MPP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins, which function in the establishment of epithelial cell polarity. This family member forms a complex with the polarity protein DLG1 (discs, large homolog 1) and facilitates epithelial cell polarity and tight junction formation. Polymorphisms in this gene are associated with variations in site-specific bone mineral density (BMD). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)4.89142961
2desmosome organization (GO:0002934)4.66884265
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.37566096
4negative regulation of neurotransmitter secretion (GO:0046929)4.18875886
5induction of positive chemotaxis (GO:0050930)4.08954456
6early endosome to late endosome transport (GO:0045022)4.05431037
7keratinocyte development (GO:0003334)4.04981805
8iron ion import (GO:0097286)3.99788530
9establishment of skin barrier (GO:0061436)3.95735407
10negative regulation of DNA-dependent DNA replication (GO:2000104)3.85222003
11regulation of water loss via skin (GO:0033561)3.82245569
12response to peptidoglycan (GO:0032494)3.77856752
13neutrophil activation (GO:0042119)3.70637305
14replicative senescence (GO:0090399)3.69773919
15phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.56402021
16detection of bacterium (GO:0016045)3.37260171
17prostate gland growth (GO:0060736)3.36870906
18intestinal epithelial cell development (GO:0060576)3.23005044
19detection of other organism (GO:0098543)3.22536498
20interferon-gamma secretion (GO:0072643)3.20695438
21surfactant homeostasis (GO:0043129)3.20184686
22phospholipid scrambling (GO:0017121)3.19493609
23water homeostasis (GO:0030104)3.17952590
24positive regulation of positive chemotaxis (GO:0050927)3.16676638
25granulocyte activation (GO:0036230)3.08574029
26striated muscle atrophy (GO:0014891)3.05642813
27epithelial cell maturation (GO:0002070)3.04928336
28dendritic cell chemotaxis (GO:0002407)3.02142454
29skeletal muscle adaptation (GO:0043501)3.01759879
30valine metabolic process (GO:0006573)3.01399684
31regulation of positive chemotaxis (GO:0050926)3.01326150
32hypotonic response (GO:0006971)2.99385929
33substrate-dependent cell migration (GO:0006929)2.97667458
34nodal signaling pathway (GO:0038092)2.95545872
35wound healing, spreading of epidermal cells (GO:0035313)2.95291999
36response to UV-B (GO:0010224)2.95015947
37peptidyl-threonine dephosphorylation (GO:0035970)2.94596097
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93923683
39negative regulation of cell killing (GO:0031342)2.93923683
40keratinocyte differentiation (GO:0030216)2.92197617
41protein targeting to Golgi (GO:0000042)2.92168838
42regulation of glomerular filtration (GO:0003093)2.91007384
43establishment of protein localization to Golgi (GO:0072600)2.90494667
44protein localization to kinetochore (GO:0034501)2.88190630
45dendritic cell migration (GO:0036336)2.84684813
46retrograde transport, vesicle recycling within Golgi (GO:0000301)2.84096491
47peptide catabolic process (GO:0043171)2.83381469
48regulation of gamma-delta T cell differentiation (GO:0045586)2.83027807
49regulation of gamma-delta T cell activation (GO:0046643)2.82668573
50histone H3-K36 demethylation (GO:0070544)2.81330047
51Golgi to endosome transport (GO:0006895)2.79915001
52positive regulation of monocyte chemotaxis (GO:0090026)2.78638963
53gland morphogenesis (GO:0022612)2.78365213
54notochord development (GO:0030903)2.77614522
55regulation of helicase activity (GO:0051095)2.77605054
56nuclear pore complex assembly (GO:0051292)2.76110687
57growth hormone receptor signaling pathway (GO:0060396)2.75140367
58regulation of pigment cell differentiation (GO:0050932)2.74728515
59regulation of interleukin-8 secretion (GO:2000482)2.74105208
60cellular response to interleukin-6 (GO:0071354)2.71923682
61cyclooxygenase pathway (GO:0019371)2.71517941
62negative regulation of glycoprotein biosynthetic process (GO:0010561)2.70887750
63positive regulation of granulocyte differentiation (GO:0030854)2.70537706
64negative regulation of neurotransmitter transport (GO:0051589)2.70399310
65negative regulation of keratinocyte proliferation (GO:0010839)2.69876961
66positive regulation of endothelial cell apoptotic process (GO:2000353)2.67725192
67superoxide anion generation (GO:0042554)2.67625175
68muscle atrophy (GO:0014889)2.67384477
69sphingoid metabolic process (GO:0046519)2.67318201
70hemidesmosome assembly (GO:0031581)2.65299404
71T-helper cell differentiation (GO:0042093)2.64946899
72CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.64946899
73regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.64117911
74multicellular organismal water homeostasis (GO:0050891)2.62934649
75amino-acid betaine transport (GO:0015838)2.62473736
76carnitine transport (GO:0015879)2.62473736
77citrulline biosynthetic process (GO:0019240)2.62335665
78keratinization (GO:0031424)2.62189667
79interkinetic nuclear migration (GO:0022027)2.62142860
80negative regulation of complement activation (GO:0045916)2.62055743
81pore complex assembly (GO:0046931)2.59470179
82positive regulation of gamma-delta T cell activation (GO:0046645)2.59358550
83negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.59246190
84positive regulation of insulin receptor signaling pathway (GO:0046628)2.55777524
85sphingomyelin metabolic process (GO:0006684)2.55645614
86JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.55411755
87negative regulation of humoral immune response (GO:0002921)2.55323251
88negative regulation of T cell mediated immunity (GO:0002710)2.54930988
89cellular polysaccharide catabolic process (GO:0044247)2.54461327
90embryonic process involved in female pregnancy (GO:0060136)2.53411917
91ribosomal small subunit assembly (GO:0000028)2.53052685
92definitive hemopoiesis (GO:0060216)2.52391901
