MPP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) protein family, with an N-terminal PDZ domain, a central src homology 3 region (SH3), and a C-terminal guanylate kinase-like (GUK) domain. The protein is localized to the outer limiting membrane in the retina, and is thought to function in photoreceptor polarity and the organization of specialized intercellular junctions. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phototransduction, visible light (GO:0007603)9.96995139
2detection of visible light (GO:0009584)9.72499362
3detection of light stimulus (GO:0009583)9.69004227
4positive regulation of guanylate cyclase activity (GO:0031284)8.88105573
5visual perception (GO:0007601)8.59550815
6protein-chromophore linkage (GO:0018298)8.56491274
7sensory perception of light stimulus (GO:0050953)8.51119767
8regulation of guanylate cyclase activity (GO:0031282)8.05650878
9cellular response to light stimulus (GO:0071482)7.39098785
10photoreceptor cell differentiation (GO:0046530)6.92304714
11eye photoreceptor cell differentiation (GO:0001754)6.92304714
12detection of external stimulus (GO:0009581)6.80201139
13retina development in camera-type eye (GO:0060041)6.70249116
14detection of abiotic stimulus (GO:0009582)6.68221173
15regulation of cGMP metabolic process (GO:0030823)6.03038849
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.55539479
17nonmotile primary cilium assembly (GO:0035058)5.54051848
18positive regulation of cGMP biosynthetic process (GO:0030828)5.43253603
19DNA deamination (GO:0045006)5.33003186
20regulation of cGMP biosynthetic process (GO:0030826)5.12023066
21cellular response to radiation (GO:0071478)4.76512767
22behavioral response to nicotine (GO:0035095)4.73364053
23positive regulation of cGMP metabolic process (GO:0030825)4.72844919
24adaptation of signaling pathway (GO:0023058)4.62144884
25receptor guanylyl cyclase signaling pathway (GO:0007168)4.41791168
26tryptophan catabolic process (GO:0006569)4.31872471
27indole-containing compound catabolic process (GO:0042436)4.31872471
28indolalkylamine catabolic process (GO:0046218)4.31872471
29cell morphogenesis involved in neuron differentiation (GO:0048667)4.24950521
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.20967551
31regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.19909367
32sensory perception (GO:0007600)4.08439293
33detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.06741939
34positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.06550309
35indolalkylamine metabolic process (GO:0006586)4.06385529
36regulation of voltage-gated calcium channel activity (GO:1901385)4.05249620
37platelet dense granule organization (GO:0060155)4.02727898
38L-fucose catabolic process (GO:0042355)3.96114045
39fucose catabolic process (GO:0019317)3.96114045
40L-fucose metabolic process (GO:0042354)3.96114045
41estrogen biosynthetic process (GO:0006703)3.93879061
42prenylation (GO:0097354)3.92243489
43protein prenylation (GO:0018342)3.92243489
44positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.90849782
45tryptophan metabolic process (GO:0006568)3.79926516
46response to light stimulus (GO:0009416)3.79055864
47regulation of clathrin-mediated endocytosis (GO:2000369)3.78056898
48retina layer formation (GO:0010842)3.75093137
49kynurenine metabolic process (GO:0070189)3.72535115
50neuron development (GO:0048666)3.64071076
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.51921364
52piRNA metabolic process (GO:0034587)3.51510192
53regulation of short-term neuronal synaptic plasticity (GO:0048172)3.45922069
54regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.44359295
55regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.44359295
56negative regulation of mast cell activation (GO:0033004)3.42521549
57response to pheromone (GO:0019236)3.41799602
58behavioral response to ethanol (GO:0048149)3.38783743
59positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.34841457
60short-term memory (GO:0007614)3.32988162
61cellular potassium ion homeostasis (GO:0030007)3.32681382
62response to histamine (GO:0034776)3.32261969
63protein polyglutamylation (GO:0018095)3.31110275
64tachykinin receptor signaling pathway (GO:0007217)3.30827833
65retina homeostasis (GO:0001895)3.26248948
66membrane hyperpolarization (GO:0060081)3.25107541
67negative regulation of receptor-mediated endocytosis (GO:0048261)3.22241833
68regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.12048107
69cytidine deamination (GO:0009972)3.10300744
70cytidine metabolic process (GO:0046087)3.10300744
71cytidine catabolic process (GO:0006216)3.10300744
72positive regulation of defense response to virus by host (GO:0002230)3.09725084
73positive regulation of neurotransmitter transport (GO:0051590)3.09721305
74negative regulation of telomere maintenance (GO:0032205)3.07491341
75neuronal action potential (GO:0019228)3.06029100
76protein complex biogenesis (GO:0070271)3.05399225
77negative regulation of cytosolic calcium ion concentration (GO:0051481)3.02263739
78mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99007374
79mitochondrial respiratory chain complex I assembly (GO:0032981)2.99007374
80NADH dehydrogenase complex assembly (GO:0010257)2.99007374
81mannosylation (GO:0097502)2.97912358
82amine catabolic process (GO:0009310)2.97464684
83cellular biogenic amine catabolic process (GO:0042402)2.97464684
84sulfation (GO:0051923)2.96289397
85neural tube formation (GO:0001841)2.95901450
86positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.95230678
87synaptic vesicle maturation (GO:0016188)2.95079563
88regulation of penile erection (GO:0060405)2.94961090
89positive regulation of sodium ion transmembrane transport (GO:1902307)2.91899885
90indole-containing compound metabolic process (GO:0042430)2.90634421
91gamma-aminobutyric acid transport (GO:0015812)2.89875872
92chemosensory behavior (GO:0007635)2.88482992
93regulation of meiosis I (GO:0060631)2.87868618
94epithelial cilium movement (GO:0003351)2.87791183
95icosanoid secretion (GO:0032309)2.87740924
