MPO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular extravasation (GO:0045123)8.87078050
2disruption of cells of other organism involved in symbiotic interaction (GO:0051818)8.23803468
3killing of cells in other organism involved in symbiotic interaction (GO:0051883)8.23803468
4neutrophil mediated immunity (GO:0002446)8.17735103
5negative regulation of phagocytosis (GO:0050765)6.88919549
6myeloid leukocyte mediated immunity (GO:0002444)6.49936538
7positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)6.38039700
8killing of cells of other organism (GO:0031640)6.23455592
9disruption of cells of other organism (GO:0044364)6.23455592
10DNA deamination (GO:0045006)6.07866858
11ribosomal small subunit assembly (GO:0000028)5.62256969
12* negative regulation of growth of symbiont in host (GO:0044130)5.30383843
13* negative regulation of growth of symbiont involved in interaction with host (GO:0044146)5.30383843
14* modulation of growth of symbiont involved in interaction with host (GO:0044144)5.30383843
15* regulation of growth of symbiont in host (GO:0044126)5.30383843
16protoporphyrinogen IX biosynthetic process (GO:0006782)5.24188611
17negative regulation of interleukin-8 production (GO:0032717)5.22280989
18regulation of MHC class II biosynthetic process (GO:0045346)5.20066950
19DNA strand elongation involved in DNA replication (GO:0006271)5.06210723
20microglial cell activation (GO:0001774)5.04662246
21positive regulation of B cell differentiation (GO:0045579)5.00563985
22cellular response to zinc ion (GO:0071294)4.90706088
23telomere maintenance via semi-conservative replication (GO:0032201)4.88223622
24positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.83495981
25DNA strand elongation (GO:0022616)4.83417202
26response to peptidoglycan (GO:0032494)4.75796028
27protoporphyrinogen IX metabolic process (GO:0046501)4.66166277
28leukocyte mediated cytotoxicity (GO:0001909)4.59578560
29regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.56089287
30purine deoxyribonucleotide catabolic process (GO:0009155)4.47865710
31cell wall macromolecule catabolic process (GO:0016998)4.38321011
32positive regulation of chemokine biosynthetic process (GO:0045080)4.35247574
33* response to fungus (GO:0009620)4.17710037
34telomere maintenance via recombination (GO:0000722)4.13730898
35DNA replication initiation (GO:0006270)4.04886646
36innate immune response in mucosa (GO:0002227)4.02723831
37nucleobase biosynthetic process (GO:0046112)3.94887534
38DNA unwinding involved in DNA replication (GO:0006268)3.93763070
39IMP metabolic process (GO:0046040)3.92908129
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.87561187
41glucose 6-phosphate metabolic process (GO:0051156)3.81414833
42cotranslational protein targeting to membrane (GO:0006613)3.79564045
43protein targeting to ER (GO:0045047)3.75861800
44mitotic recombination (GO:0006312)3.75586869
45centriole replication (GO:0007099)3.73470136
46negative regulation of erythrocyte differentiation (GO:0045647)3.70732540
47angiotensin maturation (GO:0002003)3.67837188
48protein localization to endoplasmic reticulum (GO:0070972)3.61800005
49IMP biosynthetic process (GO:0006188)3.61574011
50cell wall macromolecule metabolic process (GO:0044036)3.60445446
51DNA replication checkpoint (GO:0000076)3.59007232
52telomere maintenance via telomere lengthening (GO:0010833)3.57941082
53establishment of protein localization to endoplasmic reticulum (GO:0072599)3.56526360
54positive regulation of gamma-delta T cell activation (GO:0046645)3.55794489
55L-fucose catabolic process (GO:0042355)3.53233775
56fucose catabolic process (GO:0019317)3.53233775
57L-fucose metabolic process (GO:0042354)3.53233775
58pentose-phosphate shunt (GO:0006098)3.51328224
59angiogenesis involved in wound healing (GO:0060055)3.50175566
60positive regulation of granulocyte differentiation (GO:0030854)3.49986350
61viral transcription (GO:0019083)3.48082112
62antibacterial humoral response (GO:0019731)3.44651516
63translational termination (GO:0006415)3.41370176
64pentose metabolic process (GO:0019321)3.36821015
65signal peptide processing (GO:0006465)3.36376354
66nucleotide-excision repair, DNA gap filling (GO:0006297)3.34899235
67NADPH regeneration (GO:0006740)3.34716251
68regulation of phagocytosis (GO:0050764)3.32259725
69macrophage chemotaxis (GO:0048246)3.28805093
70* defense response to fungus (GO:0050832)3.28596634
71mannose metabolic process (GO:0006013)3.28028636
72neutrophil activation involved in immune response (GO:0002283)3.25454656
73purine deoxyribonucleotide metabolic process (GO:0009151)3.24626531
74cell killing (GO:0001906)3.24344511
75CENP-A containing nucleosome assembly (GO:0034080)3.23906724
76protein localization to kinetochore (GO:0034501)3.22618493
77regulation of interleukin-8 biosynthetic process (GO:0045414)3.22241789
78deoxyribose phosphate catabolic process (GO:0046386)3.21020157
79Arp2/3 complex-mediated actin nucleation (GO:0034314)3.20646746
80positive regulation of histone H3-K4 methylation (GO:0051571)3.18742316
81antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.18214017
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.18214017
83deoxyribonucleotide catabolic process (GO:0009264)3.16767234
84antimicrobial humoral response (GO:0019730)3.16067729
85purine nucleobase biosynthetic process (GO:0009113)3.15085884
86translational elongation (GO:0006414)3.14416894
87negative regulation of chemokine production (GO:0032682)3.14063733
88chromatin remodeling at centromere (GO:0031055)3.12648277
89heme biosynthetic process (GO:0006783)3.12073249
90deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.09692597
91regulation of chemokine biosynthetic process (GO:0045073)3.08567121
92mucosal immune response (GO:0002385)3.07615167
93response to muramyl dipeptide (GO:0032495)3.06898774
94ribosomal small subunit biogenesis (GO:0042274)3.04424684
95pseudouridine synthesis (GO:0001522)3.03662003
96interaction with symbiont (GO:0051702)2.98978142
97regulation of B cell differentiation (GO:0045577)2.96453243
98auditory receptor cell differentiation (GO:0042491)2.95593529
99organ or tissue specific immune response (GO:0002251)2.94666635
100macrophage activation (GO:0042116)2.94600134
101positive regulation of megakaryocyte differentiation (GO:0045654)2.92631105
102maturation of SSU-rRNA (GO:0030490)2.91221115
103regulation of myeloid leukocyte mediated immunity (GO:0002886)2.90802907
104leukotriene biosynthetic process (GO:0019370)2.90608752
105negative regulation of B cell apoptotic process (GO:0002903)2.90097799
106positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.89965716
107mast cell activation (GO:0045576)2.88594108
108pinocytosis (GO:0006907)2.88045599
109dosage compensation (GO:0007549)2.86951789
110UV protection (GO:0009650)2.83827356
111centriole assembly (GO:0098534)2.83054145
112regulation of female gonad development (GO:2000194)2.81259354
113glial cell migration (GO:0008347)2.78431527
114macrophage differentiation (GO:0030225)2.77842641
115leukocyte degranulation (GO:0043299)2.77253816
116induction of positive chemotaxis (GO:0050930)2.76085710
117hemoglobin metabolic process (GO:0020027)2.74572937
118intra-S DNA damage checkpoint (GO:0031573)2.73975428
119protein localization to chromosome, centromeric region (GO:0071459)2.72358055
120pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.72063591
121purine nucleobase metabolic process (GO:0006144)2.70982818
122base-excision repair, AP site formation (GO:0006285)2.70433879
123cellular protein complex disassembly (GO:0043624)2.70108906
124DNA topological change (GO:0006265)2.69812927
125heart process (GO:0003015)2.69138466
126heart contraction (GO:0060047)2.69138466
127porphyrin-containing compound biosynthetic process (GO:0006779)2.69087804
128definitive hemopoiesis (GO:0060216)2.68835342
129DNA replication-independent nucleosome organization (GO:0034724)2.68792614
130DNA replication-independent nucleosome assembly (GO:0006336)2.68792614
131cellular response to exogenous dsRNA (GO:0071360)2.67769249
132defense response to bacterium (GO:0042742)2.67497531
133positive regulation of phagocytosis (GO:0050766)2.67324618
134regulation of mast cell degranulation (GO:0043304)2.66351461
135necroptotic process (GO:0070266)2.65600259
136translational initiation (GO:0006413)2.65157522
137protein complex disassembly (GO:0043241)2.65026233
138mast cell activation involved in immune response (GO:0002279)2.64506001
139mast cell degranulation (GO:0043303)2.64506001
140kinetochore organization (GO:0051383)2.64264242
141regulation of leukocyte degranulation (GO:0043300)2.63982429
142regulation of gamma-delta T cell differentiation (GO:0045586)2.63753156
143nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.63048665
144nucleobase-containing small molecule interconversion (GO:0015949)2.62231113
145mitotic nuclear envelope disassembly (GO:0007077)2.61633510
146negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.60901028
147telomere maintenance (GO:0000723)2.60878434
148antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.60422279
149telomere organization (GO:0032200)2.58535806
150translation (GO:0006412)2.58279477
151translesion synthesis (GO:0019985)2.58252596
152exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.57577494
153formation of translation preinitiation complex (GO:0001731)2.57080340
154pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.55665024
155viral mRNA export from host cell nucleus (GO:0046784)2.53566106
156anterograde synaptic vesicle transport (GO:0048490)2.52568774
157modification by host of symbiont morphology or physiology (GO:0051851)2.51626829
1583-UTR-mediated mRNA stabilization (GO:0070935)2.51350349
159rRNA processing (GO:0006364)2.50870455
160viral life cycle (GO:0019058)2.50601704

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.63155510
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91535652
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.38582693
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.26813847
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07055036
6* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.02841525
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.94385448
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85692517
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.74284331
10* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.59738208
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57710695
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56314237
13VDR_21846776_ChIP-Seq_THP-1_Human2.55949266
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.54552094
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.50861930
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48675676
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42564843
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.28533538
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.27223752
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26422121
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24515942
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23717163
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18778971
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10180391
25* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.06254510
26* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04301424
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01602099
28VDR_23849224_ChIP-Seq_CD4+_Human2.00719915
29SCL_19346495_ChIP-Seq_HPC-7_Human1.98132231
30FOXP3_21729870_ChIP-Seq_TREG_Human1.94831722
31GATA1_22025678_ChIP-Seq_K562_Human1.94529319
32* SPI1_23547873_ChIP-Seq_NB4_Human1.90982998
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90508604
34SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.88391624
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.85433121
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.85375151
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.81813858
38ERG_20887958_ChIP-Seq_HPC-7_Mouse1.80916893
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.79971680
40XRN2_22483619_ChIP-Seq_HELA_Human1.79093033
41* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72935158
42MYC_22102868_ChIP-Seq_BL_Human1.72576105
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72369424
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69533768
45DCP1A_22483619_ChIP-Seq_HELA_Human1.67921940
46CIITA_25753668_ChIP-Seq_RAJI_Human1.67711836
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66115916
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65620279
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.65160005
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63634623
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.62822601
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62416916
53* VDR_24763502_ChIP-Seq_THP-1_Human1.61675742
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.60819970
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.59888256
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57516212
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57369820
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55881378
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54574715
60GABP_19822575_ChIP-Seq_HepG2_Human1.52313518
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50628568
62IRF8_22096565_ChIP-ChIP_GC-B_Human1.48947782
63MAF_26560356_Chip-Seq_TH2_Human1.45720811
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43185839
65AR_21909140_ChIP-Seq_LNCAP_Human1.42848731
66* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.40403159
67TTF2_22483619_ChIP-Seq_HELA_Human1.39931246
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.38411774
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.35337473
70SPI1_23127762_ChIP-Seq_K562_Human1.35017986
71ELK1_19687146_ChIP-ChIP_HELA_Human1.33562819
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32943152
73NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32744338
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31994413
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31075853
76ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30674605
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29586292
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28952660
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28801634
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28726593
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28616930
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28395503
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24944425
84MYB_26560356_Chip-Seq_TH2_Human1.24545278
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23083221
86* TCF7_22412390_ChIP-Seq_EML_Mouse1.22138156
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18054793
88GATA1_19941827_ChIP-Seq_MEL_Mouse1.16482157
89* LXR_22292898_ChIP-Seq_THP-1_Human1.16280594
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14580782
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14399747
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12595700
93* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12014763
94RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10668032
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10510339
96NCOR1_26117541_ChIP-Seq_K562_Human1.10127284
97MYB_26560356_Chip-Seq_TH1_Human1.10014050
98KDM2B_26808549_Chip-Seq_DND41_Human1.09110929
99ETS1_22383799_ChIP-Seq_G1ME_Mouse1.08595077
100BCL6_27268052_Chip-Seq_Bcells_Human1.08327462
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08306449
102SPI1_20517297_ChIP-Seq_HL60_Human1.06937867
103VDR_24787735_ChIP-Seq_THP-1_Human1.06621033
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06215731
105PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05823331
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05746281
107IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04254452
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03870966
109P68_20966046_ChIP-Seq_HELA_Human1.03867009
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03455096
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02246500
112EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01538021
113* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01355428
114UTX_26944678_Chip-Seq_JUKART_Human1.00509101
115IRF8_27001747_Chip-Seq_BMDM_Mouse0.99831089
116KDM5A_27292631_Chip-Seq_BREAST_Human0.99723240
117ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98890657
118TFEB_21752829_ChIP-Seq_HELA_Human0.98067988
119* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97617133
120MAF_26560356_Chip-Seq_TH1_Human0.96743815
121* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96720496
122FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95062073
123STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94648781
124PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92419443
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90556721
126PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90407173
127FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88608295
128PU_27001747_Chip-Seq_BMDM_Mouse0.87923846
129MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.87212886
130PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86748343

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.87936387
2MP0003693_abnormal_embryo_hatching4.17947949
3MP0008057_abnormal_DNA_replication3.42888499
4MP0010094_abnormal_chromosome_stability3.37962613
5MP0002166_altered_tumor_susceptibility3.14220604
6MP0005083_abnormal_biliary_tract2.95639836
7MP0003111_abnormal_nucleus_morphology2.80130222
8MP0009278_abnormal_bone_marrow2.72997543
9MP0001835_abnormal_antigen_presentation2.62001581
10MP0009785_altered_susceptibility_to2.57020308
11MP0003172_abnormal_lysosome_physiology2.56181011
12MP0003183_abnormal_peptide_metabolism2.52699601
13* MP0002419_abnormal_innate_immunity2.50040125
14MP0002006_tumorigenesis2.48889169
15MP0003436_decreased_susceptibility_to2.48725627
16MP0003077_abnormal_cell_cycle2.44566391
17MP0005174_abnormal_tail_pigmentation2.43249333
18MP0004957_abnormal_blastocyst_morpholog2.41727031
19MP0000490_abnormal_crypts_of2.33410062
20MP0002148_abnormal_hypersensitivity_rea2.24015667
21MP0008058_abnormal_DNA_repair2.23879011
22* MP0005025_abnormal_response_to2.22886729
23MP0003724_increased_susceptibility_to2.20733505
24MP0005075_abnormal_melanosome_morpholog2.14010892
25MP0003303_peritoneal_inflammation2.13983248
26MP0001545_abnormal_hematopoietic_system2.12574774
27MP0005397_hematopoietic_system_phenotyp2.12574774
28MP0005464_abnormal_platelet_physiology2.04944072
29MP0000465_gastrointestinal_hemorrhage2.04088713
30MP0000858_altered_metastatic_potential1.98134383
31MP0006054_spinal_hemorrhage1.87630151
32MP0009333_abnormal_splenocyte_physiolog1.84051736
33MP0004808_abnormal_hematopoietic_stem1.81432889
34MP0002009_preneoplasia1.80987076
35* MP0002420_abnormal_adaptive_immunity1.79756476
36MP0002877_abnormal_melanocyte_morpholog1.77968303
37MP0002398_abnormal_bone_marrow1.76732558
38MP0000569_abnormal_digit_pigmentation1.75978583
39* MP0001819_abnormal_immune_cell1.75446851
40MP0008007_abnormal_cellular_replicative1.73912077
41MP0003763_abnormal_thymus_physiology1.72269035
42MP0008961_abnormal_basal_metabolism1.69548125
43MP0005671_abnormal_response_to1.60369391
44* MP0000716_abnormal_immune_system1.59915700
45* MP0005000_abnormal_immune_tolerance1.56989166
46MP0002019_abnormal_tumor_incidence1.55258500
47MP0004185_abnormal_adipocyte_glucose1.54232269
48MP0002095_abnormal_skin_pigmentation1.53062019
49MP0002452_abnormal_antigen_presenting1.52788315
50MP0009379_abnormal_foot_pigmentation1.51692435
51MP0002722_abnormal_immune_system1.51565441
52MP0005220_abnormal_exocrine_pancreas1.50506561
53MP0004742_abnormal_vestibular_system1.50368496
54MP0001853_heart_inflammation1.50027400
55* MP0002429_abnormal_blood_cell1.49505543
56MP0000689_abnormal_spleen_morphology1.49387578
57MP0000343_altered_response_to1.48623539
58MP0010307_abnormal_tumor_latency1.48526658
59MP0000015_abnormal_ear_pigmentation1.47378074
60MP0002723_abnormal_immune_serum1.47155418
