MPP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. Alternatively spliced transcript variants have been identified. One transcript variant is experimentally supported, but it doesn't encode a protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.10337721
2neuronal action potential propagation (GO:0019227)5.14301970
3behavioral response to nicotine (GO:0035095)5.04600220
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.91896266
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.90914620
6nucleobase catabolic process (GO:0046113)4.81373968
7ionotropic glutamate receptor signaling pathway (GO:0035235)4.74154607
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.72080424
9neuron cell-cell adhesion (GO:0007158)4.52955649
10locomotory exploration behavior (GO:0035641)4.49446524
11establishment of mitochondrion localization (GO:0051654)4.47354212
12synaptic transmission, glutamatergic (GO:0035249)4.46424191
13vocalization behavior (GO:0071625)4.44203066
14glutamate receptor signaling pathway (GO:0007215)4.42243690
15response to pheromone (GO:0019236)4.35578103
16startle response (GO:0001964)4.31505288
17presynaptic membrane organization (GO:0097090)4.16377893
18regulation of glutamate receptor signaling pathway (GO:1900449)4.15792523
19regulation of synaptic vesicle exocytosis (GO:2000300)4.15282998
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.14963271
21presynaptic membrane assembly (GO:0097105)4.13823047
22olfactory bulb development (GO:0021772)4.09418427
23synaptic vesicle exocytosis (GO:0016079)4.06121295
24G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.05434984
25negative regulation of synaptic transmission, GABAergic (GO:0032229)4.03615076
26neuron-neuron synaptic transmission (GO:0007270)4.02957791
27protein localization to synapse (GO:0035418)3.97521207
28auditory behavior (GO:0031223)3.96773658
29postsynaptic membrane organization (GO:0001941)3.90781068
30synaptic vesicle maturation (GO:0016188)3.88286247
31cerebellar granule cell differentiation (GO:0021707)3.84869878
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.83390496
33establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.82887015
34mitochondrion transport along microtubule (GO:0047497)3.82887015
35transmission of nerve impulse (GO:0019226)3.81274123
36cell migration in hindbrain (GO:0021535)3.77530548
37regulation of synaptic vesicle transport (GO:1902803)3.72605782
38gamma-aminobutyric acid signaling pathway (GO:0007214)3.68397073
39glutamate secretion (GO:0014047)3.67949935
40cerebellar Purkinje cell differentiation (GO:0021702)3.66211997
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64904304
42positive regulation of mitochondrial fission (GO:0090141)3.59427218
43neurotransmitter-gated ion channel clustering (GO:0072578)3.57972404
44long-term memory (GO:0007616)3.56002406
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.54710509
46mechanosensory behavior (GO:0007638)3.49866968
47exploration behavior (GO:0035640)3.49149765
48neurotransmitter secretion (GO:0007269)3.44446184
49dendritic spine morphogenesis (GO:0060997)3.43036625
50regulation of neuronal synaptic plasticity (GO:0048168)3.42264280
51regulation of synapse maturation (GO:0090128)3.42180951
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.42097661
53positive regulation of membrane potential (GO:0045838)3.39805422
54regulation of neurotransmitter secretion (GO:0046928)3.38344389
55response to auditory stimulus (GO:0010996)3.36821047
56regulation of long-term neuronal synaptic plasticity (GO:0048169)3.36495936
57retinal ganglion cell axon guidance (GO:0031290)3.35970875
58regulation of postsynaptic membrane potential (GO:0060078)3.35089159
59positive regulation of synapse assembly (GO:0051965)3.29703313
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25976085
61innervation (GO:0060384)3.22670178
62axon extension (GO:0048675)3.20810633
63regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.20312867
64synaptic vesicle endocytosis (GO:0048488)3.17891520
65positive regulation of synapse maturation (GO:0090129)3.16811388
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.16773814
67neuron recognition (GO:0008038)3.16638529
68synapse assembly (GO:0007416)3.15350753
69neurofilament cytoskeleton organization (GO:0060052)3.15235389
70gamma-aminobutyric acid transport (GO:0015812)3.14415135
71negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.14093427
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.11726993
73regulation of respiratory system process (GO:0044065)3.11005914
74membrane hyperpolarization (GO:0060081)3.10629856
75adult walking behavior (GO:0007628)3.07739177
76regulation of vesicle fusion (GO:0031338)3.07004056
77cell differentiation in hindbrain (GO:0021533)3.06143742
78regulation of neurotransmitter transport (GO:0051588)3.06133712
79long-term synaptic potentiation (GO:0060291)3.05357201
80neurotransmitter transport (GO:0006836)3.03287127
81positive regulation of neurotransmitter secretion (GO:0001956)3.03283957
82detection of calcium ion (GO:0005513)3.02811410
83axonal fasciculation (GO:0007413)3.02681316
84righting reflex (GO:0060013)2.97584879
85central nervous system neuron axonogenesis (GO:0021955)2.96642869
