MPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.37504291
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.08587543
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.08587543
4modulation by symbiont of host immune response (GO:0052553)5.08587543
5positive regulation by symbiont of host defense response (GO:0052509)5.08587543
6modulation by symbiont of host defense response (GO:0052031)5.08587543
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.08587543
8neutrophil activation involved in immune response (GO:0002283)4.87408279
9regulation of interferon-beta biosynthetic process (GO:0045357)4.84498693
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.49363982
11positive regulation of interferon-alpha production (GO:0032727)4.39114209
12low-density lipoprotein particle clearance (GO:0034383)4.15244273
13regulation of interferon-alpha production (GO:0032647)4.14308529
14positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.08372719
15cellular response to thyroid hormone stimulus (GO:0097067)4.00357572
16oxygen transport (GO:0015671)3.93060760
17macrophage activation involved in immune response (GO:0002281)3.88514906
18response to peptidoglycan (GO:0032494)3.77269452
19immunoglobulin mediated immune response (GO:0016064)3.64555114
20gas transport (GO:0015669)3.60156195
21regulation of gamma-delta T cell activation (GO:0046643)3.59541673
22negative regulation of cell killing (GO:0031342)3.58019890
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.58019890
24respiratory burst (GO:0045730)3.58018981
25positive regulation of mast cell activation involved in immune response (GO:0033008)3.57212882
26positive regulation of mast cell degranulation (GO:0043306)3.57212882
27regulation of platelet aggregation (GO:0090330)3.56319859
28regulation of cholesterol storage (GO:0010885)3.49704685
29regulation of myeloid leukocyte mediated immunity (GO:0002886)3.48592795
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.48471546
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.48471546
32detection of other organism (GO:0098543)3.41329313
33leukocyte degranulation (GO:0043299)3.40426506
34megakaryocyte development (GO:0035855)3.38065897
35response to host immune response (GO:0052572)3.37204619
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.37204619
37positive regulation of granulocyte differentiation (GO:0030854)3.33285346
38protoporphyrinogen IX biosynthetic process (GO:0006782)3.28612384
39myeloid cell development (GO:0061515)3.27819874
40regulation of gamma-delta T cell differentiation (GO:0045586)3.27164960
41regulation of platelet activation (GO:0010543)3.26808000
42positive regulation of cellular amide metabolic process (GO:0034250)3.25648093
43erythrocyte development (GO:0048821)3.24905776
44pinocytosis (GO:0006907)3.19196558
45detection of bacterium (GO:0016045)3.12616142
46detection of external biotic stimulus (GO:0098581)3.10810979
47antigen processing and presentation of endogenous antigen (GO:0019883)3.10650128
48granulocyte activation (GO:0036230)3.08178171
49positive regulation of interferon-beta production (GO:0032728)3.07885379
50definitive hemopoiesis (GO:0060216)3.07407388
51regulation of erythrocyte differentiation (GO:0045646)3.05369272
52positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05221246
53response to host defenses (GO:0052200)3.02147369
54response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.02147369
55response to host (GO:0075136)3.02147369
56production of molecular mediator involved in inflammatory response (GO:0002532)3.01088741
57negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.01079834
58Arp2/3 complex-mediated actin nucleation (GO:0034314)3.00393250
59natural killer cell mediated cytotoxicity (GO:0042267)2.96873152
60natural killer cell mediated immunity (GO:0002228)2.96873152
61myeloid cell activation involved in immune response (GO:0002275)2.94585787
62lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94111910
63neutrophil activation (GO:0042119)2.94005871
64erythrocyte maturation (GO:0043249)2.92007564
65B cell receptor signaling pathway (GO:0050853)2.91208492
66regulation of mononuclear cell migration (GO:0071675)2.91079708
67apoptotic cell clearance (GO:0043277)2.89963824
68positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.88659600
69negative regulation of phagocytosis (GO:0050765)2.87230021
70leukocyte migration involved in inflammatory response (GO:0002523)2.86371619
71pentose-phosphate shunt (GO:0006098)2.86341767
72angiotensin maturation (GO:0002003)2.84180564
73thrombin receptor signaling pathway (GO:0070493)2.83521723
74positive regulation of chemokine biosynthetic process (GO:0045080)2.80580639
75regulation of regulated secretory pathway (GO:1903305)2.80068320
76B cell mediated immunity (GO:0019724)2.79558281
77lipoprotein transport (GO:0042953)2.78997521
78regulation of B cell receptor signaling pathway (GO:0050855)2.78904682
79regulation of B cell differentiation (GO:0045577)2.78815074
80response to interferon-alpha (GO:0035455)2.78396764
