MPND

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.48875742
2L-phenylalanine metabolic process (GO:0006558)6.48875742
3L-phenylalanine catabolic process (GO:0006559)6.37189405
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.37189405
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.50852864
6aromatic amino acid family catabolic process (GO:0009074)5.48404558
7kynurenine metabolic process (GO:0070189)5.39866265
8alpha-linolenic acid metabolic process (GO:0036109)5.26087247
9glyoxylate metabolic process (GO:0046487)5.18152949
10sulfur amino acid catabolic process (GO:0000098)4.97490201
11urea metabolic process (GO:0019627)4.86532311
12urea cycle (GO:0000050)4.86532311
13tryptophan catabolic process (GO:0006569)4.74272129
14indole-containing compound catabolic process (GO:0042436)4.74272129
15indolalkylamine catabolic process (GO:0046218)4.74272129
16negative regulation of fibrinolysis (GO:0051918)4.70181842
17bile acid biosynthetic process (GO:0006699)4.67653269
18high-density lipoprotein particle remodeling (GO:0034375)4.51015615
19nitrogen cycle metabolic process (GO:0071941)4.45448101
20serine family amino acid catabolic process (GO:0009071)4.40673384
21complement activation, alternative pathway (GO:0006957)4.38382408
22tryptophan metabolic process (GO:0006568)4.38075418
23negative regulation of cholesterol transport (GO:0032375)4.34322155
24negative regulation of sterol transport (GO:0032372)4.34322155
25lysine metabolic process (GO:0006553)4.29923052
26lysine catabolic process (GO:0006554)4.29923052
27negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.29642221
28regulation of fibrinolysis (GO:0051917)4.29351386
29regulation of protein activation cascade (GO:2000257)4.29180900
30glycine metabolic process (GO:0006544)4.28627005
31cysteine metabolic process (GO:0006534)4.24097143
32amyloid precursor protein catabolic process (GO:0042987)4.17071922
33viral transcription (GO:0019083)4.17041975
34protein carboxylation (GO:0018214)4.14298381
35peptidyl-glutamic acid carboxylation (GO:0017187)4.14298381
36dicarboxylic acid biosynthetic process (GO:0043650)4.13799594
37pyrimidine nucleobase catabolic process (GO:0006208)4.09439134
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.08099233
39cellular ketone body metabolic process (GO:0046950)4.07380031
40glycosphingolipid catabolic process (GO:0046479)4.06024021
41ethanol oxidation (GO:0006069)4.04484507
42glutamate metabolic process (GO:0006536)4.03770657
43alpha-amino acid catabolic process (GO:1901606)4.00496339
44regulation of complement activation (GO:0030449)3.99819765
45regulation of triglyceride catabolic process (GO:0010896)3.97213506
46arginine metabolic process (GO:0006525)3.94248592
47aromatic amino acid family metabolic process (GO:0009072)3.93934841
48cellular modified amino acid catabolic process (GO:0042219)3.93434445
49bile acid metabolic process (GO:0008206)3.87465324
50regulation of cholesterol homeostasis (GO:2000188)3.85469583
51reverse cholesterol transport (GO:0043691)3.85088440
52negative regulation of erythrocyte differentiation (GO:0045647)3.84384977
532-oxoglutarate metabolic process (GO:0006103)3.83886113
54homocysteine metabolic process (GO:0050667)3.83793447
55regulation of cholesterol esterification (GO:0010872)3.82303205
56cellular amino acid catabolic process (GO:0009063)3.79041396
57plasma lipoprotein particle remodeling (GO:0034369)3.78853926
58protein-lipid complex remodeling (GO:0034368)3.78853926
59macromolecular complex remodeling (GO:0034367)3.78853926
60triglyceride homeostasis (GO:0070328)3.76086348
61acylglycerol homeostasis (GO:0055090)3.76086348
62coenzyme catabolic process (GO:0009109)3.75609421
63ribosomal small subunit biogenesis (GO:0042274)3.75254789
64response to peptidoglycan (GO:0032494)3.73586735
65plasma lipoprotein particle clearance (GO:0034381)3.73056013
66tyrosine metabolic process (GO:0006570)3.72651050
67positive regulation of fatty acid beta-oxidation (GO:0032000)3.66179822
68regulation of fatty acid beta-oxidation (GO:0031998)3.65847131
69serine family amino acid metabolic process (GO:0009069)3.65203514
70cell-cell junction maintenance (GO:0045217)3.64566161
71translational termination (GO:0006415)3.63981147
72acetyl-CoA metabolic process (GO:0006084)3.63815210
73nucleobase catabolic process (GO:0046113)3.60071176
74glycolipid catabolic process (GO:0019377)3.59382538
75aspartate family amino acid catabolic process (GO:0009068)3.57436250
76phospholipid efflux (GO:0033700)3.56474743
77ketone body metabolic process (GO:1902224)3.52596125
78drug catabolic process (GO:0042737)3.50901205
79positive regulation of lipid catabolic process (GO:0050996)3.46883996
80amino-acid betaine metabolic process (GO:0006577)3.45806979
81aldehyde catabolic process (GO:0046185)3.45366316
82benzene-containing compound metabolic process (GO:0042537)3.39864331
83short-chain fatty acid metabolic process (GO:0046459)3.38714932
84drug metabolic process (GO:0017144)3.36658367
85macrophage activation involved in immune response (GO:0002281)3.36585188
86modulation by symbiont of host defense response (GO:0052031)3.36012507
87modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.36012507
88modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.36012507
89positive regulation by organism of defense response of other organism involved in symbiotic interact3.36012507
90modulation by symbiont of host immune response (GO:0052553)3.36012507
91positive regulation by symbiont of host defense response (GO:0052509)3.36012507
92cholesterol efflux (GO:0033344)3.32670295
93mannose metabolic process (GO:0006013)3.25919697
94negative regulation of granulocyte differentiation (GO:0030853)3.25906626
95negative regulation of interleukin-12 production (GO:0032695)3.25329075
96bile acid and bile salt transport (GO:0015721)3.24874239
97carboxylic acid catabolic process (GO:0046395)3.24051334
98organic acid catabolic process (GO:0016054)3.24051334
99ethanol metabolic process (GO:0006067)3.22071761
100response to acidic pH (GO:0010447)3.21167349
