MPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)7.99839389
2ribosomal small subunit assembly (GO:0000028)7.85128646
3thrombin receptor signaling pathway (GO:0070493)7.39743813
4platelet dense granule organization (GO:0060155)6.69603590
5aggressive behavior (GO:0002118)6.67020024
6endothelium development (GO:0003158)5.78015155
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.77347165
8viral transcription (GO:0019083)5.75408318
9negative regulation of erythrocyte differentiation (GO:0045647)5.58838143
10regulation of female receptivity (GO:0045924)5.57235169
11translational termination (GO:0006415)5.55362943
12megakaryocyte development (GO:0035855)5.41630239
13antigen processing and presentation via MHC class Ib (GO:0002475)5.25149671
14pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.23998415
15response to interferon-beta (GO:0035456)5.06632215
16female mating behavior (GO:0060180)4.97086670
17endosome to melanosome transport (GO:0035646)4.92519088
18endosome to pigment granule transport (GO:0043485)4.92519088
19angiogenesis involved in wound healing (GO:0060055)4.90239921
20mature B cell differentiation involved in immune response (GO:0002313)4.89863224
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.80330204
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.80330204
23neutrophil activation involved in immune response (GO:0002283)4.77211075
24translational elongation (GO:0006414)4.76617711
25ribosomal small subunit biogenesis (GO:0042274)4.75970167
26protein neddylation (GO:0045116)4.71808968
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.69063355
28response to interferon-alpha (GO:0035455)4.68916484
29cotranslational protein targeting to membrane (GO:0006613)4.57780640
30protein targeting to ER (GO:0045047)4.54731490
31DNA deamination (GO:0045006)4.51687990
32blood coagulation, intrinsic pathway (GO:0007597)4.51245606
33maturation of SSU-rRNA (GO:0030490)4.50854034
34regulation of integrin activation (GO:0033623)4.36110636
35pyrimidine nucleotide catabolic process (GO:0006244)4.36105762
36protein localization to endoplasmic reticulum (GO:0070972)4.33539029
37regulation of platelet activation (GO:0010543)4.32765881
38establishment of protein localization to endoplasmic reticulum (GO:0072599)4.32499188
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.32463830
40viral life cycle (GO:0019058)4.24516470
41pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.20757036
42heparin metabolic process (GO:0030202)4.17889482
43heparin biosynthetic process (GO:0030210)4.17889482
44purinergic nucleotide receptor signaling pathway (GO:0035590)4.11616467
45lymph node development (GO:0048535)4.06669124
46cellular protein complex disassembly (GO:0043624)4.03647656
47secretory granule organization (GO:0033363)4.02273828
48platelet aggregation (GO:0070527)3.92866246
49positive regulation of B cell differentiation (GO:0045579)3.92742661
50antigen processing and presentation of endogenous antigen (GO:0019883)3.90550932
51autophagic vacuole fusion (GO:0000046)3.90109190
52negative regulation of thymocyte apoptotic process (GO:0070244)3.89486998
53lymphoid progenitor cell differentiation (GO:0002320)3.87480150
54regulation of platelet aggregation (GO:0090330)3.86653010
55positive regulation of gamma-delta T cell activation (GO:0046645)3.82491641
56translational initiation (GO:0006413)3.79282514
57grooming behavior (GO:0007625)3.71024638
58protein complex disassembly (GO:0043241)3.67916026
59necroptotic process (GO:0070266)3.66025187
60mature B cell differentiation (GO:0002335)3.64504299
61positive regulation of mast cell activation (GO:0033005)3.63190636
62deoxyribonucleotide catabolic process (GO:0009264)3.61259712
63regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.61046964
64negative regulation of stress fiber assembly (GO:0051497)3.59674690
65telomere maintenance via semi-conservative replication (GO:0032201)3.53510659
66L-fucose metabolic process (GO:0042354)3.52525179
67L-fucose catabolic process (GO:0042355)3.52525179
68fucose catabolic process (GO:0019317)3.52525179
69Peyers patch development (GO:0048541)3.52084728
70mucosal-associated lymphoid tissue development (GO:0048537)3.52084728
71fusion of sperm to egg plasma membrane (GO:0007342)3.51837394
72regulation of natural killer cell differentiation (GO:0032823)3.46818364
73G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.45167828
74immunoglobulin mediated immune response (GO:0016064)3.45053743
75negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.45001886
76respiratory chain complex IV assembly (GO:0008535)3.44984430
77lipoxygenase pathway (GO:0019372)3.44315498
78deoxyribose phosphate catabolic process (GO:0046386)3.42609404
79positive regulation of systemic arterial blood pressure (GO:0003084)3.41777111
80defense response to protozoan (GO:0042832)3.41307516
81macromolecular complex disassembly (GO:0032984)3.40080813
82activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.39810656
83nuclear-transcribed mRNA catabolic process (GO:0000956)3.38646258
84positive regulation of T cell cytokine production (GO:0002726)3.38114329
85B cell mediated immunity (GO:0019724)3.37711708
86T cell homeostasis (GO:0043029)3.36092263
87negative regulation of viral entry into host cell (GO:0046597)3.33576838
88cyclooxygenase pathway (GO:0019371)3.32676341
89negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.32079463
90embryonic hemopoiesis (GO:0035162)3.31802131
91response to protozoan (GO:0001562)3.27724279
92purine-containing compound salvage (GO:0043101)3.27652957
93mRNA catabolic process (GO:0006402)3.26416762
94Arp2/3 complex-mediated actin nucleation (GO:0034314)3.26206628
95negative regulation of viral genome replication (GO:0045071)3.20908743
96positive regulation of T cell mediated cytotoxicity (GO:0001916)3.18772437
97negative regulation of T cell apoptotic process (GO:0070233)3.16824794
