MOXD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular copper ion homeostasis (GO:0006878)7.38054110
2hemidesmosome assembly (GO:0031581)6.26343467
3copper ion transport (GO:0006825)5.90023193
4tryptophan metabolic process (GO:0006568)5.89538951
5copper ion homeostasis (GO:0055070)5.66008357
6desmosome organization (GO:0002934)5.32644848
7regulation of somitogenesis (GO:0014807)5.31719976
8L-phenylalanine catabolic process (GO:0006559)5.31015622
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.31015622
10protein heterotrimerization (GO:0070208)5.28959481
11L-phenylalanine metabolic process (GO:0006558)4.89844318
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.89844318
13tyrosine metabolic process (GO:0006570)4.86975356
14transepithelial transport (GO:0070633)4.71942717
15kynurenine metabolic process (GO:0070189)4.65205533
16indole-containing compound catabolic process (GO:0042436)4.61158504
17indolalkylamine catabolic process (GO:0046218)4.61158504
18tryptophan catabolic process (GO:0006569)4.61158504
19adenosine metabolic process (GO:0046085)4.53256926
20aromatic amino acid family catabolic process (GO:0009074)4.45260189
21regulation of protein activation cascade (GO:2000257)4.44019927
22bile acid biosynthetic process (GO:0006699)4.43751077
23extracellular matrix assembly (GO:0085029)4.36819547
24indolalkylamine metabolic process (GO:0006586)4.30586623
25cerebral cortex radially oriented cell migration (GO:0021799)4.29068551
26regulation of complement activation (GO:0030449)4.26254348
27axon extension involved in axon guidance (GO:0048846)4.25174797
28neuron projection extension involved in neuron projection guidance (GO:1902284)4.25174797
29protein carboxylation (GO:0018214)4.19777889
30peptidyl-glutamic acid carboxylation (GO:0017187)4.19777889
31ethanol oxidation (GO:0006069)4.04818405
32multicellular organismal water homeostasis (GO:0050891)3.97374307
33pyrimidine nucleoside catabolic process (GO:0046135)3.97060090
34postsynaptic membrane organization (GO:0001941)3.95672835
35complement activation, alternative pathway (GO:0006957)3.95084530
36bone trabecula formation (GO:0060346)3.91023723
37regulation of fibrinolysis (GO:0051917)3.83746669
38fibrinolysis (GO:0042730)3.81096965
39glyoxylate metabolic process (GO:0046487)3.79070965
40negative regulation of smooth muscle cell migration (GO:0014912)3.76873016
41aromatic amino acid family metabolic process (GO:0009072)3.74471515
42outer ear morphogenesis (GO:0042473)3.67686116
43dermatan sulfate biosynthetic process (GO:0030208)3.67646646
44primary alcohol catabolic process (GO:0034310)3.67535991
45negative regulation of osteoblast proliferation (GO:0033689)3.66419263
46negative regulation of fibrinolysis (GO:0051918)3.65717360
47cellular glucuronidation (GO:0052695)3.61401308
48water homeostasis (GO:0030104)3.60454534
49negative regulation of leukocyte chemotaxis (GO:0002689)3.56336491
50sequestering of extracellular ligand from receptor (GO:0035581)3.55136221
51dermatan sulfate metabolic process (GO:0030205)3.54779137
52mesenchymal-epithelial cell signaling (GO:0060638)3.52330015
53cell migration involved in sprouting angiogenesis (GO:0002042)3.52049351
54layer formation in cerebral cortex (GO:0021819)3.50918922
55presynaptic membrane assembly (GO:0097105)3.50391804
56regulation of chemokine-mediated signaling pathway (GO:0070099)3.48673917
57cytolysis (GO:0019835)3.47316295
58axon extension (GO:0048675)3.46194735
59blood vessel maturation (GO:0001955)3.46084062
60establishment of planar polarity (GO:0001736)3.45515423
61establishment of tissue polarity (GO:0007164)3.45515423
62high-density lipoprotein particle remodeling (GO:0034375)3.44079198
63sodium ion homeostasis (GO:0055078)3.39255661
64calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.38712092
65cell migration involved in heart development (GO:0060973)3.38285013
66olfactory bulb development (GO:0021772)3.37683519
67response to nitrosative stress (GO:0051409)3.30238357
68cochlea morphogenesis (GO:0090103)3.30235840
69bile acid metabolic process (GO:0008206)3.29091626
70axonal fasciculation (GO:0007413)3.25109354
71triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.24453101
72keratinocyte proliferation (GO:0043616)3.24262048
73skin morphogenesis (GO:0043589)3.23446471
74negative regulation of axon guidance (GO:1902668)3.22619674
75negative chemotaxis (GO:0050919)3.21788480
76urea metabolic process (GO:0019627)3.20836521
77urea cycle (GO:0000050)3.20836521
78kidney mesenchyme development (GO:0072074)3.19227798
79iron ion import (GO:0097286)3.18971096
80regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.18555655
81regulation of phospholipase A2 activity (GO:0032429)3.17826783
82indole-containing compound metabolic process (GO:0042430)3.16509137
83glial cell migration (GO:0008347)3.15279941
84metanephric mesenchyme development (GO:0072075)3.15042253
85ethanol metabolic process (GO:0006067)3.14675795
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.14414884
87uronic acid metabolic process (GO:0006063)3.13345888
88glucuronate metabolic process (GO:0019585)3.13345888
89regulation of plasminogen activation (GO:0010755)3.12737726
90regulation of development, heterochronic (GO:0040034)3.12321963
91tongue development (GO:0043586)3.08069785
92bundle of His cell to Purkinje myocyte communication (GO:0086069)3.07996052
93aldehyde catabolic process (GO:0046185)3.07741209
94sulfur amino acid catabolic process (GO:0000098)3.07250896
95complement activation, classical pathway (GO:0006958)3.07061321
96coenzyme catabolic process (GO:0009109)3.06303068
97negative regulation of chondrocyte differentiation (GO:0032331)3.05984533
98embryonic skeletal joint morphogenesis (GO:0060272)3.05738013
99regulation of metalloenzyme activity (GO:0048552)3.04992840
100lens morphogenesis in camera-type eye (GO:0002089)3.04481810
101cellular modified amino acid catabolic process (GO:0042219)3.03992709
102cellular response to vitamin (GO:0071295)3.03510965
103fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.00865161
104cellular zinc ion homeostasis (GO:0006882)3.00822036
105retinal ganglion cell axon guidance (GO:0031290)3.00321493