101serine family amino acid biosynthetic process (GO:0009070)3.21064616
102pentose metabolic process (GO:0019321)3.19711120
103intestinal cholesterol absorption (GO:0030299)3.18892804
104indolalkylamine metabolic process (GO:0006586)3.18440502
105imidazole-containing compound metabolic process (GO:0052803)3.18232646
106flavonoid metabolic process (GO:0009812)3.17698638
107positive regulation of fatty acid oxidation (GO:0046321)3.16133600
108exogenous drug catabolic process (GO:0042738)3.13604010
109ceramide catabolic process (GO:0046514)3.13349493
110glutamine family amino acid biosynthetic process (GO:0009084)3.12140646
111positive regulation of T cell apoptotic process (GO:0070234)3.11976042
112arginine catabolic process (GO:0006527)3.11656025
113fibrinolysis (GO:0042730)3.10918183
114negative regulation of cell size (GO:0045792)3.10783317
115positive regulation of lipoprotein lipase activity (GO:0051006)3.10391528
116positive regulation of triglyceride lipase activity (GO:0061365)3.10391528
117GDP-mannose metabolic process (GO:0019673)3.10156867
118cytolysis (GO:0019835)3.09970534
119NIK/NF-kappaB signaling (GO:0038061)3.08028951
120monocarboxylic acid catabolic process (GO:0072329)3.08006438
121viral life cycle (GO:0019058)3.07707395
122positive regulation of lymphocyte apoptotic process (GO:0070230)3.07412858
123positive regulation of triglyceride metabolic process (GO:0090208)3.07201101
124translational elongation (GO:0006414)3.06314063
125modulation by symbiont of host cellular process (GO:0044068)3.05835012
126amino sugar catabolic process (GO:0046348)3.05523668
127regulation of cholesterol storage (GO:0010885)3.02405436
128oxaloacetate metabolic process (GO:0006107)3.02391406
129plasma lipoprotein particle assembly (GO:0034377)3.01606341
130cholesterol homeostasis (GO:0042632)3.00836551
131acute-phase response (GO:0006953)3.00701062
132complement activation, classical pathway (GO:0006958)2.99291320
133dicarboxylic acid catabolic process (GO:0043649)2.98446051
134sterol homeostasis (GO:0055092)2.96446606
135mitochondrion transport along microtubule (GO:0047497)2.94534484
136establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.94534484
137modulation by virus of host process (GO:0019054)2.91405610
138sphingolipid catabolic process (GO:0030149)2.85118820
139oligosaccharide catabolic process (GO:0009313)2.84370615
140purine deoxyribonucleotide catabolic process (GO:0009155)2.83857491
141regulation of monocyte differentiation (GO:0045655)2.82877641
142fat-soluble vitamin biosynthetic process (GO:0042362)2.81126863
143virion attachment to host cell (GO:0019062)2.80091337
144adhesion of symbiont to host cell (GO:0044650)2.80091337
145barbed-end actin filament capping (GO:0051016)2.79588379
146neutrophil activation involved in immune response (GO:0002283)2.78630120
147lipopolysaccharide-mediated signaling pathway (GO:0031663)2.75909602
148nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.73965699
149activation of MAPKKK activity (GO:0000185)2.73720942
150cellular protein complex disassembly (GO:0043624)2.73635891
151glucose 6-phosphate metabolic process (GO:0051156)2.72649456
152membrane lipid catabolic process (GO:0046466)2.71975637
153myeloid dendritic cell differentiation (GO:0043011)2.71964790
154creatine metabolic process (GO:0006600)2.69809196
155positive regulation of Cdc42 GTPase activity (GO:0043089)2.68747017
156protein insertion into membrane (GO:0051205)2.63788161
157cellular response to thyroid hormone stimulus (GO:0097067)2.63668581
158regulation of interferon-beta biosynthetic process (GO:0045357)2.63616779
159protein targeting to ER (GO:0045047)2.62686924
160adhesion of symbiont to host (GO:0044406)2.61975335
161negative regulation of myeloid cell apoptotic process (GO:0033033)2.61875708
162amyloid precursor protein metabolic process (GO:0042982)2.60974612
163SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.60645418
164regulation of early endosome to late endosome transport (GO:2000641)2.60513157
165immunoglobulin mediated immune response (GO:0016064)2.60456794
166positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.60204692
167cell junction maintenance (GO:0034331)2.59570075
168adenosine receptor signaling pathway (GO:0001973)2.56972130
169hydrogen peroxide biosynthetic process (GO:0050665)2.54703471
170protein localization to endoplasmic reticulum (GO:0070972)2.53208183
171establishment of mitochondrion localization (GO:0051654)2.51682455
172cotranslational protein targeting to membrane (GO:0006613)2.50051307
173cellular response to pH (GO:0071467)2.49845057
174N-acetylneuraminate metabolic process (GO:0006054)2.49046132
175detection of bacterium (GO:0016045)2.48861659
176detection of other organism (GO:0098543)2.47862416
177regulation of mononuclear cell migration (GO:0071675)2.46514027
178tooth mineralization (GO:0034505)2.46243003
179protein complex disassembly (GO:0043241)2.45306276
180establishment of protein localization to endoplasmic reticulum (GO:0072599)2.43014935
181lipoxygenase pathway (GO:0019372)2.42743377
182negative regulation of macroautophagy (GO:0016242)2.41291079
183cellular response to virus (GO:0098586)2.37291724
184apoptotic process involved in morphogenesis (GO:0060561)2.36681343
185protein retention in ER lumen (GO:0006621)2.35640368
186respiratory system process (GO:0003016)2.32281870
187response to muramyl dipeptide (GO:0032495)2.31734235
188regulation of mast cell degranulation (GO:0043304)2.31263736
189positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.31200980
190hormone catabolic process (GO:0042447)2.29871299
191monocyte chemotaxis (GO:0002548)2.28670903
192positive regulation of triglyceride biosynthetic process (GO:0010867)2.28306822
193negative regulation of fatty acid biosynthetic process (GO:0045717)2.28268491
194regulation of mammary gland epithelial cell proliferation (GO:0033599)2.27866254
195regulation of superoxide anion generation (GO:0032928)2.27394435
196regulation of leukocyte degranulation (GO:0043300)2.26994948

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.84571668
