MPHOSPH9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1centriole replication (GO:0007099)4.39003102
2replication fork processing (GO:0031297)4.37643468
3DNA double-strand break processing (GO:0000729)4.18717799
4double-strand break repair via nonhomologous end joining (GO:0006303)4.14004007
5non-recombinational repair (GO:0000726)4.14004007
6mitotic sister chromatid cohesion (GO:0007064)4.13280958
7histone H3-K9 methylation (GO:0051567)3.98088533
8microtubule depolymerization (GO:0007019)3.81830963
9DNA ligation (GO:0006266)3.78036004
10resolution of meiotic recombination intermediates (GO:0000712)3.77688095
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.72681212
12DNA topological change (GO:0006265)3.68767383
13synapsis (GO:0007129)3.64096261
14recombinational repair (GO:0000725)3.64022443
15double-strand break repair via homologous recombination (GO:0000724)3.62893290
16mitotic chromosome condensation (GO:0007076)3.59229234
17DNA replication checkpoint (GO:0000076)3.59219975
18nuclear pore complex assembly (GO:0051292)3.56724654
19nucleotide-excision repair, DNA gap filling (GO:0006297)3.54477332
20DNA strand elongation involved in DNA replication (GO:0006271)3.46821598
21sister chromatid segregation (GO:0000819)3.46479187
22mitotic sister chromatid segregation (GO:0000070)3.45704347
23telomere maintenance via semi-conservative replication (GO:0032201)3.43908091
24kinetochore organization (GO:0051383)3.40401609
25somatic diversification of immune receptors via somatic mutation (GO:0002566)3.39452871
26somatic hypermutation of immunoglobulin genes (GO:0016446)3.39452871
27telomere maintenance via recombination (GO:0000722)3.38939220
28negative regulation of DNA recombination (GO:0045910)3.36223589
29centriole assembly (GO:0098534)3.32523931
30regulation of centriole replication (GO:0046599)3.30233500
31V(D)J recombination (GO:0033151)3.29976985
32DNA strand elongation (GO:0022616)3.28297510
33nuclear pore organization (GO:0006999)3.26870436
34DNA replication-dependent nucleosome assembly (GO:0006335)3.26345372
35DNA replication-dependent nucleosome organization (GO:0034723)3.26345372
36centrosome organization (GO:0051297)3.24530003
37mitotic spindle checkpoint (GO:0071174)3.23815962
38histone H3-K4 trimethylation (GO:0080182)3.23173127
39protein K6-linked ubiquitination (GO:0085020)3.20909425
40mitotic metaphase plate congression (GO:0007080)3.20842302
41regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.20726557
42mitotic G2/M transition checkpoint (GO:0044818)3.20656137
43histone H3-K9 modification (GO:0061647)3.16102166
44response to pheromone (GO:0019236)3.14950299
45protein localization to kinetochore (GO:0034501)3.14012184
46negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11866484
47microtubule organizing center organization (GO:0031023)3.11439652
48metaphase plate congression (GO:0051310)3.11421657
49microtubule anchoring (GO:0034453)3.10668861
50double-strand break repair (GO:0006302)3.09940725
51monoubiquitinated protein deubiquitination (GO:0035520)3.09756938
52peptidyl-lysine trimethylation (GO:0018023)3.08516933
53mRNA splice site selection (GO:0006376)3.08267046
54postreplication repair (GO:0006301)3.08156044
55mitotic spindle assembly checkpoint (GO:0007094)3.08030431
56somatic cell DNA recombination (GO:0016444)3.07530020
57somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.07530020
58regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.07191658
59regulation of mitotic spindle checkpoint (GO:1903504)3.07191658
60reciprocal DNA recombination (GO:0035825)3.06986259
61reciprocal meiotic recombination (GO:0007131)3.06986259
62RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.06813070
63pre-miRNA processing (GO:0031054)3.05084613
64peptidyl-lysine dimethylation (GO:0018027)3.04103818
65meiotic chromosome segregation (GO:0045132)2.99223291
66DNA synthesis involved in DNA repair (GO:0000731)2.98598552
67protein localization to chromosome, centromeric region (GO:0071459)2.97566458
68positive regulation of chromosome segregation (GO:0051984)2.97097969
69kinetochore assembly (GO:0051382)2.96747057
70somatic diversification of immune receptors (GO:0002200)2.95780226
71regulation of telomere maintenance (GO:0032204)2.93490921
72positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.93452100
73microtubule polymerization or depolymerization (GO:0031109)2.92267250
74DNA replication-independent nucleosome assembly (GO:0006336)2.91980472
75DNA replication-independent nucleosome organization (GO:0034724)2.91980472
76chromatin remodeling at centromere (GO:0031055)2.90666679
77histone H2A acetylation (GO:0043968)2.89862101
78CENP-A containing nucleosome assembly (GO:0034080)2.88576471
79histone exchange (GO:0043486)2.87752009
80piRNA metabolic process (GO:0034587)2.87236906
81regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85302765
82sister chromatid cohesion (GO:0007062)2.84667339
83peptidyl-lysine methylation (GO:0018022)2.82789470
84cilium or flagellum-dependent cell motility (GO:0001539)2.78073980
85histone lysine methylation (GO:0034968)2.77820288
86establishment of chromosome localization (GO:0051303)2.77584260
87negative regulation of histone methylation (GO:0031061)2.77281572
88regulation of DNA endoreduplication (GO:0032875)2.74977706
89epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.74756133
90substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.73790190
