MPP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.33127858
2central nervous system myelination (GO:0022010)9.33127858
3ensheathment of neurons (GO:0007272)5.90000292
4axon ensheathment (GO:0008366)5.90000292
5myelination (GO:0042552)5.88329390
6fatty acid elongation (GO:0030497)5.64497776
7negative regulation of neurotransmitter secretion (GO:0046929)4.56606048
8long-chain fatty acid biosynthetic process (GO:0042759)4.39787712
9apical protein localization (GO:0045176)4.30445840
10eye photoreceptor cell differentiation (GO:0001754)4.17468972
11photoreceptor cell differentiation (GO:0046530)4.17468972
12glomerular visceral epithelial cell development (GO:0072015)4.12443422
13glycerophospholipid catabolic process (GO:0046475)4.11392429
14* asymmetric protein localization (GO:0008105)4.09263273
15virion attachment to host cell (GO:0019062)4.08608484
16adhesion of symbiont to host cell (GO:0044650)4.08608484
17* myelin maintenance (GO:0043217)4.01304716
18negative regulation of neurotransmitter transport (GO:0051589)4.00495892
19peripheral nervous system axon ensheathment (GO:0032292)3.92097621
20myelination in peripheral nervous system (GO:0022011)3.92097621
21negative regulation of protein localization to cell surface (GO:2000009)3.85454233
22glomerular epithelial cell development (GO:0072310)3.82507615
23glomerular basement membrane development (GO:0032836)3.81215182
24notochord development (GO:0030903)3.71296046
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.69449819
26cholesterol biosynthetic process (GO:0006695)3.65767912
27protein localization to endosome (GO:0036010)3.56746479
28hippo signaling (GO:0035329)3.55104151
29negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.54710700
30positive regulation of actin filament depolymerization (GO:0030836)3.49312908
31mitotic metaphase plate congression (GO:0007080)3.49162925
32oligodendrocyte differentiation (GO:0048709)3.45471277
33metaphase plate congression (GO:0051310)3.43509969
34import into cell (GO:0098657)3.36429405
35creatine metabolic process (GO:0006600)3.34376585
36response to redox state (GO:0051775)3.34023263
37nuclear pore complex assembly (GO:0051292)3.34020577
38peptidyl-tyrosine autophosphorylation (GO:0038083)3.34018186
39L-amino acid import (GO:0043092)3.31606196
40mitotic chromosome condensation (GO:0007076)3.30694910
41limb bud formation (GO:0060174)3.30195781
42paraxial mesoderm development (GO:0048339)3.26139807
43cell adhesion mediated by integrin (GO:0033627)3.20836587
44sterol biosynthetic process (GO:0016126)3.19275386
45astrocyte development (GO:0014002)3.15263196
46regulation of centriole replication (GO:0046599)3.13828010
47artery development (GO:0060840)3.04932653
48adhesion of symbiont to host (GO:0044406)3.01332421
49regulation of hippo signaling (GO:0035330)3.00669330
50magnesium ion transport (GO:0015693)3.00490775
51regulation of collateral sprouting (GO:0048670)2.99123708
52sister chromatid segregation (GO:0000819)2.96922609
53renal filtration (GO:0097205)2.95356446
54mesodermal cell differentiation (GO:0048333)2.95338317
55positive regulation of oligodendrocyte differentiation (GO:0048714)2.95209849
56nuclear pore organization (GO:0006999)2.94810124
57mitotic sister chromatid cohesion (GO:0007064)2.93817558
58lateral sprouting from an epithelium (GO:0060601)2.92232405
59mitotic sister chromatid segregation (GO:0000070)2.89955586
60regulation of mitotic spindle organization (GO:0060236)2.88016211
61substantia nigra development (GO:0021762)2.86683157
62embryonic foregut morphogenesis (GO:0048617)2.86247864
63glomerulus development (GO:0032835)2.86187961
64response to hepatocyte growth factor (GO:0035728)2.85504277
65cellular response to hepatocyte growth factor stimulus (GO:0035729)2.85504277
66presynaptic membrane assembly (GO:0097105)2.84670994
67glomerular filtration (GO:0003094)2.81895186
68cerebral cortex radially oriented cell migration (GO:0021799)2.81478182
69amyloid precursor protein metabolic process (GO:0042982)2.80030511
70presynaptic membrane organization (GO:0097090)2.77003958
71negative regulation of keratinocyte proliferation (GO:0010839)2.76735268
72Golgi to plasma membrane protein transport (GO:0043001)2.76106653
73platelet-derived growth factor receptor signaling pathway (GO:0048008)2.75179268
74glycosylceramide metabolic process (GO:0006677)2.74693506
75mitotic cytokinesis (GO:0000281)2.73676476
76NLS-bearing protein import into nucleus (GO:0006607)2.72941355
77regulation of transforming growth factor beta2 production (GO:0032909)2.72325133
78bundle of His cell to Purkinje myocyte communication (GO:0086069)2.69198690
79negative regulation of Rho protein signal transduction (GO:0035024)2.68685088
80isoprenoid biosynthetic process (GO:0008299)2.66422282
81neuron remodeling (GO:0016322)2.62857915
82regulation of lipoprotein metabolic process (GO:0050746)2.62646846
83long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.61602554
84protein localization to kinetochore (GO:0034501)2.60870315
85long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.57338661
86regulation of spindle organization (GO:0090224)2.56098519
87nerve growth factor signaling pathway (GO:0038180)2.55421832
88Rap protein signal transduction (GO:0032486)2.54193753
89anterior/posterior axis specification, embryo (GO:0008595)2.54099262
90amino acid import (GO:0043090)2.53084677
91retina vasculature morphogenesis in camera-type eye (GO:0061299)2.52960904
92establishment of chromosome localization (GO:0051303)2.52635883
93calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.52401974
94intestinal epithelial cell development (GO:0060576)2.51190090
95hemidesmosome assembly (GO:0031581)2.50768172
96response to lipoprotein particle (GO:0055094)2.49972869
97UDP-N-acetylglucosamine metabolic process (GO:0006047)2.48395129
98meiotic chromosome segregation (GO:0045132)2.48220430
99leukocyte migration involved in inflammatory response (GO:0002523)2.47906847
100regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.46444709
101dorsal/ventral axis specification (GO:0009950)2.45727932
102membrane tubulation (GO:0097320)2.45346373
103response to methylmercury (GO:0051597)2.44008854
