ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitotic metaphase plate congression (GO:0007080)	7.30670549
2	metaphase plate congression (GO:0051310)	6.20492204
3	attachment of spindle microtubules to kinetochore (GO:0008608)	5.99625760
4	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	5.65895851
5	establishment of chromosome localization (GO:0051303)	5.58549122
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.56347743
7	piRNA metabolic process (GO:0034587)	5.43895063
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.34708966
9	mitotic chromosome condensation (GO:0007076)	5.21892744
10	meiotic cell cycle (GO:0051321)	5.13673925
11	regulation of meiosis (GO:0040020)	5.05119946
12	chaperone-mediated protein transport (GO:0072321)	5.04917004
13	meiotic chromosome segregation (GO:0045132)	4.96085205
14	regulation of exit from mitosis (GO:0007096)	4.90114758
15	female gamete generation (GO:0007292)	4.88655452
16	CENP-A containing nucleosome assembly (GO:0034080)	4.88299726
17	regulation of meiosis I (GO:0060631)	4.87942964
18	proteasome assembly (GO:0043248)	4.82999715
19	negative regulation of meiosis (GO:0045835)	4.81678438
20	ATP synthesis coupled proton transport (GO:0015986)	4.81210618
21	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.81210618
22	chromatin remodeling at centromere (GO:0031055)	4.73547583
23	protein localization to kinetochore (GO:0034501)	4.72435089
24	mitotic sister chromatid segregation (GO:0000070)	4.62713183
25	histone H2A monoubiquitination (GO:0035518)	4.58742561
26	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	4.57773892
27	regulation of spindle organization (GO:0090224)	4.51232956
28	regulation of female gonad development (GO:2000194)	4.48651517
29	male meiosis (GO:0007140)	4.44556110
30	kinetochore assembly (GO:0051382)	4.41401094
31	oocyte maturation (GO:0001556)	4.41375745
32	protein K6-linked ubiquitination (GO:0085020)	4.40943692
33	DNA replication-independent nucleosome assembly (GO:0006336)	4.38358237
34	DNA replication-independent nucleosome organization (GO:0034724)	4.38358237
35	protein localization to chromosome, centromeric region (GO:0071459)	4.37688094
36	DNA replication checkpoint (GO:0000076)	4.36038660
37	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.33200144
38	histone exchange (GO:0043486)	4.31450734
39	DNA damage induced protein phosphorylation (GO:0006975)	4.30179954
40	protein neddylation (GO:0045116)	4.24007742
41	DNA damage response, signal transduction resulting in transcription (GO:0042772)	4.23795012
42	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	4.23541652
43	regulation of sister chromatid cohesion (GO:0007063)	4.23074204
44	regulation of histone H3-K27 methylation (GO:0061085)	4.21843490
45	kinetochore organization (GO:0051383)	4.20895406
46	chromosome segregation (GO:0007059)	4.17723601
47	protein complex biogenesis (GO:0070271)	4.17281369
48	regulation of mitochondrial translation (GO:0070129)	4.14797815
49	positive regulation of chromosome segregation (GO:0051984)	4.14599087
50	regulation of mitotic spindle organization (GO:0060236)	4.13214372
51	monoubiquitinated protein deubiquitination (GO:0035520)	4.12595019
52	spindle checkpoint (GO:0031577)	4.11832046
53	mitochondrial respiratory chain complex assembly (GO:0033108)	4.10693004
54	protein localization to chromosome (GO:0034502)	4.08371183
55	regulation of DNA methylation (GO:0044030)	4.06878583
56	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	4.06340815
57	pseudouridine synthesis (GO:0001522)	4.01995092
58	respiratory electron transport chain (GO:0022904)	4.01093613
59	regulation of meiotic cell cycle (GO:0051445)	3.98167086
60	cullin deneddylation (GO:0010388)	3.97158170
61	establishment of integrated proviral latency (GO:0075713)	3.95586450
62	electron transport chain (GO:0022900)	3.92673280
63	regulation of chromosome segregation (GO:0051983)	3.87767798
64	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.87231101
65	mitotic nuclear envelope disassembly (GO:0007077)	3.84422260
66	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.83861265
67	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.83294088
68	termination of RNA polymerase III transcription (GO:0006386)	3.82630668
69	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.82630668
70	negative regulation of hormone biosynthetic process (GO:0032353)	3.81182880
71	negative regulation of hormone metabolic process (GO:0032351)	3.81182880
72	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.79617082
73	positive regulation of megakaryocyte differentiation (GO:0045654)	3.78642676
74	histone H2A ubiquitination (GO:0033522)	3.76539395
75	rRNA modification (GO:0000154)	3.76176178
76	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.75978471
77	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.74460812
78	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.74280351
79	NADH dehydrogenase complex assembly (GO:0010257)	3.74280351
80	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.74280351
81	sister chromatid segregation (GO:0000819)	3.72687469
82	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.72467980
83	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.72467980
84	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	3.72344354
85	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.71839342
86	respiratory chain complex IV assembly (GO:0008535)	3.67699244
87	DNA methylation involved in gamete generation (GO:0043046)	3.66927062
88	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.66815449
89	negative regulation of ligase activity (GO:0051352)	3.65883005
90	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.65883005
91	protein deneddylation (GO:0000338)	3.65297068
92	mitotic spindle checkpoint (GO:0071174)	3.65150827
93	cytochrome complex assembly (GO:0017004)	3.64651855
94	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.62900754
95	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.62900754
96	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.62900754
97	DNA double-strand break processing (GO:0000729)	3.61935830
98	regulation of RIG-I signaling pathway (GO:0039535)	3.61142841
99	negative regulation of meiotic cell cycle (GO:0051447)	3.59564614
