MPHOSPH8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ectoderm development (GO:0007398)9.02773070
2glyoxylate metabolic process (GO:0046487)8.97247700
3female gonad development (GO:0008585)6.98137461
4regulation of telomere maintenance via telomerase (GO:0032210)6.46152729
5central nervous system neuron axonogenesis (GO:0021955)6.18153130
6negative regulation of telomere maintenance (GO:0032205)6.08553289
7regulation of protein glycosylation (GO:0060049)5.87010582
8negative regulation of glycoprotein biosynthetic process (GO:0010561)5.39109339
9stress granule assembly (GO:0034063)5.27752713
10thyroid hormone generation (GO:0006590)5.27289632
11inner mitochondrial membrane organization (GO:0007007)5.16556650
12cranial suture morphogenesis (GO:0060363)5.11818737
13phospholipid translocation (GO:0045332)4.73392031
14lipid translocation (GO:0034204)4.73392031
15thyroid hormone metabolic process (GO:0042403)4.67451751
16ventricular trabecula myocardium morphogenesis (GO:0003222)4.66885642
17regulation of natural killer cell mediated immunity (GO:0002715)4.61456061
18regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.61456061
19response to hepatocyte growth factor (GO:0035728)4.56409814
20cellular response to hepatocyte growth factor stimulus (GO:0035729)4.56409814
21centrosome duplication (GO:0051298)4.52209745
22regulation of G0 to G1 transition (GO:0070316)4.47302180
23negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.42457219
24peptidyl-lysine dimethylation (GO:0018027)4.30243393
25piRNA metabolic process (GO:0034587)4.28351684
26establishment of protein localization to mitochondrial membrane (GO:0090151)4.22722237
27positive regulation of keratinocyte differentiation (GO:0045618)4.15466048
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.07016125
29apoptotic DNA fragmentation (GO:0006309)4.05835686
30intermediate filament cytoskeleton organization (GO:0045104)4.03579537
31intermediate filament-based process (GO:0045103)3.98395869
32negative regulation of glycoprotein metabolic process (GO:1903019)3.97746749
33regulation of voltage-gated calcium channel activity (GO:1901385)3.96734178
34maintenance of protein location in nucleus (GO:0051457)3.87047000
35ATP synthesis coupled proton transport (GO:0015986)3.85659325
36energy coupled proton transport, down electrochemical gradient (GO:0015985)3.85659325
37heart trabecula morphogenesis (GO:0061384)3.80882927
38neuron cell-cell adhesion (GO:0007158)3.80546246
39mast cell activation (GO:0045576)3.79153356
40DNA methylation involved in gamete generation (GO:0043046)3.72918303
41establishment of integrated proviral latency (GO:0075713)3.67612473
42somatic hypermutation of immunoglobulin genes (GO:0016446)3.64410846
43somatic diversification of immune receptors via somatic mutation (GO:0002566)3.64410846
44RNA destabilization (GO:0050779)3.64095093
45histone H3-K4 trimethylation (GO:0080182)3.61993683
46regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.61416766
47regulation of telomere maintenance (GO:0032204)3.60858161
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.57811422
49negative regulation of keratinocyte proliferation (GO:0010839)3.56354429
50protein neddylation (GO:0045116)3.54286025
51cellular potassium ion homeostasis (GO:0030007)3.49375890
52chaperone-mediated protein transport (GO:0072321)3.47972385
53cellular response to thyroid hormone stimulus (GO:0097067)3.45370230
54DNA strand renaturation (GO:0000733)3.45174803
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.37612767
56hydrogen peroxide biosynthetic process (GO:0050665)3.36427045
57central nervous system myelination (GO:0022010)3.35468792
58axon ensheathment in central nervous system (GO:0032291)3.35468792
59regulation of meiosis I (GO:0060631)3.35167496
60galactose metabolic process (GO:0006012)3.34331603
61negative regulation of translation, ncRNA-mediated (GO:0040033)3.30205785
62regulation of translation, ncRNA-mediated (GO:0045974)3.30205785
63negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.30205785
64male meiosis (GO:0007140)3.29843038
65positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.25633771
66mitotic G2 DNA damage checkpoint (GO:0007095)3.23214603
67SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.22359637
68presynaptic membrane assembly (GO:0097105)3.20696081
69viral protein processing (GO:0019082)3.19623891
70regulation of beta-amyloid formation (GO:1902003)3.17517554
71mRNA transcription from RNA polymerase II promoter (GO:0042789)3.15332850
72peptidyl-lysine methylation (GO:0018022)3.14341850
73trabecula morphogenesis (GO:0061383)3.11858001
74microtubule polymerization or depolymerization (GO:0031109)3.10198091
75negative regulation of cation channel activity (GO:2001258)3.09417461
76reactive oxygen species biosynthetic process (GO:1903409)3.09104970
77natural killer cell activation (GO:0030101)3.07303274
78negative regulation of receptor activity (GO:2000272)3.06985597
79regulation of histone phosphorylation (GO:0033127)3.05287066
80positive regulation of fatty acid beta-oxidation (GO:0032000)3.04182853
81negative regulation of protein tyrosine kinase activity (GO:0061099)3.02979680
82presynaptic membrane organization (GO:0097090)3.00546244
83dopamine biosynthetic process (GO:0042416)3.00498056
84protein-cofactor linkage (GO:0018065)2.99000562
85regulation of leukocyte mediated cytotoxicity (GO:0001910)2.97231180
86establishment of viral latency (GO:0019043)2.95632706
87cellular response to interleukin-15 (GO:0071350)2.95419193
88regulation of catecholamine metabolic process (GO:0042069)2.93105296
89regulation of dopamine metabolic process (GO:0042053)2.93105296
90regulation of interferon-beta biosynthetic process (GO:0045357)2.92188998
91intracellular protein transmembrane import (GO:0044743)2.90916404
92long-chain fatty acid biosynthetic process (GO:0042759)2.89261879
93cullin deneddylation (GO:0010388)2.88675876
94negative regulation of neurotransmitter transport (GO:0051589)2.87610358
95negative regulation of fatty acid biosynthetic process (GO:0045717)2.87484258
96ovulation cycle (GO:0042698)2.86003251
97megakaryocyte development (GO:0035855)2.83055389
98craniofacial suture morphogenesis (GO:0097094)2.82772508
99respiratory electron transport chain (GO:0022904)2.82473707
