MPPED2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene likely encodes a metallophosphoesterase. The encoded protein may play a role a brain development. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)4.79417857
2pyrimidine nucleobase catabolic process (GO:0006208)4.45287077
3vocalization behavior (GO:0071625)4.36780594
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.36405057
5neuron recognition (GO:0008038)4.30843773
6cell migration in hindbrain (GO:0021535)4.29440124
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.13414915
8axonal fasciculation (GO:0007413)4.04630145
9regulation of glutamate receptor signaling pathway (GO:1900449)4.00932533
10limb bud formation (GO:0060174)3.98758840
11protein localization to synapse (GO:0035418)3.95496549
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.89994181
13central nervous system projection neuron axonogenesis (GO:0021952)3.86960467
14DNA double-strand break processing (GO:0000729)3.85467976
15synaptic vesicle exocytosis (GO:0016079)3.77312694
16dendritic spine morphogenesis (GO:0060997)3.76473163
17ionotropic glutamate receptor signaling pathway (GO:0035235)3.72032423
18layer formation in cerebral cortex (GO:0021819)3.68891681
19behavioral response to nicotine (GO:0035095)3.68248608
20regulation of synapse structural plasticity (GO:0051823)3.62159586
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.61058820
22olfactory bulb development (GO:0021772)3.48974671
23negative regulation of microtubule polymerization (GO:0031115)3.48106899
24ATP synthesis coupled proton transport (GO:0015986)3.45628139
25energy coupled proton transport, down electrochemical gradient (GO:0015985)3.45628139
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.45035686
27glutamate receptor signaling pathway (GO:0007215)3.41035816
28nucleobase catabolic process (GO:0046113)3.40772568
29synaptic vesicle maturation (GO:0016188)3.39153570
30regulation of synaptic vesicle exocytosis (GO:2000300)3.37432265
31cerebral cortex radially oriented cell migration (GO:0021799)3.35243511
32locomotory exploration behavior (GO:0035641)3.31754979
33synaptic transmission, glutamatergic (GO:0035249)3.30723716
34nonmotile primary cilium assembly (GO:0035058)3.28713310
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.27371724
36exploration behavior (GO:0035640)3.25107327
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22961701
38dendrite morphogenesis (GO:0048813)3.20886864
39glutamate secretion (GO:0014047)3.20676333
40neural tube formation (GO:0001841)3.20313737
41neuron-neuron synaptic transmission (GO:0007270)3.20189535
42regulation of dendritic spine morphogenesis (GO:0061001)3.15834419
43C4-dicarboxylate transport (GO:0015740)3.14497064
44hippocampus development (GO:0021766)3.14149654
45regulation of development, heterochronic (GO:0040034)3.13686047
46retinal ganglion cell axon guidance (GO:0031290)3.13147984
47cell communication by electrical coupling (GO:0010644)3.10331795
48positive regulation of synapse assembly (GO:0051965)3.09128852
49startle response (GO:0001964)3.08906896
50regulation of timing of cell differentiation (GO:0048505)3.08525823
51postsynaptic membrane organization (GO:0001941)3.08439864
52regulation of neuronal synaptic plasticity (GO:0048168)3.07988685
53regulation of synaptic vesicle transport (GO:1902803)3.07342803
54negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07156286
55transmission of nerve impulse (GO:0019226)3.06690504
56auditory behavior (GO:0031223)3.02790194
57positive regulation of synapse maturation (GO:0090129)3.01692867
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.01523551
59glycosphingolipid biosynthetic process (GO:0006688)3.00717356
60somite development (GO:0061053)2.99590411
61regulation of long-term neuronal synaptic plasticity (GO:0048169)2.99424481
62presynaptic membrane assembly (GO:0097105)2.98247876
63neurotransmitter-gated ion channel clustering (GO:0072578)2.97621610
64synapse assembly (GO:0007416)2.96555629
65cerebral cortex cell migration (GO:0021795)2.96042270
66positive regulation of mitochondrial fission (GO:0090141)2.95357576
67behavioral defense response (GO:0002209)2.95206118
68behavioral fear response (GO:0001662)2.95206118
69central nervous system neuron axonogenesis (GO:0021955)2.94342716
70protein polyglutamylation (GO:0018095)2.91435927
71prepulse inhibition (GO:0060134)2.91229928
72regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90158267
73dendrite development (GO:0016358)2.88888869
74head development (GO:0060322)2.88782543
75regulation of synapse assembly (GO:0051963)2.88640698
76positive regulation of dendritic spine morphogenesis (GO:0061003)2.88638890
77negative regulation of dendrite development (GO:2000171)2.88508725
78neuronal action potential propagation (GO:0019227)2.88047911
79epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.86651621
80neurotransmitter secretion (GO:0007269)2.86060430
81innervation (GO:0060384)2.85786554
82intraciliary transport (GO:0042073)2.82598610
83behavioral response to cocaine (GO:0048148)2.81018390
84regulation of respiratory system process (GO:0044065)2.79868279
85behavioral response to ethanol (GO:0048149)2.78887853
86synaptic vesicle docking involved in exocytosis (GO:0016081)2.78717141
87regulation of synapse organization (GO:0050807)2.78507666