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.39606727
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.74393812
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.72558463
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.93099812
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.31261525
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.74403212
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.66260870
9LXR_22292898_ChIP-Seq_THP-1_Human2.61641958
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.57081468
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.50904663
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.48760291
13ZNF263_19887448_ChIP-Seq_K562_Human2.36340590
14ZFP281_18757296_ChIP-ChIP_E14_Mouse2.08581453
15ERG_21242973_ChIP-ChIP_JURKAT_Human1.90895628
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85628686
17ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.85131550
18KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82767512
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82233389
20* VDR_24763502_ChIP-Seq_THP-1_Human1.75870366
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75275728
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.71790136
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.71549830
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67398035
25CLOCK_20551151_ChIP-Seq_293T_Human1.66362206
26DNAJC2_21179169_ChIP-ChIP_NT2_Human1.64409217
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63163605
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58951901
29NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.57985507
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.56617000
31RACK7_27058665_Chip-Seq_MCF-7_Human1.56426800
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.56300277
33KDM2B_26808549_Chip-Seq_DND41_Human1.52104592
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48494545
35CREB1_26743006_Chip-Seq_LNCaP_Human1.47445745
36TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.46658110
37* VDR_21846776_ChIP-Seq_THP-1_Human1.46162884
38KDM2B_26808549_Chip-Seq_K562_Human1.45964574
39* MYC_22102868_ChIP-Seq_BL_Human1.44808053
40EZH2_22144423_ChIP-Seq_EOC_Human1.44015622
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.42256142
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41768349
43EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40745648
44* TET1_21451524_ChIP-Seq_MESCs_Mouse1.39694687
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.36481357
46MAF_26560356_Chip-Seq_TH2_Human1.35894803
47* CTCF_26484167_Chip-Seq_Bcells_Mouse1.34279998
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32081623
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.32032802
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31196854
51MAF_26560356_Chip-Seq_TH1_Human1.30596381
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30240774
53SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29530234
54PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29297891
55* P68_20966046_ChIP-Seq_HELA_Human1.26866636
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26706018
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26562076
58CTCF_27219007_Chip-Seq_Bcells_Human1.25143188
59PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23980318
60CTCF_18555785_ChIP-Seq_MESCs_Mouse1.23044143
61* SA1_27219007_Chip-Seq_ERYTHROID_Human1.22884707
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22206366
63* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21824349
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.21215966
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20827152
66* PHF8_20622854_ChIP-Seq_HELA_Human1.19616710
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18770413
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18440285
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17475492
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17162887
71BCL6_27268052_Chip-Seq_Bcells_Human1.16921655
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16053673
73CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15915562
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15862008
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.14874545
76* UTX_26944678_Chip-Seq_JUKART_Human1.14200245
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14036885
78TCF7_22412390_ChIP-Seq_EML_Mouse1.13791102
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13259103
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13221729
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13173475
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12815845
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12582817
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12304897
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.11770487
86BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09715546
87OCT4_18692474_ChIP-Seq_MEFs_Mouse1.09300440
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08863003
89RARA_24833708_ChIP-Seq_LIVER_Mouse1.08807305
90BCOR_27268052_Chip-Seq_Bcells_Human1.08761952
91SMC4_20622854_ChIP-Seq_HELA_Human1.08539830
92BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08462782
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07448311
94CTCF_21964334_Chip-Seq_Bcells_Human1.07140348
95CTCF_20526341_ChIP-Seq_ESCs_Human1.06847399
96SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06369991
97TP53_22127205_ChIP-Seq_IMR90_Human1.05782542
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05513718
99RARB_27405468_Chip-Seq_BRAIN_Mouse1.05319464
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05142216
101SA1_27219007_Chip-Seq_Bcells_Human1.04693955
102RARB_24833708_ChIP-Seq_LIVER_Mouse1.04528025
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04526817
104NCOR1_26117541_ChIP-Seq_K562_Human1.03981207
105JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03455959
106PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03266010
107ELF1_20517297_ChIP-Seq_JURKAT_Human1.02907072
108MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02689583
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02681598
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02443075
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01741607
112STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.01535630
113ESR2_21235772_ChIP-Seq_MCF-7_Human1.01366462
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01243080
115STAT1_20625510_ChIP-Seq_HELA_Human1.00490601
116EZH2_27294783_Chip-Seq_ESCs_Mouse1.00360877
117HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99010552
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98894981
119MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98623424
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95864502
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95242185
122YY1_22570637_ChIP-Seq_MALME-3M_Human0.93876620
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93762798
124TP53_20018659_ChIP-ChIP_R1E_Mouse0.93456308
125RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92349312
126EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92349312
127* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92018515
128SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91950794
129FOXA2_19822575_ChIP-Seq_HepG2_Human0.91563965
130CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89639615
131ATF3_27146783_Chip-Seq_COLON_Human0.88772017
132SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87331812
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87311248
134E2F1_20622854_ChIP-Seq_HELA_Human0.87250861
135FOXP1_21924763_ChIP-Seq_HESCs_Human0.86917165
136SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86394460
137SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86382912
138* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85976864
139* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85879322
140CDX2_20551321_ChIP-Seq_CACO-2_Human0.84796197
141OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83220437

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.27268562
2MP0005360_urolithiasis7.09627011
3MP0005085_abnormal_gallbladder_physiolo5.25989422
4MP0005365_abnormal_bile_salt4.89829773
5MP0005058_abnormal_lysosome_morphology4.69907180
6MP0008875_abnormal_xenobiotic_pharmacok3.90137664
7MP0005083_abnormal_biliary_tract3.44203835
8MP0005451_abnormal_body_composition3.29819392
9MP0009840_abnormal_foam_cell3.29235473
10MP0003172_abnormal_lysosome_physiology3.29100392
11MP0010329_abnormal_lipoprotein_level3.12785057
12MP0003252_abnormal_bile_duct3.08976965
13MP0003806_abnormal_nucleotide_metabolis3.04524839
14MP0003705_abnormal_hypodermis_morpholog2.68824756
15MP0001666_abnormal_nutrient_absorption2.53042370
16MP0003436_decreased_susceptibility_to2.48299260
17MP0005332_abnormal_amino_acid2.41323365
18MP0003123_paternal_imprinting2.35802001
19MP0009278_abnormal_bone_marrow2.31781980
20MP0006082_CNS_inflammation2.30523717
21MP0004510_myositis2.06601601
22MP0002148_abnormal_hypersensitivity_rea2.06579522
23MP0005025_abnormal_response_to1.93988048
24MP0003879_abnormal_hair_cell1.91395161
25MP0000609_abnormal_liver_physiology1.88104731
26MP0003183_abnormal_peptide_metabolism1.84548109
27MP0003191_abnormal_cellular_cholesterol1.84328926
28MP0002118_abnormal_lipid_homeostasis1.82976694
29MP0010234_abnormal_vibrissa_follicle1.80067062
30MP0002419_abnormal_innate_immunity1.75231396
31MP0001790_abnormal_immune_system1.71187724
32MP0005387_immune_system_phenotype1.71187724
33MP0005319_abnormal_enzyme/_coenzyme1.70633520
34MP0000343_altered_response_to1.61215853
35MP0004858_abnormal_nervous_system1.58461636
36MP0009785_altered_susceptibility_to1.56967536
37MP0009333_abnormal_splenocyte_physiolog1.55688361
38MP0004019_abnormal_vitamin_homeostasis1.54982529
39MP0002653_abnormal_ependyma_morphology1.54288368
40MP0000678_abnormal_parathyroid_gland1.53668996
41MP0003122_maternal_imprinting1.51383029
42MP0004130_abnormal_muscle_cell1.50174914
43MP0005000_abnormal_immune_tolerance1.49062968
44MP0008260_abnormal_autophagy1.47397481
45MP0005584_abnormal_enzyme/coenzyme_acti1.45486545
46MP0009053_abnormal_anal_canal1.44983255
47MP0005409_darkened_coat_color1.43195259
48MP0000685_abnormal_immune_system1.41454756
49MP0003329_amyloid_beta_deposits1.40160617
50MP0002837_dystrophic_cardiac_calcinosis1.39961863
51MP0005464_abnormal_platelet_physiology1.36218285
52MP0000604_amyloidosis1.36011638
53MP0008961_abnormal_basal_metabolism1.35708883
54MP0001835_abnormal_antigen_presentation1.34865985
55MP0001663_abnormal_digestive_system1.34208051
56MP0003724_increased_susceptibility_to1.31180920
57MP0003011_delayed_dark_adaptation1.27596874
58MP0003195_calcinosis1.27272935
59MP0002723_abnormal_immune_serum1.27192107
60MP0004859_abnormal_synaptic_plasticity1.25384604
61MP0010030_abnormal_orbit_morphology1.24916083
62MP0002452_abnormal_antigen_presenting1.23839881
63MP0000537_abnormal_urethra_morphology1.23788577
64MP0003868_abnormal_feces_composition1.23641521
65MP0003453_abnormal_keratinocyte_physiol1.22853326
66MP0003283_abnormal_digestive_organ1.22792300
67MP0009764_decreased_sensitivity_to1.22301644
68MP0002822_catalepsy1.20908510
69MP0001533_abnormal_skeleton_physiology1.20165965
70MP0009384_cardiac_valve_regurgitation1.20110740
71MP0001845_abnormal_inflammatory_respons1.19809404
72MP0001800_abnormal_humoral_immune1.19648079
73MP0005381_digestive/alimentary_phenotyp1.17626170
74MP0009643_abnormal_urine_homeostasis1.14630898
75MP0002138_abnormal_hepatobiliary_system1.14586966
76MP0005397_hematopoietic_system_phenotyp1.13030856
77MP0001545_abnormal_hematopoietic_system1.13030856
78MP0004142_abnormal_muscle_tone1.11520869
79MP0010155_abnormal_intestine_physiology1.10153081
80MP0005671_abnormal_response_to1.09966890
81MP0004043_abnormal_pH_regulation1.08645748
82MP0001819_abnormal_immune_cell1.07862459
83MP0002420_abnormal_adaptive_immunity1.07309834
84MP0005166_decreased_susceptibility_to1.06618163
85MP0002249_abnormal_larynx_morphology1.06048985
86MP0005310_abnormal_salivary_gland1.03208834
