ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	locomotory exploration behavior (GO:0035641)	4.03794369
2	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.73504824
3	synaptic vesicle maturation (GO:0016188)	3.70513129
4	layer formation in cerebral cortex (GO:0021819)	3.59858550
5	plasma membrane repair (GO:0001778)	3.59546479
6	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.58258926
7	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.51564498
8	sodium ion export (GO:0071436)	3.37039979
9	establishment of nucleus localization (GO:0040023)	3.35482785
10	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.29526572
11	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.23614670
12	activation of protein kinase A activity (GO:0034199)	3.17596442
13	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.13759446
14	cell communication by electrical coupling (GO:0010644)	3.08348358
15	vocalization behavior (GO:0071625)	3.07330820
16	regulation of synapse structural plasticity (GO:0051823)	3.07138794
17	negative regulation of catenin import into nucleus (GO:0035414)	3.02726320
18	stress fiber assembly (GO:0043149)	2.98496533
19	activation of Rac GTPase activity (GO:0032863)	2.93131891
20	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.91786801
21	cellular potassium ion homeostasis (GO:0030007)	2.90571917
22	dendrite morphogenesis (GO:0048813)	2.82349689
23	cerebellar granule cell differentiation (GO:0021707)	2.81302800
24	regulation of NFAT protein import into nucleus (GO:0051532)	2.80250476
25	glutamate secretion (GO:0014047)	2.78525400
26	dendritic spine morphogenesis (GO:0060997)	2.77200437
27	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.74210116
28	skin morphogenesis (GO:0043589)	2.73307646
29	positive regulation of synapse maturation (GO:0090129)	2.72075210
30	neuromuscular process controlling balance (GO:0050885)	2.70856423
31	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.70825124
32	adherens junction assembly (GO:0034333)	2.70679394
33	desmosome organization (GO:0002934)	2.69881909
34	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.65844945
35	exploration behavior (GO:0035640)	2.65321896
36	barbed-end actin filament capping (GO:0051016)	2.63722171
37	regulation of early endosome to late endosome transport (GO:2000641)	2.60793481
38	cell communication involved in cardiac conduction (GO:0086065)	2.59969312
39	regulation of glutamate receptor signaling pathway (GO:1900449)	2.59325899
40	neuronal ion channel clustering (GO:0045161)	2.58951148
41	protein localization to endosome (GO:0036010)	2.58845674
42	negative regulation of organelle assembly (GO:1902116)	2.58016542
43	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	2.57743722
44	peripheral nervous system axon ensheathment (GO:0032292)	2.55476046
45	myelination in peripheral nervous system (GO:0022011)	2.55476046
46	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	2.54813982
47	regulation of dendritic spine morphogenesis (GO:0061001)	2.54473158
48	regulation of synaptic vesicle exocytosis (GO:2000300)	2.53094787
49	cell adhesion mediated by integrin (GO:0033627)	2.51579831
50	positive regulation of blood vessel endothelial cell migration (GO:0043536)	2.51572775
51	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.51537091
52	actin filament depolymerization (GO:0030042)	2.50862048
53	cortical actin cytoskeleton organization (GO:0030866)	2.50210146
54	regulation of clathrin-mediated endocytosis (GO:2000369)	2.50195038
55	regulation of glucose import in response to insulin stimulus (GO:2001273)	2.49891287
56	peptidyl-lysine dimethylation (GO:0018027)	2.48832409
57	vascular endothelial growth factor receptor signaling pathway (GO:0048010)	2.47609238
58	cellular sodium ion homeostasis (GO:0006883)	2.46782615
59	prepulse inhibition (GO:0060134)	2.46000389
60	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.43938286
61	proline transport (GO:0015824)	2.42662331
62	endothelial cell chemotaxis (GO:0035767)	2.42423324
63	regulation of ARF protein signal transduction (GO:0032012)	2.42258335
64	cerebellar Purkinje cell layer development (GO:0021680)	2.41468684
65	glial cell proliferation (GO:0014009)	2.41466227
66	protein targeting to plasma membrane (GO:0072661)	2.41410575
67	cell volume homeostasis (GO:0006884)	2.41362475
68	atrioventricular valve morphogenesis (GO:0003181)	2.41300716
69	amino acid import (GO:0043090)	2.40698043
70	neurotransmitter secretion (GO:0007269)	2.40374278
71	axon extension involved in axon guidance (GO:0048846)	2.40371207
72	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.40371207
73	cAMP biosynthetic process (GO:0006171)	2.40311315