91substrate-independent telencephalic tangential migration (GO:0021826)2.73790190
92replicative senescence (GO:0090399)2.69934445
93protein localization to chromosome (GO:0034502)2.69495761
94regulation of DNA damage checkpoint (GO:2000001)2.67885089
95regulation of histone H3-K9 methylation (GO:0051570)2.65628027
96histone H3-K4 methylation (GO:0051568)2.59722896
97male meiosis (GO:0007140)2.59185308
98pore complex assembly (GO:0046931)2.58956007
99regulation of sister chromatid cohesion (GO:0007063)2.58915438
100regulation of chromosome segregation (GO:0051983)2.58846725
101cerebral cortex radially oriented cell migration (GO:0021799)2.58293731
102DNA unwinding involved in DNA replication (GO:0006268)2.58205898
103regulation of telomere maintenance via telomerase (GO:0032210)2.56624543
104DNA packaging (GO:0006323)2.55259892
105negative regulation of DNA-dependent DNA replication (GO:2000104)2.54982305
106DNA replication initiation (GO:0006270)2.54955246
107chromatin assembly or disassembly (GO:0006333)2.53387104
108chromosome segregation (GO:0007059)2.52846713
109positive regulation of synapse maturation (GO:0090129)2.52509645
110negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.51892609
111negative regulation of telomere maintenance (GO:0032205)2.51823986
112histone H4-K16 acetylation (GO:0043984)2.51777719
113translesion synthesis (GO:0019985)2.51585503
114histone H4 acetylation (GO:0043967)2.50849425
115positive regulation of mitotic sister chromatid separation (GO:1901970)2.50131996
116positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.50131996
117positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.50131996
118positive regulation of histone H3-K4 methylation (GO:0051571)2.50092386
119regulation of centrosome cycle (GO:0046605)2.50052232
120neuron cell-cell adhesion (GO:0007158)2.49581393
121attachment of spindle microtubules to kinetochore (GO:0008608)2.49387346
122ATP-dependent chromatin remodeling (GO:0043044)2.47797080
123spindle checkpoint (GO:0031577)2.47354150
124histone methylation (GO:0016571)2.46486634
125regulation of mitotic sister chromatid separation (GO:0010965)2.46300597
126regulation of mitotic sister chromatid segregation (GO:0033047)2.46300597
127regulation of sister chromatid segregation (GO:0033045)2.46300597
128histone H4-K8 acetylation (GO:0043982)2.45656230
129histone H4-K5 acetylation (GO:0043981)2.45656230
130chromosome condensation (GO:0030261)2.44712199
131regulation of mRNA splicing, via spliceosome (GO:0048024)2.42283804
132regulation of centrosome duplication (GO:0010824)2.41164715
133mitotic recombination (GO:0006312)2.40957162
134positive T cell selection (GO:0043368)2.40619510
135microtubule nucleation (GO:0007020)2.40580667
136regulation of synapse maturation (GO:0090128)2.40490384
137spindle assembly checkpoint (GO:0071173)2.39777267
138negative regulation of sister chromatid segregation (GO:0033046)2.37995268
139negative regulation of mitotic sister chromatid separation (GO:2000816)2.37995268
140negative regulation of mitotic sister chromatid segregation (GO:0033048)2.37995268
141negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.37995268
142negative regulation of chromosome segregation (GO:0051985)2.37592801
143regulation of mitotic metaphase/anaphase transition (GO:0030071)2.37033521
144poly(A)+ mRNA export from nucleus (GO:0016973)2.36615313
145DNA methylation (GO:0006306)2.36223333
146DNA alkylation (GO:0006305)2.36223333
147mitotic nuclear envelope disassembly (GO:0007077)2.35961010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.32419332
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.25524023
3EZH2_22144423_ChIP-Seq_EOC_Human3.77772738
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.38850996
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.29001003
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.16005180
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.02889038
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.64295039
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.63937431
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.60364808
11ZNF274_21170338_ChIP-Seq_K562_Hela2.54176835
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.50048719
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.44999549
14GBX2_23144817_ChIP-Seq_PC3_Human2.44682529
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.37865207
16ELK1_19687146_ChIP-ChIP_HELA_Human2.22346688
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.13296939
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.11172006
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04241239
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.03982313
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02890737
22VDR_23849224_ChIP-Seq_CD4+_Human1.95464539
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92851502
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89544284
25FUS_26573619_Chip-Seq_HEK293_Human1.80412179
26VDR_22108803_ChIP-Seq_LS180_Human1.70593747
27EWS_26573619_Chip-Seq_HEK293_Human1.70367509
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.66318284
29TAF15_26573619_Chip-Seq_HEK293_Human1.65714859
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64891062
31FOXP3_21729870_ChIP-Seq_TREG_Human1.63098586
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61818323
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61759198