86central nervous system projection neuron axonogenesis (GO:0021952)2.96140051
87regulation of synaptic transmission, GABAergic (GO:0032228)2.95687382
88regulation of collateral sprouting (GO:0048670)2.95486193
89neuronal ion channel clustering (GO:0045161)2.95309587
90neuromuscular synaptic transmission (GO:0007274)2.93024501
91negative regulation of axon guidance (GO:1902668)2.92029541
92regulation of respiratory gaseous exchange (GO:0043576)2.91692765
93membrane depolarization (GO:0051899)2.89965753
94regulation of synapse structural plasticity (GO:0051823)2.88405813
95hippocampus development (GO:0021766)2.87723678
96cochlea development (GO:0090102)2.86288796
97regulation of synaptic plasticity (GO:0048167)2.84008635
98serotonin receptor signaling pathway (GO:0007210)2.83206497
99positive regulation of dendritic spine morphogenesis (GO:0061003)2.81788892
100neuromuscular process controlling posture (GO:0050884)2.80749760
101neuron projection extension (GO:1990138)2.79986561
102regulation of synapse assembly (GO:0051963)2.78949504
103learning (GO:0007612)2.78060007
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.77139148
105dendrite development (GO:0016358)2.76470684
106protein localization to cilium (GO:0061512)2.75038961
107positive regulation of neurotransmitter transport (GO:0051590)2.74054645
108synaptic transmission (GO:0007268)2.73520535
109dendrite morphogenesis (GO:0048813)2.73026775
110negative regulation of dendrite development (GO:2000171)2.72545735
111adult behavior (GO:0030534)2.72441250
112L-amino acid import (GO:0043092)2.69542264
113negative regulation of axon extension (GO:0030517)2.68523345
114membrane depolarization during action potential (GO:0086010)2.68462948
115dendritic spine organization (GO:0097061)2.68221056
116nonmotile primary cilium assembly (GO:0035058)2.68092401
117cerebral cortex radially oriented cell migration (GO:0021799)2.67868791
118layer formation in cerebral cortex (GO:0021819)2.67495888
119adult locomotory behavior (GO:0008344)2.66909224
120regulation of neurotransmitter levels (GO:0001505)2.66407964
121regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.66092887
122regulation of synapse organization (GO:0050807)2.65989306
123regulation of microtubule-based movement (GO:0060632)2.65754633
124spinal cord development (GO:0021510)2.65745005
125negative regulation of microtubule polymerization (GO:0031115)2.62472780
126regulation of cilium movement (GO:0003352)2.61436124
127synaptic transmission, cholinergic (GO:0007271)2.60750931
128intraciliary transport (GO:0042073)2.56684602
129negative regulation of axonogenesis (GO:0050771)2.54369313
130calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.52840207
131axon extension involved in axon guidance (GO:0048846)2.51780694
132neuron projection extension involved in neuron projection guidance (GO:1902284)2.51780694
133cranial nerve morphogenesis (GO:0021602)2.50578294
134regulation of axon guidance (GO:1902667)2.49263254
135substrate-independent telencephalic tangential migration (GO:0021826)2.49091119
136substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.49091119
137regulation of extent of cell growth (GO:0061387)2.49002627
138cytoskeleton-dependent intracellular transport (GO:0030705)2.46090308
139negative regulation of axon extension involved in axon guidance (GO:0048843)2.45481214
140positive regulation of action potential (GO:0045760)2.44242717
141sympathetic nervous system development (GO:0048485)2.43855361
142protein polyglutamylation (GO:0018095)2.43536149
143regulation of mitochondrial fission (GO:0090140)2.43088825
144regulation of membrane repolarization (GO:0060306)2.42784904
145regulation of action potential (GO:0098900)2.40832929
146ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.40294945
147ephrin receptor signaling pathway (GO:0048013)2.39910638
148striatum development (GO:0021756)2.39307841
149regulation of axon extension (GO:0030516)2.38925950
150ganglion development (GO:0061548)2.38797887
151synapse organization (GO:0050808)2.35993024
152cerebral cortex neuron differentiation (GO:0021895)2.35977558
153organelle transport along microtubule (GO:0072384)2.35104749
154axonogenesis (GO:0007409)2.33913642
155regulation of dendritic spine morphogenesis (GO:0061001)2.33349305
156neuron migration (GO:0001764)2.32112986

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.97433456
2GBX2_23144817_ChIP-Seq_PC3_Human4.08038081
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03565407
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99273041
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93732479
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.74744409
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.66574717
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61766026
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57785822
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57785822
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.56346495
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54395899
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54249373
14REST_21632747_ChIP-Seq_MESCs_Mouse2.43384278