87MP0002998_abnormal_bone_remodeling0.98101391
88MP0000598_abnormal_liver_morphology0.97161704
89MP0004947_skin_inflammation0.95577047
90MP0004185_abnormal_adipocyte_glucose0.93802280
91MP0002405_respiratory_system_inflammati0.93654522
92MP0001873_stomach_inflammation0.92575239
93MP0003634_abnormal_glial_cell0.91387800
94MP0006036_abnormal_mitochondrial_physio0.91131062
95MP0003300_gastrointestinal_ulcer0.90456615
96MP0000750_abnormal_muscle_regeneration0.90047394
97MP0003690_abnormal_glial_cell0.88318074
98MP0002909_abnormal_adrenal_gland0.88142333
99MP0000751_myopathy0.88030485
100MP0002078_abnormal_glucose_homeostasis0.87460030
101MP0003315_abnormal_perineum_morphology0.86653376
102MP0000490_abnormal_crypts_of0.85852138
103MP0000858_altered_metastatic_potential0.84715889
104MP0000681_abnormal_thyroid_gland0.84472410
105MP0002277_abnormal_respiratory_mucosa0.84208066
106MP0000716_abnormal_immune_system0.82351754
107MP0002089_abnormal_postnatal_growth/wei0.82271229
108MP0006035_abnormal_mitochondrial_morpho0.81936986
109MP0003787_abnormal_imprinting0.80574291
110MP0006276_abnormal_autonomic_nervous0.79530168
111MP0008874_decreased_physiological_sensi0.78124119
112MP0005377_hearing/vestibular/ear_phenot0.77618091
113MP0003878_abnormal_ear_physiology0.77618091
114MP0009642_abnormal_blood_homeostasis0.77600171
115MP0009379_abnormal_foot_pigmentation0.77070460
116MP0009765_abnormal_xenobiotic_induced0.74812556
117MP0005666_abnormal_adipose_tissue0.73856455
118MP0003303_peritoneal_inflammation0.72284079
119MP0001756_abnormal_urination0.71617205
120MP0002429_abnormal_blood_cell0.69150965
121MP0009763_increased_sensitivity_to0.68885598
122MP0002971_abnormal_brown_adipose0.68883807
123MP0001764_abnormal_homeostasis0.68880955
124MP0005636_abnormal_mineral_homeostasis0.63790445
125MP0001727_abnormal_embryo_implantation0.62904853
126MP0002970_abnormal_white_adipose0.62077329
127MP0005334_abnormal_fat_pad0.61386284
128MP0003959_abnormal_lean_body0.61278017
129MP0005670_abnormal_white_adipose0.59617420
130MP0004133_heterotaxia0.59493521
131MP0003075_altered_response_to0.59310133
132MP0002733_abnormal_thermal_nociception0.58917211
133MP0005535_abnormal_body_temperature0.58762932
134MP0005448_abnormal_energy_balance0.58553204
135MP0003385_abnormal_body_wall0.58377157
136MP0003635_abnormal_synaptic_transmissio0.58333025
137MP0005375_adipose_tissue_phenotype0.58213260
138MP0003119_abnormal_digestive_system0.55679210
139MP0005187_abnormal_penis_morphology0.55557429
140MP0001348_abnormal_lacrimal_gland0.54850206
141MP0002282_abnormal_trachea_morphology0.53657421
142MP0008770_decreased_survivor_rate0.51350626
143MP0000516_abnormal_urinary_system0.50838007
144MP0005367_renal/urinary_system_phenotyp0.50838007
145MP0005220_abnormal_exocrine_pancreas0.50702100
146MP0000013_abnormal_adipose_tissue0.49907291
147MP0001968_abnormal_touch/_nociception0.49692130
148MP0004087_abnormal_muscle_fiber0.49417766
149MP0000955_abnormal_spinal_cord0.48945862
150MP0000003_abnormal_adipose_tissue0.48210323
151MP0000747_muscle_weakness0.48063773
152MP0001270_distended_abdomen0.47165057
153MP0000639_abnormal_adrenal_gland0.46757416
154MP0002932_abnormal_joint_morphology0.46625890
155MP0008872_abnormal_physiological_respon0.46470637
156MP0005167_abnormal_blood-brain_barrier0.46309118
157MP0005330_cardiomyopathy0.45516335
158MP0002069_abnormal_eating/drinking_beha0.45228647
159MP0003638_abnormal_response/metabolism_0.45001384
160MP0001849_ear_inflammation0.44703913
161MP0002184_abnormal_innervation0.44333840
162MP0008469_abnormal_protein_level0.44241320
163MP0002254_reproductive_system_inflammat0.44203405
164MP0001502_abnormal_circadian_rhythm0.44137623
165MP0002063_abnormal_learning/memory/cond0.44075478

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.17803772
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.89597084
3Abnormality of glycolipid metabolism (HP:0010969)5.13362695
4Abnormality of liposaccharide metabolism (HP:0010968)5.13362695
5Abnormality of glycosphingolipid metabolism (HP:0004343)5.13362695
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.87754793
7Xanthomatosis (HP:0000991)4.84435675
8Hypobetalipoproteinemia (HP:0003563)4.74094968
9Increased cerebral lipofuscin (HP:0011813)4.70575453
10Intrahepatic cholestasis (HP:0001406)4.65105132
11Prolonged partial thromboplastin time (HP:0003645)4.20405164
12Increased neuronal autofluorescent lipopigment (HP:0002074)4.18031455
13Complement deficiency (HP:0004431)3.99983529
14Ketosis (HP:0001946)3.82994750
15Hyperlipoproteinemia (HP:0010980)3.81505132
16Hyperammonemia (HP:0001987)3.71953322
17Hyperglycinemia (HP:0002154)3.70580872
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.61584579
19Dysostosis multiplex (HP:0000943)3.59901369
20Recurrent bacterial skin infections (HP:0005406)3.46268049
21Abnormality of macrophages (HP:0004311)3.38084544
22Hypolipoproteinemia (HP:0010981)3.35055168
23Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.34933216
24Eczematoid dermatitis (HP:0000976)3.31326239
25Recurrent abscess formation (HP:0002722)3.27419036
26Hyperglycinuria (HP:0003108)3.26438540
27Hypercholesterolemia (HP:0003124)3.23099263
28Epidermoid cyst (HP:0200040)3.19226093
29Vacuolated lymphocytes (HP:0001922)3.18134921
30Hyperacusis (HP:0010780)3.14900944
31Abnormality of glycine metabolism (HP:0010895)3.14450393
32Abnormality of serine family amino acid metabolism (HP:0010894)3.14450393
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.12923525
34Abnormality of complement system (HP:0005339)3.10609224
35Neurofibrillary tangles (HP:0002185)3.08011964
36Thoracic kyphosis (HP:0002942)3.05048793
37Spastic diplegia (HP:0001264)3.04157849
38Joint hemorrhage (HP:0005261)3.03489023
39Abnormality of the common coagulation pathway (HP:0010990)3.01768546
40Axonal loss (HP:0003447)3.00175691
41Abnormality of the Achilles tendon (HP:0005109)2.98806014
42Delayed CNS myelination (HP:0002188)2.97186301
43Prolonged neonatal jaundice (HP:0006579)2.97063649
44Abnormality of mucopolysaccharide metabolism (HP:0011020)2.94750192
