MPDU1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an endoplasmic reticulum membrane protein that is required for utilization of the mannose donor mannose-P-dolichol in the synthesis of lipid-linked oligosaccharides and glycosylphosphatidylinositols. Mutations in this gene result in congenital disorder of glycosylation type If. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycine metabolic process (GO:0006544)5.07595696
2folic acid metabolic process (GO:0046655)4.90927895
3serine family amino acid biosynthetic process (GO:0009070)4.66962890
4negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.64638569
5serine family amino acid catabolic process (GO:0009071)4.56926639
6sulfur amino acid catabolic process (GO:0000098)4.44655654
7L-serine metabolic process (GO:0006563)4.39709526
8glycosphingolipid catabolic process (GO:0046479)4.31150458
9serine family amino acid metabolic process (GO:0009069)4.28304348
10L-phenylalanine metabolic process (GO:0006558)4.19756753
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.19756753
12glycolipid catabolic process (GO:0019377)4.05116767
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.95896572
14GDP-mannose metabolic process (GO:0019673)3.92481628
15cysteine metabolic process (GO:0006534)3.85641811
16amyloid precursor protein catabolic process (GO:0042987)3.84391221
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.83200984
18L-phenylalanine catabolic process (GO:0006559)3.83200984
19Golgi transport vesicle coating (GO:0048200)3.76838768
20COPI coating of Golgi vesicle (GO:0048205)3.76838768
21alpha-linolenic acid metabolic process (GO:0036109)3.76648504
22glyoxylate metabolic process (GO:0046487)3.68944747
23DNA deamination (GO:0045006)3.61156951
24purine nucleobase biosynthetic process (GO:0009113)3.60634911
25folic acid-containing compound biosynthetic process (GO:0009396)3.57427121
26protein maturation by protein folding (GO:0022417)3.53505718
27nucleobase biosynthetic process (GO:0046112)3.52509376
28aromatic amino acid family catabolic process (GO:0009074)3.50987154
29protein retention in ER lumen (GO:0006621)3.45970294
30folic acid transport (GO:0015884)3.45455980
31amino-acid betaine metabolic process (GO:0006577)3.44245021
32NIK/NF-kappaB signaling (GO:0038061)3.41027690
33kynurenine metabolic process (GO:0070189)3.40944900
34negative regulation of cholesterol transport (GO:0032375)3.35314318
35negative regulation of sterol transport (GO:0032372)3.35314318
36folic acid-containing compound metabolic process (GO:0006760)3.34520411
37ribosome assembly (GO:0042255)3.34336406
38ceramide catabolic process (GO:0046514)3.33423832
39sulfur amino acid biosynthetic process (GO:0000097)3.30807702
40indole-containing compound catabolic process (GO:0042436)3.29217659
41indolalkylamine catabolic process (GO:0046218)3.29217659
42tryptophan catabolic process (GO:0006569)3.29217659
43barbed-end actin filament capping (GO:0051016)3.27419622
44maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.21524371
45homocysteine metabolic process (GO:0050667)3.20424122
46deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.19950156
47urea cycle (GO:0000050)3.19185488
48urea metabolic process (GO:0019627)3.19185488
49pentose-phosphate shunt (GO:0006098)3.17873468
50pentose metabolic process (GO:0019321)3.13955598
51negative regulation of fibrinolysis (GO:0051918)3.13539173
52UV protection (GO:0009650)3.13162798
53high-density lipoprotein particle remodeling (GO:0034375)3.12064843
54pinocytosis (GO:0006907)3.11172846
55sphingolipid catabolic process (GO:0030149)3.10985005
56nucleobase-containing small molecule interconversion (GO:0015949)3.10491477
57nitrogen cycle metabolic process (GO:0071941)3.10236120
58nucleoside salvage (GO:0043174)3.10003429
59tetrahydrofolate metabolic process (GO:0046653)3.09815038
60imidazole-containing compound metabolic process (GO:0052803)3.08825444
61membrane lipid catabolic process (GO:0046466)3.08564100
62formation of translation preinitiation complex (GO:0001731)3.07707530
63alpha-amino acid catabolic process (GO:1901606)3.07657446
64bile acid biosynthetic process (GO:0006699)3.06553497
65pantothenate metabolic process (GO:0015939)3.04183167
66heme transport (GO:0015886)3.02134629
67NADPH regeneration (GO:0006740)3.02050864
68tryptophan metabolic process (GO:0006568)3.00450070
69cellular amino acid catabolic process (GO:0009063)2.99518991
70regulation of cholesterol esterification (GO:0010872)2.97973142
71cellular modified amino acid catabolic process (GO:0042219)2.97615081
72L-methionine salvage (GO:0071267)2.96818542
73L-methionine biosynthetic process (GO:0071265)2.96818542
74amino acid salvage (GO:0043102)2.96818542
75glucose catabolic process (GO:0006007)2.95021082
76aromatic amino acid family metabolic process (GO:0009072)2.94922971
77sulfur amino acid metabolic process (GO:0000096)2.93795352
78lysine catabolic process (GO:0006554)2.93058509
79lysine metabolic process (GO:0006553)2.93058509
80one-carbon metabolic process (GO:0006730)2.91700915
81pteridine-containing compound metabolic process (GO:0042558)2.91024121
82regulation of protein activation cascade (GO:2000257)2.90817762
83ethanol oxidation (GO:0006069)2.90209816
84pyrimidine nucleoside salvage (GO:0043097)2.89788629
85pyrimidine-containing compound salvage (GO:0008655)2.89788629
86regulation of triglyceride catabolic process (GO:0010896)2.88895307
87protein localization to endosome (GO:0036010)2.88780557
88proteasome assembly (GO:0043248)2.88130618
89oligosaccharide catabolic process (GO:0009313)2.85465083
90fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.85458915
91fructose metabolic process (GO:0006000)2.84009403
92valine metabolic process (GO:0006573)2.83937970
93proline metabolic process (GO:0006560)2.83407926
94reverse cholesterol transport (GO:0043691)2.82256076
95positive regulation of triglyceride metabolic process (GO:0090208)2.82016633
96ribosome biogenesis (GO:0042254)2.81994075