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.58629987
35IRF1_19129219_ChIP-ChIP_H3396_Human1.56797303
36MYC_18940864_ChIP-ChIP_HL60_Human1.52407631
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.50452651
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49915954
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44238718
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43764811
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.43543604
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43363069
43CIITA_25753668_ChIP-Seq_RAJI_Human1.42649309
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41724127
45REST_21632747_ChIP-Seq_MESCs_Mouse1.40442714
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39132991
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38043143
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.37786298
49ER_23166858_ChIP-Seq_MCF-7_Human1.35431130
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34789313
51SOX9_26525672_Chip-Seq_HEART_Mouse1.33843170
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.31639397
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28523927
54RNF2_27304074_Chip-Seq_NSC_Mouse1.28112054
55TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27473938
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26695608
57AR_21909140_ChIP-Seq_LNCAP_Human1.25914036
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25798026
59TCF4_23295773_ChIP-Seq_U87_Human1.25285412
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25117339
61* STAT3_23295773_ChIP-Seq_U87_Human1.24762702
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24748780
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24012770
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24012770
65P300_19829295_ChIP-Seq_ESCs_Human1.23558723
66SMAD4_21799915_ChIP-Seq_A2780_Human1.22971081
67* MYC_18555785_ChIP-Seq_MESCs_Mouse1.21432455
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20513723
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19343899
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18188965
71PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16851277
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.16721961
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16315078
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15907043
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.12340666
76CBP_20019798_ChIP-Seq_JUKART_Human1.11711699
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11711699
78IGF1R_20145208_ChIP-Seq_DFB_Human1.10678826
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10080886
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09563076
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08999885
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08716870
83RARB_27405468_Chip-Seq_BRAIN_Mouse1.08469914
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.08289074
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07526919
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.06868088
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05275721
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05083936
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04171592
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.03985458
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03773227
92JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03673506
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03100893
94REST_18959480_ChIP-ChIP_MESCs_Mouse1.03011560
95KDM5A_27292631_Chip-Seq_BREAST_Human1.02486244
96WDR5_24793694_ChIP-Seq_LNCAP_Human1.01989677
97SRF_21415370_ChIP-Seq_HL-1_Mouse1.01653506
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01489396
99MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99905781
100DCP1A_22483619_ChIP-Seq_HELA_Human0.98333878
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98206924
102NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98169705
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97955490
104YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96483039
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96306004
106PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95532184
107SMAD3_21741376_ChIP-Seq_EPCs_Human0.94749321
108P53_22387025_ChIP-Seq_ESCs_Mouse0.94335932
109TTF2_22483619_ChIP-Seq_HELA_Human0.93493091
110BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93368163
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92777480
112RNF2_27304074_Chip-Seq_ESCs_Mouse0.92763998
113MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92443989
114TP53_22573176_ChIP-Seq_HFKS_Human0.92144823
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91867509
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91597047
117EZH2_27304074_Chip-Seq_ESCs_Mouse0.91301979
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90566499
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90343722
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90094749
121SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89318950
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88815750
123CMYC_18555785_Chip-Seq_ESCs_Mouse0.88509923
124* SOX2_21211035_ChIP-Seq_LN229_Gbm0.87427496
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.87336163
126KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87317328
127* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87291877