45Abnormality of polysaccharide metabolism (HP:0011012)2.94750192
46Abnormality of glycosaminoglycan metabolism (HP:0004371)2.94750192
47Upper motor neuron abnormality (HP:0002127)2.93788784
48Neonatal onset (HP:0003623)2.90204274
49Abnormality of sulfur amino acid metabolism (HP:0004339)2.90026336
50Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.88736923
51Skin nodule (HP:0200036)2.85942272
52Lymphangioma (HP:0100764)2.84548665
53Loss of speech (HP:0002371)2.84408770
54Hypoalphalipoproteinemia (HP:0003233)2.81906370
55Ketoacidosis (HP:0001993)2.79297977
56Mutism (HP:0002300)2.78056573
57Purpura (HP:0000979)2.74753130
58Recurrent gram-negative bacterial infections (HP:0005420)2.72776043
59Chronic obstructive pulmonary disease (HP:0006510)2.72553640
60Obstructive lung disease (HP:0006536)2.72553640
61Urinary glycosaminoglycan excretion (HP:0003541)2.67807801
62Mucopolysacchariduria (HP:0008155)2.67807801
63Disinhibition (HP:0000734)2.67393775
64Abnormality of the thoracic spine (HP:0100711)2.66889112
65Neuronal loss in central nervous system (HP:0002529)2.65957638
66Abnormality of aspartate family amino acid metabolism (HP:0010899)2.65477723
67Glomerulonephritis (HP:0000099)2.59939877
68Thin bony cortex (HP:0002753)2.57408594
69Abnormality of pyrimidine metabolism (HP:0004353)2.54992705
70Abnormality of the intrinsic pathway (HP:0010989)2.54075706
71Increased serum ferritin (HP:0003281)2.48587999
72Achilles tendon contracture (HP:0001771)2.47478593
73Fat malabsorption (HP:0002630)2.46564983
74Failure to thrive in infancy (HP:0001531)2.46082124
75Cerebral inclusion bodies (HP:0100314)2.45655573
76Hyperthyroidism (HP:0000836)2.43256854
77Hypoglycemic coma (HP:0001325)2.37578171
78Abnormality of methionine metabolism (HP:0010901)2.36129808
79Back pain (HP:0003418)2.35981517
80Supranuclear gaze palsy (HP:0000605)2.34400609
81Abnormality of fatty-acid metabolism (HP:0004359)2.32959186
82Turricephaly (HP:0000262)2.32394116
83Hyperparathyroidism (HP:0000843)2.30840199
84Reticulocytopenia (HP:0001896)2.30664041
85Abnormality of cells of the erythroid lineage (HP:0012130)2.30060701
86Congenital malformation of the right heart (HP:0011723)2.28185145
87Double outlet right ventricle (HP:0001719)2.28185145
88Late onset (HP:0003584)2.27805919
89Gout (HP:0001997)2.27511444
90Abnormality of nucleobase metabolism (HP:0010932)2.26406618
91Mediastinal lymphadenopathy (HP:0100721)2.24709663
92Abnormal cartilage morphology (HP:0002763)2.24318895
93Bulbar palsy (HP:0001283)2.23488152
94Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.22090195
95Truncus arteriosus (HP:0001660)2.21967704
96Polygenic inheritance (HP:0010982)2.21665556
97Polyphagia (HP:0002591)2.21645241
98Dementia (HP:0000726)2.19318230
99Nuclear cataract (HP:0100018)2.14545478
100Cerebral edema (HP:0002181)2.12777279
101Abnormality of purine metabolism (HP:0004352)2.12113574
102Hypophosphatemia (HP:0002148)2.10979271
103Progressive neurologic deterioration (HP:0002344)2.10187947
104Hyperbilirubinemia (HP:0002904)2.07000419
105Agitation (HP:0000713)2.06497351
106Myokymia (HP:0002411)2.06354331
107Personality changes (HP:0000751)2.06280345
108Lethargy (HP:0001254)2.05749576
109Diminished motivation (HP:0000745)2.04092127
110Angiofibromas (HP:0010615)2.03607864
111Adenoma sebaceum (HP:0009720)2.03607864
112Spontaneous abortion (HP:0005268)2.03160942
113Pathologic fracture (HP:0002756)2.01578445
114Hypercortisolism (HP:0001578)2.00453150
115Autoimmune thrombocytopenia (HP:0001973)1.99783476
116Pseudobulbar signs (HP:0002200)1.99312636
117Myoglobinuria (HP:0002913)1.97851464
118Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95641132
119Focal dystonia (HP:0004373)1.95450107
120Increased IgE level (HP:0003212)1.94387877
121Hepatocellular carcinoma (HP:0001402)1.93632869
122Cholecystitis (HP:0001082)1.92676736
123Abnormal gallbladder physiology (HP:0012438)1.92676736
124Malnutrition (HP:0004395)1.92642797
125Annular pancreas (HP:0001734)1.91468104
126Amyloidosis (HP:0011034)1.91422286
127Colitis (HP:0002583)1.90616809
128Abnormality of the aortic arch (HP:0012303)1.90504816
129Orchitis (HP:0100796)1.90383520
130Hypertensive crisis (HP:0100735)1.90276969
131Long toe (HP:0010511)1.90266486
132Cholelithiasis (HP:0001081)1.88437849
133Status epilepticus (HP:0002133)1.88422913
134Microretrognathia (HP:0000308)1.86332224
135Abnormality of serum amino acid levels (HP:0003112)1.85407953
136Recurrent skin infections (HP:0001581)1.85283800
137Visual hallucinations (HP:0002367)1.84674321
138Large eyes (HP:0001090)1.84102847
139Ragged-red muscle fibers (HP:0003200)1.83851387
140Myopathic facies (HP:0002058)1.83744317
141Abnormal number of erythroid precursors (HP:0012131)1.82487547
142Abnormality of the nasal mucosa (HP:0000433)1.82210778
143Cellulitis (HP:0100658)1.81827698
144Broad distal phalanx of finger (HP:0009836)1.81616310
145Cardiomegaly (HP:0001640)1.81198264
146Irritability (HP:0000737)1.80704141
147Dicarboxylic aciduria (HP:0003215)1.80680487
148Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80680487
149Apathy (HP:0000741)1.79786610
150Gingivitis (HP:0000230)1.79343875
151Visceral angiomatosis (HP:0100761)1.79287354
152Bone pain (HP:0002653)1.79167179
153Metabolic acidosis (HP:0001942)1.79013886
154Systemic lupus erythematosus (HP:0002725)1.78309863
155Abnormality of the lower motor neuron (HP:0002366)1.78245907
156Vomiting (HP:0002013)1.77361482
157Abnormality of iron homeostasis (HP:0011031)1.75682579
158Elevated erythrocyte sedimentation rate (HP:0003565)1.75493246
159Myositis (HP:0100614)1.74367089
160Global brain atrophy (HP:0002283)1.74353657
161Anomalous pulmonary venous return (HP:0010772)1.73563197
162Asymmetric septal hypertrophy (HP:0001670)1.73198438
163Abnormal gallbladder morphology (HP:0012437)1.72201840
164Increased muscle lipid content (HP:0009058)1.72006999
165Hepatic necrosis (HP:0002605)1.71605131
166Acne (HP:0001061)1.70673662
167Renovascular hypertension (HP:0100817)1.70257068
168Impaired vibration sensation in the lower limbs (HP:0002166)1.70138903