104regulation of DNA endoreduplication (GO:0032875)2.41802775
105protein localization to chromosome, centromeric region (GO:0071459)2.41070120
106cytoskeleton-dependent cytokinesis (GO:0061640)2.39965886
107organ growth (GO:0035265)2.39482931
108Golgi to plasma membrane transport (GO:0006893)2.37780188
109branching involved in salivary gland morphogenesis (GO:0060445)2.36750977
110Golgi to endosome transport (GO:0006895)2.36243141
111mammary gland alveolus development (GO:0060749)2.36079876
112protein targeting to Golgi (GO:0000042)2.35999563
113positive regulation of neurological system process (GO:0031646)2.35372466
114cellular response to epinephrine stimulus (GO:0071872)2.34516104
115regulation of centrosome cycle (GO:0046605)2.34240202
116regulation of sister chromatid cohesion (GO:0007063)2.33987830
117regulation of cardioblast differentiation (GO:0051890)2.33940140
118membrane assembly (GO:0071709)2.33822649
119prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.33556142
120peripheral nervous system development (GO:0007422)2.32193173
121nucleotide transmembrane transport (GO:1901679)2.31820477
122otic vesicle formation (GO:0030916)2.31031867
123pore complex assembly (GO:0046931)2.30728649
124* tight junction assembly (GO:0070830)2.30331859
125regulation of centrosome duplication (GO:0010824)2.30294545
126microtubule polymerization or depolymerization (GO:0031109)2.28720251
127chondrocyte proliferation (GO:0035988)2.28258528
128regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.27983323
129Leydig cell differentiation (GO:0033327)2.27133511
130* cell-cell junction assembly (GO:0007043)2.27025395
131regulation of keratinocyte proliferation (GO:0010837)2.25845836
132epithelial tube branching involved in lung morphogenesis (GO:0060441)2.25509289
133interleukin-6-mediated signaling pathway (GO:0070102)2.25498607
134Sertoli cell development (GO:0060009)2.25206886
135positive regulation of glial cell differentiation (GO:0045687)2.24659465
136regulation of somitogenesis (GO:0014807)2.23542900
137negative regulation of axon extension involved in axon guidance (GO:0048843)2.23290522
138establishment of mitochondrion localization (GO:0051654)2.23099974
139negative regulation of axon guidance (GO:1902668)2.21147297
140negative regulation of JUN kinase activity (GO:0043508)2.21088855
141branch elongation of an epithelium (GO:0060602)2.20822533
142regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.20217337
143protein heterotetramerization (GO:0051290)2.20020617
144neurotransmitter catabolic process (GO:0042135)2.19660412
145ear development (GO:0043583)2.19460561
146positive regulation of gliogenesis (GO:0014015)2.18962926
147spindle assembly involved in mitosis (GO:0090307)2.14563058
148histone-serine phosphorylation (GO:0035404)2.13368334
149COPII vesicle coating (GO:0048208)2.12652478
150desmosome organization (GO:0002934)2.09710919
151kinetochore organization (GO:0051383)2.08650518
152negative regulation of vascular permeability (GO:0043116)2.07830499
153positive regulation of mitotic sister chromatid separation (GO:1901970)2.07717399
154positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.07717399
155positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.07717399
156ventricular cardiac muscle cell development (GO:0055015)2.07407810
157regulation of chromosome segregation (GO:0051983)2.06823060
158positive regulation of catenin import into nucleus (GO:0035413)2.06088184
159CENP-A containing nucleosome assembly (GO:0034080)2.05802043
160embryonic retina morphogenesis in camera-type eye (GO:0060059)2.05751373
161cellular protein complex localization (GO:0034629)2.03914260
162chromatin remodeling at centromere (GO:0031055)2.02464342
163regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.02297094
164positive regulation of chromosome segregation (GO:0051984)2.01604654
165chromosome condensation (GO:0030261)2.01488369
166positive regulation of cytokinesis (GO:0032467)1.99632353
167DNA unwinding involved in DNA replication (GO:0006268)1.99458244
168cytoplasmic mRNA processing body assembly (GO:0033962)1.98967015
169positive regulation of glycoprotein biosynthetic process (GO:0010560)1.98134080
170negative regulation of DNA repair (GO:0045738)1.97401476
171mesenchymal-epithelial cell signaling (GO:0060638)1.97213759
172radial glial cell differentiation (GO:0060019)1.96839918
173gap junction assembly (GO:0016264)1.94585033
174plasma membrane repair (GO:0001778)1.94298966
175attachment of spindle microtubules to kinetochore (GO:0008608)1.94088909
176branching involved in prostate gland morphogenesis (GO:0060442)1.93963017
177skin morphogenesis (GO:0043589)1.93544979
178midgut development (GO:0007494)1.93172965
179cell morphogenesis involved in neuron differentiation (GO:0048667)1.92924930
180negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)1.92460381
181fibroblast migration (GO:0010761)1.90983986
182ribosome assembly (GO:0042255)1.90904045
183resolution of meiotic recombination intermediates (GO:0000712)1.90299248
184regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.88878460
185negative regulation of chondrocyte differentiation (GO:0032331)1.88701139
186spindle checkpoint (GO:0031577)1.88404843
187negative regulation of hormone biosynthetic process (GO:0032353)1.88140833
188cellular response to vitamin D (GO:0071305)1.85752560
189mammary gland development (GO:0030879)1.85113204
190mitotic spindle organization (GO:0007052)1.84138871
191lymphangiogenesis (GO:0001946)1.82828899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1AR_21909140_ChIP-Seq_LNCAP_Human3.58136596
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.23424187
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.21745816
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.64706973
5GBX2_23144817_ChIP-Seq_PC3_Human2.53658862
6SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.49731517
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.29108941
8E2F7_22180533_ChIP-Seq_HELA_Human2.24448728
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15525482
10OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.13668883