93protein K11-linked deubiquitination (GO:0035871)2.51440141
94regulation of chemokine secretion (GO:0090196)2.51390265
95ventricular cardiac muscle cell action potential (GO:0086005)2.51379145
96regulation of keratinocyte differentiation (GO:0045616)2.51134092
97brown fat cell differentiation (GO:0050873)2.49925181
98neutrophil mediated immunity (GO:0002446)2.49825948
99histone H3-K4 trimethylation (GO:0080182)2.49494379
100negative regulation of lymphocyte mediated immunity (GO:0002707)2.47733196
101hepatocyte apoptotic process (GO:0097284)2.47657503
102regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.46298177
103interleukin-6-mediated signaling pathway (GO:0070102)2.45646379
104regulation of integrin-mediated signaling pathway (GO:2001044)2.45447107
105negative regulation of smooth muscle cell differentiation (GO:0051151)2.44753340
106regulation of acyl-CoA biosynthetic process (GO:0050812)2.42996520
107regulation of cell fate specification (GO:0042659)2.42949581
108carnitine transmembrane transport (GO:1902603)2.42856222
109positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.42762735
110bundle of His cell to Purkinje myocyte communication (GO:0086069)2.42430980
111glucan catabolic process (GO:0009251)2.41029739
112regulation of membrane lipid distribution (GO:0097035)2.40745808
113regulation of establishment of cell polarity (GO:2000114)2.40690079
114response to interleukin-6 (GO:0070741)2.40578936
115nuclear pore organization (GO:0006999)2.40327707
116regulation of B cell receptor signaling pathway (GO:0050855)2.39504318
117chemical homeostasis within a tissue (GO:0048875)2.39410475
118regulation of nuclear cell cycle DNA replication (GO:0033262)2.39210569
119macrophage activation involved in immune response (GO:0002281)2.39020817
120cellular response to vitamin (GO:0071295)2.38697297
121regulation of histone H3-K27 methylation (GO:0061085)2.38691357
122ovulation (GO:0030728)2.38594261
123negative regulation of gluconeogenesis (GO:0045721)2.38074021
124microglial cell activation (GO:0001774)2.38049885
125cellular carbohydrate catabolic process (GO:0044275)2.37795095
126detection of molecule of bacterial origin (GO:0032490)2.37298279
127positive regulation of interleukin-8 secretion (GO:2000484)2.36730355
128cellular extravasation (GO:0045123)2.36699057
129regulation of interferon-beta biosynthetic process (GO:0045357)2.36641164
130diol metabolic process (GO:0034311)2.35841040
131epidermal cell differentiation (GO:0009913)2.34960555
132positive regulation of regulated secretory pathway (GO:1903307)2.34577726
133response to muramyl dipeptide (GO:0032495)2.34054579
134protein K48-linked deubiquitination (GO:0071108)2.33653174
135tyrosine phosphorylation of STAT protein (GO:0007260)2.33445047
136positive regulation of leukocyte degranulation (GO:0043302)2.33223332
137NLS-bearing protein import into nucleus (GO:0006607)2.33082303
138ovulation from ovarian follicle (GO:0001542)2.33037018
139regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.33026985
140CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.32149821
141pyrimidine-containing compound transmembrane transport (GO:0072531)2.31468612
142sphingosine metabolic process (GO:0006670)2.30807196
143intra-S DNA damage checkpoint (GO:0031573)2.30729570
144positive regulation of Cdc42 GTPase activity (GO:0043089)2.30030581
145T cell lineage commitment (GO:0002360)2.29918231
146negative regulation of lipid storage (GO:0010888)2.29899276
147meiotic chromosome segregation (GO:0045132)2.27911793
148cellular response to ATP (GO:0071318)2.27689067
149negative regulation of granulocyte differentiation (GO:0030853)2.27401555
150regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.26920042
151regulation of hexokinase activity (GO:1903299)2.24135740
152regulation of glucokinase activity (GO:0033131)2.24135740
153calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.23257477
154* tight junction assembly (GO:0070830)2.23033788
155embryonic camera-type eye morphogenesis (GO:0048596)2.21885915
156cardiac right ventricle morphogenesis (GO:0003215)2.21271729
157columnar/cuboidal epithelial cell development (GO:0002066)2.20227997
158response to progesterone (GO:0032570)2.20032334
159regulation of establishment or maintenance of cell polarity (GO:0032878)2.18780704
160positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.18234337
161DNA integration (GO:0015074)2.18008659
162keratinocyte proliferation (GO:0043616)2.17336435
163molting cycle (GO:0042303)2.17118490
164hair cycle (GO:0042633)2.17118490
165cellular response to growth hormone stimulus (GO:0071378)2.16356295
166G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.16206576
167myoblast migration (GO:0051451)2.15811044
168detection of external biotic stimulus (GO:0098581)2.15403595
169negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.14887782
170determination of adult lifespan (GO:0008340)2.14634514
171negative regulation of cell fate specification (GO:0009996)2.14610150
172negative regulation of stress fiber assembly (GO:0051497)2.14122877
173renal system process involved in regulation of blood volume (GO:0001977)2.13815717
174regulation of natural killer cell differentiation (GO:0032823)2.13058759

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.86630135
2E2F7_22180533_ChIP-Seq_HELA_Human5.07683172
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.89631211
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.37977122
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.38624162
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.00626536
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.77340649
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.64809818
9STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.37199969
10SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.15148596