100	nuclear envelope disassembly (GO:0051081)	3.58352126
101	membrane disassembly (GO:0030397)	3.58352126
102	ribosomal large subunit biogenesis (GO:0042273)	3.54189313
103	myoblast migration (GO:0051451)	3.47104195
104	chromatin assembly or disassembly (GO:0006333)	3.44056013
105	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.43548564
106	negative regulation of chromosome segregation (GO:0051985)	3.42515094
107	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.42315681
108	negative regulation of sister chromatid segregation (GO:0033046)	3.42315681
109	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.42315681
110	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.42315681
111	meiosis I (GO:0007127)	3.40227350
112	DNA ligation (GO:0006266)	3.39973892
113	regulation of cellular amino acid metabolic process (GO:0006521)	3.39565275
114	mitotic spindle assembly checkpoint (GO:0007094)	3.39043663
115	female gonad development (GO:0008585)	3.38800248
116	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.37486067
117	spliceosomal snRNP assembly (GO:0000387)	3.36525263
118	spindle assembly checkpoint (GO:0071173)	3.36037471
119	negative regulation of nuclear division (GO:0051784)	3.35291019
120	regulation of sister chromatid segregation (GO:0033045)	3.32773893
121	regulation of mitotic sister chromatid separation (GO:0010965)	3.32773893
122	regulation of mitotic sister chromatid segregation (GO:0033047)	3.32773893
123	regulation of transforming growth factor beta2 production (GO:0032909)	3.31409177
124	male meiosis I (GO:0007141)	3.31002102
125	meiotic cell cycle process (GO:1903046)	3.30246241
126	regulation of centriole replication (GO:0046599)	3.30230326
127	negative regulation of cell division (GO:0051782)	3.29759194
128	glycerophospholipid catabolic process (GO:0046475)	3.29688821
129	ribosomal small subunit assembly (GO:0000028)	3.27701102
130	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.27513932
131	meiotic nuclear division (GO:0007126)	3.26382854
132	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.26308983
133	protein targeting to mitochondrion (GO:0006626)	3.25081304
134	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.24497818
135	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.24497818
136	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.24497818
137	sister chromatid cohesion (GO:0007062)	3.24213592
138	DNA damage response, detection of DNA damage (GO:0042769)	3.22885766
139	histone mRNA metabolic process (GO:0008334)	3.22486009
140	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.21442832
141	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.21442832
142	regulation of mitotic spindle checkpoint (GO:1903504)	3.20883129
143	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.20883129
144	positive regulation of DNA-dependent DNA replication (GO:2000105)	3.20836076
145	ribosome assembly (GO:0042255)	3.20787825
146	microtubule nucleation (GO:0007020)	3.20386411
147	establishment of protein localization to mitochondrion (GO:0072655)	3.18548547
148	centriole replication (GO:0007099)	3.18497438
149	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.17980182
150	translation (GO:0006412)	3.17116433
151	replication fork processing (GO:0031297)	3.16740190
152	regulation of glucocorticoid metabolic process (GO:0031943)	3.16489638
153	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	3.16179291
154	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	3.15527903
155	positive regulation of ligase activity (GO:0051351)	3.15030918
156	inner mitochondrial membrane organization (GO:0007007)	3.13364253
157	protein localization to mitochondrion (GO:0070585)	3.13277990
158	telomere maintenance via semi-conservative replication (GO:0032201)	3.11346132
159	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.10985582
160	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.10985582
161	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.10873193
162	purine nucleobase biosynthetic process (GO:0009113)	3.07544504
163	establishment of viral latency (GO:0019043)	3.05357617
164	cotranslational protein targeting to membrane (GO:0006613)	3.04936034
165	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.03427247
166	ribosomal small subunit biogenesis (GO:0042274)	3.01626512
167	DNA catabolic process, exonucleolytic (GO:0000738)	3.00107198
168	cellular component biogenesis (GO:0044085)	2.99742093
169	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.97210065
170	* rRNA processing (GO:0006364)	2.97054726
171	maturation of SSU-rRNA (GO:0030490)	2.96956775
172	protein targeting to ER (GO:0045047)	2.96299274
173	oxidative phosphorylation (GO:0006119)	2.96051664
174	DNA strand elongation involved in DNA replication (GO:0006271)	2.95878515
175	regulation of helicase activity (GO:0051095)	2.94471978
176	DNA replication-dependent nucleosome organization (GO:0034723)	2.94405127
177	DNA replication-dependent nucleosome assembly (GO:0006335)	2.94405127
178	protein-cofactor linkage (GO:0018065)	2.92792234
179	rRNA methylation (GO:0031167)	2.90725499
180	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.90660051
181	regulation of ligase activity (GO:0051340)	2.88978202
182	7-methylguanosine mRNA capping (GO:0006370)	2.88239655
183	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.88100474
184	* rRNA metabolic process (GO:0016072)	2.87574579
185	double-strand break repair via nonhomologous end joining (GO:0006303)	2.86026325
186	non-recombinational repair (GO:0000726)	2.86026325

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.35134538
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	6.29849421
3	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	4.87570064
4	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.85376809
5	AR_21909140_ChIP-Seq_LNCAP_Human	3.76961645
6	KAP1_22055183_ChIP-Seq_ESCs_Mouse	3.31271342
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.17816477
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.12576795
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.99402503
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.88660732
11	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.54817657
12	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	2.45095779
