiber2.39160078
19MP0002972_abnormal_cardiac_muscle2.35593542
20MP0010630_abnormal_cardiac_muscle2.31064067
21MP0003221_abnormal_cardiomyocyte_apopto2.30415297
22MP0005551_abnormal_eye_electrophysiolog2.28499971
23MP0006138_congestive_heart_failure2.27202709
24* MP0003698_abnormal_male_reproductive2.19868686
25* MP0001145_abnormal_male_reproductive2.11923581
26MP0003786_premature_aging2.11094037
27MP0008775_abnormal_heart_ventricle2.09741954
28MP0005174_abnormal_tail_pigmentation2.06340769
29MP0005385_cardiovascular_system_phenoty2.04017079
30MP0001544_abnormal_cardiovascular_syste2.04017079
31MP0001968_abnormal_touch/_nociception2.01781059
32MP0003137_abnormal_impulse_conducting1.97943860
33MP0004233_abnormal_muscle_weight1.97303205
34MP0010094_abnormal_chromosome_stability1.94666223
35MP0001486_abnormal_startle_reflex1.91485870
36MP0005620_abnormal_muscle_contractility1.91437835
37MP0009745_abnormal_behavioral_response1.88497035
38MP0002269_muscular_atrophy1.86443640
39MP0009379_abnormal_foot_pigmentation1.84699353
40* MP0000653_abnormal_sex_gland1.83879857
41MP0008057_abnormal_DNA_replication1.82819869
42MP0006072_abnormal_retinal_apoptosis1.80171110
43MP0002106_abnormal_muscle_physiology1.78621084
44MP0004885_abnormal_endolymph1.75841196
45MP0000427_abnormal_hair_cycle1.75676627
46MP0003878_abnormal_ear_physiology1.74978104
47MP0005377_hearing/vestibular/ear_phenot1.74978104
48MP0004142_abnormal_muscle_tone1.73973727
49MP0004147_increased_porphyrin_level1.73360186
50MP0000383_abnormal_hair_follicle1.72645400
51MP0003787_abnormal_imprinting1.71127792
52MP0002102_abnormal_ear_morphology1.70264701
53MP0003123_paternal_imprinting1.69840094
54MP0004484_altered_response_of1.67804864
55MP0008058_abnormal_DNA_repair1.64092216
56MP0002272_abnormal_nervous_system1.63773220
57MP0009046_muscle_twitch1.62906966
58MP0002736_abnormal_nociception_after1.62085359
59MP0003567_abnormal_fetal_cardiomyocyte1.61939204
60MP0000750_abnormal_muscle_regeneration1.61914518
61MP0001485_abnormal_pinna_reflex1.60820549
62MP0005389_reproductive_system_phenotype1.60020035
63MP0000015_abnormal_ear_pigmentation1.55252373
64MP0002127_abnormal_cardiovascular_syste1.55091922
65MP0005623_abnormal_meninges_morphology1.54997936
66MP0003828_pulmonary_edema1.54928562
67MP0005646_abnormal_pituitary_gland1.54490874
68MP0004085_abnormal_heartbeat1.52018229
69MP0003195_calcinosis1.50656083
70MP0006036_abnormal_mitochondrial_physio1.50480420
71MP0006276_abnormal_autonomic_nervous1.49814352
72MP0003111_abnormal_nucleus_morphology1.46822846
73MP0004742_abnormal_vestibular_system1.46752491
74MP0002638_abnormal_pupillary_reflex1.46029485
75MP0005253_abnormal_eye_physiology1.45954879
76MP0005084_abnormal_gallbladder_morpholo1.44459429
77MP0001730_embryonic_growth_arrest1.43025612
78MP0003950_abnormal_plasma_membrane1.42289071
79MP0000631_abnormal_neuroendocrine_gland1.41868848
80MP0002938_white_spotting1.40937469
81MP0002572_abnormal_emotion/affect_behav1.39484140
82MP0002064_seizures1.37534242
83MP0005369_muscle_phenotype1.37322586
84MP0003077_abnormal_cell_cycle1.36841498
85MP0001501_abnormal_sleep_pattern1.36386029
86MP0000778_abnormal_nervous_system1.34858214
87MP0003119_abnormal_digestive_system1.34594222
88MP0001986_abnormal_taste_sensitivity1.34120452
89MP0001188_hyperpigmentation1.32517920
90MP0004145_abnormal_muscle_electrophysio1.31595268
91MP0005167_abnormal_blood-brain_barrier1.30544638
92MP0000026_abnormal_inner_ear1.29127121
93MP0002735_abnormal_chemical_nociception1.28796255
94MP0004957_abnormal_blastocyst_morpholog1.28391952
95MP0002876_abnormal_thyroid_physiology1.24449843
96MP0003635_abnormal_synaptic_transmissio1.23662900
97MP0003984_embryonic_growth_retardation1.23307565
98MP0001984_abnormal_olfaction1.22017449