61MP0001800_abnormal_humoral_immune1.41658772
62MP0003186_abnormal_redox_activity1.39217659
63MP0010155_abnormal_intestine_physiology1.38418443
64MP0003866_abnormal_defecation1.35548880
65MP0008995_early_reproductive_senescence1.33154889
66MP0005076_abnormal_cell_differentiation1.30627582
67* MP0001845_abnormal_inflammatory_respons1.29882503
68MP0002405_respiratory_system_inflammati1.28566335
69MP0006036_abnormal_mitochondrial_physio1.27196874
70MP0003221_abnormal_cardiomyocyte_apopto1.23122250
71MP0003786_premature_aging1.22691098
72MP0004147_increased_porphyrin_level1.17865635
73MP0008932_abnormal_embryonic_tissue1.15620688
74MP0001533_abnormal_skeleton_physiology1.15557735
75MP0000685_abnormal_immune_system1.15401102
76MP0005666_abnormal_adipose_tissue1.15252719
77MP0005360_urolithiasis1.15107718
78MP0001986_abnormal_taste_sensitivity1.13885978
79MP0001873_stomach_inflammation1.11698842
80MP0000703_abnormal_thymus_morphology1.11646230
81MP0005670_abnormal_white_adipose1.10534275
82MP0003656_abnormal_erythrocyte_physiolo1.09312447
83MP0001663_abnormal_digestive_system1.07430674
84MP0003300_gastrointestinal_ulcer1.07327907
85MP0000313_abnormal_cell_death1.05198233
86MP0000350_abnormal_cell_proliferation1.04914972
87MP0004264_abnormal_extraembryonic_tissu1.03982084
88MP0008469_abnormal_protein_level1.01240824
89MP0005409_darkened_coat_color0.98455838
90MP0001764_abnormal_homeostasis0.98127207
91MP0010352_gastrointestinal_tract_polyps0.96242661
92MP0009765_abnormal_xenobiotic_induced0.96026570
93MP0000358_abnormal_cell_content/0.95995498
94MP0003075_altered_response_to0.94555595
95MP0006082_CNS_inflammation0.93707552
96MP0003828_pulmonary_edema0.93058656
97MP0003806_abnormal_nucleotide_metabolis0.91538338
98MP0002160_abnormal_reproductive_system0.88870479
99MP0004782_abnormal_surfactant_physiolog0.88281630
100MP0003252_abnormal_bile_duct0.87854880
101MP0002822_catalepsy0.87245752
102MP0001730_embryonic_growth_arrest0.86177160
103MP0009115_abnormal_fat_cell0.85011549
104MP0000598_abnormal_liver_morphology0.84168488
105MP0009764_decreased_sensitivity_to0.82642567
106MP0003123_paternal_imprinting0.82392573
107MP0003638_abnormal_response/metabolism_0.80993683
108MP0005058_abnormal_lysosome_morphology0.80181557
109MP0008260_abnormal_autophagy0.79886801
110MP0002970_abnormal_white_adipose0.79307098
111MP0001790_abnormal_immune_system0.78665648
112MP0005387_immune_system_phenotype0.78665648
113MP0000371_diluted_coat_color0.74668620
114MP0005334_abnormal_fat_pad0.72942152
115MP0002971_abnormal_brown_adipose0.71607154
116MP0001851_eye_inflammation0.70470484
117MP0008877_abnormal_DNA_methylation0.70245048
118MP0003191_abnormal_cellular_cholesterol0.69559398
119MP0005584_abnormal_enzyme/coenzyme_acti0.69109354
120MP0000681_abnormal_thyroid_gland0.67000029
121MP0002075_abnormal_coat/hair_pigmentati0.66253014
122* MP0008873_increased_physiological_sensi0.65940074
123* MP0009763_increased_sensitivity_to0.65389531
124MP0005375_adipose_tissue_phenotype0.65089315
125MP0003448_altered_tumor_morphology0.64039731
126MP0005384_cellular_phenotype0.63245273
127MP0002080_prenatal_lethality0.60872646
128MP0005319_abnormal_enzyme/_coenzyme0.59013974
129MP0006035_abnormal_mitochondrial_morpho0.58384272
130MP0001186_pigmentation_phenotype0.57627775
131MP0005381_digestive/alimentary_phenotyp0.54862126
132MP0002083_premature_death0.54489693

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)7.89290109
2Abnormal number of erythroid precursors (HP:0012131)4.89676776
3Abnormality of cells of the erythroid lineage (HP:0012130)4.63973219
4Elevated erythrocyte sedimentation rate (HP:0003565)4.47548663
5Abnormality of the prostate (HP:0008775)4.45675118
6Reduced antithrombin III activity (HP:0001976)4.37359060
7Aplastic anemia (HP:0001915)4.26822804
8Type I transferrin isoform profile (HP:0003642)4.11165240
9Obstructive lung disease (HP:0006536)4.08604640
10Chronic obstructive pulmonary disease (HP:0006510)4.08604640
11Acute lymphatic leukemia (HP:0006721)3.91243574
12Papilledema (HP:0001085)3.89400707
13Reticulocytopenia (HP:0001896)3.81851437
14Chest pain (HP:0100749)3.68920535
15Myositis (HP:0100614)3.62698088
16Recurrent abscess formation (HP:0002722)3.62065763
17Periodontitis (HP:0000704)3.54288025
18Recurrent bacterial skin infections (HP:0005406)3.51656284
19Agammaglobulinemia (HP:0004432)3.48405157
20Eosinophilia (HP:0001880)3.42473176
21Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.40044943
22Abnormal protein N-linked glycosylation (HP:0012347)3.40044943
23Abnormal protein glycosylation (HP:0012346)3.40044943
24Abnormal glycosylation (HP:0012345)3.40044943
25Granulocytopenia (HP:0001913)3.33048300
26Pulmonary fibrosis (HP:0002206)3.24067552
27Dysostosis multiplex (HP:0000943)3.16768254
28Abnormality of the heme biosynthetic pathway (HP:0010472)3.10336539
29Oral leukoplakia (HP:0002745)2.98123346
30Hepatosplenomegaly (HP:0001433)2.96190574
31Meningitis (HP:0001287)2.95549822
32IgM deficiency (HP:0002850)2.92139147
33Abnormality of T cell physiology (HP:0011840)2.84420904