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.15148596
12FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.15128770
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.11080072
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.01791810
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.93771242
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.93771242
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.93771242
18TP63_19390658_ChIP-ChIP_HaCaT_Human1.83190057
19* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.81453154
20ARNT_22903824_ChIP-Seq_MCF-7_Human1.79642052
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76010230
22IGF1R_20145208_ChIP-Seq_DFB_Human1.71167828
23IRF8_27001747_Chip-Seq_BMDM_Mouse1.69505510
24SALL4_18804426_ChIP-ChIP_XEN_Mouse1.67809001
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66033019
26FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.65717031
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63507201
28GATA1_22025678_ChIP-Seq_K562_Human1.63480839
29ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62963865
30GATA4_25053715_ChIP-Seq_YYC3_Human1.62259121
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60043606
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57608895
33* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57604361
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.57471479
35SOX2_20726797_ChIP-Seq_SW620_Human1.57351621
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.56596423
37TCF3_18692474_ChIP-Seq_MEFs_Mouse1.55584118
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55559044
39ER_23166858_ChIP-Seq_MCF-7_Human1.50999688
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50776631
41CDX2_20551321_ChIP-Seq_CACO-2_Human1.50052872
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50052842
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48678204
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.47345920
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47192065
46RUNX_20019798_ChIP-Seq_JUKART_Human1.46895902
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46096099
48AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.44651000
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44169267
50* GATA3_24758297_ChIP-Seq_MCF-7_Human1.43615028
51ELK1_19687146_ChIP-ChIP_HELA_Human1.41475671
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.41024461
53* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.38140334
54TCF4_18268006_ChIP-ChIP_LS174T_Human1.35737688
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.34821310
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34045751
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29345803
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29345803
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29157136
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.28487671
61TCF3_18692474_ChIP-Seq_MESCs_Mouse1.28446675
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.27219456
63CDX2_22108803_ChIP-Seq_LS180_Human1.25341129
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24911024
65* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24421926
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23230402
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.22925505
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.22363246
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20827911
70* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19714646
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19693922
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19316758
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18703261
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17045342
75* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16647495
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.16387184
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16064196
78MYB_26560356_Chip-Seq_TH2_Human1.15021612
79* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.14853298
80GATA6_25053715_ChIP-Seq_YYC3_Human1.14681877
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14142731
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13260486
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12197873
84CJUN_26792858_Chip-Seq_BT549_Human1.11741175
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10925237
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.10898938
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10822638
88AR_21909140_ChIP-Seq_LNCAP_Human1.10634022
89* PU_27001747_Chip-Seq_BMDM_Mouse1.10563751
90TRIM28_21343339_ChIP-Seq_HEK293_Human1.09609461
91ELF5_23300383_ChIP-Seq_T47D_Human1.09328445
92TAF15_26573619_Chip-Seq_HEK293_Human1.09221830
93FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07875844
94EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07625019
95AHR_22903824_ChIP-Seq_MCF-7_Human1.07271731
96* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06825925
97CLOCK_20551151_ChIP-Seq_293T_Human1.06428919
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06403148
99LXR_22158963_ChIP-Seq_LIVER_Mouse1.04538345
100GATA3_27048872_Chip-Seq_THYMUS_Human1.04368204
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03628137
102GATA3_26560356_Chip-Seq_TH2_Human1.03338048
103BRD4_25478319_ChIP-Seq_HGPS_Human1.02280908
104PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01378176
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01043923
106SPI1_23547873_ChIP-Seq_NB4_Human1.00946380
107NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00653626
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99041712
109MYB_26560356_Chip-Seq_TH1_Human0.98178372
110SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97443785