81N-acetylneuraminate metabolic process (GO:0006054)2.77853067
82adenosine receptor signaling pathway (GO:0001973)2.77353933
83positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.74798273
84positive regulation of gamma-delta T cell activation (GO:0046645)2.73806662
85NADPH regeneration (GO:0006740)2.73259992
86hydrogen peroxide biosynthetic process (GO:0050665)2.71858959
87germinal center formation (GO:0002467)2.71810846
88histamine secretion (GO:0001821)2.70168831
89regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.69970694
90response to type I interferon (GO:0034340)2.69857479
91cellular extravasation (GO:0045123)2.69471968
92hemoglobin metabolic process (GO:0020027)2.68079294
93JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.66475815
94detection of biotic stimulus (GO:0009595)2.65699633
95type I interferon signaling pathway (GO:0060337)2.64561192
96cellular response to type I interferon (GO:0071357)2.64561192
97granulocyte differentiation (GO:0030851)2.64102423
98regulation of granulocyte differentiation (GO:0030852)2.63703329
99negative regulation of lipid storage (GO:0010888)2.62891913
100reactive oxygen species biosynthetic process (GO:1903409)2.62891682
101regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.62590438
102cellular response to interferon-alpha (GO:0035457)2.61918681
103regulation of interleukin-8 biosynthetic process (GO:0045414)2.61457939
104regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.60637385
105protoporphyrinogen IX metabolic process (GO:0046501)2.59631098
106positive regulation of B cell differentiation (GO:0045579)2.58996789
107glycosphingolipid catabolic process (GO:0046479)2.58642167
108negative regulation of interleukin-12 production (GO:0032695)2.57424164
109autophagic vacuole fusion (GO:0000046)2.55592559
110leukocyte cell-cell adhesion (GO:0007159)2.55093005
111macrophage activation (GO:0042116)2.54622212
112response to fungus (GO:0009620)2.54420939
113detection of molecule of bacterial origin (GO:0032490)2.53803502
114microglial cell activation (GO:0001774)2.53134457
115negative regulation of interleukin-17 production (GO:0032700)2.52904852
116platelet formation (GO:0030220)2.52721072
117myeloid leukocyte activation (GO:0002274)2.50528317
118plasma lipoprotein particle clearance (GO:0034381)2.48900053
119negative regulation of T cell mediated immunity (GO:0002710)2.47715869
120regulation of interferon-beta production (GO:0032648)2.47597201
121positive regulation of regulated secretory pathway (GO:1903307)2.47162658
122actin filament polymerization (GO:0030041)2.46882739
123positive regulation of reactive oxygen species metabolic process (GO:2000379)2.46513130
124positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.46413338
125positive thymic T cell selection (GO:0045059)2.46405396
126regulation of mast cell degranulation (GO:0043304)2.46265129
127neutrophil mediated immunity (GO:0002446)2.45365180
128leukocyte mediated cytotoxicity (GO:0001909)2.44761416
129positive regulation of antigen processing and presentation (GO:0002579)2.44176735
130I-kappaB phosphorylation (GO:0007252)2.42885515
131actin nucleation (GO:0045010)2.40738494
132hepatocyte apoptotic process (GO:0097284)2.39371890
133regulation of macrophage chemotaxis (GO:0010758)2.38925466
134response to thyroid hormone (GO:0097066)2.38610911
135regulation of mast cell activation (GO:0033003)2.37601375
136cell adhesion mediated by integrin (GO:0033627)2.37512302
137regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.34404398
138myeloid cell homeostasis (GO:0002262)2.34248974
139response to muramyl dipeptide (GO:0032495)2.31372786
140cellular response to virus (GO:0098586)2.31353087
141regulation of chemokine biosynthetic process (GO:0045073)2.31306382
142regulation of mast cell activation involved in immune response (GO:0033006)2.30931147
143leukotriene metabolic process (GO:0006691)2.30711026
144negative regulation of mast cell activation (GO:0033004)2.30368103
145positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.30024708
146protein-lipid complex assembly (GO:0065005)2.29429357
147regulation of leukocyte degranulation (GO:0043300)2.28919268
148positive regulation of mast cell activation (GO:0033005)2.28616264
149leukocyte aggregation (GO:0070486)2.28447069
150positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.28064710
151positive regulation of leukocyte degranulation (GO:0043302)2.27376814
152positive regulation of natural killer cell differentiation (GO:0032825)2.25413385
153positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.24586879

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.77032052
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.66835705
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.77525363
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.15722604
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13892983
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01593545
7* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.93316902