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.36463967
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.32688411
15	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.20850282
16	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.19595546
17	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.14599091
18	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.13478967
19	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.05865755
20	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.97641388
21	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.94786114
22	VDR_22108803_ChIP-Seq_LS180_Human	1.90122170
23	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.88066467
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.86728129
25	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.84393304
26	ZNF274_21170338_ChIP-Seq_K562_Hela	1.81944716
27	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.76869386
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.74701517
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.74439655
30	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.72827172
31	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.72172991
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.69910134
33	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.69117577
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.66687831
35	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.63368008
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.62980665
37	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.61529780
38	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.61027959
39	* NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.59695416
40	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.58775133
41	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.58310390
42	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.56554201
43	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.50153762
44	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.50136874
45	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.46434620
46	VDR_23849224_ChIP-Seq_CD4+_Human	1.45227515
47	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.44686524
48	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.42253801
49	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.39878189
50	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38030970
51	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.37950815
52	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.37694037
53	FUS_26573619_Chip-Seq_HEK293_Human	1.37370103
54	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.36780590
55	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.34254256
56	* GABP_19822575_ChIP-Seq_HepG2_Human	1.33646725
57	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.31046549
58	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.25743464
59	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.25148471
60	* E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.25105701
61	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.20975865
62	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.20354708
63	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.19940384
64	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.19768304
65	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.19460792
66	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.16765664
67	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.16679127
68	KDM5A_27292631_Chip-Seq_BREAST_Human	1.16393409
69	* GATA1_26923725_Chip-Seq_HPCs_Mouse	1.14677850
70	* POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.14593752
71	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.14224607
72	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.13859411
73	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.13132396
74	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.12409788
75	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.12151098
76	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.11962878
77	IGF1R_20145208_ChIP-Seq_DFB_Human	1.11233855
78	TAF15_26573619_Chip-Seq_HEK293_Human	1.11212162
79	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.10656010
80	P300_19829295_ChIP-Seq_ESCs_Human	1.10430884
81	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.08461939
82	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.07884435
83	* KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.07691306
84	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.07264234
85	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.05966272
86	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.05395092
87	* LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04802124
88	EWS_26573619_Chip-Seq_HEK293_Human	1.04038678
89	* DCP1A_22483619_ChIP-Seq_HELA_Human	1.03175560
90	* RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.02956934
91	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02384492
92	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.99262405
93	XRN2_22483619_ChIP-Seq_HELA_Human	0.96705430
94	NANOG_18347094_ChIP-ChIP_MESCs_Mouse	0.96457405
95	IRF1_19129219_ChIP-ChIP_H3396_Human	0.96346992
96	FOXP3_21729870_ChIP-Seq_TREG_Human	0.95252345
97	TTF2_22483619_ChIP-Seq_HELA_Human	0.93461129
98	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.93280098
99	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.92019324
100	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.91673854
101	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.91600212
102	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.91297046
103	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.90925030
104	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.90696627
105	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.90556667
106	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.90509027
107	KAP1_27257070_Chip-Seq_ESCs_Mouse	0.89889363
108	HTT_18923047_ChIP-ChIP_STHdh_Human	0.88435398
109	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.87175447
110	ERG_20517297_ChIP-Seq_VCAP_Human	0.86692474
111	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.86569145
112	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.85651679