97pteridine-containing compound biosynthetic process (GO:0042559)2.81674842
98bile acid metabolic process (GO:0008206)2.80113321
99ribosomal small subunit biogenesis (GO:0042274)2.79632821
100hyaluronan catabolic process (GO:0030214)2.79110812
101plasma lipoprotein particle clearance (GO:0034381)2.78913513
102regulation of vitamin metabolic process (GO:0030656)2.78906026
103negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.78337279
104biotin metabolic process (GO:0006768)2.77392734
105positive regulation of triglyceride lipase activity (GO:0061365)2.76384730
106positive regulation of lipoprotein lipase activity (GO:0051006)2.76384730
107branched-chain amino acid catabolic process (GO:0009083)2.76063904
108regulation of complement activation (GO:0030449)2.75788656
109DNA strand elongation involved in DNA replication (GO:0006271)2.75538251
110triglyceride homeostasis (GO:0070328)2.74511333
111acylglycerol homeostasis (GO:0055090)2.74511333
112methionine metabolic process (GO:0006555)2.73461267
113plasma lipoprotein particle remodeling (GO:0034369)2.72532038
114protein-lipid complex remodeling (GO:0034368)2.72532038
115macromolecular complex remodeling (GO:0034367)2.72532038
116negative regulation of fatty acid biosynthetic process (GO:0045717)2.70773012
117regulation of vitamin D biosynthetic process (GO:0060556)2.69410596
118ribonucleoprotein complex biogenesis (GO:0022613)2.69103030
119acetyl-CoA metabolic process (GO:0006084)2.67980203
120positive regulation of triglyceride biosynthetic process (GO:0010867)2.67171905
121alpha-amino acid biosynthetic process (GO:1901607)2.67082062
122methionine biosynthetic process (GO:0009086)2.66917024
123regulation of cholesterol homeostasis (GO:2000188)2.66810151
124proline biosynthetic process (GO:0006561)2.65586369
125maturation of SSU-rRNA (GO:0030490)2.65428309
126amino sugar catabolic process (GO:0046348)2.65256790
127organic acid catabolic process (GO:0016054)2.64442698
128carboxylic acid catabolic process (GO:0046395)2.64442698
129low-density lipoprotein particle clearance (GO:0034383)2.61818262
130adhesion of symbiont to host (GO:0044406)2.60728771
131positive regulation of lymphocyte apoptotic process (GO:0070230)2.59701395
132virion attachment to host cell (GO:0019062)2.58682279
133adhesion of symbiont to host cell (GO:0044650)2.58682279
134regulation of superoxide anion generation (GO:0032928)2.57705857
135regulation of podosome assembly (GO:0071801)2.56735954
136response to peptidoglycan (GO:0032494)2.46532709
137response to thyroid hormone (GO:0097066)2.45208680
138negative regulation of myeloid cell apoptotic process (GO:0033033)2.45147045
139myeloid cell homeostasis (GO:0002262)2.44169414
140cyclooxygenase pathway (GO:0019371)2.43188289
141cellular response to arsenic-containing substance (GO:0071243)2.42904049
142glucose 6-phosphate metabolic process (GO:0051156)2.39209175
143mannose metabolic process (GO:0006013)2.39055993
144modulation by symbiont of host cellular process (GO:0044068)2.38810257
145endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.38227202
146fat-soluble vitamin biosynthetic process (GO:0042362)2.38197446
147heme metabolic process (GO:0042168)2.35726609
148positive regulation of Cdc42 GTPase activity (GO:0043089)2.35684177
149nucleoside diphosphate biosynthetic process (GO:0009133)2.35108347
150glycoside metabolic process (GO:0016137)2.34993453
151regulation of cholesterol storage (GO:0010885)2.32658821
152virion assembly (GO:0019068)2.32463727
153retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.31612048
154positive regulation of chemokine biosynthetic process (GO:0045080)2.30953778
155regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.30274879
156positive regulation of receptor biosynthetic process (GO:0010870)2.29018510
157monosaccharide biosynthetic process (GO:0046364)2.28310632
158positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.28026677
159heme biosynthetic process (GO:0006783)2.27133380
160mitotic nuclear envelope reassembly (GO:0007084)2.27042718
161nuclear envelope reassembly (GO:0031468)2.27042718
162regulation of mononuclear cell migration (GO:0071675)2.27039554
163mitochondrial fusion (GO:0008053)2.26738147
164glial cell migration (GO:0008347)2.25016583
165regulation of chemokine biosynthetic process (GO:0045073)2.24963474
166regulation of release of cytochrome c from mitochondria (GO:0090199)2.24557951
167positive regulation of T cell apoptotic process (GO:0070234)2.23608591
168regulation of mammary gland epithelial cell proliferation (GO:0033599)2.21378017
169chaperone mediated protein folding requiring cofactor (GO:0051085)2.21263498
170telomere maintenance via semi-conservative replication (GO:0032201)2.20637777
171positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.20245118
172leukocyte apoptotic process (GO:0071887)2.19031869
173T cell apoptotic process (GO:0070231)2.18692822
174NADH metabolic process (GO:0006734)2.18171828
175N-acetylneuraminate metabolic process (GO:0006054)2.17719777
176positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.16717829
177activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.15805491
178Arp2/3 complex-mediated actin nucleation (GO:0034314)2.15776666
179negative regulation of nitric oxide biosynthetic process (GO:0045019)2.15736782
180pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.14772896
181UTP biosynthetic process (GO:0006228)2.13514332
182lipopolysaccharide-mediated signaling pathway (GO:0031663)2.13485137
183regulation of mitochondrial membrane potential (GO:0051881)2.12754589
184decidualization (GO:0046697)2.12558636
185glutamine family amino acid biosynthetic process (GO:0009084)2.12170970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.20776180
2E2F7_22180533_ChIP-Seq_HELA_Human4.20214030
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.36621131
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35871710
5* PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.00140391
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.87022998
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.77253509
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54625384
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54039360
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.53366961
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49121594
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.42448624
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.39370699
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.35246313
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27546070
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25587574
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.24410116
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19268144
19LXR_22292898_ChIP-Seq_THP-1_Human2.17872044
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17673409
21* EST1_17652178_ChIP-ChIP_JURKAT_Human2.05157194
22EGR1_23403033_ChIP-Seq_LIVER_Mouse1.98939095
23NANOG_18555785_ChIP-Seq_MESCs_Mouse1.97928444
24* ELK3_25401928_ChIP-Seq_HUVEC_Human1.97808019
25* GABP_17652178_ChIP-ChIP_JURKAT_Human1.95850935
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.95015143
27XRN2_22483619_ChIP-Seq_HELA_Human1.92079955
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90474865
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83327966
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79908716
31LXR_22158963_ChIP-Seq_LIVER_Mouse1.78952099
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78741679
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73691052
34* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.69102072
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.68736792
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68672530
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64638012
38* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.64391286
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59363847
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58014758
41RACK7_27058665_Chip-Seq_MCF-7_Human1.57818575
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55487529
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54405018
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53091393
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.52911885
46DCP1A_22483619_ChIP-Seq_HELA_Human1.51662065
47GABP_19822575_ChIP-Seq_HepG2_Human1.50753281
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49898259
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49500049
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45575537
51AR_21909140_ChIP-Seq_LNCAP_Human1.44944422
52VDR_23849224_ChIP-Seq_CD4+_Human1.44913897
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44741255
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42530891
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42427058
56NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.42384828
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.39021615
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.37901059
59* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37822871
60P68_20966046_ChIP-Seq_HELA_Human1.37594931
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37475174
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37140903
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34804125
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34642502
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.34620728
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.34620728
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.34620728
68ZNF263_19887448_ChIP-Seq_K562_Human1.33418434
69* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31284930
70* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.30721927
71* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30569428
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30265841
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29718647
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28169593
75FOXP3_21729870_ChIP-Seq_TREG_Human1.28100460
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26198030
77BCOR_27268052_Chip-Seq_Bcells_Human1.25908140
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25754147
79BCL6_27268052_Chip-Seq_Bcells_Human1.24786646
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24605048
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24601404
82KDM5A_27292631_Chip-Seq_BREAST_Human1.24357802
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24153466
84* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.23983028
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.23720383
86MYC_22102868_ChIP-Seq_BL_Human1.21801514
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21247106
88* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20635144
89CTCF_18555785_ChIP-Seq_MESCs_Mouse1.20004032
90* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19633108
91TFEB_21752829_ChIP-Seq_HELA_Human1.19586461
92VDR_24763502_ChIP-Seq_THP-1_Human1.18931966
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18784046
94IRF8_22096565_ChIP-ChIP_GC-B_Human1.16900232
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16129616
96* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15890380
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15837734
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15508782
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14732162
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14646488
101* TTF2_22483619_ChIP-Seq_HELA_Human1.13166902
102SRF_21415370_ChIP-Seq_HL-1_Mouse1.12028459
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11457187
104CTCF_26484167_Chip-Seq_Bcells_Mouse1.10278474
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10097915