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.87575591
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.83484124
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.72000039
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.71404861
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.70859116
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.59130845
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.51943842
15E2F7_22180533_ChIP-Seq_HELA_Human2.42194623
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34292446
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.28704114
18SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.25982586
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.23906451
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.20322500
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.18867511
22GATA1_22025678_ChIP-Seq_K562_Human2.13814889
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.11142968
24* NCOR1_26117541_ChIP-Seq_K562_Human2.10877984
25* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.04430783
26TP63_17297297_ChIP-ChIP_HaCaT_Human2.03590893
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02866162
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93509160
29GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.92314555
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92099775
31SPI1_23547873_ChIP-Seq_NB4_Human1.87431825
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.81515739
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76228112
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74411548
35VDR_21846776_ChIP-Seq_THP-1_Human1.73214496
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.71168244
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70462615
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.70136516
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67881630
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65919730
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.65632924
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.63933652
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61616138
44VDR_24763502_ChIP-Seq_THP-1_Human1.60793096
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.59325980
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55317892
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.54790184
48MAF_26560356_Chip-Seq_TH1_Human1.52895945
49SCL_19346495_ChIP-Seq_HPC-7_Human1.51557958
50CLOCK_20551151_ChIP-Seq_293T_Human1.50327179
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.49763307
52TCF7_22412390_ChIP-Seq_EML_Mouse1.49629387
53* MYB_26560356_Chip-Seq_TH2_Human1.41778600
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41518993
55SPI1_23127762_ChIP-Seq_K562_Human1.41351987
56TFEB_21752829_ChIP-Seq_HELA_Human1.39949859
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38368722
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36251736
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35731507
60PU_27001747_Chip-Seq_BMDM_Mouse1.34876592
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34011517
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.33149387
63MAF_26560356_Chip-Seq_TH2_Human1.32778877
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32365079
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31771701
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30634660
67* ELK3_25401928_ChIP-Seq_HUVEC_Human1.30599079
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30197045
69GATA3_27048872_Chip-Seq_THYMUS_Human1.29553029
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29289078
71GATA1_19941826_ChIP-Seq_K562_Human1.28605475
72MYB_26560356_Chip-Seq_TH1_Human1.28528847
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27898281
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24755257
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23729197
76* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22404641
77UTX_26944678_Chip-Seq_JUKART_Human1.22342715
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.19506750
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18217060
80MYC_22102868_ChIP-Seq_BL_Human1.16667889
81KDM2B_26808549_Chip-Seq_DND41_Human1.15929815
82* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15617574
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13345318
84KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.12706689
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11790239
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11214650
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10172622
88GATA2_19941826_ChIP-Seq_K562_Human1.09969545
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09202492
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08577781
91KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08017755
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07772739
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07759046