88negative regulation of translation, ncRNA-mediated (GO:0040033)2.76491635
89regulation of translation, ncRNA-mediated (GO:0045974)2.76491635
90negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.76491635
91negative regulation of transcription regulatory region DNA binding (GO:2000678)2.75980937
92cerebellum development (GO:0021549)2.75739880
93fear response (GO:0042596)2.75503051
94presynaptic membrane organization (GO:0097090)2.75444603
95regulation of excitatory postsynaptic membrane potential (GO:0060079)2.74851613
96establishment of mitochondrion localization (GO:0051654)2.74660981
97regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.73274100
98gamma-aminobutyric acid transport (GO:0015812)2.73053707
99retinal cone cell development (GO:0046549)2.72944497
100regulation of dopamine metabolic process (GO:0042053)2.72051129
101regulation of catecholamine metabolic process (GO:0042069)2.72051129
102chaperone-mediated protein transport (GO:0072321)2.71867476
103positive regulation of synaptic transmission, GABAergic (GO:0032230)2.70208095
104spinal cord development (GO:0021510)2.69748957
105negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69613992
106regulation of postsynaptic membrane potential (GO:0060078)2.69538728
107dendritic spine organization (GO:0097061)2.67985104
108replication fork processing (GO:0031297)2.67507958
109G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.66886033
110cerebellar Purkinje cell differentiation (GO:0021702)2.65714100
111substrate-independent telencephalic tangential migration (GO:0021826)2.65546438
112substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.65546438
113centriole replication (GO:0007099)2.64156672
114mechanosensory behavior (GO:0007638)2.62724887
115striatum development (GO:0021756)2.62442066
116sympathetic nervous system development (GO:0048485)2.62322458
117adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.62264060
118dopamine receptor signaling pathway (GO:0007212)2.61968612
119regulation of collateral sprouting (GO:0048670)2.61101812
120regulation of synapse maturation (GO:0090128)2.60544443
121regulation of vesicle fusion (GO:0031338)2.59771040
122cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.59413007
123neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.59349330
124cell proliferation in forebrain (GO:0021846)2.59256564
125synapse organization (GO:0050808)2.58877212
126hindbrain development (GO:0030902)2.58531475
127axon extension (GO:0048675)2.58453306
128adult walking behavior (GO:0007628)2.57890496
129otic vesicle formation (GO:0030916)2.57234117
130negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56218782
131long-term memory (GO:0007616)2.55997035
132cardiac ventricle formation (GO:0003211)2.55304316
133regulation of dendritic spine development (GO:0060998)2.54982562
134membrane depolarization during action potential (GO:0086010)2.54817507
135regulation of dendrite morphogenesis (GO:0048814)2.54056264
136positive regulation of dendritic spine development (GO:0060999)2.54008385
137positive regulation of membrane potential (GO:0045838)2.53998413
138epithelial cilium movement (GO:0003351)2.49963504
139protein localization to cilium (GO:0061512)2.48579640
140cilium assembly (GO:0042384)2.47958239
141cilium organization (GO:0044782)2.47928671
142regulation of cilium movement (GO:0003352)2.47251206
143cardiac chamber formation (GO:0003207)2.46813764
144microtubule depolymerization (GO:0007019)2.46773941
145inner ear receptor stereocilium organization (GO:0060122)2.40638662
146calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.39381348
147neuronal action potential (GO:0019228)2.39107086
148cilium morphogenesis (GO:0060271)2.38346357
149cilium movement (GO:0003341)2.37611485
150regulation of action potential (GO:0098900)2.37601151
151regulation of telomere maintenance (GO:0032204)2.37104413
152microtubule polymerization or depolymerization (GO:0031109)2.36549187
153positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.36411252
154tongue development (GO:0043586)2.35738852
155detection of light stimulus involved in visual perception (GO:0050908)2.35738173
156detection of light stimulus involved in sensory perception (GO:0050962)2.35738173
157microtubule anchoring (GO:0034453)2.35298914
158kidney morphogenesis (GO:0060993)2.35207253
159histone H2A acetylation (GO:0043968)2.34571109
160response to auditory stimulus (GO:0010996)2.34296089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.98067573
2GBX2_23144817_ChIP-Seq_PC3_Human3.35676806
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09214356
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.99960617
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98665643
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91761903
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76058522
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76058522
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.72918600
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69126597
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.62809303
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.56337479
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47678283
14* REST_21632747_ChIP-Seq_MESCs_Mouse2.47178828