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42096423
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38859628
17* EZH2_27294783_Chip-Seq_ESCs_Mouse2.28321455
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.24955050
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24701394
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22664336
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22524965
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22497787
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21514156
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.20563338
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15443540
26DROSHA_22980978_ChIP-Seq_HELA_Human2.13198532
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08141685
28BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03590831
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.96277545
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85444144
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79677517
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.78316962
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76942691
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76590700
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76261905
36TAF15_26573619_Chip-Seq_HEK293_Human1.73079791
37P300_19829295_ChIP-Seq_ESCs_Human1.68842477
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65822290
39RNF2_27304074_Chip-Seq_NSC_Mouse1.65345156
40SMAD4_21799915_ChIP-Seq_A2780_Human1.65196374
41IGF1R_20145208_ChIP-Seq_DFB_Human1.63434736
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.62988225
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61182755
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58973197
45* RARB_27405468_Chip-Seq_BRAIN_Mouse1.58586593
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57996744
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57733596
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48911618
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.45202047
50AR_21572438_ChIP-Seq_LNCaP_Human1.44872048
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.38081136
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31886714
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.31793950
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30618015
55STAT3_23295773_ChIP-Seq_U87_Human1.30111594
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.28355344
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28152212
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27660385
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27004924
60ZNF274_21170338_ChIP-Seq_K562_Hela1.25888970
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25288934
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.24084443
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.23613521
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21265219
65TCF4_23295773_ChIP-Seq_U87_Human1.20893608
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.20415262
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20154704
68FUS_26573619_Chip-Seq_HEK293_Human1.19006264
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18622880
70EWS_26573619_Chip-Seq_HEK293_Human1.17879345
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17524214
72RUNX2_22187159_ChIP-Seq_PCA_Human1.16278561
73AR_25329375_ChIP-Seq_VCAP_Human1.16264071
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16254741
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15640849
76VDR_22108803_ChIP-Seq_LS180_Human1.14790705
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.14703508
78KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13769119
79ER_23166858_ChIP-Seq_MCF-7_Human1.13318943
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13218599
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13215368
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13088266
83P53_22387025_ChIP-Seq_ESCs_Mouse1.12671834
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12313359
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12313359
86OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11173793
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10769282
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.10638814
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07952972
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06961900
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.06342751
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06297749
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.06235415
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.05641607
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05431963
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05407661
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05215862
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.05064730
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.04842263
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04676133
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04620648
102IRF1_19129219_ChIP-ChIP_H3396_Human1.03927336
103POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03780024