169Hypochromic microcytic anemia (HP:0004840)1.69162497
170Conjugated hyperbilirubinemia (HP:0002908)1.67697707
171Mitral stenosis (HP:0001718)1.67401981
172Esophageal varix (HP:0002040)1.67028344
173Hamartoma of the eye (HP:0010568)1.65164518
174Myocardial infarction (HP:0001658)1.64967639
175Sensorimotor neuropathy (HP:0007141)1.64544293
176Craniofacial dystonia (HP:0012179)1.63495586
177Hydroxyprolinuria (HP:0003080)1.63438069
178Abnormality of proline metabolism (HP:0010907)1.63438069
179Hemorrhage of the eye (HP:0011885)1.61766817
180Multiple enchondromatosis (HP:0005701)1.59158611
181Hemangiomatosis (HP:0007461)1.57893994
182Hepatocellular necrosis (HP:0001404)1.57857455

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.50672760
2TRIB34.59806644
3PKN23.79528817
4BCKDK3.37097403
5SMG12.92025551
6IRAK32.65168761
7ERN12.53048475
8PRPF4B2.31288353
9MAP3K92.30247813
10SIK12.17758095
11TLK12.15760933
12MAP3K102.08279192
13KSR22.03181560
14EPHB22.00223206
15FGFR41.98478163
16ICK1.88777599
17EEF2K1.83449293
18MAP2K31.82666005
19DYRK1B1.65734855
20PTK61.64491475
21RIPK41.59461253
22TAOK31.57496632
23MAP4K11.54281831
24MAP3K71.52919646
25IRAK41.51441117
26LMTK21.51035674
27DAPK21.51022913
28VRK21.46716518
29KSR11.44190253
30MAP2K41.42509175
31PRKD21.32515274
32BRAF1.30182648
33SCYL21.29870302
34PIM21.29730365
35PRKD31.27418123
36TESK11.24915243
37GRK61.24484769
38MAP2K21.20209798
39ERBB21.18659513
40DAPK31.15462812
41RIPK11.14223791
42LATS21.09796706
43GRK71.09531560
44MAP3K111.08616260
45PDGFRA1.04458536
46PAK61.03739633
47LRRK21.02238500
48MAPK111.00981610
49SIK20.99492961
50DYRK30.99105044
51TTN0.98237502
52PHKG20.97071960
53PHKG10.97071960
54FLT30.93542850
55ABL20.91228955
56EPHB10.89721346
57ILK0.89460143
58CSK0.86461486
59MAP3K30.85666046
60TYRO30.85318576
61TBK10.85171014
62MAP3K130.83601098
63MARK20.82800675
64NME20.81844675
65MAP2K60.81487414
66LIMK10.80376943
67MATK0.80368179
68RET0.80267003
69CAMK40.79175175
70HIPK20.78130531
71MARK10.77305322
72CAMK1D0.75654057
73MAP3K20.74734232
74PKN10.74410546
75MAP3K140.73617848
76IKBKB0.73542803
77UHMK10.72964839
78NTRK10.72940249
79DYRK20.72511930
80PRKCZ0.72086572
81PTK20.70527482
82TNK20.69807546
83STK160.67783531
84FES0.67704527
85TESK20.67484934
86CAMKK10.67416924
87IRAK10.67196413
88BMX0.64431909
89MINK10.64406698
90ARAF0.62304924
91PRKAA20.58833705
92MAP3K40.58179738
93CDK11A0.57105750
94PDPK10.56836283
95RPS6KA20.56353773
96CDC42BPA0.55377455
97STK380.55045579
98DMPK0.55037513
99DDR20.53580707
100PRKD10.52947602
101PRKAA10.52527881
102IRAK20.52116856
103ALK0.51513378
104MAP2K10.50852838
105IKBKE0.50513103
106PAK30.50196402
107CDK150.48864088
108EPHA40.47724739
109TAOK10.47675595
110MAPK40.47489162
111MST1R0.47124041
112JAK20.46930686
113MUSK0.46800140
114DAPK10.45952884
115PRKG20.44974562
116MAP3K10.44783004
117PAK40.42937197
118PAK10.42664592
119CDK140.42422163
120CSF1R0.42299646
121BTK0.41832948
122MTOR0.41456322
123CDK190.40614541
124MOS0.40056066
125CAMK10.39596091
126ERBB40.38741855
127PRKCH0.38422844
128MAP3K80.38202354
129STK110.37993306
130CDK50.37824884
131PDK10.36929614
132LYN0.36878505
133RPS6KL10.36532072
134RPS6KC10.36532072
135MAPK120.35772009
136RPS6KA10.35127345
137PRKCI0.34920320
138TAOK20.34804087
139BLK0.34616120
140RPS6KA60.33528041
141FGFR20.31904744
142PAK20.31617233
143TYK20.30975436

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.18312462
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.04100695
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.02046287
4Nitrogen metabolism_Homo sapiens_hsa009103.83701786
5Arginine biosynthesis_Homo sapiens_hsa002203.52635477
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.07004097
7Lysosome_Homo sapiens_hsa041422.93485420
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.75291370
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.67052006
10Tryptophan metabolism_Homo sapiens_hsa003802.57494542
11Fatty acid degradation_Homo sapiens_hsa000712.46067534
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43122381
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.36395586
14Butanoate metabolism_Homo sapiens_hsa006502.24609335
15Complement and coagulation cascades_Homo sapiens_hsa046102.14576982
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.05174826
17Osteoclast differentiation_Homo sapiens_hsa043801.99315666
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.95994269
19Propanoate metabolism_Homo sapiens_hsa006401.92641253
20Notch signaling pathway_Homo sapiens_hsa043301.75962807
21Leishmaniasis_Homo sapiens_hsa051401.75874042
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75511276
23PPAR signaling pathway_Homo sapiens_hsa033201.74745364
24Bile secretion_Homo sapiens_hsa049761.71703299
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66269821
26Fatty acid metabolism_Homo sapiens_hsa012121.64686413
27Sulfur relay system_Homo sapiens_hsa041221.58809792
28Peroxisome_Homo sapiens_hsa041461.57261907
29Biosynthesis of amino acids_Homo sapiens_hsa012301.55576408
30beta-Alanine metabolism_Homo sapiens_hsa004101.55411162
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54556796
32Pyruvate metabolism_Homo sapiens_hsa006201.52375600
33Tuberculosis_Homo sapiens_hsa051521.51827789
34Carbon metabolism_Homo sapiens_hsa012001.49837962
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43923894
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41454585
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41153859
38Fat digestion and absorption_Homo sapiens_hsa049751.39719376
39B cell receptor signaling pathway_Homo sapiens_hsa046621.37270648
40Chemical carcinogenesis_Homo sapiens_hsa052041.34102343
41Histidine metabolism_Homo sapiens_hsa003401.33050201
42Phenylalanine metabolism_Homo sapiens_hsa003601.30884803
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27892892
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.27198867
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27017698
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.26456632
47Rheumatoid arthritis_Homo sapiens_hsa053231.24068328