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46185844
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.46108534
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45754312
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39069604
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.29232087
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24353457
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23391666
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.18335349
23CBX2_27304074_Chip-Seq_ESCs_Mouse2.14213195
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13932907
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09011655
26* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03599586
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98212920
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.97001385
29* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96786174
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.95932290
31* RARB_27405468_Chip-Seq_BRAIN_Mouse1.92749322
32TAF15_26573619_Chip-Seq_HEK293_Human1.90137879
33ZNF274_21170338_ChIP-Seq_K562_Hela1.87693220
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80625309
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79579289
36IGF1R_20145208_ChIP-Seq_DFB_Human1.76962445
37RNF2_27304074_Chip-Seq_NSC_Mouse1.73452320
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71351504
39* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.71048825
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67667635
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59182836
42DROSHA_22980978_ChIP-Seq_HELA_Human1.59016232
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.58446203
44* P300_19829295_ChIP-Seq_ESCs_Human1.49590326
45ER_23166858_ChIP-Seq_MCF-7_Human1.49488268
46* RING1B_27294783_Chip-Seq_ESCs_Mouse1.43927038
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42633675
48SMAD4_21799915_ChIP-Seq_A2780_Human1.42172275
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40176302
50FUS_26573619_Chip-Seq_HEK293_Human1.39941624
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39716895
52VDR_22108803_ChIP-Seq_LS180_Human1.36435094
53* RING1B_27294783_Chip-Seq_NPCs_Mouse1.36061416
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.35510636
55* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33524173
56BCAT_22108803_ChIP-Seq_LS180_Human1.33128838
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.31825241
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31414974
59* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30674258
60IRF1_19129219_ChIP-ChIP_H3396_Human1.29429236
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28024053
62CBP_20019798_ChIP-Seq_JUKART_Human1.28024053
63* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26930835
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24866336
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24583766
66AR_21572438_ChIP-Seq_LNCaP_Human1.22986135
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20983345
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19775246
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19571292
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.19362858
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18086155
72TCF4_22108803_ChIP-Seq_LS180_Human1.17853834
73* NANOG_18555785_Chip-Seq_ESCs_Mouse1.16843754
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16313479
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.16219651
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15444517
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15246467
78* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14401247
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13725458
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13533786
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.12825362
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12744547
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12449611
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11956706
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11956706
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.11510931
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10884086
88* AR_25329375_ChIP-Seq_VCAP_Human1.10024552
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09465822
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09282895
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07812371
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07364101
93KDM2B_26808549_Chip-Seq_REH_Human1.07335491
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07200274
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06973192
96* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06711072
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06669257
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.06575867
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.06558426
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06037114
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.05132720
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04923671
103* AR_19668381_ChIP-Seq_PC3_Human1.04353156
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04003089