106MAF_26560356_Chip-Seq_TH1_Human1.09340518
107* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08784527
108ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08527682
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07793122
110TP63_17297297_ChIP-ChIP_HaCaT_Human1.07356210
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07228345
112CIITA_25753668_ChIP-Seq_RAJI_Human1.06584349
113MAF_26560356_Chip-Seq_TH2_Human1.06567230
114* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06263412
115ATF3_27146783_Chip-Seq_COLON_Human1.06077368
116* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05651821
117CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05596532
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05360357
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05111414
120KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04793515
121SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03651252
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02807093
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02654200
124SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02168118
125UTX_26944678_Chip-Seq_JUKART_Human1.01948457
126TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01928911
127PHF8_20622854_ChIP-Seq_HELA_Human1.01634089
128SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01215197
129ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00834180
130NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00302474
131* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98728822
132SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98308938
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98305570
134* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.97231559
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95989969
136* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95653052
137VDR_21846776_ChIP-Seq_THP-1_Human0.94966865
138YY1_22570637_ChIP-Seq_MALME-3M_Human0.94349392
139FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94145359
140TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92898847
141SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92206692
142SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91949703
143* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.91340637
144* TET1_21451524_ChIP-Seq_MESCs_Mouse0.91009871
145PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89287247
146* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.89122970
147* FOXP1_21924763_ChIP-Seq_HESCs_Human0.87141252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.32513731
2MP0005360_urolithiasis5.06812372
3MP0009840_abnormal_foam_cell4.65861744
4MP0003806_abnormal_nucleotide_metabolis4.63324037
5MP0005365_abnormal_bile_salt4.11840581
6MP0005085_abnormal_gallbladder_physiolo3.98484473
7MP0004858_abnormal_nervous_system3.65546720
8MP0003693_abnormal_embryo_hatching3.51101304
9MP0008875_abnormal_xenobiotic_pharmacok3.15254887
10MP0010329_abnormal_lipoprotein_level2.76047896
11MP0004957_abnormal_blastocyst_morpholog2.61084174
12MP0005332_abnormal_amino_acid2.57445607
13MP0004019_abnormal_vitamin_homeostasis2.41879219
14MP0003436_decreased_susceptibility_to2.40802192
15MP0003111_abnormal_nucleus_morphology2.36133042
16MP0003075_altered_response_to2.33007737
17MP0003191_abnormal_cellular_cholesterol2.32719818
18MP0003172_abnormal_lysosome_physiology2.19703181
19MP0003303_peritoneal_inflammation2.15723693
20MP0003186_abnormal_redox_activity2.06797990
21MP0001666_abnormal_nutrient_absorption2.04434260
22MP0002148_abnormal_hypersensitivity_rea2.03574781
23MP0000343_altered_response_to1.93551802
24MP0000609_abnormal_liver_physiology1.93489836
25MP0003718_maternal_effect1.89752109
26MP0006082_CNS_inflammation1.89529705
27MP0005083_abnormal_biliary_tract1.89494373
28MP0005670_abnormal_white_adipose1.77865890
29MP0002877_abnormal_melanocyte_morpholog1.77411558
30MP0003252_abnormal_bile_duct1.77149140
31MP0009785_altered_susceptibility_to1.76027941
32MP0001849_ear_inflammation1.74864165
33MP0003077_abnormal_cell_cycle1.67330124
34MP0003011_delayed_dark_adaptation1.66783234
35MP0003705_abnormal_hypodermis_morpholog1.66777445
36MP0005319_abnormal_enzyme/_coenzyme1.66695310
37MP0005025_abnormal_response_to1.60487196
38MP0003300_gastrointestinal_ulcer1.57947429
39MP0002118_abnormal_lipid_homeostasis1.57904222
40MP0002419_abnormal_innate_immunity1.55268257
41MP0010094_abnormal_chromosome_stability1.51033918
42MP0001764_abnormal_homeostasis1.46385752
43MP0009764_decreased_sensitivity_to1.45385756
44MP0009643_abnormal_urine_homeostasis1.42206447
45MP0003453_abnormal_keratinocyte_physiol1.41738486
46MP0001835_abnormal_antigen_presentation1.41506479
47MP0008932_abnormal_embryonic_tissue1.41088560
48MP0005257_abnormal_intraocular_pressure1.40152242
49MP0004947_skin_inflammation1.39563444
50MP0010352_gastrointestinal_tract_polyps1.33999653
51MP0001730_embryonic_growth_arrest1.32578839
52MP0010155_abnormal_intestine_physiology1.32231600
53MP0003329_amyloid_beta_deposits1.32105235
54MP0005387_immune_system_phenotype1.29678224
55MP0001790_abnormal_immune_system1.29678224
56MP0005000_abnormal_immune_tolerance1.28602625
57MP0006035_abnormal_mitochondrial_morpho1.26271042
58MP0009278_abnormal_bone_marrow1.24059154
59MP0008260_abnormal_autophagy1.23885995
60MP0001845_abnormal_inflammatory_respons1.23501961
61MP0001533_abnormal_skeleton_physiology1.22586525
62MP0004133_heterotaxia1.21874592
63MP0000598_abnormal_liver_morphology1.18831921
64MP0008058_abnormal_DNA_repair1.18667062
65MP0006036_abnormal_mitochondrial_physio1.18430462
66MP0002254_reproductive_system_inflammat1.16988937
67MP0000685_abnormal_immune_system1.15730799
68MP0005464_abnormal_platelet_physiology1.13637690
69MP0003195_calcinosis1.13333004
70MP0005165_increased_susceptibility_to1.12619760
71MP0005584_abnormal_enzyme/coenzyme_acti1.12519366
72MP0002452_abnormal_antigen_presenting1.10619007
73MP0002653_abnormal_ependyma_morphology1.07956197