106glomerular basement membrane development (GO:0032836)2.99503337
107regulation of bile acid biosynthetic process (GO:0070857)2.99264524
108positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.99187629
109chondrocyte proliferation (GO:0035988)2.99043946
110reverse cholesterol transport (GO:0043691)2.97409254
111positive regulation of embryonic development (GO:0040019)2.97099361
112collagen metabolic process (GO:0032963)2.95513453
113excretion (GO:0007588)2.95089854
114negative regulation of protein activation cascade (GO:2000258)2.94992482
115collagen fibril organization (GO:0030199)2.92692349
116triglyceride homeostasis (GO:0070328)2.91980950
117acylglycerol homeostasis (GO:0055090)2.91980950
118Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.91672170
119positive regulation of neuroblast proliferation (GO:0002052)2.91096697
120establishment of skin barrier (GO:0061436)2.90967861
121keratan sulfate catabolic process (GO:0042340)2.90944248
122phospholipid efflux (GO:0033700)2.90278876
123cellular response to vitamin D (GO:0071305)2.90253149
124protein retention in ER lumen (GO:0006621)2.90205073
125regulation of establishment of planar polarity (GO:0090175)2.89774637
126G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.89512706
127central nervous system projection neuron axonogenesis (GO:0021952)2.89371904
128amine catabolic process (GO:0009310)2.87916225
129cellular biogenic amine catabolic process (GO:0042402)2.87916225
130neuron recognition (GO:0008038)2.87540173
131complement activation (GO:0006956)2.87352184
132collagen catabolic process (GO:0030574)2.87083394
133neuron projection extension (GO:1990138)2.86004668
134regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.85838263
135cerebral cortex cell migration (GO:0021795)2.85811346
136negative regulation of hemostasis (GO:1900047)2.85267849
137negative regulation of blood coagulation (GO:0030195)2.85267849
138negative regulation of wound healing (GO:0061045)2.84073368
139extracellular fibril organization (GO:0043206)2.84067454
140nonmotile primary cilium assembly (GO:0035058)2.83822068
141regulation of neuroblast proliferation (GO:1902692)2.83387496
142nitrogen cycle metabolic process (GO:0071941)2.83334995
143cholesterol biosynthetic process (GO:0006695)2.82858305
144paraxial mesoderm development (GO:0048339)2.82278060
145positive regulation of smoothened signaling pathway (GO:0045880)2.81256086
146regulation of triglyceride catabolic process (GO:0010896)2.81147527
147organ induction (GO:0001759)2.81002343
148negative regulation of coagulation (GO:0050819)2.80470949
149alpha-linolenic acid metabolic process (GO:0036109)2.79302523
150presynaptic membrane organization (GO:0097090)2.77487897
151cysteine metabolic process (GO:0006534)2.77382096
152negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.76921643
153cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.76613540
154lysine metabolic process (GO:0006553)2.75855313
155lysine catabolic process (GO:0006554)2.75855313
156type B pancreatic cell proliferation (GO:0044342)2.75625841
157notochord development (GO:0030903)2.75005465
158negative regulation of smoothened signaling pathway (GO:0045879)2.74933568
159convergent extension (GO:0060026)2.74567937
160endodermal cell differentiation (GO:0035987)2.74171458
161regulation of timing of cell differentiation (GO:0048505)2.73933033
162negative regulation of protein localization to cell surface (GO:2000009)2.73737690
163axis elongation (GO:0003401)2.73551536
164regulation of axon guidance (GO:1902667)2.73053702
165regulation of cell fate specification (GO:0042659)2.72333673
166positive regulation of synapse assembly (GO:0051965)2.71971425
167amino-acid betaine metabolic process (GO:0006577)2.71574627
168regulation of respiratory system process (GO:0044065)2.70993490
169multicellular organismal macromolecule metabolic process (GO:0044259)2.70583681
170neural crest cell development (GO:0014032)2.69409441
171regulation of water loss via skin (GO:0033561)2.69235868
172virion attachment to host cell (GO:0019062)2.67916053
173adhesion of symbiont to host cell (GO:0044650)2.67916053
174radial glial cell differentiation (GO:0060019)2.67314358
175maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.66473357
176cholesterol transport (GO:0030301)2.66260246
177sterol transport (GO:0015918)2.66260246
178protein-lipid complex remodeling (GO:0034368)2.64783829
179macromolecular complex remodeling (GO:0034367)2.64783829
180plasma lipoprotein particle remodeling (GO:0034369)2.64783829
181developmental growth involved in morphogenesis (GO:0060560)2.64568749
182sperm capacitation (GO:0048240)2.64565722
183cranial nerve morphogenesis (GO:0021602)2.64085816
184protein activation cascade (GO:0072376)2.63507588
185benzene-containing compound metabolic process (GO:0042537)2.62759242
186chondroitin sulfate catabolic process (GO:0030207)2.62582891
187planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61580732
188negative regulation of fibroblast apoptotic process (GO:2000270)2.61171633
189multicellular organismal catabolic process (GO:0044243)2.59272011
190positive regulation of mitochondrial fission (GO:0090141)2.58835344
191regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.58644616
192lens fiber cell development (GO:0070307)2.58205847
193branch elongation of an epithelium (GO:0060602)2.58133825
194ephrin receptor signaling pathway (GO:0048013)2.57376974
195regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.56873480
196heparan sulfate proteoglycan metabolic process (GO:0030201)2.56575372

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.85342910
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.25009335
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.64303712
4EZH2_22144423_ChIP-Seq_EOC_Human4.24142594
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.63132493
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.56325212
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.40464934
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.11113321
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.07075243
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.93692023
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.90044336