99MP0004133_heterotaxia1.21959898
100MP0000759_abnormal_skeletal_muscle1.20840302
101* MP0002161_abnormal_fertility/fecundity1.20400505
102MP0003283_abnormal_digestive_organ1.20029329
103MP0002088_abnormal_embryonic_growth/wei1.19200763
104MP0003880_abnormal_central_pattern1.18298480
105MP0002822_catalepsy1.17341413
106MP0002557_abnormal_social/conspecific_i1.16700184
107MP0000266_abnormal_heart_morphology1.15713393
108MP0000049_abnormal_middle_ear1.15034316
109MP0005670_abnormal_white_adipose1.14944796
110MP0001672_abnormal_embryogenesis/_devel1.14564223
111MP0005380_embryogenesis_phenotype1.14564223
112MP0002095_abnormal_skin_pigmentation1.14317347
113MP0002067_abnormal_sensory_capabilities1.13587152
114MP0000747_muscle_weakness1.13341058
115MP0004510_myositis1.11677289
116MP0001970_abnormal_pain_threshold1.11534628
117MP0002184_abnormal_innervation1.10605845
118MP0001963_abnormal_hearing_physiology1.09947537
119MP0003011_delayed_dark_adaptation1.09380849
120MP0004130_abnormal_muscle_cell1.09044028
121MP0005195_abnormal_posterior_eye1.07260944
122MP0005645_abnormal_hypothalamus_physiol1.06093257
123MP0002063_abnormal_learning/memory/cond1.05926282
124MP0002733_abnormal_thermal_nociception1.05924709
125MP0003121_genomic_imprinting1.05703733
126MP0000647_abnormal_sebaceous_gland1.05438093
127MP0008004_abnormal_stomach_pH1.05292247
128MP0002928_abnormal_bile_duct1.03425751
129MP0008007_abnormal_cellular_replicative1.02504577
130MP0001919_abnormal_reproductive_system1.02305507
131MP0005666_abnormal_adipose_tissue1.01796083
132MP0000566_synostosis1.00623951
133MP0008875_abnormal_xenobiotic_pharmacok0.99972397
134MP0001293_anophthalmia0.99126983
135MP0008872_abnormal_physiological_respon0.99096973
136MP0008789_abnormal_olfactory_epithelium0.98697395
137MP0002752_abnormal_somatic_nervous0.98208489
138MP0003693_abnormal_embryo_hatching0.97558907
139MP0000955_abnormal_spinal_cord0.96072709
140MP0001529_abnormal_vocalization0.95273621
141MP0004924_abnormal_behavior0.94669076
142MP0005386_behavior/neurological_phenoty0.94669076
143MP0002734_abnormal_mechanical_nocicepti0.94565623
144MP0001697_abnormal_embryo_size0.91728969
145MP0003718_maternal_effect0.91686814
146MP0002653_abnormal_ependyma_morphology0.90023468
147MP0003122_maternal_imprinting0.89626599
148MP0003937_abnormal_limbs/digits/tail_de0.88427215
149MP0004197_abnormal_fetal_growth/weight/0.88262387
150MP0006035_abnormal_mitochondrial_morpho0.87472882
151MP0001905_abnormal_dopamine_level0.85501235
152MP0002234_abnormal_pharynx_morphology0.82602768
153MP0001727_abnormal_embryo_implantation0.79744736
154MP0002084_abnormal_developmental_patter0.79591175
155MP0002163_abnormal_gland_morphology0.78888273
156MP0005391_vision/eye_phenotype0.78051507
157MP0002085_abnormal_embryonic_tissue0.75842650
158MP0002080_prenatal_lethality0.74622303
159MP0005266_abnormal_metabolism0.73598000
160MP0008932_abnormal_embryonic_tissue0.72934814
161MP0002086_abnormal_extraembryonic_tissu0.72423057
162MP0000350_abnormal_cell_proliferation0.69406143
163MP0003566_abnormal_cell_adhesion0.67172749
164MP0002332_abnormal_exercise_endurance0.66720994
165MP0002160_abnormal_reproductive_system0.64356790
166MP0010307_abnormal_tumor_latency0.62070621
167MP0001119_abnormal_female_reproductive0.61985864
168MP0002925_abnormal_cardiovascular_devel0.61641331
169MP0005451_abnormal_body_composition0.60591103
170MP0004808_abnormal_hematopoietic_stem0.60405052
171MP0002128_abnormal_blood_circulation0.59963735
172MP0009672_abnormal_birth_weight0.59402949
173MP0005647_abnormal_sex_gland0.58791332
174MP0004185_abnormal_adipocyte_glucose0.57863234
175MP0002108_abnormal_muscle_morphology0.56246120
176MP0000313_abnormal_cell_death0.54760223
177MP0000343_altered_response_to0.54693106