74MP0005671_abnormal_response_to1.07417324
75MP0005451_abnormal_body_composition1.06605641
76MP0005058_abnormal_lysosome_morphology1.06164346
77MP0000490_abnormal_crypts_of1.04611828
78MP0005166_decreased_susceptibility_to1.03714527
79MP0002723_abnormal_immune_serum1.03612339
80MP0001727_abnormal_embryo_implantation1.03484250
81MP0000350_abnormal_cell_proliferation0.99808749
82MP0001756_abnormal_urination0.98711316
83MP0003448_altered_tumor_morphology0.96654188
84MP0004233_abnormal_muscle_weight0.95840944
85MP0005380_embryogenesis_phenotype0.94508587
86MP0001672_abnormal_embryogenesis/_devel0.94508587
87MP0001661_extended_life_span0.94267330
88MP0000358_abnormal_cell_content/0.94217561
89MP0001853_heart_inflammation0.93438114
90MP0004264_abnormal_extraembryonic_tissu0.92261867
91MP0002080_prenatal_lethality0.91893494
92MP0001819_abnormal_immune_cell0.91579852
93MP0002132_abnormal_respiratory_system0.90618604
94MP0002420_abnormal_adaptive_immunity0.89376415
95MP0002138_abnormal_hepatobiliary_system0.88243625
96MP0002998_abnormal_bone_remodeling0.87335099
97MP0005666_abnormal_adipose_tissue0.85871836
98MP0002405_respiratory_system_inflammati0.84889814
99MP0009333_abnormal_splenocyte_physiolog0.83707584
100MP0010030_abnormal_orbit_morphology0.82788819
101MP0002019_abnormal_tumor_incidence0.82602706
102MP0005266_abnormal_metabolism0.82068689
103MP0003656_abnormal_erythrocyte_physiolo0.81890734
104MP0010234_abnormal_vibrissa_follicle0.80987277
105MP0001697_abnormal_embryo_size0.80327908
106MP0001545_abnormal_hematopoietic_system0.80020004
107MP0005397_hematopoietic_system_phenotyp0.80020004
108MP0002088_abnormal_embryonic_growth/wei0.79703681
109MP0003984_embryonic_growth_retardation0.79666711
110MP0001663_abnormal_digestive_system0.79413605
111MP0001873_stomach_inflammation0.78526107
112MP0005395_other_phenotype0.78345819
113MP0004510_myositis0.78237378
114MP0001881_abnormal_mammary_gland0.77928549
115MP0008469_abnormal_protein_level0.77102161
116MP0010307_abnormal_tumor_latency0.76726551
117MP0008004_abnormal_stomach_pH0.76681866
118MP0002136_abnormal_kidney_physiology0.76361201
119MP0008007_abnormal_cellular_replicative0.76145079
120MP0002429_abnormal_blood_cell0.74323457
121MP0003868_abnormal_feces_composition0.74214489
122MP0003786_premature_aging0.73887681
123MP0002086_abnormal_extraembryonic_tissu0.72585363
124MP0001800_abnormal_humoral_immune0.72525533
125MP0003890_abnormal_embryonic-extraembry0.72044918
126MP0000678_abnormal_parathyroid_gland0.71812099
127MP0009053_abnormal_anal_canal0.70343640
128MP0000477_abnormal_intestine_morphology0.70258891
129MP0002796_impaired_skin_barrier0.70134940
130MP0005376_homeostasis/metabolism_phenot0.69485390
131MP0003566_abnormal_cell_adhesion0.69277259
132MP0002970_abnormal_white_adipose0.69105665
133MP0003119_abnormal_digestive_system0.68953345
134MP0005023_abnormal_wound_healing0.68852040
135MP0001216_abnormal_epidermal_layer0.68663791
136MP0009763_increased_sensitivity_to0.68574852
137MP0001243_abnormal_dermal_layer0.68459426
138MP0000604_amyloidosis0.68444904
139MP0005377_hearing/vestibular/ear_phenot0.67994411
140MP0003878_abnormal_ear_physiology0.67994411
141MP0001542_abnormal_bone_strength0.67509365
142MP0004782_abnormal_surfactant_physiolog0.67435887
143MP0002085_abnormal_embryonic_tissue0.67391769
144MP0009642_abnormal_blood_homeostasis0.67323718
145MP0005636_abnormal_mineral_homeostasis0.67115566
146MP0000858_altered_metastatic_potential0.66060686
147MP0009672_abnormal_birth_weight0.64464276
148MP0009765_abnormal_xenobiotic_induced0.62421987
149MP0000313_abnormal_cell_death0.61729549
150MP0004197_abnormal_fetal_growth/weight/0.59538439
151MP0005501_abnormal_skin_physiology0.57851665
152MP0003221_abnormal_cardiomyocyte_apopto0.57628469
153MP0002084_abnormal_developmental_patter0.55594839
154MP0005647_abnormal_sex_gland0.55578040
155MP0002111_abnormal_tail_morphology0.53956618
156MP0001293_anophthalmia0.53579981

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.71038164
2Abnormality of liposaccharide metabolism (HP:0010968)5.71038164
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.71038164
4Hyperglycinuria (HP:0003108)5.49066468
5Hyperglycinemia (HP:0002154)5.13721105
6Abnormality of serine family amino acid metabolism (HP:0010894)4.90737720
7Abnormality of glycine metabolism (HP:0010895)4.90737720
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.77638065
9Abnormality of aromatic amino acid family metabolism (HP:0004338)4.54509852
10Increased cerebral lipofuscin (HP:0011813)4.38778260
11Xanthomatosis (HP:0000991)4.34538660
12Hypobetalipoproteinemia (HP:0003563)4.27544628
13Hyperammonemia (HP:0001987)4.21129786
14Intrahepatic cholestasis (HP:0001406)4.14086280
15Abnormality of pyrimidine metabolism (HP:0004353)3.99759630
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.96178719
17Vacuolated lymphocytes (HP:0001922)3.94177951
18Hyperlipoproteinemia (HP:0010980)3.86130901
19Vertebral compression fractures (HP:0002953)3.77999436
20Deep venous thrombosis (HP:0002625)3.70124675
21Dysostosis multiplex (HP:0000943)3.67674204
22Multiple enchondromatosis (HP:0005701)3.45339440
23Abnormality of serum amino acid levels (HP:0003112)3.44706257
24Hypolipoproteinemia (HP:0010981)3.40837800
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.39774134
26Loss of speech (HP:0002371)3.25916519
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.23680368
28Abnormality of fatty-acid metabolism (HP:0004359)3.14935061
29Abnormality of mucopolysaccharide metabolism (HP:0011020)3.10042409
30Abnormality of polysaccharide metabolism (HP:0011012)3.10042409
31Abnormality of glycosaminoglycan metabolism (HP:0004371)3.10042409
32Abnormality of dicarboxylic acid metabolism (HP:0010995)3.06451754
33Dicarboxylic aciduria (HP:0003215)3.06451754
34Hypoalphalipoproteinemia (HP:0003233)3.05158434
35Breast hypoplasia (HP:0003187)3.02782034
36Oral leukoplakia (HP:0002745)3.00222226
