MPPE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.49679246
2negative regulation of cell killing (GO:0031342)5.98570743
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.98570743
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.94614969
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.94614969
6negative T cell selection (GO:0043383)5.44180881
7antigen processing and presentation of endogenous antigen (GO:0019883)5.35379836
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.31325541
9regulation of B cell receptor signaling pathway (GO:0050855)5.31291662
10negative thymic T cell selection (GO:0045060)5.30928770
11regulation of isotype switching to IgG isotypes (GO:0048302)5.17167921
12positive thymic T cell selection (GO:0045059)5.06953973
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.98843650
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.98843650
15modulation by symbiont of host immune response (GO:0052553)4.98843650
16positive regulation by symbiont of host defense response (GO:0052509)4.98843650
17modulation by symbiont of host defense response (GO:0052031)4.98843650
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.98843650
19regulation of gamma-delta T cell differentiation (GO:0045586)4.97230637
20regulation of gamma-delta T cell activation (GO:0046643)4.71025244
21leukocyte aggregation (GO:0070486)4.38298908
22interferon-gamma production (GO:0032609)4.36442167
23positive T cell selection (GO:0043368)4.33743403
24thymic T cell selection (GO:0045061)4.33232749
25response to interleukin-15 (GO:0070672)4.32794279
26T cell migration (GO:0072678)4.32748553
27microglial cell activation (GO:0001774)4.13177106
28regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.12251521
29cellular response to interleukin-15 (GO:0071350)4.07190920
30detection of other organism (GO:0098543)4.05459536
31macrophage activation involved in immune response (GO:0002281)4.02086892
32positive regulation of isotype switching (GO:0045830)3.95108085
33T cell selection (GO:0045058)3.94977186
34detection of molecule of bacterial origin (GO:0032490)3.91433743
35neutrophil activation (GO:0042119)3.89003935
36cellular extravasation (GO:0045123)3.85313928
37detection of bacterium (GO:0016045)3.81531401
38regulation of B cell differentiation (GO:0045577)3.79757785
39regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.74231056
40Arp2/3 complex-mediated actin nucleation (GO:0034314)3.72608860
41detection of external biotic stimulus (GO:0098581)3.69462004
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.63809640
43positive regulation of DNA recombination (GO:0045911)3.63165357
44response to peptidoglycan (GO:0032494)3.62113233
45respiratory burst (GO:0045730)3.58163623
46regulation of alpha-beta T cell proliferation (GO:0046640)3.57021290
47activated T cell proliferation (GO:0050798)3.55246505
48T cell receptor signaling pathway (GO:0050852)3.49771932
49regulation of response to interferon-gamma (GO:0060330)3.49178896
50negative regulation of interleukin-12 production (GO:0032695)3.48635957
51regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.45527833
52T cell costimulation (GO:0031295)3.45075649
53regulation of T cell receptor signaling pathway (GO:0050856)3.44980775
54B cell receptor signaling pathway (GO:0050853)3.44787865
55response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.43632233
56response to host immune response (GO:0052572)3.43632233
57neutrophil mediated immunity (GO:0002446)3.43118809
58lymphocyte costimulation (GO:0031294)3.42746113
59positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.42017244
60immunoglobulin mediated immune response (GO:0016064)3.39544228
61negative regulation of phagocytosis (GO:0050765)3.39122969
62antigen receptor-mediated signaling pathway (GO:0050851)3.37340588
63positive regulation of alpha-beta T cell proliferation (GO:0046641)3.35694640
64megakaryocyte development (GO:0035855)3.35576062
65negative regulation of leukocyte mediated immunity (GO:0002704)3.35044711
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.34900625
67positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.34845103
68regulation of isotype switching (GO:0045191)3.32955747
69granulocyte activation (GO:0036230)3.32251668
70positive regulation of B cell differentiation (GO:0045579)3.30684301
71macrophage activation (GO:0042116)3.30366972
72positive regulation of B cell mediated immunity (GO:0002714)3.26351812
73positive regulation of immunoglobulin mediated immune response (GO:0002891)3.26351812
74myeloid cell activation involved in immune response (GO:0002275)3.19645514
75positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.18121606
76detection of biotic stimulus (GO:0009595)3.17554554
77mast cell activation (GO:0045576)3.15379129
78negative regulation of interleukin-1 production (GO:0032692)3.13625186
79antigen processing and presentation via MHC class Ib (GO:0002475)3.13381091
80positive regulation of humoral immune response (GO:0002922)3.11884571
81negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.10321390
82negative regulation of T-helper cell differentiation (GO:0045623)3.10321390
83ribosomal small subunit assembly (GO:0000028)3.10002640
84leukocyte migration involved in inflammatory response (GO:0002523)3.07217774
85regulation of B cell mediated immunity (GO:0002712)3.07208183