178MP0003115_abnormal_respiratory_system0.52610670
179MP0004272_abnormal_basement_membrane0.52595221
180MP0001784_abnormal_fluid_regulation0.52305564
181MP0005375_adipose_tissue_phenotype0.50267576
182MP0001661_extended_life_span0.50217291
183MP0003699_abnormal_female_reproductive0.47464105

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.30040995
2Ventricular tachycardia (HP:0004756)5.34048906
3Atrial fibrillation (HP:0005110)4.97730999
4Calf muscle hypertrophy (HP:0008981)4.68449062
5Exercise-induced myalgia (HP:0003738)4.67473475
6Exercise-induced muscle cramps (HP:0003710)4.60578270
7Primary atrial arrhythmia (HP:0001692)4.58608484
8Hyporeflexia of lower limbs (HP:0002600)4.47870752
9Supraventricular tachycardia (HP:0004755)4.38906881
10Azoospermia (HP:0000027)4.34721911
11Supraventricular arrhythmia (HP:0005115)4.31690230
12Lipoatrophy (HP:0100578)4.28393101
13Pancreatic cysts (HP:0001737)4.26427862
14Type II lissencephaly (HP:0007260)4.19663285
15Muscle hypertrophy of the lower extremities (HP:0008968)4.12395228
16Nephronophthisis (HP:0000090)4.09006946
17Pancreatic fibrosis (HP:0100732)4.07282149
18Abnormality of midbrain morphology (HP:0002418)4.04409137
19Molar tooth sign on MRI (HP:0002419)4.04409137
20True hermaphroditism (HP:0010459)3.93590982
21Gonadotropin excess (HP:0000837)3.93549175
22Subaortic stenosis (HP:0001682)3.93204200
23Abnormality of the left ventricular outflow tract (HP:0011103)3.93204200
24Abnormal spermatogenesis (HP:0008669)3.87317710
25Abnormality of the calf musculature (HP:0001430)3.78284879
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.78252661
27Bundle branch block (HP:0011710)3.74546972
28Myoglobinuria (HP:0002913)3.74163892
29Abnormality of the lower motor neuron (HP:0002366)3.73434152
30Muscle fiber splitting (HP:0003555)3.70041792
31Palpitations (HP:0001962)3.65228030
32Syncope (HP:0001279)3.60866283
33Abnormality of the renal medulla (HP:0100957)3.55096010
34Right ventricular cardiomyopathy (HP:0011663)3.48079308
35Dilated cardiomyopathy (HP:0001644)3.36959886
36Ventricular arrhythmia (HP:0004308)3.35957939
37Chronic hepatic failure (HP:0100626)3.27284053
38Medial flaring of the eyebrow (HP:0010747)3.25310877
39Prolonged QT interval (HP:0001657)3.21911364
40Rhabdomyolysis (HP:0003201)3.21638654
41Congenital stationary night blindness (HP:0007642)3.19343091
42Absent/shortened dynein arms (HP:0200106)3.16200533
43Dynein arm defect of respiratory motile cilia (HP:0012255)3.16200533
44Hyperventilation (HP:0002883)3.06760025
45Ventricular fibrillation (HP:0001663)3.05989054
46Asymmetric septal hypertrophy (HP:0001670)3.05266335
47Cystic liver disease (HP:0006706)3.04098209
48Difficulty running (HP:0009046)2.97443787
49Tubular atrophy (HP:0000092)2.94809140
50Abnormality of the renal cortex (HP:0011035)2.92610688
51Congenital, generalized hypertrichosis (HP:0004540)2.84815653
52Heart block (HP:0012722)2.81679949
53Concave nail (HP:0001598)2.76843274
54Attenuation of retinal blood vessels (HP:0007843)2.71923214
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68878715
56Abnormality of alanine metabolism (HP:0010916)2.68878715
57Hyperalaninemia (HP:0003348)2.68878715
58Gait imbalance (HP:0002141)2.68709948
59Atrioventricular block (HP:0001678)2.65855225
60Male infertility (HP:0003251)2.65438045
61Left ventricular hypertrophy (HP:0001712)2.65015772
62Acute necrotizing encephalopathy (HP:0006965)2.64221968
63Inability to walk (HP:0002540)2.63105104
64Optic nerve hypoplasia (HP:0000609)2.62491176
65Sclerocornea (HP:0000647)2.60091578
66Abnormal mitochondria in muscle tissue (HP:0008316)2.58832191
67Increased corneal curvature (HP:0100692)2.58641280
68Keratoconus (HP:0000563)2.58641280
69Increased connective tissue (HP:0009025)2.58284645