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86017674
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85122329
130GABP_19822575_ChIP-Seq_HepG2_Human0.83947861
131TBX3_20139965_ChIP-Seq_ESCs_Mouse0.83707632
132FLI1_21867929_ChIP-Seq_TH2_Mouse0.83650207
133SUZ12_18555785_Chip-Seq_ESCs_Mouse0.83633669
134NFE2_27457419_Chip-Seq_LIVER_Mouse0.83206794
135SALL4_22934838_ChIP-ChIP_CD34+_Human0.83062823
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82792061
137TBX3_20139965_ChIP-Seq_MESCs_Mouse0.82595714
138SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.81581163
139STAT3_18555785_Chip-Seq_ESCs_Mouse0.81419036
140EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81286169
141SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80878565
142TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80473776
143PADI4_21655091_ChIP-ChIP_MCF-7_Human0.79492703
144PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79398038
145KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.79292790
146AR_19668381_ChIP-Seq_PC3_Human0.79060292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation3.49283555
2MP0008057_abnormal_DNA_replication3.26077677
3MP0008877_abnormal_DNA_methylation2.92864571
4MP0010094_abnormal_chromosome_stability2.77511770
5MP0003111_abnormal_nucleus_morphology2.69776716
6MP0002638_abnormal_pupillary_reflex2.65043966
7MP0000569_abnormal_digit_pigmentation2.64424016
8MP0003787_abnormal_imprinting2.62644151
9MP0008058_abnormal_DNA_repair2.58530823
10MP0006292_abnormal_olfactory_placode2.54886535
11MP0002009_preneoplasia2.45051011
12MP0009697_abnormal_copulation2.34038340
13MP0004859_abnormal_synaptic_plasticity2.33422182
14MP0003121_genomic_imprinting2.32315242
15MP0003123_paternal_imprinting2.04474129
16MP0003077_abnormal_cell_cycle2.01268492
17MP0003635_abnormal_synaptic_transmissio1.83300299
18MP0003718_maternal_effect1.73352266
19MP0004147_increased_porphyrin_level1.65109062
20MP0003880_abnormal_central_pattern1.63739547
21MP0006072_abnormal_retinal_apoptosis1.61377224
22MP0008007_abnormal_cellular_replicative1.60530928
23MP0002396_abnormal_hematopoietic_system1.59527894
24MP0002102_abnormal_ear_morphology1.58578663
25MP0002184_abnormal_innervation1.58474385
26MP0003122_maternal_imprinting1.54754615
27MP0000631_abnormal_neuroendocrine_gland1.54404714
28MP0003693_abnormal_embryo_hatching1.50846834
29MP0002063_abnormal_learning/memory/cond1.48940608
30MP0001929_abnormal_gametogenesis1.45755967
31MP0005645_abnormal_hypothalamus_physiol1.44663040
32MP0005075_abnormal_melanosome_morpholog1.42829579
33MP0000372_irregular_coat_pigmentation1.42275471
34MP0001293_anophthalmia1.38964802
35MP0003890_abnormal_embryonic-extraembry1.37714064
36MP0000427_abnormal_hair_cycle1.36451791
37MP0003698_abnormal_male_reproductive1.36378832
38MP0004957_abnormal_blastocyst_morpholog1.36318765
39MP0009745_abnormal_behavioral_response1.34278664
40MP0002210_abnormal_sex_determination1.31945868
41MP0002160_abnormal_reproductive_system1.31584738
42MP0008569_lethality_at_weaning1.30609814
43MP0008932_abnormal_embryonic_tissue1.30057910
44MP0002572_abnormal_emotion/affect_behav1.28604965
45MP0000350_abnormal_cell_proliferation1.27725325
46MP0002163_abnormal_gland_morphology1.26768301
47MP0009046_muscle_twitch1.26534355
48MP0005410_abnormal_fertilization1.25522748
49MP0003786_premature_aging1.25221329
50MP0003567_abnormal_fetal_cardiomyocyte1.24341751
51MP0003937_abnormal_limbs/digits/tail_de1.23796427
52MP0003861_abnormal_nervous_system1.23683213
53MP0000778_abnormal_nervous_system1.18350641
54MP0003646_muscle_fatigue1.17336537
55MP0001529_abnormal_vocalization1.16069705
56MP0002736_abnormal_nociception_after1.12361480
57MP0005174_abnormal_tail_pigmentation1.11159979
58MP0002938_white_spotting1.11013507
59MP0002095_abnormal_skin_pigmentation1.08856569
60MP0002272_abnormal_nervous_system1.07236179
61MP0005646_abnormal_pituitary_gland1.07187415
62MP0002067_abnormal_sensory_capabilities1.06146881
63MP0005389_reproductive_system_phenotype1.05838154
64MP0005551_abnormal_eye_electrophysiolog1.05511453
65MP0004233_abnormal_muscle_weight1.05092736
66MP0002557_abnormal_social/conspecific_i1.03218936
67MP0001145_abnormal_male_reproductive1.02424060
68MP0004133_heterotaxia1.01158852
69MP0001968_abnormal_touch/_nociception1.01055818
70MP0008995_early_reproductive_senescence1.01033365
71MP0002152_abnormal_brain_morphology1.00517642
72MP0000383_abnormal_hair_follicle1.00202571
73MP0005253_abnormal_eye_physiology0.98958163
74MP0003195_calcinosis0.98875218
75MP0002234_abnormal_pharynx_morphology0.98735153
76MP0004808_abnormal_hematopoietic_stem0.98269520
77MP0002084_abnormal_developmental_patter0.98186063
78MP0003943_abnormal_hepatobiliary_system0.98113779
79MP0000653_abnormal_sex_gland0.97971782
80MP0001119_abnormal_female_reproductive0.97622224
81MP0002653_abnormal_ependyma_morphology0.97390563
82MP0001697_abnormal_embryo_size0.97287038
83MP0004145_abnormal_muscle_electrophysio0.95847330
84MP0001502_abnormal_circadian_rhythm0.95296505
85MP0002064_seizures0.94341766
86MP0002928_abnormal_bile_duct0.94271682
87MP0004811_abnormal_neuron_physiology0.93928196
88MP0001486_abnormal_startle_reflex0.93716354
89MP0002085_abnormal_embryonic_tissue0.93138789
90MP0002751_abnormal_autonomic_nervous0.92546310
91MP0000015_abnormal_ear_pigmentation0.92133649
92MP0009703_decreased_birth_body0.91882566
93MP0005394_taste/olfaction_phenotype0.91028076