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.80784400
13* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.79796119
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.68241177
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.52663838
16GBX2_23144817_ChIP-Seq_PC3_Human2.51399808
17* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.31667225
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.22928076
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21817142
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13092957
21AR_21572438_ChIP-Seq_LNCaP_Human2.05277216
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.04388102
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.04089302
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.00503910
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.95863682
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.93644973
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.91011575
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.84948392
29* BRD4_25478319_ChIP-Seq_HGPS_Human1.78826365
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78679068
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.71401791
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.61827667
33IGF1R_20145208_ChIP-Seq_DFB_Human1.57816997
34* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55985476
35EGR1_19032775_ChIP-ChIP_M12_Human1.54803428
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51800735
37* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50882890
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48893905
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48459892
40SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.48419366
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45938181
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45790258
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45597320
44P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44310966
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.42829557
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.42498860
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42320728
48SOX2_20726797_ChIP-Seq_SW620_Human1.41484381
49CJUN_26792858_Chip-Seq_BT549_Human1.41447587
50* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40279124
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40256434
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39736915
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.37322358
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36715703
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.35373160
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35220880
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35220880
58ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33484147
59SMAD4_21799915_ChIP-Seq_A2780_Human1.33479848
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33452519
61* RING1B_27294783_Chip-Seq_ESCs_Mouse1.32012272
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.29064529
63* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27261366
64KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27159881
65* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.27102390
66* ISL1_27105846_Chip-Seq_CPCs_Mouse1.26834920
67P300_19829295_ChIP-Seq_ESCs_Human1.26079880
68FUS_26573619_Chip-Seq_HEK293_Human1.25500925
69* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24504058
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22729341
71* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21870914
72TP53_16413492_ChIP-PET_HCT116_Human1.21538957
73TP53_18474530_ChIP-ChIP_U2OS_Human1.21215760
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.20944361
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20754903
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20754903
77* CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20295930
78KDM2B_26808549_Chip-Seq_REH_Human1.19187197
79ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19181247
80* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19036601
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17494713
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17207236
83SA1_22415368_ChIP-Seq_MEFs_Mouse1.17192558
84EZH2_27304074_Chip-Seq_ESCs_Mouse1.17068006
85JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16863706
86* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16347940
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15590163
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14544898
89SOX9_26525672_Chip-Seq_HEART_Mouse1.13609831
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13328363
91TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12800012
92TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12678604
93AHR_22903824_ChIP-Seq_MCF-7_Human1.12551421
94* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09821665
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09646016
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09019805
97TP53_20018659_ChIP-ChIP_R1E_Mouse1.08983530
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08573671
99FOXA2_19822575_ChIP-Seq_HepG2_Human1.08556179
100CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07386015
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06252984
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05777922
103RNF2_27304074_Chip-Seq_NSC_Mouse1.04989249
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04547625
105* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03631208
106CLOCK_20551151_ChIP-Seq_293T_Human1.03551718
107* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02081014
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.00859713
109SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00556984
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00556984
111TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99240443
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99121221
113FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98588137
114JUN_21703547_ChIP-Seq_K562_Human0.98229388
115* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97784526