34Ureteral stenosis (HP:0000071)2.84398205
35Petechiae (HP:0000967)2.81275830
36Amyloidosis (HP:0011034)2.75624390
37Chronic otitis media (HP:0000389)2.75075603
38Chromsome breakage (HP:0040012)2.69411266
39Spondylolisthesis (HP:0003302)2.67697503
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.62990717
41Abnormality of the pleura (HP:0002103)2.61223898
42Abnormality of B cell number (HP:0010975)2.58760724
43B lymphocytopenia (HP:0010976)2.58760724
44Microvesicular hepatic steatosis (HP:0001414)2.56297526
45Gangrene (HP:0100758)2.56284159
46Hemoptysis (HP:0002105)2.56171931
47Hypergammaglobulinemia (HP:0010702)2.55751517
48Pulmonary infiltrates (HP:0002113)2.54187820
49Eczematoid dermatitis (HP:0000976)2.53039663
5011 pairs of ribs (HP:0000878)2.51513591
51Neutropenia (HP:0001875)2.50921139
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.50399970
53Abnormality of the lumbar spine (HP:0100712)2.50072454
54Abnormality of eosinophils (HP:0001879)2.49123188
55Cellulitis (HP:0100658)2.48218949
56J-shaped sella turcica (HP:0002680)2.48132393
57Ureteral obstruction (HP:0006000)2.46196662
58Pulmonary embolism (HP:0002204)2.42381963
59Hypoplasia of the thymus (HP:0000778)2.41301521
60Recurrent cutaneous fungal infections (HP:0011370)2.40927946
61Chronic mucocutaneous candidiasis (HP:0002728)2.40927946
62Panhypogammaglobulinemia (HP:0003139)2.39805721
63Epistaxis (HP:0000421)2.39071481
64Hepatic necrosis (HP:0002605)2.37009243
65Agnosia (HP:0010524)2.36532759
66Prolonged bleeding time (HP:0003010)2.30008553
67Poikiloderma (HP:0001029)2.28939275
68Myelodysplasia (HP:0002863)2.28422785
69Pancytopenia (HP:0001876)2.28255307
70Mediastinal lymphadenopathy (HP:0100721)2.27717630
71Recurrent fungal infections (HP:0002841)2.27342267
72Bone marrow hypocellularity (HP:0005528)2.27027358
73Abnormality of the thoracic spine (HP:0100711)2.23702508
74Birth length less than 3rd percentile (HP:0003561)2.23613472
75Poor head control (HP:0002421)2.23318016
76Abnormality of glycolipid metabolism (HP:0010969)2.22113468
77Abnormality of liposaccharide metabolism (HP:0010968)2.22113468
78Abnormality of glycosphingolipid metabolism (HP:0004343)2.22113468
79Paresthesia (HP:0003401)2.21233127
80Spontaneous hematomas (HP:0007420)2.20558140
81Hypochromic microcytic anemia (HP:0004840)2.20521090
82Leukocytosis (HP:0001974)2.20091767
83Macrocytic anemia (HP:0001972)2.18158755
84Recurrent viral infections (HP:0004429)2.17916530
85Severe visual impairment (HP:0001141)2.16854284
86Generalized aminoaciduria (HP:0002909)2.15946991
87Fatigue (HP:0012378)2.15547134
88Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15130297
89Abnormality of male internal genitalia (HP:0000022)2.14451318
90Osteomyelitis (HP:0002754)2.14230675
91Amaurosis fugax (HP:0100576)2.12927848
92Recurrent skin infections (HP:0001581)2.11241870
93Increased serum ferritin (HP:0003281)2.10144217
94Vasculitis (HP:0002633)2.09980259
95Increased cerebral lipofuscin (HP:0011813)2.09643672
96Abnormal platelet function (HP:0011869)2.07115413
97Impaired platelet aggregation (HP:0003540)2.07115413
98Abnormality of chromosome stability (HP:0003220)2.07017382
99Stomatitis (HP:0010280)2.06218996
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04840829
101Hepatocellular necrosis (HP:0001404)2.02302908
102Thrombophlebitis (HP:0004418)2.01314615
103Abnormality of the anterior horn cell (HP:0006802)2.01276955
104Degeneration of anterior horn cells (HP:0002398)2.01276955
105Recurrent gram-negative bacterial infections (HP:0005420)2.00439227
106Skin ulcer (HP:0200042)1.98511140
107Skin rash (HP:0000988)1.98455193
108Abnormality of iron homeostasis (HP:0011031)1.97970115
109Orchitis (HP:0100796)1.97630522
110Acute myeloid leukemia (HP:0004808)1.97352325
111Premature graying of hair (HP:0002216)1.97325191
112Progressive muscle weakness (HP:0003323)1.97105804
113Thoracic kyphosis (HP:0002942)1.96791158
114Pallor (HP:0000980)1.94853912
115Autoimmune thrombocytopenia (HP:0001973)1.94782211
116Rhabdomyolysis (HP:0003201)1.93596912
117Abnormality of macrophages (HP:0004311)1.93494985
118Multiple enchondromatosis (HP:0005701)1.93208812
119Increased hepatocellular lipid droplets (HP:0006565)1.91697169
120Sepsis (HP:0100806)1.91444370
121Restrictive lung disease (HP:0002091)1.90927428
122Abnormality of the pericardium (HP:0001697)1.90699791
123Abnormality of the preputium (HP:0100587)1.90233382
124Lymphoma (HP:0002665)1.88513295
125Microcytic anemia (HP:0001935)1.88359031
126Lipid accumulation in hepatocytes (HP:0006561)1.88025900
127Urticaria (HP:0001025)1.85824620
128Arterial thrombosis (HP:0004420)1.85748305
129Abnormality of DNA repair (HP:0003254)1.82656243
130Glomerulopathy (HP:0100820)1.82317464
131Thickened calvaria (HP:0002684)1.81522379
132Increased serum lactate (HP:0002151)1.81465103
133Aplasia/Hypoplasia of the thymus (HP:0010515)1.81463794
134Exertional dyspnea (HP:0002875)1.81444848
135Albinism (HP:0001022)1.80173352
136Polyneuropathy (HP:0001271)1.79965345
137Vacuolated lymphocytes (HP:0001922)1.78101382
138Cutaneous melanoma (HP:0012056)1.78063998