94MP0005499_abnormal_olfactory_system0.91028076
95MP0001286_abnormal_eye_development0.90353527
96MP0004742_abnormal_vestibular_system0.90087600
97MP0002735_abnormal_chemical_nociception0.89875954
98MP0001764_abnormal_homeostasis0.89835344
99MP0006035_abnormal_mitochondrial_morpho0.89808825
100MP0005391_vision/eye_phenotype0.89599156
101MP0001730_embryonic_growth_arrest0.89270896
102MP0002837_dystrophic_cardiac_calcinosis0.88886349
103MP0001672_abnormal_embryogenesis/_devel0.88537014
104MP0005380_embryogenesis_phenotype0.88537014
105MP0001919_abnormal_reproductive_system0.88402647
106MP0002161_abnormal_fertility/fecundity0.87142340
107MP0003942_abnormal_urinary_system0.86895718
108MP0000313_abnormal_cell_death0.86758037
109MP0002882_abnormal_neuron_morphology0.85833205
110MP0002166_altered_tumor_susceptibility0.85780554
111MP0000703_abnormal_thymus_morphology0.85624076
112MP0000955_abnormal_spinal_cord0.85373165
113MP0008872_abnormal_physiological_respon0.84968375
114MP0005423_abnormal_somatic_nervous0.83384580
115MP0001986_abnormal_taste_sensitivity0.82398974
116MP0002019_abnormal_tumor_incidence0.81005587
117MP0004197_abnormal_fetal_growth/weight/0.80445446
118MP0003984_embryonic_growth_retardation0.79574035
119MP0005379_endocrine/exocrine_gland_phen0.79127201
120MP0003385_abnormal_body_wall0.79101609
121MP0003763_abnormal_thymus_physiology0.77680890
122MP0010307_abnormal_tumor_latency0.76193646
123MP0003755_abnormal_palate_morphology0.76012587
124MP0002752_abnormal_somatic_nervous0.74711242
125MP0005187_abnormal_penis_morphology0.74572292
126MP0002080_prenatal_lethality0.74365785
127MP0001485_abnormal_pinna_reflex0.74042717
128MP0002088_abnormal_embryonic_growth/wei0.73767489
129MP0006276_abnormal_autonomic_nervous0.72895896
130MP0004142_abnormal_muscle_tone0.72720357
131MP0005220_abnormal_exocrine_pancreas0.72564309
132MP0002734_abnormal_mechanical_nocicepti0.71770039
133MP0002006_tumorigenesis0.71631427
134MP0000537_abnormal_urethra_morphology0.71392953
135MP0002233_abnormal_nose_morphology0.71271158
136MP0005386_behavior/neurological_phenoty0.71145587
137MP0004924_abnormal_behavior0.71145587
138MP0005367_renal/urinary_system_phenotyp0.71083287
139MP0000516_abnormal_urinary_system0.71083287
140MP0000647_abnormal_sebaceous_gland0.71011884
141MP0003119_abnormal_digestive_system0.70823095
142MP0008789_abnormal_olfactory_epithelium0.69916914
143MP0003935_abnormal_craniofacial_develop0.69766060
144MP0005395_other_phenotype0.67828169

Predicted human phenotypes

RankGene SetZ-score
1Absent eyebrow (HP:0002223)3.70865398
2Chromsome breakage (HP:0040012)3.37576000
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.34735102
4Pancreatic cysts (HP:0001737)3.13055336
5Volvulus (HP:0002580)3.06774529
6Renal cortical cysts (HP:0000803)2.99597908
7Abnormality of the renal cortex (HP:0011035)2.89673020
8Clubbing of toes (HP:0100760)2.81587599
9Chronic hepatic failure (HP:0100626)2.74772678
10Abnormality of the duodenum (HP:0002246)2.73055626
11Neoplasm of the adrenal cortex (HP:0100641)2.66313411
12Colon cancer (HP:0003003)2.64102826
13Papillary thyroid carcinoma (HP:0002895)2.63492507
14Intestinal atresia (HP:0011100)2.62846993
15Thyroiditis (HP:0100646)2.57770013
16Abnormality of the fingertips (HP:0001211)2.57621950
17Midline defect of the nose (HP:0004122)2.55847284
18Severe combined immunodeficiency (HP:0004430)2.54417041
19Aplasia/Hypoplasia of the sternum (HP:0006714)2.53202568
20Tubulointerstitial nephritis (HP:0001970)2.52885228
21Absent eyelashes (HP:0000561)2.49567460
22Abnormality of midbrain morphology (HP:0002418)2.48143364
23Molar tooth sign on MRI (HP:0002419)2.48143364
24Abnormality of chromosome stability (HP:0003220)2.43398397
25Protruding tongue (HP:0010808)2.42162018
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.42087312
27Morphological abnormality of the middle ear (HP:0008609)2.41885970
28Obsessive-compulsive behavior (HP:0000722)2.40103746
29Bilateral microphthalmos (HP:0007633)2.39413764
30Abnormality of the labia minora (HP:0012880)2.39036945
31Bifid tongue (HP:0010297)2.34775334
32Combined immunodeficiency (HP:0005387)2.32350798
33Febrile seizures (HP:0002373)2.28961309
34Nephroblastoma (Wilms tumor) (HP:0002667)2.26719950
35Glioma (HP:0009733)2.21180244
36Embryonal renal neoplasm (HP:0011794)2.21048606
37B lymphocytopenia (HP:0010976)2.20419937
38Abnormal hair whorl (HP:0010721)2.19836477
39Tented upper lip vermilion (HP:0010804)2.18413878
40Truncal obesity (HP:0001956)2.18306768
41Abnormality of B cell number (HP:0010975)2.17944289
42Nephronophthisis (HP:0000090)2.15249796
43Skull defect (HP:0001362)2.11931154
44Abnormal biliary tract physiology (HP:0012439)2.11417148
45Bile duct proliferation (HP:0001408)2.11417148
46Ectopic kidney (HP:0000086)2.10121813
47Rhabdomyosarcoma (HP:0002859)2.09317034
48Ependymoma (HP:0002888)2.08151287
49Focal motor seizures (HP:0011153)2.07980877
50Triphalangeal thumb (HP:0001199)2.07563637
51Abnormal lung lobation (HP:0002101)2.05950157
52Impaired smooth pursuit (HP:0007772)2.05586553
53Oligodactyly (hands) (HP:0001180)2.04289482
54Astrocytoma (HP:0009592)2.02643798
55Abnormality of the astrocytes (HP:0100707)2.02643798
56Cerebellar dysplasia (HP:0007033)2.02253778
57Septo-optic dysplasia (HP:0100842)2.01303149
58Supernumerary spleens (HP:0009799)2.00302119
59Astigmatism (HP:0000483)1.99860227
60Pancreatic fibrosis (HP:0100732)1.99832432