116* EZH2_27294783_Chip-Seq_NPCs_Mouse0.97574030
117PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96240230
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95436026
119TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95083098
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94905808
121STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94892310
122POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94534471
123IRF1_19129219_ChIP-ChIP_H3396_Human0.93897328
124RNF2_27304074_Chip-Seq_ESCs_Mouse0.93130003
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92420262
126* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91951992
127TP63_23658742_ChIP-Seq_EP156T_Human0.91744796
128BCAT_22108803_ChIP-Seq_LS180_Human0.91088787
129TAF15_26573619_Chip-Seq_HEK293_Human0.91059363
130PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89544435
131* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88631825
132CDX2_20551321_ChIP-Seq_CACO-2_Human0.87615147
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.86028717
134* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85050408
135CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84021250
136TCF4_22108803_ChIP-Seq_LS180_Human0.83390937
137TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82288645
138CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.81735496
139BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81157166
140RACK7_27058665_Chip-Seq_MCF-7_Human0.80903061
141* EZH2_27294783_Chip-Seq_ESCs_Mouse0.80527654
142GATA3_24758297_ChIP-Seq_MCF-7_Human0.79966525
143SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79366795
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78086046
145HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78038762
146SMAD3_21741376_ChIP-Seq_HESCs_Human0.78032882
147EP300_21415370_ChIP-Seq_HL-1_Mouse0.77214837
148WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76109695
149MYC_27129775_Chip-Seq_CORNEA_Mouse0.75920310
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74076029
151ESR1_15608294_ChIP-ChIP_MCF-7_Human0.73606147
152PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73265200
153CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73162609
154KLF5_25053715_ChIP-Seq_YYC3_Human0.72667625
155RXR_22108803_ChIP-Seq_LS180_Human0.72581026
156AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72406076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology4.01114743
2MP0005275_abnormal_skin_tensile3.99886923
3MP0001958_emphysema3.83241364
4MP0002139_abnormal_hepatobiliary_system3.70213999
5MP0006054_spinal_hemorrhage3.68085114
6MP0002163_abnormal_gland_morphology3.46742895
7MP0004885_abnormal_endolymph3.30790096
8MP0005360_urolithiasis3.26497063
9MP0002132_abnormal_respiratory_system2.99287172
10MP0005085_abnormal_gallbladder_physiolo2.85567075
11MP0010234_abnormal_vibrissa_follicle2.69324207
12MP0005257_abnormal_intraocular_pressure2.65972046
13MP0003300_gastrointestinal_ulcer2.60681291
14MP0003705_abnormal_hypodermis_morpholog2.49284982
15MP0003941_abnormal_skin_development2.45546126
16MP0002060_abnormal_skin_morphology2.43813060
17MP0002796_impaired_skin_barrier2.41468570
18MP0006292_abnormal_olfactory_placode2.35689678
19MP0008438_abnormal_cutaneous_collagen2.35526859
20MP0002098_abnormal_vibrissa_morphology2.30619323
21MP0003806_abnormal_nucleotide_metabolis2.24364572
22MP0002254_reproductive_system_inflammat2.19757144
23MP0000049_abnormal_middle_ear2.14609360
24MP0005365_abnormal_bile_salt2.11308925
25MP0005408_hypopigmentation2.11106003
26MP0000579_abnormal_nail_morphology2.10432636
27MP0003122_maternal_imprinting2.09889113
28MP0009697_abnormal_copulation1.95298568
29MP0001177_atelectasis1.94651397
30MP0000462_abnormal_digestive_system1.92524391
31MP0002277_abnormal_respiratory_mucosa1.90774409
32MP0005379_endocrine/exocrine_gland_phen1.88923920
33MP0005171_absent_coat_pigmentation1.88920296
34MP0000778_abnormal_nervous_system1.85042580
35MP0001299_abnormal_eye_distance/1.83632245
36MP0001529_abnormal_vocalization1.81959199
37MP0000762_abnormal_tongue_morphology1.75800417
38MP0008875_abnormal_xenobiotic_pharmacok1.73314435
39MP0005623_abnormal_meninges_morphology1.70392204
40MP0004272_abnormal_basement_membrane1.67701744
41MP0009053_abnormal_anal_canal1.64420019
42MP0003252_abnormal_bile_duct1.63560623
43MP0000427_abnormal_hair_cycle1.60907204
44MP0000383_abnormal_hair_follicle1.57466942
45MP0003195_calcinosis1.53011236
46MP0001542_abnormal_bone_strength1.50521949
47MP0000428_abnormal_craniofacial_morphol1.50399636
48MP0002089_abnormal_postnatal_growth/wei1.49955638
49MP0010678_abnormal_skin_adnexa1.49552913
50MP0001270_distended_abdomen1.48852132
51MP0002933_joint_inflammation1.47715820
52MP0002233_abnormal_nose_morphology1.47057960
53MP0010771_integument_phenotype1.41682378
54MP0002282_abnormal_trachea_morphology1.40405352
55MP0005394_taste/olfaction_phenotype1.39920035
56MP0005499_abnormal_olfactory_system1.39920035
57MP0000751_myopathy1.39880546
58MP0000372_irregular_coat_pigmentation1.39751089
59MP0003566_abnormal_cell_adhesion1.39633301
60MP0005501_abnormal_skin_physiology1.39417262
61MP0003453_abnormal_keratinocyte_physiol1.38314071
62MP0000647_abnormal_sebaceous_gland1.37493199
63MP0005508_abnormal_skeleton_morphology1.35289069
64MP0004381_abnormal_hair_follicle1.34760218
65MP0009250_abnormal_appendicular_skeleto1.33600540
66MP0003937_abnormal_limbs/digits/tail_de1.32306525
67MP0001216_abnormal_epidermal_layer1.29608636
68MP0000613_abnormal_salivary_gland1.26698370
69MP0010329_abnormal_lipoprotein_level1.26358822
70MP0000377_abnormal_hair_follicle1.23163199
71MP0002108_abnormal_muscle_morphology1.22494657
72MP0000767_abnormal_smooth_muscle1.20602343
73MP0003385_abnormal_body_wall1.19940379
74MP0002249_abnormal_larynx_morphology1.19325089
75MP0005248_abnormal_Harderian_gland1.17684385
76MP0002168_other_aberrant_phenotype1.17521751
77MP0000467_abnormal_esophagus_morphology1.16881950
78MP0001984_abnormal_olfaction1.16094091
79MP0000163_abnormal_cartilage_morphology1.16020376
80MP0000566_synostosis1.15538888
81MP0005220_abnormal_exocrine_pancreas1.13232178
82MP0010030_abnormal_orbit_morphology1.11085427