86positive regulation of natural killer cell mediated immunity (GO:0002717)3.05741008
87positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.05741008
88regulation of immunoglobulin mediated immune response (GO:0002889)3.05406660
89sequestering of actin monomers (GO:0042989)3.04977576
90regulation of regulatory T cell differentiation (GO:0045589)3.04974909
91negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.04277124
92regulation of mast cell activation (GO:0033003)3.03691853
93leukocyte degranulation (GO:0043299)3.02059500
94dendritic cell migration (GO:0036336)3.01995934
95negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.99914731
96regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.99450302
97regulation of natural killer cell mediated immunity (GO:0002715)2.99450302
98negative regulation of interleukin-6 production (GO:0032715)2.98131806
99lymph node development (GO:0048535)2.95085294
100regulation of type I interferon-mediated signaling pathway (GO:0060338)2.93359403
101negative regulation of interleukin-1 beta production (GO:0032691)2.92627034
102DNA deamination (GO:0045006)2.92343382
103defense response to protozoan (GO:0042832)2.92282340
104regulation of interleukin-6 biosynthetic process (GO:0045408)2.92050782
105regulation of T cell mediated cytotoxicity (GO:0001914)2.90242309
106positive regulation of mast cell activation (GO:0033005)2.89093754
107negative regulation of immunoglobulin mediated immune response (GO:0002890)2.89061662
108negative regulation of B cell mediated immunity (GO:0002713)2.89061662
109positive regulation of granulocyte differentiation (GO:0030854)2.88717349
110response to host (GO:0075136)2.87170233
111response to host defenses (GO:0052200)2.87170233
112response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.87170233
113regulation of leukocyte mediated cytotoxicity (GO:0001910)2.86884446
114T cell homeostasis (GO:0043029)2.86031806
115myeloid leukocyte mediated immunity (GO:0002444)2.85093549
116response to type I interferon (GO:0034340)2.84968134
117production of molecular mediator involved in inflammatory response (GO:0002532)2.84087646
118regulation of tolerance induction (GO:0002643)2.82054716
119cellular response to type I interferon (GO:0071357)2.82030225
120type I interferon signaling pathway (GO:0060337)2.82030225
121NIK/NF-kappaB signaling (GO:0038061)2.81156818
122regulation of interferon-beta biosynthetic process (GO:0045357)2.80452355
123negative regulation of alpha-beta T cell activation (GO:0046636)2.79060283
124leukocyte cell-cell adhesion (GO:0007159)2.78993637
125positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.78182397
126negative regulation of adaptive immune response (GO:0002820)2.76548993
127tolerance induction (GO:0002507)2.76498845
128pyrimidine ribonucleoside catabolic process (GO:0046133)2.74603734
129cytidine metabolic process (GO:0046087)2.74453408
130cytidine catabolic process (GO:0006216)2.74453408
131cytidine deamination (GO:0009972)2.74453408
132interferon-gamma-mediated signaling pathway (GO:0060333)2.73135777
133negative regulation of innate immune response (GO:0045824)2.72784422
134positive regulation of antigen processing and presentation (GO:0002579)2.71671002
135positive regulation of immunoglobulin production (GO:0002639)2.71225779
136regulation of memory T cell differentiation (GO:0043380)2.71149398
137positive regulation of response to tumor cell (GO:0002836)2.70726069
138positive regulation of immune response to tumor cell (GO:0002839)2.70726069
139regulation of immune response to tumor cell (GO:0002837)2.70726069
140regulation of response to tumor cell (GO:0002834)2.70726069
141regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.70413591
142natural killer cell activation (GO:0030101)2.68971454
143negative regulation of T cell receptor signaling pathway (GO:0050860)2.68960784
144pinocytosis (GO:0006907)2.67528569
145neutrophil activation involved in immune response (GO:0002283)2.66137824
146negative regulation of T cell mediated immunity (GO:0002710)2.63513227
147negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.63509339
148angiogenesis involved in wound healing (GO:0060055)2.61964691
149cellular response to exogenous dsRNA (GO:0071360)2.61727524
150lymphocyte migration (GO:0072676)2.61453487
151positive regulation of lamellipodium assembly (GO:0010592)2.61075461
152positive regulation of interleukin-2 production (GO:0032743)2.59240769
153regulation of cell killing (GO:0031341)2.59181326
154negative regulation of lymphocyte mediated immunity (GO:0002707)2.57723255
155myeloid dendritic cell activation (GO:0001773)2.57643892
156positive regulation of T cell mediated cytotoxicity (GO:0001916)2.57202711
157actin nucleation (GO:0045010)2.56565760
158lymphocyte homeostasis (GO:0002260)2.53181766
159mast cell activation involved in immune response (GO:0002279)2.52801144
160mast cell degranulation (GO:0043303)2.52801144
161regulation of RIG-I signaling pathway (GO:0039535)2.52676731
162regulation of T cell tolerance induction (GO:0002664)2.52059230
163response to protozoan (GO:0001562)2.51982083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.15078981
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.80284303
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.77259042
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.69857074