61Abnormality of chromosome segregation (HP:0002916)1.99526189
62Absent radius (HP:0003974)1.98908799
63Deep philtrum (HP:0002002)1.98248220
64Abnormality of the renal collecting system (HP:0004742)1.97914911
65Patellar aplasia (HP:0006443)1.97842224
66Medulloblastoma (HP:0002885)1.97148035
67Increased nuchal translucency (HP:0010880)1.95051771
68Dynein arm defect of respiratory motile cilia (HP:0012255)1.93947909
69Absent/shortened dynein arms (HP:0200106)1.93947909
70Absent thumb (HP:0009777)1.93465073
71Highly arched eyebrow (HP:0002553)1.93184989
72Genital tract atresia (HP:0001827)1.92903032
73Meckel diverticulum (HP:0002245)1.90659112
74Deep palmar crease (HP:0006191)1.89446554
75True hermaphroditism (HP:0010459)1.88307481
76Abnormality of the pons (HP:0007361)1.87591196
77Vaginal atresia (HP:0000148)1.87232514
78Aplasia involving forearm bones (HP:0009822)1.86389333
79Absent forearm bone (HP:0003953)1.86389333
80Abnormality of the ileum (HP:0001549)1.85732436
81Postaxial foot polydactyly (HP:0001830)1.84748286
82Acute myeloid leukemia (HP:0004808)1.84618937
83Optic nerve hypoplasia (HP:0000609)1.83149390
84Abnormality of ocular smooth pursuit (HP:0000617)1.83017841
85Congenital stationary night blindness (HP:0007642)1.82838480
86Gastroesophageal reflux (HP:0002020)1.81837066
87Epileptic encephalopathy (HP:0200134)1.80718921
88Oligohydramnios (HP:0001562)1.79788023
89Aplasia/Hypoplasia of the patella (HP:0006498)1.79514727
90Gait imbalance (HP:0002141)1.79332618
91Hypoplasia of the pons (HP:0012110)1.78043037
92Acute lymphatic leukemia (HP:0006721)1.77897887
93Panhypogammaglobulinemia (HP:0003139)1.77334336
94Long clavicles (HP:0000890)1.77170023
95Congenital primary aphakia (HP:0007707)1.77059418
96Pancreatic islet-cell hyperplasia (HP:0004510)1.75027548
97Cystic liver disease (HP:0006706)1.74702384
98Medial flaring of the eyebrow (HP:0010747)1.74651244
99Thickened helices (HP:0000391)1.74237828
100Sclerocornea (HP:0000647)1.73879298
101Type II lissencephaly (HP:0007260)1.73836962
102Birth length less than 3rd percentile (HP:0003561)1.73782834
103Myelodysplasia (HP:0002863)1.72809439
104Arteriovenous malformation (HP:0100026)1.72529523
105Abnormality of the carotid arteries (HP:0005344)1.72112352
106Progressive cerebellar ataxia (HP:0002073)1.71961807
107Dandy-Walker malformation (HP:0001305)1.71617526
108Abnormality of DNA repair (HP:0003254)1.71034591
109Abnormality of the preputium (HP:0100587)1.70780353
110Optic nerve coloboma (HP:0000588)1.70746778
111Gastrointestinal atresia (HP:0002589)1.70693254
112Aplasia/Hypoplasia of the tongue (HP:0010295)1.69122773
113Small hand (HP:0200055)1.68602825
114Embryonal neoplasm (HP:0002898)1.68594887
115Facial cleft (HP:0002006)1.68302481
116Abnormality of the renal medulla (HP:0100957)1.67255727
117Cystic hygroma (HP:0000476)1.66493924
118Asplenia (HP:0001746)1.66237028
119Hyperventilation (HP:0002883)1.66068817
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.65909400
121Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65093703
122Oligodactyly (HP:0012165)1.64776512
123Anophthalmia (HP:0000528)1.64668483
124Methylmalonic acidemia (HP:0002912)1.64291480
125Abnormality of the septum pellucidum (HP:0007375)1.63134567
126Cafe-au-lait spot (HP:0000957)1.62446605
127Focal seizures (HP:0007359)1.61710193
128Poor coordination (HP:0002370)1.61305402
129Narrow forehead (HP:0000341)1.61108659
130Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.60880420
131Neoplasm of the tracheobronchial system (HP:0100552)1.60366051
132Duodenal stenosis (HP:0100867)1.60092952
133Small intestinal stenosis (HP:0012848)1.60092952
134Aplasia/Hypoplasia of the spleen (HP:0010451)1.59921080
135Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.59060301
136Short 4th metacarpal (HP:0010044)1.59060301
137Long palpebral fissure (HP:0000637)1.58725307
138Micropenis (HP:0000054)1.58148486
139Growth hormone deficiency (HP:0000824)1.55247524
140Abnormality of the metopic suture (HP:0005556)1.55157169
141Small epiphyses (HP:0010585)1.54830147
142Neoplasm of the oral cavity (HP:0100649)1.53539919
143Nephrogenic diabetes insipidus (HP:0009806)1.52317294
144Heterotopia (HP:0002282)1.52065208
145Preaxial hand polydactyly (HP:0001177)1.51384671
146Pointed chin (HP:0000307)1.50711523
147Stereotypic behavior (HP:0000733)1.49908493
148Hyperacusis (HP:0010780)1.49560432
149Broad-based gait (HP:0002136)1.49304213
150Abnormality of the intervertebral disk (HP:0005108)1.48802693
151Duplicated collecting system (HP:0000081)1.48150920
152Gaze-evoked nystagmus (HP:0000640)1.47515967
153Thyroid carcinoma (HP:0002890)1.46525210
154Sloping forehead (HP:0000340)1.46374589
155Autism (HP:0000717)1.46239908

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.79680457
2FRK3.92402681
3CDC73.67267997
4SIK32.98315496
5KSR12.79892320
6NTRK22.72545858
7NTRK32.62899750
8BRAF2.37906829
9SGK22.27088077
10BMPR1B2.21450812
11BRD42.20911412
12SRPK12.17109984
13MAP4K22.16561471
14ACVR1B1.95790164
15TNIK1.79534329
16EIF2AK31.73424398
17TTK1.71685416
18WNK31.71438169
19NEK21.70055872
20CDK121.69605621
21CASK1.60799963
22MKNK21.59809106
23ATR1.56564036
24PBK1.55098476
25MAP3K41.50892822
26SGK31.46200919
27CHEK21.44793735
28PNCK1.40179530
29TRIM281.39662023
30MARK11.38274312
31SGK4941.38164022
32SGK2231.38164022
33STK391.37562156
34MAPK131.36490893
35MKNK11.32964961
36CHEK11.32155267
37EIF2AK11.29290587
38PLK11.27050080
39PLK31.23445006
40ERBB31.20339340