113	* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.84777971
114	RNF2_27304074_Chip-Seq_NSC_Mouse	0.84317964
115	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.84067886
116	* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.83451834
117	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.83337519
118	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.82359318
119	* STAT1_17558387_ChIP-Seq_HELA_Human	0.82322159
120	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.82014040
121	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.81605752
122	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.81104809
123	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.79841655
124	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.79666085
125	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.79392098
126	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.78837712
127	TP53_22573176_ChIP-Seq_HFKS_Human	0.78713940
128	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.78405244
129	* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.78386217
130	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.77840521
131	ELK1_19687146_ChIP-ChIP_HELA_Human	0.77815203
132	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.77516589
133	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.77046290
134	CDX2_22108803_ChIP-Seq_LS180_Human	0.76743743
135	TCF3_18692474_ChIP-Seq_MESCs_Mouse	0.76173751
136	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.75210996
137	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.75056902
138	* NANOG_19829295_ChIP-Seq_ESCs_Human	0.74602930
139	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.72241873
140	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.68652977

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	5.33598039
2	MP0003718_maternal_effect	5.06186100
3	MP0005451_abnormal_body_composition	4.83934256
4	MP0002102_abnormal_ear_morphology	4.16427240
5	MP0010094_abnormal_chromosome_stability	3.98045011
6	MP0003111_abnormal_nucleus_morphology	3.75846020
7	MP0008877_abnormal_DNA_methylation	3.69289145
8	MP0003077_abnormal_cell_cycle	3.65746023
9	MP0003646_muscle_fatigue	3.63175356
10	MP0004957_abnormal_blastocyst_morpholog	3.47146199
11	MP0002653_abnormal_ependyma_morphology	3.16916171
12	MP0003123_paternal_imprinting	2.70679244
13	MP0002938_white_spotting	2.60870452
14	MP0005408_hypopigmentation	2.49153130
15	MP0001119_abnormal_female_reproductive	2.39250385
16	MP0008007_abnormal_cellular_replicative	2.36267462
17	MP0006292_abnormal_olfactory_placode	2.34319847
18	MP0008932_abnormal_embryonic_tissue	2.30729135
19	MP0003941_abnormal_skin_development	2.30381994
20	MP0008057_abnormal_DNA_replication	2.24496675
21	MP0005395_other_phenotype	2.24222672
22	MP0003699_abnormal_female_reproductive	2.15305163
23	MP0008058_abnormal_DNA_repair	2.13418439
24	MP0001929_abnormal_gametogenesis	2.10877255
25	MP0003806_abnormal_nucleotide_metabolis	2.10395400
26	MP0002210_abnormal_sex_determination	2.09966334
27	MP0000653_abnormal_sex_gland	2.07355193
28	MP0003787_abnormal_imprinting	1.98811368
29	MP0003121_genomic_imprinting	1.88650444
30	MP0006035_abnormal_mitochondrial_morpho	1.87261305
31	MP0001293_anophthalmia	1.84320851
32	MP0008789_abnormal_olfactory_epithelium	1.82556003
33	MP0001529_abnormal_vocalization	1.81215610
34	MP0003937_abnormal_limbs/digits/tail_de	1.79888540
35	MP0000350_abnormal_cell_proliferation	1.74721790
36	MP0001730_embryonic_growth_arrest	1.74461571
37	MP0009379_abnormal_foot_pigmentation	1.73646675
38	MP0006036_abnormal_mitochondrial_physio	1.60915817
39	MP0001145_abnormal_male_reproductive	1.59738789
40	MP0000372_irregular_coat_pigmentation	1.58500651
41	MP0002249_abnormal_larynx_morphology	1.56147286
42	MP0002085_abnormal_embryonic_tissue	1.54461448
43	MP0005084_abnormal_gallbladder_morpholo	1.53134611
44	MP0001697_abnormal_embryo_size	1.52238159
45	MP0003315_abnormal_perineum_morphology	1.44040602
46	MP0002638_abnormal_pupillary_reflex	1.43891325
47	MP0003136_yellow_coat_color	1.40217409
48	MP0002234_abnormal_pharynx_morphology	1.39570298
49	MP0003567_abnormal_fetal_cardiomyocyte	1.37665426
50	MP0003011_delayed_dark_adaptation	1.36637379
51	MP0002736_abnormal_nociception_after	1.29973601
52	MP0002084_abnormal_developmental_patter	1.27758159
53	MP0001672_abnormal_embryogenesis/_devel	1.27317185
54	MP0005380_embryogenesis_phenotype	1.27317185
55	MP0002161_abnormal_fertility/fecundity	1.25878090
56	MP0001764_abnormal_homeostasis	1.24684163
57	MP0004147_increased_porphyrin_level	1.24132078
58	MP0003950_abnormal_plasma_membrane	1.22029261
59	MP0000579_abnormal_nail_morphology	1.21297428
60	MP0000462_abnormal_digestive_system	1.21283439
61	MP0001188_hyperpigmentation	1.20158326
62	MP0005394_taste/olfaction_phenotype	1.19233272
63	MP0005499_abnormal_olfactory_system	1.19233272
64	MP0005253_abnormal_eye_physiology	1.17859858
65	MP0003122_maternal_imprinting	1.17315923
66	MP0004264_abnormal_extraembryonic_tissu	1.15423121
67	MP0004133_heterotaxia	1.14867386
68	MP0002837_dystrophic_cardiac_calcinosis	1.14071415
69	MP0002751_abnormal_autonomic_nervous	1.11807600
70	MP0001915_intracranial_hemorrhage	1.10411280
71	MP0002019_abnormal_tumor_incidence	1.09724666
72	MP0001286_abnormal_eye_development	1.09492933
73	MP0003786_premature_aging	1.07730312
74	MP0001905_abnormal_dopamine_level	1.06565362
75	MP0005551_abnormal_eye_electrophysiolog	1.05908295
76	MP0000647_abnormal_sebaceous_gland	1.04010600
77	MP0002277_abnormal_respiratory_mucosa	1.03507300
78	MP0005310_abnormal_salivary_gland	1.02923127
79	MP0000490_abnormal_crypts_of	1.02496673
80	MP0000631_abnormal_neuroendocrine_gland	1.01650007
81	MP0003880_abnormal_central_pattern	1.00520501
82	MP0003119_abnormal_digestive_system	0.98839831
83	MP0001984_abnormal_olfaction	0.98364149
84	MP0003984_embryonic_growth_retardation	0.96525702
85	MP0000358_abnormal_cell_content/	0.96160893
86	MP0010307_abnormal_tumor_latency	0.96011158
87	MP0004142_abnormal_muscle_tone	0.94842253
88	MP0002396_abnormal_hematopoietic_system	0.94224152
89	MP0000639_abnormal_adrenal_gland	0.94149086
90	MP0001485_abnormal_pinna_reflex	0.93274038
91	MP0003890_abnormal_embryonic-extraembry	0.92502997
92	MP0002088_abnormal_embryonic_growth/wei	0.91214995