74	regulation of long-term neuronal synaptic plasticity (GO:0048169)	2.39505032
75	epithelial cell-cell adhesion (GO:0090136)	2.39397264
76	cerebellar Purkinje cell differentiation (GO:0021702)	2.38122434
77	synaptic vesicle exocytosis (GO:0016079)	2.37945864
78	cell-substrate junction assembly (GO:0007044)	2.37925055
79	regulation of neuronal synaptic plasticity (GO:0048168)	2.37908050
80	potassium ion import (GO:0010107)	2.37514493
81	basement membrane organization (GO:0071711)	2.37203769
82	neuromuscular junction development (GO:0007528)	2.35684799
83	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.35635584
84	regulation of axon extension involved in axon guidance (GO:0048841)	2.35250623
85	cell-substrate adherens junction assembly (GO:0007045)	2.34957180
86	focal adhesion assembly (GO:0048041)	2.34957180
87	mating behavior (GO:0007617)	2.34568975
88	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.34447040
89	anatomical structure maturation (GO:0071695)	2.34196754
90	membrane depolarization during action potential (GO:0086010)	2.33962059
91	protein heterotrimerization (GO:0070208)	2.32699317
92	positive regulation of fibroblast migration (GO:0010763)	2.30882629
93	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.29388670
94	positive regulation of receptor recycling (GO:0001921)	2.28867480
95	negative regulation of fatty acid transport (GO:2000192)	2.28783724
96	protein retention in ER lumen (GO:0006621)	2.28743782
97	negative regulation of vascular permeability (GO:0043116)	2.27009806
98	positive regulation of axon extension (GO:0045773)	2.26389733
99	actin filament bundle organization (GO:0061572)	2.25792697
100	actin filament bundle assembly (GO:0051017)	2.25792697
101	myoblast fusion (GO:0007520)	2.25531925
102	positive regulation of myotube differentiation (GO:0010831)	2.24328835
103	cellular response to vascular endothelial growth factor stimulus (GO:0035924)	2.23712883
104	semaphorin-plexin signaling pathway (GO:0071526)	2.23525315
105	long-term memory (GO:0007616)	2.23525072
106	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	2.23039960
107	endodermal cell differentiation (GO:0035987)	2.22643840
108	extracellular matrix assembly (GO:0085029)	2.22487217
109	axonal fasciculation (GO:0007413)	2.22443219
110	hippo signaling (GO:0035329)	2.22193018
111	cell migration involved in heart development (GO:0060973)	2.21840060
112	signal complex assembly (GO:0007172)	2.21837252
113	negative regulation of cell size (GO:0045792)	2.21727798
114	vascular endothelial growth factor signaling pathway (GO:0038084)	2.21654563
115	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	2.21435249
116	cellular response to catecholamine stimulus (GO:0071870)	2.21402975
117	cellular response to monoamine stimulus (GO:0071868)	2.21402975
118	axon extension (GO:0048675)	2.20557985
119	syncytium formation by plasma membrane fusion (GO:0000768)	2.19808929
120	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.19670644
121	cortical cytoskeleton organization (GO:0030865)	2.19592782
122	neural tube development (GO:0021915)	2.19064475
123	hemidesmosome assembly (GO:0031581)	2.18507674
124	nucleus localization (GO:0051647)	2.18152715
125	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.16581175
126	negative regulation of anoikis (GO:2000811)	2.16372548
127	regulation of synaptic vesicle transport (GO:1902803)	2.14383000
128	vesicle transport along microtubule (GO:0047496)	2.14373014
129	paraxial mesoderm development (GO:0048339)	2.14345575
130	hypotonic response (GO:0006971)	2.14239427
131	cell migration in hindbrain (GO:0021535)	2.13518818
132	positive regulation of glycogen biosynthetic process (GO:0045725)	2.13420374
133	negative regulation of chondrocyte differentiation (GO:0032331)	2.13178554
134	dendritic spine organization (GO:0097061)	2.13139723
135	regulation of ARF GTPase activity (GO:0032312)	2.12526352
136	regulation of anoikis (GO:2000209)	2.11969762
137	glucocorticoid receptor signaling pathway (GO:0042921)	2.10811074
138	camera-type eye morphogenesis (GO:0048593)	2.10659237
139	protein localization to synapse (GO:0035418)	2.10464350
140	cell-cell junction maintenance (GO:0045217)	2.10339676
141	endothelial cell morphogenesis (GO:0001886)	2.10269254
142	gamma-aminobutyric acid transport (GO:0015812)	2.10092530
143	myotube differentiation (GO:0014902)	2.10015269
144	regulation of axon guidance (GO:1902667)	2.09499674
145	regulation of transforming growth factor beta2 production (GO:0032909)	2.09336588
146	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.09175191
147	membrane assembly (GO:0071709)	2.08283974
148	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.08116285
149	cell junction assembly (GO:0034329)	2.08086218