70EMG: myopathic abnormalities (HP:0003458)2.55746996
71Difficulty climbing stairs (HP:0003551)2.55721503
72Abnormal atrioventricular conduction (HP:0005150)2.55511480
73Congenital primary aphakia (HP:0007707)2.54715926
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.47880503
7511 pairs of ribs (HP:0000878)2.46838853
76EMG: neuropathic changes (HP:0003445)2.45488052
77Large for gestational age (HP:0001520)2.43757051
78Double outlet right ventricle (HP:0001719)2.41228578
79Congenital malformation of the right heart (HP:0011723)2.41228578
80Cerebellar dysplasia (HP:0007033)2.38854193
81Abnormal rod and cone electroretinograms (HP:0008323)2.37860085
82Abnormal drinking behavior (HP:0030082)2.35528395
83Polydipsia (HP:0001959)2.35528395
84Papillary thyroid carcinoma (HP:0002895)2.35016210
85Lissencephaly (HP:0001339)2.34413994
86Retinal dysplasia (HP:0007973)2.33041394
87Abnormal respiratory motile cilium physiology (HP:0012261)2.30976761
88Decreased central vision (HP:0007663)2.30276402
89Ragged-red muscle fibers (HP:0003200)2.29980850
90Progressive cerebellar ataxia (HP:0002073)2.29919035
91Limb dystonia (HP:0002451)2.29719419
92Metaphyseal cupping (HP:0003021)2.27700703
93Horizontal nystagmus (HP:0000666)2.25231840
94Methylmalonic acidemia (HP:0002912)2.23858213
95Nephrogenic diabetes insipidus (HP:0009806)2.23811668
96Hypoplastic left heart (HP:0004383)2.23208037
97Occipital encephalocele (HP:0002085)2.22866680
98Diaphragmatic weakness (HP:0009113)2.22104209
99Aplasia/Hypoplasia of the tongue (HP:0010295)2.21319348
100Rimmed vacuoles (HP:0003805)2.20069973
101Anencephaly (HP:0002323)2.19474955
102Pendular nystagmus (HP:0012043)2.19195074
103Genital tract atresia (HP:0001827)2.18498906
104Hepatic necrosis (HP:0002605)2.17974096
105Abnormal EKG (HP:0003115)2.16822171
106Congenital hepatic fibrosis (HP:0002612)2.16142969
107Rhinitis (HP:0012384)2.16084637
108Infertility (HP:0000789)2.15439772
109Abolished electroretinogram (ERG) (HP:0000550)2.15038578
110Vaginal atresia (HP:0000148)2.14690118
111Abnormality of macular pigmentation (HP:0008002)2.10437954
112Stomach cancer (HP:0012126)2.10098639
113Progressive macrocephaly (HP:0004481)2.06565531
114Acute encephalopathy (HP:0006846)2.06315490
115Oligodactyly (hands) (HP:0001180)2.06297501
116Bony spicule pigmentary retinopathy (HP:0007737)2.05994466
117Male pseudohermaphroditism (HP:0000037)2.05121617
118Areflexia of lower limbs (HP:0002522)2.04995806
119Progressive inability to walk (HP:0002505)2.04330145
120Furrowed tongue (HP:0000221)2.04214551
121Palmoplantar keratoderma (HP:0000982)2.04138266
122Ependymoma (HP:0002888)2.04120143
123Cerebral edema (HP:0002181)2.02015504
124Focal motor seizures (HP:0011153)1.99549890
125Gaze-evoked nystagmus (HP:0000640)1.98657087
126Abnormal respiratory motile cilium morphology (HP:0005938)1.98058846
127Abnormal respiratory epithelium morphology (HP:0012253)1.98058846
128Fibular hypoplasia (HP:0003038)1.97748256
129Tubulointerstitial nephritis (HP:0001970)1.97072786
130Poor coordination (HP:0002370)1.96113015
131Pachygyria (HP:0001302)1.95865370
132Neoplasm of the adrenal gland (HP:0100631)1.94430209
133Pheochromocytoma (HP:0002666)1.91539390
134Facial diplegia (HP:0001349)1.91100688
135Abnormality of the pons (HP:0007361)1.90725278
136Abnormal biliary tract physiology (HP:0012439)1.89231020
137Bile duct proliferation (HP:0001408)1.89231020
138Myotonia (HP:0002486)1.88546625
139Limb-girdle muscle weakness (HP:0003325)1.87861829
140Missing ribs (HP:0000921)1.87494588
141Hepatocellular necrosis (HP:0001404)1.85439959
142Increased CSF lactate (HP:0002490)1.85298839
143Exercise intolerance (HP:0003546)1.83294299
144Selective tooth agenesis (HP:0001592)1.82746266
145Neck muscle weakness (HP:0000467)1.81444659