93	MP0000569_abnormal_digit_pigmentation	0.91074658
94	MP0002080_prenatal_lethality	0.90430404
95	MP0000049_abnormal_middle_ear	0.90209296
96	MP0003698_abnormal_male_reproductive	0.90148620
97	MP0003755_abnormal_palate_morphology	0.88828753
98	MP0002090_abnormal_vision	0.87524001
99	MP0009046_muscle_twitch	0.87012674
100	MP0001851_eye_inflammation	0.86000615
101	MP0003195_calcinosis	0.85853445
102	MP0004215_abnormal_myocardial_fiber	0.85435444
103	MP0010368_abnormal_lymphatic_system	0.85415505
104	MP0008260_abnormal_autophagy	0.84607289
105	MP0005646_abnormal_pituitary_gland	0.83662571
106	MP0002163_abnormal_gland_morphology	0.83578565
107	MP0002095_abnormal_skin_pigmentation	0.83049804
108	MP0002086_abnormal_extraembryonic_tissu	0.82856274
109	MP0005621_abnormal_cell_physiology	0.82152123
110	MP0004185_abnormal_adipocyte_glucose	0.80623115
111	MP0000313_abnormal_cell_death	0.79552791
112	MP0005379_endocrine/exocrine_gland_phen	0.79256924
113	MP0001324_abnormal_eye_pigmentation	0.77714253
114	MP0000566_synostosis	0.76185520
115	MP0005075_abnormal_melanosome_morpholog	0.75707986
116	MP0002111_abnormal_tail_morphology	0.75700821
117	MP0005391_vision/eye_phenotype	0.74652624
118	MP0009250_abnormal_appendicular_skeleto	0.71919055
119	MP0002877_abnormal_melanocyte_morpholog	0.71076830
120	MP0005389_reproductive_system_phenotype	0.71014698
121	MP0002697_abnormal_eye_size	0.70196295
122	MP0002282_abnormal_trachea_morphology	0.69293366
123	MP0009333_abnormal_splenocyte_physiolog	0.68718188
124	MP0000432_abnormal_head_morphology	0.68375874
125	MP0005384_cellular_phenotype	0.65446599
126	MP0001849_ear_inflammation	0.65196685
127	MP0009697_abnormal_copulation	0.65123033
128	MP0001919_abnormal_reproductive_system	0.63194228
129	MP0002177_abnormal_outer_ear	0.61220423
130	MP0000427_abnormal_hair_cycle	0.60809084
131	MP0004145_abnormal_muscle_electrophysio	0.60105708
132	MP0002116_abnormal_craniofacial_bone	0.60098312
133	MP0010030_abnormal_orbit_morphology	0.59346060
134	MP0010386_abnormal_urinary_bladder	0.57013606
135	MP0003861_abnormal_nervous_system	0.56152123
136	MP0003763_abnormal_thymus_physiology	0.55995077
137	MP0003186_abnormal_redox_activity	0.55817130
138	MP0004782_abnormal_surfactant_physiolog	0.55257181
139	MP0000613_abnormal_salivary_gland	0.54224266
140	MP0003936_abnormal_reproductive_system	0.52634848
141	MP0006072_abnormal_retinal_apoptosis	0.52017448
142	MP0002233_abnormal_nose_morphology	0.51905634
143	MP0002160_abnormal_reproductive_system	0.50942437
144	MP0005647_abnormal_sex_gland	0.50842255
145	MP0003453_abnormal_keratinocyte_physiol	0.50235976
146	MP0008995_early_reproductive_senescence	0.50217274
147	MP0003656_abnormal_erythrocyte_physiolo	0.48113553
148	MP0005076_abnormal_cell_differentiation	0.47974435
149	MP0002114_abnormal_axial_skeleton	0.47579656
150	MP0002109_abnormal_limb_morphology	0.46993573
151	MP0000627_abnormal_mammary_gland	0.46573980
152	MP0005508_abnormal_skeleton_morphology	0.44862359

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Male infertility (HP:0003251)	6.83978678
2	Birth length less than 3rd percentile (HP:0003561)	6.06985910
3	Chromsome breakage (HP:0040012)	5.42563016
4	Breast hypoplasia (HP:0003187)	5.28118096
5	Acute necrotizing encephalopathy (HP:0006965)	5.11909381
6	Papillary thyroid carcinoma (HP:0002895)	5.02419243
7	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.85934587
8	Patellar aplasia (HP:0006443)	4.54432570
9	Abnormal mitochondria in muscle tissue (HP:0008316)	4.46923016
10	Acute encephalopathy (HP:0006846)	4.46493397
11	Abnormality of the labia minora (HP:0012880)	4.43333552
12	Progressive macrocephaly (HP:0004481)	4.28439217
13	Mitochondrial inheritance (HP:0001427)	4.24817848
14	Aplasia/Hypoplasia of the patella (HP:0006498)	4.19108642
15	Increased hepatocellular lipid droplets (HP:0006565)	4.18441322
16	Increased CSF lactate (HP:0002490)	4.07152590
17	Facial hemangioma (HP:0000329)	3.99440145
18	Adrenal hypoplasia (HP:0000835)	3.92821563
19	Lipid accumulation in hepatocytes (HP:0006561)	3.84079774
20	Shawl scrotum (HP:0000049)	3.71099850
21	Flat capital femoral epiphysis (HP:0003370)	3.67791573
22	Capillary hemangiomas (HP:0005306)	3.54594852
23	Hepatocellular necrosis (HP:0001404)	3.43326350
24	Secondary amenorrhea (HP:0000869)	3.41878050
25	Abnormality of chromosome stability (HP:0003220)	3.41020051
26	Cerebral edema (HP:0002181)	3.39215558
27	Hepatic necrosis (HP:0002605)	3.29156420
28	Breast aplasia (HP:0100783)	3.22522150
29	Renal Fanconi syndrome (HP:0001994)	3.21939643
30	Aplasia/Hypoplasia of the breasts (HP:0010311)	3.15671504
31	Carpal bone hypoplasia (HP:0001498)	3.10379359
32	Supernumerary spleens (HP:0009799)	3.06844229
33	Abnormality of the preputium (HP:0100587)	3.05685277
34	Meckel diverticulum (HP:0002245)	2.99764848
35	Premature ovarian failure (HP:0008209)	2.98902931
36	Methylmalonic acidemia (HP:0002912)	2.97898462
37	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.93171644
38	Absent radius (HP:0003974)	2.87849796
39	Acute myeloid leukemia (HP:0004808)	2.86859685
40	Oligodactyly (hands) (HP:0001180)	2.83622868
41	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.83002208
42	Thyroid carcinoma (HP:0002890)	2.81437484
43	Abnormality of the ileum (HP:0001549)	2.79865859
44	Cortical dysplasia (HP:0002539)	2.77898905
45	Aplasia involving forearm bones (HP:0009822)	2.75165344
46	Absent forearm bone (HP:0003953)	2.75165344
47	Increased serum lactate (HP:0002151)	2.74634351
48	Abnormality of lateral ventricle (HP:0030047)	2.68330705
49	Pulmonary fibrosis (HP:0002206)	2.67032168
50	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.64298580
51	3-Methylglutaconic aciduria (HP:0003535)	2.63762859
52	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.60243610
53	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.60243610
54	Leukodystrophy (HP:0002415)	2.58590116
55	Pancreatic fibrosis (HP:0100732)	2.58215582
56	Macrocytic anemia (HP:0001972)	2.58214442
57	Aplastic anemia (HP:0001915)	2.56949744
58	Oligodactyly (HP:0012165)	2.55869001
59	Colon cancer (HP:0003003)	2.55589848
60	Abnormal number of erythroid precursors (HP:0012131)	2.55067671
61	Lactic acidosis (HP:0003128)	2.53857069
62	Increased serum pyruvate (HP:0003542)	2.53657622