96arachidonic acid secretion (GO:0050482)2.87740924
97respiratory chain complex IV assembly (GO:0008535)2.86867118
98DNA methylation involved in gamete generation (GO:0043046)2.84354315
99preassembly of GPI anchor in ER membrane (GO:0016254)2.83496934
100detection of mechanical stimulus involved in sensory perception (GO:0050974)2.83467634
101cilium morphogenesis (GO:0060271)2.83113595
102cilium or flagellum-dependent cell motility (GO:0001539)2.81029233
103nephron tubule morphogenesis (GO:0072078)2.80630851
104nephron epithelium morphogenesis (GO:0072088)2.80630851
105multicellular organism reproduction (GO:0032504)2.80032803
106retinoid metabolic process (GO:0001523)2.76491147
107dopamine transport (GO:0015872)2.75619449
108mitochondrial respiratory chain complex assembly (GO:0033108)2.74865473
109L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.74482888
110CDP-diacylglycerol biosynthetic process (GO:0016024)2.73788668
111pyrimidine ribonucleoside catabolic process (GO:0046133)2.73190692
112peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.71991608
113behavioral response to cocaine (GO:0048148)2.71959392
114potassium ion homeostasis (GO:0055075)2.69672548
115cellular ketone body metabolic process (GO:0046950)2.68028737
116cytochrome complex assembly (GO:0017004)2.66077498
117establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.63793874
118mitochondrion transport along microtubule (GO:0047497)2.63793874
119lipid translocation (GO:0034204)2.63268612
120phospholipid translocation (GO:0045332)2.63268612
121synaptic transmission, dopaminergic (GO:0001963)2.62471616
122G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62016083
123striatum development (GO:0021756)2.61343895
124response to radiation (GO:0009314)2.61128683
125centriole replication (GO:0007099)2.60772439
126aromatic amino acid family catabolic process (GO:0009074)2.60749808
127righting reflex (GO:0060013)2.60712287
128reflex (GO:0060004)2.60376660
129regulation of dopamine metabolic process (GO:0042053)2.59744778
130regulation of catecholamine metabolic process (GO:0042069)2.59744778
131negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.59505146
132regulation of memory T cell differentiation (GO:0043380)2.56787922
133negative regulation of transcription regulatory region DNA binding (GO:2000678)2.56238995
134axoneme assembly (GO:0035082)2.56062252
135CDP-diacylglycerol metabolic process (GO:0046341)2.54906034
136signal peptide processing (GO:0006465)2.54618280
137diterpenoid metabolic process (GO:0016101)2.54314169
138regulation of hippo signaling (GO:0035330)2.53732273
139synaptic vesicle docking involved in exocytosis (GO:0016081)2.52920272
140water-soluble vitamin biosynthetic process (GO:0042364)2.52907898
141protein localization to cilium (GO:0061512)2.52198720
142cilium organization (GO:0044782)2.51746462
143cilium movement (GO:0003341)2.50678935
144ketone body metabolic process (GO:1902224)2.50126117
145auditory receptor cell stereocilium organization (GO:0060088)2.49728896
146somite development (GO:0061053)2.49679838
147regulation of synaptic vesicle exocytosis (GO:2000300)2.49258341
148negative regulation of cation channel activity (GO:2001258)2.48652867
149retinol metabolic process (GO:0042572)2.48359723
150regulation of cilium movement (GO:0003352)2.48277260
151benzene-containing compound metabolic process (GO:0042537)2.47867531
152positive regulation of membrane potential (GO:0045838)2.47503792
153arginine catabolic process (GO:0006527)2.46769263
154synaptic transmission, cholinergic (GO:0007271)2.46402957
155negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.44921754
156negative regulation of calcium ion transmembrane transport (GO:1903170)2.44921754
157amino acid salvage (GO:0043102)2.44578478
158L-methionine salvage (GO:0071267)2.44578478
159L-methionine biosynthetic process (GO:0071265)2.44578478
160DNA double-strand break processing (GO:0000729)2.44287125
161establishment of mitochondrion localization (GO:0051654)2.43197099
162cilium assembly (GO:0042384)2.42987338
163double-strand break repair via homologous recombination (GO:0000724)2.42808469
164detection of chemical stimulus involved in sensory perception (GO:0050907)2.42502087
165recombinational repair (GO:0000725)2.42004348
166primary amino compound metabolic process (GO:1901160)2.41932155
167post-embryonic morphogenesis (GO:0009886)2.41852327
168regulation of neurotransmitter uptake (GO:0051580)2.41147773
169detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.41090055
170replication fork processing (GO:0031297)2.38782280
171inner ear receptor stereocilium organization (GO:0060122)2.35830159
172regulation of action potential (GO:0098900)2.35470784
173phasic smooth muscle contraction (GO:0014821)2.34955426
174opioid receptor signaling pathway (GO:0038003)2.34642575
175positive regulation of fatty acid transport (GO:2000193)2.33722380
176regulation of rhodopsin mediated signaling pathway (GO:0022400)17.5371327
177rhodopsin mediated signaling pathway (GO:0016056)17.2435527
178retinal cone cell development (GO:0046549)13.3996566
179photoreceptor cell development (GO:0042461)12.1460225
180photoreceptor cell maintenance (GO:0045494)11.9478254
181eye photoreceptor cell development (GO:0042462)11.6541567
182detection of light stimulus involved in visual perception (GO:0050908)11.5996759
183detection of light stimulus involved in sensory perception (GO:0050962)11.5996759
184GMP metabolic process (GO:0046037)11.0110905
185retinal rod cell development (GO:0046548)10.2543724
186phototransduction (GO:0007602)10.0045742

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.55766719
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.04490160
3GBX2_23144817_ChIP-Seq_PC3_Human3.47780585
4ZNF274_21170338_ChIP-Seq_K562_Hela3.46791539
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.05091037
6VDR_22108803_ChIP-Seq_LS180_Human2.94942428
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.79524092
8EZH2_22144423_ChIP-Seq_EOC_Human2.76354259