100protein localization to synapse (GO:0035418)2.82432609
101parturition (GO:0007567)2.82117965
102positive regulation of response to oxidative stress (GO:1902884)2.82000687
103positive regulation of cellular response to oxidative stress (GO:1900409)2.82000687
104microtubule depolymerization (GO:0007019)2.80845962
105negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.80672906
106negative regulation of calcium ion transmembrane transport (GO:1903170)2.80672906
107regulation of rhodopsin mediated signaling pathway (GO:0022400)2.78641682
108electron transport chain (GO:0022900)2.76683638
109positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.75897120
110positive regulation of protein import into nucleus, translocation (GO:0033160)2.75016897
111kinetochore organization (GO:0051383)2.74918188
112androgen biosynthetic process (GO:0006702)2.73376302
113positive regulation of epidermal cell differentiation (GO:0045606)2.72520288
114glycerophospholipid catabolic process (GO:0046475)2.72125523
115sodium ion export (GO:0071436)2.67940704
116regulation of isotype switching to IgG isotypes (GO:0048302)2.67916728
117potassium ion import (GO:0010107)2.67556235
118regulation of cell killing (GO:0031341)2.67059203
119rhodopsin mediated signaling pathway (GO:0016056)2.65482758
120protein deneddylation (GO:0000338)2.63965326
121gamma-aminobutyric acid signaling pathway (GO:0007214)2.63284712
122pyrimidine-containing compound transmembrane transport (GO:0072531)2.62761154
123transmission of nerve impulse (GO:0019226)2.61701580
124attachment of spindle microtubules to kinetochore (GO:0008608)2.57945394
125potassium ion homeostasis (GO:0055075)2.56941435
126GTP biosynthetic process (GO:0006183)2.56329702
127positive regulation of meiosis (GO:0045836)2.56074577
128protein targeting to Golgi (GO:0000042)2.55936755
129regulation of female receptivity (GO:0045924)2.55664929
130kinetochore assembly (GO:0051382)2.55007536
131positive regulation of fatty acid oxidation (GO:0046321)2.54804431
132apical protein localization (GO:0045176)2.51145050
1337-methylguanosine RNA capping (GO:0009452)2.50961145
134RNA capping (GO:0036260)2.50961145
135mitochondrial respiratory chain complex I assembly (GO:0032981)2.50937576
136NADH dehydrogenase complex assembly (GO:0010257)2.50937576
137mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50937576
138neuron recognition (GO:0008038)2.50867367
1397-methylguanosine mRNA capping (GO:0006370)2.50556065
140substantia nigra development (GO:0021762)2.46792508
141chromatin remodeling at centromere (GO:0031055)2.46642709
142positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.45966165
143positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.44728171
144synaptic transmission, dopaminergic (GO:0001963)2.44242103
145vocalization behavior (GO:0071625)2.44124082
146dopamine transport (GO:0015872)2.42315886
147histone exchange (GO:0043486)2.40608986
148regulation of glutamate secretion (GO:0014048)2.40079647
149synaptonemal complex organization (GO:0070193)2.40044062
150CENP-A containing nucleosome assembly (GO:0034080)2.38848528
151regulation of centriole replication (GO:0046599)2.37495959
152synaptic vesicle exocytosis (GO:0016079)2.36835380
153UTP biosynthetic process (GO:0006228)2.36717671
154protein localization to cilium (GO:0061512)2.36678036
155histone H2B ubiquitination (GO:0033523)2.35718003
156synaptonemal complex assembly (GO:0007130)2.34601898
157epithelial cilium movement (GO:0003351)2.33294907
158neuron-neuron synaptic transmission (GO:0007270)2.32953570
159establishment of mitochondrion localization (GO:0051654)2.32710883
160positive regulation of meiotic cell cycle (GO:0051446)2.32038445
161regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.31248875
162cilium movement (GO:0003341)2.29455768
163glutamate receptor signaling pathway (GO:0007215)2.28314679
164positive regulation of histone H3-K4 methylation (GO:0051571)2.27749992
165protein complex biogenesis (GO:0070271)2.26709494
166negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.26289822
167DNA damage response, detection of DNA damage (GO:0042769)2.26165906
168intraciliary transport (GO:0042073)2.24873885
169regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.24712314
170synaptic vesicle endocytosis (GO:0048488)2.24614335
171mitotic metaphase plate congression (GO:0007080)2.24416283
172protein polyglutamylation (GO:0018095)2.23203553
173transcription elongation from RNA polymerase I promoter (GO:0006362)2.23090556
174spliceosomal complex assembly (GO:0000245)2.22003852
175meiotic cell cycle (GO:0051321)2.21205359
176meiotic nuclear division (GO:0007126)2.20098884
177regulation of feeding behavior (GO:0060259)2.19468378
178regulation of protein kinase A signaling (GO:0010738)2.19085560
179centriole replication (GO:0007099)2.18502673
180neuronal action potential propagation (GO:0019227)2.17278352
181metaphase plate congression (GO:0051310)2.17030291
182axonemal dynein complex assembly (GO:0070286)2.16355746
183positive regulation of synapse assembly (GO:0051965)2.15234088
184regulation of gene expression by genetic imprinting (GO:0006349)2.14003558
185behavioral response to cocaine (GO:0048148)2.13924888
186DNA alkylation (GO:0006305)2.13613201
187DNA methylation (GO:0006306)2.13613201
188dendrite development (GO:0016358)2.12390447
189DNA replication-independent nucleosome assembly (GO:0006336)2.12341337
190DNA replication-independent nucleosome organization (GO:0034724)2.12341337
191negative regulation of meiosis (GO:0045835)2.12184008
192synaptic transmission, glutamatergic (GO:0035249)2.11371014
193neurofilament cytoskeleton organization (GO:0060052)15.5075007

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.79550504
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.71789894
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.14428879
4GBX2_23144817_ChIP-Seq_PC3_Human2.80306303
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.78682591
6FUS_26573619_Chip-Seq_HEK293_Human2.68758944
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.46296788
8TAF15_26573619_Chip-Seq_HEK293_Human2.42121465
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26738488
10VDR_22108803_ChIP-Seq_LS180_Human2.06235825