111CHD1_26751641_Chip-Seq_LNCaP_Human0.97201012
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97156112
113* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97022054
114SCL_19346495_ChIP-Seq_HPC-7_Human0.96022683
115* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95887418
116SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95779229
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.95736099
118GATA2_19941826_ChIP-Seq_K562_Human0.93094389
119FOXA2_19822575_ChIP-Seq_HepG2_Human0.92750623
120ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92725682
121ESR1_20079471_ChIP-ChIP_T-47D_Human0.92686676
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92405623
123GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92289865
124FUS_26573619_Chip-Seq_HEK293_Human0.92175107
125GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91584054
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91489975
127* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91454366
128FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91200010
129FOXA1_25552417_ChIP-Seq_VCAP_Human0.90495344
130TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89250390
131FOXM1_23109430_ChIP-Seq_U2OS_Human0.89126383
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88913832
133PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85992226
134NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85983147
135NANOG_16153702_ChIP-ChIP_HESCs_Human0.84917195
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82840840
137TP63_23658742_ChIP-Seq_EP156T_Human0.82413362
138NFE2_27457419_Chip-Seq_LIVER_Mouse0.81915195
139ELK1_22589737_ChIP-Seq_MCF10A_Human0.81708224
140RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81199322
141SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81115933
142KLF5_25053715_ChIP-Seq_YYC3_Human0.80856337
143* TP53_18474530_ChIP-ChIP_U2OS_Human0.79859263
144SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.79429842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development3.77388035
2MP0002254_reproductive_system_inflammat3.37396434
3MP0002796_impaired_skin_barrier3.29675163
4MP0008057_abnormal_DNA_replication2.76524525
5MP0010368_abnormal_lymphatic_system2.72001392
6MP0008961_abnormal_basal_metabolism2.57750820
7MP0002009_preneoplasia2.44289143
8MP0003656_abnormal_erythrocyte_physiolo2.39706603
9MP0010352_gastrointestinal_tract_polyps2.34201895
10MP0002877_abnormal_melanocyte_morpholog2.31429266
11MP0005501_abnormal_skin_physiology2.13756727
12MP0003191_abnormal_cellular_cholesterol2.10229336
13MP0004782_abnormal_surfactant_physiolog2.04604443
14MP0005248_abnormal_Harderian_gland2.03921208
15MP0002098_abnormal_vibrissa_morphology2.01956508
16MP0005275_abnormal_skin_tensile2.01721804
17MP0010234_abnormal_vibrissa_follicle2.00020381
18MP0005670_abnormal_white_adipose1.99380740
19MP0001216_abnormal_epidermal_layer1.92279542
20MP0002060_abnormal_skin_morphology1.87897488
21MP0009780_abnormal_chondrocyte_physiolo1.78196050
22MP0000427_abnormal_hair_cycle1.72550480
23MP0009379_abnormal_foot_pigmentation1.72306853
24MP0005083_abnormal_biliary_tract1.71478006
25MP0004484_altered_response_of1.69715229
26MP0002006_tumorigenesis1.68414076
27MP0002138_abnormal_hepatobiliary_system1.67833394
28MP0000569_abnormal_digit_pigmentation1.66627361
29MP0004264_abnormal_extraembryonic_tissu1.64475091
30MP0001879_abnormal_lymphatic_vessel1.63951232
31MP0002166_altered_tumor_susceptibility1.62730090
32MP0003566_abnormal_cell_adhesion1.59473872
33MP0008007_abnormal_cellular_replicative1.58802243
34MP0000490_abnormal_crypts_of1.54547338
35MP0003183_abnormal_peptide_metabolism1.52428664
36MP0001851_eye_inflammation1.51068586
37MP0003693_abnormal_embryo_hatching1.49530495
38MP0000465_gastrointestinal_hemorrhage1.48882156
39MP0000516_abnormal_urinary_system1.48744933
40MP0005367_renal/urinary_system_phenotyp1.48744933
41MP0005666_abnormal_adipose_tissue1.45458020
42MP0002396_abnormal_hematopoietic_system1.45148987
43MP0000613_abnormal_salivary_gland1.44372277
44MP0000647_abnormal_sebaceous_gland1.43122326
45MP0003300_gastrointestinal_ulcer1.37080453
46MP0000566_synostosis1.35090074
47MP0003453_abnormal_keratinocyte_physiol1.34686294
48MP0003786_premature_aging1.32601317
49MP0005451_abnormal_body_composition1.31443230
50MP0001346_abnormal_lacrimal_gland1.30705574
51MP0003011_delayed_dark_adaptation1.29756126
52MP0004883_abnormal_blood_vessel1.27506794
53MP0000377_abnormal_hair_follicle1.27280038
54MP0000383_abnormal_hair_follicle1.27047520
55MP0005379_endocrine/exocrine_gland_phen1.26669273
56MP0001765_abnormal_ion_homeostasis1.25522582
57MP0000627_abnormal_mammary_gland1.21297695
58MP0005375_adipose_tissue_phenotype1.20927804
59MP0005409_darkened_coat_color1.19738973
60MP0004185_abnormal_adipocyte_glucose1.17659044
61MP0004947_skin_inflammation1.17591008
62MP0000579_abnormal_nail_morphology1.17271149
63MP0001191_abnormal_skin_condition1.17027845
64MP0010155_abnormal_intestine_physiology1.16230466
65MP0010678_abnormal_skin_adnexa1.15767561
66MP0008004_abnormal_stomach_pH1.11416097
67MP0005464_abnormal_platelet_physiology1.10272570
68MP0010771_integument_phenotype1.08348545
69MP0003186_abnormal_redox_activity1.07803350
70MP0004130_abnormal_muscle_cell1.05279346
71MP0005408_hypopigmentation1.05040995
72MP0001835_abnormal_antigen_presentation1.02465796
73MP0003866_abnormal_defecation1.01639030
74MP0005076_abnormal_cell_differentiation1.01369863
75MP0001666_abnormal_nutrient_absorption0.98596461
76MP0001986_abnormal_taste_sensitivity0.98251937
77MP0002876_abnormal_thyroid_physiology0.97926857
78MP0010094_abnormal_chromosome_stability0.94115362
79MP0003045_fibrosis0.93410408
80MP0002277_abnormal_respiratory_mucosa0.93369360
81MP0003724_increased_susceptibility_to0.92179864
82MP0003828_pulmonary_edema0.92124670