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.69888814
10DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.29453615
11REST_21632747_ChIP-Seq_MESCs_Mouse2.14648656
12* FLI1_27457419_Chip-Seq_LIVER_Mouse2.13259793
13IGF1R_20145208_ChIP-Seq_DFB_Human2.12648900
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.10932627
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08287630
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03417190
17TAF15_26573619_Chip-Seq_HEK293_Human2.02832207
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01155481
19DROSHA_22980978_ChIP-Seq_HELA_Human2.01144878
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.99072675
21FUS_26573619_Chip-Seq_HEK293_Human1.98814928
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97888160
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.96798868
24EWS_26573619_Chip-Seq_HEK293_Human1.95015958
25P53_22127205_ChIP-Seq_FIBROBLAST_Human1.91787424
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88336470
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83124946
28ER_23166858_ChIP-Seq_MCF-7_Human1.82963558
29SMAD3_21741376_ChIP-Seq_HESCs_Human1.80356307
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78920994
31* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77857452
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76564967
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75686389
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70107139
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.68925423
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67510047
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67495484
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.64238250
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63101321
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61735657
41CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60796745
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60398896
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59705609
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59705609
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.58531175
46RING1B_27294783_Chip-Seq_NPCs_Mouse1.57729540
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.57444769
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.54202372
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53940891
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.53897174
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53855430
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50237619
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49902131
54TP53_22573176_ChIP-Seq_HFKS_Human1.49410295
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48932582
56AR_19668381_ChIP-Seq_PC3_Human1.48932354
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48390237
58* NANOG_19829295_ChIP-Seq_ESCs_Human1.47122709
59* SOX2_19829295_ChIP-Seq_ESCs_Human1.47122709
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45724396
61JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45705894
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45371085
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45371085
64AR_25329375_ChIP-Seq_VCAP_Human1.44645330
65AR_21572438_ChIP-Seq_LNCaP_Human1.43269986
66* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42192524
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.41899469
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40344637
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40316104
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36363816
71* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36363015
72ELK4_26923725_Chip-Seq_MESODERM_Mouse1.35993944
73* EZH2_27294783_Chip-Seq_NPCs_Mouse1.35851230
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35004226
75KDM2B_26808549_Chip-Seq_K562_Human1.33458786
76* NFE2_27457419_Chip-Seq_LIVER_Mouse1.32953466
77SMC4_20622854_ChIP-Seq_HELA_Human1.32708683
78* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.32512494
79SMAD4_21799915_ChIP-Seq_A2780_Human1.31534877
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.31403037
81NCOR_22424771_ChIP-Seq_293T_Human1.31361069
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30979650
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30270598
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29107291
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28269285
86TCF4_22108803_ChIP-Seq_LS180_Human1.27545950
87CTCF_20526341_ChIP-Seq_ESCs_Human1.26812707
88RNF2_27304074_Chip-Seq_NSC_Mouse1.25982585
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25704145
90CTCF_27219007_Chip-Seq_Bcells_Human1.25580102
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25491679
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24603633
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24532557
94IRF1_19129219_ChIP-ChIP_H3396_Human1.23956884
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.23897310
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23826231
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21746519
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.21628498
99MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20977914
100SMAD4_21741376_ChIP-Seq_EPCs_Human1.20831171
101STAT3_23295773_ChIP-Seq_U87_Human1.20437361
102FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20239540
103FOXA1_25329375_ChIP-Seq_VCAP_Human1.20239540
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19601085
105* RUNX2_22187159_ChIP-Seq_PCA_Human1.19590887
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18657916
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17543060
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15520942
109GATA3_21878914_ChIP-Seq_MCF-7_Human1.15488526
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14664726
111* CRX_20693478_ChIP-Seq_RETINA_Mouse1.13753956
112ERG_21242973_ChIP-ChIP_JURKAT_Human1.13595804
113* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13038282
114SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12233717
115CDX2_22108803_ChIP-Seq_LS180_Human1.10442643
116* NANOG_18555785_Chip-Seq_ESCs_Mouse1.10136012
117FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10006784
118TP53_16413492_ChIP-PET_HCT116_Human1.09992589
119* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09802586
120AR_20517297_ChIP-Seq_VCAP_Human1.08291671
121WDR5_24793694_ChIP-Seq_LNCAP_Human1.08043985
122CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07782020
123IRF8_22096565_ChIP-ChIP_GC-B_Human1.07743870
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07688888
125SMAD_19615063_ChIP-ChIP_OVARY_Human1.07455229
126* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06355769
127TAF2_19829295_ChIP-Seq_ESCs_Human1.04738915
128CJUN_26792858_Chip-Seq_BT549_Human1.04530411
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04145744
130P68_20966046_ChIP-Seq_HELA_Human1.04048222
131ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03557775
132* P53_22387025_ChIP-Seq_ESCs_Mouse1.01884270
133TBL1_22424771_ChIP-Seq_293T_Human1.01848453
134MYC_18940864_ChIP-ChIP_HL60_Human1.01613127
135HOXB7_26014856_ChIP-Seq_BT474_Human1.01338377
136BCAT_22108803_ChIP-Seq_LS180_Human1.01252296
137NANOG_20526341_ChIP-Seq_ESCs_Human1.01002178
138DPY_21335234_ChIP-Seq_ESCs_Mouse1.00384203
139BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.98835970
140PRDM14_20953172_ChIP-Seq_ESCs_Human0.98760552
141GABP_17652178_ChIP-ChIP_JURKAT_Human0.97824939
142TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97713499
143SA1_27219007_Chip-Seq_Bcells_Human0.97236293
144RING1B_27294783_Chip-Seq_ESCs_Mouse0.97217351
145JUN_21703547_ChIP-Seq_K562_Human0.96437015
146GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96314413
147LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96295431
148TAL1_26923725_Chip-Seq_HPCs_Mouse0.96278067
149EED_16625203_ChIP-ChIP_MESCs_Mouse0.96005619
150FOXH1_21741376_ChIP-Seq_EPCs_Human0.95834436
151* P300_19829295_ChIP-Seq_ESCs_Human0.95529938
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94649256
153TCF4_23295773_ChIP-Seq_U87_Human0.93544319
154IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93421651
155CBP_20019798_ChIP-Seq_JUKART_Human0.93421651
156SMAD4_21741376_ChIP-Seq_HESCs_Human0.93112033
157NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91177324
158TCF4_18268006_ChIP-ChIP_LS174T_Human0.91149017
159NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90687943
160EGR1_19032775_ChIP-ChIP_M12_Human0.89363050
161HTT_18923047_ChIP-ChIP_STHdh_Human0.88011405
162FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87268428
163YY1_22570637_ChIP-Seq_MALME-3M_Human0.86268956
164E2F1_17053090_ChIP-ChIP_MCF-7_Human0.86244744
165GF1_26923725_Chip-Seq_HPCs_Mouse0.85922827
166EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85631384
167CBP_21632823_ChIP-Seq_H3396_Human0.85229440
168OCT1_27270436_Chip-Seq_PROSTATE_Human0.84693411
169YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84052040
170CREB1_26743006_Chip-Seq_LNCaP_Human0.83780296

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.50892089
2MP0005253_abnormal_eye_physiology6.74812858
3MP0006072_abnormal_retinal_apoptosis6.72812178
4MP0000569_abnormal_digit_pigmentation4.00608355
5* MP0005195_abnormal_posterior_eye3.79762857
6MP0003195_calcinosis3.56482134
7MP0001324_abnormal_eye_pigmentation3.42855162
8MP0002638_abnormal_pupillary_reflex3.38748272
9MP0005391_vision/eye_phenotype3.30359223
10MP0002090_abnormal_vision3.01771328
11MP0000372_irregular_coat_pigmentation2.90524515
12MP0002229_neurodegeneration2.66505533
13MP0005423_abnormal_somatic_nervous2.57415524
14MP0008877_abnormal_DNA_methylation2.31855263
15MP0003136_yellow_coat_color2.28315375
16MP0001764_abnormal_homeostasis2.11041589
17MP0002876_abnormal_thyroid_physiology2.04919928
18* MP0002752_abnormal_somatic_nervous2.00167916
19MP0003011_delayed_dark_adaptation10.9176969
20MP0005646_abnormal_pituitary_gland1.98405346
21MP0005174_abnormal_tail_pigmentation1.98011152
22MP0002837_dystrophic_cardiac_calcinosis1.89996292
23MP0005171_absent_coat_pigmentation1.85740123
24MP0001986_abnormal_taste_sensitivity1.83372256
25MP0002736_abnormal_nociception_after1.82638010
26MP0002735_abnormal_chemical_nociception1.81196606
27MP0005645_abnormal_hypothalamus_physiol1.74264639
28MP0002938_white_spotting1.71151789
29MP0006292_abnormal_olfactory_placode1.70918696
30MP0003646_muscle_fatigue1.67003919
31MP0005084_abnormal_gallbladder_morpholo1.64609295
32MP0002234_abnormal_pharynx_morphology1.62670125
33MP0002653_abnormal_ependyma_morphology1.58170215
34MP0003283_abnormal_digestive_organ1.50595118
35MP0001984_abnormal_olfaction1.48362523
36MP0000427_abnormal_hair_cycle1.44901134
37MP0008875_abnormal_xenobiotic_pharmacok1.44343538
38* MP0002882_abnormal_neuron_morphology1.44318851
39MP0001502_abnormal_circadian_rhythm1.37827215
40MP0004147_increased_porphyrin_level1.34716799
41MP0002733_abnormal_thermal_nociception1.34704635
42MP0005075_abnormal_melanosome_morpholog1.33269441
43MP0001485_abnormal_pinna_reflex1.32494281
44MP0003880_abnormal_central_pattern1.32106725
45MP0002138_abnormal_hepatobiliary_system1.29314811
46MP0004133_heterotaxia1.26751627
47MP0004019_abnormal_vitamin_homeostasis1.22635902
48MP0005499_abnormal_olfactory_system1.20402708
49MP0005394_taste/olfaction_phenotype1.20402708
50MP0000015_abnormal_ear_pigmentation1.19494173
51MP0002095_abnormal_skin_pigmentation1.18430961
52MP0002160_abnormal_reproductive_system1.17924172
53MP0002751_abnormal_autonomic_nervous1.17400038
54MP0006054_spinal_hemorrhage1.12521851
55MP0005389_reproductive_system_phenotype1.08095071
56MP0004270_analgesia1.06989128
57MP0001486_abnormal_startle_reflex1.06789458
58MP0005410_abnormal_fertilization1.06397087
59MP0004885_abnormal_endolymph1.05880821
60MP0003718_maternal_effect1.04645744
61MP0003787_abnormal_imprinting1.03570534
62MP0001529_abnormal_vocalization1.03246351
63MP0002272_abnormal_nervous_system1.01057506
64MP0002332_abnormal_exercise_endurance0.97366443