146Transposition of the great arteries (HP:0001669)1.80642421
147Abnormal connection of the cardiac segments (HP:0011545)1.80642421
148Abnormal ventriculo-arterial connection (HP:0011563)1.80642421
149Tachypnea (HP:0002789)1.80057472
150Nausea (HP:0002018)1.79346771
151Amyotrophic lateral sclerosis (HP:0007354)1.78858126
152Abnormality of the vocal cords (HP:0008777)1.78810364
153Polyuria (HP:0000103)1.78652069
154Mitochondrial inheritance (HP:0001427)1.78442363
155Bulbous nose (HP:0000414)1.78385963
156Hypoplasia of the pons (HP:0012110)1.78081447
157Abnormality of the labia minora (HP:0012880)1.77799071
158Impulsivity (HP:0100710)1.77085208
159Postaxial hand polydactyly (HP:0001162)1.76454334
1603-Methylglutaconic aciduria (HP:0003535)1.76381581
161Postaxial foot polydactyly (HP:0001830)1.75699943
162Chromsome breakage (HP:0040012)1.75271350
163Astigmatism (HP:0000483)1.74580991
164Tubulointerstitial abnormality (HP:0001969)1.73914711
165Methylmalonic aciduria (HP:0012120)1.73841954
166Distal lower limb muscle weakness (HP:0009053)1.73129217
167Scotoma (HP:0000575)1.73104291
168Multicystic kidney dysplasia (HP:0000003)1.72689101
169Abnormality of DNA repair (HP:0003254)1.72014308
170Hamartoma of the eye (HP:0010568)1.71572538
171Non-midline cleft lip (HP:0100335)1.71433582
172Anterior segment dysgenesis (HP:0007700)1.71274668
173Progressive external ophthalmoplegia (HP:0000590)1.70897801
174Dandy-Walker malformation (HP:0001305)1.69936264
175Preaxial hand polydactyly (HP:0001177)1.69909075
176Hemiparesis (HP:0001269)1.68970168
177Febrile seizures (HP:0002373)1.68358362
178Prominent supraorbital ridges (HP:0000336)1.68308196
179Neoplasm of the rectum (HP:0100743)1.68001530
180Dysmetric saccades (HP:0000641)1.67908901
181Muscle stiffness (HP:0003552)1.67633620
182Abnormal ciliary motility (HP:0012262)1.67619216
183Duplicated collecting system (HP:0000081)1.67428152
184Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.66848600
185Absent rod-and cone-mediated responses on ERG (HP:0007688)1.66574177
186Broad-based gait (HP:0002136)1.66526197
187Genetic anticipation (HP:0003743)1.66393515
188Hypoplastic heart (HP:0001961)1.66139421
189Abnormality of the foot musculature (HP:0001436)1.66042312
190Abnormality of the renal collecting system (HP:0004742)1.65463255
191Gonadal dysgenesis (HP:0000133)1.63886909
192Upper motor neuron abnormality (HP:0002127)1.62481514

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.69586267
2PDK35.69586267
3CDK124.42344216
4PDK23.41033535
5MAP4K22.99301155
6OBSCN2.98194367
7ADRBK22.97496012
8MYLK2.79747217
9FRK2.76099180
10CASK2.70779449
11TTN2.70106713
12CDC72.68406669
13STK242.40400206
14PRKD32.32285771
15STK38L2.19863075
16ICK2.18611394
17LMTK22.17950565
18PKN22.15444337
19INSRR2.07610630
20NEK12.03514030
21ACVR1B2.02882499
22MET1.98373761
23BMPR1B1.87096853
24NUAK11.82047817
25BRD41.79432227
26GRK11.77361502
27NEK21.75509327
28OXSR11.74943042
29WEE11.72005506
30ZAK1.69016631
31MAPK131.62637792
32TLK11.57025272
33PLK21.54847557
34TESK11.54602896
35MAPK151.52222662
36PHKG21.49278763
37PHKG11.49278763
38WNK41.43875183
39PTK2B1.40623445
40CDC42BPA1.38611924
41CDK191.38385451
42DMPK1.36002484
43TTK1.33661813
44MARK11.29037423
45BRSK21.19866792
46STK41.18439017
47TRIB31.17083205
48TAOK31.15995471
49DYRK21.15907345
50WNK11.14646514
51ADRBK11.13832749
52CSF1R1.11580509
53PRKCG1.11113398
54STK31.10618753
55DAPK21.08167220
56PLK41.07498014
57VRK11.07367309
58PLK11.01461447
59BCKDK1.00919696
60MAP3K40.97738018
61MAP2K70.94622157
62MTOR0.94070262
63TXK0.93829074
64PINK10.92989478
65CHEK10.92473048
66NTRK30.90783804
67ATR0.87607492
68STK390.82957410
69EPHB20.81092458
70FGR0.80495848
71RIPK10.79981026
72PNCK0.79825886
73ATM0.79340870
74PRKCE0.78755078
75TNIK0.78475626