83MP0010386_abnormal_urinary_bladder0.91757252
84MP0004233_abnormal_muscle_weight0.90097072
85MP0004808_abnormal_hematopoietic_stem0.90027777
86MP0002332_abnormal_exercise_endurance0.89523255
87MP0003890_abnormal_embryonic-extraembry0.89275166
88MP0004381_abnormal_hair_follicle0.87246361
89MP0002909_abnormal_adrenal_gland0.87241595
90MP0001270_distended_abdomen0.86656459
91MP0000015_abnormal_ear_pigmentation0.86132793
92MP0001881_abnormal_mammary_gland0.85495225
93MP0008995_early_reproductive_senescence0.84871591
94MP0009785_altered_susceptibility_to0.84255741
95MP0010030_abnormal_orbit_morphology0.83832190
96MP0002638_abnormal_pupillary_reflex0.83271972
97MP0009697_abnormal_copulation0.82678111
98MP0001800_abnormal_humoral_immune0.82497176
99MP0001186_pigmentation_phenotype0.81420333
100MP0002148_abnormal_hypersensitivity_rea0.81035189
101MP0000858_altered_metastatic_potential0.80802273
102MP0003436_decreased_susceptibility_to0.79851294
103MP0003221_abnormal_cardiomyocyte_apopto0.79074312
104MP0005164_abnormal_response_to0.78526300
105MP0009115_abnormal_fat_cell0.78217005
106MP0008260_abnormal_autophagy0.77763702
107MP0004957_abnormal_blastocyst_morpholog0.75657759
108MP0002102_abnormal_ear_morphology0.74944681
109MP0002998_abnormal_bone_remodeling0.74143315
110MP0000343_altered_response_to0.73608515
111MP0009931_abnormal_skin_appearance0.73590992
112MP0004019_abnormal_vitamin_homeostasis0.73470095
113MP0001664_abnormal_digestion0.73345769
114MP0002693_abnormal_pancreas_physiology0.73060261
115MP0000367_abnormal_coat/_hair0.72627935
116MP0009384_cardiac_valve_regurgitation0.72474152
117MP0003252_abnormal_bile_duct0.71485679
118MP0009764_decreased_sensitivity_to0.71130942
119MP0004084_abnormal_cardiac_muscle0.70777110
120MP0005387_immune_system_phenotype0.70332171
121MP0001790_abnormal_immune_system0.70332171
122MP0003638_abnormal_response/metabolism_0.69842260
123MP0003763_abnormal_thymus_physiology0.69543438
124MP0000762_abnormal_tongue_morphology0.69401570
125MP0005220_abnormal_exocrine_pancreas0.68898622
126MP0004036_abnormal_muscle_relaxation0.68740203
127MP0001919_abnormal_reproductive_system0.68165365
128MP0000003_abnormal_adipose_tissue0.68020727
129MP0005334_abnormal_fat_pad0.67593413
130MP0001873_stomach_inflammation0.67506984
131MP0005310_abnormal_salivary_gland0.66389782
132MP0000371_diluted_coat_color0.65398165
133MP0002132_abnormal_respiratory_system0.64906037
134MP0005389_reproductive_system_phenotype0.64836275
135MP0002971_abnormal_brown_adipose0.63828804
136MP0005166_decreased_susceptibility_to0.63167495
137MP0004215_abnormal_myocardial_fiber0.62999421
138MP0002697_abnormal_eye_size0.62997931
139MP0003077_abnormal_cell_cycle0.62664174
140MP0006072_abnormal_retinal_apoptosis0.62083936
141MP0005025_abnormal_response_to0.60847921
142MP0001727_abnormal_embryo_implantation0.59981320
143MP0005636_abnormal_mineral_homeostasis0.59624762
144MP0002419_abnormal_innate_immunity0.58926202
145MP0001188_hyperpigmentation0.58841993
146MP0002723_abnormal_immune_serum0.58375904
147MP0002269_muscular_atrophy0.56508111
148MP0002452_abnormal_antigen_presenting0.56086391

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.43665284
2Curly hair (HP:0002212)4.19298519
3Aplasia/Hypoplasia involving the sinuses (HP:0009120)4.06716918
4Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.80778649
5Menorrhagia (HP:0000132)3.80275455
6Aplasia cutis congenita (HP:0001057)3.53392527
7Congenital, generalized hypertrichosis (HP:0004540)3.53331318
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47611520
9Chromsome breakage (HP:0040012)3.45153481
10Lip pit (HP:0100267)3.39078831
11Abnormality of the frontal sinuses (HP:0002687)3.33024993
12Reticulocytopenia (HP:0001896)3.32937288
13Onycholysis (HP:0001806)3.31194069
1411 pairs of ribs (HP:0000878)3.30808803
15Woolly hair (HP:0002224)3.24971747
16Median cleft lip (HP:0000161)3.17300389
17Right ventricular cardiomyopathy (HP:0011663)3.08592282
18Pili torti (HP:0003777)3.00957760
19Conjunctival hamartoma (HP:0100780)2.98409650
20Hyporeflexia of lower limbs (HP:0002600)2.97884379
21Thyroid carcinoma (HP:0002890)2.97148866
22Eczematoid dermatitis (HP:0000976)2.96525715
23Prostate neoplasm (HP:0100787)2.94581394
24Increased IgE level (HP:0003212)2.93104039
25Abnormality of the left ventricular outflow tract (HP:0011103)2.93039229
26Subaortic stenosis (HP:0001682)2.93039229
27Abnormality of the columella (HP:0009929)2.90517249
28Duplicated collecting system (HP:0000081)2.88211652
29Ventricular fibrillation (HP:0001663)2.84713510
30Nemaline bodies (HP:0003798)2.81553690
31Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.76772382
32Abnormality of the renal collecting system (HP:0004742)2.74932121
33Muscle fiber inclusion bodies (HP:0100299)2.70060688
34Prolonged bleeding time (HP:0003010)2.69166787
35Hypotrichosis (HP:0001006)2.64025663
36Subacute progressive viral hepatitis (HP:0006572)2.63214127
37High anterior hairline (HP:0009890)2.59026066
38Distal lower limb muscle weakness (HP:0009053)2.58294490
39Ectropion (HP:0000656)2.57641371
40Upper limb muscle weakness (HP:0003484)2.57608684
41Ventricular tachycardia (HP:0004756)2.57170995
42Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.56296261
43Ureteral duplication (HP:0000073)2.52518233
44Natal tooth (HP:0000695)2.47780246
45Hyperkalemia (HP:0002153)2.46875460
46Bundle branch block (HP:0011710)2.44939984
47Flat acetabular roof (HP:0003180)2.42012307
48Abnormality of the common coagulation pathway (HP:0010990)2.40282540
49Acanthosis nigricans (HP:0000956)2.40099599
50Congenital ichthyosiform erythroderma (HP:0007431)2.37924582
51Stomatitis (HP:0010280)2.37759116
52Hyperactive renin-angiotensin system (HP:0000841)2.32889721
53Abnormality of DNA repair (HP:0003254)2.32275890
54Abnormality of the nasal septum (HP:0000419)2.31680638