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.11413559
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03553682
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99918620
14* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94040476
15EP300_21415370_ChIP-Seq_HL-1_Mouse1.87406716
16PIAS1_25552417_ChIP-Seq_VCAP_Human1.82975048
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.82742097
18TAF15_26573619_Chip-Seq_HEK293_Human1.79468041
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79268200
20WT1_19549856_ChIP-ChIP_CCG9911_Human1.78713950
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.78402304
22* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70962762
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69499453
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69285453
25ER_23166858_ChIP-Seq_MCF-7_Human1.69020797
26FUS_26573619_Chip-Seq_HEK293_Human1.68442326
27VDR_22108803_ChIP-Seq_LS180_Human1.66620053
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.66434732
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.66434732
30AR_21572438_ChIP-Seq_LNCaP_Human1.63243975
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60283850
32BRD4_25478319_ChIP-Seq_HGPS_Human1.58128985
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57755232
34TP53_16413492_ChIP-PET_HCT116_Human1.50634870
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.49793711
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.49575401
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47544995
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46556300
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46457097
40STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.46139938
41AHR_22903824_ChIP-Seq_MCF-7_Human1.46069745
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46051296
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45799330
44P300_19829295_ChIP-Seq_ESCs_Human1.44988181
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.44174846
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43401443
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43173104
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41201418
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40692207
50EZH2_22144423_ChIP-Seq_EOC_Human1.39599001
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.39387249
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38335461
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36369236
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.35772954
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35703159
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.35528719
57STAT3_23295773_ChIP-Seq_U87_Human1.35483958
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34991388
59SMAD4_21799915_ChIP-Seq_A2780_Human1.34679565
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34465018
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.31923547
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.31719452
63* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31674054
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31665735
65ELK1_19687146_ChIP-ChIP_HELA_Human1.31626237
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30671540
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30671540
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30487931
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29912533
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.29675489
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29556552
72* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28461864
73* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28461864
74CJUN_26792858_Chip-Seq_BT549_Human1.28052745
75FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27778363
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26802448
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.26488192
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.25540307
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24297323
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23579551
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23252984
82TP53_18474530_ChIP-ChIP_U2OS_Human1.21397432
83EWS_26573619_Chip-Seq_HEK293_Human1.20497643
84* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19504164
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.19172392
86SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17511723
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16963452
88* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16791441
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16704773
90CMYC_18555785_Chip-Seq_ESCs_Mouse1.16646054
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16525655
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16211325
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15767130
94TCF4_23295773_ChIP-Seq_U87_Human1.15424048
95SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14496418
96RNF2_27304074_Chip-Seq_ESCs_Mouse1.13760668
97EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12315493
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11912037
99TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11396424
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11299693
101TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11213917
102FLI1_27457419_Chip-Seq_LIVER_Mouse1.10643226
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.10214505
104WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10123613
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10084367
106PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09328278
107* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08685883
108SOX2_20726797_ChIP-Seq_SW620_Human1.08537733
109BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08371591
110RNF2_27304074_Chip-Seq_NSC_Mouse1.08300733
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08274765
112* CDX2_22108803_ChIP-Seq_LS180_Human1.08215065
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.08141902
114CDX2_20551321_ChIP-Seq_CACO-2_Human1.08088655
115CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07715838
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07344754
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.06909235
118YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05945188
119FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05920410
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05252360
121ESR2_21235772_ChIP-Seq_MCF-7_Human1.05184804
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03590734
123TP63_23658742_ChIP-Seq_EP156T_Human1.03427252
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03388037
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03135066
126SOX9_26525672_Chip-Seq_HEART_Mouse1.02902810
127P300_18555785_Chip-Seq_ESCs_Mouse1.02677486
128PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01830963
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01537845
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01311587
131PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00681317
132SOX17_20123909_ChIP-Seq_XEN_Mouse0.99483538
133PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97977049
134E2F1_21310950_ChIP-Seq_MCF-7_Human0.96591209
135CLOCK_20551151_ChIP-Seq_293T_Human0.93619910
136SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90476653
137IGF1R_20145208_ChIP-Seq_DFB_Human0.90384324
138CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89898068
139MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89107638
140* GATA4_25053715_ChIP-Seq_YYC3_Human0.89004105
141TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88425245

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane4.35747408
2MP0000920_abnormal_myelination4.15479915
3MP0010352_gastrointestinal_tract_polyps3.03719275
4MP0010678_abnormal_skin_adnexa2.91252398
5MP0005171_absent_coat_pigmentation2.69263894
6MP0004272_abnormal_basement_membrane2.61665823
7MP0004885_abnormal_endolymph2.59518850
8MP0003690_abnormal_glial_cell2.56986640
9MP0000383_abnormal_hair_follicle2.43753242
10MP0005623_abnormal_meninges_morphology2.43531172
11MP0004270_analgesia2.36863350
12MP0000462_abnormal_digestive_system2.34693729
13MP0000537_abnormal_urethra_morphology2.30171193
14MP0009384_cardiac_valve_regurgitation2.18716763
15MP0001299_abnormal_eye_distance/2.13050219
16MP0001485_abnormal_pinna_reflex2.12028966
17MP0004043_abnormal_pH_regulation2.10428651
18MP0005410_abnormal_fertilization2.09543583
19MP0003937_abnormal_limbs/digits/tail_de2.07871189
20MP0003136_yellow_coat_color2.04622032
21MP0004742_abnormal_vestibular_system1.96380142
22MP0003880_abnormal_central_pattern1.95021262
23MP0001346_abnormal_lacrimal_gland1.89920904
24MP0003634_abnormal_glial_cell1.86008366
25MP0003329_amyloid_beta_deposits1.77859039
26MP0009697_abnormal_copulation1.77457468
27MP0000778_abnormal_nervous_system1.76448421
28MP0010234_abnormal_vibrissa_follicle1.74588405
29MP0009053_abnormal_anal_canal1.73392505
30MP0001486_abnormal_startle_reflex1.71797536
31MP0003705_abnormal_hypodermis_morpholog1.69054385
32MP0002009_preneoplasia1.68174985
33MP0005257_abnormal_intraocular_pressure1.67148126
34MP0000566_synostosis1.62493437
35MP0003632_abnormal_nervous_system1.61905883
36MP0008057_abnormal_DNA_replication1.59843661
37MP0002295_abnormal_pulmonary_circulatio1.58410727
38MP0002697_abnormal_eye_size1.56214353
39MP0004134_abnormal_chest_morphology1.55877362
40MP0002234_abnormal_pharynx_morphology1.54450515
41MP0005248_abnormal_Harderian_gland1.53962554
42MP0005409_darkened_coat_color1.52563203
43MP0001293_anophthalmia1.46812795
44MP0000762_abnormal_tongue_morphology1.45616977
45MP0000428_abnormal_craniofacial_morphol1.44613597
46MP0003693_abnormal_embryo_hatching1.43568896
47MP0000569_abnormal_digit_pigmentation1.42908259
48MP0000467_abnormal_esophagus_morphology1.42373360
49MP0010030_abnormal_orbit_morphology1.42359984
50MP0005408_hypopigmentation1.40595783
51MP0009250_abnormal_appendicular_skeleto1.39699534
52MP0009780_abnormal_chondrocyte_physiolo1.38661635
53MP0004957_abnormal_blastocyst_morpholog1.38135586
54MP0005187_abnormal_penis_morphology1.35115755
55MP0000647_abnormal_sebaceous_gland1.30999927
56MP0004185_abnormal_adipocyte_glucose1.28535255
57MP0002084_abnormal_developmental_patter1.28112335
58MP0001879_abnormal_lymphatic_vessel1.28018232
59MP0003890_abnormal_embryonic-extraembry1.27647561
60MP0004036_abnormal_muscle_relaxation1.26856505
61MP0001286_abnormal_eye_development1.26775822
62MP0001177_atelectasis1.24933120
63MP0003566_abnormal_cell_adhesion1.24872150
64MP0008932_abnormal_embryonic_tissue1.22434307
65MP0002092_abnormal_eye_morphology1.19826705
66MP0001661_extended_life_span1.19127836
67MP0006054_spinal_hemorrhage1.19079977
68MP0005551_abnormal_eye_electrophysiolog1.18194952
69MP0003077_abnormal_cell_cycle1.17918474
70MP0002272_abnormal_nervous_system1.16965773
71MP0002229_neurodegeneration1.16641893
72MP0010094_abnormal_chromosome_stability1.14788779
73MP0002896_abnormal_bone_mineralization1.13301352
74MP0000747_muscle_weakness1.11027719
75MP0002938_white_spotting1.10309795
76MP0005023_abnormal_wound_healing1.08591870
77MP0001905_abnormal_dopamine_level1.05451393
78MP0003935_abnormal_craniofacial_develop1.04072102
79MP0001963_abnormal_hearing_physiology1.03747823
80MP0003868_abnormal_feces_composition1.03144100
81MP0005451_abnormal_body_composition1.01090005
82MP0002085_abnormal_embryonic_tissue1.00554197
83MP0008438_abnormal_cutaneous_collagen1.00282307
84MP0001958_emphysema0.99832286
85MP0002133_abnormal_respiratory_system0.99209578
86MP0005388_respiratory_system_phenotype0.99209578
87MP0008007_abnormal_cellular_replicative0.97311079
88MP0006138_congestive_heart_failure0.96701025
89MP0004233_abnormal_muscle_weight0.96429705
90MP0010307_abnormal_tumor_latency0.96102094
91MP0003631_nervous_system_phenotype0.94775569
92MP0001529_abnormal_vocalization0.93865003
93MP0008877_abnormal_DNA_methylation0.92942965
94MP0001666_abnormal_nutrient_absorption0.92787237
95MP0004215_abnormal_myocardial_fiber0.92441738
96MP0001851_eye_inflammation0.92227173
97MP0006292_abnormal_olfactory_placode0.92183666
98MP0004197_abnormal_fetal_growth/weight/0.92152230
99MP0000579_abnormal_nail_morphology0.91940084