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.04214689
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03222686
13POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99827100
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94645088
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92328015
16SALL1_21062744_ChIP-ChIP_HESCs_Human1.92221396
17EWS_26573619_Chip-Seq_HEK293_Human1.90690930
18PIAS1_25552417_ChIP-Seq_VCAP_Human1.88801985
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88575753
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86973431
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86689487
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86366088
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86146023
24E2F7_22180533_ChIP-Seq_HELA_Human1.84929780
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.84794808
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80534720
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77300508
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.72929063
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71878092
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69961632
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68992665
32RNF2_27304074_Chip-Seq_NSC_Mouse1.66766990
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62077420
34AR_21572438_ChIP-Seq_LNCaP_Human1.62067338
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.60681117
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59502479
37CBP_20019798_ChIP-Seq_JUKART_Human1.59502479
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56736882
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.54451930
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53728597
41* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52851089
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.49009999
43P300_19829295_ChIP-Seq_ESCs_Human1.48981596
44* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48476249
45BCAT_22108803_ChIP-Seq_LS180_Human1.47487270
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.47084988
47MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.46412447
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.46347400
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.45995085
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.44541601
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44058629
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.43703684
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40563228
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40455942
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.40241239
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39473406
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39223747
58IGF1R_20145208_ChIP-Seq_DFB_Human1.38349236
59ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35974102
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34541472
61ER_23166858_ChIP-Seq_MCF-7_Human1.34151925
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33945571
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.33699301
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32942264
65JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32704645
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31897900
67REST_21632747_ChIP-Seq_MESCs_Mouse1.31870705
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31155727
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29719363
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29337096
71MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28888881
72RUNX_20019798_ChIP-Seq_JUKART_Human1.28792574
73TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28284386
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.27540198
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.27216758
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27192957
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26340627
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25660576
79SMAD4_21799915_ChIP-Seq_A2780_Human1.25389961
80TP53_22573176_ChIP-Seq_HFKS_Human1.25350879
81* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25333284
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24959107
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.24708941
84TP53_16413492_ChIP-PET_HCT116_Human1.23968890
85SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23317167
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.23177890
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23131113
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21164154
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21164154
90KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21164154
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20480634
92AR_25329375_ChIP-Seq_VCAP_Human1.20462546
93ZNF274_21170338_ChIP-Seq_K562_Hela1.19291259
94IRF1_19129219_ChIP-ChIP_H3396_Human1.19084847
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18183463
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16844118
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16664624
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16437207
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15127158
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14911169
101EED_16625203_ChIP-ChIP_MESCs_Mouse1.13840569
102KAP1_22055183_ChIP-Seq_ESCs_Mouse1.13116426
103ELK1_19687146_ChIP-ChIP_HELA_Human1.12468433
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12071030
105VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11275840
106GATA1_26923725_Chip-Seq_HPCs_Mouse1.11253107
107* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11041664
108KDM2B_26808549_Chip-Seq_REH_Human1.10617396
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.09705824
110SOX9_26525672_Chip-Seq_HEART_Mouse1.08682910
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08129453
112VDR_24787735_ChIP-Seq_THP-1_Human1.07814627
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.07184629
114JUN_21703547_ChIP-Seq_K562_Human1.06475551
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05712642
116RARB_27405468_Chip-Seq_BRAIN_Mouse1.04863198
117FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04455138
118MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04199512
119MYC_18940864_ChIP-ChIP_HL60_Human1.04190951
120SCL_19346495_ChIP-Seq_HPC-7_Human1.04002668
121SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03994307
122TTF2_22483619_ChIP-Seq_HELA_Human1.03815448
123GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.03697453
124STAT3_23295773_ChIP-Seq_U87_Human1.03589559
125SOX2_16153702_ChIP-ChIP_HESCs_Human1.02660547
126REST_19997604_ChIP-ChIP_NEURONS_Mouse1.02433659
127* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02273511
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02026724
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01824869
130SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01637298
131TCF4_23295773_ChIP-Seq_U87_Human1.01349628
132FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00961084
133MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99906424
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99888078
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99346669
136VDR_23849224_ChIP-Seq_CD4+_Human0.98890866
137PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98820681
138MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98316043
139SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97769468
140POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96444416
141E2F1_18555785_Chip-Seq_ESCs_Mouse0.96187030
142EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96158600
143RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96158600
144PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95486787
145TCF4_22108803_ChIP-Seq_LS180_Human0.93025075
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.92752845
147TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92741250
148* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92738180
149KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92705114
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91262659
151MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90052762
152REST_18959480_ChIP-ChIP_MESCs_Mouse0.89970727
153STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89547035
154CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88005268
155RING1B_27294783_Chip-Seq_ESCs_Mouse0.87202577
156SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85140396
157POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84300971
158TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84300971
159OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84256002
160EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82501319
161PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82210937
162PRDM14_20953172_ChIP-Seq_ESCs_Human0.81868925

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.18469743
2MP0008877_abnormal_DNA_methylation3.85197590
3MP0002876_abnormal_thyroid_physiology3.82989114
4MP0001529_abnormal_vocalization2.99907193
5MP0005671_abnormal_response_to2.98265515
6MP0003763_abnormal_thymus_physiology2.92215025
7MP0001986_abnormal_taste_sensitivity2.87574486
8MP0004270_analgesia2.47913253
9MP0003787_abnormal_imprinting2.39617801
10MP0001905_abnormal_dopamine_level2.38521017
11MP0004859_abnormal_synaptic_plasticity2.32426439
12MP0003635_abnormal_synaptic_transmissio2.14600064
13MP0006082_CNS_inflammation2.11774738
14MP0008057_abnormal_DNA_replication2.11272924
15MP0003121_genomic_imprinting2.00653228
16MP0009745_abnormal_behavioral_response1.97004274
17MP0000778_abnormal_nervous_system1.95137169
18MP0002272_abnormal_nervous_system1.94281324
19MP0001188_hyperpigmentation1.93555184
20MP0006292_abnormal_olfactory_placode1.91390684
21MP0003136_yellow_coat_color1.88611023
22MP0004264_abnormal_extraembryonic_tissu1.88391863
23MP0009046_muscle_twitch1.85120197
24MP0006276_abnormal_autonomic_nervous1.84342120
25MP0002064_seizures1.82212802
26MP0002734_abnormal_mechanical_nocicepti1.82032088
27MP0001440_abnormal_grooming_behavior1.81986602
28MP0002572_abnormal_emotion/affect_behav1.80115101
29MP0001968_abnormal_touch/_nociception1.76996235
30MP0006072_abnormal_retinal_apoptosis1.76763072
31MP0002063_abnormal_learning/memory/cond1.75038074
32MP0008875_abnormal_xenobiotic_pharmacok1.72738796
33MP0000569_abnormal_digit_pigmentation1.69019249
34MP0003122_maternal_imprinting1.68088357
35MP0001486_abnormal_startle_reflex1.66697009
36MP0005423_abnormal_somatic_nervous1.61811074
37MP0004957_abnormal_blastocyst_morpholog1.60255076
38MP0003718_maternal_effect1.59261265
39MP0010094_abnormal_chromosome_stability1.56024009
40MP0003123_paternal_imprinting1.54861103
41MP0002736_abnormal_nociception_after1.52383904
42MP0002735_abnormal_chemical_nociception1.46482121
43MP0004142_abnormal_muscle_tone1.43164965
44MP0003890_abnormal_embryonic-extraembry1.40914413
45MP0005386_behavior/neurological_phenoty1.40678207
46MP0004924_abnormal_behavior1.40678207
47MP0002184_abnormal_innervation1.40664462
48MP0008932_abnormal_embryonic_tissue1.40395462
49MP0008058_abnormal_DNA_repair1.39026661
50MP0002067_abnormal_sensory_capabilities1.37592807
51MP0005410_abnormal_fertilization1.36801878
52MP0001485_abnormal_pinna_reflex1.34945444
53MP0001929_abnormal_gametogenesis1.32300259
54MP0002210_abnormal_sex_determination1.29138629
55MP0003195_calcinosis1.28883065
56MP0002102_abnormal_ear_morphology1.28583122
57MP0002653_abnormal_ependyma_morphology1.28511478
58MP0003950_abnormal_plasma_membrane1.28409518
59MP0004742_abnormal_vestibular_system1.27232666
60MP0003698_abnormal_male_reproductive1.27021096
61MP0002723_abnormal_immune_serum1.24625250
62MP0001970_abnormal_pain_threshold1.24601628
63MP0005409_darkened_coat_color1.24550711
64MP0001800_abnormal_humoral_immune1.23925101
65MP0003937_abnormal_limbs/digits/tail_de1.22466240
66MP0002420_abnormal_adaptive_immunity1.22341342
67MP0003866_abnormal_defecation1.21541886
68MP0009333_abnormal_splenocyte_physiolog1.21426278
69MP0002733_abnormal_thermal_nociception1.19800251
70MP0005387_immune_system_phenotype1.19488727
71MP0001790_abnormal_immune_system1.19488727
72MP0004145_abnormal_muscle_electrophysio1.18785439
73MP0004133_heterotaxia1.18140009
74MP0002557_abnormal_social/conspecific_i1.16896698
75MP0001819_abnormal_immune_cell1.16507872
76MP0005025_abnormal_response_to1.16078079
77MP0002882_abnormal_neuron_morphology1.14191047