76CDK40.77144641
77TRIM280.76803819
78BMX0.73808297
79CAMK10.73250121
80MUSK0.72249658
81CAMK1D0.70701565
82TYRO30.69721320
83TAF10.67225781
84PIK3CA0.66439029
85NTRK20.64940415
86EPHA40.63902960
87CDK70.63849240
88PRKAA10.62922421
89STK380.62372215
90MAPKAPK50.62158168
91AURKB0.61470447
92STK110.59439053
93MARK30.59353816
94CAMK2A0.58174503
95ILK0.57520170
96LIMK10.56892228
97FLT30.56748487
98BRSK10.55062135
99CAMK40.52220772
100MAP2K40.51730623
101PAK30.51381358
102BUB10.51348331
103FGFR20.51040501
104ROCK10.50022486
105MAP2K20.49679301
106CHEK20.48910369
107LATS10.47621045
108MAPKAPK30.47339592
109SRPK10.47265905
110PRKCZ0.45535045
111MAP3K100.45490040
112CAMKK20.44978054
113CDK20.44881001
114WNK30.44551542
115DYRK1A0.44338840
116CDK90.43976577
117PRKACB0.43668178
118MAP3K30.43626840
119TIE10.43401814
120CAMK1G0.42584637
121TSSK60.42311101
122PRKG10.41980615
123DAPK30.41279450
124CDK10.40301395
125SGK10.39490235
126PLK30.38884563
127KIT0.37522825
128CDK50.37449439
129PDGFRB0.37265710
130PRKACA0.37159890
131PRKDC0.36854137
132PRKCI0.36810718
133PRKD10.36774248
134RPS6KA50.36577053
135MKNK20.35095634
136MELK0.33756791
137CDK30.32903866
138MAP3K50.32506933
139TEC0.31706624
140IKBKB0.31119937
141CSNK1G20.30555186
142ITK0.30507374
143CAMK2D0.30053883
144CSNK1D0.29868359
145RPS6KA10.29815996
146PRKCA0.29188027
147PRKCQ0.28953533
148IGF1R0.28540572
149UHMK10.27969741
150PDGFRA0.27936050
151RPS6KA60.27934275
152RET0.26142801
153MINK10.25131576
154IRAK10.25047703
155STK160.24905064
156CSNK1G10.24750377
157GSK3B0.23755767
158CSNK1E0.23673015
159PAK20.23432802
160TRPM70.22859065
161TGFBR10.21799266
162FGFR10.20644957
163GRK70.20588823
164PRKAA20.20042501
165PASK0.19481636
166LATS20.19319505
167AKT10.19166929
168CSNK2A20.18864763
169PAK40.17626466
170MAPK80.17517482

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.20906066
2Cardiac muscle contraction_Homo sapiens_hsa042603.79128206
3Phototransduction_Homo sapiens_hsa047443.24155552
4Parkinsons disease_Homo sapiens_hsa050122.89610289
5Huntingtons disease_Homo sapiens_hsa050162.75419715
6Propanoate metabolism_Homo sapiens_hsa006402.75124704
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.72504889
8Basal transcription factors_Homo sapiens_hsa030222.62070274
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59091539
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58158886
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.50521348
12Dilated cardiomyopathy_Homo sapiens_hsa054142.45449114
13Oxidative phosphorylation_Homo sapiens_hsa001902.45119785
14Nicotine addiction_Homo sapiens_hsa050332.44080857
15Carbon metabolism_Homo sapiens_hsa012002.41557493
16Pyruvate metabolism_Homo sapiens_hsa006202.25546005
17Nitrogen metabolism_Homo sapiens_hsa009102.23693946
18RNA transport_Homo sapiens_hsa030132.13756539
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.10950422
20Protein export_Homo sapiens_hsa030601.97159293
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90909629
22Dorso-ventral axis formation_Homo sapiens_hsa043201.86129769
23Fatty acid degradation_Homo sapiens_hsa000711.85313803
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84189965
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.80639460
26mRNA surveillance pathway_Homo sapiens_hsa030151.78848719
27Alzheimers disease_Homo sapiens_hsa050101.77215712
28Taste transduction_Homo sapiens_hsa047421.75255758
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.74736501
30Homologous recombination_Homo sapiens_hsa034401.71962936
31Morphine addiction_Homo sapiens_hsa050321.71731108
32Fatty acid metabolism_Homo sapiens_hsa012121.70682035
33Olfactory transduction_Homo sapiens_hsa047401.63723050
34Lysine degradation_Homo sapiens_hsa003101.58744019