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02684488
106* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02454841
107* SOX9_26525672_Chip-Seq_HEART_Mouse1.02325156
108* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02243647
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02165523
110YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01373983
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00995188
112RUNX2_22187159_ChIP-Seq_PCA_Human1.00656026
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.00618147
114P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98649687
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98383344
116EP300_21415370_ChIP-Seq_HL-1_Mouse0.97468478
117* STAT3_23295773_ChIP-Seq_U87_Human0.97298169
118* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95972286
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95113917
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94711556
121CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93163789
122EWS_26573619_Chip-Seq_HEK293_Human0.92645727
123* ISL1_27105846_Chip-Seq_CPCs_Mouse0.92308849
124JUN_21703547_ChIP-Seq_K562_Human0.92068374
125ARNT_22903824_ChIP-Seq_MCF-7_Human0.92004594
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90822574
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90478326
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89514280
129* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88182893
130TCF4_23295773_ChIP-Seq_U87_Human0.86979846
131MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86809357
132AHR_22903824_ChIP-Seq_MCF-7_Human0.86415571
133* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85700523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.45977355
2MP0004859_abnormal_synaptic_plasticity4.30191015
3MP0003635_abnormal_synaptic_transmissio3.06477674
4MP0004270_analgesia2.85576442
5MP0002063_abnormal_learning/memory/cond2.69451734
6MP0006276_abnormal_autonomic_nervous2.67948975
7MP0003122_maternal_imprinting2.55319192
8MP0001968_abnormal_touch/_nociception2.55246400
9MP0005423_abnormal_somatic_nervous2.50867965
10MP0009745_abnormal_behavioral_response2.48799027
11MP0000778_abnormal_nervous_system2.48401507
12MP0002572_abnormal_emotion/affect_behav2.28275600
13MP0002735_abnormal_chemical_nociception2.23369366
14MP0002734_abnormal_mechanical_nocicepti2.20289352
15MP0001529_abnormal_vocalization2.18443847
16MP0002064_seizures2.15114477
17MP0002184_abnormal_innervation2.04248455
18MP0001486_abnormal_startle_reflex1.99046237
19MP0002736_abnormal_nociception_after1.91436663
20MP0002733_abnormal_thermal_nociception1.88532616
21MP0009046_muscle_twitch1.81365107
22MP0002272_abnormal_nervous_system1.81247555
23MP0002557_abnormal_social/conspecific_i1.78036220
24MP0001440_abnormal_grooming_behavior1.73906913
25MP0000566_synostosis1.71856301
26MP0001970_abnormal_pain_threshold1.69220569
27MP0002067_abnormal_sensory_capabilities1.67304013
28MP0003787_abnormal_imprinting1.66386512
29MP0001905_abnormal_dopamine_level1.65954336
30MP0006292_abnormal_olfactory_placode1.61843224
31MP0005253_abnormal_eye_physiology1.61830651
32MP0008877_abnormal_DNA_methylation1.60733005
33MP0005386_behavior/neurological_phenoty1.58802888
34MP0004924_abnormal_behavior1.58802888
35MP0003121_genomic_imprinting1.56355225
36MP0004811_abnormal_neuron_physiology1.53784143
37MP0002837_dystrophic_cardiac_calcinosis1.48575071
38MP0001188_hyperpigmentation1.47080529
39MP0000955_abnormal_spinal_cord1.44701106
40MP0000751_myopathy1.41540990
41MP0003137_abnormal_impulse_conducting1.40323893
42MP0002882_abnormal_neuron_morphology1.40323328
43MP0002638_abnormal_pupillary_reflex1.40234087
44MP0002909_abnormal_adrenal_gland1.40215224
45MP0002233_abnormal_nose_morphology1.38494230
46MP0000631_abnormal_neuroendocrine_gland1.38348376
47MP0000569_abnormal_digit_pigmentation1.37106784
48MP0004858_abnormal_nervous_system1.35568079
49MP0004145_abnormal_muscle_electrophysio1.32082410
50MP0002822_catalepsy1.29773354
51MP0001984_abnormal_olfaction1.29376298
52MP0004085_abnormal_heartbeat1.27697146
53MP0002751_abnormal_autonomic_nervous1.26690397
54MP0002152_abnormal_brain_morphology1.24440051
55MP0004215_abnormal_myocardial_fiber1.23499734
56MP0001501_abnormal_sleep_pattern1.20907733
57MP0005499_abnormal_olfactory_system1.20794026
58MP0005394_taste/olfaction_phenotype1.20794026
59MP0005646_abnormal_pituitary_gland1.19406212
60MP0002066_abnormal_motor_capabilities/c1.15338588
61MP0003861_abnormal_nervous_system1.14883695
62MP0003937_abnormal_limbs/digits/tail_de1.14610522
63MP0005409_darkened_coat_color1.11346759
64MP0000049_abnormal_middle_ear1.10040940
65MP0003385_abnormal_body_wall1.09527931
66MP0001293_anophthalmia1.08905544
67MP0005195_abnormal_posterior_eye1.08615518
68MP0002234_abnormal_pharynx_morphology1.08096897
69MP0008789_abnormal_olfactory_epithelium1.06334157
70MP0001502_abnormal_circadian_rhythm1.04588293
71MP0005187_abnormal_penis_morphology1.03873758
72MP0005391_vision/eye_phenotype1.03208380
73MP0002752_abnormal_somatic_nervous1.02250902
74MP0003755_abnormal_palate_morphology1.01457217
75MP0000537_abnormal_urethra_morphology0.99386847
76MP0004885_abnormal_endolymph0.97619957
77MP0010386_abnormal_urinary_bladder0.97600450
78MP0002102_abnormal_ear_morphology0.97514899
79MP0008569_lethality_at_weaning0.97262176