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04702851
95GATA2_21666600_ChIP-Seq_HMVEC_Human1.04170363
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04045609
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03000768
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02529739
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02180916
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01804056
101ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01536023
102FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00653411
103CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00338675
104RUNX_20019798_ChIP-Seq_JUKART_Human0.99986039
105ELF1_20517297_ChIP-Seq_JURKAT_Human0.99862180
106GATA3_26560356_Chip-Seq_TH2_Human0.99546977
107AR_21909140_ChIP-Seq_LNCAP_Human0.99128139
108RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99070455
109ETS1_22383799_ChIP-Seq_G1ME_Mouse0.98895011
110VDR_24787735_ChIP-Seq_THP-1_Human0.98679350
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97627842
112BCL6_27268052_Chip-Seq_Bcells_Human0.96896856
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96881301
114BCOR_27268052_Chip-Seq_Bcells_Human0.96866680
115SPI1_20517297_ChIP-Seq_HL60_Human0.96070141
116GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94786297
117STAT1_20625510_ChIP-Seq_HELA_Human0.94709664
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92728435
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92303653
120ATF3_27146783_Chip-Seq_COLON_Human0.91251054
121STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90626981
122SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90363062
123GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89578252
124SOX2_20726797_ChIP-Seq_SW620_Human0.89423008
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88972051
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88685526
127PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88654151
128GATA4_25053715_ChIP-Seq_YYC3_Human0.88225427
129CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88148528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.37646204
2MP0003436_decreased_susceptibility_to3.02239349
3MP0005360_urolithiasis2.90039627
4MP0001835_abnormal_antigen_presentation2.79261131
5MP0003303_peritoneal_inflammation2.67971993
6MP0003656_abnormal_erythrocyte_physiolo2.59686060
7MP0009840_abnormal_foam_cell2.59330610
8MP0003724_increased_susceptibility_to2.53237760
9MP0009785_altered_susceptibility_to2.47545696
10MP0003191_abnormal_cellular_cholesterol2.44350350
11* MP0002419_abnormal_innate_immunity2.34815796
12MP0008438_abnormal_cutaneous_collagen2.32084537
13MP0005451_abnormal_body_composition2.24617576
14MP0006082_CNS_inflammation2.16827411
15MP0002148_abnormal_hypersensitivity_rea2.12069961
16MP0005000_abnormal_immune_tolerance2.11116199
17MP0005025_abnormal_response_to2.10956303
18MP0008004_abnormal_stomach_pH2.09616364
19MP0003300_gastrointestinal_ulcer2.06168256
20MP0005464_abnormal_platelet_physiology2.00771281
21MP0008260_abnormal_autophagy1.97611005
22MP0003705_abnormal_hypodermis_morpholog1.89496816
23MP0002452_abnormal_antigen_presenting1.88412126
24MP0001533_abnormal_skeleton_physiology1.87904075
25MP0003172_abnormal_lysosome_physiology1.81485123
26MP0000685_abnormal_immune_system1.78138624
27MP0005387_immune_system_phenotype1.74751481
28MP0001790_abnormal_immune_system1.74751481
29MP0010307_abnormal_tumor_latency1.73647010
30MP0010352_gastrointestinal_tract_polyps1.73530209
31MP0001800_abnormal_humoral_immune1.72694844
32MP0002132_abnormal_respiratory_system1.71587770
33MP0004947_skin_inflammation1.70237212
34MP0003186_abnormal_redox_activity1.66809631
35MP0002723_abnormal_immune_serum1.66775358
36MP0004147_increased_porphyrin_level1.65683928
37MP0003806_abnormal_nucleotide_metabolis1.64655021
38MP0005397_hematopoietic_system_phenotyp1.63913153
39MP0001545_abnormal_hematopoietic_system1.63913153
40MP0000343_altered_response_to1.60971468
41* MP0001819_abnormal_immune_cell1.57050732
42MP0001845_abnormal_inflammatory_respons1.56039700
43* MP0002420_abnormal_adaptive_immunity1.55829719
44MP0009764_decreased_sensitivity_to1.51291385
45MP0002405_respiratory_system_inflammati1.49748257
46MP0003448_altered_tumor_morphology1.48493168
47MP0004510_myositis1.47878389
48MP0000858_altered_metastatic_potential1.47143943
49MP0008469_abnormal_protein_level1.46867275
50MP0002166_altered_tumor_susceptibility1.44041993
51MP0001958_emphysema1.40238468
52MP0005671_abnormal_response_to1.39344879
53MP0010155_abnormal_intestine_physiology1.37573537
54MP0009333_abnormal_splenocyte_physiolog1.35934321
55MP0009278_abnormal_bone_marrow1.35882182
56MP0003566_abnormal_cell_adhesion1.32660698
57MP0000604_amyloidosis1.30989239
58MP0006054_spinal_hemorrhage1.29919215
59MP0003075_altered_response_to1.29903514
60MP0002139_abnormal_hepatobiliary_system1.28616265
61MP0001853_heart_inflammation1.28421448
62MP0010329_abnormal_lipoprotein_level1.26819229
63MP0002006_tumorigenesis1.26252325