98positive regulation of granulocyte differentiation (GO:0030854)3.14777933
99response to type I interferon (GO:0034340)3.11337830
100phospholipid scrambling (GO:0017121)3.10634121
101cellular response to type I interferon (GO:0071357)3.10615108
102type I interferon signaling pathway (GO:0060337)3.10615108
103cellular response to thyroid hormone stimulus (GO:0097067)3.07686712
104phagocytosis, engulfment (GO:0006911)3.07058369
105DNA strand elongation involved in DNA replication (GO:0006271)3.06698257
106regulation of T cell mediated cytotoxicity (GO:0001914)3.06089924
107CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.06007392
108mast cell activation (GO:0045576)3.05490222
109purinergic receptor signaling pathway (GO:0035587)3.04501809
110maternal behavior (GO:0042711)3.04302976
111regulation of gamma-delta T cell differentiation (GO:0045586)3.04201198
112regulation of transmission of nerve impulse (GO:0051969)3.04081504
113RNA catabolic process (GO:0006401)3.03019927
114ribosomal large subunit biogenesis (GO:0042273)3.01469299
115purine nucleotide salvage (GO:0032261)3.01353044
116telomere maintenance via recombination (GO:0000722)3.00429898
117negative regulation of actin filament bundle assembly (GO:0032232)2.99835393
118DNA strand elongation (GO:0022616)2.98652445
119regulation of erythrocyte differentiation (GO:0045646)2.98599849
120positive regulation of natural killer cell differentiation (GO:0032825)2.97774711
121T-helper 1 type immune response (GO:0042088)2.96587545
122negative regulation of bone mineralization (GO:0030502)2.95706956
123protein targeting to membrane (GO:0006612)2.94287631
124monoamine transport (GO:0015844)2.94041459
125negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.93983052
126negative regulation of T-helper cell differentiation (GO:0045623)2.93983052
127organelle membrane fusion (GO:0090174)2.91817521
128regulation of mast cell activation (GO:0033003)2.91128837
129regulation of regulatory T cell differentiation (GO:0045589)2.88058745
130regulation of mast cell degranulation (GO:0043304)2.87740702
131xenobiotic catabolic process (GO:0042178)2.87141962
132positive regulation of antigen processing and presentation (GO:0002579)2.87053774
133adenosine receptor signaling pathway (GO:0001973)2.85771700
134hyperosmotic salinity response (GO:0042538)2.85618145
135neutrophil activation (GO:0042119)2.85220134
136ribonucleoprotein complex biogenesis (GO:0022613)2.84900987
137leukocyte migration involved in inflammatory response (GO:0002523)2.82657637
138IMP metabolic process (GO:0046040)2.82033866
139regulation of penile erection (GO:0060405)2.81183373
140positive regulation of mast cell degranulation (GO:0043306)2.77362381
141positive regulation of mast cell activation involved in immune response (GO:0033008)2.77362381
142programmed necrotic cell death (GO:0097300)2.76159213
143regulation of mast cell activation involved in immune response (GO:0033006)2.76004178
144plasma membrane fusion (GO:0045026)2.75585755
145actin nucleation (GO:0045010)2.75557867
146regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.74448504
147myeloid cell development (GO:0061515)2.74446399
148pigment granule organization (GO:0048753)2.74023267
149positive regulation of endothelial cell differentiation (GO:0045603)2.73793630
150regulation of gamma-delta T cell activation (GO:0046643)2.73728545
151regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.73627095
152negative regulation of norepinephrine secretion (GO:0010700)2.72875658
153melanosome organization (GO:0032438)2.72725661
154IMP biosynthetic process (GO:0006188)2.72295453
155lipopolysaccharide biosynthetic process (GO:0009103)2.72283488
156pyrimidine nucleoside catabolic process (GO:0046135)2.71550393
157parental behavior (GO:0060746)2.71040665
158pseudouridine synthesis (GO:0001522)2.71022621
159deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.70833888
160B cell activation involved in immune response (GO:0002312)2.70380674
161positive regulation of vasculogenesis (GO:2001214)2.69839287
1622-deoxyribonucleotide metabolic process (GO:0009394)2.69661471
163regulation of lipoprotein metabolic process (GO:0050746)2.68658398
164negative regulation of lymphocyte apoptotic process (GO:0070229)2.68619885
165regulation of integrin-mediated signaling pathway (GO:2001044)2.68522923
166regulation of B cell differentiation (GO:0045577)2.68430832
167L-phenylalanine catabolic process (GO:0006559)2.67999496
168erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.67999496
169deoxyribose phosphate metabolic process (GO:0019692)2.67795358
170triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.67170442
171membrane invagination (GO:0010324)2.66959535
172positive regulation of respiratory burst (GO:0060267)2.66742182
173regulation of B cell apoptotic process (GO:0002902)2.66549420
174cytokine production involved in immune response (GO:0002367)2.66301695
175cytochrome complex assembly (GO:0017004)2.64160939
176histamine secretion (GO:0001821)2.62358666
177seminiferous tubule development (GO:0072520)2.62346866
178homotypic cell-cell adhesion (GO:0034109)2.61097783
179nucleotide salvage (GO:0043173)2.59563061
180regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.59424143
181negative regulation of response to food (GO:0032096)2.58422005
182negative regulation of appetite (GO:0032099)2.58422005
183phosphatidylinositol acyl-chain remodeling (GO:0036149)2.57639253
184cellular response to exogenous dsRNA (GO:0071360)2.57283200
185regulation of RIG-I signaling pathway (GO:0039535)2.54849210
186pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.54798532
187positive regulation of hemostasis (GO:1900048)2.53299042
188positive regulation of blood coagulation (GO:0030194)2.53299042
189negative regulation of heart rate (GO:0010459)2.52441943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human5.54258599
2E2F7_22180533_ChIP-Seq_HELA_Human4.04634767