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03378199
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03032851
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02830706
107* RING1B_27294783_Chip-Seq_NPCs_Mouse1.02649190
108AR_19668381_ChIP-Seq_PC3_Human1.02543774
109NMYC_18555785_Chip-Seq_ESCs_Mouse1.02356678
110P300_18555785_Chip-Seq_ESCs_Mouse1.01978372
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01215156
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00730955
113SOX2_18555785_Chip-Seq_ESCs_Mouse0.99651003
114JUN_21703547_ChIP-Seq_K562_Human0.99288375
115SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98672993
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98352377
117RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97945462
118SOX9_26525672_Chip-Seq_HEART_Mouse0.97755393
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96792851
120EZH2_27294783_Chip-Seq_NPCs_Mouse0.96529561
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94331091
122KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91017242
123TP53_22573176_ChIP-Seq_HFKS_Human0.87715762
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86613325
125SOX2_16153702_ChIP-ChIP_HESCs_Human0.85187827
126ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84954847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.68929124
2MP0003880_abnormal_central_pattern4.19747823
3MP0003635_abnormal_synaptic_transmissio3.38200873
4MP0009046_muscle_twitch3.12188226
5MP0009745_abnormal_behavioral_response3.01992583
6MP0005423_abnormal_somatic_nervous2.76521577
7MP0002063_abnormal_learning/memory/cond2.70395066
8MP0002064_seizures2.68758265
9MP0001188_hyperpigmentation2.66808635
10MP0001486_abnormal_startle_reflex2.63872678
11MP0002272_abnormal_nervous_system2.61073891
12MP0004270_analgesia2.58670800
13MP0002572_abnormal_emotion/affect_behav2.57174675
14MP0001968_abnormal_touch/_nociception2.55404925
15MP0002735_abnormal_chemical_nociception2.37954326
16MP0002734_abnormal_mechanical_nocicepti2.27097205
17MP0002736_abnormal_nociception_after2.19069230
18MP0006292_abnormal_olfactory_placode2.14220279
19MP0005645_abnormal_hypothalamus_physiol2.13053822
20MP0002184_abnormal_innervation2.10030650
21MP0002067_abnormal_sensory_capabilities2.09936319
22MP0001984_abnormal_olfaction2.08297612
23MP0002822_catalepsy2.04024835
24MP0005646_abnormal_pituitary_gland2.03625344
25MP0010386_abnormal_urinary_bladder2.01011355
26MP0001440_abnormal_grooming_behavior1.95382013
27MP0008569_lethality_at_weaning1.95068670
28MP0000778_abnormal_nervous_system1.91592014
29MP0001501_abnormal_sleep_pattern1.90231973
30MP0002557_abnormal_social/conspecific_i1.90023652
31MP0003121_genomic_imprinting1.88772230
32MP0003787_abnormal_imprinting1.82737047
33MP0006276_abnormal_autonomic_nervous1.78625615
34MP0004742_abnormal_vestibular_system1.75601988
35MP0005171_absent_coat_pigmentation1.74774915
36MP0001970_abnormal_pain_threshold1.73831903
37MP0001502_abnormal_circadian_rhythm1.69227359
38MP0002733_abnormal_thermal_nociception1.61717830
39MP0004142_abnormal_muscle_tone1.58119963
40MP0000751_myopathy1.57646590
41MP0004924_abnormal_behavior1.54991957
42MP0005386_behavior/neurological_phenoty1.54991957
43MP0003123_paternal_imprinting1.54773748
44MP0003879_abnormal_hair_cell1.51009879
45MP0002638_abnormal_pupillary_reflex1.50400441
46MP0004145_abnormal_muscle_electrophysio1.50003723
47MP0001299_abnormal_eye_distance/1.49862131
48MP0003890_abnormal_embryonic-extraembry1.48812499
49MP0002837_dystrophic_cardiac_calcinosis1.48175960
50MP0001905_abnormal_dopamine_level1.44995286
51MP0002234_abnormal_pharynx_morphology1.42588122
52MP0001529_abnormal_vocalization1.41187738
53MP0000955_abnormal_spinal_cord1.40827488
54MP0002882_abnormal_neuron_morphology1.38222494
55MP0005394_taste/olfaction_phenotype1.36638791
56MP0005499_abnormal_olfactory_system1.36638791
57MP0005409_darkened_coat_color1.33491640
58MP0005551_abnormal_eye_electrophysiolog1.31228264
59MP0002066_abnormal_motor_capabilities/c1.28500113
60MP0004215_abnormal_myocardial_fiber1.26779315
61MP0004811_abnormal_neuron_physiology1.23030826
62MP0000538_abnormal_urinary_bladder1.22589825
63MP0000631_abnormal_neuroendocrine_gland1.20821457
64MP0001963_abnormal_hearing_physiology1.20244317
65MP0002653_abnormal_ependyma_morphology1.20148935
66MP0006072_abnormal_retinal_apoptosis1.19239832
67MP0002102_abnormal_ear_morphology1.18750869
68MP0003137_abnormal_impulse_conducting1.17085067
69MP0001485_abnormal_pinna_reflex1.16695673
70MP0009780_abnormal_chondrocyte_physiolo1.14684744
71MP0004085_abnormal_heartbeat1.09772339
72MP0003136_yellow_coat_color1.09765555
73MP0003937_abnormal_limbs/digits/tail_de1.09330109
74MP0003283_abnormal_digestive_organ1.09034909
75MP0000026_abnormal_inner_ear1.07564391
76MP0004885_abnormal_endolymph1.06600675
77MP0005360_urolithiasis1.06010200
78MP0000566_synostosis1.05915725
79MP0008789_abnormal_olfactory_epithelium1.05496064
80MP0001986_abnormal_taste_sensitivity1.04500232
81MP0002752_abnormal_somatic_nervous1.03797976
82MP0002152_abnormal_brain_morphology1.02481305
83MP0003122_maternal_imprinting1.02156931
84MP0000049_abnormal_middle_ear0.98527307
85MP0000678_abnormal_parathyroid_gland0.97936535