100MP0001697_abnormal_embryo_size0.91683590
101MP0001672_abnormal_embryogenesis/_devel0.91238126
102MP0005380_embryogenesis_phenotype0.91238126
103MP0006072_abnormal_retinal_apoptosis0.91135480
104MP0004145_abnormal_muscle_electrophysio0.90800665
105MP0002108_abnormal_muscle_morphology0.90419034
106MP0000733_abnormal_muscle_development0.90034955
107MP0003755_abnormal_palate_morphology0.89187815
108MP0005195_abnormal_posterior_eye0.89182012
109MP0000627_abnormal_mammary_gland0.88503949
110MP0005085_abnormal_gallbladder_physiolo0.87583768
111MP0002282_abnormal_trachea_morphology0.87404092
112MP0003787_abnormal_imprinting0.86370552
113MP0010368_abnormal_lymphatic_system0.85970113
114MP0003111_abnormal_nucleus_morphology0.85710977
115MP0003942_abnormal_urinary_system0.85637435
116MP0003718_maternal_effect0.83879433
117MP0002233_abnormal_nose_morphology0.83553680
118MP0003385_abnormal_body_wall0.83514451
119MP0003984_embryonic_growth_retardation0.83377967
120MP0002877_abnormal_melanocyte_morpholog0.83150066
121MP0000613_abnormal_salivary_gland0.81553729
122MP0002111_abnormal_tail_morphology0.81491398
123MP0003941_abnormal_skin_development0.81203982
124MP0003938_abnormal_ear_development0.80724609
125MP0002882_abnormal_neuron_morphology0.80504877
126MP0002098_abnormal_vibrissa_morphology0.80425902
127MP0005391_vision/eye_phenotype0.80264964
128MP0002088_abnormal_embryonic_growth/wei0.79899521
129MP0003091_abnormal_cell_migration0.79333252
130MP0001730_embryonic_growth_arrest0.79026343
131MP0000749_muscle_degeneration0.78933382
132MP0002064_seizures0.78638303
133MP0002752_abnormal_somatic_nervous0.78580455
134MP0001440_abnormal_grooming_behavior0.78260608
135MP0001340_abnormal_eyelid_morphology0.77825807
136MP0003936_abnormal_reproductive_system0.77555414
137MP0000432_abnormal_head_morphology0.76941329
138MP0000604_amyloidosis0.76833253
139MP0002734_abnormal_mechanical_nocicepti0.76073770
140MP0009703_decreased_birth_body0.75985589
141MP0003861_abnormal_nervous_system0.75898285
142MP0002086_abnormal_extraembryonic_tissu0.75027344
143MP0005253_abnormal_eye_physiology0.74994801
144MP0000534_abnormal_ureter_morphology0.74392879
145MP0003453_abnormal_keratinocyte_physiol0.74338909
146MP0004084_abnormal_cardiac_muscle0.73956191
147MP0005503_abnormal_tendon_morphology0.73720713
148MP0000013_abnormal_adipose_tissue0.73502745
149MP0000377_abnormal_hair_follicle0.71958807
150MP0005395_other_phenotype0.70626930
151MP0005620_abnormal_muscle_contractility0.70471798
152MP0005501_abnormal_skin_physiology0.70441439
153MP0000026_abnormal_inner_ear0.70041366
154MP0000350_abnormal_cell_proliferation0.69864450
155MP0005076_abnormal_cell_differentiation0.69325594
156MP0005167_abnormal_blood-brain_barrier0.68628681
157MP0003252_abnormal_bile_duct0.67321086
158MP0003315_abnormal_perineum_morphology0.67211945
159MP0002160_abnormal_reproductive_system0.67098683
160MP0000003_abnormal_adipose_tissue0.65954419
161MP0000230_abnormal_systemic_arterial0.65948382
162MP0002972_abnormal_cardiac_muscle0.64749830
163MP0003300_gastrointestinal_ulcer0.61726018
164MP0003698_abnormal_male_reproductive0.61268732
165MP0003633_abnormal_nervous_system0.60966594
166MP0000427_abnormal_hair_cycle0.59510396

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.67617507
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.67617507
3Neurofibrillary tangles (HP:0002185)5.05715840
4Abnormality of the corticospinal tract (HP:0002492)3.91077136
5Sensory axonal neuropathy (HP:0003390)3.85743333
6Cerebral inclusion bodies (HP:0100314)3.59787631
7Peripheral hypomyelination (HP:0007182)3.38629359
8Increased circulating renin level (HP:0000848)3.33385188
9Abnormal auditory evoked potentials (HP:0006958)3.32248622
10Hypokalemic alkalosis (HP:0001949)3.24673085
11Termporal pattern (HP:0011008)3.24216651
12Insidious onset (HP:0003587)3.24216651
13Parakeratosis (HP:0001036)3.21096641
14Metabolic alkalosis (HP:0200114)3.17036871
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.12668773
16Aplasia involving bones of the upper limbs (HP:0009823)3.08322017
17Aplasia of the phalanges of the hand (HP:0009802)3.08322017
18Aplasia involving bones of the extremities (HP:0009825)3.08322017
19Focal segmental glomerulosclerosis (HP:0000097)3.05060220
20Onion bulb formation (HP:0003383)2.96818099
21Hyporeflexia of lower limbs (HP:0002600)2.79595902
22Alacrima (HP:0000522)2.77082064
23Hypoplasia of the iris (HP:0007676)2.74591392
24Intention tremor (HP:0002080)2.72069750
25Hypomagnesemia (HP:0002917)2.71183484
26Glomerulosclerosis (HP:0000096)2.59553904
27Muscle fiber splitting (HP:0003555)2.58935293
28Humeroradial synostosis (HP:0003041)2.56300488
29Synostosis involving the elbow (HP:0003938)2.56300488
30Abnormality of the phalanges of the 2nd finger (HP:0009541)2.53462496
31Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.52968741
32Papillary thyroid carcinoma (HP:0002895)2.50748075
33Autoamputation (HP:0001218)2.47661250
34Coronal craniosynostosis (HP:0004440)2.47154812
35Chromsome breakage (HP:0040012)2.47032071
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43991342
37Tubular atrophy (HP:0000092)2.35421206
38Metaphyseal dysplasia (HP:0100255)2.34654589
39Esophageal atresia (HP:0002032)2.34603577
40Spastic gait (HP:0002064)2.32572345
41Infantile muscular hypotonia (HP:0008947)2.31039128
42Short nail (HP:0001799)2.28863790
43Cupped ear (HP:0000378)2.28298644
44Abnormality of the middle phalanges of the toes (HP:0010183)2.27324891
45Premature skin wrinkling (HP:0100678)2.20619102
46Microglossia (HP:0000171)2.20537201
47White forelock (HP:0002211)2.17265541
48Akinesia (HP:0002304)2.14727910
49Thickened helices (HP:0000391)2.14520331
50Stage 5 chronic kidney disease (HP:0003774)2.13679532
51Segmental peripheral demyelination/remyelination (HP:0003481)2.12546566
52Decreased lacrimation (HP:0000633)2.11476359
53Intrahepatic cholestasis (HP:0001406)2.11249000
54Missing ribs (HP:0000921)2.10330862
55Dysmetria (HP:0001310)2.10054253
56Cerebral hemorrhage (HP:0001342)2.07753804
57Gowers sign (HP:0003391)2.07186569
58Morphological abnormality of the inner ear (HP:0011390)2.05512552
59Absent septum pellucidum (HP:0001331)2.04455688