65MP0000230_abnormal_systemic_arterial0.95917022
66MP0005197_abnormal_uvea_morphology0.95179810
67MP0008789_abnormal_olfactory_epithelium0.91823603
68MP0004233_abnormal_muscle_weight0.91708287
69MP0002163_abnormal_gland_morphology0.91530053
70MP0009046_muscle_twitch0.90308809
71MP0000383_abnormal_hair_follicle0.87732063
72MP0005167_abnormal_blood-brain_barrier0.85758584
73MP0005360_urolithiasis0.84478047
74MP0003634_abnormal_glial_cell0.84409602
75MP0008058_abnormal_DNA_repair0.82802405
76MP0002734_abnormal_mechanical_nocicepti0.82579890
77MP0009764_decreased_sensitivity_to0.81463772
78MP0002127_abnormal_cardiovascular_syste0.81366591
79* MP0003950_abnormal_plasma_membrane0.80054379
80MP0002282_abnormal_trachea_morphology0.76490852
81MP0005379_endocrine/exocrine_gland_phen0.75337796
82MP0002064_seizures0.74631570
83MP0000538_abnormal_urinary_bladder0.73457174
84MP0003635_abnormal_synaptic_transmissio0.72783231
85MP0003806_abnormal_nucleotide_metabolis0.71566072
86MP0008775_abnormal_heart_ventricle0.70756694
87MP0001929_abnormal_gametogenesis0.69286916
88MP0001963_abnormal_hearing_physiology0.69189632
89MP0005187_abnormal_penis_morphology0.69031794
90MP0002067_abnormal_sensory_capabilities0.67383744
91MP0009697_abnormal_copulation0.64515609
92MP0010386_abnormal_urinary_bladder0.64324345
93MP0002572_abnormal_emotion/affect_behav0.57973286
94MP0001286_abnormal_eye_development0.56776771
95MP0002063_abnormal_learning/memory/cond0.56688793
96MP0004859_abnormal_synaptic_plasticity0.56627839
97MP0002184_abnormal_innervation0.54645212
98MP0009745_abnormal_behavioral_response0.52007226
99MP0001968_abnormal_touch/_nociception0.51801814
100MP0004145_abnormal_muscle_electrophysio0.49378949
101MP0005376_homeostasis/metabolism_phenot0.49329242
102MP0004742_abnormal_vestibular_system0.48010290
103MP0004142_abnormal_muscle_tone0.47719356
104MP0004043_abnormal_pH_regulation0.47704858
105MP0000026_abnormal_inner_ear0.47435002
106MP0000631_abnormal_neuroendocrine_gland0.46686238
107MP0003890_abnormal_embryonic-extraembry0.46437617
108MP0005386_behavior/neurological_phenoty0.42070030
109MP0004924_abnormal_behavior0.42070030
110MP0004782_abnormal_surfactant_physiolog0.37576666
111MP0004085_abnormal_heartbeat0.36510697
112MP0004215_abnormal_myocardial_fiber0.35990423
113MP0006276_abnormal_autonomic_nervous0.35640346
114MP0005248_abnormal_Harderian_gland0.35193929
115MP0002066_abnormal_motor_capabilities/c0.31894923
116MP0008569_lethality_at_weaning0.31824415
117MP0001905_abnormal_dopamine_level0.30121320
118MP0003137_abnormal_impulse_conducting0.29780693
119MP0003879_abnormal_hair_cell0.28746868
120MP0008004_abnormal_stomach_pH0.28691634
121MP0003868_abnormal_feces_composition0.28361766
122MP0000465_gastrointestinal_hemorrhage0.27970437
123MP0003045_fibrosis0.27325564
124MP0001970_abnormal_pain_threshold0.27295803
125MP0006035_abnormal_mitochondrial_morpho0.27209495
126MP0002152_abnormal_brain_morphology0.26240618
127MP0010030_abnormal_orbit_morphology0.26101078
128MP0000778_abnormal_nervous_system0.25444913
129MP0005620_abnormal_muscle_contractility0.25045268
130MP0002697_abnormal_eye_size0.23633317
131MP0001440_abnormal_grooming_behavior0.23372564
132MP0001188_hyperpigmentation0.21495823
133MP0002102_abnormal_ear_morphology0.21052191
134MP0002557_abnormal_social/conspecific_i0.20925774
135MP0002928_abnormal_bile_duct0.20563141
136MP0005595_abnormal_vascular_smooth0.20389581
137MP0004811_abnormal_neuron_physiology0.20371425
138MP0000955_abnormal_spinal_cord0.20233362
139MP0008961_abnormal_basal_metabolism0.19971731
140MP0003632_abnormal_nervous_system0.19847270
141MP0001501_abnormal_sleep_pattern0.19064616
142MP0005193_abnormal_anterior_eye0.18716684
143MP0003698_abnormal_male_reproductive0.17054549
144MP0005266_abnormal_metabolism0.16807170
145MP0003183_abnormal_peptide_metabolism0.13926826
146MP0001293_anophthalmia0.13920467
147MP0003252_abnormal_bile_duct0.13784753
148MP0002069_abnormal_eating/drinking_beha0.13171400
149MP0008872_abnormal_physiological_respon0.12462173
150MP0003633_abnormal_nervous_system0.12078244

Predicted human phenotypes

RankGene SetZ-score
1Chorioretinal atrophy (HP:0000533)8.88960616
2Pigmentary retinal degeneration (HP:0001146)8.52970926
3Central scotoma (HP:0000603)8.13379929
4Pendular nystagmus (HP:0012043)8.04078260
5Attenuation of retinal blood vessels (HP:0007843)7.86527842
6Dyschromatopsia (HP:0007641)7.49372387
7Abnormality of macular pigmentation (HP:0008002)7.37792411
8Scotoma (HP:0000575)7.33432239
9Abolished electroretinogram (ERG) (HP:0000550)6.68917553
10Decreased central vision (HP:0007663)6.61101291
11Type II diabetes mellitus (HP:0005978)5.57518761
12Photophobia (HP:0000613)5.50828876
13Increased corneal curvature (HP:0100692)5.39270148
14Keratoconus (HP:0000563)5.39270148
15Severe visual impairment (HP:0001141)5.13174481
16Cone-rod dystrophy (HP:0000548)4.86204531
17Macular degeneration (HP:0000608)4.79298073
18Retinitis pigmentosa (HP:0000510)4.59061447
19Vitreoretinal degeneration (HP:0000655)4.50460433
20Constricted visual fields (HP:0001133)4.24020503
21Choroideremia (HP:0001139)4.17732743
22Posterior subcapsular cataract (HP:0007787)3.84287674
23Abnormality of the renal medulla (HP:0100957)3.69813371
24Abnormality of the renal cortex (HP:0011035)3.49238679
25Decreased electroretinogram (ERG) amplitude (HP:0000654)3.43262325
26Progressive visual loss (HP:0000529)2.93514666
27Optic disc pallor (HP:0000543)2.85161808
28Tubular atrophy (HP:0000092)2.75433627
29Renal cortical cysts (HP:0000803)2.73031462
30Congenital sensorineural hearing impairment (HP:0008527)2.72686451
31Gait imbalance (HP:0002141)2.71534351
32Congenital primary aphakia (HP:0007707)2.69366006
33Type II lissencephaly (HP:0007260)2.68834936
34Chronic hepatic failure (HP:0100626)2.62719120
35Retinal atrophy (HP:0001105)2.61421827
36Absent/shortened dynein arms (HP:0200106)2.58656597
37Dynein arm defect of respiratory motile cilia (HP:0012255)2.58656597
38Abnormal biliary tract physiology (HP:0012439)2.54803371
39Bile duct proliferation (HP:0001408)2.54803371