86MP0005187_abnormal_penis_morphology0.97797237
87MP0003221_abnormal_cardiomyocyte_apopto0.95524128
88MP0008775_abnormal_heart_ventricle0.94180945
89MP0002229_neurodegeneration0.92590161
90MP0001348_abnormal_lacrimal_gland0.92199495
91MP0000015_abnormal_ear_pigmentation0.90956448
92MP0005195_abnormal_posterior_eye0.90380291
93MP0003567_abnormal_fetal_cardiomyocyte0.89456373
94MP0001177_atelectasis0.89129646
95MP0004084_abnormal_cardiac_muscle0.88679374
96MP0000427_abnormal_hair_cycle0.86239645
97MP0002909_abnormal_adrenal_gland0.86163592
98MP0005253_abnormal_eye_physiology0.84900318
99MP0002938_white_spotting0.84471080
100MP0002876_abnormal_thyroid_physiology0.84379003
101MP0004133_heterotaxia0.83744661
102MP0002233_abnormal_nose_morphology0.82802846
103MP0003633_abnormal_nervous_system0.82674184
104MP0000013_abnormal_adipose_tissue0.82578250
105MP0003631_nervous_system_phenotype0.81830869
106MP0002069_abnormal_eating/drinking_beha0.80573014
107MP0004043_abnormal_pH_regulation0.80490637
108MP0003119_abnormal_digestive_system0.80456671
109MP0003942_abnormal_urinary_system0.79185905
110MP0005391_vision/eye_phenotype0.78732210
111MP0003632_abnormal_nervous_system0.78414452
112MP0000920_abnormal_myelination0.75586378
113MP0004858_abnormal_nervous_system0.75007234
114MP0002277_abnormal_respiratory_mucosa0.73826936
115MP0003755_abnormal_palate_morphology0.72868945
116MP0002081_perinatal_lethality0.72587017
117MP0008995_early_reproductive_senescence0.72229536
118MP0000534_abnormal_ureter_morphology0.72097997
119MP0005257_abnormal_intraocular_pressure0.71486996
120MP0003385_abnormal_body_wall0.69952370
121MP0002751_abnormal_autonomic_nervous0.68662206
122MP0008872_abnormal_physiological_respon0.65796915
123MP0000569_abnormal_digit_pigmentation0.65295272
124MP0002160_abnormal_reproductive_system0.64361100
125MP0005379_endocrine/exocrine_gland_phen0.63413610
126MP0001664_abnormal_digestion0.63166691
127MP0008877_abnormal_DNA_methylation0.62948777
128MP0003938_abnormal_ear_development0.61565989
129MP0003861_abnormal_nervous_system0.61108378
130MP0003878_abnormal_ear_physiology0.60808412
131MP0005377_hearing/vestibular/ear_phenot0.60808412
132MP0002163_abnormal_gland_morphology0.59315542

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.61919951
2Febrile seizures (HP:0002373)5.08525247
3Progressive cerebellar ataxia (HP:0002073)4.51833850
4Focal seizures (HP:0007359)4.48479836
5Myokymia (HP:0002411)4.44114343
6Epileptic encephalopathy (HP:0200134)4.30329506
7Visual hallucinations (HP:0002367)4.13331560
8Atonic seizures (HP:0010819)3.88874319
9Broad-based gait (HP:0002136)3.80474574
10Gaze-evoked nystagmus (HP:0000640)3.63234439
11Action tremor (HP:0002345)3.35839548
12Absence seizures (HP:0002121)3.11414089
13Dialeptic seizures (HP:0011146)3.00420591
14Lissencephaly (HP:0001339)2.98751342
15Pachygyria (HP:0001302)2.95311738
16Gait imbalance (HP:0002141)2.84980920
17Generalized tonic-clonic seizures (HP:0002069)2.84698319
18Aplasia/Hypoplasia of the brainstem (HP:0007362)2.82604107
19Hypoplasia of the brainstem (HP:0002365)2.82604107
20Type II lissencephaly (HP:0007260)2.82025627
21Medial flaring of the eyebrow (HP:0010747)2.75668278
22Hyperventilation (HP:0002883)2.72533584
23Fetal akinesia sequence (HP:0001989)2.71124884
24Polyphagia (HP:0002591)2.56764958
25Scanning speech (HP:0002168)2.54387305
26Congenital primary aphakia (HP:0007707)2.54279633
27Nephrogenic diabetes insipidus (HP:0009806)2.46617371
28Limb dystonia (HP:0002451)2.42750552
29Truncal ataxia (HP:0002078)2.42528284
30Dysdiadochokinesis (HP:0002075)2.40291944
31Failure to thrive in infancy (HP:0001531)2.39289453
32Hemiparesis (HP:0001269)2.37412101
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.36994347
34Absent/shortened dynein arms (HP:0200106)2.36994347
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.36476195
36Ankle clonus (HP:0011448)2.33798771
37Epileptiform EEG discharges (HP:0011182)2.31693927
38Abnormality of the renal medulla (HP:0100957)2.26404012
39Dysmetria (HP:0001310)2.25212716
40Cortical dysplasia (HP:0002539)2.24516345
41Poor eye contact (HP:0000817)2.24060727
42Anxiety (HP:0000739)2.23409385
43Polymicrogyria (HP:0002126)2.22963803
44Absent speech (HP:0001344)2.20918762
45Decreased central vision (HP:0007663)2.20911333
46EEG with generalized epileptiform discharges (HP:0011198)2.20540600
47Cerebellar dysplasia (HP:0007033)2.18952691
48Bundle branch block (HP:0011710)2.16425696
49Left ventricular hypertrophy (HP:0001712)2.16232294
50Abnormality of the lower motor neuron (HP:0002366)2.15532330
51Urinary urgency (HP:0000012)2.15486322
52Intellectual disability, moderate (HP:0002342)2.14344321
53Protruding tongue (HP:0010808)2.10132030
54Vaginal atresia (HP:0000148)2.10016201
55Genital tract atresia (HP:0001827)2.09421763
56Excessive salivation (HP:0003781)2.08238577
57Drooling (HP:0002307)2.08238577
58Abnormal ciliary motility (HP:0012262)2.07534450
59Oligodactyly (hands) (HP:0001180)2.07125112
60Abnormal hair whorl (HP:0010721)2.05577647
61True hermaphroditism (HP:0010459)2.05334633
62Congenital malformation of the right heart (HP:0011723)2.05284429
63Double outlet right ventricle (HP:0001719)2.05284429