78MP0005623_abnormal_meninges_morphology1.12839158
79MP0003693_abnormal_embryo_hatching1.11934889
80MP0000631_abnormal_neuroendocrine_gland1.11202310
81MP0002398_abnormal_bone_marrow1.11074876
82MP0000955_abnormal_spinal_cord1.10724499
83MP0005171_absent_coat_pigmentation1.10382061
84MP0003111_abnormal_nucleus_morphology1.10126592
85MP0001501_abnormal_sleep_pattern1.10036960
86MP0003861_abnormal_nervous_system1.09299724
87MP0002132_abnormal_respiratory_system1.09041095
88MP0009379_abnormal_foot_pigmentation1.07925045
89MP0002638_abnormal_pupillary_reflex1.07359622
90MP0002152_abnormal_brain_morphology1.06852686
91MP0009785_altered_susceptibility_to1.06687389
92MP0003077_abnormal_cell_cycle1.06685107
93MP0005551_abnormal_eye_electrophysiolog1.05430444
94MP0002752_abnormal_somatic_nervous1.05289391
95MP0005000_abnormal_immune_tolerance1.05098097
96MP0001145_abnormal_male_reproductive1.04493991
97MP0002127_abnormal_cardiovascular_syste1.03194960
98MP0000653_abnormal_sex_gland1.03156634
99MP0000716_abnormal_immune_system1.00960621
100MP0005499_abnormal_olfactory_system1.00916294
101MP0005394_taste/olfaction_phenotype1.00916294
102MP0001984_abnormal_olfaction0.98648387
103MP0003646_muscle_fatigue0.98536361
104MP0002163_abnormal_gland_morphology0.97864327
105MP0002837_dystrophic_cardiac_calcinosis0.97461638
106MP0003938_abnormal_ear_development0.96741368
107MP0002066_abnormal_motor_capabilities/c0.96616271
108MP0001963_abnormal_hearing_physiology0.96154803
109MP0001119_abnormal_female_reproductive0.95081427
110MP0000920_abnormal_myelination0.94957159
111MP0003315_abnormal_perineum_morphology0.93038431
112MP0002751_abnormal_autonomic_nervous0.92017559
113MP0003786_premature_aging0.89997560
114MP0003632_abnormal_nervous_system0.89848874
115MP0002229_neurodegeneration0.89243230
116MP0008789_abnormal_olfactory_epithelium0.87081088
117MP0008995_early_reproductive_senescence0.86672264
118MP0005253_abnormal_eye_physiology0.84632857
119MP0004019_abnormal_vitamin_homeostasis0.84624912
120MP0005379_endocrine/exocrine_gland_phen0.84300347
121MP0005645_abnormal_hypothalamus_physiol0.83134267
122MP0002161_abnormal_fertility/fecundity0.82934161
123MP0001727_abnormal_embryo_implantation0.81368483
124MP0000566_synostosis0.81242147
125MP0010386_abnormal_urinary_bladder0.81137265
126MP0002160_abnormal_reproductive_system0.80512535
127MP0004885_abnormal_endolymph0.80155984
128MP0002822_catalepsy0.80149377
129MP0000026_abnormal_inner_ear0.79625690
130MP0005646_abnormal_pituitary_gland0.79404823
131MP0004811_abnormal_neuron_physiology0.79024314
132MP0003119_abnormal_digestive_system0.78863568
133MP0001666_abnormal_nutrient_absorption0.77589579
134MP0003699_abnormal_female_reproductive0.77217677
135MP0002429_abnormal_blood_cell0.76238449
136MP0005084_abnormal_gallbladder_morpholo0.73047559
137MP0003936_abnormal_reproductive_system0.72815644
138MP0001835_abnormal_antigen_presentation0.72650515
139MP0005085_abnormal_gallbladder_physiolo0.70862664
140MP0008872_abnormal_physiological_respon0.69518473
141MP0001765_abnormal_ion_homeostasis0.69168650
142MP0002452_abnormal_antigen_presenting0.65763097
143MP0001944_abnormal_pancreas_morphology0.64664062
144MP0005174_abnormal_tail_pigmentation0.64581834
145MP0002148_abnormal_hypersensitivity_rea0.63827419
146MP0003879_abnormal_hair_cell0.62143562
147MP0008775_abnormal_heart_ventricle0.57062863
148MP0003724_increased_susceptibility_to0.56974834
149MP0002693_abnormal_pancreas_physiology0.56175957
150MP0003631_nervous_system_phenotype0.54667284
151MP0002277_abnormal_respiratory_mucosa0.54479358
152MP0010329_abnormal_lipoprotein_level0.54327660

Predicted human phenotypes

RankGene SetZ-score
1Duplicated collecting system (HP:0000081)9.58305991
2Abnormality of the renal collecting system (HP:0004742)8.61920479
3Reticulocytopenia (HP:0001896)8.12860411
4Abnormality of pyrimidine metabolism (HP:0004353)7.40153319
5Abnormality of DNA repair (HP:0003254)6.75355497
6Oral leukoplakia (HP:0002745)5.80441829
7Aplastic anemia (HP:0001915)5.78146754
8Ureteral duplication (HP:0000073)5.50391556
9Duplication of thumb phalanx (HP:0009942)4.94505678
10Ectopic kidney (HP:0000086)4.88987002
11Absent thumb (HP:0009777)4.33787325
12Autoimmune thrombocytopenia (HP:0001973)4.23810894
13Enlarged epiphyses (HP:0010580)3.98914873
14Stomach cancer (HP:0012126)3.97768810
15Eosinophilia (HP:0001880)3.88363719
16Thyroid-stimulating hormone excess (HP:0002925)3.77829897
17Abnormality of T cell number (HP:0011839)3.77407625
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.66287609
19Acute necrotizing encephalopathy (HP:0006965)3.63347441
20Abnormality of B cell number (HP:0010975)3.57073767
21Renal cortical cysts (HP:0000803)3.54377220
22Autoimmune hemolytic anemia (HP:0001890)3.44678449
23Abnormality of the labia minora (HP:0012880)3.32134116
24Meckel diverticulum (HP:0002245)3.27334599
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.20114609
26Degeneration of the lateral corticospinal tracts (HP:0002314)3.20114609
27Pancytopenia (HP:0001876)3.18321326
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.18289232
29Abnormality of the preputium (HP:0100587)3.17267311
30Abnormality of the ileum (HP:0001549)3.15080862
31Abnormality of eosinophils (HP:0001879)3.09458731
32Progressive macrocephaly (HP:0004481)3.08263919
33Focal motor seizures (HP:0011153)3.05466083
34Granulocytopenia (HP:0001913)3.05098026
35Abnormal delayed hypersensitivity skin test (HP:0002963)3.04901229
36Abnormal mitochondria in muscle tissue (HP:0008316)3.03158268
37Increased IgM level (HP:0003496)2.95569319
38Clubbing of toes (HP:0100760)2.95232677
39Increased hepatocellular lipid droplets (HP:0006565)2.94356236
40Abnormal ciliary motility (HP:0012262)2.89754605
41Mitochondrial inheritance (HP:0001427)2.87552718
42Hypergonadotropic hypogonadism (HP:0000815)2.86874549
43Abnormality of T cells (HP:0002843)2.84931634
44Abnormal respiratory motile cilium physiology (HP:0012261)2.78314788
45Joint swelling (HP:0001386)2.73847945
46Abnormality of chromosome stability (HP:0003220)2.72848482
47Dynein arm defect of respiratory motile cilia (HP:0012255)2.72227683
48Absent/shortened dynein arms (HP:0200106)2.72227683
49Atonic seizures (HP:0010819)2.68318724
50Supernumerary spleens (HP:0009799)2.68308468