80MP0004043_abnormal_pH_regulation0.96737106
81MP0008058_abnormal_DNA_repair0.96010157
82MP0002653_abnormal_ependyma_morphology0.95679981
83MP0004142_abnormal_muscle_tone0.95411838
84MP0003890_abnormal_embryonic-extraembry0.95008816
85MP0006072_abnormal_retinal_apoptosis0.94609845
86MP0004084_abnormal_cardiac_muscle0.94295249
87MP0008872_abnormal_physiological_respon0.94148798
88MP0010030_abnormal_orbit_morphology0.94080804
89MP0003136_yellow_coat_color0.93430318
90MP0003123_paternal_imprinting0.93009300
91MP0005551_abnormal_eye_electrophysiolog0.91962214
92MP0001177_atelectasis0.91663403
93MP0005645_abnormal_hypothalamus_physiol0.91433193
94MP0003567_abnormal_fetal_cardiomyocyte0.90750863
95MP0003119_abnormal_digestive_system0.90253485
96MP0000026_abnormal_inner_ear0.86393602
97MP0001286_abnormal_eye_development0.85513516
98MP0005367_renal/urinary_system_phenotyp0.83776883
99MP0000516_abnormal_urinary_system0.83776883
100MP0000427_abnormal_hair_cycle0.83680737
101MP0001346_abnormal_lacrimal_gland0.83531865
102MP0004742_abnormal_vestibular_system0.83442126
103MP0002249_abnormal_larynx_morphology0.81788534
104MP0001485_abnormal_pinna_reflex0.81461444
105MP0005620_abnormal_muscle_contractility0.80676658
106MP0003942_abnormal_urinary_system0.80502788
107MP0002282_abnormal_trachea_morphology0.80043792
108MP0000534_abnormal_ureter_morphology0.79799428
109MP0001963_abnormal_hearing_physiology0.79131924
110MP0004133_heterotaxia0.79040661
111MP0005248_abnormal_Harderian_gland0.78975846
112MP0003315_abnormal_perineum_morphology0.78834889
113MP0002972_abnormal_cardiac_muscle0.78709916
114MP0003938_abnormal_ear_development0.78690860
115MP0002069_abnormal_eating/drinking_beha0.78531265
116MP0005171_absent_coat_pigmentation0.78350256
117MP0003698_abnormal_male_reproductive0.76695331
118MP0004036_abnormal_muscle_relaxation0.76490305
119MP0009250_abnormal_appendicular_skeleto0.75261876
120MP0003879_abnormal_hair_cell0.73678497
121MP0000647_abnormal_sebaceous_gland0.73254804
122MP0002938_white_spotting0.71682174
123MP0002127_abnormal_cardiovascular_syste0.71215495
124MP0001299_abnormal_eye_distance/0.70022017

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.96995536
2Myokymia (HP:0002411)4.77258611
3Limb dystonia (HP:0002451)4.10629958
4Focal seizures (HP:0007359)3.79467047
5True hermaphroditism (HP:0010459)3.72195672
6Epileptic encephalopathy (HP:0200134)3.54646812
7Pancreatic cysts (HP:0001737)3.31374575
8Abnormality of midbrain morphology (HP:0002418)3.31182751
9Molar tooth sign on MRI (HP:0002419)3.31182751
10Visual hallucinations (HP:0002367)3.29415233
11Pancreatic fibrosis (HP:0100732)3.21220327
12Febrile seizures (HP:0002373)3.19274667
13Nephronophthisis (HP:0000090)3.02867328
14Congenital primary aphakia (HP:0007707)3.02571419
15Nephrogenic diabetes insipidus (HP:0009806)2.95835992
16Progressive cerebellar ataxia (HP:0002073)2.93392799
17Amblyopia (HP:0000646)2.87891901
18Broad-based gait (HP:0002136)2.82989627
19Acute necrotizing encephalopathy (HP:0006965)2.78312197
20Pheochromocytoma (HP:0002666)2.74559640
21Vaginal atresia (HP:0000148)2.70714291
22Atonic seizures (HP:0010819)2.70261305
23Hyperventilation (HP:0002883)2.66431472
24Volvulus (HP:0002580)2.64256782
25Drooling (HP:0002307)2.52754579
26Excessive salivation (HP:0003781)2.52754579
27Abnormality of the renal medulla (HP:0100957)2.52743057
28Abnormal mitochondria in muscle tissue (HP:0008316)2.51656428
29Failure to thrive in infancy (HP:0001531)2.50693898
30Progressive macrocephaly (HP:0004481)2.49516905
31Chronic hepatic failure (HP:0100626)2.48792174
32Aplasia/Hypoplasia of the brainstem (HP:0007362)2.47593548
33Hypoplasia of the brainstem (HP:0002365)2.47593548
34Absence seizures (HP:0002121)2.46687773
35Intestinal atresia (HP:0011100)2.45644065
36Postaxial hand polydactyly (HP:0001162)2.37674806
37Neuroendocrine neoplasm (HP:0100634)2.37536924
38Retinal dysplasia (HP:0007973)2.36189368
39Generalized tonic-clonic seizures (HP:0002069)2.35695500
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.35206836
41Epileptiform EEG discharges (HP:0011182)2.34000206
42Dialeptic seizures (HP:0011146)2.30733683
43Oligodactyly (HP:0012165)2.29287634
44EEG with generalized epileptiform discharges (HP:0011198)2.28668336
45Sudden death (HP:0001699)2.27963556
46Poor eye contact (HP:0000817)2.22887129
47Lissencephaly (HP:0001339)2.22087785
48Hypsarrhythmia (HP:0002521)2.18822850
49Optic nerve hypoplasia (HP:0000609)2.17069835
50Polyphagia (HP:0002591)2.16588719
51Rimmed vacuoles (HP:0003805)2.16357544
52Poor coordination (HP:0002370)2.15139939
53Renal hypoplasia (HP:0000089)2.14882933
54Congenital stationary night blindness (HP:0007642)2.14695525
55Type II lissencephaly (HP:0007260)2.14424852
56Anxiety (HP:0000739)2.14378084
57Morphological abnormality of the middle ear (HP:0008609)2.13419208
58Narrow forehead (HP:0000341)2.12379104
59Postaxial foot polydactyly (HP:0001830)2.11929986
60Amyotrophic lateral sclerosis (HP:0007354)2.11649530
61Shoulder girdle muscle weakness (HP:0003547)2.11647931
62Abnormality of the labia minora (HP:0012880)2.09362631
63Colon cancer (HP:0003003)2.09211063
64Broad foot (HP:0001769)2.08331144
65Abnormality of the lower motor neuron (HP:0002366)2.08188903
66Ankle clonus (HP:0011448)2.07796828
67Cortical dysplasia (HP:0002539)2.07523259