64MP0000689_abnormal_spleen_morphology1.25957470
65MP0005023_abnormal_wound_healing1.23941780
66MP0002398_abnormal_bone_marrow1.23669215
67MP0000716_abnormal_immune_system1.21031826
68MP0000490_abnormal_crypts_of1.18107957
69MP0003763_abnormal_thymus_physiology1.14739077
70MP0002722_abnormal_immune_system1.14000416
71MP0002429_abnormal_blood_cell1.12487516
72MP0002136_abnormal_kidney_physiology1.12387434
73MP0009643_abnormal_urine_homeostasis1.10993500
74MP0000703_abnormal_thymus_morphology1.10942417
75MP0000609_abnormal_liver_physiology1.09249581
76MP0005164_abnormal_response_to1.08035497
77MP0002998_abnormal_bone_remodeling1.06806199
78MP0003183_abnormal_peptide_metabolism1.03813735
79MP0000015_abnormal_ear_pigmentation1.02537923
80MP0002396_abnormal_hematopoietic_system1.02101061
81MP0009763_increased_sensitivity_to1.01178310
82MP0004019_abnormal_vitamin_homeostasis1.00941859
83MP0001666_abnormal_nutrient_absorption0.99154478
84MP0005166_decreased_susceptibility_to0.98359872
85MP0004883_abnormal_blood_vessel0.98314366
86MP0005275_abnormal_skin_tensile0.96968298
87MP0005319_abnormal_enzyme/_coenzyme0.92583193
88MP0009765_abnormal_xenobiotic_induced0.92202933
89MP0009115_abnormal_fat_cell0.90780818
90MP0001851_eye_inflammation0.90335020
91MP0002933_joint_inflammation0.90089038
92MP0005083_abnormal_biliary_tract0.88952722
93MP0005167_abnormal_blood-brain_barrier0.88754522
94MP0006036_abnormal_mitochondrial_physio0.87942943
95MP0005076_abnormal_cell_differentiation0.87725085
96MP0005670_abnormal_white_adipose0.87608892
97MP0005332_abnormal_amino_acid0.87508026
98MP0005390_skeleton_phenotype0.86501328
99MP0003866_abnormal_defecation0.86489334
100MP0003453_abnormal_keratinocyte_physiol0.86124586
101MP0001663_abnormal_digestive_system0.85397704
102MP0005310_abnormal_salivary_gland0.84526679
103MP0000598_abnormal_liver_morphology0.84469777
104MP0005584_abnormal_enzyme/coenzyme_acti0.84199832
105MP0008875_abnormal_xenobiotic_pharmacok0.83486360
106MP0001756_abnormal_urination0.82490011
107MP0000569_abnormal_digit_pigmentation0.82239881
108MP0003690_abnormal_glial_cell0.81737052
109MP0000249_abnormal_blood_vessel0.81537307
110MP0003828_pulmonary_edema0.81191027
111MP0000465_gastrointestinal_hemorrhage0.79367657
112MP0002332_abnormal_exercise_endurance0.78707415
113MP0005535_abnormal_body_temperature0.78704684
114MP0002138_abnormal_hepatobiliary_system0.77924210
115MP0004130_abnormal_muscle_cell0.77588208
116MP0004808_abnormal_hematopoietic_stem0.77325257
117MP0008874_decreased_physiological_sensi0.76615880
118MP0003252_abnormal_bile_duct0.75170512
119MP0002019_abnormal_tumor_incidence0.69444184
120MP0002877_abnormal_melanocyte_morpholog0.68534491
121MP0005636_abnormal_mineral_homeostasis0.68484706
122MP0003795_abnormal_bone_structure0.62620724
123MP0008995_early_reproductive_senescence0.59684658
124MP0005165_increased_susceptibility_to0.58778993
125MP0003221_abnormal_cardiomyocyte_apopto0.54676150
126MP0005075_abnormal_melanosome_morpholog0.53415318

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)5.67266208
2Recurrent abscess formation (HP:0002722)5.36434024
3Abnormality of the heme biosynthetic pathway (HP:0010472)5.35284709
4Vacuolated lymphocytes (HP:0001922)4.99152197
5Eczematoid dermatitis (HP:0000976)4.94603976
6Autoimmune thrombocytopenia (HP:0001973)4.79468460
7Recurrent bacterial skin infections (HP:0005406)4.66768987
8Increased cerebral lipofuscin (HP:0011813)4.50171809
9Recurrent gram-negative bacterial infections (HP:0005420)4.43588396
10Abnormality of macrophages (HP:0004311)4.28748401
11Increased neuronal autofluorescent lipopigment (HP:0002074)4.04689353
12Systemic lupus erythematosus (HP:0002725)4.02166553
13Polycythemia (HP:0001901)3.81032780
14Axonal loss (HP:0003447)3.45383900
15Abnormal gallbladder physiology (HP:0012438)3.35363930
16Cholecystitis (HP:0001082)3.35363930
17Pustule (HP:0200039)3.31246399
18Dysostosis multiplex (HP:0000943)3.29495690
19Menorrhagia (HP:0000132)3.26097285
20Gingivitis (HP:0000230)3.08219048
21Elevated erythrocyte sedimentation rate (HP:0003565)3.06074026
22Hypochromic microcytic anemia (HP:0004840)2.94860952
23Retrobulbar optic neuritis (HP:0100654)2.88241434
24Optic neuritis (HP:0100653)2.88241434
25Nausea (HP:0002018)2.86420281
26Petechiae (HP:0000967)2.82875897
27Recurrent fungal infections (HP:0002841)2.82026259
28Myositis (HP:0100614)2.81801908
29Disinhibition (HP:0000734)2.81192262
30Interstitial pulmonary disease (HP:0006530)2.80655481
31Urinary glycosaminoglycan excretion (HP:0003541)2.78258784
32Mucopolysacchariduria (HP:0008155)2.78258784
33Recurrent skin infections (HP:0001581)2.76760937
34Cellulitis (HP:0100658)2.75643529
35Microcytic anemia (HP:0001935)2.73737303
36Myocardial infarction (HP:0001658)2.70370506
37Prostate neoplasm (HP:0100787)2.68785998
38Recurrent viral infections (HP:0004429)2.67548230
39Paralysis (HP:0003470)2.67511111
40Obstructive lung disease (HP:0006536)2.64734061
41Chronic obstructive pulmonary disease (HP:0006510)2.64734061
42Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.62910418