150	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.07807303
151	neuron recognition (GO:0008038)	2.07730804
152	synaptic transmission, glutamatergic (GO:0035249)	2.06360631
153	suckling behavior (GO:0001967)	2.05546108
154	cardiac myofibril assembly (GO:0055003)	2.05478422
155	adherens junction organization (GO:0034332)	2.05298810
156	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	2.04903719
157	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	2.04219165
158	negative regulation of sodium ion transport (GO:0010766)	2.03483874

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.78051175
2	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.46319309
3	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.30275321
4	DROSHA_22980978_ChIP-Seq_HELA_Human	2.27112556
5	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.16835101
6	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.16116298
7	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.13710976
8	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.13710976
9	ELK3_25401928_ChIP-Seq_HUVEC_Human	2.12211273
10	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.95300375
11	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.94769836
12	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.87087796
13	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.86500280
14	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.85381515
15	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.82931012
16	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.82329382
17	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.79969385
18	TCF7_22412390_ChIP-Seq_EML_Mouse	1.78896673
19	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.78784254
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.75829189
21	KDM2B_26808549_Chip-Seq_K562_Human	1.73600415
22	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.73202963
23	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.72909456
24	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.72255550
25	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.68534398
26	* TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.62785579
27	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.62661536
28	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.61902478
29	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.61901564
30	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.61181726
31	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.60268623
32	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.59063512
33	* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.57335280
34	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.56927564
35	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.55309262
36	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.53073580
37	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.52907933
38	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.52244502
39	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.51896750
40	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.48914149
41	* KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.48411149
42	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.48250287
43	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.47571282
44	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.47411915
45	* WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.47001301
46	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.44021290
47	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.43393256
48	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.43224657
49	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.40055203
50	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.39585967
51	MYC_22102868_ChIP-Seq_BL_Human	1.38393561
52	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.36704804
53	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.32123513
54	CLOCK_20551151_ChIP-Seq_293T_Human	1.31666292
55	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.30552529
56	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.30150250
57	KDM2B_26808549_Chip-Seq_DND41_Human	1.28912325
58	ZNF263_19887448_ChIP-Seq_K562_Human	1.27205617
59	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.27071587
60	ZNF274_21170338_ChIP-Seq_K562_Hela	1.26217561
61	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.24406581
62	REST_21632747_ChIP-Seq_MESCs_Mouse	1.23795576
63	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.23022140
64	TP53_22127205_ChIP-Seq_IMR90_Human	1.22799804
65	VDR_21846776_ChIP-Seq_THP-1_Human	1.20835048
66	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.20318221