55Insulin-resistant diabetes mellitus (HP:0000831)2.31238995
56Plantar hyperkeratosis (HP:0007556)2.29702759
57Neoplasm of the tracheobronchial system (HP:0100552)2.27078651
58Termporal pattern (HP:0011008)2.25192205
59Insidious onset (HP:0003587)2.25192205
60Oligomenorrhea (HP:0000876)2.24474574
61Palmar hyperkeratosis (HP:0010765)2.24236594
62Optic neuritis (HP:0100653)2.23531920
63Retrobulbar optic neuritis (HP:0100654)2.23531920
64Alveolar cell carcinoma (HP:0006519)2.22048794
65Broad nasal tip (HP:0000455)2.21805951
66Exercise-induced myalgia (HP:0003738)2.21335051
67Acute myeloid leukemia (HP:0004808)2.18887986
68Alopecia of scalp (HP:0002293)2.15987351
69Abnormal hair laboratory examination (HP:0003328)2.15063913
70Sparse scalp hair (HP:0002209)2.12955472
71Palmoplantar hyperkeratosis (HP:0000972)2.12620727
72Abnormal platelet volume (HP:0011876)2.11544913
73Deep philtrum (HP:0002002)2.11134405
74Autoamputation (HP:0001218)2.09664954
75Increased mean platelet volume (HP:0011877)2.08050794
76Orchitis (HP:0100796)2.07939606
77Entropion (HP:0000621)2.07316114
78Gastrointestinal infarctions (HP:0005244)2.06849214
79Abnormal hemoglobin (HP:0011902)2.06327515
80Sparse lateral eyebrow (HP:0005338)2.05673357
81Milia (HP:0001056)2.05178411
82Autoimmune hemolytic anemia (HP:0001890)2.04787030
83Gingival bleeding (HP:0000225)2.04214909
84Hamartoma of the eye (HP:0010568)2.03585927
85Infertility (HP:0000789)2.02208803
86Corneal erosion (HP:0200020)1.99764851
87Erythema (HP:0010783)1.98154972
88Abnormality of the distal phalanges of the toes (HP:0010182)1.96778165
89Abnormality of the axillary hair (HP:0100134)1.96306441
90Abnormality of secondary sexual hair (HP:0009888)1.96306441
91Epistaxis (HP:0000421)1.95811651
92Septate vagina (HP:0001153)1.95593979
93Dynein arm defect of respiratory motile cilia (HP:0012255)1.95015640
94Absent/shortened dynein arms (HP:0200106)1.95015640
95Keratoconjunctivitis (HP:0001096)1.94554145
96Amaurosis fugax (HP:0100576)1.94488588
97Missing ribs (HP:0000921)1.93185928
98Ventricular arrhythmia (HP:0004308)1.89890414
99Cone-rod dystrophy (HP:0000548)1.89513992
100Hypoplastic labia majora (HP:0000059)1.87671794
101Colon cancer (HP:0003003)1.87489732
102Erythroderma (HP:0001019)1.86490673
103Testicular neoplasm (HP:0010788)1.86027037
104Selective tooth agenesis (HP:0001592)1.85671746
105Palmoplantar keratoderma (HP:0000982)1.85388090
106Keratoconjunctivitis sicca (HP:0001097)1.85360131
107Gangrene (HP:0100758)1.84184649
108Volvulus (HP:0002580)1.83295527
109Biliary tract neoplasm (HP:0100574)1.82776800
110Abnormality of nail color (HP:0100643)1.81537772
111Acanthocytosis (HP:0001927)1.81192806
112Myositis (HP:0100614)1.81158631
113Recurrent cutaneous fungal infections (HP:0011370)1.81096800
114Chronic mucocutaneous candidiasis (HP:0002728)1.81096800
115Cystic hygroma (HP:0000476)1.81050819
116Abnormality of the dental root (HP:0006486)1.80238906
117Taurodontia (HP:0000679)1.80238906
118Abnormality of permanent molar morphology (HP:0011071)1.80238906
119Fair hair (HP:0002286)1.79789649
120Abnormality of the gastric mucosa (HP:0004295)1.79337205
121Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79279991
122Chronic bronchitis (HP:0004469)1.78899878
123Abnormal biliary tract morphology (HP:0012440)1.77923912
124Myocardial infarction (HP:0001658)1.77210468
125Stomach cancer (HP:0012126)1.77023985
126Anhidrosis (HP:0000970)1.76630144
127Abnormality of the salivary glands (HP:0010286)1.76424216
128Coarse hair (HP:0002208)1.75916004
129Mediastinal lymphadenopathy (HP:0100721)1.75432289
130Breast carcinoma (HP:0003002)1.75141572
131Pruritus (HP:0000989)1.74856661
132Blepharitis (HP:0000498)1.74836078
133Arterial thrombosis (HP:0004420)1.74779729
134Thick nail (HP:0001805)1.74475580
135Abnormality of the labia majora (HP:0012881)1.73820816
136Short 1st metacarpal (HP:0010034)1.73621391
137Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.73621391
138Abnormality of the fingertips (HP:0001211)1.73546062
139Germ cell neoplasia (HP:0100728)1.73008080
140Interstitial pulmonary disease (HP:0006530)1.72922483
141Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72583862
142Abnormality of small intestinal villus morphology (HP:0011472)1.72412433
143Villous atrophy (HP:0011473)1.72412433
144Pigmentary retinal degeneration (HP:0001146)1.72085230
145Pallor (HP:0000980)1.71423416
146Central scotoma (HP:0000603)1.71326707
147Advanced eruption of teeth (HP:0006288)1.70923200
148Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70662480
149Sparse eyelashes (HP:0000653)1.70363944
150Hyponatremia (HP:0002902)1.69930305
151Poikiloderma (HP:0001029)1.69925473
152Abnormality of T cell physiology (HP:0011840)1.69816482
153Concave nail (HP:0001598)1.68335784
154Stenosis of the external auditory canal (HP:0000402)1.67526766
155Abnormality of the hepatic vasculature (HP:0006707)1.67110603
156Micronodular cirrhosis (HP:0001413)1.66524555
157Hyperglycemia (HP:0003074)1.65305828
158Recurrent bacterial skin infections (HP:0005406)1.65106772
159Recurrent fungal infections (HP:0002841)1.64953555
160Recurrent abscess formation (HP:0002722)1.63190659
161Anorexia (HP:0002039)1.62929364
162Keratitis (HP:0000491)1.62847429
163Submucous cleft hard palate (HP:0000176)1.62556629
164Ectopic kidney (HP:0000086)1.62085124
165Portal hypertension (HP:0001409)1.61049261
166Abnormal blistering of the skin (HP:0008066)1.60734747
167Hypohidrosis (HP:0000966)1.60339270
168Abnormal delayed hypersensitivity skin test (HP:0002963)1.58119504
169Absent thumb (HP:0009777)1.57838473
170Hypoplasia of dental enamel (HP:0006297)1.57481426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.53312370
2MST44.43953412
3EPHA23.07873601
4BCKDK3.07702883
5LATS12.52681742
6STK242.39729040
7STK392.31073684
8AKT32.29273096
9BMPR22.20564680