139Increased muscle lipid content (HP:0009058)1.77824170
140Abdominal pain (HP:0002027)1.77775559
141Abnormality of cells of the lymphoid lineage (HP:0012140)1.77410070

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.90444735
2EIF2AK33.09366045
3IRAK42.98697097
4TEC2.89072013
5VRK22.77054811
6MAP3K122.72014087
7WEE12.71080903
8PIM22.53895482
9CDC72.51467217
10VRK12.32768368
11BUB12.27039362
12EIF2AK12.22259604
13TAOK32.18871512
14BTK2.15293296
15SCYL22.12925562
16TNK22.10828833
17CDK121.93493225
18MAP2K31.88090651
19CDK61.79048212
20BLK1.76073859
21KIT1.70528195
22ERN11.66258019
23FES1.63058261
24DAPK11.56371392
25TSSK61.55381356
26SRPK11.54847964
27NUAK11.54574295
28SMG11.54473964
29EEF2K1.53925141
30MAP3K61.53142949
31FLT31.48661414
32TESK11.47621586
33TESK21.46176004
34ICK1.41995798
35ATR1.37214188
36CAMK1D1.36858374
37PRPF4B1.36564087
38BRSK21.33985849
39CDK71.33939839
40MAP4K11.30508855
41CLK11.27699672
42CDK81.25741088
43TNIK1.24285678
44PAK41.17730809
45ABL21.16977130
46BMPR21.15043597
47ITK1.11923746
48RPS6KB21.10596442
49MKNK11.10345697
50HIPK21.08999463
51PASK1.08736101
52MYLK1.08661996
53TBK11.08335957
54SYK1.06453528
55NEK21.04303230
56NME21.03335092
57ZAP700.98501961
58PKN20.95109730
59HCK0.92214606
60BRD40.91440112
61AURKB0.89702143
62ACVR1B0.88863979
63CDK190.88682423
64EIF2AK20.87567605
65IRAK30.86435641
66PLK40.85565262
67RPS6KC10.84255360
68RPS6KL10.84255360
69MAPK40.83056399
70RPS6KA60.80784155
71TRIB30.80682714
72RAF10.80391280
73TLK10.80064942
74RPS6KB10.79546036
75MAP3K80.78997170
76NEK10.78573184
77TGFBR10.78028902
78CAMK1G0.77497862
79CDK40.77488320
80PLK10.77184233
81MATK0.77056408
82LIMK10.76415475
83IKBKB0.75495777
84CCNB10.74594028
85LYN0.73663289
86DYRK30.72343273
87TYK20.70591500
88MKNK20.70052185
89PIM10.69108597
90BCKDK0.69017234
91BRSK10.67534600
92KDR0.66793471
93LCK0.66079709
94ILK0.65629728
95LRRK20.64710653
96MAPKAPK30.63788996
97CAMKK20.63650029
98TTK0.63454355
99RPS6KA20.62622792
100MAPK110.62211511
101IKBKE0.61027291
102STK40.60768391
103RPS6KA40.60033375
104TRPM70.58523689
105GRK70.58129085
106PIK3CG0.57412435
107RIPK40.55750442
108MAP3K140.55559133
109MAPKAPK50.54909579
110CSF1R0.54415604
111PLK30.53073850
112CSNK2A20.49600410
113GRK60.49560212
114TXK0.47684770
115CHEK20.47441090
116CSNK2A10.47182434
117PAK10.46859817
118CHEK10.44496105
119PAK20.43948492
120STK100.43214883
121MAP3K110.43078318
122ZAK0.42945159
123MAP2K60.41850255
124MAP3K100.39556088
125MAP2K20.39437237
126CDK20.38972529
127TAOK20.37150761
128MTOR0.37108880
129RET0.37108327
130JAK30.36432285
131TAF10.35497377
132JAK20.33710022
133MAP2K40.33663728
134CDK30.33304519
135PRKAA20.33299343
136MARK20.32773269
137CDK90.31830261
138MAPK30.31799673

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.57778498
2Mismatch repair_Homo sapiens_hsa034303.85310544
3Ribosome_Homo sapiens_hsa030103.41024590
4Protein export_Homo sapiens_hsa030603.18245715
5Base excision repair_Homo sapiens_hsa034103.14399412
6Homologous recombination_Homo sapiens_hsa034403.09116840
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.64011194
8N-Glycan biosynthesis_Homo sapiens_hsa005102.44452495
9Proteasome_Homo sapiens_hsa030502.29503996
10Nucleotide excision repair_Homo sapiens_hsa034202.26465206
11Spliceosome_Homo sapiens_hsa030402.18559237
12Pentose phosphate pathway_Homo sapiens_hsa000302.15349589
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11505880
14Renin-angiotensin system_Homo sapiens_hsa046142.03884542
15Non-homologous end-joining_Homo sapiens_hsa034502.03001135
16Pyrimidine metabolism_Homo sapiens_hsa002401.98416205
17Acute myeloid leukemia_Homo sapiens_hsa052211.97078419
18One carbon pool by folate_Homo sapiens_hsa006701.90855362
19Fanconi anemia pathway_Homo sapiens_hsa034601.79523829
20RNA polymerase_Homo sapiens_hsa030201.70658167
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.63295043
22Cell cycle_Homo sapiens_hsa041101.62789214
23RNA transport_Homo sapiens_hsa030131.55587330
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53669654
25Other glycan degradation_Homo sapiens_hsa005111.46513270
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41459160
27Galactose metabolism_Homo sapiens_hsa000521.37031628
28RNA degradation_Homo sapiens_hsa030181.32797451
29Antigen processing and presentation_Homo sapiens_hsa046121.32305663
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.29244285
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22863873
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21868859
33Glutathione metabolism_Homo sapiens_hsa004801.18712224
34Leishmaniasis_Homo sapiens_hsa051401.13191110
35Systemic lupus erythematosus_Homo sapiens_hsa053221.12991470
36Purine metabolism_Homo sapiens_hsa002301.11877001
37Hematopoietic cell lineage_Homo sapiens_hsa046401.10867317
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10391318
39Malaria_Homo sapiens_hsa051441.09539594
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01814933
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.00654814
42Amoebiasis_Homo sapiens_hsa051460.98475345