67	AHR_22903824_ChIP-Seq_MCF-7_Human	1.18510696
68	* CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.18152509
69	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.17568327
70	SMC4_20622854_ChIP-Seq_HELA_Human	1.17375696
71	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.17078195
72	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.17006654
73	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.16790200
74	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.16790200
75	GBX2_23144817_ChIP-Seq_PC3_Human	1.16745197
76	* UBF1/2_26484160_Chip-Seq_HMECs_Human	1.16687618
77	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.15158543
78	LXR_22292898_ChIP-Seq_THP-1_Human	1.12248681
79	AR_19668381_ChIP-Seq_PC3_Human	1.12062394
80	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.10660229
81	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.10385321
82	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.10385321
83	* RING1B_27294783_Chip-Seq_NPCs_Mouse	1.10071012
84	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.09872831
85	* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.09207394
86	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.07886522
87	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.06646365
88	TP53_16413492_ChIP-PET_HCT116_Human	1.06627582
89	* ARNT_22903824_ChIP-Seq_MCF-7_Human	1.06507035
90	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.05033497
91	* P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.04925391
92	SMC1_22415368_ChIP-Seq_MEFs_Mouse	1.04662650
93	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.04197717
94	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.02757058
95	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00942101
96	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.00914093
97	* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.00291869
98	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.99752134
99	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.99705568
100	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.99666743
101	* RUNX1_27514584_Chip-Seq_MCF-7_Human	0.98803994
102	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	0.98679881
103	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.98415134
104	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.97944631
105	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.97942231
106	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.97875293
107	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.97165740
108	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.97056281
109	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.96267482
110	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.96188361
111	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.96004303
112	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.95685880
113	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.95648768
114	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.95565635
115	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.95361314
116	CTCF_27219007_Chip-Seq_Bcells_Human	0.93470373
117	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.93288767
118	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.92878262
119	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.92833304
120	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.92533656
121	CREB1_26743006_Chip-Seq_LNCaP_Human	0.92250191
122	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.91867770
123	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.91796882
124	* KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.91545511
125	KLF4_19829295_ChIP-Seq_ESCs_Human	0.91541381
126	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.91223327
127	SMAD4_21799915_ChIP-Seq_A2780_Human	0.89488205
128	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.89474872
129	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.88717254
130	* TP53_23651856_ChIP-Seq_MEFs_Mouse	0.88628077
131	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.88433486
132	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.88384002
133	RACK7_27058665_Chip-Seq_MCF-7_Human	0.88229458

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	4.23380324
2	MP0003705_abnormal_hypodermis_morpholog	3.32540135
3	MP0000013_abnormal_adipose_tissue	3.08788773
4	MP0005623_abnormal_meninges_morphology	3.05437662
5	MP0008438_abnormal_cutaneous_collagen	2.89005222
6	MP0005409_darkened_coat_color	2.59475229
7	MP0000751_myopathy	2.43513450
8	MP0005275_abnormal_skin_tensile	2.33365712
9	MP0009780_abnormal_chondrocyte_physiolo	2.30802428
10	MP0003635_abnormal_synaptic_transmissio	2.30129726