51Acute encephalopathy (HP:0006846)2.58110319
52Increased serum pyruvate (HP:0003542)2.56762099
53Abnormality of glycolysis (HP:0004366)2.56762099
54Abnormality of the corticospinal tract (HP:0002492)2.50733945
55Genital tract atresia (HP:0001827)2.50502351
56Gait imbalance (HP:0002141)2.49247331
57Vaginal atresia (HP:0000148)2.43640681
58Neutropenia (HP:0001875)2.42325576
59Medial flaring of the eyebrow (HP:0010747)2.41920255
60Abnormal respiratory motile cilium morphology (HP:0005938)2.40271647
61Abnormal respiratory epithelium morphology (HP:0012253)2.40271647
62Sensory axonal neuropathy (HP:0003390)2.39712310
63Abnormality of the carotid arteries (HP:0005344)2.38445534
64T lymphocytopenia (HP:0005403)2.36941956
65Cerebral hypomyelination (HP:0006808)2.34621326
66Increased CSF lactate (HP:0002490)2.34288448
67Leukopenia (HP:0001882)2.33694390
68Congenital primary aphakia (HP:0007707)2.33572254
69Abnormality of the renal cortex (HP:0011035)2.33275485
70Abnormality of the phalanges of the 2nd finger (HP:0009541)2.30519255
71Hypochromic anemia (HP:0001931)2.29768169
72Abnormal hair whorl (HP:0010721)2.29278506
73Abnormality of nucleobase metabolism (HP:0010932)2.27746839
74Flattened epiphyses (HP:0003071)2.27588166
75Leukodystrophy (HP:0002415)2.27358714
76Hypoplasia of the capital femoral epiphysis (HP:0003090)2.26861182
77Lipid accumulation in hepatocytes (HP:0006561)2.26642777
78Epileptic encephalopathy (HP:0200134)2.23694601
79Limb dystonia (HP:0002451)2.21132663
80Abnormality of the vertebral endplates (HP:0005106)2.19535880
81Renal Fanconi syndrome (HP:0001994)2.18895774
82Birth length less than 3rd percentile (HP:0003561)2.17957869
83Abnormality of the epiphysis of the femoral head (HP:0010574)2.15746286
84Myokymia (HP:0002411)2.14307661
85Optic disc pallor (HP:0000543)2.13249791
86Focal seizures (HP:0007359)2.12541366
87Rough bone trabeculation (HP:0100670)2.11519320
88Absent radius (HP:0003974)2.08988788
89Mutism (HP:0002300)2.08377960
90Absent forearm bone (HP:0003953)2.06307020
91Aplasia involving forearm bones (HP:0009822)2.06307020
92Abnormality of the femoral head (HP:0003368)2.04864887
93Nephrogenic diabetes insipidus (HP:0009806)2.04140981
94Bone marrow hypocellularity (HP:0005528)2.04077014
95Cellular immunodeficiency (HP:0005374)2.03589616
96Abnormality of reticulocytes (HP:0004312)2.03196105
97Rhinitis (HP:0012384)2.02247601
98Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.00601488
99Leukocytosis (HP:0001974)1.99010705
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98239719
101Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.96083297
102Abnormality of femoral epiphyses (HP:0006499)1.96083297
103Retinal dysplasia (HP:0007973)1.95879335
104Aplasia/Hypoplasia of the tibia (HP:0005772)1.95211616
105Broad-based gait (HP:0002136)1.94401288
106Abnormality of midbrain morphology (HP:0002418)1.92246238
107Molar tooth sign on MRI (HP:0002419)1.92246238
108Small intestinal stenosis (HP:0012848)1.89154193
109Duodenal stenosis (HP:0100867)1.89154193
110Short thumb (HP:0009778)1.88207135
111Insidious onset (HP:0003587)1.87871435
112Termporal pattern (HP:0011008)1.87871435
113Oligodactyly (hands) (HP:0001180)1.87765190
114Horseshoe kidney (HP:0000085)1.87660490
115Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87635980
116Absence seizures (HP:0002121)1.87253833
117Facial hemangioma (HP:0000329)1.86713905
118Progressive cerebellar ataxia (HP:0002073)1.86545157
119Poor coordination (HP:0002370)1.86417021
120Short tibia (HP:0005736)1.86016534
121Megalocornea (HP:0000485)1.85916806
122Tetraplegia (HP:0002445)1.85392225
123Nephronophthisis (HP:0000090)1.83516702
124Abnormality of the septum pellucidum (HP:0007375)1.82377708
125Hepatocellular necrosis (HP:0001404)1.81689658
126Absent epiphyses (HP:0010577)1.80615300
127Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80615300
128Hemiplegia (HP:0002301)1.80528471
129Absent septum pellucidum (HP:0001331)1.80489818
130Delusions (HP:0000746)1.80357916
131Abnormality of cells of the lymphoid lineage (HP:0012140)1.79818061
132Chromsome breakage (HP:0040012)1.79602861
133Cerebral inclusion bodies (HP:0100314)1.79214765
134Increased intramyocellular lipid droplets (HP:0012240)1.79016455
135Septo-optic dysplasia (HP:0100842)1.78644693
136Gastroesophageal reflux (HP:0002020)1.77281340
137Gaze-evoked nystagmus (HP:0000640)1.76773992
138Dialeptic seizures (HP:0011146)1.74046960
139Hypoplastic pelvis (HP:0008839)1.73683574
140Renal agenesis (HP:0000104)1.71009333
141Pancreatic fibrosis (HP:0100732)1.70173909
142Adrenal hypoplasia (HP:0000835)1.68770519
143Parakeratosis (HP:0001036)1.67879583
144Febrile seizures (HP:0002373)1.66969208
145Exercise intolerance (HP:0003546)1.66676166
146Retrobulbar optic neuritis (HP:0100654)1.66194457
147Optic neuritis (HP:0100653)1.66194457
148Tracheoesophageal fistula (HP:0002575)1.66056623
149Congenital sensorineural hearing impairment (HP:0008527)1.65469510
150Bifid tongue (HP:0010297)1.64545235
151Partial duplication of the phalanx of hand (HP:0009999)1.63358821
152Cupped ear (HP:0000378)1.61863325
153Preaxial hand polydactyly (HP:0001177)1.61624919
154Patellar aplasia (HP:0006443)1.60764201
155Vasculitis (HP:0002633)1.60665014
156Amblyopia (HP:0000646)1.58780824
157Nephroblastoma (Wilms tumor) (HP:0002667)1.58266603
158Stenosis of the external auditory canal (HP:0000402)1.57923635
159Premature graying of hair (HP:0002216)1.57805136
160Volvulus (HP:0002580)1.57533882
161Dysmetria (HP:0001310)1.57204508
162Peripheral hypomyelination (HP:0007182)1.57176960
163Confusion (HP:0001289)1.57147178
164Progressive external ophthalmoplegia (HP:0000590)1.56785400
165Astigmatism (HP:0000483)1.56755579
166Specific learning disability (HP:0001328)1.56707929
167Pallor (HP:0000980)1.56577764
168Triphalangeal thumb (HP:0001199)1.56436027
169Absent speech (HP:0001344)1.55985657
170Breast hypoplasia (HP:0003187)1.55630486
171Embryonal renal neoplasm (HP:0011794)1.55349474
172CNS hypomyelination (HP:0003429)1.55302139
173Disproportionate short-trunk short stature (HP:0003521)1.55204635
174Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.54678352
175Abnormality of the duodenum (HP:0002246)1.54308730
176Neurofibrillary tangles (HP:0002185)1.54228406