10FRK2.17473250
11BRD42.10280175
12SCYL22.09587267
13PIM22.08166544
14MAP3K32.06743052
15TIE11.99825933
16NUAK11.98428726
17MAP2K31.94407639
18NEK91.83602951
19CAMK1D1.80137318
20ZAK1.79521403
21EPHA31.71363523
22JAK31.69796201
23MAP3K121.66706407
24IRAK41.63780457
25RPS6KB21.63124101
26TAOK31.56972710
27TAOK21.56463110
28PIK3CG1.51892199
29IRAK11.51711422
30FGFR41.50161653
31MAP3K21.47963840
32YES11.44561808
33TRPM71.40167211
34CDK61.39717476
35RIPK41.38192838
36RIPK11.36758632
37GRK61.36588274
38EIF2AK11.32606748
39FGFR31.31278712
40EIF2AK21.31255017
41TEC1.31224744
42INSRR1.27351149
43CSK1.26751943
44STK38L1.24818355
45STK101.24754467
46PIM11.21109159
47GRK11.20730238
48IKBKE1.16873017
49FER1.14493245
50EPHB11.14150977
51MKNK21.10925434
52CAMKK21.09407097
53SIK31.09339117
54MET1.07905205
55SRPK11.01988878
56MAP3K141.01740468
57MAPKAPK31.01095696
58EPHB21.00262420
59NLK1.00113684
60RPS6KA40.99797051
61SGK30.95858874
62MAP3K60.94195560
63WNK10.93936942
64CHUK0.92990644
65MAP3K10.92666904
66ERBB30.89893435
67MKNK10.88865645
68HIPK20.88715584
69EEF2K0.88467462
70ATR0.87800524
71WNK40.86564826
72OXSR10.85095131
73FGFR10.84266939
74TGFBR20.83628757
75DYRK30.83354925
76LRRK20.82540025
77RPS6KA50.80451439
78BLK0.80437305
79AURKB0.80126098
80STK380.79236566
81IRAK20.78767015
82TTK0.77610943
83TYK20.75349467
84IKBKB0.75290056
85DMPK0.74594156
86PRPF4B0.73290411
87STK30.69692043
88SIK10.69418410
89MAPK150.69097742
90HCK0.68366883
91CDK120.67962328
92RPS6KB10.66740527
93FLT30.64216860
94TTN0.63479542
95TGFBR10.62518564
96PBK0.62460929
97JAK10.61383308
98NEK60.61000624
99MATK0.60475490
100MST1R0.58948220
101BTK0.58602020
102PIK3CA0.58420733
103KSR20.57884997
104OBSCN0.56859161
105PTK60.55659718
106PASK0.54146474
107CAMK1G0.52520342
108FGFR20.51854202
109MAPK120.50429566
110CDK90.50165346
111JAK20.49996955
112RPS6KA60.49661626
113RPS6KC10.49093644
114RPS6KL10.49093644
115MAP3K50.48213938
116MAPK70.47887375
117TNK20.47284544
118TSSK60.46880249
119FGR0.46098351
120DYRK1B0.45881534
121CSF1R0.45502868
122ACVR1B0.45148469
123TBK10.44372048
124PDK10.44104906
125IGF1R0.43345751
126MUSK0.42404163
127PLK40.40742731
128EIF2AK30.40483687
129ATM0.40151692
130ZAP700.39401847
131AKT10.38880927
132PDPK10.38869785
133CDK70.38480103
134ABL10.38175981
135BRSK20.38135980
136MAP2K40.37406654
137RET0.37355122
138PRKAA20.36760673
139MAP2K60.36432135
140NME20.36323929
141PDGFRB0.34779370
142PRKCI0.34704441
143PLK10.33829266
144KIT0.33118209
145SGK20.33032126
146PDGFRA0.32849307

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.27508743
2Circadian rhythm_Homo sapiens_hsa047102.21551845
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.12708185
4Inositol phosphate metabolism_Homo sapiens_hsa005621.91934033
5T cell receptor signaling pathway_Homo sapiens_hsa046601.84795787
6Phosphatidylinositol signaling system_Homo sapiens_hsa040701.78881262
7Leishmaniasis_Homo sapiens_hsa051401.77012753
8Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.75656107
9Ribosome_Homo sapiens_hsa030101.73263514
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71940360
11Fanconi anemia pathway_Homo sapiens_hsa034601.70661898
12Adherens junction_Homo sapiens_hsa045201.69865640
13Endometrial cancer_Homo sapiens_hsa052131.69813903
14Renal cell carcinoma_Homo sapiens_hsa052111.68983410
15Homologous recombination_Homo sapiens_hsa034401.67166156
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.66767631
17TNF signaling pathway_Homo sapiens_hsa046681.65701510
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.63784544
19Mismatch repair_Homo sapiens_hsa034301.61974585
20Legionellosis_Homo sapiens_hsa051341.56944609
21Non-small cell lung cancer_Homo sapiens_hsa052231.54555449
22ABC transporters_Homo sapiens_hsa020101.54106646
23Transcriptional misregulation in cancer_Homo sapiens_hsa052021.54046357
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.52752121
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49320268
26B cell receptor signaling pathway_Homo sapiens_hsa046621.48220607
27Pancreatic cancer_Homo sapiens_hsa052121.47486182
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.44468158
29Hepatitis C_Homo sapiens_hsa051601.41880266
30FoxO signaling pathway_Homo sapiens_hsa040681.41607516
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41214124
32Arachidonic acid metabolism_Homo sapiens_hsa005901.41172060
33Dorso-ventral axis formation_Homo sapiens_hsa043201.40466485
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.37039318
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.34322494
36Protein export_Homo sapiens_hsa030601.32681364
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32358283
38Base excision repair_Homo sapiens_hsa034101.31907703
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28836649
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26900969
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26250311
42Regulation of autophagy_Homo sapiens_hsa041401.26180911
43Toxoplasmosis_Homo sapiens_hsa051451.25421796
44p53 signaling pathway_Homo sapiens_hsa041151.23817554
45Fatty acid biosynthesis_Homo sapiens_hsa000611.23521256
46VEGF signaling pathway_Homo sapiens_hsa043701.23393871
47Measles_Homo sapiens_hsa051621.20664447
48Caffeine metabolism_Homo sapiens_hsa002321.20185194
49Sphingolipid signaling pathway_Homo sapiens_hsa040711.18107163
50Small cell lung cancer_Homo sapiens_hsa052221.16765921
51Herpes simplex infection_Homo sapiens_hsa051681.16487014
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16383772
53Choline metabolism in cancer_Homo sapiens_hsa052311.15812119
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.14079555
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.13410682
56Prostate cancer_Homo sapiens_hsa052151.10655302
57Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07628457