64Hypsarrhythmia (HP:0002521)2.04729330
65Abnormality of calcium-phosphate metabolism (HP:0100530)2.04118354
66Aplasia/Hypoplasia of the lens (HP:0008063)2.03195495
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.02367014
68Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02367014
69Amblyopia (HP:0000646)2.00969688
70Hypothermia (HP:0002045)2.00900057
71Spastic tetraplegia (HP:0002510)2.00784198
72Pancreatic cysts (HP:0001737)1.99753501
73Optic nerve hypoplasia (HP:0000609)1.99753125
74Syncope (HP:0001279)1.98415999
75Duplicated collecting system (HP:0000081)1.98412396
76Nonprogressive disorder (HP:0003680)1.97459132
77Tubulointerstitial nephritis (HP:0001970)1.96440315
78Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.96241623
79Impaired smooth pursuit (HP:0007772)1.94480270
80Genetic anticipation (HP:0003743)1.93947933
81Wrist flexion contracture (HP:0001239)1.93538196
82Agitation (HP:0000713)1.93491545
83Abnormal eating behavior (HP:0100738)1.93449237
84Specific learning disability (HP:0001328)1.92875869
85Blue irides (HP:0000635)1.92547674
86Decreased circulating renin level (HP:0003351)1.91129625
87Poor coordination (HP:0002370)1.90583444
88Abnormality of the renal collecting system (HP:0004742)1.90350274
89Micropenis (HP:0000054)1.89455628
90Severe muscular hypotonia (HP:0006829)1.85647688
91Amyotrophic lateral sclerosis (HP:0007354)1.85630407
92Pancreatic fibrosis (HP:0100732)1.85368636
93Prolonged QT interval (HP:0001657)1.84848152
94Septo-optic dysplasia (HP:0100842)1.83197987
95Narrow forehead (HP:0000341)1.82713752
96Hand muscle atrophy (HP:0009130)1.82206496
97Diplopia (HP:0000651)1.82160434
98Abnormality of binocular vision (HP:0011514)1.82160434
99Stereotypic behavior (HP:0000733)1.79169502
100Congenital sensorineural hearing impairment (HP:0008527)1.78963223
101Chromsome breakage (HP:0040012)1.78743410
102Postaxial hand polydactyly (HP:0001162)1.78189773
103Spastic gait (HP:0002064)1.77597680
104Poor suck (HP:0002033)1.77581786
105Gastroesophageal reflux (HP:0002020)1.75007936
106Status epilepticus (HP:0002133)1.74717888
107Urinary bladder sphincter dysfunction (HP:0002839)1.74630188
108Abnormality of ocular smooth pursuit (HP:0000617)1.74567924
109Abnormal respiratory motile cilium morphology (HP:0005938)1.73482541
110Abnormal respiratory epithelium morphology (HP:0012253)1.73482541
111Muscular hypotonia of the trunk (HP:0008936)1.73282305
112Retinal dysplasia (HP:0007973)1.72679295
113Morphological abnormality of the pyramidal tract (HP:0002062)1.71399098
114Tubulointerstitial abnormality (HP:0001969)1.71193035
115Hypoplasia of the corpus callosum (HP:0002079)1.70393413
116Abnormality of the labia minora (HP:0012880)1.69460357
117Abnormality of salivation (HP:0100755)1.67671136
118Anophthalmia (HP:0000528)1.67456854
119Depression (HP:0000716)1.65910005
120Esotropia (HP:0000565)1.65737799
121Hepatoblastoma (HP:0002884)1.65728820
122Primary atrial arrhythmia (HP:0001692)1.65241318
123Anterior segment dysgenesis (HP:0007700)1.65186396
124Nephronophthisis (HP:0000090)1.65095153
125Abnormality of midbrain morphology (HP:0002418)1.64779509
126Molar tooth sign on MRI (HP:0002419)1.64779509
127Atrial fibrillation (HP:0005110)1.64334694
128Abnormal respiratory motile cilium physiology (HP:0012261)1.64013018
129Preaxial hand polydactyly (HP:0001177)1.63914366
130Inability to walk (HP:0002540)1.63584088
131Supraventricular tachycardia (HP:0004755)1.63328212
132Megalencephaly (HP:0001355)1.61977822
133Impaired vibration sensation in the lower limbs (HP:0002166)1.61218020
134Sudden death (HP:0001699)1.60387481
135Absent eyebrow (HP:0002223)1.60194490
136Chronic hepatic failure (HP:0100626)1.60071649
137Aganglionic megacolon (HP:0002251)1.60034525
138Abnormality of the corticospinal tract (HP:0002492)1.59885032
139Thickened helices (HP:0000391)1.59812271
140Decreased testicular size (HP:0008734)1.59592543
141Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.58476020
142Volvulus (HP:0002580)1.58165960
143Sclerocornea (HP:0000647)1.58141654
144Generalized hypopigmentation of hair (HP:0011358)1.57037928
145Sleep apnea (HP:0010535)1.56691595
146Exotropia (HP:0000577)1.56570657
147Rib fusion (HP:0000902)1.56510077
148Oligodactyly (HP:0012165)1.55666907
149Aplasia/Hypoplasia of the tibia (HP:0005772)1.55560527
150Ulnar claw (HP:0001178)1.55510512
151Supraventricular arrhythmia (HP:0005115)1.55404979
152Anencephaly (HP:0002323)1.55123487
153Impaired social interactions (HP:0000735)1.54656268
154Abnormal social behavior (HP:0012433)1.54656268
155Mutism (HP:0002300)1.54315049
156Gait ataxia (HP:0002066)1.54269654
157Spinal canal stenosis (HP:0003416)1.53468742
158Hypoplasia of the fovea (HP:0007750)1.52814149
159Aplasia/Hypoplasia of the fovea (HP:0008060)1.52814149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.11522222
2CASK3.58458972
3MARK13.24249412
4MAP2K73.12905854
5TNIK2.98740086
6EPHA42.98019653
7PRPF4B2.73135631
8TRIM282.45329060
9NTRK22.34728585
10WNK32.26400124
11MAP3K42.23610499
12DYRK22.16653376
13MAPK132.16424849
14DYRK31.84886554
15CDK191.81234698
16MAP4K21.76542492
17PAK31.75201972
18PNCK1.73578818
19MAP3K121.70697557
20BMPR21.69731838
21MINK11.65860007
22LIMK11.61191764