37Lethargy (HP:0001254)2.93159725
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.91490743
39Mucopolysacchariduria (HP:0008155)2.90738929
40Urinary glycosaminoglycan excretion (HP:0003541)2.90738929
41Gout (HP:0001997)2.89816773
42Ketosis (HP:0001946)2.87905009
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.86925257
44Prolonged partial thromboplastin time (HP:0003645)2.86001572
45Complement deficiency (HP:0004431)2.82666372
46Abnormality of nucleobase metabolism (HP:0010932)2.80785942
47Abnormality of methionine metabolism (HP:0010901)2.80395892
48Spastic diplegia (HP:0001264)2.76395059
49Megaloblastic anemia (HP:0001889)2.73212585
50Delayed CNS myelination (HP:0002188)2.69115469
51Hypoglycemic coma (HP:0001325)2.65684445
52Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.65057822
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.65032775
54Abnormality of macrophages (HP:0004311)2.64807687
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.62148685
56Nausea (HP:0002018)2.62040861
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.53180102
58Abnormal cartilage morphology (HP:0002763)2.50746495
59Purpura (HP:0000979)2.46072229
60Reticulocytopenia (HP:0001896)2.44735026
61Axonal loss (HP:0003447)2.41307190
62Thoracic kyphosis (HP:0002942)2.40931357
63Progressive neurologic deterioration (HP:0002344)2.34101828
64Upper motor neuron abnormality (HP:0002127)2.34045349
65Abnormal gallbladder physiology (HP:0012438)2.31949159
66Cholecystitis (HP:0001082)2.31949159
67Irritability (HP:0000737)2.31745373
68Nuclear cataract (HP:0100018)2.31263609
69Malnutrition (HP:0004395)2.29365467
70Impulsivity (HP:0100710)2.28711456
71Ragged-red muscle fibers (HP:0003200)2.28493158
72Abnormality of complement system (HP:0005339)2.26691702
73Abnormal trabecular bone morphology (HP:0100671)2.26479188
74Achilles tendon contracture (HP:0001771)2.24545999
75Epidermoid cyst (HP:0200040)2.22851109
76Rough bone trabeculation (HP:0100670)2.22209271
77Birth length less than 3rd percentile (HP:0003561)2.21923890
78Abnormality of purine metabolism (HP:0004352)2.21299098
79Fat malabsorption (HP:0002630)2.19306536
80Macrocytic anemia (HP:0001972)2.18483967
81Progressive muscle weakness (HP:0003323)2.18058652
82Opisthotonus (HP:0002179)2.17849405
83Hypertensive crisis (HP:0100735)2.14218578
84Hemorrhage of the eye (HP:0011885)2.14189701
85Recurrent abscess formation (HP:0002722)2.12874553
86Chronic obstructive pulmonary disease (HP:0006510)2.12118821
87Obstructive lung disease (HP:0006536)2.12118821
88Amyloidosis (HP:0011034)2.10936851
89Abnormality of the Achilles tendon (HP:0005109)2.10572915
90Autoimmune thrombocytopenia (HP:0001973)2.10337980
91Spastic paraparesis (HP:0002313)2.10124016
92Death in infancy (HP:0001522)2.10052200
93Microretrognathia (HP:0000308)2.06376005
94Hepatosplenomegaly (HP:0001433)2.06351478
95Glomerulonephritis (HP:0000099)2.05542763
96Carpal bone hypoplasia (HP:0001498)2.04962590
97CNS demyelination (HP:0007305)2.04267690
98Abnormality of the thoracic spine (HP:0100711)2.01373485
99Cerebral hypomyelination (HP:0006808)2.01049598
100Ependymoma (HP:0002888)2.00142511
101Recurrent bacterial skin infections (HP:0005406)1.99931919
102Hyperacusis (HP:0010780)1.99911789
103Joint hemorrhage (HP:0005261)1.99848840
104Distal upper limb amyotrophy (HP:0007149)1.99072730
105Upper limb amyotrophy (HP:0009129)1.99072730
106Vomiting (HP:0002013)1.97891027
107Hypercholesterolemia (HP:0003124)1.96489006
108Premature ovarian failure (HP:0008209)1.95533652
109Polygenic inheritance (HP:0010982)1.94545130
110Hyperbilirubinemia (HP:0002904)1.93904841
111Elevated alkaline phosphatase (HP:0003155)1.93814541
112Neurofibrillary tangles (HP:0002185)1.93567655
113Abnormality of cells of the erythroid lineage (HP:0012130)1.93528284
114Petechiae (HP:0000967)1.93328783
115Pseudobulbar signs (HP:0002200)1.92494731
116Brushfield spots (HP:0001088)1.92188168
117Metabolic acidosis (HP:0001942)1.91436541
118Prolonged neonatal jaundice (HP:0006579)1.91008900
119Hypokinesia (HP:0002375)1.90712978
120Abnormality of the common coagulation pathway (HP:0010990)1.90061273
121Hydroxyprolinuria (HP:0003080)1.89464513
122Abnormality of proline metabolism (HP:0010907)1.89464513
123Esophageal varix (HP:0002040)1.88898261
124Abnormality of the intrinsic pathway (HP:0010989)1.87275523
125Abnormality of iron homeostasis (HP:0011031)1.87009743
1263-Methylglutaconic aciduria (HP:0003535)1.84449293
127Sparse eyelashes (HP:0000653)1.84088033
128Interstitial pulmonary disease (HP:0006530)1.83268383
129Ketoacidosis (HP:0001993)1.83113537
130Trismus (HP:0000211)1.82081533
131Generalized aminoaciduria (HP:0002909)1.82075264
132Cervical subluxation (HP:0003308)1.82048811
133Mediastinal lymphadenopathy (HP:0100721)1.81962497
134J-shaped sella turcica (HP:0002680)1.81479965
135Long palpebral fissure (HP:0000637)1.81236155
136Increased purine levels (HP:0004368)1.80522961
137Hyperuricemia (HP:0002149)1.80522961
138Cholelithiasis (HP:0001081)1.80498299
139Hypertriglyceridemia (HP:0002155)1.80256182
140Myocardial infarction (HP:0001658)1.80255306
141Pancreatitis (HP:0001733)1.80199171
142Reduced antithrombin III activity (HP:0001976)1.80049656
143Thin bony cortex (HP:0002753)1.79936648
144Abnormality of alkaline phosphatase activity (HP:0004379)1.79658161
145Reticulocytosis (HP:0001923)1.78899557
146Hand muscle atrophy (HP:0009130)1.78275579
147Systemic lupus erythematosus (HP:0002725)1.78095290
148Late onset (HP:0003584)1.77394255
149Cardiomegaly (HP:0001640)1.77022465
150Abnormality of the distal phalanges of the toes (HP:0010182)1.76683480
151Premature rupture of membranes (HP:0001788)1.76226339
152Secondary amenorrhea (HP:0000869)1.75351860
153Multiple lipomas (HP:0001012)1.75267812
154Steatorrhea (HP:0002570)1.75236050
155Pathologic fracture (HP:0002756)1.74752046
156Cerebral edema (HP:0002181)1.74642172
157Abnormality of transition element cation homeostasis (HP:0011030)1.74417181