35Mismatch repair_Homo sapiens_hsa034301.55509777
36Ribosome_Homo sapiens_hsa030101.54927288
37Regulation of autophagy_Homo sapiens_hsa041401.54749612
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54401986
39RNA polymerase_Homo sapiens_hsa030201.53131934
40Ether lipid metabolism_Homo sapiens_hsa005651.52264718
41Biosynthesis of amino acids_Homo sapiens_hsa012301.51590884
42Cell cycle_Homo sapiens_hsa041101.51450110
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51346564
44Fanconi anemia pathway_Homo sapiens_hsa034601.49820761
45DNA replication_Homo sapiens_hsa030301.47044224
46Tryptophan metabolism_Homo sapiens_hsa003801.45352969
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.37849642
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36808411
49Circadian entrainment_Homo sapiens_hsa047131.34931341
50Glutamatergic synapse_Homo sapiens_hsa047241.34921430
51Oocyte meiosis_Homo sapiens_hsa041141.34458300
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31878846
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.30901844
54RNA degradation_Homo sapiens_hsa030181.30511229
55GABAergic synapse_Homo sapiens_hsa047271.30425028
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28647095
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28614858
58Caffeine metabolism_Homo sapiens_hsa002321.24587108
59Spliceosome_Homo sapiens_hsa030401.23555547
60Proteasome_Homo sapiens_hsa030501.23463627
61Glucagon signaling pathway_Homo sapiens_hsa049221.22460418
62Selenocompound metabolism_Homo sapiens_hsa004501.20417061
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19300185
64Serotonergic synapse_Homo sapiens_hsa047261.18911224
65ABC transporters_Homo sapiens_hsa020101.14022649
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13866960
67Insulin secretion_Homo sapiens_hsa049111.13056442
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12635237
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11940272
70Sulfur relay system_Homo sapiens_hsa041221.11618066
71Nucleotide excision repair_Homo sapiens_hsa034201.10142192
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05211854
73Fatty acid biosynthesis_Homo sapiens_hsa000611.03101814
74Viral myocarditis_Homo sapiens_hsa054161.01484097
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97853100
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96654789
77Pentose phosphate pathway_Homo sapiens_hsa000300.93818602
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90609109
79Non-homologous end-joining_Homo sapiens_hsa034500.90074889
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.88998699
81Base excision repair_Homo sapiens_hsa034100.87229674
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84997107
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.83227691
84Cocaine addiction_Homo sapiens_hsa050300.82850391
85Tight junction_Homo sapiens_hsa045300.82370207
86Chemical carcinogenesis_Homo sapiens_hsa052040.82038117
87Arachidonic acid metabolism_Homo sapiens_hsa005900.82002221
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81431707
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80811621
90HIF-1 signaling pathway_Homo sapiens_hsa040660.80743601
91Peroxisome_Homo sapiens_hsa041460.79251391
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79200824
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77047988
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.75988554
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75777498
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75336242
97Retinol metabolism_Homo sapiens_hsa008300.73740864
98Salivary secretion_Homo sapiens_hsa049700.72151297
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72052375
100Ovarian steroidogenesis_Homo sapiens_hsa049130.71632078