23DAPK21.61159236
24SIK31.60838848
25PINK11.54386926
26INSRR1.54122227
27CSNK1G31.53654679
28EPHA31.49795301
29EPHB21.47793287
30CAMKK21.43652989
31SGK4941.33850998
32SGK2231.33850998
33NEK61.32264698
34SGK21.31836050
35OXSR11.28554772
36PLK21.28261317
37AKT31.26817374
38MAP2K41.24665599
39ZAK1.24328813
40CSNK1G11.24279894
41MAP3K61.23967155
42MAP3K91.22150416
43PRKCG1.18922795
44CDK51.17398883
45IRAK21.15914888
46RIPK41.14456254
47UHMK11.12375388
48WNK41.11746715
49SIK21.09036338
50GRK51.07731147
51RIPK11.06782780
52PKN11.05143005
53PAK61.04576034
54ICK1.02760608
55ERBB31.02103413
56STK381.01041943
57ADRBK20.99809260
58MUSK0.99459872
59CAMK2A0.97443580
60CAMK2B0.94177540
61CAMK10.92827877
62CDK30.92357170
63PRKD30.90252579
64BCR0.89923156
65DYRK1A0.89214498
66PDK20.87769718
67CAMKK10.87301742
68PRKCE0.84180634
69MARK20.81722220
70BCKDK0.80740782
71FES0.79878480
72TESK10.79689996
73FRK0.78906139
74YES10.78178125
75PIM20.77522605
76IRAK40.76487168
77WNK10.74428049
78CAMK1G0.72465511
79CAMK2D0.71473474
80PRKAA10.70591278
81IRAK10.70056144
82GRK70.69064719
83DYRK1B0.68987295
84IRAK30.68815582
85SGK10.68205944
86PHKG10.67856432
87PHKG20.67856432
88DAPK10.66949786
89BMPR1B0.66902822
90NTRK10.64941578
91STK160.64083409
92SGK30.63665829
93KSR10.63403912
94MYLK0.62564244
95CDK180.62542618
96DMPK0.61105899
97NME10.59252332
98TNK20.58744569
99MAPK150.58105705
100EIF2AK20.57390740
101CDK150.57287884
102ARAF0.56488593
103RPS6KA40.56374161
104GRK10.55830952
105CDC42BPA0.55263793
106PBK0.55231106
107CAMK2G0.55137672
108CSNK1G20.55046133
109CDK11A0.54033828
110TAOK20.53423736
111RPS6KA20.53173840
112MAPKAPK50.52961541
113STK390.52250762
114TXK0.51717788
115PKN20.50737729
116BRAF0.49349338
117PRKCZ0.48596167
118PRKACA0.48201221
119PTK20.47851845
120PRKG10.46713665
121CAMK40.46292658
122CDK140.46139968
123CSNK1E0.45796971
124STK110.45595230
125MKNK20.44946580
126BRD40.44226004
127MET0.41729365
128SRPK10.41678872
129ERBB20.41133955
130ADRBK10.40329627
131PRKCH0.40146479
132CSNK1A1L0.39299541
133HIPK20.38869767
134CSNK1A10.38752792
135NEK20.38155654
136RPS6KA50.36635507
137MAP3K110.34376222
138MKNK10.34290588

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.31272513
2Synaptic vesicle cycle_Homo sapiens_hsa047213.05045073
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.95055161
4Glutamatergic synapse_Homo sapiens_hsa047242.79721515
5Circadian entrainment_Homo sapiens_hsa047132.76738893
6Morphine addiction_Homo sapiens_hsa050322.66790727
7GABAergic synapse_Homo sapiens_hsa047272.60300958
8Taste transduction_Homo sapiens_hsa047422.54015190
9Olfactory transduction_Homo sapiens_hsa047402.45583362
10Long-term potentiation_Homo sapiens_hsa047202.35609551
11Amphetamine addiction_Homo sapiens_hsa050312.27419502
12Serotonergic synapse_Homo sapiens_hsa047262.19024552
13Insulin secretion_Homo sapiens_hsa049112.14136386
14Dopaminergic synapse_Homo sapiens_hsa047281.92446982
15Salivary secretion_Homo sapiens_hsa049701.91861086
16Long-term depression_Homo sapiens_hsa047301.90890645
17Cholinergic synapse_Homo sapiens_hsa047251.90600266
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.79590958
19Collecting duct acid secretion_Homo sapiens_hsa049661.77085344
20Calcium signaling pathway_Homo sapiens_hsa040201.64624932
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59097717
22Cocaine addiction_Homo sapiens_hsa050301.51390392
23Phototransduction_Homo sapiens_hsa047441.50862471
24Gastric acid secretion_Homo sapiens_hsa049711.48052688
25Steroid biosynthesis_Homo sapiens_hsa001001.47695882
26Renin secretion_Homo sapiens_hsa049241.44135538
27Oxytocin signaling pathway_Homo sapiens_hsa049211.43168183
28Axon guidance_Homo sapiens_hsa043601.36123688
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35480333
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32467097
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21460056
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20937835
33cAMP signaling pathway_Homo sapiens_hsa040241.19907217
34Type II diabetes mellitus_Homo sapiens_hsa049301.19706090
35Oxidative phosphorylation_Homo sapiens_hsa001901.18159338
36Basal transcription factors_Homo sapiens_hsa030221.16019518
37Vibrio cholerae infection_Homo sapiens_hsa051101.15911337
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15738143
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14627210
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12615661
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12542380
42GnRH signaling pathway_Homo sapiens_hsa049121.10497619
43Gap junction_Homo sapiens_hsa045401.09262372
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08994371
45Cardiac muscle contraction_Homo sapiens_hsa042601.08708379
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07074018
47Alzheimers disease_Homo sapiens_hsa050101.03907527
48Propanoate metabolism_Homo sapiens_hsa006401.02011567
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01448148
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96298558
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90360118
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89877723
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89000434