68Sclerocornea (HP:0000647)2.06835727
69Cystic liver disease (HP:0006706)2.06755074
70Gait imbalance (HP:0002141)2.06236811
71Megalencephaly (HP:0001355)2.06044293
72Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05280934
73Pachygyria (HP:0001302)2.04937385
74Patellar aplasia (HP:0006443)2.04568052
75Hepatoblastoma (HP:0002884)2.04492898
76Abnormality of the aortic arch (HP:0012303)2.04077764
77Oligodactyly (hands) (HP:0001180)2.02603085
78Dyskinesia (HP:0100660)2.02305399
79Truncus arteriosus (HP:0001660)1.99829285
80Anencephaly (HP:0002323)1.98433226
81Preaxial hand polydactyly (HP:0001177)1.97498424
82Aplasia/Hypoplasia of the tibia (HP:0005772)1.96936582
83Pendular nystagmus (HP:0012043)1.96935832
84Aplasia/Hypoplasia of the sternum (HP:0006714)1.96785798
85Prolonged QT interval (HP:0001657)1.96196405
86Hemiparesis (HP:0001269)1.94117001
87Progressive inability to walk (HP:0002505)1.93608712
88Impaired vibration sensation in the lower limbs (HP:0002166)1.93441393
89Abnormality of the renal cortex (HP:0011035)1.93364662
90Abnormal eating behavior (HP:0100738)1.93146073
91Bony spicule pigmentary retinopathy (HP:0007737)1.92234342
92Hyperglycinemia (HP:0002154)1.91837865
93Sleep apnea (HP:0010535)1.91430219
94Primary atrial arrhythmia (HP:0001692)1.90884987
95Specific learning disability (HP:0001328)1.90869105
96Abnormal hair whorl (HP:0010721)1.90356846
97Abnormality of the pubic bones (HP:0003172)1.90032836
98Hypoplastic pelvis (HP:0008839)1.89014174
99Muscle hypertrophy of the lower extremities (HP:0008968)1.88429049
100Aplasia/Hypoplasia of the patella (HP:0006498)1.88273315
101Facial hemangioma (HP:0000329)1.87586428
102Abnormal EKG (HP:0003115)1.87114575
103Cutaneous finger syndactyly (HP:0010554)1.87049715
104Mitochondrial inheritance (HP:0001427)1.86154037
105Truncal ataxia (HP:0002078)1.85202617
106Stereotypic behavior (HP:0000733)1.84414303
107Short foot (HP:0001773)1.84323317
108Impaired social interactions (HP:0000735)1.84129076
109Abnormal social behavior (HP:0012433)1.84129076
110Acute encephalopathy (HP:0006846)1.84078358
111Calf muscle hypertrophy (HP:0008981)1.83865819
112Generalized hypotonia (HP:0001290)1.83049381
113Hypoplastic iliac wings (HP:0002866)1.82747140
114Decreased testicular size (HP:0008734)1.82721366
115Absent speech (HP:0001344)1.82427760
116Supraventricular tachycardia (HP:0004755)1.82270351
117Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81643787
118Agitation (HP:0000713)1.80667539
119Renal dysplasia (HP:0000110)1.80102531
120Autism (HP:0000717)1.78702619
121Abnormality of the metopic suture (HP:0005556)1.77470774
122Aplasia/Hypoplasia of the lens (HP:0008063)1.76577976
123Occipital encephalocele (HP:0002085)1.76298711
124Atrial fibrillation (HP:0005110)1.76236917
125Protruding tongue (HP:0010808)1.75829621
126Tubulointerstitial nephritis (HP:0001970)1.75629894
127Abnormal ciliary motility (HP:0012262)1.75485596
128Depression (HP:0000716)1.75363174
129Exotropia (HP:0000577)1.74948979
130Supraventricular arrhythmia (HP:0005115)1.74108754
131Male pseudohermaphroditism (HP:0000037)1.73915306
132Gaze-evoked nystagmus (HP:0000640)1.73474285
133Abolished electroretinogram (ERG) (HP:0000550)1.73466549
134Micropenis (HP:0000054)1.73033452
135Aganglionic megacolon (HP:0002251)1.72378970
136Scrotal hypoplasia (HP:0000046)1.72326043
137Hypothermia (HP:0002045)1.72013541
138Gastroesophageal reflux (HP:0002020)1.71803824
139Abnormality of the astrocytes (HP:0100707)1.71449300
140Astrocytoma (HP:0009592)1.71449300
141Congenital hepatic fibrosis (HP:0002612)1.71377656
142Action tremor (HP:0002345)1.70357998
143Hypoventilation (HP:0002791)1.70037414
144Narrow nasal bridge (HP:0000446)1.69797272
145Prominent nasal bridge (HP:0000426)1.69628426
146Cerebellar dysplasia (HP:0007033)1.69608242
147Incomplete penetrance (HP:0003829)1.69354326
148Neoplasm of the oral cavity (HP:0100649)1.69162587
149Abnormality of pain sensation (HP:0010832)1.68381926
150Impaired pain sensation (HP:0007328)1.68381926
151Urinary urgency (HP:0000012)1.68289937
152Focal dystonia (HP:0004373)1.68156650
153Dandy-Walker malformation (HP:0001305)1.67543988
154Inability to walk (HP:0002540)1.66209282
155Insidious onset (HP:0003587)1.66181181
156Termporal pattern (HP:0011008)1.66181181
157Genetic anticipation (HP:0003743)1.65116275
158Optic disc pallor (HP:0000543)1.63500937
159Esotropia (HP:0000565)1.63448016
160Mutism (HP:0002300)1.63361670
161Cutaneous syndactyly (HP:0012725)1.61219659
162Medial flaring of the eyebrow (HP:0010747)1.60852413
163Genital tract atresia (HP:0001827)1.60658186
164Torticollis (HP:0000473)1.59799890
165Abnormality of salivation (HP:0100755)1.59681585
166Tented upper lip vermilion (HP:0010804)1.59242811
167Left ventricular hypertrophy (HP:0001712)1.59164170
168Neoplasm of the peripheral nervous system (HP:0100007)1.58971506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.61333177
2EPHA43.85918935
3NTRK33.55752679
4FRK3.16413695
5MAP4K23.06749146
6MAP3K42.81091906
7MAP2K72.75996358
8MINK12.70057099
9CASK2.51815853
10MAP3K92.47163476
11MAPK132.26024527
12KSR12.19206195
13NTRK22.15042418
14TRIM282.08395939
15PNCK2.00274122
16SIK31.97350368
17DYRK21.88789564
18UHMK11.82586009
19PINK11.76680973
20WEE11.73753887
21ERBB31.71934827
22NUAK11.64769507