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.88282072
4SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.87418284
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.57812777
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.35620216
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.33029004
8NOTCH1_21737748_ChIP-Seq_TLL_Human3.21249467
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.20545355
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.13358746
11TAL1_20887958_ChIP-Seq_HPC-7_Mouse3.06723427
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97639653
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.93806190
14FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.88456497
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.86368756
16LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.76088829
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.73987099
18* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.71829041
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.59758710
20GATA1_19941826_ChIP-Seq_K562_Human2.46332867
21ERG_20887958_ChIP-Seq_HPC-7_Mouse2.36285295
22LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.28998036
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.25996590
24HOXB4_20404135_ChIP-ChIP_EML_Mouse2.23015227
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20970856
26SPI1_23547873_ChIP-Seq_NB4_Human2.20313939
27SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.18574353
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.15892676
29MYC_22102868_ChIP-Seq_BL_Human2.14034201
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13962112
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.12421641
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.09319456
33IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03895786
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99099955
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.98744330
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93159843
37GATA2_19941826_ChIP-Seq_K562_Human1.92939083
38GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.87542186
39VDR_23849224_ChIP-Seq_CD4+_Human1.86398140
40VDR_21846776_ChIP-Seq_THP-1_Human1.86229356
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.85845325
42GATA1_22025678_ChIP-Seq_K562_Human1.84973300
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.84266952
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82952487
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.82394335
46FOXP3_21729870_ChIP-Seq_TREG_Human1.79006555
47GATA1_22383799_ChIP-Seq_G1ME_Mouse1.78326481
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77390539
49GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.76381324
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.75699948
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75017823
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.72893285
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.68925751
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68218809
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64690840
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.63719744
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.63093646
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62408349
59MYB_26560356_Chip-Seq_TH2_Human1.58358510
60XRN2_22483619_ChIP-Seq_HELA_Human1.56478374
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.55520452
62VDR_24763502_ChIP-Seq_THP-1_Human1.52466944
63* BCL6_27268052_Chip-Seq_Bcells_Human1.52045202
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51094286
65MYB_26560356_Chip-Seq_TH1_Human1.49014055
66MAF_26560356_Chip-Seq_TH1_Human1.48974690
67TCF7_22412390_ChIP-Seq_EML_Mouse1.46898437
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46803789
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43195880
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.39430005
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39373439
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39225677
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38839865
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.38508306
75CIITA_25753668_ChIP-Seq_RAJI_Human1.36673233
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34991613
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33597771
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33186867
79UTX_26944678_Chip-Seq_JUKART_Human1.30470653
80RUNX_20019798_ChIP-Seq_JUKART_Human1.29840328
81SPI1_20517297_ChIP-Seq_HL60_Human1.29493353
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27734236
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27143042
84P300_27268052_Chip-Seq_Bcells_Human1.26316125
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25654133
86GATA3_26560356_Chip-Seq_TH2_Human1.24940034
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.23983745
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23967847
89BCOR_27268052_Chip-Seq_Bcells_Human1.23518662
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22151174
91* GABP_19822575_ChIP-Seq_HepG2_Human1.22089680
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.20029528
93* ETS1_22383799_ChIP-Seq_G1ME_Mouse1.19745403
94CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19129783
95GATA3_27048872_Chip-Seq_THYMUS_Human1.17651999
96* NANOG_20526341_ChIP-Seq_ESCs_Human1.16662971
97VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16273366
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15959477
99NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15944795
100ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13962890
101* HTT_18923047_ChIP-ChIP_STHdh_Human1.13695067
102PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13647598
103AR_20517297_ChIP-Seq_VCAP_Human1.13203787
104TTF2_22483619_ChIP-Seq_HELA_Human1.12448618
105THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11430131
106PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10195680
107GATA3_21878914_ChIP-Seq_MCF-7_Human1.08594702
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08515836
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08153054
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.08072495
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07244112
112GATA1_19941827_ChIP-Seq_MEL86_Mouse1.06472527
113ELK1_19687146_ChIP-ChIP_HELA_Human1.06272827
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04537850
115IRF8_27001747_Chip-Seq_BMDM_Mouse1.03987392
116E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03300344
117NCOR1_26117541_ChIP-Seq_K562_Human1.02371999
118STAT1_20625510_ChIP-Seq_HELA_Human1.01628432
119ERG_20517297_ChIP-Seq_VCAP_Human1.01443519
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01222283
121* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00906912
122ZNF263_19887448_ChIP-Seq_K562_Human0.99719415
123IGF1R_20145208_ChIP-Seq_DFB_Human0.99501521
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98791450
125PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98588623
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97081050
127DCP1A_22483619_ChIP-Seq_HELA_Human0.97061701
128EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95525886
129RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95135759
130FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93715088
131EWS_26573619_Chip-Seq_HEK293_Human0.92752592
132MAF_26560356_Chip-Seq_TH2_Human0.92449957
133SPI1_23127762_ChIP-Seq_K562_Human0.91989238
134BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91950816
135* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91805788
136KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.91582602
137CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91500381
138E2F1_21310950_ChIP-Seq_MCF-7_Human0.91104428
139STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.91076814
140CTCF_26484167_Chip-Seq_Bcells_Mouse0.90909102
141IRF1_19129219_ChIP-ChIP_H3396_Human0.90908736
142RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89728849
143* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89532060
144SALL4_22934838_ChIP-ChIP_CD34+_Human0.89388736
145CTCF_20526341_ChIP-Seq_ESCs_Human0.88058374
146YY1_22570637_ChIP-Seq_MALME-3M_Human0.87289763
147CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86394174
148CREB1_15753290_ChIP-ChIP_HEK293T_Human0.86180284

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.28966560
2MP0008004_abnormal_stomach_pH3.89938521
3MP0005174_abnormal_tail_pigmentation3.34030401
4MP0004147_increased_porphyrin_level3.26241231
5MP0005397_hematopoietic_system_phenotyp3.21577163
6MP0001545_abnormal_hematopoietic_system3.21577163
7* MP0004808_abnormal_hematopoietic_stem3.20062808
8MP0005464_abnormal_platelet_physiology3.18110284
9MP0001835_abnormal_antigen_presentation3.13859563
10MP0005075_abnormal_melanosome_morpholog3.04468335
11MP0000465_gastrointestinal_hemorrhage2.87030685
12MP0005646_abnormal_pituitary_gland2.81342850
13MP0000685_abnormal_immune_system2.78680537
14MP0009785_altered_susceptibility_to2.77720227
15MP0005671_abnormal_response_to2.66330912
16MP0001986_abnormal_taste_sensitivity2.47232424
17MP0002095_abnormal_skin_pigmentation2.40562734
18MP0009379_abnormal_foot_pigmentation2.35740978
19MP0003763_abnormal_thymus_physiology2.24406016
20MP0003806_abnormal_nucleotide_metabolis2.18601415
21* MP0002398_abnormal_bone_marrow2.17016476
22MP0005025_abnormal_response_to2.16288843
23MP0006054_spinal_hemorrhage2.15438963
24MP0000490_abnormal_crypts_of1.98309630
25MP0002736_abnormal_nociception_after1.95916342
26* MP0000689_abnormal_spleen_morphology1.92742075
27MP0001800_abnormal_humoral_immune1.92247436
28MP0003866_abnormal_defecation1.87451865
29MP0005410_abnormal_fertilization1.85778239
30MP0009278_abnormal_bone_marrow1.83922073
31MP0003718_maternal_effect1.83592652
32MP0003943_abnormal_hepatobiliary_system1.83406287
33MP0002420_abnormal_adaptive_immunity1.82151054
34MP0002452_abnormal_antigen_presenting1.81730596
35* MP0002722_abnormal_immune_system1.80201388
36MP0001819_abnormal_immune_cell1.78607414
37* MP0002723_abnormal_immune_serum1.77500302
38MP0003724_increased_susceptibility_to1.77429206
39MP0000230_abnormal_systemic_arterial1.75811938
40MP0008775_abnormal_heart_ventricle1.75381003
41MP0002166_altered_tumor_susceptibility1.72231310
42MP0001853_heart_inflammation1.71452836
43MP0003787_abnormal_imprinting1.70826863
44* MP0000716_abnormal_immune_system1.70470804
45MP0002148_abnormal_hypersensitivity_rea1.68047651
46* MP0002429_abnormal_blood_cell1.65546620
47MP0010155_abnormal_intestine_physiology1.65273378
48MP0010368_abnormal_lymphatic_system1.64632776
49MP0005645_abnormal_hypothalamus_physiol1.64290914
50MP0003303_peritoneal_inflammation1.59849351
51MP0006292_abnormal_olfactory_placode1.58146303
52MP0001968_abnormal_touch/_nociception1.57844618
53MP0001873_stomach_inflammation1.55466084
54MP0001188_hyperpigmentation1.55018924
55MP0008007_abnormal_cellular_replicative1.54142597
56MP0000015_abnormal_ear_pigmentation1.53278329
57MP0003436_decreased_susceptibility_to1.50295946
58MP0008872_abnormal_physiological_respon1.48263457
59MP0005000_abnormal_immune_tolerance1.46968014
60MP0005165_increased_susceptibility_to1.46848229
61MP0000383_abnormal_hair_follicle1.46842471
62MP0010094_abnormal_chromosome_stability1.43809886
63MP0009697_abnormal_copulation1.42378936
64MP0000703_abnormal_thymus_morphology1.41627673
65MP0005409_darkened_coat_color1.39398399
66MP0002419_abnormal_innate_immunity1.38986778
67MP0005083_abnormal_biliary_tract1.35579492
68MP0004084_abnormal_cardiac_muscle1.33755118
69MP0001790_abnormal_immune_system1.31599122
70MP0005387_immune_system_phenotype1.31599122
71MP0008058_abnormal_DNA_repair1.30468308
72MP0002733_abnormal_thermal_nociception1.29669648