63	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.53607128
64	Duodenal stenosis (HP:0100867)	2.51018237
65	Small intestinal stenosis (HP:0012848)	2.51018237
66	Hypergonadotropic hypogonadism (HP:0000815)	2.47559800
67	Myelodysplasia (HP:0002863)	2.47187939
68	Abnormality of cells of the erythroid lineage (HP:0012130)	2.47168626
69	Respiratory failure (HP:0002878)	2.46682567
70	Type I transferrin isoform profile (HP:0003642)	2.43618219
71	Abnormality of chromosome segregation (HP:0002916)	2.41539000
72	Oral leukoplakia (HP:0002745)	2.41511463
73	Type 2 muscle fiber atrophy (HP:0003554)	2.41377836
74	Sandal gap (HP:0001852)	2.41035876
75	Exertional dyspnea (HP:0002875)	2.38975956
76	Ectopic kidney (HP:0000086)	2.38371131
77	Irregular epiphyses (HP:0010582)	2.37068370
78	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.36110843
79	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.35395976
80	Methylmalonic aciduria (HP:0012120)	2.34498749
81	Abnormality of the fingertips (HP:0001211)	2.34008956
82	Congenital, generalized hypertrichosis (HP:0004540)	2.33521469
83	Sloping forehead (HP:0000340)	2.33100483
84	Short thumb (HP:0009778)	2.32801707
85	True hermaphroditism (HP:0010459)	2.30086526
86	Increased intramyocellular lipid droplets (HP:0012240)	2.30054974
87	Molar tooth sign on MRI (HP:0002419)	2.29639603
88	Abnormality of midbrain morphology (HP:0002418)	2.29639603
89	Abnormality of renal resorption (HP:0011038)	2.29484908
90	Prostate neoplasm (HP:0100787)	2.28108807
91	Abnormality of methionine metabolism (HP:0010901)	2.27402335
92	Pancreatic cysts (HP:0001737)	2.26528177
93	Cerebral hypomyelination (HP:0006808)	2.26451252
94	Respiratory difficulties (HP:0002880)	2.26420354
95	Optic disc pallor (HP:0000543)	2.26067885
96	Muscle fiber atrophy (HP:0100295)	2.25756553
97	Exercise intolerance (HP:0003546)	2.24932629
98	Lethargy (HP:0001254)	2.23129866
99	Reticulocytopenia (HP:0001896)	2.21917799
100	Volvulus (HP:0002580)	2.19813809
101	Arterial tortuosity (HP:0005116)	2.19253704
102	Cystic hygroma (HP:0000476)	2.18069694
103	Abnormality of glycolysis (HP:0004366)	2.17696792
104	Septo-optic dysplasia (HP:0100842)	2.17574714
105	Abnormal spermatogenesis (HP:0008669)	2.14866224
106	Fibular aplasia (HP:0002990)	2.14597292
107	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.13683600
108	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.11964097
109	Chronic bronchitis (HP:0004469)	2.11543754
110	Renal cortical cysts (HP:0000803)	2.11404474
111	Medial flaring of the eyebrow (HP:0010747)	2.10840648
112	Abnormality of alanine metabolism (HP:0010916)	2.09561325
113	Hyperalaninemia (HP:0003348)	2.09561325
114	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.09561325
115	Clubbing of toes (HP:0100760)	2.06998248
116	Spondylolisthesis (HP:0003302)	2.06899605
117	Infertility (HP:0000789)	2.05693705
118	Hyperglycinemia (HP:0002154)	2.05600677
119	Nephroblastoma (Wilms tumor) (HP:0002667)	2.04787804
120	Overlapping toe (HP:0001845)	2.03768534
121	Abnormality of the femoral head (HP:0003368)	2.02851161
122	Wrist flexion contracture (HP:0001239)	2.02698766
123	Abnormal protein glycosylation (HP:0012346)	2.02550212
124	Abnormal glycosylation (HP:0012345)	2.02550212
125	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.02550212
126	Abnormal protein N-linked glycosylation (HP:0012347)	2.02550212
127	Impulsivity (HP:0100710)	2.01660188
128	Intestinal atresia (HP:0011100)	1.99478839
129	Abnormality of the duodenum (HP:0002246)	1.99156629
130	Abnormality of the phalanges of the hallux (HP:0010057)	1.99029915
131	CNS demyelination (HP:0007305)	1.98429595
132	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.97629568
133	Abnormality of serum amino acid levels (HP:0003112)	1.97078915
134	Primary amenorrhea (HP:0000786)	1.96952654
135	Horseshoe kidney (HP:0000085)	1.96565637
136	Sparse lateral eyebrow (HP:0005338)	1.96125434
137	Abnormal lung lobation (HP:0002101)	1.95621346
138	Abnormality of femoral epiphyses (HP:0006499)	1.95327976
139	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.95327976
140	Nephronophthisis (HP:0000090)	1.91095061
141	Azoospermia (HP:0000027)	1.91032350
142	Lip pit (HP:0100267)	1.90898826
143	Abnormality of placental membranes (HP:0011409)	1.90805750
144	Amniotic constriction ring (HP:0009775)	1.90805750
145	Bone marrow hypocellularity (HP:0005528)	1.89600468
146	Embryonal renal neoplasm (HP:0011794)	1.88809460
147	Hypoplastic iliac wings (HP:0002866)	1.88344736
148	Abnormality of the anterior horn cell (HP:0006802)	1.86727137
149	Degeneration of anterior horn cells (HP:0002398)	1.86727137
150	Rib fusion (HP:0000902)	1.86592954
151	Glycosuria (HP:0003076)	1.86265022
152	Abnormality of urine glucose concentration (HP:0011016)	1.86265022
153	Rhabdomyosarcoma (HP:0002859)	1.86013001
154	Reduced antithrombin III activity (HP:0001976)	1.85299654
155	Vascular tortuosity (HP:0004948)	1.84779590
156	Bifid tongue (HP:0010297)	1.83329983
157	Abnormality of the clitoris (HP:0000056)	1.83286649
158	Pancytopenia (HP:0001876)	1.82441121
159	Abnormality of the carotid arteries (HP:0005344)	1.81637092
160	Triphalangeal thumb (HP:0001199)	1.80540344
161	Cafe-au-lait spot (HP:0000957)	1.79231133
162	Medulloblastoma (HP:0002885)	1.78762265
163	X-linked dominant inheritance (HP:0001423)	1.78426321
164	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.78377144
165	Congenital primary aphakia (HP:0007707)	1.78143110
166	CNS hypomyelination (HP:0003429)	1.77183221
167	Megaloblastic anemia (HP:0001889)	1.76960562
168	Neoplasm of the oral cavity (HP:0100649)	1.76797242
169	Hypoplasia of the pons (HP:0012110)	1.76292979
170	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.76126104
171	Pendular nystagmus (HP:0012043)	1.75758013
172	Generalized aminoaciduria (HP:0002909)	1.75750837
173	Increased muscle lipid content (HP:0009058)	1.75514389
174	Abnormality of the fovea (HP:0000493)	1.73273740
175	Sparse eyelashes (HP:0000653)	1.73064923
176	Abnormality of the pons (HP:0007361)	1.72830735
177	Nonprogressive disorder (HP:0003680)	1.72818248
178	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.71634974
179	Gait imbalance (HP:0002141)	1.69957467

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	4.12866285