158Neonatal onset (HP:0003623)1.74245667
159Cerebral palsy (HP:0100021)1.73543722
160Microvesicular hepatic steatosis (HP:0001414)1.73542616
161Nonimmune hydrops fetalis (HP:0001790)1.73004173
162Bone pain (HP:0002653)1.72660547
163Eczematoid dermatitis (HP:0000976)1.72257065
164Abnormal protein N-linked glycosylation (HP:0012347)1.71958582
165Abnormal protein glycosylation (HP:0012346)1.71958582
166Abnormal glycosylation (HP:0012345)1.71958582
167Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71958582
168Fasciculations (HP:0002380)1.71547062
169Ureteral duplication (HP:0000073)1.71051291
170Hyperparathyroidism (HP:0000843)1.70284431
171Back pain (HP:0003418)1.69355378
172Increased serum ferritin (HP:0003281)1.68838062
173Abnormal enzyme/coenzyme activity (HP:0012379)1.68764739
174Proximal tubulopathy (HP:0000114)1.68601379
175Personality changes (HP:0000751)1.67844530
176Abnormality of the nasal mucosa (HP:0000433)1.65796470
177Abnormality of reticulocytes (HP:0004312)1.64242102

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.98322388
2BCKDK4.12740112
3EPHA23.91631020
4WEE13.73040745
5SMG13.05412389
6TESK22.89877627
7NME22.79344671
8STK162.79047611
9VRK22.61924391
10NEK12.33963592
11RPS6KB22.14388068
12ERN12.11133255
13TTK2.09918855
14DYRK32.02110797
15NEK22.01712961
16TRIB31.93896347
17EIF2AK11.84452818
18TBK11.76175913
19PRPF4B1.73688701
20MAP3K111.66054741
21RPS6KA41.49657885
22LIMK11.48665696
23CDK71.47731399
24IRAK31.42597279
25MAP3K81.42143326
26TSSK61.41848916
27PLK41.41196113
28SIK11.38839220
29PRKD31.37800349
30PLK11.35697715
31EIF2AK31.35352676
32GRK61.34851913
33AKT31.34422009
34PAK41.33756388
35MAP2K21.30302841
36BLK1.27600734
37CDK41.26488318
38RIPK11.22139599
39KDR1.20881753
40MAP4K11.19447859
41AURKA1.19018792
42PKN21.16453071
43TLK11.10780585
44MAPKAPK31.10617498
45FGFR41.10556332
46LRRK21.08325627
47AURKB1.08007943
48TESK11.07147942
49VRK11.03799917
50PRKCI0.99967295
51CDK80.98904129
52SCYL20.98362493
53EEF2K0.96788431
54LMTK20.96134371
55IRAK40.95868926
56DAPK30.95685232
57TAOK20.92057665
58PIM20.91248924
59FLT30.89913694
60MST1R0.88923042
61CDC70.87092575
62MOS0.86340426
63DDR20.86176342
64ABL20.85122899
65MAPK110.84876924
66STK100.84372947
67SRPK10.82261256
68MAP3K140.81577574
69CHEK20.80496925
70BRAF0.78694687
71DYRK20.76957814
72TAOK10.76311471
73PAK10.74477926
74ALK0.73306374
75DAPK10.73153955
76MAP3K10.72688923
77BRSK10.72371717
78PRKD20.70240971
79LATS20.69688759
80ZAP700.68412111
81IKBKB0.68250971
82PIM10.68091955
83TYK20.67369834
84PASK0.67362366
85BRSK20.66116313
86CSNK1G30.65626352
87ILK0.65541214
88ATR0.65266565
89PTK60.64660704
90PBK0.64252774
91TGFBR20.63903766
92RPS6KA20.60186474
93CHEK10.59403754
94PINK10.59110812
95CDK60.57900518
96ACVR1B0.55848044
97ICK0.54980331
98MTOR0.53777419
99CSNK1A1L0.53443765
100EPHB20.53198262
101PDPK10.52952556
102CSNK2A10.52881174
103CSNK2A20.52562289
104MAP3K30.52381944
105GRK70.52155007
106AKT20.50107224
107MAP3K100.49122542
108CDC42BPA0.48688000
109CDK140.47875987
110MAP2K30.46888452
111CLK10.46727324
112CDK120.46309281
113MAP3K60.45902417
114RPS6KL10.45633869
115RPS6KC10.45633869
116MAP3K50.45584691
117PLK30.44289957
118CDK20.44008060
119SIK30.43114997
120CDK11A0.42104722
121CSF1R0.41706847
122CDK90.40175658
123CDK150.40021972
124ERBB40.39982984
125IRAK20.39028127
126NME10.38551947
127BMX0.38037330
128DYRK1B0.37666016
129PDK30.36056517
130PDK40.36056517
131CCNB10.34949647
132STK38L0.34159086
133CDK180.33990900
134MAP2K70.32608157
135CSNK1E0.32027329
136MATK0.29707063
137EIF2AK20.29582514
138MAP2K60.26691399
139IRAK10.25667373
140MAPK40.24002621
141ERBB20.23901124
142PRKG20.22269145
143PDK20.21541767
144ARAF0.21392166

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005312.91327842
2Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66319321
3Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.64642979
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.57110875
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.33490787
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.23091415
7Folate biosynthesis_Homo sapiens_hsa007902.17332668
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.08623442
9Proteasome_Homo sapiens_hsa030502.08147409
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06284843
11Fatty acid degradation_Homo sapiens_hsa000712.05367473
12Sulfur relay system_Homo sapiens_hsa041222.04474931
13Nitrogen metabolism_Homo sapiens_hsa009102.04403076
14Drug metabolism - other enzymes_Homo sapiens_hsa009832.03542185
15One carbon pool by folate_Homo sapiens_hsa006702.03499334
16DNA replication_Homo sapiens_hsa030302.01972852
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.99477936
18Vitamin B6 metabolism_Homo sapiens_hsa007501.97216525
19Arginine biosynthesis_Homo sapiens_hsa002201.93872986
20Biosynthesis of amino acids_Homo sapiens_hsa012301.86618294
21Ribosome_Homo sapiens_hsa030101.86391594
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.75305768
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.73868935
24Tryptophan metabolism_Homo sapiens_hsa003801.72889794
25Selenocompound metabolism_Homo sapiens_hsa004501.69630951
26Pentose phosphate pathway_Homo sapiens_hsa000301.69082814
27Carbon metabolism_Homo sapiens_hsa012001.66890672
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.66176460
29Fatty acid metabolism_Homo sapiens_hsa012121.63750075
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.62644381
31Mismatch repair_Homo sapiens_hsa034301.58524611
32Propanoate metabolism_Homo sapiens_hsa006401.58340965
33Peroxisome_Homo sapiens_hsa041461.55924993
34RNA polymerase_Homo sapiens_hsa030201.55069681
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54687120
36beta-Alanine metabolism_Homo sapiens_hsa004101.54367546
37Bladder cancer_Homo sapiens_hsa052191.53026397
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52146881
39PPAR signaling pathway_Homo sapiens_hsa033201.49817082