73MP0003868_abnormal_feces_composition1.25000983
74MP0003011_delayed_dark_adaptation1.23688689
75MP0002006_tumorigenesis1.18666184
76MP0003191_abnormal_cellular_cholesterol1.15983306
77MP0003656_abnormal_erythrocyte_physiolo1.15874010
78MP0006276_abnormal_autonomic_nervous1.14315461
79MP0008057_abnormal_DNA_replication1.13925485
80MP0000681_abnormal_thyroid_gland1.12142768
81MP0003075_altered_response_to1.12031694
82MP0001845_abnormal_inflammatory_respons1.09723680
83MP0001851_eye_inflammation1.09723419
84MP0009333_abnormal_splenocyte_physiolog1.09484628
85MP0004510_myositis1.07012271
86MP0001533_abnormal_skeleton_physiology1.03665974
87MP0002009_preneoplasia1.03515299
88MP0004484_altered_response_of1.02905746
89MP0002075_abnormal_coat/hair_pigmentati1.02508549
90MP0001348_abnormal_lacrimal_gland1.01332540
91MP0006036_abnormal_mitochondrial_physio1.01098874
92MP0002405_respiratory_system_inflammati1.00677058
93MP0003172_abnormal_lysosome_physiology0.99171244
94MP0000313_abnormal_cell_death0.98709329
95MP0001664_abnormal_digestion0.98305166
96MP0002019_abnormal_tumor_incidence0.97748462
97MP0002138_abnormal_hepatobiliary_system0.97589350
98MP0002089_abnormal_postnatal_growth/wei0.96944746
99MP0002132_abnormal_respiratory_system0.95321639
100MP0008875_abnormal_xenobiotic_pharmacok0.95142454
101MP0001663_abnormal_digestive_system0.94887542
102MP0002735_abnormal_chemical_nociception0.94442490
103* MP0008469_abnormal_protein_level0.92724644
104MP0006035_abnormal_mitochondrial_morpho0.90529759
105MP0001879_abnormal_lymphatic_vessel0.90353740
106MP0002938_white_spotting0.90104632
107MP0001765_abnormal_ion_homeostasis0.89665968
108MP0003567_abnormal_fetal_cardiomyocyte0.89473114
109MP0003077_abnormal_cell_cycle0.87080918
110* MP0009642_abnormal_blood_homeostasis0.86146259
111MP0003828_pulmonary_edema0.85902350
112MP0005670_abnormal_white_adipose0.84865395
113MP0002877_abnormal_melanocyte_morpholog0.84194083
114MP0005535_abnormal_body_temperature0.83009925
115MP0005167_abnormal_blood-brain_barrier0.82764988
116MP0010386_abnormal_urinary_bladder0.81991821
117MP0004036_abnormal_muscle_relaxation0.81482850
118MP0003786_premature_aging0.80280799
119MP0009765_abnormal_xenobiotic_induced0.80157216
120MP0003693_abnormal_embryo_hatching0.80114375
121MP0004957_abnormal_blastocyst_morpholog0.79831758
122MP0002234_abnormal_pharynx_morphology0.78350505
123MP0001764_abnormal_homeostasis0.76583105
124MP0005058_abnormal_lysosome_morphology0.76254136
125MP0004130_abnormal_muscle_cell0.76066467
126MP0004947_skin_inflammation0.75935126
127MP0000249_abnormal_blood_vessel0.75143264
128MP0001970_abnormal_pain_threshold0.74147058
129MP0000372_irregular_coat_pigmentation0.72824215
130MP0009764_decreased_sensitivity_to0.71370309
131MP0003252_abnormal_bile_duct0.71091473
132MP0003186_abnormal_redox_activity0.70772124
133MP0005636_abnormal_mineral_homeostasis0.70196585
134MP0000477_abnormal_intestine_morphology0.69096712
135MP0001905_abnormal_dopamine_level0.68640534
136MP0000598_abnormal_liver_morphology0.68268355
137MP0010329_abnormal_lipoprotein_level0.67451590
138MP0006082_CNS_inflammation0.67283238
139MP0005084_abnormal_gallbladder_morpholo0.67129187
140MP0003300_gastrointestinal_ulcer0.66749439
141MP0008874_decreased_physiological_sensi0.66717200
142MP0003638_abnormal_response/metabolism_0.63502525
143MP0003315_abnormal_perineum_morphology0.63158441
144MP0002933_joint_inflammation0.62451924
145MP0008995_early_reproductive_senescence0.62178377
146MP0009763_increased_sensitivity_to0.60433813
147MP0000343_altered_response_to0.57859064
148MP0005310_abnormal_salivary_gland0.51809346

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)7.29941125
2Aplastic anemia (HP:0001915)6.24505907
3Prolonged bleeding time (HP:0003010)5.64200153
4Abnormality of cells of the erythroid lineage (HP:0012130)4.81817299
5Abnormal number of erythroid precursors (HP:0012131)4.72244385
6* Gingival bleeding (HP:0000225)4.40620773
7Myositis (HP:0100614)4.25689914
8Petechiae (HP:0000967)4.21038221
9IgM deficiency (HP:0002850)4.09744724
10Type 2 muscle fiber atrophy (HP:0003554)3.99727481
11Muscle fiber atrophy (HP:0100295)3.94621490
12Chronic otitis media (HP:0000389)3.86782282
13Dyschromatopsia (HP:0007641)3.84079091
14Reticulocytopenia (HP:0001896)3.73319774
15* Epistaxis (HP:0000421)3.63770831
16Type I transferrin isoform profile (HP:0003642)3.41007215
17Abnormal platelet function (HP:0011869)3.39069792
18Impaired platelet aggregation (HP:0003540)3.39069792
19Reduced antithrombin III activity (HP:0001976)3.38499854
20Acute myeloid leukemia (HP:0004808)3.38440130
21Elevated erythrocyte sedimentation rate (HP:0003565)3.34421578
22Pallor (HP:0000980)3.33748842
23* Thrombocytosis (HP:0001894)3.25803729
24Poikilocytosis (HP:0004447)3.20910303
25Autoimmune hemolytic anemia (HP:0001890)3.20889344
26Purpura (HP:0000979)3.19423376
27Renal Fanconi syndrome (HP:0001994)2.99424847
28Hyperlipoproteinemia (HP:0010980)2.98908614
29Fatigue (HP:0012378)2.97163482
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.92088288
31Decreased central vision (HP:0007663)2.90392334
32Gonadotropin excess (HP:0000837)2.87082064
33Hyperthyroidism (HP:0000836)2.84545825
34Spontaneous hematomas (HP:0007420)2.80161995
35Hyperglycinemia (HP:0002154)2.79323115
36Asplenia (HP:0001746)2.78312921
37Abnormality of transition element cation homeostasis (HP:0011030)2.76581096
38Recurrent bronchitis (HP:0002837)2.75907321
39Paralysis (HP:0003470)2.75387644
40Hypothermia (HP:0002045)2.73883476
41Abnormality of the nasal mucosa (HP:0000433)2.72332134
42Syringomyelia (HP:0003396)2.69451282
43Spinal cord lesions (HP:0100561)2.69451282
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.68350953
45Abnormal protein N-linked glycosylation (HP:0012347)2.68350953
46Abnormal protein glycosylation (HP:0012346)2.68350953
47Abnormal glycosylation (HP:0012345)2.68350953
48Stomatitis (HP:0010280)2.67876558