2	LATS1	3.97674366
3	MAP3K6	3.78772579
4	LATS2	3.50280852
5	CDC7	3.35697060
6	STK38L	3.33858315
7	MUSK	3.13397388
8	TTK	3.08520369
9	VRK2	3.04839072
10	ERBB4	2.98314445
11	MST4	2.96594093
12	BRAF	2.80801557
13	MOS	2.73458040
14	TAOK3	2.69112884
15	KSR2	2.58357159
16	NME1	2.56676691
17	PBK	2.53079777
18	TRIM28	2.47027814
19	ARAF	2.26157993
20	RAF1	2.21849085
21	MAP3K9	2.20999048
22	WNK3	2.13111079
23	STK16	2.12498784
24	TSSK6	2.09391320
25	BUB1	1.99155656
26	BMPR2	1.97612828
27	MAP3K13	1.96718151
28	EEF2K	1.91799324
29	ZAK	1.90675720
30	TAOK1	1.84879692
31	NEK2	1.71657175
32	PLK1	1.69972840
33	CDK8	1.66751257
34	CHEK2	1.65630776
35	MAPKAPK3	1.62874755
36	MELK	1.60536259
37	STK3	1.55906728
38	TNIK	1.52256710
39	DYRK2	1.39614170
40	MAP4K2	1.37958377
41	BCR	1.36820329
42	BRSK2	1.35424996
43	ACVR1B	1.34615946
44	EIF2AK1	1.31592983
45	WEE1	1.26708941
46	CDK9	1.24908351
47	SRPK1	1.22909779
48	PLK3	1.22191885
49	ERBB3	1.17743077
50	PNCK	1.15095479
51	STK10	1.13018465
52	KSR1	1.11899280
53	TAF1	1.11417953
54	AURKB	1.10758902
55	NUAK1	1.07008677
56	MAP3K8	1.06885569
57	MAP3K12	1.04555186
58	VRK1	1.04457704
59	NME2	1.02684492
60	PAK6	0.97466141
61	EIF2AK2	0.95906782
62	ABL2	0.93824692
63	BRSK1	0.93773371
64	GRK1	0.93420097
65	PRKD3	0.93411763
66	AURKA	0.93264480
67	PDK2	0.89857177
68	ADRBK2	0.83352074
69	BCKDK	0.82760757
70	PRKCG	0.81877917
71	FRK	0.81032087
72	MAPK13	0.79183793
73	MAP3K4	0.78596151
74	MAPKAPK5	0.77088776
75	CASK	0.76088319
76	CHEK1	0.73945295
77	RPS6KB2	0.72768638
78	INSRR	0.71720532
79	CSNK2A2	0.69783335
80	DMPK	0.67627448
81	CSNK2A1	0.67215793
82	CDK7	0.66533372
83	ATM	0.65321457
84	CCNB1	0.63209865
85	STK24	0.62863705
86	STK39	0.62726905
87	CSNK1G1	0.61405180
88	MAP2K7	0.60729320
89	WNK4	0.58961052
90	TYRO3	0.57815865
91	CDK3	0.56351151
92	PRKCE	0.56124253
93	TRPM7	0.55216781
94	ATR	0.55017763
95	PAK4	0.52322319
96	PRKD2	0.52101753
97	CSNK1E	0.51780018
98	OXSR1	0.50733096
99	NLK	0.50712365
100	TGFBR1	0.50167884
101	STK38	0.50100002
102	PASK	0.48589815
103	NEK1	0.48060754
104	FGFR1	0.47702340
105	MAP3K5	0.47364844
106	NEK9	0.47296743
107	LIMK1	0.47059583
108	BMPR1B	0.46726364
109	MINK1	0.46392590
110	CSNK1G3	0.45490718
111	MKNK2	0.44368548
112	CSNK1G2	0.42013490
113	CDK1	0.41213386
114	CDK2	0.41015920
115	TLK1	0.40956606
116	EIF2AK3	0.40950459
117	RIPK1	0.40293816
118	RPS6KA4	0.40238680
119	DAPK1	0.38287696
120	CDK4	0.37472698
121	TESK2	0.37302775
122	CSNK1A1	0.36675951
123	PRKAA2	0.36263983
124	PRKAA1	0.35179916
125	YES1	0.35157092
126	STK4	0.34028748
127	PAK1	0.33046795
128	DYRK3	0.32683746
129	NEK6	0.32204697
130	PLK2	0.30903653
131	ALK	0.30019860
132	EPHA4	0.29836379
133	DAPK3	0.29493404
134	ILK	0.29109103
135	MARK2	0.27182681
136	PRKCI	0.27084252
137	PAK3	0.26448327
138	JAK3	0.26345199
139	RET	0.24590917
140	CSNK1A1L	0.24117669
141	SGK2	0.23451063
142	ABL1	0.23441775
143	MKNK1	0.22091726
144	CDK12	0.21132633
145	MAP2K4	0.19280233
146	PINK1	0.15686049
147	PIM1	0.15525551
148	CAMK2A	0.13597271
149	CHUK	0.12575399

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cell cycle_Homo sapiens_hsa04110	4.56396311
2	Basal transcription factors_Homo sapiens_hsa03022	4.00385942
3	RNA polymerase_Homo sapiens_hsa03020	3.72050640
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.62920874
5	Ribosome_Homo sapiens_hsa03010	3.45507941
6	* RNA degradation_Homo sapiens_hsa03018	3.25285523
7	Homologous recombination_Homo sapiens_hsa03440	3.24805202
8	DNA replication_Homo sapiens_hsa03030	3.18682488
9	Parkinsons disease_Homo sapiens_hsa05012	3.16541713
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.92348229
11	Mismatch repair_Homo sapiens_hsa03430	2.80226403
12	RNA transport_Homo sapiens_hsa03013	2.80173073
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.67934074
14	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.47259927
15	Base excision repair_Homo sapiens_hsa03410	2.42225982
16	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.33872778
17	Nucleotide excision repair_Homo sapiens_hsa03420	2.33485084
18	Non-homologous end-joining_Homo sapiens_hsa03450	2.31969847
19	p53 signaling pathway_Homo sapiens_hsa04115	2.26607747
20	Oocyte meiosis_Homo sapiens_hsa04114	2.25794436
21	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.10854927
22	Circadian rhythm_Homo sapiens_hsa04710	2.07136645
23	Alzheimers disease_Homo sapiens_hsa05010	2.02017769
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.91818387
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.90316325
26	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.86194166
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.81268988
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.75481315
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.69167524
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.64304266
31	Spliceosome_Homo sapiens_hsa03040	1.61813997
32	Pancreatic cancer_Homo sapiens_hsa05212	1.60747828
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.55171419
34	mRNA surveillance pathway_Homo sapiens_hsa03015	1.49652864
35	Propanoate metabolism_Homo sapiens_hsa00640	1.44762607
36	Steroid biosynthesis_Homo sapiens_hsa00100	1.40484352
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.33991831
38	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.31584828
39	Purine metabolism_Homo sapiens_hsa00230	1.25080937
40	MicroRNAs in cancer_Homo sapiens_hsa05206	1.23427936
41	Fatty acid elongation_Homo sapiens_hsa00062	1.22115903
42	Pyruvate metabolism_Homo sapiens_hsa00620	1.17846541
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.17297566
44	One carbon pool by folate_Homo sapiens_hsa00670	1.14784219
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11501425
46	Colorectal cancer_Homo sapiens_hsa05210	1.11050956
47	Thyroid cancer_Homo sapiens_hsa05216	0.97364362
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.97254835
49	Folate biosynthesis_Homo sapiens_hsa00790	0.91034564
50	Protein export_Homo sapiens_hsa03060	0.87891542
51	Butanoate metabolism_Homo sapiens_hsa00650	0.87280023
52	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.86295370
53	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.85318594
54	Prolactin signaling pathway_Homo sapiens_hsa04917	0.84350583
55	Hippo signaling pathway_Homo sapiens_hsa04390	0.83638627