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.62877263
44Osteolytic defects of the hand bones (HP:0009699)2.62877263
45Encephalitis (HP:0002383)2.61943495
46Abnormality of glutamine family amino acid metabolism (HP:0010902)2.61845531
47Cholelithiasis (HP:0001081)2.59527393
48Hypertensive crisis (HP:0100735)2.58877966
49Urticaria (HP:0001025)2.56451199
50Mediastinal lymphadenopathy (HP:0100721)2.56449794
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56276208
52Abnormality of polysaccharide metabolism (HP:0011012)2.56276208
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56276208
54Meningitis (HP:0001287)2.53788003
55Abnormality of liposaccharide metabolism (HP:0010968)2.53034089
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.53034089
57Abnormality of glycolipid metabolism (HP:0010969)2.53034089
58Osteomyelitis (HP:0002754)2.51401261
59Poikilocytosis (HP:0004447)2.47384416
60Tetraparesis (HP:0002273)2.45698972
61Abnormal hemoglobin (HP:0011902)2.44331231
62Orchitis (HP:0100796)2.40966589
63Vertebral compression fractures (HP:0002953)2.39691877
64Gastrointestinal infarctions (HP:0005244)2.38912397
65Arterial thrombosis (HP:0004420)2.38299380
66Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.37374498
67Increased serum ferritin (HP:0003281)2.37015267
68Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.35896353
69Autoimmune hemolytic anemia (HP:0001890)2.34062378
70Glomerulonephritis (HP:0000099)2.33011027
71Pathologic fracture (HP:0002756)2.32666003
72Hydroxyprolinuria (HP:0003080)2.31733554
73Abnormality of proline metabolism (HP:0010907)2.31733554
74Cervical subluxation (HP:0003308)2.28556619
75Periodontitis (HP:0000704)2.28067492
76Abnormal gallbladder morphology (HP:0012437)2.27637785
77Keratoconjunctivitis sicca (HP:0001097)2.25354979
78Abnormal delayed hypersensitivity skin test (HP:0002963)2.25059421
79Spontaneous hematomas (HP:0007420)2.24526856
80Loss of speech (HP:0002371)2.22969814
81T lymphocytopenia (HP:0005403)2.22156465
82Inflammation of the large intestine (HP:0002037)2.21156217
83Basal ganglia calcification (HP:0002135)2.18432301
84Hematochezia (HP:0002573)2.18147324
85Episodic fever (HP:0001954)2.17979572
86Increased IgM level (HP:0003496)2.17742308
87Abnormality of iron homeostasis (HP:0011031)2.16740384
88Peritonitis (HP:0002586)2.16724006
89Nephritis (HP:0000123)2.16422005
90Hypochromic anemia (HP:0001931)2.16143902
91Acanthocytosis (HP:0001927)2.15518353
92Gastrointestinal inflammation (HP:0004386)2.14633480
93Xanthomatosis (HP:0000991)2.13931429
94Conjunctival telangiectasia (HP:0000524)2.13888545
95Purpura (HP:0000979)2.11893789
96Panhypogammaglobulinemia (HP:0003139)2.11542209
97Agnosia (HP:0010524)2.10300635
98Abnormality of T cell number (HP:0011839)2.10165273
99Abnormality of complement system (HP:0005339)2.08114293
100Reticulocytosis (HP:0001923)2.05367011
101Vasculitis (HP:0002633)2.04488326
102Hepatosplenomegaly (HP:0001433)2.04454914
103Chest pain (HP:0100749)2.04409003
104Leukocytosis (HP:0001974)2.03754791
105Premature rupture of membranes (HP:0001788)2.02962922
106Ileus (HP:0002595)2.02047801
107Stomatitis (HP:0010280)2.01438427
108Colitis (HP:0002583)2.00986902
109Hyperthyroidism (HP:0000836)2.00448096
110Thrombocytosis (HP:0001894)1.99672752
111Keratoconjunctivitis (HP:0001096)1.99500091
112Recurrent cutaneous fungal infections (HP:0011370)1.98605462
113Chronic mucocutaneous candidiasis (HP:0002728)1.98605462
114Impaired platelet aggregation (HP:0003540)1.97286595
115Abnormal platelet function (HP:0011869)1.97286595
116Abnormality of the vasculature of the conjunctiva (HP:0008054)1.96931776
117Increased IgE level (HP:0003212)1.96542440
118Hypertriglyceridemia (HP:0002155)1.96510544
119Vertigo (HP:0002321)1.96068943
120Abnormality of reticulocytes (HP:0004312)1.95716276
121Anorexia (HP:0002039)1.95322014
122Abnormality of T cells (HP:0002843)1.95089775
123Eosinophilia (HP:0001880)1.94386233
124Complement deficiency (HP:0004431)1.94194788
125Abnormality of transition element cation homeostasis (HP:0011030)1.93989225
126Slow saccadic eye movements (HP:0000514)1.93353364
127Splenomegaly (HP:0001744)1.90251705
128Abnormal platelet volume (HP:0011876)1.89528933
129Abnormality of purine metabolism (HP:0004352)1.85974767
130Joint hemorrhage (HP:0005261)1.85534823
131Thoracic kyphosis (HP:0002942)1.81604856
132Epistaxis (HP:0000421)1.80737924
133Abnormality of the prostate (HP:0008775)1.80584401
134Thick nail (HP:0001805)1.80330374
135Nonimmune hydrops fetalis (HP:0001790)1.79982016
136Increased mean platelet volume (HP:0011877)1.79608859
137Nasal polyposis (HP:0100582)1.79313501
138Hemorrhage of the eye (HP:0011885)1.76834844
139Gingival bleeding (HP:0000225)1.76652294
140Bone pain (HP:0002653)1.76318759
141Chronic otitis media (HP:0000389)1.76212221
142Abnormality of the lumbar spine (HP:0100712)1.75482839
143Bone cyst (HP:0012062)1.75255392
144Mucosal telangiectasiae (HP:0100579)1.74920061
145Granulocytopenia (HP:0001913)1.73905186