49Acanthocytosis (HP:0001927)2.66538379
50Nonprogressive disorder (HP:0003680)2.66347368
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.65841737
52Macrocytic anemia (HP:0001972)2.64170170
53Microcytic anemia (HP:0001935)2.60744805
54Abnormality of iron homeostasis (HP:0011031)2.60611117
55Abnormality of T cell physiology (HP:0011840)2.54341557
56Panhypogammaglobulinemia (HP:0003139)2.53952630
57Abnormal pupillary function (HP:0007686)2.53562649
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.52800127
59Lip pit (HP:0100267)2.50218559
60Albinism (HP:0001022)2.49702629
61Acute lymphatic leukemia (HP:0006721)2.48609453
62* Abnormality of the heme biosynthetic pathway (HP:0010472)2.47508273
63Erythema (HP:0010783)2.46037342
64Aplasia/Hypoplasia of the spleen (HP:0010451)2.44521297
65Abolished electroretinogram (ERG) (HP:0000550)2.43666833
66Beaking of vertebral bodies (HP:0004568)2.38288369
67Menorrhagia (HP:0000132)2.36997820
68IgG deficiency (HP:0004315)2.36346666
69Obstructive lung disease (HP:0006536)2.35554222
70Chronic obstructive pulmonary disease (HP:0006510)2.35554222
71Colon cancer (HP:0003003)2.34054746
72Recurrent viral infections (HP:0004429)2.33825802
73Depressed nasal tip (HP:0000437)2.33393858
7411 pairs of ribs (HP:0000878)2.33250320
75Abnormality of the columella (HP:0009929)2.32499355
76Hepatosplenomegaly (HP:0001433)2.32333420
77Patchy hypopigmentation of hair (HP:0011365)2.31128434
78Abnormality of the prostate (HP:0008775)2.28329040
79Agammaglobulinemia (HP:0004432)2.27231450
80* Myelodysplasia (HP:0002863)2.26722141
81Hypoproteinemia (HP:0003075)2.24619130
82Generalized aminoaciduria (HP:0002909)2.22103856
83Hyperglycinuria (HP:0003108)2.22029326
84Cellulitis (HP:0100658)2.21955310
85Orchitis (HP:0100796)2.19760812
86Weak cry (HP:0001612)2.17959320
87Increased cerebral lipofuscin (HP:0011813)2.17346705
88Lymphoma (HP:0002665)2.16241042
89Abnormality of B cell number (HP:0010975)2.14778305
90B lymphocytopenia (HP:0010976)2.14778305
91Central scotoma (HP:0000603)2.14578345
92Renal cortical cysts (HP:0000803)2.13863648
93Neutropenia (HP:0001875)2.12016020
94Microretrognathia (HP:0000308)2.11702431
95Increased IgM level (HP:0003496)2.11344581
96Stomach cancer (HP:0012126)2.10464664
97Acute hepatic failure (HP:0006554)2.08828515
98Abnormal platelet volume (HP:0011876)2.08524165
99Increased muscle lipid content (HP:0009058)2.05566403
100Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05325328
101Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05325328
102Exertional dyspnea (HP:0002875)2.04491983
103* Pancytopenia (HP:0001876)2.02359235
104Encephalitis (HP:0002383)2.02142992
105Abnormality of T cells (HP:0002843)2.02024752
106Abnormality of male internal genitalia (HP:0000022)2.01309935
107Insulin-resistant diabetes mellitus (HP:0000831)2.01107654
108Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00663574
109Poikiloderma (HP:0001029)1.98209433
110Gastrointestinal inflammation (HP:0004386)1.97184056
111Increased serum ferritin (HP:0003281)1.96775813
112Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95887488
113Granulocytopenia (HP:0001913)1.95147811
114Posterior subcapsular cataract (HP:0007787)1.94829633
115Recurrent bacterial skin infections (HP:0005406)1.94592304
116Abnormal auditory evoked potentials (HP:0006958)1.94534911
117Recurrent abscess formation (HP:0002722)1.94516044
118Hepatocellular necrosis (HP:0001404)1.94191142
119Nasal polyposis (HP:0100582)1.94133455
120Neonatal hypoglycemia (HP:0001998)1.93316472
121Thyroid-stimulating hormone excess (HP:0002925)1.92612763
122Gastrointestinal stroma tumor (HP:0100723)1.92053255
123Microvesicular hepatic steatosis (HP:0001414)1.91977801
124Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91259310
125Easy fatigability (HP:0003388)1.90213244
126Hypoplasia of the thymus (HP:0000778)1.89833073
127Lymphopenia (HP:0001888)1.89816786
128White forelock (HP:0002211)1.89449504
129Abnormality of the renal cortex (HP:0011035)1.89154606
130Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88295254
131Birth length less than 3rd percentile (HP:0003561)1.88114682
1323-Methylglutaconic aciduria (HP:0003535)1.87597216
133Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86803251
134Dicarboxylic aciduria (HP:0003215)1.86803251
135Cerebral palsy (HP:0100021)1.85587751
136Optic neuritis (HP:0100653)1.85316104
137Retrobulbar optic neuritis (HP:0100654)1.85316104
138Abnormality of glycine metabolism (HP:0010895)1.84296042
139Abnormality of serine family amino acid metabolism (HP:0010894)1.84296042
140Ileus (HP:0002595)1.82884520
141Increased intramyocellular lipid droplets (HP:0012240)1.82539404
142Facial diplegia (HP:0001349)1.81680910
143Hyperpituitarism (HP:0010514)1.81013410
144Inflammation of the large intestine (HP:0002037)1.80392044
145Abnormality of the common coagulation pathway (HP:0010990)1.78832334
146Meningitis (HP:0001287)1.78227107
147Recurrent skin infections (HP:0001581)1.78223876
148* Bruising susceptibility (HP:0000978)1.77992606
149Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.77868314
150Bone marrow hypocellularity (HP:0005528)1.77372253
151Visual hallucinations (HP:0002367)1.76310289
152Episodic fever (HP:0001954)1.76165268
153Attenuation of retinal blood vessels (HP:0007843)1.75271027
154Hypertensive crisis (HP:0100735)1.74980108
155Hepatic necrosis (HP:0002605)1.73467901
156Joint swelling (HP:0001386)1.72246639
157Abnormality of renal resorption (HP:0011038)1.66069355
158Enlarged kidneys (HP:0000105)1.65023422
159Eosinophilia (HP:0001880)1.64775118
160Seborrheic dermatitis (HP:0001051)1.64552312
161Congenital stationary night blindness (HP:0007642)1.60053966
162Nausea (HP:0002018)1.59311573
163Abnormality of lateral ventricle (HP:0030047)1.56902677
164Leukocytosis (HP:0001974)1.56579765
165Abnormality of fatty-acid metabolism (HP:0004359)1.56080706
166Joint hemorrhage (HP:0005261)1.56077350