11	MP0004272_abnormal_basement_membrane	2.10828957
12	MP0010234_abnormal_vibrissa_follicle	1.88848095
13	MP0003283_abnormal_digestive_organ	1.82693362
14	MP0004270_analgesia	1.82517531
15	MP0001958_emphysema	1.80761019
16	MP0000003_abnormal_adipose_tissue	1.80362418
17	MP0005257_abnormal_intraocular_pressure	1.78906074
18	MP0004858_abnormal_nervous_system	1.74134983
19	MP0002063_abnormal_learning/memory/cond	1.74032114
20	MP0002909_abnormal_adrenal_gland	1.73296010
21	MP0005023_abnormal_wound_healing	1.66047127
22	MP0003045_fibrosis	1.63507864
23	MP0000537_abnormal_urethra_morphology	1.62751560
24	MP0005410_abnormal_fertilization	1.58880607
25	MP0000579_abnormal_nail_morphology	1.57593524
26	MP0004084_abnormal_cardiac_muscle	1.55961067
27	MP0002822_catalepsy	1.53583893
28	MP0002234_abnormal_pharynx_morphology	1.53346179
29	MP0008961_abnormal_basal_metabolism	1.51499405
30	MP0002060_abnormal_skin_morphology	1.49866619
31	MP0004233_abnormal_muscle_weight	1.49343806
32	MP0000569_abnormal_digit_pigmentation	1.49203393
33	MP0010368_abnormal_lymphatic_system	1.49038772
34	MP0009046_muscle_twitch	1.47672957
35	MP0000534_abnormal_ureter_morphology	1.46477473
36	MP0009745_abnormal_behavioral_response	1.43847299
37	MP0003091_abnormal_cell_migration	1.42290160
38	MP0003279_aneurysm	1.41612456
39	MP0004130_abnormal_muscle_cell	1.35939531
40	MP0000767_abnormal_smooth_muscle	1.35330411
41	MP0005503_abnormal_tendon_morphology	1.32379130
42	MP0003453_abnormal_keratinocyte_physiol	1.31767588
43	MP0001299_abnormal_eye_distance/	1.30207139
44	MP0005375_adipose_tissue_phenotype	1.29945066
45	MP0008569_lethality_at_weaning	1.28872449
46	MP0000762_abnormal_tongue_morphology	1.28841729
47	MP0003329_amyloid_beta_deposits	1.28341113
48	MP0004087_abnormal_muscle_fiber	1.25998109
49	MP0003566_abnormal_cell_adhesion	1.25331622
50	MP0004145_abnormal_muscle_electrophysio	1.23892780
51	MP0005167_abnormal_blood-brain_barrier	1.21810679
52	MP0003115_abnormal_respiratory_system	1.21762490
53	MP0003950_abnormal_plasma_membrane	1.20986801
54	MP0000733_abnormal_muscle_development	1.20786169
55	MP0002249_abnormal_larynx_morphology	1.20598947
56	MP0001879_abnormal_lymphatic_vessel	1.20243559
57	MP0002572_abnormal_emotion/affect_behav	1.18797932
58	MP0003879_abnormal_hair_cell	1.17866805
59	MP0002064_seizures	1.17530949
60	MP0006138_congestive_heart_failure	1.16280034
61	MP0004885_abnormal_endolymph	1.15792805
62	MP0001968_abnormal_touch/_nociception	1.11116511
63	MP0004036_abnormal_muscle_relaxation	1.10616882
64	MP0005187_abnormal_penis_morphology	1.08872126
65	MP0003385_abnormal_body_wall	1.08299210
66	MP0004811_abnormal_neuron_physiology	1.07366450
67	MP0001849_ear_inflammation	1.06980087
68	MP0000749_muscle_degeneration	1.05493002
69	MP0002877_abnormal_melanocyte_morpholog	1.02373633
70	MP0004215_abnormal_myocardial_fiber	1.02152197
71	MP0001177_atelectasis	1.02089441
72	MP0002896_abnormal_bone_mineralization	1.01864235
73	MP0003634_abnormal_glial_cell	1.01860714
74	MP0002837_dystrophic_cardiac_calcinosis	0.99606300
75	MP0005423_abnormal_somatic_nervous	0.98043309
76	MP0002734_abnormal_mechanical_nocicepti	0.96990551
77	MP0000747_muscle_weakness	0.96653752
78	MP0003690_abnormal_glial_cell	0.96309854
79	MP0004085_abnormal_heartbeat	0.94346104
80	MP0002272_abnormal_nervous_system	0.93645565
81	MP0005666_abnormal_adipose_tissue	0.93528990
82	MP0002108_abnormal_muscle_morphology	0.93282953
83	MP0003880_abnormal_central_pattern	0.93015444
84	MP0004185_abnormal_adipocyte_glucose	0.92838325
85	MP0001486_abnormal_startle_reflex	0.92753193
86	MP0005620_abnormal_muscle_contractility	0.92198877
87	MP0001440_abnormal_grooming_behavior	0.92180661
88	MP0002089_abnormal_postnatal_growth/wei	0.92039192
89	MP0004510_myositis	0.91821456
90	MP0005595_abnormal_vascular_smooth	0.90716212
91	MP0005076_abnormal_cell_differentiation	0.90353633
92	MP0009384_cardiac_valve_regurgitation	0.89307164
93	MP0003828_pulmonary_edema	0.88737103
94	MP0002184_abnormal_innervation	0.88211027
95	MP0000462_abnormal_digestive_system	0.87938439
96	MP0003300_gastrointestinal_ulcer	0.87369392
97	MP0005670_abnormal_white_adipose	0.86849230
98	MP0005508_abnormal_skeleton_morphology	0.85643259
99	MP0002796_impaired_skin_barrier	0.85563302
100	MP0000428_abnormal_craniofacial_morphol	0.84982277
101	MP0010630_abnormal_cardiac_muscle	0.84760064
102	MP0000955_abnormal_spinal_cord	0.84732223
103	MP0000467_abnormal_esophagus_morphology	0.84619109
104	MP0000759_abnormal_skeletal_muscle	0.84498644
105	MP0002133_abnormal_respiratory_system	0.83175322
106	MP0005388_respiratory_system_phenotype	0.83175322
107	MP0000778_abnormal_nervous_system	0.82450171
108	MP0003942_abnormal_urinary_system	0.82237502