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88761232
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86768847
56Fatty acid elongation_Homo sapiens_hsa000620.86720171
57Pancreatic secretion_Homo sapiens_hsa049720.85199595
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84281134
59Hippo signaling pathway_Homo sapiens_hsa043900.83318030
60Melanogenesis_Homo sapiens_hsa049160.82529675
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.82079359
62Butanoate metabolism_Homo sapiens_hsa006500.80885000
63Circadian rhythm_Homo sapiens_hsa047100.80527417
64Type I diabetes mellitus_Homo sapiens_hsa049400.80219064
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.79198331
66ErbB signaling pathway_Homo sapiens_hsa040120.76622626
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75781059
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75712140
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75241599
70Tryptophan metabolism_Homo sapiens_hsa003800.75115038
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74348371
72Parkinsons disease_Homo sapiens_hsa050120.73115025
73Rheumatoid arthritis_Homo sapiens_hsa053230.71396945
74Estrogen signaling pathway_Homo sapiens_hsa049150.70505147
75Huntingtons disease_Homo sapiens_hsa050160.68379459
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67852361
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67746424
78Phenylalanine metabolism_Homo sapiens_hsa003600.67631706
79Fatty acid metabolism_Homo sapiens_hsa012120.67294047
80Hedgehog signaling pathway_Homo sapiens_hsa043400.65813038
81Alcoholism_Homo sapiens_hsa050340.65606527
82MAPK signaling pathway_Homo sapiens_hsa040100.64774211
83Choline metabolism in cancer_Homo sapiens_hsa052310.64731600
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64239620
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63978788
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.62499025
87Ras signaling pathway_Homo sapiens_hsa040140.61217903
88Pyruvate metabolism_Homo sapiens_hsa006200.61024842
89RNA polymerase_Homo sapiens_hsa030200.60979363
90Biosynthesis of amino acids_Homo sapiens_hsa012300.60509036
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59673348
92Arginine and proline metabolism_Homo sapiens_hsa003300.58689111
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58435460
94RNA degradation_Homo sapiens_hsa030180.58405997
95Wnt signaling pathway_Homo sapiens_hsa043100.57741567
96Fanconi anemia pathway_Homo sapiens_hsa034600.57697694
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56010278
98Sulfur relay system_Homo sapiens_hsa041220.55558488
99Ovarian steroidogenesis_Homo sapiens_hsa049130.55188968
100Tight junction_Homo sapiens_hsa045300.53839738
101Fatty acid biosynthesis_Homo sapiens_hsa000610.52428388
102Sphingolipid metabolism_Homo sapiens_hsa006000.52287002
103Thyroid hormone synthesis_Homo sapiens_hsa049180.52189246
104Glioma_Homo sapiens_hsa052140.51529879
105Inositol phosphate metabolism_Homo sapiens_hsa005620.51418445
106AMPK signaling pathway_Homo sapiens_hsa041520.51303493
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50357771
108Oocyte meiosis_Homo sapiens_hsa041140.50293059
109African trypanosomiasis_Homo sapiens_hsa051430.49515322
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49490488
111Carbon metabolism_Homo sapiens_hsa012000.49263003
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49097952
113Lysine degradation_Homo sapiens_hsa003100.49059419
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48733365
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48113906
116Dilated cardiomyopathy_Homo sapiens_hsa054140.47920876
117Ether lipid metabolism_Homo sapiens_hsa005650.47023256
118Mineral absorption_Homo sapiens_hsa049780.46097551
119Glucagon signaling pathway_Homo sapiens_hsa049220.44627860
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42592450
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41267640
122mRNA surveillance pathway_Homo sapiens_hsa030150.41231194
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40436285
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39315885
125Peroxisome_Homo sapiens_hsa041460.38835564
126Dorso-ventral axis formation_Homo sapiens_hsa043200.38238640
127Folate biosynthesis_Homo sapiens_hsa007900.38080415
128Basal cell carcinoma_Homo sapiens_hsa052170.37901565
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37608304
130Chemokine signaling pathway_Homo sapiens_hsa040620.37209296
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.35733144
132Protein export_Homo sapiens_hsa030600.35241587
133Rap1 signaling pathway_Homo sapiens_hsa040150.33826148
134Autoimmune thyroid disease_Homo sapiens_hsa053200.33687195
135Regulation of autophagy_Homo sapiens_hsa041400.31996051
136Phagosome_Homo sapiens_hsa041450.23526792
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.23110341
138Melanoma_Homo sapiens_hsa052180.22955084
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22618542
140Endometrial cancer_Homo sapiens_hsa052130.20693937
141Graft-versus-host disease_Homo sapiens_hsa053320.18433864
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18282733

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