146Combined immunodeficiency (HP:0005387)1.73003386

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.55833636
2BLK3.37911654
3TBK12.65133358
4BMPR22.52791555
5MAP4K12.49852736
6MST1R2.41796283
7TYK22.38573746
8TRIB32.38138494
9RIPK42.33356290
10TAOK22.15772446
11PRPF4B2.10982767
12STK102.08248065
13NME22.06708595
14PIM22.02711234
15EIF2AK11.99869330
16KIT1.96648594
17MAP3K141.78823072
18NEK91.71205052
19ZAP701.70687549
20LRRK21.66803730
21MST41.65703451
22IRAK31.65472542
23IKBKE1.65016035
24TESK21.63124109
25IRAK41.62389927
26TAOK11.61768340
27GRK61.58008092
28SCYL21.56261532
29MAP3K11.55739250
30PKN21.52085654
31CAMK1D1.50278864
32PBK1.48552114
33TGFBR21.43452292
34IKBKB1.42066848
35JAK31.37541812
36FRK1.36400054
37CSF1R1.36304069
38JAK11.36135767
39CLK11.30144506
40RIPK11.28079657
41TRPM71.26471052
42BMX1.23738681
43RPS6KA41.22969085
44MAP2K31.22925678
45SYK1.22684403
46PIM11.22370657
47MAP3K101.22119471
48KDR1.20208551
49CSK1.19983287
50TTN1.15432089
51TNK21.15410310
52STK41.13673987
53MAP3K21.11146427
54HCK1.05556780
55RAF11.05499881
56ABL21.04685816
57EPHB11.04604545
58CDK60.99874905
59TESK10.99775477
60PTK60.96951349
61IRAK10.96412323
62LYN0.96199366
63PAK40.96103328
64TAOK30.94549613
65MAP3K80.94212231
66EEF2K0.92424035
67BTK0.92021993
68JAK20.89698945
69FES0.88798511
70PIK3CG0.88174736
71FLT30.88170121
72GRK70.87787847
73TXK0.87482989
74MAP3K110.86832408
75MAP3K30.85078510
76LCK0.84852668
77DAPK20.78310960
78STK30.76184425
79MATK0.75956621
80MET0.71161581
81IRAK20.70503938
82FGFR40.69985269
83FGR0.69219473
84PDK10.68547275
85KSR10.67022243
86PRKG20.66217481
87MOS0.65342181
88TEC0.64990158
89CAMKK20.64759413
90YES10.64257665
91MAP3K130.63091334
92MAP3K60.59661968
93PDPK10.59616500
94FGFR30.59090422
95HIPK20.56687348
96EGFR0.56477385
97GRK50.56382802
98MAPK120.55479980
99MAPK110.55427921
100PRKCD0.54823221
101MARK20.52913686
102SIK30.52564913
103ABL10.52040251
104NEK20.50395596
105RET0.49429190
106CHUK0.49252085
107PTK2B0.48074520
108CDK40.47912750
109MAP2K10.47862698
110MAPKAPK20.46188710
111CDK120.45123800
112MAPKAPK30.44875534
113MARK30.43763879
114ACVR1B0.42115445
115CAMK1G0.42094723
116ITK0.41943146
117PAK20.40581327
118SIK10.39110956
119CCNB10.38572721
120DYRK30.38233995
121MAP3K50.36762937
122CDC42BPA0.36143379
123PTK20.35667899
124DAPK30.35601212
125FYN0.35373249
126PLK20.34782644
127TGFBR10.33893150
128KSR20.33739351
129BRAF0.31283107
130PRKCQ0.30785355
131ALK0.30765055
132SGK30.30718916
133PAK10.30466469
134DYRK1B0.29107812
135MAP2K60.28699268
136WNK10.26616528
137PRKACG0.24602125
138MAPK30.22014438
139RPS6KC10.21391847

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.20235607
2Caffeine metabolism_Homo sapiens_hsa002322.82765996
3Leishmaniasis_Homo sapiens_hsa051402.69676052
4Lysosome_Homo sapiens_hsa041422.52022748
5Other glycan degradation_Homo sapiens_hsa005112.25651420
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04584961
7Glycosaminoglycan degradation_Homo sapiens_hsa005311.97895905
8Renin-angiotensin system_Homo sapiens_hsa046141.95969329
9Malaria_Homo sapiens_hsa051441.95219738
10Legionellosis_Homo sapiens_hsa051341.93150406
11Pertussis_Homo sapiens_hsa051331.90666260
12Tuberculosis_Homo sapiens_hsa051521.90235601
13Osteoclast differentiation_Homo sapiens_hsa043801.86896140
14Autoimmune thyroid disease_Homo sapiens_hsa053201.83820967
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.81599852
16Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.75611839
17Phagosome_Homo sapiens_hsa041451.69062337
18Mineral absorption_Homo sapiens_hsa049781.65762146
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.56771191
20Type I diabetes mellitus_Homo sapiens_hsa049401.49255934
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48839766
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48665351
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48380610
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45564088
25Measles_Homo sapiens_hsa051621.44071584
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42936773
27Rheumatoid arthritis_Homo sapiens_hsa053231.42496007
28Apoptosis_Homo sapiens_hsa042101.36840905
29Hematopoietic cell lineage_Homo sapiens_hsa046401.34559973
30Shigellosis_Homo sapiens_hsa051311.33800722
31Salmonella infection_Homo sapiens_hsa051321.31843727
32Complement and coagulation cascades_Homo sapiens_hsa046101.31778185
33Fat digestion and absorption_Homo sapiens_hsa049751.29550841
34Influenza A_Homo sapiens_hsa051641.27600713
35Vitamin digestion and absorption_Homo sapiens_hsa049771.26489135
36Pentose phosphate pathway_Homo sapiens_hsa000301.25975671
37B cell receptor signaling pathway_Homo sapiens_hsa046621.25581924
38PPAR signaling pathway_Homo sapiens_hsa033201.25534513
39Antigen processing and presentation_Homo sapiens_hsa046121.20324320
40Toxoplasmosis_Homo sapiens_hsa051451.20202816
41Non-small cell lung cancer_Homo sapiens_hsa052231.17385191
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.16480882
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14065024