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.23654006
49Acute myeloid leukemia_Homo sapiens_hsa052211.21399263
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20945478
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19478610
52Pertussis_Homo sapiens_hsa051331.19418794
53Tyrosine metabolism_Homo sapiens_hsa003501.18921599
54Asthma_Homo sapiens_hsa053101.18548515
55Staphylococcus aureus infection_Homo sapiens_hsa051501.15261300
56Phagosome_Homo sapiens_hsa041451.12355433
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11794439
58Steroid hormone biosynthesis_Homo sapiens_hsa001401.10437255
59Salmonella infection_Homo sapiens_hsa051321.09800665
60Caffeine metabolism_Homo sapiens_hsa002321.07677665
61Collecting duct acid secretion_Homo sapiens_hsa049661.04740447
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03102824
63Allograft rejection_Homo sapiens_hsa053301.01839499
64Starch and sucrose metabolism_Homo sapiens_hsa005001.01572331
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.98250018
66Selenocompound metabolism_Homo sapiens_hsa004500.96082259
67Sulfur metabolism_Homo sapiens_hsa009200.94371150
68Arginine and proline metabolism_Homo sapiens_hsa003300.93980857
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93056171
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91734423
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90508267
72Lysine degradation_Homo sapiens_hsa003100.89816533
73Retinol metabolism_Homo sapiens_hsa008300.89323330
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.89082542
75Vibrio cholerae infection_Homo sapiens_hsa051100.87824294
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87428622
77Hepatitis C_Homo sapiens_hsa051600.87122065
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86683084
79TNF signaling pathway_Homo sapiens_hsa046680.84324681
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83693512
81Malaria_Homo sapiens_hsa051440.83126101
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.80419560
83Chemokine signaling pathway_Homo sapiens_hsa040620.79406586
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77319950
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.77193744
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76318149
87Folate biosynthesis_Homo sapiens_hsa007900.71434362
88Sphingolipid metabolism_Homo sapiens_hsa006000.69870192
89Prion diseases_Homo sapiens_hsa050200.68321872
90ABC transporters_Homo sapiens_hsa020100.68032371
91Autoimmune thyroid disease_Homo sapiens_hsa053200.67390660
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67196499
93Fatty acid elongation_Homo sapiens_hsa000620.65937330
94African trypanosomiasis_Homo sapiens_hsa051430.64108519
95Influenza A_Homo sapiens_hsa051640.62112205
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.61787662
97Pentose phosphate pathway_Homo sapiens_hsa000300.59469118
98Bladder cancer_Homo sapiens_hsa052190.59328536
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.59237058
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58522166
101Glycerolipid metabolism_Homo sapiens_hsa005610.57068696
102Graft-versus-host disease_Homo sapiens_hsa053320.56370240
103Toxoplasmosis_Homo sapiens_hsa051450.54543074
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.53055614
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52975269
106Chronic myeloid leukemia_Homo sapiens_hsa052200.52268884
107Fructose and mannose metabolism_Homo sapiens_hsa000510.50020835
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47713415
109Insulin signaling pathway_Homo sapiens_hsa049100.45878489
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.45866179
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45678566
112Endocytosis_Homo sapiens_hsa041440.45489723
113Insulin resistance_Homo sapiens_hsa049310.45421300
114Mineral absorption_Homo sapiens_hsa049780.45132750
115Apoptosis_Homo sapiens_hsa042100.42771656
116Galactose metabolism_Homo sapiens_hsa000520.42332406
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41789524
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.39719470
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39248061
120Parkinsons disease_Homo sapiens_hsa050120.38491441
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37335850
122AMPK signaling pathway_Homo sapiens_hsa041520.37167101
123Amoebiasis_Homo sapiens_hsa051460.34789178
124Glutathione metabolism_Homo sapiens_hsa004800.33027747
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32856232
126Cardiac muscle contraction_Homo sapiens_hsa042600.31313296
127Ribosome_Homo sapiens_hsa030100.30526754
128One carbon pool by folate_Homo sapiens_hsa006700.30403037
129Oxidative phosphorylation_Homo sapiens_hsa001900.29692014
130Glucagon signaling pathway_Homo sapiens_hsa049220.28762565
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28705363
132Fatty acid biosynthesis_Homo sapiens_hsa000610.28187499
133Steroid biosynthesis_Homo sapiens_hsa001000.25760437
134Non-small cell lung cancer_Homo sapiens_hsa052230.24758182
135Alzheimers disease_Homo sapiens_hsa050100.23960424
136VEGF signaling pathway_Homo sapiens_hsa043700.23367462
137Metabolic pathways_Homo sapiens_hsa011000.22045329
138Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19271510
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17794816
140Endometrial cancer_Homo sapiens_hsa052130.15608897
141mTOR signaling pathway_Homo sapiens_hsa041500.15204351
142Thyroid cancer_Homo sapiens_hsa052160.14943785
143Glioma_Homo sapiens_hsa052140.11075417
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.10741103
145Gap junction_Homo sapiens_hsa045400.10233686
146Thyroid hormone synthesis_Homo sapiens_hsa049180.10037107
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.09426023
148Synaptic vesicle cycle_Homo sapiens_hsa047210.09141659
149Glycosaminoglycan degradation_Homo sapiens_hsa005310.08874971
150Melanogenesis_Homo sapiens_hsa049160.07988462
151GnRH signaling pathway_Homo sapiens_hsa049120.07425068

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