40Wide nasal bridge (HP:0000431)2.48624620
41Congenital, generalized hypertrichosis (HP:0004540)2.47851534
42Aplasia/Hypoplasia of the tibia (HP:0005772)2.44215043
43Inability to walk (HP:0002540)2.40986116
44Nephrogenic diabetes insipidus (HP:0009806)2.37856100
45Medial flaring of the eyebrow (HP:0010747)2.33435027
46Polydipsia (HP:0001959)2.30835113
47Abnormal drinking behavior (HP:0030082)2.30835113
48Progressive inability to walk (HP:0002505)2.25305959
49Clumsiness (HP:0002312)2.24266843
50Hypothermia (HP:0002045)2.22597770
51Absent speech (HP:0001344)2.20340648
52Broad-based gait (HP:0002136)2.19690668
53Subcapsular cataract (HP:0000523)2.18641131
54Tubulointerstitial nephritis (HP:0001970)2.17514446
55Mitochondrial inheritance (HP:0001427)2.08735704
56Stomach cancer (HP:0012126)2.08623718
57Poor coordination (HP:0002370)2.05769531
58Focal motor seizures (HP:0011153)2.05735719
59Increased CSF lactate (HP:0002490)2.05511490
60Abnormal ciliary motility (HP:0012262)2.05165220
61Large for gestational age (HP:0001520)2.03650455
62Male pseudohermaphroditism (HP:0000037)2.01657676
63Abnormal respiratory motile cilium morphology (HP:0005938)2.00836664
64Abnormal respiratory epithelium morphology (HP:0012253)2.00836664
65Congenital stationary night blindness (HP:0007642)14.8365611
66Bony spicule pigmentary retinopathy (HP:0007737)11.8068872
67Abnormal rod and cone electroretinograms (HP:0008323)10.4718100
68Absent rod-and cone-mediated responses on ERG (HP:0007688)10.3037175
69Stomatitis (HP:0010280)1.99352398
703-Methylglutaconic aciduria (HP:0003535)1.98379206
71Thyroiditis (HP:0100646)1.96264803
72Tubulointerstitial abnormality (HP:0001969)1.96025338
73Polyuria (HP:0000103)1.95203638
74Hepatocellular necrosis (HP:0001404)1.94264315
75IgG deficiency (HP:0004315)1.93217419
76Thyroid-stimulating hormone excess (HP:0002925)1.93144513
77Concave nail (HP:0001598)1.90230965
78Small hand (HP:0200055)1.89168533
79Lissencephaly (HP:0001339)1.88630655
80Acute necrotizing encephalopathy (HP:0006965)1.87251615
81Short tibia (HP:0005736)1.86667438
82Intestinal atresia (HP:0011100)1.84146102
83Vaginal atresia (HP:0000148)1.82264176
84Hypoproteinemia (HP:0003075)1.79480094
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77298292
86Abnormality of alanine metabolism (HP:0010916)1.77298292
87Hyperalaninemia (HP:0003348)1.77298292
88Occipital encephalocele (HP:0002085)1.77184075
89Genital tract atresia (HP:0001827)1.76744406
90Abnormality of the renal collecting system (HP:0004742)1.76527872
91Supernumerary spleens (HP:0009799)1.76280620
92Abnormality of the pons (HP:0007361)1.75346430
93Preaxial hand polydactyly (HP:0001177)1.75076383
94Aplasia/Hypoplasia involving the musculature (HP:0001460)1.74461849
95Fair hair (HP:0002286)1.73359929
96Disproportionate short-trunk short stature (HP:0003521)1.72996968
97Optic atrophy (HP:0000648)1.71873812
98Methylmalonic aciduria (HP:0012120)1.71569083
99Horizontal nystagmus (HP:0000666)1.71209995
100Focal seizures (HP:0007359)1.70458936
101Optic nerve hypoplasia (HP:0000609)1.70337148
102Hypoplasia of the fovea (HP:0007750)1.69374854
103Aplasia/Hypoplasia of the fovea (HP:0008060)1.69374854
104Pancreatic fibrosis (HP:0100732)1.64261018
105Abnormality of the fovea (HP:0000493)1.59217075
106True hermaphroditism (HP:0010459)1.53326112
107Epileptic encephalopathy (HP:0200134)1.51996981
108Aplasia/Hypoplasia of the lens (HP:0008063)1.51612640
109Dysdiadochokinesis (HP:0002075)1.42805296
110Astigmatism (HP:0000483)1.40579509
111Pancreatic cysts (HP:0001737)1.39823712
112Febrile seizures (HP:0002373)1.36102060
113Interstitial pulmonary disease (HP:0006530)1.30026907
114Severe Myopia (HP:0011003)1.26250201
115Polar cataract (HP:0010696)1.18198649
116Aplasia/Hypoplasia of the macula (HP:0008059)1.17737083
117Broad foot (HP:0001769)1.17258101
118Cystic liver disease (HP:0006706)1.16579734
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.14884156
120Progressive cerebellar ataxia (HP:0002073)1.10892527
121Decreased testicular size (HP:0008734)1.09517553
122Specific learning disability (HP:0001328)1.08608172
123Aplasia/Hypoplasia affecting the retina (HP:0008061)1.06091875
124Chorioretinal coloboma (HP:0000567)1.03844416
125Asthma (HP:0002099)1.03512024
126Truncal ataxia (HP:0002078)1.03277957
127Left ventricular hypertrophy (HP:0001712)1.01412442
128Molar tooth sign on MRI (HP:0002419)1.01123936
129Abnormality of midbrain morphology (HP:0002418)1.01123936
130Abnormality of dental color (HP:0011073)1.00923838
131Septo-optic dysplasia (HP:0100842)0.99128678
132Visual hallucinations (HP:0002367)0.96263469
133Cerebellar dysplasia (HP:0007033)0.96186413
134Abnormality of the lower motor neuron (HP:0002366)0.95129175
135Retinal detachment (HP:0000541)0.90724449
136Sclerocornea (HP:0000647)0.90054374
137Hypermetropia (HP:0000540)0.86859213
138Recurrent sinusitis (HP:0011108)0.84286414
139Anencephaly (HP:0002323)0.83547840
140Absence seizures (HP:0002121)0.79937284
141Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.79841989
142Postaxial hand polydactyly (HP:0001162)0.79691406
143Partial agenesis of the corpus callosum (HP:0001338)0.79047643
144Prolonged QT interval (HP:0001657)0.78997652
145Generalized myoclonic seizures (HP:0002123)0.78280439
146Congenital hepatic fibrosis (HP:0002612)0.74935174
147Genetic anticipation (HP:0003743)0.74741765
148Short foot (HP:0001773)0.74345949
149Furrowed tongue (HP:0000221)0.72526164
150Gaze-evoked nystagmus (HP:0000640)0.72249626
151Dental crowding (HP:0000678)0.70614478
152Postaxial foot polydactyly (HP:0001830)0.70308114
153Hypodontia (HP:0000668)0.69041867
154Abnormal EKG (HP:0003115)0.67641881
155Dialeptic seizures (HP:0011146)0.67247921
156Multicystic kidney dysplasia (HP:0000003)0.67213237
157Prominent nasal bridge (HP:0000426)0.66797365
158Hyperventilation (HP:0002883)0.64797074
159Nephronophthisis (HP:0000090)0.64043467

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK7.36163311
2FRK5.39162380
3PINK13.02847092
4BMPR1B2.79365371