109	MP0005621_abnormal_cell_physiology	0.80749065
110	MP0002925_abnormal_cardiovascular_devel	0.80729510
111	MP0005377_hearing/vestibular/ear_phenot	0.79353617
112	MP0003878_abnormal_ear_physiology	0.79353617
113	MP0003633_abnormal_nervous_system	0.78120096
114	MP0005330_cardiomyopathy	0.78055860
115	MP0002067_abnormal_sensory_capabilities	0.77929325
116	MP0002269_muscular_atrophy	0.76978255
117	MP0001915_intracranial_hemorrhage	0.76932065
118	MP0009053_abnormal_anal_canal	0.76903042
119	MP0001501_abnormal_sleep_pattern	0.76891848
120	MP0000750_abnormal_muscle_regeneration	0.76219660
121	MP0002972_abnormal_cardiac_muscle	0.75812527
122	MP0002152_abnormal_brain_morphology	0.74986905
123	MP0001348_abnormal_lacrimal_gland	0.74856577
124	MP0000920_abnormal_myelination	0.74397386
125	MP0010352_gastrointestinal_tract_polyps	0.73761026
126	MP0003935_abnormal_craniofacial_develop	0.73540046
127	MP0004484_altered_response_of	0.73154313
128	MP0010030_abnormal_orbit_morphology	0.72059810
129	MP0002295_abnormal_pulmonary_circulatio	0.71844093
130	MP0008775_abnormal_heart_ventricle	0.70853825
131	MP0005369_muscle_phenotype	0.70522717
132	MP0002882_abnormal_neuron_morphology	0.70073966
133	MP0002128_abnormal_blood_circulation	0.68523525
134	MP0001614_abnormal_blood_vessel	0.68497979
135	MP0002106_abnormal_muscle_physiology	0.66819307
136	MP0001502_abnormal_circadian_rhythm	0.65984570
137	MP0002114_abnormal_axial_skeleton	0.65755021

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Protrusio acetabuli (HP:0003179)	3.50318054
2	Cerebral aneurysm (HP:0004944)	3.45850607
3	Shallow orbits (HP:0000586)	3.39345097
4	Obstructive sleep apnea (HP:0002870)	3.29021567
5	Broad face (HP:0000283)	3.14768765
6	Broad metatarsal (HP:0001783)	3.05173547
7	Premature rupture of membranes (HP:0001788)	3.01462260
8	Bladder diverticulum (HP:0000015)	2.70458642
9	Action tremor (HP:0002345)	2.66176866
10	Abnormality of the lower motor neuron (HP:0002366)	2.65059391
11	Hyperacusis (HP:0010780)	2.64755494
12	Ulnar bowing (HP:0003031)	2.63182835
13	Ankle contracture (HP:0006466)	2.62983244
14	Myokymia (HP:0002411)	2.59249070
15	Aortic aneurysm (HP:0004942)	2.51401203
16	Increased variability in muscle fiber diameter (HP:0003557)	2.48431850
17	Upper limb amyotrophy (HP:0009129)	2.46433419
18	Distal upper limb amyotrophy (HP:0007149)	2.46433419
19	Dysmetric saccades (HP:0000641)	2.45463680
20	Atrophic scars (HP:0001075)	2.44873463
21	Wormian bones (HP:0002645)	2.42476823
22	Bowel diverticulosis (HP:0005222)	2.41065886
23	Buphthalmos (HP:0000557)	2.35122641
24	Difficulty running (HP:0009046)	2.34591058
25	Mitral valve prolapse (HP:0001634)	2.33710256
26	Focal seizures (HP:0007359)	2.33661246
27	Subacute progressive viral hepatitis (HP:0006572)	2.33642347
28	Increased connective tissue (HP:0009025)	2.33264221
29	Dilatation of the ascending aorta (HP:0005111)	2.31882154
30	Aortic dissection (HP:0002647)	2.30966308
31	Mitral regurgitation (HP:0001653)	2.30188767
32	Overgrowth (HP:0001548)	2.29368000
33	Bundle branch block (HP:0011710)	2.27830177
34	Elfin facies (HP:0004428)	2.26644836
35	Enlarged penis (HP:0000040)	2.22245905
36	Insomnia (HP:0100785)	2.22009737
37	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.20380604
38	Osteolytic defects of the hand bones (HP:0009699)	2.20380604
39	Difficulty climbing stairs (HP:0003551)	2.19736508
40	Pointed chin (HP:0000307)	2.19734007
41	Hemiplegia (HP:0002301)	2.19650118
42	Aneurysm (HP:0002617)	2.19494485
43	Hyporeflexia of lower limbs (HP:0002600)	2.18960310
44	Cerebral inclusion bodies (HP:0100314)	2.18651164
45	Neurofibrillary tangles (HP:0002185)	2.17945924
46	Renovascular hypertension (HP:0100817)	2.17632663
47	Lower limb amyotrophy (HP:0007210)	2.15820900
48	Mildly elevated creatine phosphokinase (HP:0008180)	2.13736270
49	Cervical subluxation (HP:0003308)	2.12430146
50	Long toe (HP:0010511)	2.10674984
51	Lymphangioma (HP:0100764)	2.08990952
52	Distal lower limb muscle weakness (HP:0009053)	2.08949986
53	Visual hallucinations (HP:0002367)	2.07080201
54	Bronchomalacia (HP:0002780)	2.05549903
55	Type 1 muscle fiber predominance (HP:0003803)	2.05445134
56	Macroorchidism (HP:0000053)	2.05344428
57	Abnormality of skeletal muscle fiber size (HP:0012084)	2.05189611
58	Focal motor seizures (HP:0011153)	2.02995686
59	Short nail (HP:0001799)	2.02220101
60	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.99001694
61	Scapular winging (HP:0003691)	1.97369283
62	Renal duplication (HP:0000075)	1.96110754
63	Disproportionate tall stature (HP:0001519)	1.94980191
64	Right ventricular cardiomyopathy (HP:0011663)	1.94821456
65	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.94505033