177Autoamputation (HP:0001218)1.54218388
178Abnormality of T cell physiology (HP:0011840)1.54022450
179Chromosomal breakage induced by crosslinking agents (HP:0003221)1.53231096
180Fetal akinesia sequence (HP:0001989)1.52481129
181Exertional dyspnea (HP:0002875)1.52369035
182Abnormal trabecular bone morphology (HP:0100671)1.49873160
183Syringomyelia (HP:0003396)1.49420017
184Spinal cord lesions (HP:0100561)1.49420017
185Epiphyseal dysplasia (HP:0002656)1.49339612
186Progressive neurologic deterioration (HP:0002344)1.48460585

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.00752095
2MAP4K16.87437306
3PNCK5.10499623
4BCKDK3.07431656
5CASK2.52041097
6CDC72.50263002
7STK392.48849911
8MAP3K42.33776250
9EPHA42.12192848
10PLK22.10818216
11TAOK312.1788481
12NTRK31.99836789
13MAP2K71.88700864
14WEE11.86789929
15BCR1.80633995
16NME11.75530243
17OXSR11.75476361
18ZAP701.65284015
19BMPR21.59244211
20SRPK11.58097040
21TNIK1.57926143
22BUB11.52779863
23PLK41.52778213
24TTK1.52738952
25MKNK11.46105734
26CSNK1G31.37414135
27MKNK21.36266569
28PLK31.34027197
29PBK1.29444589
30MARK11.29279722
31GRK51.27309000
32TSSK61.23940009
33MAPK131.23742342
34FGR1.22700253
35MAP3K91.21350407
36MAP3K121.18374197
37BMPR1B1.18257750
38LATS21.18096004
39WNK41.16844310
40MINK11.14563322
41FRK1.13729156
42CSNK1G21.13104635
43MAP3K61.12465343
44CSNK1G11.11455782
45UHMK11.06364732
46IKBKE1.04016876
47CSNK1A1L1.01752022
48STK161.01156064
49BRAF1.00716649
50CDK190.99649493
51ARAF0.97728770
52NLK0.96954169
53BRD40.95347137
54CHEK20.94071895
55CDK120.93228332
56SGK10.91102972
57PLK10.90171898
58MAPKAPK50.89919899
59CAMK2A0.88558482
60SYK0.88207811
61CAMK1D0.87052786
62PTK2B0.84639546
63GRK70.84361424
64DYRK20.83950411
65TESK20.82996997
66STK38L0.82689239
67CAMK2B0.81972137
68WNK30.81015433
69NEK60.80887588
70VRK10.80375852
71CSNK1E0.79590709
72LIMK10.79417697
73CDK140.78905329
74JAK10.78756834
75CAMKK20.76944732
76MAP2K40.76745782
77CDK30.75643752
78WNK10.74786068
79ITK0.73513613
80PIK3CA0.72824407
81ROCK20.70834585
82CDK180.69362113
83ERBB40.68499673
84NTRK20.67758547
85CDK150.66889899
86DYRK1A0.66465323
87CDK80.66434756
88AURKA0.65916223
89CHEK10.65749626
90PRPF4B0.65348819
91CDK11A0.62617238
92TYRO30.62586392
93LCK0.60986560
94MST40.60465574
95MELK0.59151176
96TBK10.56863357
97CDK50.56263558
98ATM0.54797806
99MUSK0.54740044
100PRKCG0.54608075
101PINK10.54427939
102CDK10.54138045
103CSNK2A20.54078699
104PRKCQ0.53570600
105LYN0.53148219
106EIF2AK10.51992888
107MOS0.51940981
108CAMK1G0.51599210
109MAPK120.51557995
110PKN10.50858190
111SGK20.50376167
112CAMK2D0.50201474
113CAMKK10.50122513
114INSRR0.49986237
115AKT30.49868140
116CSNK1D0.47313906
117SIK20.47280810
118CAMK10.46851504
119RIPK40.46581989
120NTRK10.46052654
121ADRBK20.45805453
122PAK30.45740193
123HCK0.45092261
124EIF2AK30.44877480
125GRK10.44310391
126KSR10.43923048
127PDK40.42931077
128PDK30.42931077
129CDK20.42923248
130PAK60.42506604
131ACVR1B0.42152804
132IKBKB0.38603728
133SGK2230.38459574
134SGK4940.38459574
135MAP4K20.37010553
136FES0.33995952
137TEC0.31668002
138PRKAA20.30339577
139DAPK20.29797492
140TNK20.28834925
141CSNK1A10.28489211
142IGF1R0.28061187
143PRKAA10.27939272
144PHKG20.27605490
145PHKG10.27605490
146KIT0.27458394
147ADRBK10.26419000
148BTK0.26005947
149MAP2K60.25779581
150ATR0.24522428
151FYN0.22863364
152ERBB20.20858864
153PIM10.19370531
154PRKCA0.19058863
155MAPK150.18715796
156TESK10.18242378
157MAPK30.18043079
158PRKCE0.17720228
159RPS6KA30.16725335
160PRKCH0.16111285
161JAK30.15894752
162PRKACA0.15398779
163TRPM70.15370810
164AKT10.15125094
165TIE10.12415699
166PRKCZ0.12058875
167PRKCB0.11936456
168TLK10.11927861
169INSR0.11409753
170MAPK140.11335907
171SGK30.10727070
172RPS6KA50.10602501

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.56047493
2Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.43097928
3Parkinsons disease_Homo sapiens_hsa050122.90595328
4Nicotine addiction_Homo sapiens_hsa050332.83588946
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.71996592
6Graft-versus-host disease_Homo sapiens_hsa053322.67595861
7Allograft rejection_Homo sapiens_hsa053302.64252157
8Huntingtons disease_Homo sapiens_hsa050162.60052652
9Autoimmune thyroid disease_Homo sapiens_hsa053202.58881260
10RNA polymerase_Homo sapiens_hsa030202.53285238
11Type I diabetes mellitus_Homo sapiens_hsa049402.45605655
12Alzheimers disease_Homo sapiens_hsa050102.44991158
13Proteasome_Homo sapiens_hsa030502.42978635
14Basal transcription factors_Homo sapiens_hsa030222.36293355
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.18102402
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10868080
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.09785828
18Asthma_Homo sapiens_hsa053102.01793995
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.93774265
20Mismatch repair_Homo sapiens_hsa034301.85685531
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.81844188
22Spliceosome_Homo sapiens_hsa030401.81606015
23Collecting duct acid secretion_Homo sapiens_hsa049661.81596617
24Homologous recombination_Homo sapiens_hsa034401.80787288
25RNA transport_Homo sapiens_hsa030131.74561611
26Protein export_Homo sapiens_hsa030601.68540942
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67309025
28Cardiac muscle contraction_Homo sapiens_hsa042601.66772388
29Oocyte meiosis_Homo sapiens_hsa041141.65280492
30Long-term potentiation_Homo sapiens_hsa047201.64574535
31Amphetamine addiction_Homo sapiens_hsa050311.64474357
32Serotonergic synapse_Homo sapiens_hsa047261.64277559
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62241542
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61802128
35Non-homologous end-joining_Homo sapiens_hsa034501.59864321
36Synaptic vesicle cycle_Homo sapiens_hsa047211.59862270
37Primary immunodeficiency_Homo sapiens_hsa053401.58323947
38Ribosome_Homo sapiens_hsa030101.57564311
39Nucleotide excision repair_Homo sapiens_hsa034201.55841116
40RNA degradation_Homo sapiens_hsa030181.54031249
41Glutamatergic synapse_Homo sapiens_hsa047241.53675921
42Phototransduction_Homo sapiens_hsa047441.51232223
43Fanconi anemia pathway_Homo sapiens_hsa034601.45596051
44Dopaminergic synapse_Homo sapiens_hsa047281.45492222
45mRNA surveillance pathway_Homo sapiens_hsa030151.42971981
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41022218