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45556796
41Pyrimidine metabolism_Homo sapiens_hsa002401.42229768
42Butanoate metabolism_Homo sapiens_hsa006501.40227296
43Vibrio cholerae infection_Homo sapiens_hsa051101.36591010
44Complement and coagulation cascades_Homo sapiens_hsa046101.36154889
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34087213
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31300857
47Fat digestion and absorption_Homo sapiens_hsa049751.30677344
48Chemical carcinogenesis_Homo sapiens_hsa052041.28738556
49Base excision repair_Homo sapiens_hsa034101.25509296
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23560725
51Fructose and mannose metabolism_Homo sapiens_hsa000511.22742933
52Histidine metabolism_Homo sapiens_hsa003401.22573699
53Pyruvate metabolism_Homo sapiens_hsa006201.20678505
54Spliceosome_Homo sapiens_hsa030401.18475559
55RNA transport_Homo sapiens_hsa030131.16675824
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16187164
57N-Glycan biosynthesis_Homo sapiens_hsa005101.15994873
58Glutathione metabolism_Homo sapiens_hsa004801.15493678
59Caffeine metabolism_Homo sapiens_hsa002321.14824963
60Retinol metabolism_Homo sapiens_hsa008301.14582846
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12524335
62Arginine and proline metabolism_Homo sapiens_hsa003301.12509416
63Phenylalanine metabolism_Homo sapiens_hsa003601.12481112
64Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11313516
65Pertussis_Homo sapiens_hsa051331.11058928
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09702871
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05531089
68Salmonella infection_Homo sapiens_hsa051321.05028627
69Steroid hormone biosynthesis_Homo sapiens_hsa001401.04619046
70Sphingolipid metabolism_Homo sapiens_hsa006001.02433155
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01882021
72Vitamin digestion and absorption_Homo sapiens_hsa049771.01608061
73Rheumatoid arthritis_Homo sapiens_hsa053231.01084986
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99996328
75Shigellosis_Homo sapiens_hsa051310.98800736
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98191270
77Apoptosis_Homo sapiens_hsa042100.93274913
78Sulfur metabolism_Homo sapiens_hsa009200.92036145
79Staphylococcus aureus infection_Homo sapiens_hsa051500.90315991
80Tyrosine metabolism_Homo sapiens_hsa003500.85824557
81Fatty acid biosynthesis_Homo sapiens_hsa000610.85511933
82Osteoclast differentiation_Homo sapiens_hsa043800.85426617
83Nucleotide excision repair_Homo sapiens_hsa034200.85265383
84Homologous recombination_Homo sapiens_hsa034400.85034698
85Galactose metabolism_Homo sapiens_hsa000520.81815684
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80830000
87Phagosome_Homo sapiens_hsa041450.78645296
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.78297785
89Leishmaniasis_Homo sapiens_hsa051400.77789963
90Antigen processing and presentation_Homo sapiens_hsa046120.77488451
91Glycerolipid metabolism_Homo sapiens_hsa005610.77349410
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76335792
93Fatty acid elongation_Homo sapiens_hsa000620.75745505
94Asthma_Homo sapiens_hsa053100.75664850
95TNF signaling pathway_Homo sapiens_hsa046680.72399729
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72222903
97Bile secretion_Homo sapiens_hsa049760.71890369
98Steroid biosynthesis_Homo sapiens_hsa001000.71101794
99Hepatitis C_Homo sapiens_hsa051600.70054100
100Tuberculosis_Homo sapiens_hsa051520.68304504
101Metabolic pathways_Homo sapiens_hsa011000.68028176
102Starch and sucrose metabolism_Homo sapiens_hsa005000.64558369
103Influenza A_Homo sapiens_hsa051640.64052092
104Herpes simplex infection_Homo sapiens_hsa051680.63828153
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63798282
106Legionellosis_Homo sapiens_hsa051340.59202099
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.57092092
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54151308
109Cell cycle_Homo sapiens_hsa041100.53437101
110Oxidative phosphorylation_Homo sapiens_hsa001900.53233702
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52766510
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52118353
113Purine metabolism_Homo sapiens_hsa002300.51301367
114Mineral absorption_Homo sapiens_hsa049780.51240866
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.51045959
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49872161
117Malaria_Homo sapiens_hsa051440.49372729
118Acute myeloid leukemia_Homo sapiens_hsa052210.48842376
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.48571772
120p53 signaling pathway_Homo sapiens_hsa041150.47703136
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46975633
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45602985
123Allograft rejection_Homo sapiens_hsa053300.45230081
124Collecting duct acid secretion_Homo sapiens_hsa049660.45113575
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44891588
126Lysine degradation_Homo sapiens_hsa003100.44738509
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44447627
128ABC transporters_Homo sapiens_hsa020100.43785430
129Other glycan degradation_Homo sapiens_hsa005110.38127775
130Regulation of autophagy_Homo sapiens_hsa041400.36952416
131Fanconi anemia pathway_Homo sapiens_hsa034600.34355400
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.34040331
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34034358
134Systemic lupus erythematosus_Homo sapiens_hsa053220.25559734
135Linoleic acid metabolism_Homo sapiens_hsa005910.24307228
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22083764
137Lysosome_Homo sapiens_hsa041420.21572669
138Epstein-Barr virus infection_Homo sapiens_hsa051690.20519621
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.16888934
140Renin-angiotensin system_Homo sapiens_hsa046140.15881490
141Prion diseases_Homo sapiens_hsa050200.10878515

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