83MP0001340_abnormal_eyelid_morphology1.08228094
84MP0004859_abnormal_synaptic_plasticity1.07065716
85MP0000537_abnormal_urethra_morphology1.06987548
86MP0002092_abnormal_eye_morphology1.05709296
87MP0002653_abnormal_ependyma_morphology1.04733866
88MP0002938_white_spotting1.04347593
89MP0002116_abnormal_craniofacial_bone1.03451278
90MP0005023_abnormal_wound_healing1.02681941
91MP0003283_abnormal_digestive_organ1.02521530
92MP0001756_abnormal_urination1.02143523
93MP0004019_abnormal_vitamin_homeostasis1.00778154
94MP0003329_amyloid_beta_deposits1.00212627
95MP0008789_abnormal_olfactory_epithelium1.00122795
96MP0009384_cardiac_valve_regurgitation0.99092570
97MP0001849_ear_inflammation0.96960693
98MP0004134_abnormal_chest_morphology0.95575929
99MP0001666_abnormal_nutrient_absorption0.93710816
100MP0008872_abnormal_physiological_respon0.93569593
101MP0003091_abnormal_cell_migration0.92995568
102MP0001243_abnormal_dermal_layer0.92393674
103MP0000026_abnormal_inner_ear0.90962719
104MP0000432_abnormal_head_morphology0.90545377
105MP0003942_abnormal_urinary_system0.90447549
106MP0004133_heterotaxia0.90446044
107MP0003115_abnormal_respiratory_system0.89239409
108MP0006072_abnormal_retinal_apoptosis0.88748964
109MP0002932_abnormal_joint_morphology0.88405497
110MP0001293_anophthalmia0.87891191
111MP0002115_abnormal_skeleton_extremities0.87828321
112MP0001851_eye_inflammation0.86780218
113MP0002133_abnormal_respiratory_system0.86646066
114MP0005388_respiratory_system_phenotype0.86646066
115MP0002177_abnormal_outer_ear0.85516899
116MP0010386_abnormal_urinary_bladder0.85273444
117MP0005187_abnormal_penis_morphology0.85085108
118MP0009379_abnormal_foot_pigmentation0.84802272
119MP0005395_other_phenotype0.84247139
120MP0001485_abnormal_pinna_reflex0.83775414
121MP0005197_abnormal_uvea_morphology0.83317214
122MP0002697_abnormal_eye_size0.82521939
123MP0003136_yellow_coat_color0.82224697
124MP0002009_preneoplasia0.81682908
125MP0009840_abnormal_foam_cell0.80673479
126MP0002090_abnormal_vision0.78494819
127MP0002234_abnormal_pharynx_morphology0.77792942
128MP0003279_aneurysm0.77639680
129MP0010368_abnormal_lymphatic_system0.77594288
130MP0000750_abnormal_muscle_regeneration0.77077734
131MP0002751_abnormal_autonomic_nervous0.76833543
132MP0001346_abnormal_lacrimal_gland0.76109893
133MP0005332_abnormal_amino_acid0.74997342
134MP0000534_abnormal_ureter_morphology0.74889512
135MP0000569_abnormal_digit_pigmentation0.74290353
136MP0005647_abnormal_sex_gland0.74278815
137MP0005391_vision/eye_phenotype0.73839317
138MP0005595_abnormal_vascular_smooth0.72665911
139MP0003935_abnormal_craniofacial_develop0.72040191
140MP0003755_abnormal_palate_morphology0.71122350
141MP0005253_abnormal_eye_physiology0.71025536
142MP0009931_abnormal_skin_appearance0.70995402
143MP0004858_abnormal_nervous_system0.70953372
144MP0000538_abnormal_urinary_bladder0.70922912
145MP0002295_abnormal_pulmonary_circulatio0.70669605
146MP0002109_abnormal_limb_morphology0.69008765
147MP0002114_abnormal_axial_skeleton0.68854607
148MP0009643_abnormal_urine_homeostasis0.68823915
149MP0002896_abnormal_bone_mineralization0.68531216
150MP0003938_abnormal_ear_development0.67261793
151MP0000604_amyloidosis0.65977852
152MP0009780_abnormal_chondrocyte_physiolo0.65976905
153MP0001286_abnormal_eye_development0.65871418
154MP0001879_abnormal_lymphatic_vessel0.63764479

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cochlea (HP:0000375)8.21985151
2Hypokalemic alkalosis (HP:0001949)6.24395976
3Abnormality of chloride homeostasis (HP:0011422)5.89513306
4Premature rupture of membranes (HP:0001788)5.81071893
5Morphological abnormality of the inner ear (HP:0011390)5.79517695
6Hyperactive renin-angiotensin system (HP:0000841)5.76295847
7Protrusio acetabuli (HP:0003179)5.64037668
8Ileus (HP:0002595)5.36273155
9Abnormality of the right ventricle (HP:0001707)4.91925173
10Conjugated hyperbilirubinemia (HP:0002908)4.91184051
11Renal salt wasting (HP:0000127)4.79281598
12Hyperaldosteronism (HP:0000859)4.77633596
13Rectal prolapse (HP:0002035)4.45468812
14Chronic bronchitis (HP:0004469)4.40514989
15Follicular hyperkeratosis (HP:0007502)4.07187531
16Vascular calcification (HP:0004934)4.05542627
17Soft skin (HP:0000977)3.95398848
18Ankle contracture (HP:0006466)3.93063575
19Vitreoretinal degeneration (HP:0000655)3.91304777
20Decreased circulating renin level (HP:0003351)3.90008072
21Bladder diverticulum (HP:0000015)3.89416780
22Aortic aneurysm (HP:0004942)3.79376673
23Abnormality of dentin (HP:0010299)3.77008788
24Hyperkalemia (HP:0002153)3.75903901
25Aortic dissection (HP:0002647)3.72722713
26Male infertility (HP:0003251)3.72589364
27Cardiovascular calcification (HP:0011915)3.70192671
28Alkalosis (HP:0001948)3.65952058
29Hyponatremia (HP:0002902)3.56234634
30Epiphyseal dysplasia (HP:0002656)3.54422078
31Deep venous thrombosis (HP:0002625)3.49399369
32Cervical subluxation (HP:0003308)3.45891182
33Broad metatarsal (HP:0001783)3.43691375
34Intrahepatic cholestasis (HP:0001406)3.37239411
35Complement deficiency (HP:0004431)3.32490907
36Fragile nails (HP:0001808)3.28286881
37Coronal craniosynostosis (HP:0004440)3.16360867
38Shallow orbits (HP:0000586)3.13226711
39Onycholysis (HP:0001806)3.00842206
40Wormian bones (HP:0002645)2.99826452
41Abnormality of sodium homeostasis (HP:0010931)2.99507624
42Woolly hair (HP:0002224)2.81153756
43Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.79219034
44Short 4th metacarpal (HP:0010044)2.79219034
45Biconcave vertebral bodies (HP:0004586)2.79089818
46Atrophic scars (HP:0001075)2.78399944
47Wide anterior fontanel (HP:0000260)2.74243971
48Abnormality of the phalanges of the hallux (HP:0010057)2.73865031
49Milia (HP:0001056)2.70089282
50Xanthomatosis (HP:0000991)2.69149872
51Genu recurvatum (HP:0002816)2.68691876
52Azoospermia (HP:0000027)2.67504549
53Type 1 muscle fiber predominance (HP:0003803)2.67342940
54Bowel diverticulosis (HP:0005222)2.63136818
55Metabolic alkalosis (HP:0200114)2.60294980
56Arterial tortuosity (HP:0005116)2.60221969
57Spinal rigidity (HP:0003306)2.59390874
58Mitral regurgitation (HP:0001653)2.56425869
59Right ventricular cardiomyopathy (HP:0011663)2.52023412
60Abnormality of complement system (HP:0005339)2.49385603