60Anteriorly placed anus (HP:0001545)2.04257617
61Dynein arm defect of respiratory motile cilia (HP:0012255)2.03524089
62Absent/shortened dynein arms (HP:0200106)2.03524089
63Abnormal respiratory motile cilium physiology (HP:0012261)2.02772837
64Abnormality of the nasal septum (HP:0000419)2.01420305
65Chin dimple (HP:0010751)2.00469199
66Bell-shaped thorax (HP:0001591)2.00100127
67Abnormality of chloride homeostasis (HP:0011422)1.99820862
68Congenital ichthyosiform erythroderma (HP:0007431)1.98734301
69Hypoplastic pelvis (HP:0008839)1.98247038
70Patchy hypopigmentation of hair (HP:0011365)1.98130171
71Symphalangism affecting the phalanges of the hand (HP:0009773)1.97768615
72Genital tract atresia (HP:0001827)1.97149568
73Proximal tubulopathy (HP:0000114)1.96702979
74Adrenal hypoplasia (HP:0000835)1.96210881
75Short hallux (HP:0010109)1.94927126
76Vaginal atresia (HP:0000148)1.93615180
77Abnormality of the 2nd finger (HP:0004100)1.92857265
78Abnormal drinking behavior (HP:0030082)1.91929728
79Polydipsia (HP:0001959)1.91929728
80Clumsiness (HP:0002312)1.90315580
81Glioma (HP:0009733)1.89851271
82Congenital sensorineural hearing impairment (HP:0008527)1.89009755
83Stenosis of the external auditory canal (HP:0000402)1.89008692
84Right ventricular cardiomyopathy (HP:0011663)1.88286106
85Arterial tortuosity (HP:0005116)1.88176100
86Partial duplication of thumb phalanx (HP:0009944)1.88033582
87Astrocytoma (HP:0009592)1.87432966
88Abnormality of the astrocytes (HP:0100707)1.87432966
89Increased nuchal translucency (HP:0010880)1.86241513
90Muscle hypertrophy of the lower extremities (HP:0008968)1.85761532
91Retinal dysplasia (HP:0007973)1.84571769
92Buphthalmos (HP:0000557)1.84267830
93Abnormality of the distal phalanx of the thumb (HP:0009617)1.83759318
94Long nose (HP:0003189)1.83038701
95Vertebral hypoplasia (HP:0008417)1.82565208
96Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.82565208
97Hypoplastic labia majora (HP:0000059)1.82161422
98Osteolytic defects of the hand bones (HP:0009699)1.80696011
99Osteolytic defects of the phalanges of the hand (HP:0009771)1.80696011
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.80618466
101Vertebral clefting (HP:0008428)1.80367205
102Abnormality of the ischium (HP:0003174)1.78547343
103Hydroxyprolinuria (HP:0003080)1.77841400
104Abnormality of proline metabolism (HP:0010907)1.77841400
105Nonprogressive disorder (HP:0003680)1.76923115
106Difficulty running (HP:0009046)1.75893658
107Aplasia of the musculature (HP:0100854)1.75683774
108Cone-rod dystrophy (HP:0000548)1.75164291
109Lower limb muscle weakness (HP:0007340)1.74670430
110Supranuclear gaze palsy (HP:0000605)1.74609183
111Abnormality of the septum pellucidum (HP:0007375)1.74375850
112Abnormal ciliary motility (HP:0012262)1.73272971
113Mixed hearing impairment (HP:0000410)1.72864967
114Renal salt wasting (HP:0000127)1.72561744
115Abnormality of incisor morphology (HP:0011063)1.72499091
116Cystic hygroma (HP:0000476)1.72408722
117Barrel-shaped chest (HP:0001552)1.71957535
118Aplasia/Hypoplasia of the hallux (HP:0008362)1.71519549
119Hyperaldosteronism (HP:0000859)1.70257841
120Short tibia (HP:0005736)1.69705090
121Tubulointerstitial fibrosis (HP:0005576)1.68507148
122Vascular tortuosity (HP:0004948)1.67454907
123Partial duplication of the phalanx of hand (HP:0009999)1.66692953
124Steppage gait (HP:0003376)1.66674397
125Scanning speech (HP:0002168)1.66537083
126Relative macrocephaly (HP:0004482)1.66405802
127Cerebral hypomyelination (HP:0006808)1.65869977
128Abnormality of magnesium homeostasis (HP:0004921)1.65700308
129Pterygium (HP:0001059)1.65187635
130Shoulder girdle muscle weakness (HP:0003547)1.65173066
131Abnormality of the labia majora (HP:0012881)1.64702244
132Tibial bowing (HP:0002982)1.62880763
133Partial agenesis of the corpus callosum (HP:0001338)1.61789017
134Absent radius (HP:0003974)1.61307478
135Aplasia/Hypoplasia of the uvula (HP:0010293)1.61088640
136Large earlobe (HP:0009748)1.60765115
137Abnormal biliary tract morphology (HP:0012440)1.60714218
138Aplasia/Hypoplasia of the sternum (HP:0006714)1.60518248
139Chorioretinal atrophy (HP:0000533)1.60433302
140Neonatal short-limb short stature (HP:0008921)1.59532835
141Abnormality of the phalanges of the hallux (HP:0010057)1.58729466
142Aplasia involving forearm bones (HP:0009822)1.58398139
143Absent forearm bone (HP:0003953)1.58398139
144Biliary tract neoplasm (HP:0100574)1.57894237
145Limited hip movement (HP:0008800)1.57235146
146Cerebellar dysplasia (HP:0007033)1.56834611
147Median cleft lip (HP:0000161)1.56804900
148Abnormality of the proximal phalanges of the hand (HP:0009834)1.56611318
149Deep philtrum (HP:0002002)1.55064007
150Abnormality of chromosome stability (HP:0003220)1.54608216
151Ectopic kidney (HP:0000086)1.54599871
152Hypoplastic scapulae (HP:0000882)1.52395290
153Aplasia/Hypoplasia of the scapulae (HP:0006713)1.52395290
154Aplasia/Hypoplasia of the fibula (HP:0006492)1.52273710
155Vertebral arch anomaly (HP:0008438)1.52201456
156Duplication of thumb phalanx (HP:0009942)1.51891870
157Meckel diverticulum (HP:0002245)1.51127680
158Gastrointestinal atresia (HP:0002589)1.48766059
159Abnormal lung lobation (HP:0002101)1.47511486
160Volvulus (HP:0002580)1.47174083
161Abnormality of chromosome segregation (HP:0002916)1.46882269
162Abnormality of the antihelix (HP:0009738)1.46678783
163Abnormality of the carotid arteries (HP:0005344)1.46583024
164Abnormality of glutamine family amino acid metabolism (HP:0010902)1.46531778
165Cardiovascular calcification (HP:0011915)1.46298810
166Rhabdomyosarcoma (HP:0002859)1.45320955
167Curly hair (HP:0002212)1.44956286
168Natal tooth (HP:0000695)1.44711434
169High anterior hairline (HP:0009890)1.43817234
170Midline defect of the nose (HP:0004122)1.43145277
171Abnormality of the diencephalon (HP:0010662)1.40889736
172Ependymoma (HP:0002888)1.40662601
173Abnormality of the fibula (HP:0002991)1.39837177
174Fat malabsorption (HP:0002630)1.39364321
175Abnormality of the labia minora (HP:0012880)1.37508348
176Vascular calcification (HP:0004934)1.37245155
177Duodenal stenosis (HP:0100867)1.36736339
178Small intestinal stenosis (HP:0012848)1.36736339