58Renin secretion_Homo sapiens_hsa049241.07337633
59ErbB signaling pathway_Homo sapiens_hsa040121.05454955
60Insulin signaling pathway_Homo sapiens_hsa049101.05123941
61GnRH signaling pathway_Homo sapiens_hsa049121.04220517
62mTOR signaling pathway_Homo sapiens_hsa041501.03654476
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02174411
64Pertussis_Homo sapiens_hsa051331.01056914
65Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00965787
66Tight junction_Homo sapiens_hsa045301.00783593
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99465503
68Pancreatic secretion_Homo sapiens_hsa049720.96308078
69MicroRNAs in cancer_Homo sapiens_hsa052060.95730342
70TGF-beta signaling pathway_Homo sapiens_hsa043500.95288225
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.93638753
72Endocytosis_Homo sapiens_hsa041440.92875024
73Influenza A_Homo sapiens_hsa051640.92488225
74Hematopoietic cell lineage_Homo sapiens_hsa046400.92365915
75Chemokine signaling pathway_Homo sapiens_hsa040620.91951576
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91309232
77Hippo signaling pathway_Homo sapiens_hsa043900.90284781
78Histidine metabolism_Homo sapiens_hsa003400.89974464
79Vitamin digestion and absorption_Homo sapiens_hsa049770.89230998
80Notch signaling pathway_Homo sapiens_hsa043300.88386372
81Nucleotide excision repair_Homo sapiens_hsa034200.87318156
82Cell cycle_Homo sapiens_hsa041100.86551407
83Nitrogen metabolism_Homo sapiens_hsa009100.86078528
84Glucagon signaling pathway_Homo sapiens_hsa049220.85517510
85Sphingolipid metabolism_Homo sapiens_hsa006000.85496137
86Acute myeloid leukemia_Homo sapiens_hsa052210.85466517
87Proteoglycans in cancer_Homo sapiens_hsa052050.85243206
88Tuberculosis_Homo sapiens_hsa051520.84792884
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84688890
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84586663
91AMPK signaling pathway_Homo sapiens_hsa041520.84058447
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83832336
93Apoptosis_Homo sapiens_hsa042100.83586818
94Basal cell carcinoma_Homo sapiens_hsa052170.82761546
95beta-Alanine metabolism_Homo sapiens_hsa004100.82432827
96Starch and sucrose metabolism_Homo sapiens_hsa005000.82126959
97One carbon pool by folate_Homo sapiens_hsa006700.81948073
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80973394
99Viral carcinogenesis_Homo sapiens_hsa052030.80321888
100Prolactin signaling pathway_Homo sapiens_hsa049170.79305269
101Pathways in cancer_Homo sapiens_hsa052000.79255160
102ECM-receptor interaction_Homo sapiens_hsa045120.78000654
103Graft-versus-host disease_Homo sapiens_hsa053320.77980980
104Phenylalanine metabolism_Homo sapiens_hsa003600.77951853
105Malaria_Homo sapiens_hsa051440.76170104
106Autoimmune thyroid disease_Homo sapiens_hsa053200.75876965
107Insulin resistance_Homo sapiens_hsa049310.74058723
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73759613
109HTLV-I infection_Homo sapiens_hsa051660.73525829
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73187982
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.72610043
112Long-term depression_Homo sapiens_hsa047300.72377556
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71984033
114DNA replication_Homo sapiens_hsa030300.71671889
115Chronic myeloid leukemia_Homo sapiens_hsa052200.70189206
116Focal adhesion_Homo sapiens_hsa045100.70014347
117Thyroid cancer_Homo sapiens_hsa052160.69545120
118Staphylococcus aureus infection_Homo sapiens_hsa051500.68259179
119Colorectal cancer_Homo sapiens_hsa052100.66975205
120Selenocompound metabolism_Homo sapiens_hsa004500.66952702
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66903140
122Hepatitis B_Homo sapiens_hsa051610.66498899
123PPAR signaling pathway_Homo sapiens_hsa033200.65376313
124Linoleic acid metabolism_Homo sapiens_hsa005910.65302258
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.65175046
126Propanoate metabolism_Homo sapiens_hsa006400.64750608
127Non-homologous end-joining_Homo sapiens_hsa034500.63955855
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63334798
129Antigen processing and presentation_Homo sapiens_hsa046120.63138834
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63011152
131Bladder cancer_Homo sapiens_hsa052190.61881358
132Osteoclast differentiation_Homo sapiens_hsa043800.61735083
133Estrogen signaling pathway_Homo sapiens_hsa049150.61565264
134Retinol metabolism_Homo sapiens_hsa008300.61032632
135Epstein-Barr virus infection_Homo sapiens_hsa051690.60224686
136Melanoma_Homo sapiens_hsa052180.59808041
137Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58360118
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57601105
139N-Glycan biosynthesis_Homo sapiens_hsa005100.56618602
140Allograft rejection_Homo sapiens_hsa053300.56305548
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55918247
142Rheumatoid arthritis_Homo sapiens_hsa053230.55660554
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.55427792
144Renin-angiotensin system_Homo sapiens_hsa046140.55377554
145Platelet activation_Homo sapiens_hsa046110.54047526
146Phototransduction_Homo sapiens_hsa047440.53631510
147Oxytocin signaling pathway_Homo sapiens_hsa049210.53257338
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52814136
149Olfactory transduction_Homo sapiens_hsa047400.52346741
150Amoebiasis_Homo sapiens_hsa051460.51669671
151Shigellosis_Homo sapiens_hsa051310.51660314
152Serotonergic synapse_Homo sapiens_hsa047260.50957639
153Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50515367
154Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50292192
155Glioma_Homo sapiens_hsa052140.48459138
156Phospholipase D signaling pathway_Homo sapiens_hsa040720.47930004
157Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45591994

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