56	Proteasome_Homo sapiens_hsa03050	0.82931135
57	Peroxisome_Homo sapiens_hsa04146	0.82600255
58	Herpes simplex infection_Homo sapiens_hsa05168	0.79465849
59	Sulfur relay system_Homo sapiens_hsa04122	0.78003756
60	Choline metabolism in cancer_Homo sapiens_hsa05231	0.77077206
61	GnRH signaling pathway_Homo sapiens_hsa04912	0.75847544
62	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.75001791
63	Metabolic pathways_Homo sapiens_hsa01100	0.74195070
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74070654
65	Renal cell carcinoma_Homo sapiens_hsa05211	0.73141597
66	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.71088209
67	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.70609386
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.69927485
69	Selenocompound metabolism_Homo sapiens_hsa00450	0.69336902
70	Phototransduction_Homo sapiens_hsa04744	0.69114441
71	Other glycan degradation_Homo sapiens_hsa00511	0.68504835
72	Adherens junction_Homo sapiens_hsa04520	0.66696350
73	HTLV-I infection_Homo sapiens_hsa05166	0.66331055
74	FoxO signaling pathway_Homo sapiens_hsa04068	0.65100311
75	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.64034948
76	Small cell lung cancer_Homo sapiens_hsa05222	0.62754788
77	Tyrosine metabolism_Homo sapiens_hsa00350	0.62154603
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.59018616
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57491285
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.55579696
81	Sphingolipid metabolism_Homo sapiens_hsa00600	0.55205366
82	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.54407176
83	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.51853163
84	Shigellosis_Homo sapiens_hsa05131	0.51701761
85	Tryptophan metabolism_Homo sapiens_hsa00380	0.51348304
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.51198267
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.50437326
88	Hepatitis B_Homo sapiens_hsa05161	0.49922452
89	Endometrial cancer_Homo sapiens_hsa05213	0.49101543
90	Viral carcinogenesis_Homo sapiens_hsa05203	0.48580841
91	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.48213727
92	Fatty acid degradation_Homo sapiens_hsa00071	0.48197547
93	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47907460
94	Carbon metabolism_Homo sapiens_hsa01200	0.46643442
95	Sulfur metabolism_Homo sapiens_hsa00920	0.45762912
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45527461
97	VEGF signaling pathway_Homo sapiens_hsa04370	0.45377078
98	Notch signaling pathway_Homo sapiens_hsa04330	0.44806616
99	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44634153
100	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.42724158
101	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.42368529
102	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.40566083
103	Prostate cancer_Homo sapiens_hsa05215	0.39701509
104	Retinol metabolism_Homo sapiens_hsa00830	0.39517514
105	Ras signaling pathway_Homo sapiens_hsa04014	0.39282884
106	Chemical carcinogenesis_Homo sapiens_hsa05204	0.39191897
107	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.37369936
108	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36824543
109	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.35957688
110	Long-term depression_Homo sapiens_hsa04730	0.35917290
111	Caffeine metabolism_Homo sapiens_hsa00232	0.35671410
112	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35279315
113	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34856155
114	Glutathione metabolism_Homo sapiens_hsa00480	0.33832970
115	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.32767798
116	Olfactory transduction_Homo sapiens_hsa04740	0.32240688
117	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.31413275
118	Bladder cancer_Homo sapiens_hsa05219	0.30017392
119	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.30007782
120	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.28796638
121	Wnt signaling pathway_Homo sapiens_hsa04310	0.28725370
122	Pathways in cancer_Homo sapiens_hsa05200	0.28481453
123	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.27187210
124	Non-small cell lung cancer_Homo sapiens_hsa05223	0.26882906
125	Nicotine addiction_Homo sapiens_hsa05033	0.26628168
126	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.25131187
127	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.24470741
128	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.23220350
129	Tight junction_Homo sapiens_hsa04530	0.22379208
130	Arginine and proline metabolism_Homo sapiens_hsa00330	0.22179492
131	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.22030433
132	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.21615032
133	Huntingtons disease_Homo sapiens_hsa05016	0.21259863
134	MAPK signaling pathway_Homo sapiens_hsa04010	0.21118485
135	Basal cell carcinoma_Homo sapiens_hsa05217	0.20754364
136	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.20441953
137	mTOR signaling pathway_Homo sapiens_hsa04150	0.19456216
138	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.18956289
139	Influenza A_Homo sapiens_hsa05164	0.18669533
140	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.17648654
141	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.17157784
142	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.16969286
143	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.16770250
144	Regulation of autophagy_Homo sapiens_hsa04140	0.16002516
145	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.15928018
146	Fat digestion and absorption_Homo sapiens_hsa04975	0.15311869
147	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.15287184
148	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.14854806
149	Melanoma_Homo sapiens_hsa05218	0.14285283
150	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.14178691
151	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.13932156
152	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.13778527
153	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.13238849
154	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.12921493
155	Nitrogen metabolism_Homo sapiens_hsa00910	0.12915575

MPHOSPH6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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