17911 pairs of ribs (HP:0000878)1.36647305
180Heterotopia (HP:0002282)1.36462517
181Nemaline bodies (HP:0003798)1.36181231
182Abnormality of the musculature of the pelvis (HP:0001469)1.35996446
183Abnormality of the hip-girdle musculature (HP:0001445)1.35996446
184Hypoplastic ischia (HP:0003175)1.35635595
185Hypobetalipoproteinemia (HP:0003563)1.35194905
186Central scotoma (HP:0000603)1.35184646
187Fibular hypoplasia (HP:0003038)1.35164404
188Capillary hemangiomas (HP:0005306)1.34492913
189Bundle branch block (HP:0011710)1.34378914
190Preaxial foot polydactyly (HP:0001841)1.34376705
191Abnormality of the ileum (HP:0001549)1.33559299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.71013108
2OXSR14.49853116
3WNK43.36363535
4EPHB12.89771603
5FGFR22.59739156
6BCR2.54008678
7MST42.47256997
8WEE12.41043027
9TSSK62.36476060
10MET2.33284255
11LATS12.25191660
12PBK2.22358759
13BRSK22.21836738
14NUAK12.20532968
15NEK62.13802471
16ACVR1B2.00495947
17PKN12.00179361
18NEK11.98661730
19LATS21.92023970
20TTK1.83976546
21BUB11.78562573
22WNK11.76400625
23EIF2AK11.75942437
24DMPK1.63777210
25FRK1.59734150
26EIF2AK31.57165770
27MKNK21.56223472
28TIE11.49542597
29PTK21.46920193
30PIK3CA1.46525337
31MAPKAPK51.45245963
32LIMK11.45186488
33PLK31.42558023
34NEK91.36539907
35ROCK21.36383658
36CSNK1A1L1.30074423
37PDGFRA1.24400769
38NTRK11.23111514
39MAP3K121.23065152
40ERBB31.18837605
41ERBB41.17890630
42SGK2231.17628315
43SGK4941.17628315
44MUSK1.16119054
45OBSCN1.13388552
46PDK21.13156467
47PAK31.12756315
48ICK1.09868590
49PLK41.08934581
50PLK11.08617731
51CSNK1G11.07971415
52PNCK1.07203329
53CSNK1G31.06712494
54MKNK11.05927682
55CAMK2B1.05791717
56FGR1.03688831
57CAMK1G1.03581520
58BRSK11.03551243
59PRPF4B1.02825325
60EPHB21.02150424
61CDC70.98187128
62CSNK1G20.96903853
63TYRO30.93529201
64SCYL20.92847205
65STK38L0.90837415
66TRPM70.90528655
67CASK0.89810678
68AURKB0.89157398
69BRD40.89110053
70TNIK0.88222338
71CAMK2D0.87048374
72STK30.85110577
73MELK0.83770824
74SRPK10.83401945
75PRKD30.82732509
76PDGFRB0.81114418
77KSR10.80736378
78PRKCQ0.80165642
79TAF10.76519408
80FER0.75621465
81FGFR10.73134835
82MAP3K40.72687470
83PDPK10.70404245
84EIF2AK20.69411476
85PRKCE0.69376590
86ROCK10.69338554
87CDK80.68744396
88CDK120.66620208
89STK240.66401756
90WNK30.65951655
91BMPR1B0.65149072
92PAK40.64970463
93EPHA20.64559943
94PAK60.64429376
95MOS0.62980995
96NEK20.62792362
97MAP3K90.60835313
98STK380.60770042
99CHEK20.60632519
100GSK3A0.60388280
101CLK10.60175423
102MAP3K20.57583691
103CAMK2A0.57553937
104PTK2B0.57551141
105CAMK1D0.52831894
106LMTK20.50965373
107CAMK2G0.50823739
108STK110.49034601
109TTN0.48636019
110RIPK10.48346327
111PRKD10.48321358
112CDK140.47244011
113MST1R0.46733729
114CSNK1D0.46644173
115MYLK0.45005471
116CHEK10.44773280
117CSNK1E0.44488614
118UHMK10.44450464
119AKT30.44370480
120MAPK150.43332545
121PHKG20.42824920
122PHKG10.42824920
123PLK20.42613502
124YES10.42595603
125PRKG10.42454583
126GRK10.42371755
127ATM0.42248041
128TRIM280.40041713
129PRKCI0.38894675
130CDK50.38809077
131INSR0.38387351
132SGK10.37043307
133CDK60.36409066
134TGFBR10.36207293
135PRKACB0.35795913
136INSRR0.35769511
137PDK30.35602417
138PDK40.35602417
139RPS6KA50.35426914
140CDK150.33518509
141IRAK20.33510569
142BMX0.33393542
143EPHA40.33336364
144DYRK20.33046724
145STK100.32234685
146FYN0.32145445
147PAK20.32071446
148PDK10.31586216
149MAPK100.29905528
150CDK190.29003285
151CDK180.28962158
152MAPK130.28774254
153ABL10.27898258
154IRAK10.27755837

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.99694012
2Steroid biosynthesis_Homo sapiens_hsa001003.80406495
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.04711285
4Ether lipid metabolism_Homo sapiens_hsa005652.91169474
5Fatty acid elongation_Homo sapiens_hsa000622.76428677
6Sulfur metabolism_Homo sapiens_hsa009202.65797540
7Sphingolipid metabolism_Homo sapiens_hsa006002.08880126
8* Tight junction_Homo sapiens_hsa045302.00984331
9Axon guidance_Homo sapiens_hsa043601.96757053
10Linoleic acid metabolism_Homo sapiens_hsa005911.70407931
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68417619
12ECM-receptor interaction_Homo sapiens_hsa045121.63332960
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62660299
14Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.62370212
15Cell cycle_Homo sapiens_hsa041101.54714075
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.51259158
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47099260
18Caffeine metabolism_Homo sapiens_hsa002321.45896894
19Dorso-ventral axis formation_Homo sapiens_hsa043201.44348537
20Circadian rhythm_Homo sapiens_hsa047101.43914326
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43461525
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42278705
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41963773
24Protein export_Homo sapiens_hsa030601.38006649
25Renal cell carcinoma_Homo sapiens_hsa052111.35811139
26Nitrogen metabolism_Homo sapiens_hsa009101.35022376
27Mineral absorption_Homo sapiens_hsa049781.32675471
28Fanconi anemia pathway_Homo sapiens_hsa034601.31646650
29Selenocompound metabolism_Homo sapiens_hsa004501.30533907
30Folate biosynthesis_Homo sapiens_hsa007901.29216112
31Histidine metabolism_Homo sapiens_hsa003401.28125161
32Ovarian steroidogenesis_Homo sapiens_hsa049131.24937359
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22191003
34Mismatch repair_Homo sapiens_hsa034301.21012335
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19377395
36Vitamin B6 metabolism_Homo sapiens_hsa007501.19134226
37Butanoate metabolism_Homo sapiens_hsa006501.18271163
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18175262
39Non-homologous end-joining_Homo sapiens_hsa034501.17321438
40p53 signaling pathway_Homo sapiens_hsa041151.13895563
41Pyruvate metabolism_Homo sapiens_hsa006201.13611041
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.13285081
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.09344548
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08413548
45Serotonergic synapse_Homo sapiens_hsa047261.07923173
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06085650