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.07141886
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.93103814
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.88438837
8* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.77922603
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71906251
10GATA1_22025678_ChIP-Seq_K562_Human2.71842307
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.71770643
12E2F7_22180533_ChIP-Seq_HELA_Human2.70874180
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.69098123
14* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.67193519
15MYC_22102868_ChIP-Seq_BL_Human2.58946334
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.46670735
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.45648837
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.43271844
19SCL_19346495_ChIP-Seq_HPC-7_Human2.41371600
20MYB_26560356_Chip-Seq_TH2_Human2.39436770
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.29767607
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.28735033
23RUNX_20019798_ChIP-Seq_JUKART_Human2.24807846
24* SPI1_23547873_ChIP-Seq_NB4_Human2.07735547
25MYB_26560356_Chip-Seq_TH1_Human2.06526369
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05526544
27MAF_26560356_Chip-Seq_TH1_Human2.02111548
28NOTCH1_21737748_ChIP-Seq_TLL_Human2.01713170
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.97529507
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.94856850
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.93441873
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90815959
33* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.90273645
34VDR_21846776_ChIP-Seq_THP-1_Human1.88302403
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87378724
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86614291
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86544730
38SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.86194623
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85721150
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84847494
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80600471
42* UTX_26944678_Chip-Seq_JUKART_Human1.77819077
43* RUNX1_22412390_ChIP-Seq_EML_Mouse1.77791178
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77450688
45ZNF274_21170338_ChIP-Seq_K562_Hela1.75852422
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.73047602
47* VDR_23849224_ChIP-Seq_CD4+_Human1.72546731
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69182016
49* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68414211
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.68164374
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63463887
52CIITA_25753668_ChIP-Seq_RAJI_Human1.61511790
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.60075901
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59874327
55* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58188055
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.56834224
57FOXP3_21729870_ChIP-Seq_TREG_Human1.55514286
58VDR_24787735_ChIP-Seq_THP-1_Human1.55437817
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52969273
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48311460
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46559492
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45793163
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45402074
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.44876314
65* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.44385735
66PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44339756
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42258823
68VDR_24763502_ChIP-Seq_THP-1_Human1.41984656
69GATA3_27048872_Chip-Seq_THYMUS_Human1.40727566
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.40372207
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.40369908
72MAF_26560356_Chip-Seq_TH2_Human1.39001626
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.35773220
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34994192
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33382105
76* GATA1_19941827_ChIP-Seq_MEL_Mouse1.32517921
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32330878
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.28779829
79TCF7_22412390_ChIP-Seq_EML_Mouse1.28229792
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25624875
81ER_23166858_ChIP-Seq_MCF-7_Human1.24401002
82SPI1_23127762_ChIP-Seq_K562_Human1.22902820
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22695159
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22103127
85MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20791128
86CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19416656
87GATA3_26560356_Chip-Seq_TH2_Human1.17457239
88PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17381936
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15874375
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14780506
91GABP_19822575_ChIP-Seq_HepG2_Human1.13733748
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12753904
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12265741
94ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11236687
95MYC_18555785_ChIP-Seq_MESCs_Mouse1.11021877
96SMRT_27268052_Chip-Seq_Bcells_Human1.10108539
97PU_27001747_Chip-Seq_BMDM_Mouse1.08807223
98RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08719902
99VDR_22108803_ChIP-Seq_LS180_Human1.08384511
100POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08283677
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.06493246
102TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05795464
103ELK1_19687146_ChIP-ChIP_HELA_Human1.05608614
104* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04601048
105* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03590706
106PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03588842
107XRN2_22483619_ChIP-Seq_HELA_Human1.03480496
108TFEB_21752829_ChIP-Seq_HELA_Human1.02912123
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02733941
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02657553
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02187355
112GATA3_21878914_ChIP-Seq_MCF-7_Human1.01527176
113ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00880892
114EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00491965
115VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00475065
116* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00436701
117GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99324376
118STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98915769
119RXR_22158963_ChIP-Seq_LIVER_Mouse0.98876257
120BCAT_22108803_ChIP-Seq_LS180_Human0.98333374
121SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97951186
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97073032
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96401667
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95727473
125EZH2_27294783_Chip-Seq_NPCs_Mouse0.95479047
126TP53_22573176_ChIP-Seq_HFKS_Human0.94864428
127DCP1A_22483619_ChIP-Seq_HELA_Human0.94762669
128* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94093918
129* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93821637
130NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93779875
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91234015
132CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89861946
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89690136
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.89499619
135FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89396269
136FOXA1_25329375_ChIP-Seq_VCAP_Human0.89396269
137NANOG_20526341_ChIP-Seq_ESCs_Human0.89207956
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88932288
139AR_20517297_ChIP-Seq_VCAP_Human0.88921911
140MYC_19030024_ChIP-ChIP_MESCs_Mouse0.88023827
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87520099
142RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86632627
143FOXA1_21572438_ChIP-Seq_LNCaP_Human0.85308874
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84656242
145* GATA3_26560356_Chip-Seq_TH1_Human0.84614827
146GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84368771
147GBX2_23144817_ChIP-Seq_PC3_Human0.84151661
148CEBPB_22108803_ChIP-Seq_LS180_Human0.83718433
149CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83327023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.83383049
2MP0005671_abnormal_response_to3.80306391
3MP0001835_abnormal_antigen_presentation3.77217247
4MP0000685_abnormal_immune_system3.27117572
5MP0009785_altered_susceptibility_to3.11964966
6MP0001800_abnormal_humoral_immune2.88979131
7MP0002396_abnormal_hematopoietic_system2.67105204
8MP0005387_immune_system_phenotype2.64977496
9MP0001790_abnormal_immune_system2.64977496
10MP0005000_abnormal_immune_tolerance2.61677211
11MP0005025_abnormal_response_to2.52647127
12MP0002420_abnormal_adaptive_immunity2.52492096
13MP0002398_abnormal_bone_marrow2.51967785
14MP0003436_decreased_susceptibility_to2.51583125
15MP0001819_abnormal_immune_cell2.50179903
16MP0002723_abnormal_immune_serum2.50147780
17MP0009333_abnormal_splenocyte_physiolog2.41996343
18MP0002452_abnormal_antigen_presenting2.40351108
19MP0002405_respiratory_system_inflammati2.24912591
20MP0003724_increased_susceptibility_to2.22168364
21MP0000716_abnormal_immune_system2.20028757
22MP0002419_abnormal_innate_immunity2.14394308
23MP0002148_abnormal_hypersensitivity_rea2.13834446
24MP0000689_abnormal_spleen_morphology2.11453733
25MP0005464_abnormal_platelet_physiology2.09242695
26MP0002722_abnormal_immune_system2.06949493
27MP0004147_increased_porphyrin_level1.97707034
28MP0002429_abnormal_blood_cell1.93164868
29MP0006082_CNS_inflammation1.92569426
30MP0002166_altered_tumor_susceptibility1.90712266
31MP0002132_abnormal_respiratory_system1.89806799
32MP0002277_abnormal_respiratory_mucosa1.83897089
33MP0001873_stomach_inflammation1.83391761
34MP0005360_urolithiasis1.82324253
35MP0003656_abnormal_erythrocyte_physiolo1.81708178
36MP0010155_abnormal_intestine_physiology1.81687894
37MP0000703_abnormal_thymus_morphology1.79244145
38MP0001853_heart_inflammation1.78013132
39MP0001845_abnormal_inflammatory_respons1.77406124
40MP0005397_hematopoietic_system_phenotyp1.61770549
41MP0001545_abnormal_hematopoietic_system1.61770549
42MP0003191_abnormal_cellular_cholesterol1.60561940
43MP0003806_abnormal_nucleotide_metabolis1.60294252
44MP0004947_skin_inflammation1.57460403
45MP0005075_abnormal_melanosome_morpholog1.55938043
46MP0003866_abnormal_defecation1.55339348
47MP0003195_calcinosis1.51476223
48MP0008469_abnormal_protein_level1.51204824
49MP0004808_abnormal_hematopoietic_stem1.50857951