61Slender build (HP:0001533)2.49105886
62Prolonged partial thromboplastin time (HP:0003645)2.48322054
63Hypokalemia (HP:0002900)2.48233963
64Vertebral compression fractures (HP:0002953)2.47537434
65Joint laxity (HP:0001388)2.45855584
66Plantar hyperkeratosis (HP:0007556)2.45715736
67Hypoplastic ischia (HP:0003175)2.45056898
68Lip pit (HP:0100267)2.43008128
69Hyperlipoproteinemia (HP:0010980)2.42863732
70Abnormality of monocarboxylic acid metabolism (HP:0010996)2.42061874
71Microglossia (HP:0000171)2.39630979
72Osteomalacia (HP:0002749)2.38459003
73Natal tooth (HP:0000695)2.38423917
74Abnormality of aromatic amino acid family metabolism (HP:0004338)2.36726303
75Absent frontal sinuses (HP:0002688)2.35049625
76Abnormality of the ischium (HP:0003174)2.34088339
77Hypothermia (HP:0002045)2.31522270
78Broad long bones (HP:0005622)2.31231364
79Hypoplasia of the iris (HP:0007676)2.30748015
80Mild short stature (HP:0003502)2.30611805
81Aortic regurgitation (HP:0001659)2.28662798
82Exostoses (HP:0100777)2.28009694
83Spinal muscular atrophy (HP:0007269)2.25561567
84Vascular tortuosity (HP:0004948)2.24501113
85Turricephaly (HP:0000262)2.22911478
86Keratoconus (HP:0000563)2.19703854
87Increased corneal curvature (HP:0100692)2.19703854
88Enlarged epiphyses (HP:0010580)2.18920962
89Dehydration (HP:0001944)2.18701906
90Camptodactyly of toe (HP:0001836)2.17327160
91Adrenal overactivity (HP:0002717)2.14791723
92Abnormality of the 4th metacarpal (HP:0010012)2.14047951
93Pulmonary artery stenosis (HP:0004415)2.11806500
94Hyperextensible skin (HP:0000974)2.11655973
95Morphological abnormality of the middle ear (HP:0008609)2.10410783
96Abnormality of the phalanges of the 2nd finger (HP:0009541)2.09229916
97Osteoarthritis (HP:0002758)2.06712221
98Hypotrichosis (HP:0001006)2.06269468
99Overgrowth (HP:0001548)2.05655365
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05417324
101Irregular epiphyses (HP:0010582)2.05208070
102Dilatation of the ascending aorta (HP:0005111)2.05039153
103Breech presentation (HP:0001623)2.04602128
104Abnormality of potassium homeostasis (HP:0011042)2.01816777
105Blue sclerae (HP:0000592)2.01667766
106Abnormality of the middle phalanges of the toes (HP:0010183)2.01369594
107Hypoventilation (HP:0002791)1.99962048
108Broad phalanx (HP:0006009)1.99856078
109Tarsal synostosis (HP:0008368)1.98724111
110Ulnar bowing (HP:0003031)1.98340448
111Abnormality of the 2nd finger (HP:0004100)1.98303417
112Fragile skin (HP:0001030)1.98170589
113Humeroradial synostosis (HP:0003041)1.97816383
114Synostosis involving the elbow (HP:0003938)1.97816383
115Hypobetalipoproteinemia (HP:0003563)1.97224966
116Mildly elevated creatine phosphokinase (HP:0008180)1.95476606
117Down-sloping shoulders (HP:0200021)1.94126679
118Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.93839865
119Abnormality of the common coagulation pathway (HP:0010990)1.93765898
120Preaxial foot polydactyly (HP:0001841)1.93596020
121Abnormality of renin-angiotensin system (HP:0000847)1.93354867
122Esophageal varix (HP:0002040)1.92366994
123Flat acetabular roof (HP:0003180)1.92303120
124Neonatal short-limb short stature (HP:0008921)1.91293624
125Abnormality of skull ossification (HP:0002703)1.91229437
126Amyloidosis (HP:0011034)1.89783321
127Infantile muscular hypotonia (HP:0008947)1.89295293
128Broad foot (HP:0001769)1.88191255
129Metabolic acidosis (HP:0001942)1.87837275
130Severe Myopia (HP:0011003)1.87674154
131Broad ribs (HP:0000885)1.87377404
132Abnormality of the acetabulum (HP:0003170)1.86913193
133Ectopia lentis (HP:0001083)1.86848267
134Hydroureter (HP:0000072)1.85068013
135Limited hip movement (HP:0008800)1.84920179
136Mesomelia (HP:0003027)1.83951954
137Exocrine pancreatic insufficiency (HP:0001738)1.83877378
138Inguinal hernia (HP:0000023)1.83487659
139Decreased skull ossification (HP:0004331)1.82627132
140Congenital primary aphakia (HP:0007707)1.82564180
141Long toe (HP:0010511)1.81012497
142Recurrent corneal erosions (HP:0000495)1.80884719
143Deviation of the hallux (HP:0010051)1.80482377
144Protuberant abdomen (HP:0001538)1.80347986
145Peritonitis (HP:0002586)1.80317527
146Chondrocalcinosis (HP:0000934)1.79438823
147Broad finger (HP:0001500)1.79391449
148Gait imbalance (HP:0002141)1.79091428
149Increased variability in muscle fiber diameter (HP:0003557)1.79065896
150Abnormality of the diencephalon (HP:0010662)1.79042161
151Mitral valve prolapse (HP:0001634)1.77459244
152Abnormality of Sharpey fibers (HP:0100685)1.75832170
153Synostosis involving bones of the lower limbs (HP:0009138)1.75741764
154Synostosis involving bones of the feet (HP:0009140)1.75741764
155Distal lower limb muscle weakness (HP:0009053)1.75677532
156Tracheal stenosis (HP:0002777)1.75603774
157Abnormal tarsal ossification (HP:0008369)1.75426339
158Aplasia cutis congenita (HP:0001057)1.74313295
159Aplasia/Hypoplasia of the tongue (HP:0010295)1.74136881
160Wrist flexion contracture (HP:0001239)1.74067837
161Broad phalanges of the hand (HP:0009768)1.73782732
162Postaxial foot polydactyly (HP:0001830)1.73504732
163Postaxial hand polydactyly (HP:0001162)1.73102123
164Aortic valve stenosis (HP:0001650)1.72373955
165Osteopenia (HP:0000938)1.71718763
166Narrow nasal bridge (HP:0000446)1.71316053
167Fibular hypoplasia (HP:0003038)1.69362576
168Abnormal delivery (HP:0001787)1.69121659
169Limb-girdle muscle weakness (HP:0003325)1.68861903
170Broad toe (HP:0001837)1.68558868
171Hypercalciuria (HP:0002150)1.67375807
172Protruding ear (HP:0000411)1.66573098
173Cupped ribs (HP:0000887)1.66277752
174Micromelia (HP:0002983)1.65478683
175Broad palm (HP:0001169)1.65007257
176Epidermoid cyst (HP:0200040)1.63726191
177Hallux valgus (HP:0001822)1.63621264
178Abnormality of the phalanges of the 5th finger (HP:0004213)1.63223277
179Renal duplication (HP:0000075)1.62898013
180Aplasia of the phalanges of the hand (HP:0009802)1.62282281
181Aplasia involving bones of the extremities (HP:0009825)1.62282281
182Aplasia involving bones of the upper limbs (HP:0009823)1.62282281
183Abnormal spermatogenesis (HP:0008669)1.61843592
184Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.61663975
185Mixed hearing impairment (HP:0000410)1.60910197
186Alopecia of scalp (HP:0002293)1.60717237