47Nucleotide excision repair_Homo sapiens_hsa034201.03509482
48RNA transport_Homo sapiens_hsa030131.03349715
49Basal transcription factors_Homo sapiens_hsa030221.02795253
50Focal adhesion_Homo sapiens_hsa045101.02545696
51Long-term depression_Homo sapiens_hsa047301.00600937
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00582556
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00418852
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99541105
55Vitamin digestion and absorption_Homo sapiens_hsa049770.99321771
56Lysine degradation_Homo sapiens_hsa003100.96735681
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96538951
58Adherens junction_Homo sapiens_hsa045200.95811938
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94847752
60* Hippo signaling pathway_Homo sapiens_hsa043900.93908837
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92533990
62Ras signaling pathway_Homo sapiens_hsa040140.92506345
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92350278
64Gastric acid secretion_Homo sapiens_hsa049710.91181688
65Arachidonic acid metabolism_Homo sapiens_hsa005900.90686275
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90613535
67TGF-beta signaling pathway_Homo sapiens_hsa043500.88804962
68Protein digestion and absorption_Homo sapiens_hsa049740.86552002
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86545866
70Arginine biosynthesis_Homo sapiens_hsa002200.86399378
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.86364742
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.85852041
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.85272409
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85118549
75Renin-angiotensin system_Homo sapiens_hsa046140.84500363
76Glutamatergic synapse_Homo sapiens_hsa047240.84406505
77Vibrio cholerae infection_Homo sapiens_hsa051100.83288843
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82035015
79Tryptophan metabolism_Homo sapiens_hsa003800.81562648
80Oocyte meiosis_Homo sapiens_hsa041140.81484290
81Dilated cardiomyopathy_Homo sapiens_hsa054140.80795559
82Thyroid cancer_Homo sapiens_hsa052160.79586115
83beta-Alanine metabolism_Homo sapiens_hsa004100.78717702
84Small cell lung cancer_Homo sapiens_hsa052220.77902425
85Endocytosis_Homo sapiens_hsa041440.77839732
86Salivary secretion_Homo sapiens_hsa049700.77503352
87Choline metabolism in cancer_Homo sapiens_hsa052310.76938712
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.74625005
89Hedgehog signaling pathway_Homo sapiens_hsa043400.74214386
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.73786079
91ErbB signaling pathway_Homo sapiens_hsa040120.72298716
92Pancreatic secretion_Homo sapiens_hsa049720.71845838
93Renin secretion_Homo sapiens_hsa049240.71108167
94Glutathione metabolism_Homo sapiens_hsa004800.70083097
95Thyroid hormone synthesis_Homo sapiens_hsa049180.69703149
96Arginine and proline metabolism_Homo sapiens_hsa003300.69380418
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69212235
98Starch and sucrose metabolism_Homo sapiens_hsa005000.68889954
99Fat digestion and absorption_Homo sapiens_hsa049750.68190844
100Propanoate metabolism_Homo sapiens_hsa006400.67787429
101Fatty acid biosynthesis_Homo sapiens_hsa000610.67374544
102Wnt signaling pathway_Homo sapiens_hsa043100.66741441
103GABAergic synapse_Homo sapiens_hsa047270.66461577
104Retinol metabolism_Homo sapiens_hsa008300.66342945
105One carbon pool by folate_Homo sapiens_hsa006700.65877465
106Collecting duct acid secretion_Homo sapiens_hsa049660.64564327
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64374296
108Melanoma_Homo sapiens_hsa052180.64097384
109Phototransduction_Homo sapiens_hsa047440.64088803
110Prostate cancer_Homo sapiens_hsa052150.63769002
111Oxidative phosphorylation_Homo sapiens_hsa001900.63516948
112Fatty acid degradation_Homo sapiens_hsa000710.63110237
113Rheumatoid arthritis_Homo sapiens_hsa053230.63040027
114DNA replication_Homo sapiens_hsa030300.62743060
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61415495
116Proteoglycans in cancer_Homo sapiens_hsa052050.58717517
117Gap junction_Homo sapiens_hsa045400.58256037
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.56446876
119Melanogenesis_Homo sapiens_hsa049160.56263888
120Rap1 signaling pathway_Homo sapiens_hsa040150.55807062
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54005236
122Homologous recombination_Homo sapiens_hsa034400.53711798
123Amoebiasis_Homo sapiens_hsa051460.53313222
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53203232
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52239977
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51775196
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51615552
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51297457
129mRNA surveillance pathway_Homo sapiens_hsa030150.50446800
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50281541
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50144095
132Cholinergic synapse_Homo sapiens_hsa047250.50001594
133Glucagon signaling pathway_Homo sapiens_hsa049220.49835581
134Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49216701
135Basal cell carcinoma_Homo sapiens_hsa052170.48463847
136MicroRNAs in cancer_Homo sapiens_hsa052060.47792520
137Fatty acid metabolism_Homo sapiens_hsa012120.47684873
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47329459
139Alzheimers disease_Homo sapiens_hsa050100.47084196
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47035154
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.45695021
142Oxytocin signaling pathway_Homo sapiens_hsa049210.45331847
143Circadian entrainment_Homo sapiens_hsa047130.43845800
144MAPK signaling pathway_Homo sapiens_hsa040100.43604577
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.42832057
146Morphine addiction_Homo sapiens_hsa050320.41837310
147Bile secretion_Homo sapiens_hsa049760.41481771
148cAMP signaling pathway_Homo sapiens_hsa040240.40915945
149Pathways in cancer_Homo sapiens_hsa052000.39617667
150GnRH signaling pathway_Homo sapiens_hsa049120.39532659
151Phagosome_Homo sapiens_hsa041450.38664299

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