167Autoimmune thrombocytopenia (HP:0001973)1.55380505
168Mitochondrial inheritance (HP:0001427)1.55311955
169Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.55207764
170Brushfield spots (HP:0001088)1.54555456
171Abnormal drinking behavior (HP:0030082)1.54434063

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR13.39169671
2TIE13.34305295
3KIT3.16681186
4NME23.12925300
5STK163.09661645
6TNIK3.00315786
7WEE12.81833484
8MST42.77006879
9MUSK2.73038241
10MAP4K12.63811682
11MAP2K32.62399145
12CDK192.51129925
13RIPK42.44655634
14ZAK2.39734479
15BTK2.30464326
16FLT32.29986147
17JAK32.28156812
18TGFBR22.27085280
19NUAK12.24818389
20EEF2K2.09637744
21TEC2.07188222
22MATK1.99059457
23BRSK21.95443554
24ACVR1B1.92936116
25BMX1.90765871
26ITK1.88526930
27MKNK11.83185004
28TLK11.82715438
29MAPKAPK51.77942886
30CSF1R1.77935528
31RPS6KB21.74982705
32SCYL21.61341467
33BCKDK1.59822386
34TXK1.58119338
35MAP3K121.55959000
36GRK61.49584622
37ZAP701.47970854
38PTK2B1.41320294
39VRK11.40371530
40MAP2K61.37725716
41MAP4K21.31364991
42SYK1.30746657
43CAMKK21.29983252
44DAPK21.29971612
45PIM21.28409464
46PASK1.25332435
47CDK81.24959425
48EIF2AK11.24331832
49CCNB11.19904485
50TBK11.17991410
51IKBKE1.17375932
52ADRBK21.16170621
53GRK51.16063839
54IKBKB1.10827390
55TNK21.08094729
56TESK20.97448894
57PRKCQ0.96772960
58NLK0.95609876
59FES0.93791760
60CAMK10.91964218
61MAPKAPK30.91144793
62BMPR20.90634311
63LCK0.89380532
64PRKG20.88356265
65MAP3K130.83919200
66MAP3K60.83261619
67PIK3CG0.82815544
68LYN0.81383158
69STK40.80624010
70MAP3K70.79719671
71MAP3K140.79255805
72MKNK20.79131750
73ADRBK10.79065918
74BLK0.79044705
75MYLK0.76749836
76DYRK30.74752288
77IRAK40.71908994
78MAP2K70.71580999
79MAP3K50.71521967
80VRK20.70106448
81GRK10.68974988
82PKN20.68356348
83HIPK20.68097930
84KDR0.66956542
85DAPK30.66694963
86FRK0.65682963
87TYK20.65139219
88DAPK10.64340623
89PLK20.61451526
90FER0.61040412
91BRSK10.60765564
92RAF10.58935268
93LRRK20.58220009
94ATR0.57654855
95CDC70.56674339
96PAK10.54567042
97CDK70.54218544
98PIM10.54096248
99CDK90.53451925
100JAK20.52663595
101IRAK10.51933634
102MAP3K10.51898537
103MAPK40.51333610
104RIPK10.50707195
105MAPK110.50538948
106HCK0.50402092
107PRKCD0.49638823
108PBK0.49098987
109IGF1R0.48393267
110BMPR1B0.47438926
111PDK10.45360606
112CHUK0.45167892
113TRPM70.45097207
114PKN10.43082006
115CLK10.42983734
116STK30.42766038
117PHKG20.42717486
118PHKG10.42717486
119ABL10.42412199
120PRKCA0.42150976
121RPS6KA60.41097074
122RPS6KA50.40413425
123PRKD10.39911486
124SIK30.39623255
125TAOK30.38736165
126FGR0.38666586
127PINK10.37861903
128ARAF0.36170604
129PIK3CA0.35873926
130MAP3K110.35804191
131MAP3K30.34539138
132TAOK20.34538153
133ABL20.34445275
134WNK40.34154173
135MAPK30.33936010
136CSNK1G30.33905205
137MAPK130.30052644
138INSRR0.29963626
139PAK40.29134674
140PRKACG0.28824921
141MOS0.28519493
142ERN10.27886346
143CDK40.25773479
144IRAK30.24762985
145SRPK10.24705922
146RPS6KC10.24196012
147RPS6KL10.24196012
148SRC0.23756272
149GRK70.23183662
150MAPK150.22471009
151CSNK2A20.22439910
152NEK20.22082963

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.36940054
2DNA replication_Homo sapiens_hsa030304.46719419
3Mismatch repair_Homo sapiens_hsa034303.64595966
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.79176143
5Base excision repair_Homo sapiens_hsa034102.71779609
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.71205748
7Graft-versus-host disease_Homo sapiens_hsa053322.65474191
8Autoimmune thyroid disease_Homo sapiens_hsa053202.58061666
9Nucleotide excision repair_Homo sapiens_hsa034202.37527507
10Pyrimidine metabolism_Homo sapiens_hsa002402.33579365
11Type I diabetes mellitus_Homo sapiens_hsa049402.33527283
12Systemic lupus erythematosus_Homo sapiens_hsa053222.30058613
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.26424097
14Homologous recombination_Homo sapiens_hsa034402.19530907
15RNA polymerase_Homo sapiens_hsa030202.08416118
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.95071010
17Primary immunodeficiency_Homo sapiens_hsa053401.88392336
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.77893328
19Platelet activation_Homo sapiens_hsa046111.75503272
20Spliceosome_Homo sapiens_hsa030401.74799717
21Staphylococcus aureus infection_Homo sapiens_hsa051501.72855421
22Herpes simplex infection_Homo sapiens_hsa051681.69347163
23Nitrogen metabolism_Homo sapiens_hsa009101.66906349
24RNA degradation_Homo sapiens_hsa030181.64953528
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62749828
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62062752
27B cell receptor signaling pathway_Homo sapiens_hsa046621.58634801
28Measles_Homo sapiens_hsa051621.55887494
29Leishmaniasis_Homo sapiens_hsa051401.51225023
30Folate biosynthesis_Homo sapiens_hsa007901.51064253
31Olfactory transduction_Homo sapiens_hsa047401.43645080
32Purine metabolism_Homo sapiens_hsa002301.38756369
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.38159181
34Hematopoietic cell lineage_Homo sapiens_hsa046401.37671209
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37312333
36Caffeine metabolism_Homo sapiens_hsa002321.32959017
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.28101315
38* Jak-STAT signaling pathway_Homo sapiens_hsa046301.24831972
39Linoleic acid metabolism_Homo sapiens_hsa005911.24554503
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.23451378
41Non-homologous end-joining_Homo sapiens_hsa034501.19670018
42Rheumatoid arthritis_Homo sapiens_hsa053231.19091433
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14655485
44Acute myeloid leukemia_Homo sapiens_hsa052211.14584606
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14055207
46Sulfur relay system_Homo sapiens_hsa041221.13045010
47Basal transcription factors_Homo sapiens_hsa030221.12263654
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.11121881
49Glutathione metabolism_Homo sapiens_hsa004801.09022925