43Asthma_Homo sapiens_hsa053100.98344089
44Platelet activation_Homo sapiens_hsa046110.98280421
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97927312
46Staphylococcus aureus infection_Homo sapiens_hsa051500.97887799
47Non-small cell lung cancer_Homo sapiens_hsa052230.97875746
48Sulfur relay system_Homo sapiens_hsa041220.96630973
49Chronic myeloid leukemia_Homo sapiens_hsa052200.92645991
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.86862002
51Biosynthesis of amino acids_Homo sapiens_hsa012300.86255269
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85579195
53Pancreatic cancer_Homo sapiens_hsa052120.85508044
54Herpes simplex infection_Homo sapiens_hsa051680.85262495
55Legionellosis_Homo sapiens_hsa051340.84787919
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84144566
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83394582
58Starch and sucrose metabolism_Homo sapiens_hsa005000.82211411
59Carbon metabolism_Homo sapiens_hsa012000.80505925
60African trypanosomiasis_Homo sapiens_hsa051430.78017478
61p53 signaling pathway_Homo sapiens_hsa041150.76934297
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74994613
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74356396
64Basal transcription factors_Homo sapiens_hsa030220.71820419
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71628684
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70974155
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.69473066
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67653239
69Primary immunodeficiency_Homo sapiens_hsa053400.66997529
70Lysosome_Homo sapiens_hsa041420.63419315
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60376317
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60118934
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56976685
74Fructose and mannose metabolism_Homo sapiens_hsa000510.56589025
75Pertussis_Homo sapiens_hsa051330.56556812
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55725563
77Epstein-Barr virus infection_Homo sapiens_hsa051690.54840290
78Thyroid cancer_Homo sapiens_hsa052160.54469453
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53652909
80Parkinsons disease_Homo sapiens_hsa050120.52549842
81Selenocompound metabolism_Homo sapiens_hsa004500.51413811
82Folate biosynthesis_Homo sapiens_hsa007900.50837098
83Measles_Homo sapiens_hsa051620.50219028
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49745973
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.46905342
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.46380138
87Lysine degradation_Homo sapiens_hsa003100.45718423
88mRNA surveillance pathway_Homo sapiens_hsa030150.43768741
89VEGF signaling pathway_Homo sapiens_hsa043700.43689876
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43322479
91Apoptosis_Homo sapiens_hsa042100.41711270
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41316521
93Metabolic pathways_Homo sapiens_hsa011000.41072485
94HTLV-I infection_Homo sapiens_hsa051660.40391533
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39823822
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38917835
97T cell receptor signaling pathway_Homo sapiens_hsa046600.38419383
98Peroxisome_Homo sapiens_hsa041460.36962555
99Huntingtons disease_Homo sapiens_hsa050160.36709701
100Influenza A_Homo sapiens_hsa051640.35531011
101Oxidative phosphorylation_Homo sapiens_hsa001900.34900650
102Glycerolipid metabolism_Homo sapiens_hsa005610.34862183
103Osteoclast differentiation_Homo sapiens_hsa043800.34304100
104* Phagosome_Homo sapiens_hsa041450.33936676
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.33564066
106Viral carcinogenesis_Homo sapiens_hsa052030.32103492
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31468770
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31030092
109B cell receptor signaling pathway_Homo sapiens_hsa046620.30746655
110Hepatitis B_Homo sapiens_hsa051610.30669756
111Tuberculosis_Homo sapiens_hsa051520.30635935
112Sulfur metabolism_Homo sapiens_hsa009200.30240718
113Histidine metabolism_Homo sapiens_hsa003400.30237404
114Shigellosis_Homo sapiens_hsa051310.29817991
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29622787
116mTOR signaling pathway_Homo sapiens_hsa041500.29549184
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28971078
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27674084
119* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26947423
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26406315
121Salmonella infection_Homo sapiens_hsa051320.25306033
122Arachidonic acid metabolism_Homo sapiens_hsa005900.25263102
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.24662390
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24528057
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24293008
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24244227
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23205015
128Ether lipid metabolism_Homo sapiens_hsa005650.22383726

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