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.13698008
45T cell receptor signaling pathway_Homo sapiens_hsa046601.12573264
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12141783
47TNF signaling pathway_Homo sapiens_hsa046681.11749022
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.09471157
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05547421
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04334021
51Glutathione metabolism_Homo sapiens_hsa004801.01966789
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99544012
53Hepatitis C_Homo sapiens_hsa051600.97179735
54Galactose metabolism_Homo sapiens_hsa000520.96551029
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96004486
56Herpes simplex infection_Homo sapiens_hsa051680.94807117
57Hepatitis B_Homo sapiens_hsa051610.93505708
58VEGF signaling pathway_Homo sapiens_hsa043700.91531183
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88085967
60Collecting duct acid secretion_Homo sapiens_hsa049660.84245150
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83688862
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82050834
63Chronic myeloid leukemia_Homo sapiens_hsa052200.81496891
64Starch and sucrose metabolism_Homo sapiens_hsa005000.81266936
65Graft-versus-host disease_Homo sapiens_hsa053320.80068251
66Glycerolipid metabolism_Homo sapiens_hsa005610.79525103
67Amoebiasis_Homo sapiens_hsa051460.78546922
68Asthma_Homo sapiens_hsa053100.76291059
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75109511
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.73840217
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73820103
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73297791
73Folate biosynthesis_Homo sapiens_hsa007900.73061725
74Pancreatic cancer_Homo sapiens_hsa052120.71421794
75Prolactin signaling pathway_Homo sapiens_hsa049170.70558951
76Small cell lung cancer_Homo sapiens_hsa052220.69212968
77Primary immunodeficiency_Homo sapiens_hsa053400.69083132
78Chemokine signaling pathway_Homo sapiens_hsa040620.68231763
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.68219508
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65063145
81Type II diabetes mellitus_Homo sapiens_hsa049300.64984619
82Allograft rejection_Homo sapiens_hsa053300.64815873
83Histidine metabolism_Homo sapiens_hsa003400.64608032
84Renal cell carcinoma_Homo sapiens_hsa052110.64126828
85Platelet activation_Homo sapiens_hsa046110.63446780
86Systemic lupus erythematosus_Homo sapiens_hsa053220.63073405
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.61902529
88Fatty acid degradation_Homo sapiens_hsa000710.61831993
89African trypanosomiasis_Homo sapiens_hsa051430.61382980
90Acute myeloid leukemia_Homo sapiens_hsa052210.61093111
91p53 signaling pathway_Homo sapiens_hsa041150.60706586
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60517964
93Fructose and mannose metabolism_Homo sapiens_hsa000510.60419994
94Viral carcinogenesis_Homo sapiens_hsa052030.58672103
95Endocytosis_Homo sapiens_hsa041440.58214206
96Sphingolipid metabolism_Homo sapiens_hsa006000.57418705
97Viral myocarditis_Homo sapiens_hsa054160.57272782
98Peroxisome_Homo sapiens_hsa041460.57173455
99Epstein-Barr virus infection_Homo sapiens_hsa051690.56946303
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55982628
101Carbon metabolism_Homo sapiens_hsa012000.53471452
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.52994253
103mTOR signaling pathway_Homo sapiens_hsa041500.51484791
104Bladder cancer_Homo sapiens_hsa052190.51446225
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51294803
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50316493
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50128862
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50000715
109ABC transporters_Homo sapiens_hsa020100.48183478
110Arginine biosynthesis_Homo sapiens_hsa002200.48040100
111HIF-1 signaling pathway_Homo sapiens_hsa040660.47676267
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44844693
113Proteoglycans in cancer_Homo sapiens_hsa052050.44322256
114Prion diseases_Homo sapiens_hsa050200.43615629
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43315666
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.42399363
117beta-Alanine metabolism_Homo sapiens_hsa004100.41577067
118Proteasome_Homo sapiens_hsa030500.40665039
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35576381
120Arachidonic acid metabolism_Homo sapiens_hsa005900.31358896
121HTLV-I infection_Homo sapiens_hsa051660.31341964
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.30742624
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30499945
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29566085
125FoxO signaling pathway_Homo sapiens_hsa040680.29104743
126Regulation of autophagy_Homo sapiens_hsa041400.27529795
127Endometrial cancer_Homo sapiens_hsa052130.27175826
128Choline metabolism in cancer_Homo sapiens_hsa052310.26211636

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