101Fatty acid elongation_Homo sapiens_hsa000620.69393291
102Dopaminergic synapse_Homo sapiens_hsa047280.65740584
103Pyrimidine metabolism_Homo sapiens_hsa002400.65390885
104Purine metabolism_Homo sapiens_hsa002300.64929863
105Gastric acid secretion_Homo sapiens_hsa049710.62594329
106Vitamin digestion and absorption_Homo sapiens_hsa049770.59752783
107Insulin resistance_Homo sapiens_hsa049310.59118112
108Adherens junction_Homo sapiens_hsa045200.58841416
109PPAR signaling pathway_Homo sapiens_hsa033200.57624287
110beta-Alanine metabolism_Homo sapiens_hsa004100.57551305
111Axon guidance_Homo sapiens_hsa043600.54022847
112Glycerolipid metabolism_Homo sapiens_hsa005610.53853644
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53320072
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52404090
115Epstein-Barr virus infection_Homo sapiens_hsa051690.52241421
116Insulin signaling pathway_Homo sapiens_hsa049100.51572945
117AMPK signaling pathway_Homo sapiens_hsa041520.51408260
118Histidine metabolism_Homo sapiens_hsa003400.51316647
119One carbon pool by folate_Homo sapiens_hsa006700.49318528
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.49285587
121Focal adhesion_Homo sapiens_hsa045100.47790748
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.47191147
123Long-term depression_Homo sapiens_hsa047300.44913142
124p53 signaling pathway_Homo sapiens_hsa041150.43364799
125HTLV-I infection_Homo sapiens_hsa051660.43249408
126Cholinergic synapse_Homo sapiens_hsa047250.43002414
127Amphetamine addiction_Homo sapiens_hsa050310.41259100
128Herpes simplex infection_Homo sapiens_hsa051680.41159260
129TGF-beta signaling pathway_Homo sapiens_hsa043500.40403062
130Mineral absorption_Homo sapiens_hsa049780.40377747
131Oxytocin signaling pathway_Homo sapiens_hsa049210.39229776
132Small cell lung cancer_Homo sapiens_hsa052220.35578718
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35248238
134Notch signaling pathway_Homo sapiens_hsa043300.34986125
135ECM-receptor interaction_Homo sapiens_hsa045120.34873663
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.30711191
137Fructose and mannose metabolism_Homo sapiens_hsa000510.30701480
138MAPK signaling pathway_Homo sapiens_hsa040100.30236104
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30035829
140Collecting duct acid secretion_Homo sapiens_hsa049660.28925686
141mTOR signaling pathway_Homo sapiens_hsa041500.28755122
142Hippo signaling pathway_Homo sapiens_hsa043900.28564292
143Metabolic pathways_Homo sapiens_hsa011000.28396904
144Calcium signaling pathway_Homo sapiens_hsa040200.28289676
145Arginine and proline metabolism_Homo sapiens_hsa003300.26217915
146Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26138722
147Starch and sucrose metabolism_Homo sapiens_hsa005000.25475586
148Butanoate metabolism_Homo sapiens_hsa006500.25427638
149alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25001757
150Renin secretion_Homo sapiens_hsa049240.24966465
151Linoleic acid metabolism_Homo sapiens_hsa005910.24448421
152Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24125480
153Hedgehog signaling pathway_Homo sapiens_hsa043400.22635850
154Basal cell carcinoma_Homo sapiens_hsa052170.22353181
155Galactose metabolism_Homo sapiens_hsa000520.21493296
156Viral carcinogenesis_Homo sapiens_hsa052030.21289130
157Type II diabetes mellitus_Homo sapiens_hsa049300.20863195
158Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16540708
159Antigen processing and presentation_Homo sapiens_hsa046120.15154954
160Fat digestion and absorption_Homo sapiens_hsa049750.13951104
161MicroRNAs in cancer_Homo sapiens_hsa052060.13838771
162cAMP signaling pathway_Homo sapiens_hsa040240.12641760

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