5IRAK22.77376020
6MAP4K22.56261876
7NUAK12.43247086
8TXK2.36100987
9GRK52.04307960
10GRK110.3619733
11CDK121.99466849
12ZAK1.95292473
13SIK21.94136201
14WNK41.88969608
15WNK31.79903445
16ACVR1B1.73507839
17STK38L1.63653319
18ADRBK11.53762959
19AKT31.51510702
20MAPK71.50616657
21LATS11.48639269
22FLT31.43040563
23BRD41.43027027
24TIE11.41919503
25MARK11.36156920
26STK391.34264429
27HIPK21.27621522
28STK381.27461773
29MAPK121.27345576
30OXSR11.26475760
31MAP3K41.26367256
32PTK2B1.22228210
33NEK11.21908427
34PNCK1.21527840
35DYRK1A1.19988778
36DAPK21.16816281
37SGK2231.16221406
38SGK4941.16221406
39PAK31.15223689
40TAOK31.11716699
41CAMKK21.10892055
42TRIM281.06450802
43TGFBR11.04122903
44FES1.03792304
45PAK61.03240794
46PRKCE1.01617204
47BCKDK1.01552601
48TEC1.00228966
49MAP2K70.98445957
50WNK10.96210034
51MAP3K100.94741770
52MUSK0.94502910
53KIT0.92953978
54PIK3CG0.91547339
55CAMK1G0.87782346
56PRPF4B0.87363062
57SGK20.86315382
58PHKG20.84076847
59PHKG10.84076847
60PRKAA10.83115844
61STK30.82929821
62ERBB20.82915001
63CAMK2D0.82431351
64CSNK1D0.81184624
65INSRR0.80210257
66PIK3CA0.79810456
67PRKCZ0.79423737
68NME10.78908830
69VRK10.78682965
70MAP2K40.78074839
71MAP2K60.77133444
72CDK30.72077021
73PLK20.70245913
74IKBKB0.69684897
75MAPKAPK30.68955804
76PRKD20.66953954
77DYRK1B0.66459374
78TTK0.66252614
79MAPK150.65832633
80EIF2AK30.65609970
81KDR0.65551950
82SGK30.64788702
83PRKCB0.64313186
84ADRBK20.64024708
85TNK20.62100844
86IRAK10.61071237
87PRKAA20.60902221
88BRSK20.60822860
89CAMK10.60445705
90EPHA30.60350501
91CAMK40.60293156
92CAMKK10.59613012
93RPS6KA40.59561671
94PKN10.57541551
95PRKCQ0.56885061
96CASK0.56610358
97DYRK20.56556889
98PRKACG0.53889394
99RPS6KA30.53727527
100PLK40.53016182
101CAMK1D0.51659306
102MST40.50835856
103FER0.50368596
104PRKCG0.49708254
105PDK20.49390852
106TSSK60.48790189
107NEK20.48255383
108MKNK20.47702087
109PRKCI0.47069672
110ICK0.46792093
111GSK3B0.46588082
112MAPK100.46402948
113MINK10.45698836
114MARK20.45141481
115CHEK20.44157453
116CAMK2A0.43714855
117MAP3K70.43250088
118PRKACA0.43005917
119TLK10.42975212
120MAPKAPK50.41080881
121NLK0.40912827
122TNIK0.40202003
123GRK70.39827704
124PRKCH0.39736589
125ERBB30.39707815
126CDK50.38511066
127MAPK90.38399984
128MAPK140.38083234
129RPS6KA50.37268982
130ITK0.36553048
131TAOK20.35990033
132SYK0.35918872
133CDK80.35647594
134CDK10.35520653
135PRKDC0.35223570
136PRKD30.34999804
137CSNK1G20.34443366
138MAP2K10.34189695
139GRK60.34117772
140CSNK1E0.33505278
141IGF1R0.33090895
142CSNK1G10.32925678
143NTRK20.32464955
144EPHA40.32230946
145CHUK0.31335981
146AKT20.30705850
147PLK30.30545272
148SGK10.30295229
149ABL10.30284609
150PRKCA0.30073993
151CHEK10.29815852
152CSNK1A10.28673349
153MAPK130.28087172
154CDK90.26777055
155NTRK30.25770313
156YES10.25649313
157STK110.24879065
158PRKG10.23985473
159NEK60.23661541
160CCNB10.22058474

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.67923631
2Protein export_Homo sapiens_hsa030602.04183188
3Phototransduction_Homo sapiens_hsa0474415.6093675
4Synaptic vesicle cycle_Homo sapiens_hsa047211.94158919
5Homologous recombination_Homo sapiens_hsa034401.93859455
6Butanoate metabolism_Homo sapiens_hsa006501.90556901
7Oxidative phosphorylation_Homo sapiens_hsa001901.83635683
8Basal transcription factors_Homo sapiens_hsa030221.73695409
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72774576
10GABAergic synapse_Homo sapiens_hsa047271.70662023
11RNA polymerase_Homo sapiens_hsa030201.67497528
12Selenocompound metabolism_Homo sapiens_hsa004501.61916950
13Tryptophan metabolism_Homo sapiens_hsa003801.60467095
14Fanconi anemia pathway_Homo sapiens_hsa034601.54079667
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53696285
16Primary immunodeficiency_Homo sapiens_hsa053401.50490378
17Parkinsons disease_Homo sapiens_hsa050121.45165585
18Olfactory transduction_Homo sapiens_hsa047401.39862141
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.31219095
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.30050858
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29746653
22Chemical carcinogenesis_Homo sapiens_hsa052041.26696347
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25562659
24Morphine addiction_Homo sapiens_hsa050321.24217751
25Nicotine addiction_Homo sapiens_hsa050331.22689227
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22539407
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.18052413
28Circadian rhythm_Homo sapiens_hsa047101.13028188
29Asthma_Homo sapiens_hsa053101.10419357
30Glutamatergic synapse_Homo sapiens_hsa047241.06662992
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06060543
32Cholinergic synapse_Homo sapiens_hsa047251.03302217
33Circadian entrainment_Homo sapiens_hsa047131.02810596
34Retinol metabolism_Homo sapiens_hsa008301.00877198
35Propanoate metabolism_Homo sapiens_hsa006400.99194549
36Serotonergic synapse_Homo sapiens_hsa047260.93626898
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93569395
38Huntingtons disease_Homo sapiens_hsa050160.92122466
39Peroxisome_Homo sapiens_hsa041460.91908094
40Graft-versus-host disease_Homo sapiens_hsa053320.90285878
41Sulfur relay system_Homo sapiens_hsa041220.88722925
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88422877
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86413470
44Alzheimers disease_Homo sapiens_hsa050100.86271761
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.86014212
46Dopaminergic synapse_Homo sapiens_hsa047280.85531115
47One carbon pool by folate_Homo sapiens_hsa006700.81785122
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75443965
49Non-homologous end-joining_Homo sapiens_hsa034500.74148035
50Proteasome_Homo sapiens_hsa030500.73121662
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72391808
52Insulin secretion_Homo sapiens_hsa049110.71913927
53Fructose and mannose metabolism_Homo sapiens_hsa000510.66576563
54Dorso-ventral axis formation_Homo sapiens_hsa043200.65894219
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65353964
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65058332