66	Supranuclear gaze palsy (HP:0000605)	1.93081856
67	Exercise-induced myalgia (HP:0003738)	1.92937557
68	Neonatal short-limb short stature (HP:0008921)	1.92101339
69	Resting tremor (HP:0002322)	1.91846336
70	Spinal rigidity (HP:0003306)	1.91813557
71	Fragile skin (HP:0001030)	1.90014843
72	Genu recurvatum (HP:0002816)	1.89564709
73	Flat cornea (HP:0007720)	1.88924477
74	Megalencephaly (HP:0001355)	1.88565385
75	Male infertility (HP:0003251)	1.88040229
76	Impaired social interactions (HP:0000735)	1.87722105
77	Abnormal social behavior (HP:0012433)	1.87722105
78	Ventricular fibrillation (HP:0001663)	1.87274730
79	Turricephaly (HP:0000262)	1.85454979
80	Hand muscle atrophy (HP:0009130)	1.84422965
81	Poor eye contact (HP:0000817)	1.84416134
82	Neoplasm of the heart (HP:0100544)	1.82751853
83	Overriding aorta (HP:0002623)	1.81942639
84	Deviation of the hallux (HP:0010051)	1.81940643
85	Ankyloglossia (HP:0010296)	1.81923624
86	Genetic anticipation (HP:0003743)	1.81315374
87	Milia (HP:0001056)	1.80566552
88	Dislocated radial head (HP:0003083)	1.80162096
89	Achilles tendon contracture (HP:0001771)	1.79931075
90	Progressive cerebellar ataxia (HP:0002073)	1.79598449
91	Joint laxity (HP:0001388)	1.79584674
92	Round ear (HP:0100830)	1.77949161
93	Hallux valgus (HP:0001822)	1.77343705
94	Sudden death (HP:0001699)	1.77067922
95	Hypoplasia of the iris (HP:0007676)	1.76948021
96	Vascular tortuosity (HP:0004948)	1.76403485
97	Thin ribs (HP:0000883)	1.75759295
98	Abnormality of the calcaneus (HP:0008364)	1.75581997
99	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.73941978
100	Annular pancreas (HP:0001734)	1.72839005
101	Striae distensae (HP:0001065)	1.72401386
102	Aortic regurgitation (HP:0001659)	1.72329350
103	Depression (HP:0000716)	1.71965509
104	Hamartoma of the eye (HP:0010568)	1.71527144
105	Spondylolisthesis (HP:0003302)	1.70699573
106	Blue sclerae (HP:0000592)	1.70613583
107	Termporal pattern (HP:0011008)	1.70490066
108	Insidious onset (HP:0003587)	1.70490066
109	Hypercortisolism (HP:0001578)	1.70142172
110	Hypoventilation (HP:0002791)	1.70064153
111	Aplasia of the phalanges of the hand (HP:0009802)	1.69363518
112	Aplasia involving bones of the extremities (HP:0009825)	1.69363518
113	Aplasia involving bones of the upper limbs (HP:0009823)	1.69363518
114	Advanced eruption of teeth (HP:0006288)	1.69192078
115	Arterial tortuosity (HP:0005116)	1.67629052
116	Distal lower limb amyotrophy (HP:0008944)	1.66934491
117	Vertebral compression fractures (HP:0002953)	1.66706392
118	Abnormality of the radial head (HP:0003995)	1.65843169
119	Hyperextensible skin (HP:0000974)	1.65347037
120	Wide anterior fontanel (HP:0000260)	1.65235220
121	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.64895702
122	Short 4th metacarpal (HP:0010044)	1.64895702
123	Thin bony cortex (HP:0002753)	1.64091963
124	Spinal cord lesions (HP:0100561)	1.63744603
125	Syringomyelia (HP:0003396)	1.63744603
126	Dysdiadochokinesis (HP:0002075)	1.63147931
127	Abnormality of oral frenula (HP:0000190)	1.62583628
128	Congenital glaucoma (HP:0001087)	1.61559038
129	Visceral angiomatosis (HP:0100761)	1.61551008
130	Vertebral arch anomaly (HP:0008438)	1.61206072
131	Impaired vibration sensation in the lower limbs (HP:0002166)	1.60574739
132	Abnormality of dentin (HP:0010299)	1.59872426
133	Bowed forearm bones (HP:0003956)	1.59635218
134	Bowing of the arm (HP:0006488)	1.59635218
135	Abnormality of the Achilles tendon (HP:0005109)	1.59475627
136	Asymmetry of the thorax (HP:0001555)	1.58749377
137	Natal tooth (HP:0000695)	1.58531569
138	Flat acetabular roof (HP:0003180)	1.58343990
139	Soft skin (HP:0000977)	1.56767995
140	Mild short stature (HP:0003502)	1.56315960
141	Spinal cord compression (HP:0002176)	1.56268915
142	Persistence of primary teeth (HP:0006335)	1.54699423
143	Arnold-Chiari malformation (HP:0002308)	1.52861714
144	Subaortic stenosis (HP:0001682)	1.52653062

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	3.91366180
2	PRKD3	3.37814184
3	RIPK1	2.92934881
4	PRPF4B	2.70467402
5	MST1R	2.68692640
6	CDK12	2.55563387
7	PKN2	2.38657955
8	NTRK3	2.25187254
9	TTN	2.22511124
10	PDGFRA	2.17487576
11	EPHA2	2.14318199
12	EPHA4	2.10861069
13	MAP3K9	2.05799949
14	MET	1.93380447
15	PAK6	1.91183989
16	CAMKK1	1.82871718
17	DDR2	1.76757955
18	STK38	1.75901980
19	SMG1	1.75146345
20	KSR2	1.70344102
21	TAOK1	1.64047271
22	PDK4	1.63506339
23	PDK3	1.63506339
24	DAPK2	1.61443952
25	ICK	1.60478400
26	TYRO3	1.60071904
27	DMPK	1.59653967
28	LATS2	1.57366331
29	LATS1	1.54187098
30	MAP3K13	1.49899426
31	NTRK1	1.45096893
32	PTK2B	1.43922698
33	EEF2K	1.43033541
34	LMTK2	1.42099370
35	PTK6	1.35378600
36	MARK1	1.34703874
37	MAP3K4	1.31897064
38	CAMK1G	1.31492039
39	MINK1	1.31069654
40	RET	1.29882645