23BCR1.60016408
24OBSCN1.59296480
25MAP2K41.58967554
26PLK21.57626738
27SIK21.49570800
28CSNK1G11.44276569
29MAP3K121.37020584
30CSNK1A1L1.35878794
31DAPK21.34572850
32PAK61.31176291
33PHKG11.27832064
34PHKG21.27832064
35CDK51.25837971
36NME11.19682697
37DYRK31.19419884
38WNK31.19249640
39EPHA31.18860510
40PRPF4B1.16071601
41PRKD31.14636794
42BRSK21.13598724
43TNIK1.13481488
44LIMK11.13250180
45EPHB21.11144632
46GRK51.10951633
47PRKCG1.08440670
48CDK191.06420549
49ZAK1.05495217
50LATS11.05379461
51DAPK11.05000893
52ARAF1.03047118
53CDK181.02027232
54CAMK2A0.98380773
55DYRK1A0.97036616
56SGK2230.96642012
57SGK4940.96642012
58CDK140.95179940
59CDC70.93725192
60BMPR1B0.93695240
61RPS6KA40.92228959
62CSNK1G20.91753324
63CCNB10.91538275
64KSR20.90740187
65CDK150.89231084
66CAMK2B0.89163083
67STK38L0.88665526
68INSRR0.86220244
69LATS20.82783870
70PLK40.82456110
71SGK20.79215315
72CDK11A0.76801105
73NTRK10.76647441
74TAOK20.76103187
75PAK30.74631560
76GRK10.73184426
77CDK30.72930455
78CDC42BPA0.67246465
79DMPK0.66953843
80CSNK1G30.66257805
81RPS6KA20.66040051
82STK160.65603746
83BCKDK0.63542375
84ACVR1B0.63012731
85RIPK40.62657286
86MYLK0.61733496
87STK390.60944250
88ADRBK10.60063399
89TYRO30.59852464
90VRK10.57851447
91CAMKK20.56913896
92BMPR20.56001571
93PRKCE0.55101371
94BRAF0.54535294
95SRPK10.54514740
96ERBB20.54370802
97YES10.53664610
98PTK2B0.53520556
99OXSR10.53363860
100MAPK150.52642657
101LMTK20.52419260
102TAOK10.51784693
103TGFBR10.51536749
104PRKCZ0.51299316
105CAMK10.51255679
106ROCK10.51187803
107CAMKK10.51060817
108PLK30.50777393
109CSNK1A10.49998195
110AKT30.49842050
111SGK10.49456694
112WNK40.49316300
113CSNK1D0.49168982
114PLK10.48674534
115IRAK20.48554011
116ADRBK20.48296756
117BRSK10.47480895
118CAMK2D0.47308121
119CAMK1G0.47251677
120FGFR20.44627335
121ATM0.44380483
122ATR0.43115610
123CAMK40.41776342
124GRK70.40373632
125NEK10.40333366
126PKN10.40044730
127ROCK20.39964491
128MKNK20.39534133
129PRKG10.39485999
130STK110.37966326
131RAF10.37896470
132FLT30.37206940
133MARK20.36942662
134STK240.36767897
135RET0.36767392
136MKNK10.36531633
137PRKACA0.35509598
138RPS6KA50.35446933
139CSNK1E0.34542110

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.65672192
2Synaptic vesicle cycle_Homo sapiens_hsa047212.69234679
3Cardiac muscle contraction_Homo sapiens_hsa042602.65241299
4Parkinsons disease_Homo sapiens_hsa050122.51416023
5Oxidative phosphorylation_Homo sapiens_hsa001902.50364060
6Circadian entrainment_Homo sapiens_hsa047132.43392897
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42810223
8Dopaminergic synapse_Homo sapiens_hsa047282.34750100
9Amphetamine addiction_Homo sapiens_hsa050312.29923293
10Butanoate metabolism_Homo sapiens_hsa006502.28795296
11GABAergic synapse_Homo sapiens_hsa047272.23836300
12Olfactory transduction_Homo sapiens_hsa047402.23072735
13Long-term potentiation_Homo sapiens_hsa047202.21313765
14Glutamatergic synapse_Homo sapiens_hsa047242.17138799
15Morphine addiction_Homo sapiens_hsa050322.13476763
16Alzheimers disease_Homo sapiens_hsa050101.98990766
17Serotonergic synapse_Homo sapiens_hsa047261.85374117
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.84611302
19Cocaine addiction_Homo sapiens_hsa050301.84555566
20Steroid biosynthesis_Homo sapiens_hsa001001.82565834
21Huntingtons disease_Homo sapiens_hsa050161.79959034
22Axon guidance_Homo sapiens_hsa043601.78119590
23Cholinergic synapse_Homo sapiens_hsa047251.74961746
24Taste transduction_Homo sapiens_hsa047421.71574944
25Insulin secretion_Homo sapiens_hsa049111.71262495
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70802956
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.62904627
28Propanoate metabolism_Homo sapiens_hsa006401.61843800
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58003133
30Long-term depression_Homo sapiens_hsa047301.57129804
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56296801
32Gap junction_Homo sapiens_hsa045401.55699938
33Phototransduction_Homo sapiens_hsa047441.55044960
34Fanconi anemia pathway_Homo sapiens_hsa034601.54239209
35Oxytocin signaling pathway_Homo sapiens_hsa049211.53207636
36Salivary secretion_Homo sapiens_hsa049701.48815066
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46408570
38Calcium signaling pathway_Homo sapiens_hsa040201.45628014
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43992447
40Renin secretion_Homo sapiens_hsa049241.43755416
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41659193
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37626067
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37599546
44Collecting duct acid secretion_Homo sapiens_hsa049661.32898404
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30276559
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29529454
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29335152
48GnRH signaling pathway_Homo sapiens_hsa049121.26878940
49Protein export_Homo sapiens_hsa030601.23828939
50Oocyte meiosis_Homo sapiens_hsa041141.23602119
51Linoleic acid metabolism_Homo sapiens_hsa005911.22729492
52Dilated cardiomyopathy_Homo sapiens_hsa054141.22472920
53Melanogenesis_Homo sapiens_hsa049161.21039111
54Non-homologous end-joining_Homo sapiens_hsa034501.20127069
55Tryptophan metabolism_Homo sapiens_hsa003801.18428029
56Ether lipid metabolism_Homo sapiens_hsa005651.17356181