50MP0000569_abnormal_digit_pigmentation1.49816345
51MP0009840_abnormal_foam_cell1.47862567
52MP0004381_abnormal_hair_follicle1.42764816
53MP0004883_abnormal_blood_vessel1.42036159
54MP0003172_abnormal_lysosome_physiology1.37703570
55MP0002006_tumorigenesis1.34426685
56MP0000858_altered_metastatic_potential1.31623028
57MP0002876_abnormal_thyroid_physiology1.30981588
58MP0003183_abnormal_peptide_metabolism1.29230290
59MP0000490_abnormal_crypts_of1.26890480
60MP0005365_abnormal_bile_salt1.24522028
61MP0000465_gastrointestinal_hemorrhage1.24104791
62MP0004510_myositis1.17550222
63MP0002138_abnormal_hepatobiliary_system1.16912091
64MP0003252_abnormal_bile_duct1.16257633
65MP0001533_abnormal_skeleton_physiology1.16141901
66MP0002928_abnormal_bile_duct1.14714141
67MP0005310_abnormal_salivary_gland1.14473287
68MP0002933_joint_inflammation1.13911500
69MP0003011_delayed_dark_adaptation1.11372098
70MP0005058_abnormal_lysosome_morphology1.10616101
71MP0005084_abnormal_gallbladder_morpholo1.09276387
72MP0004142_abnormal_muscle_tone1.05357139
73MP0003300_gastrointestinal_ulcer1.05266345
74MP0002019_abnormal_tumor_incidence1.03629951
75MP0000609_abnormal_liver_physiology1.01738859
76MP0003787_abnormal_imprinting1.01390723
77MP0001764_abnormal_homeostasis1.01324585
78MP0002139_abnormal_hepatobiliary_system1.00409089
79MP0003646_muscle_fatigue0.99033649
80MP0003693_abnormal_embryo_hatching0.98859587
81MP0003045_fibrosis0.97694018
82MP0005164_abnormal_response_to0.97308831
83MP0009764_decreased_sensitivity_to0.96980929
84MP0003303_peritoneal_inflammation0.96431398
85MP0002653_abnormal_ependyma_morphology0.91411857
86MP0006054_spinal_hemorrhage0.90509658
87MP0009763_increased_sensitivity_to0.88372148
88MP0001986_abnormal_taste_sensitivity0.88211047
89MP0004484_altered_response_of0.87252123
90MP0003075_altered_response_to0.87045576
91MP0008877_abnormal_DNA_methylation0.86968914
92MP0001851_eye_inflammation0.86716128
93MP0005319_abnormal_enzyme/_coenzyme0.83554200
94MP0001501_abnormal_sleep_pattern0.83311162
95MP0002909_abnormal_adrenal_gland0.82488571
96MP0001663_abnormal_digestive_system0.82487008
97MP0005584_abnormal_enzyme/coenzyme_acti0.82204743
98MP0009765_abnormal_xenobiotic_induced0.81845249
99MP0008872_abnormal_physiological_respon0.81198262
100MP0003828_pulmonary_edema0.80513948
101MP0009643_abnormal_urine_homeostasis0.80127492
102MP0005085_abnormal_gallbladder_physiolo0.78804514
103MP0006036_abnormal_mitochondrial_physio0.78375969
104MP0008057_abnormal_DNA_replication0.76836572
105MP0008007_abnormal_cellular_replicative0.75175541
106MP0000015_abnormal_ear_pigmentation0.75009779
107MP0005451_abnormal_body_composition0.74164796
108MP0000343_altered_response_to0.74002154
109MP0003943_abnormal_hepatobiliary_system0.73168811
110MP0004043_abnormal_pH_regulation0.73099257
111MP0010329_abnormal_lipoprotein_level0.72768553
112MP0000598_abnormal_liver_morphology0.72688919
113MP0004130_abnormal_muscle_cell0.71076710
114MP0005166_decreased_susceptibility_to0.70587794
115MP0003448_altered_tumor_morphology0.70296537
116MP0003878_abnormal_ear_physiology0.68819546
117MP0005377_hearing/vestibular/ear_phenot0.68819546
118MP0005376_homeostasis/metabolism_phenot0.68568500
119MP0002095_abnormal_skin_pigmentation0.68334396
120MP0008875_abnormal_xenobiotic_pharmacok0.67122164
121MP0003077_abnormal_cell_cycle0.66358393
122MP0002136_abnormal_kidney_physiology0.66277633
123MP0009278_abnormal_bone_marrow0.65678781
124MP0003186_abnormal_redox_activity0.65253048
125MP0002332_abnormal_exercise_endurance0.65166010
126MP0001666_abnormal_nutrient_absorption0.64621141
127MP0005023_abnormal_wound_healing0.62731784
128MP0005174_abnormal_tail_pigmentation0.61770637
129MP0008260_abnormal_autophagy0.60241294
130MP0002693_abnormal_pancreas_physiology0.59898778

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.77312019
2Abnormality of T cell number (HP:0011839)4.58959723
3IgM deficiency (HP:0002850)4.51912600
4Panhypogammaglobulinemia (HP:0003139)4.32921864
5Abnormality of T cells (HP:0002843)4.16605394
6Abnormal delayed hypersensitivity skin test (HP:0002963)4.13908755
7Recurrent fungal infections (HP:0002841)3.96642216
8Recurrent bronchitis (HP:0002837)3.94458785
9Recurrent viral infections (HP:0004429)3.89900603
10Chronic mucocutaneous candidiasis (HP:0002728)3.89045877
11Recurrent cutaneous fungal infections (HP:0011370)3.89045877
12Elevated erythrocyte sedimentation rate (HP:0003565)3.87464751
13Severe combined immunodeficiency (HP:0004430)3.87207515
14Eczematoid dermatitis (HP:0000976)3.85672953
15Recurrent abscess formation (HP:0002722)3.69030713
16Agammaglobulinemia (HP:0004432)3.66630421
17Myositis (HP:0100614)3.64682368
18Combined immunodeficiency (HP:0005387)3.61319218
19Pustule (HP:0200039)3.61052413
20Chronic otitis media (HP:0000389)3.57981959
21Hypochromic microcytic anemia (HP:0004840)3.41929172
22Abnormality of T cell physiology (HP:0011840)3.40781781
23Nasal polyposis (HP:0100582)3.38992440
24Meningitis (HP:0001287)3.20978108
25IgG deficiency (HP:0004315)3.16824308
26Encephalitis (HP:0002383)3.09583033
27Thrombocytosis (HP:0001894)3.07081747
28Recurrent bacterial skin infections (HP:0005406)3.05793230
29Recurrent skin infections (HP:0001581)3.02852547
30Abnormality of the nasal mucosa (HP:0000433)2.98968580
31Inflammation of the large intestine (HP:0002037)2.97954714