187Mitral stenosis (HP:0001718)1.60398010
188Hypolipoproteinemia (HP:0010981)1.59964783
189Nephrogenic diabetes insipidus (HP:0009806)1.59724339
190Aplasia/Hypoplasia of the fibula (HP:0006492)1.59239344
191Arthropathy (HP:0003040)1.57861247
192Fat malabsorption (HP:0002630)1.56728937
193Hepatitis (HP:0012115)1.56624223

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKG23.79330968
2NEK93.74081587
3MAP3K33.16035102
4ERN13.03329642
5PRKD32.91978575
6LIMK12.69427388
7MYLK2.49041923
8LATS12.25661702
9MAP4K22.22249483
10PAK62.12759658
11LMTK213.2709354
12MARK11.99146864
13FRK1.91343941
14MST1R1.90768747
15PRKD21.86904720
16DDR21.69399478
17TESK11.64088214
18MOS1.62746496
19STK38L1.62266985
20CSNK1A1L1.55665438
21PAK21.53894126
22CASK1.50928239
23MKNK11.46077835
24MAP3K21.45120128
25EPHA41.43654798
26RPS6KA41.40409303
27NTRK21.35648844
28CSNK1G31.35352689
29AKT31.32622389
30WEE11.30457031
31CDK191.28794213
32DYRK31.27824099
33SIK11.25598718
34PAK31.23513624
35ERBB31.22354338
36FGFR41.20951421
37EPHB21.19135188
38TAOK11.18547662
39PAK41.16782603
40FER1.16483721
41CSNK1G11.15851866
42ERBB21.15583638
43LATS21.14901191
44MAPKAPK31.10558144
45BRSK21.09087060
46FGFR21.04409536
47WNK31.02913416
48ROCK11.02450132
49RIPK11.00657862
50MET0.98471055
51TAOK20.96242888
52TRIM280.95328381
53MAP2K30.91741765
54STK240.88119846
55EPHA30.86023493
56CDK180.84742308
57ADRBK10.84706589
58CDK11A0.84544854
59CDK140.83229020
60CDK150.81057202
61DYRK20.79223366
62ERBB40.76995479
63BCKDK0.75405985
64MKNK20.71701807
65TRPM70.71554799
66PDGFRB0.70192918
67PTK60.70165465
68BRSK10.70074741
69RPS6KB20.68346889
70EPHB10.68300121
71CDK60.67785435
72UHMK10.67556999
73TRIB30.66588249
74FGFR30.65596426
75BMPR1B0.65366887
76PTK20.63150530
77PIK3CG0.62761489
78MAP2K10.60846595
79SIK30.58505441
80MAP3K110.58045809
81MAP2K40.58007904
82DMPK0.56247635
83PTK2B0.55810673
84MAP2K70.55725684
85NTRK10.55160628
86LRRK20.53514655
87TYRO30.53182137
88PIM20.52621072
89NUAK10.52160372
90MAPK130.51361492
91GRK50.50608365
92MAP3K10.48500309
93NEK10.47604524
94TGFBR10.46922105
95RPS6KA20.46894833
96SRC0.46894732
97FLT30.45961421
98PRKAA10.44495952
99FGFR10.44348265
100NEK20.43035982
101DYRK1A0.42909994
102ABL20.42085285
103PRKCE0.39662029
104DYRK1B0.39125578
105DAPK20.38643375
106PINK10.38057570
107RET0.37277468
108CAMK2A0.36982933
109MAPK150.36814828
110CAMK2B0.36804185
111CAMK2D0.36639952
112MST40.36135133
113CSNK1A10.35899534
114TTN0.35866697
115ARAF0.34357548
116MARK30.33031156
117GRK10.32839624
118HIPK20.32268456
119CDK50.31873136
120PLK20.31469282
121STK390.31135546
122PRKD10.30925097
123PDGFRA0.29890053
124MAPK70.28294937
125STK30.28099906
126IRAK20.27192732
127MINK10.27189665
128SGK4940.26869773
129SGK2230.26869773
130CSNK1G20.26789849
131SRPK10.26619570
132KIT0.26610434
133PIK3CA0.26209552
134STK100.26088400
135CDC42BPA0.25750879
136TYK20.25249770
137NLK0.24918848
138MAP3K70.23724808
139PRKG10.22604432
140SGK30.22211045
141SGK20.21840784
142GSK3A0.21200022
143IRAK10.20817829
144BCR0.19992749
145STK380.19692875
146PRKACG0.19544717
147PRKCH0.19477029
148KSR10.19302606
149ACVR1B0.19067195
150ZAK0.18852658
151PDK20.18750161
152BMX0.17347297
153MAPK120.16702140
154BMPR20.16542608
155MAPK110.15104811
156PRKCA0.14090187
157ROCK20.13778811
158PRKCZ0.13169121
159PRKACA0.12369159
160IGF1R0.11881100
161CAMK2G0.11636063
162EPHA20.10239025
163PRKCD0.09439071
164PHKG20.09362470

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001205.10053773
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.18537644
3Complement and coagulation cascades_Homo sapiens_hsa046103.06493689
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.01757684
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.67161346
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.58391885
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.51989312
8Fatty acid degradation_Homo sapiens_hsa000712.40826871
9Tryptophan metabolism_Homo sapiens_hsa003802.30884671
10Arginine biosynthesis_Homo sapiens_hsa002202.20372544
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.13248765
12Tyrosine metabolism_Homo sapiens_hsa003502.12237422
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07016895
14Chemical carcinogenesis_Homo sapiens_hsa052042.05107008
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95703907
16Phenylalanine metabolism_Homo sapiens_hsa003601.92473963
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86808267
18Retinol metabolism_Homo sapiens_hsa008301.86387492
19Bile secretion_Homo sapiens_hsa049761.86165567
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.84611484
21Nitrogen metabolism_Homo sapiens_hsa009101.83167130
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81057567
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.77213605
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76473433
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.70325318
26ABC transporters_Homo sapiens_hsa020101.70269764
27ECM-receptor interaction_Homo sapiens_hsa045121.66511011
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.65836406
29Sulfur metabolism_Homo sapiens_hsa009201.60611008
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.59560934
31Peroxisome_Homo sapiens_hsa041461.58261513
32Protein export_Homo sapiens_hsa030601.52934344
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.51809279
34Histidine metabolism_Homo sapiens_hsa003401.48326265
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44039947
36beta-Alanine metabolism_Homo sapiens_hsa004101.43488302
37PPAR signaling pathway_Homo sapiens_hsa033201.40512385
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39550951
39Butanoate metabolism_Homo sapiens_hsa006501.35484681
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.32155066
41Fatty acid elongation_Homo sapiens_hsa000621.29214175
42Mineral absorption_Homo sapiens_hsa049781.28695016
43Starch and sucrose metabolism_Homo sapiens_hsa005001.27989204
44Propanoate metabolism_Homo sapiens_hsa006401.26216961
45Dilated cardiomyopathy_Homo sapiens_hsa054141.26077530
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24470711
47Melanoma_Homo sapiens_hsa052181.24417422
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24090037