47T cell receptor signaling pathway_Homo sapiens_hsa046601.40213783
48Staphylococcus aureus infection_Homo sapiens_hsa051501.40141091
49Long-term depression_Homo sapiens_hsa047301.39132492
50GABAergic synapse_Homo sapiens_hsa047271.38591143
51Pancreatic secretion_Homo sapiens_hsa049721.37501596
52Cell cycle_Homo sapiens_hsa041101.35623669
53Morphine addiction_Homo sapiens_hsa050321.35327548
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32337114
55Taste transduction_Homo sapiens_hsa047421.31817782
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31687192
57Circadian entrainment_Homo sapiens_hsa047131.24713223
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.22215187
59Vibrio cholerae infection_Homo sapiens_hsa051101.21476985
60Ether lipid metabolism_Homo sapiens_hsa005651.20183294
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19335738
62SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19147110
63Pyruvate metabolism_Homo sapiens_hsa006201.18249364
64Hematopoietic cell lineage_Homo sapiens_hsa046401.17919962
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17120860
66DNA replication_Homo sapiens_hsa030301.17004371
67Axon guidance_Homo sapiens_hsa043601.12654008
68Cocaine addiction_Homo sapiens_hsa050301.05260193
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99153791
70Pyrimidine metabolism_Homo sapiens_hsa002400.98948807
71Butanoate metabolism_Homo sapiens_hsa006500.95518094
72Propanoate metabolism_Homo sapiens_hsa006400.95131532
73Olfactory transduction_Homo sapiens_hsa047400.94500561
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91429635
75Cholinergic synapse_Homo sapiens_hsa047250.91032855
76Renin secretion_Homo sapiens_hsa049240.90476126
77Bile secretion_Homo sapiens_hsa049760.89436274
78Purine metabolism_Homo sapiens_hsa002300.88942080
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88240465
80Salivary secretion_Homo sapiens_hsa049700.86760896
81Leishmaniasis_Homo sapiens_hsa051400.85297640
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84257285
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83340765
84Antigen processing and presentation_Homo sapiens_hsa046120.82503457
85Calcium signaling pathway_Homo sapiens_hsa040200.81241971
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80509358
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79205512
88Malaria_Homo sapiens_hsa051440.77502958
89Dorso-ventral axis formation_Homo sapiens_hsa043200.77228160
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76999687
91Steroid biosynthesis_Homo sapiens_hsa001000.76845990
92Oxytocin signaling pathway_Homo sapiens_hsa049210.76525053
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75611214
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74971524
95Wnt signaling pathway_Homo sapiens_hsa043100.73696430
96Hedgehog signaling pathway_Homo sapiens_hsa043400.72174566
97Gap junction_Homo sapiens_hsa045400.71889819
98Viral myocarditis_Homo sapiens_hsa054160.71712432
99Nitrogen metabolism_Homo sapiens_hsa009100.70713090
100Platelet activation_Homo sapiens_hsa046110.69344139
101Alcoholism_Homo sapiens_hsa050340.68847816
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.67357051
103Vitamin digestion and absorption_Homo sapiens_hsa049770.66607260
104Caffeine metabolism_Homo sapiens_hsa002320.66127230
105Insulin secretion_Homo sapiens_hsa049110.62148211
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61078826
107Base excision repair_Homo sapiens_hsa034100.60660801
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60257205
109GnRH signaling pathway_Homo sapiens_hsa049120.60209324
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60144687
111Melanogenesis_Homo sapiens_hsa049160.59343820
112Protein digestion and absorption_Homo sapiens_hsa049740.59330637
113Gastric acid secretion_Homo sapiens_hsa049710.59015070
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.56626481
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56286663
116Arachidonic acid metabolism_Homo sapiens_hsa005900.54673674
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53982132
118Osteoclast differentiation_Homo sapiens_hsa043800.53980945
119Mineral absorption_Homo sapiens_hsa049780.52424714
120B cell receptor signaling pathway_Homo sapiens_hsa046620.50401226
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49900346
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47837083
123Fatty acid biosynthesis_Homo sapiens_hsa000610.47336971
124Galactose metabolism_Homo sapiens_hsa000520.46613113
125Tight junction_Homo sapiens_hsa045300.45427307
126Estrogen signaling pathway_Homo sapiens_hsa049150.45124873
127Epstein-Barr virus infection_Homo sapiens_hsa051690.44629878
128Ras signaling pathway_Homo sapiens_hsa040140.44227342
129Fatty acid elongation_Homo sapiens_hsa000620.43986272
130ErbB signaling pathway_Homo sapiens_hsa040120.42796251
131Linoleic acid metabolism_Homo sapiens_hsa005910.42718412
132Renal cell carcinoma_Homo sapiens_hsa052110.42594838
133TGF-beta signaling pathway_Homo sapiens_hsa043500.41929469
134Thyroid hormone synthesis_Homo sapiens_hsa049180.41902949
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41466864
136cAMP signaling pathway_Homo sapiens_hsa040240.40793405
137Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40778460
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.40084323
139Sphingolipid metabolism_Homo sapiens_hsa006000.37915816
140cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37722592
141Hippo signaling pathway_Homo sapiens_hsa043900.35073313
142MAPK signaling pathway_Homo sapiens_hsa040100.34691794
143Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34523024
144Rheumatoid arthritis_Homo sapiens_hsa053230.33506965
145Ovarian steroidogenesis_Homo sapiens_hsa049130.31255152
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29010252
147Choline metabolism in cancer_Homo sapiens_hsa052310.26023168
148Basal cell carcinoma_Homo sapiens_hsa052170.24978309
149Circadian rhythm_Homo sapiens_hsa047100.24545836
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.21014476
151Vitamin B6 metabolism_Homo sapiens_hsa007500.20541059
152Metabolic pathways_Homo sapiens_hsa011000.20532238

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