32Thyroiditis (HP:0100646)2.96913255
33Gastrointestinal inflammation (HP:0004386)2.93198138
34Hypoplasia of the thymus (HP:0000778)2.91616494
35Petechiae (HP:0000967)2.90768160
36Episodic fever (HP:0001954)2.90126114
37Colitis (HP:0002583)2.88348328
38Hypochromic anemia (HP:0001931)2.78172263
39Epistaxis (HP:0000421)2.70831600
40Abnormality of macrophages (HP:0004311)2.69455511
41Vasculitis (HP:0002633)2.68427707
42Recurrent gram-negative bacterial infections (HP:0005420)2.64701183
43Abnormality of eosinophils (HP:0001879)2.64223770
44Lymphopenia (HP:0001888)2.61032840
45Abnormality of B cell number (HP:0010975)2.56347281
46B lymphocytopenia (HP:0010976)2.56347281
47Chest pain (HP:0100749)2.55909171
48Urticaria (HP:0001025)2.54499312
49Prolonged bleeding time (HP:0003010)2.54298626
50Mediastinal lymphadenopathy (HP:0100721)2.46722415
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.44765294
52Abnormality of the heme biosynthetic pathway (HP:0010472)2.44707151
53Chronic diarrhea (HP:0002028)2.44575214
54Abnormality of the pleura (HP:0002103)2.39857111
55Stomatitis (HP:0010280)2.39279221
56Impaired platelet aggregation (HP:0003540)2.38911667
57Abnormal platelet function (HP:0011869)2.38911667
58Acute hepatic failure (HP:0006554)2.38607463
59Orchitis (HP:0100796)2.37957061
60Stomach cancer (HP:0012126)2.37381484
61Joint swelling (HP:0001386)2.36854947
62Retrobulbar optic neuritis (HP:0100654)2.35395903
63Optic neuritis (HP:0100653)2.35395903
64Leukocytosis (HP:0001974)2.35320403
65Recurrent sinusitis (HP:0011108)2.35101179
66Lymphoma (HP:0002665)2.35058499
67Pulmonary infiltrates (HP:0002113)2.34495355
68Autoimmune thrombocytopenia (HP:0001973)2.33284722
69Reduced antithrombin III activity (HP:0001976)2.32829695
70Hemoptysis (HP:0002105)2.32308310
71Type 2 muscle fiber atrophy (HP:0003554)2.31531576
72Obstructive lung disease (HP:0006536)2.31413963
73Chronic obstructive pulmonary disease (HP:0006510)2.31413963
74Abnormal rod and cone electroretinograms (HP:0008323)2.30416624
75Bronchitis (HP:0012387)2.28426992
76Gingivitis (HP:0000230)2.27033928
77Gastrointestinal infarctions (HP:0005244)2.26081276
78Neutropenia (HP:0001875)2.25309124
79Congenital stationary night blindness (HP:0007642)2.24630125
80Verrucae (HP:0200043)2.22873923
81Papilloma (HP:0012740)2.22873923
82Pancreatic cysts (HP:0001737)2.22078155
83Muscle fiber atrophy (HP:0100295)2.21302948
84Microcytic anemia (HP:0001935)2.19491430
85Arterial thrombosis (HP:0004420)2.19125147
86Spontaneous hematomas (HP:0007420)2.18569161
87Gingival bleeding (HP:0000225)2.15998974
88Keratoconjunctivitis sicca (HP:0001097)2.15590084
89Type I transferrin isoform profile (HP:0003642)2.13195933
90Vacuolated lymphocytes (HP:0001922)2.11849541
91Abnormality of the prostate (HP:0008775)2.10553090
92Chronic sinusitis (HP:0011109)2.10458119
93Granulocytopenia (HP:0001913)2.09252884
94Gastrointestinal stroma tumor (HP:0100723)2.07584002
95Gangrene (HP:0100758)2.07482635
96Eosinophilia (HP:0001880)2.04654494
97Ragged-red muscle fibers (HP:0003200)2.04395037
98Skin rash (HP:0000988)2.02772131
99Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02617736
100Poikilocytosis (HP:0004447)2.02338206
101Pulmonary embolism (HP:0002204)2.01880989
102Keratitis (HP:0000491)2.01359785
103Acne (HP:0001061)2.00934922
104Absent/shortened dynein arms (HP:0200106)2.00140343
105Dynein arm defect of respiratory motile cilia (HP:0012255)2.00140343
106Abnormality of transition element cation homeostasis (HP:0011030)1.98627611
107Peritonitis (HP:0002586)1.98021009
108Periodontitis (HP:0000704)1.97869333
109Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.94728986
110Decreased activity of mitochondrial respiratory chain (HP:0008972)1.94728986
111Anorexia (HP:0002039)1.94507921
112Increased IgM level (HP:0003496)1.94251062
113Keratoconjunctivitis (HP:0001096)1.93260114
114Abnormal platelet volume (HP:0011876)1.93122583
115Albinism (HP:0001022)1.91646209
116Increased IgE level (HP:0003212)1.90690582
117Cellulitis (HP:0100658)1.90504823
118Aplastic anemia (HP:0001915)1.90493518
119Increased serum ferritin (HP:0003281)1.89577396
120Skin ulcer (HP:0200042)1.89487192
121Cheilitis (HP:0100825)1.88295609
122Abnormality of iron homeostasis (HP:0011031)1.87489612
123Vertigo (HP:0002321)1.86516174
124Polyneuropathy (HP:0001271)1.82205950
125Alveolar cell carcinoma (HP:0006519)1.78623234
126Attenuation of retinal blood vessels (HP:0007843)1.78387625
127Autoimmune hemolytic anemia (HP:0001890)1.75931452
128Abnormality of liposaccharide metabolism (HP:0010968)1.75761443
129Abnormality of glycosphingolipid metabolism (HP:0004343)1.75761443
130Abnormality of glycolipid metabolism (HP:0010969)1.75761443
131Abnormality of the pericardium (HP:0001697)1.73763811
132Neoplasm of the tracheobronchial system (HP:0100552)1.72594561
133Hypothermia (HP:0002045)1.71734282
134Osteomyelitis (HP:0002754)1.71574805
135Amyloidosis (HP:0011034)1.71330019
136Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71193491
137Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71193491

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.30052613
2TXK3.95549161
3FRK3.23813743
4ITK2.89617506
5ZAP702.79808362
6TYK22.68696951
7IKBKE2.46496292
8IRAK42.41824133
9FLT32.40585739
10JAK32.39245104
11GRK62.36581425
12TEC2.34812635
13TAOK32.20642852
14KIT2.13495522
15TBK12.11956791