57Nitrogen metabolism_Homo sapiens_hsa009101.14757744
58Gastric acid secretion_Homo sapiens_hsa049711.14716020
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14085715
60Homologous recombination_Homo sapiens_hsa034401.13487863
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08770551
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08259402
63Basal transcription factors_Homo sapiens_hsa030221.03696442
64cAMP signaling pathway_Homo sapiens_hsa040241.00312295
65Fatty acid elongation_Homo sapiens_hsa000620.99703679
66Wnt signaling pathway_Homo sapiens_hsa043100.99496426
67ErbB signaling pathway_Homo sapiens_hsa040120.99132214
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97640118
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97309083
70Hedgehog signaling pathway_Homo sapiens_hsa043400.95836932
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94296270
72Vibrio cholerae infection_Homo sapiens_hsa051100.93531327
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92143880
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91491414
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91303302
76Estrogen signaling pathway_Homo sapiens_hsa049150.87676133
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86517691
78beta-Alanine metabolism_Homo sapiens_hsa004100.85931996
79Fatty acid metabolism_Homo sapiens_hsa012120.84775792
80Alcoholism_Homo sapiens_hsa050340.84664650
81Type II diabetes mellitus_Homo sapiens_hsa049300.83876252
82RNA degradation_Homo sapiens_hsa030180.80974438
83Glioma_Homo sapiens_hsa052140.80926521
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80213622
85Basal cell carcinoma_Homo sapiens_hsa052170.78039117
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.77784393
87Circadian rhythm_Homo sapiens_hsa047100.77020948
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76225692
89Endometrial cancer_Homo sapiens_hsa052130.75910794
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74348162
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71244090
92Hippo signaling pathway_Homo sapiens_hsa043900.68244756
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.67573636
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67018477
95Colorectal cancer_Homo sapiens_hsa052100.65463627
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63422988
97Lysine degradation_Homo sapiens_hsa003100.62907711
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.62516531
99Glucagon signaling pathway_Homo sapiens_hsa049220.61878789
100RNA polymerase_Homo sapiens_hsa030200.61791710
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.61405871
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60900940
103MAPK signaling pathway_Homo sapiens_hsa040100.59869531
104Peroxisome_Homo sapiens_hsa041460.59456424
105Choline metabolism in cancer_Homo sapiens_hsa052310.55633627
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55306935
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54542850
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54433663
109Retinol metabolism_Homo sapiens_hsa008300.53933335
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.52524174
111Chemical carcinogenesis_Homo sapiens_hsa052040.51392101
112Renal cell carcinoma_Homo sapiens_hsa052110.51242183
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50145715
114Insulin signaling pathway_Homo sapiens_hsa049100.48710326
115Ras signaling pathway_Homo sapiens_hsa040140.48634436
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48458184
117Fatty acid degradation_Homo sapiens_hsa000710.48173795
118Ovarian steroidogenesis_Homo sapiens_hsa049130.47289128
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47196738
120Rap1 signaling pathway_Homo sapiens_hsa040150.46731447
121Base excision repair_Homo sapiens_hsa034100.46317936
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45561785
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45271543
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.45267812
125ABC transporters_Homo sapiens_hsa020100.44908482
126Dorso-ventral axis formation_Homo sapiens_hsa043200.43724446
127Glycerolipid metabolism_Homo sapiens_hsa005610.43665799
128VEGF signaling pathway_Homo sapiens_hsa043700.43056024
129mRNA surveillance pathway_Homo sapiens_hsa030150.42052040
130Pancreatic secretion_Homo sapiens_hsa049720.41966117
131Tight junction_Homo sapiens_hsa045300.41822812
132TGF-beta signaling pathway_Homo sapiens_hsa043500.38490503
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37856659
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37469255
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36843743
136Thyroid hormone synthesis_Homo sapiens_hsa049180.34531796
137mTOR signaling pathway_Homo sapiens_hsa041500.30860811
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.30831756
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30205078
140Regulation of autophagy_Homo sapiens_hsa041400.27555248
141Non-small cell lung cancer_Homo sapiens_hsa052230.26315971
142FoxO signaling pathway_Homo sapiens_hsa040680.25998533
143Prion diseases_Homo sapiens_hsa050200.24466728
144Melanoma_Homo sapiens_hsa052180.23822856
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23166083

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