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23640680
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.23465198
51Gap junction_Homo sapiens_hsa045401.22061994
52Taste transduction_Homo sapiens_hsa047421.21657069
53Fatty acid metabolism_Homo sapiens_hsa012121.20074965
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.13894911
55Cocaine addiction_Homo sapiens_hsa050301.12521621
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12168734
57Staphylococcus aureus infection_Homo sapiens_hsa051501.11190350
58Regulation of actin cytoskeleton_Homo sapiens_hsa048101.09736040
59MicroRNAs in cancer_Homo sapiens_hsa052061.08181719
60Selenocompound metabolism_Homo sapiens_hsa004501.07263196
61Basal cell carcinoma_Homo sapiens_hsa052171.06544656
62Vibrio cholerae infection_Homo sapiens_hsa051101.05553722
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04477231
64Caffeine metabolism_Homo sapiens_hsa002321.02404469
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01769688
66Protein digestion and absorption_Homo sapiens_hsa049740.95064218
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93153326
68Glycerolipid metabolism_Homo sapiens_hsa005610.92444087
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.90304943
70Rap1 signaling pathway_Homo sapiens_hsa040150.90025301
71Adherens junction_Homo sapiens_hsa045200.86822421
72Vitamin B6 metabolism_Homo sapiens_hsa007500.85755924
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85022862
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78935236
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77198101
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75955265
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75789487
78Hippo signaling pathway_Homo sapiens_hsa043900.75014408
79Prion diseases_Homo sapiens_hsa050200.74803415
80Small cell lung cancer_Homo sapiens_hsa052220.74449417
81Pathways in cancer_Homo sapiens_hsa052000.70901024
82Olfactory transduction_Homo sapiens_hsa047400.69904262
83Lysine degradation_Homo sapiens_hsa003100.69199487
84Focal adhesion_Homo sapiens_hsa045100.68878726
85Amoebiasis_Homo sapiens_hsa051460.67941813
86Notch signaling pathway_Homo sapiens_hsa043300.66707098
87Prostate cancer_Homo sapiens_hsa052150.65999699
88Pyruvate metabolism_Homo sapiens_hsa006200.65011975
89Steroid biosynthesis_Homo sapiens_hsa001000.63605872
90Folate biosynthesis_Homo sapiens_hsa007900.63408649
91N-Glycan biosynthesis_Homo sapiens_hsa005100.63268257
92Proteoglycans in cancer_Homo sapiens_hsa052050.62331529
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61632473
94Dopaminergic synapse_Homo sapiens_hsa047280.58961030
95Biosynthesis of amino acids_Homo sapiens_hsa012300.57566315
96Circadian rhythm_Homo sapiens_hsa047100.56914779
97Pentose phosphate pathway_Homo sapiens_hsa000300.56861239
98GABAergic synapse_Homo sapiens_hsa047270.56640521
99Thyroid hormone synthesis_Homo sapiens_hsa049180.55633679
100Fat digestion and absorption_Homo sapiens_hsa049750.53442569
101Ras signaling pathway_Homo sapiens_hsa040140.52870610
102p53 signaling pathway_Homo sapiens_hsa041150.51603183
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51537994
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51494099
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.48367753
106TGF-beta signaling pathway_Homo sapiens_hsa043500.47934669
107Renin secretion_Homo sapiens_hsa049240.47537014
108Shigellosis_Homo sapiens_hsa051310.47196481
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.47063104
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45876142
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45000462
112Insulin resistance_Homo sapiens_hsa049310.44959531
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44369681
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.44265241
115Cholinergic synapse_Homo sapiens_hsa047250.44136578
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43644459
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43480444
118Carbon metabolism_Homo sapiens_hsa012000.42556981
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42240764
120Gastric acid secretion_Homo sapiens_hsa049710.42120550
121Phagosome_Homo sapiens_hsa041450.41745404
122Fructose and mannose metabolism_Homo sapiens_hsa000510.40991293
123Melanogenesis_Homo sapiens_hsa049160.39948405
124Choline metabolism in cancer_Homo sapiens_hsa052310.38394011
125Hedgehog signaling pathway_Homo sapiens_hsa043400.37836546
126Amphetamine addiction_Homo sapiens_hsa050310.36917213
127Glioma_Homo sapiens_hsa052140.36519815
128Bladder cancer_Homo sapiens_hsa052190.34672495
129Glutamatergic synapse_Homo sapiens_hsa047240.34540887
130Arginine and proline metabolism_Homo sapiens_hsa003300.34433884
131Fatty acid biosynthesis_Homo sapiens_hsa000610.34374075
132cAMP signaling pathway_Homo sapiens_hsa040240.33790339
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33388880
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33043658
135Endocytosis_Homo sapiens_hsa041440.30789238
136Circadian entrainment_Homo sapiens_hsa047130.30774550
137Glutathione metabolism_Homo sapiens_hsa004800.29404547
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29355377
139Axon guidance_Homo sapiens_hsa043600.25681642
140Wnt signaling pathway_Homo sapiens_hsa043100.25546678
141Metabolic pathways_Homo sapiens_hsa011000.24502433
142Vitamin digestion and absorption_Homo sapiens_hsa049770.24343621
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23631547
144Pancreatic secretion_Homo sapiens_hsa049720.23164857
145Sulfur relay system_Homo sapiens_hsa041220.21330758
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.21297216
147Tight junction_Homo sapiens_hsa045300.17691272
148Collecting duct acid secretion_Homo sapiens_hsa049660.17447915
149Maturity onset diabetes of the young_Homo sapiens_hsa049500.17073603
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15119093
151Glucagon signaling pathway_Homo sapiens_hsa049220.15055392
152Salivary secretion_Homo sapiens_hsa049700.14078347
153Renin-angiotensin system_Homo sapiens_hsa046140.13948628
154AMPK signaling pathway_Homo sapiens_hsa041520.13644062

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