16BTK1.95045942
17FGFR41.90503473
18MAP3K141.88162251
19JAK11.84831162
20KDR1.84532992
21SYK1.81810538
22STK101.76432163
23BLK1.72157693
24PKN21.69326819
25IKBKB1.54071081
26CSF1R1.50995492
27MAP3K121.47255746
28LCK1.47116865
29EPHB11.46015705
30IRAK11.41288775
31NME21.36077530
32MAP3K21.32163985
33MST41.26218002
34CSK1.25934007
35MAP2K31.21557271
36NEK91.21252775
37HCK1.16683186
38CAMKK21.14124858
39TLK11.12984007
40MAP4K21.12927925
41OXSR11.12592079
42FGR1.12568818
43NLK1.12304142
44PIM11.09577045
45GRK11.06828202
46DAPK21.06735403
47MAPK111.05508928
48WNK31.04462034
49PIK3CG1.03792976
50PIM21.03626201
51TGFBR11.02959164
52PINK11.02362587
53LRRK20.99805711
54ERN10.99727380
55IRAK30.99528920
56INSRR0.98383979
57MAPK130.97828682
58LYN0.97692789
59TGFBR20.95985561
60ACVR1B0.94851322
61TESK20.93390548
62TAOK10.93217090
63FGFR30.91279369
64MAP3K130.91212526
65YES10.89844799
66PAK30.89082461
67PRKCQ0.88820726
68PTK2B0.88106753
69STK240.87454391
70JAK20.87271739
71MAP3K100.86507836
72MAP2K40.82674138
73EEF2K0.81073287
74TSSK60.80971122
75TRPM70.79566924
76MYLK0.79408773
77IRAK20.78638060
78EPHA30.78557978
79MAP3K10.76959003
80SIK30.76945518
81ADRBK10.75375376
82MAP2K60.74979536
83ADRBK20.73861247
84FES0.71930538
85BMPR20.70728854
86STK160.68774261
87PRKD20.68715288
88CLK10.67625532
89MATK0.66901314
90PDK10.66737160
91PASK0.65293323
92CHUK0.64026946
93TNK20.63281812
94STK110.63022464
95RAF10.63004148
96GRK70.61770115
97MAP3K70.61446299
98MAP3K30.60891589
99KSR20.59684967
100RIPK40.59500104
101MAP3K60.54613170
102RPS6KA60.54432676
103STK40.54401537
104BCKDK0.53527114
105EIF2AK10.52023732
106RPS6KA40.51805828
107MAPK120.50468145
108ZAK0.49406437
109CDK40.47892709
110SCYL20.45292556
111CDK80.45230427
112HIPK20.44965047
113STK380.44358551
114CAMK40.43806078
115EIF2AK30.43099503
116PTK60.42868689
117RPS6KB20.42812098
118RPS6KL10.42282019
119RPS6KC10.42282019
120PRKCH0.41247077
121MAP3K50.40766444
122PRKCD0.40182808
123FYN0.39893260
124ABL10.39687815
125MAPK70.38809710
126MAP3K110.37628965
127PRKCZ0.37030983
128MARK20.36465943
129TRIB30.35875766
130PRKAA20.35687135
131DAPK10.34763833
132TIE10.33957698
133MAP2K20.32725010
134NUAK10.32364245
135CAMKK10.32287030
136MARK30.31823870
137FER0.31545418
138MAPKAPK20.31364760
139ILK0.30858447
140BMPR1B0.30801812
141CDC42BPA0.29828116
142MAPK30.29824890
143MAPK40.29449697
144TAOK20.27509916
145NEK20.26488238
146SIK20.24623969
147MAPKAPK30.24595969
148BUB10.24527208

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.16052541
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.67443346
3Antigen processing and presentation_Homo sapiens_hsa046122.66832405
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.65998803
5T cell receptor signaling pathway_Homo sapiens_hsa046602.41121375
6Measles_Homo sapiens_hsa051622.37192871
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.34395261
8Caffeine metabolism_Homo sapiens_hsa002322.22672012
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.18854386
10Leishmaniasis_Homo sapiens_hsa051402.07232447
11B cell receptor signaling pathway_Homo sapiens_hsa046622.01207235
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95522802
13Allograft rejection_Homo sapiens_hsa053301.95178677
14Asthma_Homo sapiens_hsa053101.89788231
15Proteasome_Homo sapiens_hsa030501.85361590
16Hematopoietic cell lineage_Homo sapiens_hsa046401.81532922
17Base excision repair_Homo sapiens_hsa034101.73552932
18DNA replication_Homo sapiens_hsa030301.71216326
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60762724
20Graft-versus-host disease_Homo sapiens_hsa053321.60142947
21Herpes simplex infection_Homo sapiens_hsa051681.52549770
22Osteoclast differentiation_Homo sapiens_hsa043801.44713014
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.44652127
24Ribosome_Homo sapiens_hsa030101.35168542
25Other glycan degradation_Homo sapiens_hsa005111.29514912
26Linoleic acid metabolism_Homo sapiens_hsa005911.29488548
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28753974
28Phagosome_Homo sapiens_hsa041451.28268769
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26795495
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.25383999
31Pentose phosphate pathway_Homo sapiens_hsa000301.24327039
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.24243330
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.22146791
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17177981
35Toxoplasmosis_Homo sapiens_hsa051451.16874727
36Mismatch repair_Homo sapiens_hsa034301.15602904
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.12064838
38Staphylococcus aureus infection_Homo sapiens_hsa051501.10036752
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09424628
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08821709
41Influenza A_Homo sapiens_hsa051641.08559850
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08130373
43Regulation of autophagy_Homo sapiens_hsa041401.06451645
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05194117
45Collecting duct acid secretion_Homo sapiens_hsa049661.03626221
46Shigellosis_Homo sapiens_hsa051311.03184642
47Apoptosis_Homo sapiens_hsa042101.03157458
48Acute myeloid leukemia_Homo sapiens_hsa052211.03140814
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02683230
50Ether lipid metabolism_Homo sapiens_hsa005651.00071706