57ABC transporters_Homo sapiens_hsa020100.64963730
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59318972
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57650501
60Allograft rejection_Homo sapiens_hsa053300.56722832
61Metabolic pathways_Homo sapiens_hsa011000.56602255
62Rheumatoid arthritis_Homo sapiens_hsa053230.55493195
63Cardiac muscle contraction_Homo sapiens_hsa042600.54325380
64Sulfur metabolism_Homo sapiens_hsa009200.54166591
65Autoimmune thyroid disease_Homo sapiens_hsa053200.53661122
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52549813
67Purine metabolism_Homo sapiens_hsa002300.51563328
68Type I diabetes mellitus_Homo sapiens_hsa049400.50185575
69Oxytocin signaling pathway_Homo sapiens_hsa049210.50176214
70Renin secretion_Homo sapiens_hsa049240.49646352
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48931983
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48708845
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48079308
74Hematopoietic cell lineage_Homo sapiens_hsa046400.46807673
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46570705
76Salivary secretion_Homo sapiens_hsa049700.46570249
77Pyrimidine metabolism_Homo sapiens_hsa002400.44578314
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41449056
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41040307
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41005328
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40135678
82Collecting duct acid secretion_Homo sapiens_hsa049660.38790625
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38710610
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37228033
85Inositol phosphate metabolism_Homo sapiens_hsa005620.36853429
86Fatty acid elongation_Homo sapiens_hsa000620.36653340
87Taste transduction_Homo sapiens_hsa047420.36579716
88Histidine metabolism_Homo sapiens_hsa003400.36261661
89cAMP signaling pathway_Homo sapiens_hsa040240.35717777
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35302324
91Sphingolipid metabolism_Homo sapiens_hsa006000.33894776
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33640184
93African trypanosomiasis_Homo sapiens_hsa051430.32577089
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32453881
95Antigen processing and presentation_Homo sapiens_hsa046120.32254233
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.31703185
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30199965
98Vitamin digestion and absorption_Homo sapiens_hsa049770.29959857
99Dilated cardiomyopathy_Homo sapiens_hsa054140.29884829
100Long-term potentiation_Homo sapiens_hsa047200.29261215
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28491480
102Glycerolipid metabolism_Homo sapiens_hsa005610.28123176
103Calcium signaling pathway_Homo sapiens_hsa040200.27420258
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26923370
105Galactose metabolism_Homo sapiens_hsa000520.26764670
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24626669
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.24625986
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24522373
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24185251
110Linoleic acid metabolism_Homo sapiens_hsa005910.23485440
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.22935407
112Caffeine metabolism_Homo sapiens_hsa002320.22700668
113Alcoholism_Homo sapiens_hsa050340.22503407
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22344275
115Gastric acid secretion_Homo sapiens_hsa049710.22066483
116Cocaine addiction_Homo sapiens_hsa050300.21275577
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.21018682
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20792169
119Biosynthesis of amino acids_Homo sapiens_hsa012300.19847701
120Amphetamine addiction_Homo sapiens_hsa050310.19385800
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19303747
122Nitrogen metabolism_Homo sapiens_hsa009100.19240708
123Vitamin B6 metabolism_Homo sapiens_hsa007500.18065262
124GnRH signaling pathway_Homo sapiens_hsa049120.17855641
125mTOR signaling pathway_Homo sapiens_hsa041500.17348147
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.17193904
127Mineral absorption_Homo sapiens_hsa049780.17125379
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15999016
129Vibrio cholerae infection_Homo sapiens_hsa051100.15352381
130Chemokine signaling pathway_Homo sapiens_hsa040620.14663544
131RNA degradation_Homo sapiens_hsa030180.14171093
132Ras signaling pathway_Homo sapiens_hsa040140.13856477
133mRNA surveillance pathway_Homo sapiens_hsa030150.13400581
134Ether lipid metabolism_Homo sapiens_hsa005650.12233913
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.12149565
136Bile secretion_Homo sapiens_hsa049760.11983796
137Long-term depression_Homo sapiens_hsa047300.11946084
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.11847694
139Arginine biosynthesis_Homo sapiens_hsa002200.11711124
140Pancreatic secretion_Homo sapiens_hsa049720.11023469
141Glucagon signaling pathway_Homo sapiens_hsa049220.10658355
142HIF-1 signaling pathway_Homo sapiens_hsa040660.09928462
143Ovarian steroidogenesis_Homo sapiens_hsa049130.09049773
144MAPK signaling pathway_Homo sapiens_hsa040100.07816106
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07789100
146Type II diabetes mellitus_Homo sapiens_hsa049300.07732848
147AMPK signaling pathway_Homo sapiens_hsa041520.06533197
148Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06104665
149Choline metabolism in cancer_Homo sapiens_hsa052310.05773724
150Lysine degradation_Homo sapiens_hsa003100.05537900
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.05447620
152Regulation of autophagy_Homo sapiens_hsa041400.03668469
153Thyroid hormone synthesis_Homo sapiens_hsa049180.03560950
154Arachidonic acid metabolism_Homo sapiens_hsa005900.00729745
155Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.00669867
156Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.00595435

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