41ATM1.10682256
42WEE11.10577123
43INSRR1.07925535
44TAF11.06393433
45BCR1.05223860
46NLK1.05217441
47BRSK11.04544860
48VRK11.04499107
49WNK41.03760721
50PLK41.01594468
51FGFR21.01094117
52YES11.00073415
53MAP2K71.00049989
54TLK10.99383992
55BRSK20.98287607
56CCNB10.96945837
57CDK30.90889525
58PLK20.87795351
59CDK20.86484030
60CDK10.86277143
61NTRK10.85731181
62MINK10.85668448
63AURKB0.85455809
64CAMKK20.84108886
65TEC0.81305913
66STK30.80257873
67CSNK1G10.79851740
68SIK20.79775147
69PRKD30.78541166
70CAMK1G0.78305807
71EPHA40.74512615
72UHMK10.73746778
73GRK10.73722228
74TSSK60.72710976
75TAOK30.71947314
76CDK40.71487077
77PASK0.71220552
78SGK10.68801817
79MAP3K100.68495832
80RPS6KB10.67833548
81STK40.66492460
82CDK90.66403014
83CLK10.66373742
84CDC42BPA0.66301424
85ZAK0.66019807
86EIF2AK20.62128182
87GSK3B0.60651868
88MELK0.60598775
89CDK80.59970991
90FLT30.58941568
91NUAK10.58790238
92DYRK1A0.58769719
93MAPK140.57397547
94PINK10.56133722
95ADRBK20.55426289
96CAMK1D0.55160795
97MST40.54707014
98LATS10.53992468
99CDK70.53855837
100PRKDC0.53097021
101CSNK1G20.53045917
102EEF2K0.52714654
103TXK0.52447699
104TYRO30.51620472
105PTK2B0.51334568
106CDK180.50418287
107RPS6KB20.50200668
108AKT10.49762994
109FES0.48566389
110CSNK1G30.48363604
111STK160.47813855
112MAPK100.47251105
113STK38L0.46080478
114ALK0.45975131
115ICK0.45353413
116PRKCG0.44987092
117TGFBR10.44601444
118CDK50.43932453
119NEK10.43913297
120PRKAA10.43525305
121MAP3K90.42400975
122RPS6KA50.41159082
123SCYL20.41153339
124CSNK1A1L0.40593245
125STK380.40268645
126ERBB40.40147412
127PRKCB0.39658328
128MAP3K60.39167216
129PAK30.38909913
130CSNK1D0.38718826
131MAP3K20.38646420
132PRPF4B0.38451874
133PAK60.38403606
134CSNK1E0.38324090
135MARK30.38281255
136MAPK80.37969172
137BUB10.37664603
138DYRK30.37456665
139RPS6KA30.37412492
140PKN10.32348382
141CSNK2A20.31724957
142OXSR10.31693764
143RPS6KA40.31239457
144WNK10.29122881

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.65663522
2Fanconi anemia pathway_Homo sapiens_hsa034602.26545617
3DNA replication_Homo sapiens_hsa030302.10570119
4Cell cycle_Homo sapiens_hsa041102.10239242
5mRNA surveillance pathway_Homo sapiens_hsa030152.10053339
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00144918
7Protein export_Homo sapiens_hsa030601.90496181
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87628932
9Mismatch repair_Homo sapiens_hsa034301.85508170
10Homologous recombination_Homo sapiens_hsa034401.85079497
11Long-term potentiation_Homo sapiens_hsa047201.82833866
12Selenocompound metabolism_Homo sapiens_hsa004501.75482627
13Non-homologous end-joining_Homo sapiens_hsa034501.75186833
14Spliceosome_Homo sapiens_hsa030401.67164756
15RNA transport_Homo sapiens_hsa030131.66505750
16Oocyte meiosis_Homo sapiens_hsa041141.65125003
17Butanoate metabolism_Homo sapiens_hsa006501.62050898
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60890423
19Propanoate metabolism_Homo sapiens_hsa006401.60469686
20Morphine addiction_Homo sapiens_hsa050321.58077940
21Circadian entrainment_Homo sapiens_hsa047131.56831519
22Glutamatergic synapse_Homo sapiens_hsa047241.48160219
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47311073
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.44284708
25RNA degradation_Homo sapiens_hsa030181.44052331
26Amphetamine addiction_Homo sapiens_hsa050311.41827655
27Long-term depression_Homo sapiens_hsa047301.39755562
28Pyrimidine metabolism_Homo sapiens_hsa002401.38040384
29Base excision repair_Homo sapiens_hsa034101.34253924
30Nucleotide excision repair_Homo sapiens_hsa034201.32372839
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31731052
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31100243
33Olfactory transduction_Homo sapiens_hsa047401.29807694
34Basal transcription factors_Homo sapiens_hsa030221.29606015
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27702908
36Phototransduction_Homo sapiens_hsa047441.27393990
37GABAergic synapse_Homo sapiens_hsa047271.25291308
38Dopaminergic synapse_Homo sapiens_hsa047281.23388066
39Alcoholism_Homo sapiens_hsa050341.19931611
40Colorectal cancer_Homo sapiens_hsa052101.19816580
41Caffeine metabolism_Homo sapiens_hsa002321.18354453
42Glioma_Homo sapiens_hsa052141.17180410
43Nitrogen metabolism_Homo sapiens_hsa009101.15724932
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14966766
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11672908
46p53 signaling pathway_Homo sapiens_hsa041151.10086191
47Serotonergic synapse_Homo sapiens_hsa047261.07956330
48Endometrial cancer_Homo sapiens_hsa052131.06829637
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05578725
50Insulin secretion_Homo sapiens_hsa049111.04742907
51ErbB signaling pathway_Homo sapiens_hsa040121.04604302
52Proteasome_Homo sapiens_hsa030501.04512842
53Synaptic vesicle cycle_Homo sapiens_hsa047211.01728129
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.01639551
55Cholinergic synapse_Homo sapiens_hsa047251.00468861
56Non-small cell lung cancer_Homo sapiens_hsa052231.00024671
57Taste transduction_Homo sapiens_hsa047420.99402275
58Oxytocin signaling pathway_Homo sapiens_hsa049210.96568763
59Wnt signaling pathway_Homo sapiens_hsa043100.96393143
60Lysine degradation_Homo sapiens_hsa003100.94334624
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93754143
62Type II diabetes mellitus_Homo sapiens_hsa049300.91713791
63Circadian rhythm_Homo sapiens_hsa047100.89788096