51Legionellosis_Homo sapiens_hsa051340.97929432
52Viral myocarditis_Homo sapiens_hsa054160.97524901
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95724588
54African trypanosomiasis_Homo sapiens_hsa051430.94743768
55RNA polymerase_Homo sapiens_hsa030200.94348532
56Arachidonic acid metabolism_Homo sapiens_hsa005900.94073795
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92634427
58Pyrimidine metabolism_Homo sapiens_hsa002400.92611134
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.91680656
60Nitrogen metabolism_Homo sapiens_hsa009100.90656774
61Hepatitis B_Homo sapiens_hsa051610.90099592
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90093860
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89526447
64Epstein-Barr virus infection_Homo sapiens_hsa051690.88831639
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86212582
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84884896
67Chemokine signaling pathway_Homo sapiens_hsa040620.83070555
68Autoimmune thyroid disease_Homo sapiens_hsa053200.82978175
69Homologous recombination_Homo sapiens_hsa034400.82643571
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82116598
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81712876
72ABC transporters_Homo sapiens_hsa020100.81553726
73Non-homologous end-joining_Homo sapiens_hsa034500.81267167
74Type I diabetes mellitus_Homo sapiens_hsa049400.81104097
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77319965
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76036549
77Malaria_Homo sapiens_hsa051440.75028251
78Folate biosynthesis_Homo sapiens_hsa007900.74836554
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74681935
80Nucleotide excision repair_Homo sapiens_hsa034200.72868424
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71341730
82Dorso-ventral axis formation_Homo sapiens_hsa043200.71191388
83Lysosome_Homo sapiens_hsa041420.71020486
84Oxidative phosphorylation_Homo sapiens_hsa001900.70325015
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.69942483
86Tuberculosis_Homo sapiens_hsa051520.69915807
87Phototransduction_Homo sapiens_hsa047440.69140079
88Chemical carcinogenesis_Homo sapiens_hsa052040.68901356
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66781052
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66769573
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66304922
92Butanoate metabolism_Homo sapiens_hsa006500.66020319
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65670709
94Hepatitis C_Homo sapiens_hsa051600.65385873
95Protein export_Homo sapiens_hsa030600.65319243
96Platelet activation_Homo sapiens_hsa046110.63025206
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62432939
98Sulfur relay system_Homo sapiens_hsa041220.60329777
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59435261
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58301873
101Peroxisome_Homo sapiens_hsa041460.57962054
102TNF signaling pathway_Homo sapiens_hsa046680.57624817
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.57606350
104Pertussis_Homo sapiens_hsa051330.55756587
105Carbon metabolism_Homo sapiens_hsa012000.53113399
106Galactose metabolism_Homo sapiens_hsa000520.52665654
107Sulfur metabolism_Homo sapiens_hsa009200.52189601
108Non-small cell lung cancer_Homo sapiens_hsa052230.51173808
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51142134
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49439857
111Spliceosome_Homo sapiens_hsa030400.49251980
112RNA degradation_Homo sapiens_hsa030180.48552121
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48348442
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47566661
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47449996
116Tryptophan metabolism_Homo sapiens_hsa003800.46809334
117p53 signaling pathway_Homo sapiens_hsa041150.45391257
118Fatty acid degradation_Homo sapiens_hsa000710.44560328
119Selenocompound metabolism_Homo sapiens_hsa004500.44364724
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43876003
121HTLV-I infection_Homo sapiens_hsa051660.43545579
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42946767
123Fructose and mannose metabolism_Homo sapiens_hsa000510.42534925
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.42450282
125Retinol metabolism_Homo sapiens_hsa008300.42081818
126Vitamin B6 metabolism_Homo sapiens_hsa007500.40752594
127N-Glycan biosynthesis_Homo sapiens_hsa005100.40729051
128Viral carcinogenesis_Homo sapiens_hsa052030.39747261
129Rheumatoid arthritis_Homo sapiens_hsa053230.39147002
130Parkinsons disease_Homo sapiens_hsa050120.39142150
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39104625
132Glycerolipid metabolism_Homo sapiens_hsa005610.38947918
133beta-Alanine metabolism_Homo sapiens_hsa004100.38947689
134One carbon pool by folate_Homo sapiens_hsa006700.37969561
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.34608387
136Prolactin signaling pathway_Homo sapiens_hsa049170.34414920
137FoxO signaling pathway_Homo sapiens_hsa040680.34293320
138Insulin resistance_Homo sapiens_hsa049310.32919301
139Serotonergic synapse_Homo sapiens_hsa047260.31804586
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.30188677
141Complement and coagulation cascades_Homo sapiens_hsa046100.29012899
142Mineral absorption_Homo sapiens_hsa049780.28530841

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