50Cell cycle_Homo sapiens_hsa041101.08958075
51Shigellosis_Homo sapiens_hsa051311.08153846
52N-Glycan biosynthesis_Homo sapiens_hsa005101.07890680
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04693902
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03856926
55Glycerolipid metabolism_Homo sapiens_hsa005611.02226906
56Antigen processing and presentation_Homo sapiens_hsa046121.01833024
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01528493
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98072087
59Peroxisome_Homo sapiens_hsa041460.97697308
60Chemical carcinogenesis_Homo sapiens_hsa052040.97632070
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97514231
62Alcoholism_Homo sapiens_hsa050340.95215741
63Viral myocarditis_Homo sapiens_hsa054160.94671627
64Thyroid cancer_Homo sapiens_hsa052160.94370838
65Serotonergic synapse_Homo sapiens_hsa047260.93739905
66RNA transport_Homo sapiens_hsa030130.91962215
67Fanconi anemia pathway_Homo sapiens_hsa034600.90477561
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88674534
69Influenza A_Homo sapiens_hsa051640.88250898
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.85225570
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84886114
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84436712
73Protein export_Homo sapiens_hsa030600.84258974
74Hepatitis B_Homo sapiens_hsa051610.81799356
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.79840969
76Legionellosis_Homo sapiens_hsa051340.79275575
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.78076463
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77921499
79Other glycan degradation_Homo sapiens_hsa005110.77381502
80ECM-receptor interaction_Homo sapiens_hsa045120.76834328
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.76176955
82Renin secretion_Homo sapiens_hsa049240.75965849
83* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75065217
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72648692
85Proteasome_Homo sapiens_hsa030500.71765830
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71549924
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70936771
88Allograft rejection_Homo sapiens_hsa053300.70818120
89Ovarian steroidogenesis_Homo sapiens_hsa049130.69781751
90Osteoclast differentiation_Homo sapiens_hsa043800.69368339
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69282800
92Phototransduction_Homo sapiens_hsa047440.69205134
93Epstein-Barr virus infection_Homo sapiens_hsa051690.67413528
94Arachidonic acid metabolism_Homo sapiens_hsa005900.67387011
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65225307
96Salivary secretion_Homo sapiens_hsa049700.64349921
97Galactose metabolism_Homo sapiens_hsa000520.63751216
98p53 signaling pathway_Homo sapiens_hsa041150.63240799
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61333610
100Malaria_Homo sapiens_hsa051440.59784442
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59429189
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59006234
103Pentose phosphate pathway_Homo sapiens_hsa000300.58613568
104Pertussis_Homo sapiens_hsa051330.57762774
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56531340
106Pancreatic secretion_Homo sapiens_hsa049720.55542832
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54316664
108Calcium signaling pathway_Homo sapiens_hsa040200.54017971
109Butanoate metabolism_Homo sapiens_hsa006500.53905307
110African trypanosomiasis_Homo sapiens_hsa051430.53071377
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52818114
112TNF signaling pathway_Homo sapiens_hsa046680.50231625
113Apoptosis_Homo sapiens_hsa042100.49656719
114Toxoplasmosis_Homo sapiens_hsa051450.46211997
115Prolactin signaling pathway_Homo sapiens_hsa049170.45692463
116Hepatitis C_Homo sapiens_hsa051600.45299151
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45184803
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44605029
119Asthma_Homo sapiens_hsa053100.44138433
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43172605
121Circadian entrainment_Homo sapiens_hsa047130.42212117
122Fatty acid elongation_Homo sapiens_hsa000620.41355098
123Salmonella infection_Homo sapiens_hsa051320.40015680
124Tyrosine metabolism_Homo sapiens_hsa003500.39738907
125Parkinsons disease_Homo sapiens_hsa050120.38952893
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.38446029
127HTLV-I infection_Homo sapiens_hsa051660.37120529
128ABC transporters_Homo sapiens_hsa020100.36247654
129Long-term depression_Homo sapiens_hsa047300.36047855
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.35018379
131Phagosome_Homo sapiens_hsa041450.34332071
132Collecting duct acid secretion_Homo sapiens_hsa049660.34000269
133Chronic myeloid leukemia_Homo sapiens_hsa052200.33345024
134Regulation of autophagy_Homo sapiens_hsa041400.31514803
135Fructose and mannose metabolism_Homo sapiens_hsa000510.31341946
136Tuberculosis_Homo sapiens_hsa051520.30912126
137Non-small cell lung cancer_Homo sapiens_hsa052230.29114310
138Retinol metabolism_Homo sapiens_hsa008300.29053878
139Viral carcinogenesis_Homo sapiens_hsa052030.28831814
140Notch signaling pathway_Homo sapiens_hsa043300.28008751
141Endocytosis_Homo sapiens_hsa041440.26976184
142Metabolic pathways_Homo sapiens_hsa011000.26846713
143Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26372194
144Vitamin digestion and absorption_Homo sapiens_hsa049770.25231625
145One carbon pool by folate_Homo sapiens_hsa006700.24931402
146AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.22469270
147Chemokine signaling pathway_Homo sapiens_hsa040620.22442054
148HIF-1 signaling pathway_Homo sapiens_hsa040660.22112621
149Selenocompound metabolism_Homo sapiens_hsa004500.20640644
150Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20385422
151T cell receptor signaling pathway_Homo sapiens_hsa046600.19183296

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