64Basal cell carcinoma_Homo sapiens_hsa052170.89767912
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89764966
66Calcium signaling pathway_Homo sapiens_hsa040200.88153664
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87932713
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87788732
69MicroRNAs in cancer_Homo sapiens_hsa052060.87114322
70Thyroid cancer_Homo sapiens_hsa052160.84117303
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83308697
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.83283805
73cAMP signaling pathway_Homo sapiens_hsa040240.82062725
74Primary immunodeficiency_Homo sapiens_hsa053400.81510523
75Dorso-ventral axis formation_Homo sapiens_hsa043200.80154352
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79264823
77T cell receptor signaling pathway_Homo sapiens_hsa046600.79082473
78Chronic myeloid leukemia_Homo sapiens_hsa052200.78920448
79Renin secretion_Homo sapiens_hsa049240.78603766
80mTOR signaling pathway_Homo sapiens_hsa041500.77824373
81Salivary secretion_Homo sapiens_hsa049700.77594769
82Estrogen signaling pathway_Homo sapiens_hsa049150.77442344
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77285818
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77068833
85Hedgehog signaling pathway_Homo sapiens_hsa043400.75262214
86Axon guidance_Homo sapiens_hsa043600.74503434
87Melanogenesis_Homo sapiens_hsa049160.73715374
88Inositol phosphate metabolism_Homo sapiens_hsa005620.73435793
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73341896
90Cocaine addiction_Homo sapiens_hsa050300.73332644
91Renal cell carcinoma_Homo sapiens_hsa052110.72007200
92RNA polymerase_Homo sapiens_hsa030200.71943933
93Steroid biosynthesis_Homo sapiens_hsa001000.70258310
94MAPK signaling pathway_Homo sapiens_hsa040100.70218915
95Systemic lupus erythematosus_Homo sapiens_hsa053220.69873690
96Prostate cancer_Homo sapiens_hsa052150.69785081
97HTLV-I infection_Homo sapiens_hsa051660.67814624
98Peroxisome_Homo sapiens_hsa041460.67681241
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67502246
100Pancreatic cancer_Homo sapiens_hsa052120.67401826
101GnRH signaling pathway_Homo sapiens_hsa049120.67248376
102Choline metabolism in cancer_Homo sapiens_hsa052310.66363329
103Regulation of autophagy_Homo sapiens_hsa041400.66261852
104Tryptophan metabolism_Homo sapiens_hsa003800.62877214
105Gap junction_Homo sapiens_hsa045400.61970566
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.61382451
107Purine metabolism_Homo sapiens_hsa002300.60769845
108Epstein-Barr virus infection_Homo sapiens_hsa051690.59503910
109Gastric acid secretion_Homo sapiens_hsa049710.59378626
110Fatty acid metabolism_Homo sapiens_hsa012120.58756862
111One carbon pool by folate_Homo sapiens_hsa006700.58266066
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57536497
113FoxO signaling pathway_Homo sapiens_hsa040680.57091300
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56853812
115Hippo signaling pathway_Homo sapiens_hsa043900.56585950
116Viral carcinogenesis_Homo sapiens_hsa052030.56484852
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.54898023
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54864445
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.54295894
120Melanoma_Homo sapiens_hsa052180.54214183
121Glucagon signaling pathway_Homo sapiens_hsa049220.54144444
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53457347
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53155469
124Acute myeloid leukemia_Homo sapiens_hsa052210.51483787
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.49791920
126Pyruvate metabolism_Homo sapiens_hsa006200.48873679
127Linoleic acid metabolism_Homo sapiens_hsa005910.48596727
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47564973
129TGF-beta signaling pathway_Homo sapiens_hsa043500.47348347
130ABC transporters_Homo sapiens_hsa020100.44945571
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44514353
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40676231
133Huntingtons disease_Homo sapiens_hsa050160.40627565
134Ether lipid metabolism_Homo sapiens_hsa005650.40521657
135Metabolic pathways_Homo sapiens_hsa011000.39168597
136Fatty acid degradation_Homo sapiens_hsa000710.37029236
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35564626
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33547137
139Oxidative phosphorylation_Homo sapiens_hsa001900.32412291
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.31583746
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31243249
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31134613
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30780481
144Fatty acid biosynthesis_Homo sapiens_hsa000610.29623071
145Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29070300
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.28234950
147N-Glycan biosynthesis_Homo sapiens_hsa005100.28133878
148Parkinsons disease_Homo sapiens_hsa050120.27268826
149Fatty acid elongation_Homo sapiens_hsa000620.26771787
150Ribosome_Homo sapiens_hsa030100.26139887
151beta-Alanine metabolism_Homo sapiens_hsa004100.21618507
152Glycerolipid metabolism_Homo sapiens_hsa005610.20651179
153Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18699496
154Retinol metabolism_Homo sapiens_hsa008300.17347840
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.16585500

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