41	FER	1.25247890
42	EPHB1	1.22052706
43	MAP3K2	1.17128643
44	PRKCH	1.16437133
45	FGFR4	1.14663935
46	PAK3	1.12082560
47	NTRK2	1.11351801
48	PTK2	1.10970359
49	TESK1	1.09785116
50	BMX	1.06935451
51	KSR1	1.05324168
52	PAK2	1.04648091
53	FGFR2	1.04238338
54	EPHB2	1.02714670
55	MOS	0.99890812
56	SIK1	0.98445191
57	PDGFRB	0.97732099
58	ARAF	0.92425591
59	MARK2	0.90580842
60	WNK1	0.90001537
61	CAMK1D	0.89045654
62	PHKG2	0.86928089
63	PHKG1	0.86928089
64	CDC42BPA	0.84744832
65	CDK5	0.84666399
66	SIK2	0.83946473
67	MYLK	0.83242613
68	TIE1	0.82834199
69	PDK2	0.82795217
70	STK11	0.82120127
71	SCYL2	0.81908260
72	SGK3	0.81807993
73	MAP3K10	0.81189351
74	ALK	0.80962951
75	CAMKK2	0.80133404
76	MAP2K4	0.79377952
77	NEK9	0.79096218
78	MAPK12	0.78895661
79	MTOR	0.78627094
80	PDPK1	0.78385000
81	MAP3K7	0.78148199
82	MAP3K6	0.77155239
83	IRAK3	0.75088667
84	TRPM7	0.73516614
85	PRKD2	0.71769246
86	ROCK1	0.71551974
87	UHMK1	0.69753246
88	PDK1	0.67668205
89	MELK	0.66666940
90	PRKD1	0.65686567
91	MAP2K1	0.61949282
92	FGFR1	0.60493229
93	CAMK1	0.60156472
94	CAMK2B	0.60049821
95	PAK4	0.59245884
96	MAPK11	0.57581833
97	WNK4	0.56512631
98	PINK1	0.55741939
99	MAPK7	0.55549074
100	MAPK10	0.54942218
101	LRRK2	0.53668876
102	ILK	0.52127726
103	CDK15	0.50342564
104	AKT3	0.50246121
105	HIPK2	0.50006765
106	RPS6KA2	0.49877793
107	SGK494	0.48392192
108	SGK223	0.48392192
109	MAP3K1	0.48247747
110	MAP2K3	0.48198276
111	RPS6KL1	0.48150308
112	RPS6KC1	0.48150308
113	FGFR3	0.47098552
114	SGK2	0.46950607
115	SGK1	0.46120404
116	ERN1	0.46102805
117	CDK14	0.44903544
118	CDK18	0.44541253
119	ROCK2	0.43126058
120	JAK1	0.41696612
121	NEK1	0.41194676
122	ERBB2	0.39688956
123	RPS6KA3	0.39680122
124	CAMK4	0.39048526
125	DYRK1B	0.38902321
126	CDK11A	0.38793764
127	SRC	0.38607798
128	CAMK2G	0.37924569
129	FRK	0.37535790
130	DAPK1	0.37242142
131	BRAF	0.36969372
132	BRD4	0.35441287
133	PRKG2	0.35311882
134	ERBB4	0.34645299
135	PRKCG	0.34372807

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.89518323
2	Long-term potentiation_Homo sapiens_hsa04720	1.79361987
3	Circadian entrainment_Homo sapiens_hsa04713	1.77590481
4	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.69378835
5	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.62362430
6	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.62357217
7	Gastric acid secretion_Homo sapiens_hsa04971	1.58911769
8	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.58068951
9	Salivary secretion_Homo sapiens_hsa04970	1.56740146
10	Amphetamine addiction_Homo sapiens_hsa05031	1.53855686
11	Olfactory transduction_Homo sapiens_hsa04740	1.53602261
12	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.50145800
13	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.49326552
14	Glutamatergic synapse_Homo sapiens_hsa04724	1.48494774
15	Renin secretion_Homo sapiens_hsa04924	1.46712407
16	Estrogen signaling pathway_Homo sapiens_hsa04915	1.45785147
17	Glioma_Homo sapiens_hsa05214	1.42590911
18	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.41369834
19	Insulin secretion_Homo sapiens_hsa04911	1.39921313
20	Nicotine addiction_Homo sapiens_hsa05033	1.39681231
21	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.39511520
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.36931305
23	Dopaminergic synapse_Homo sapiens_hsa04728	1.36913297
24	GABAergic synapse_Homo sapiens_hsa04727	1.36801627
25	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.36773988
26	Focal adhesion_Homo sapiens_hsa04510	1.36629303
27	Morphine addiction_Homo sapiens_hsa05032	1.34672239
28	Cholinergic synapse_Homo sapiens_hsa04725	1.33457970
29	GnRH signaling pathway_Homo sapiens_hsa04912	1.32007745
30	Gap junction_Homo sapiens_hsa04540	1.30706741
31	ECM-receptor interaction_Homo sapiens_hsa04512	1.30600958
32	Type II diabetes mellitus_Homo sapiens_hsa04930	1.28185602
33	Notch signaling pathway_Homo sapiens_hsa04330	1.28136741
34	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.27541784
35	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.27087636
36	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.26247911
37	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.25559043
38	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.20848175
39	Cocaine addiction_Homo sapiens_hsa05030	1.18709102
40	cAMP signaling pathway_Homo sapiens_hsa04024	1.17847545
41	Pancreatic cancer_Homo sapiens_hsa05212	1.17211099
42	Prion diseases_Homo sapiens_hsa05020	1.15569527
43	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.13928031
44	Axon guidance_Homo sapiens_hsa04360	1.13915761
45	Long-term depression_Homo sapiens_hsa04730	1.13294030
46	Melanogenesis_Homo sapiens_hsa04916	1.12676374
47	Proteoglycans in cancer_Homo sapiens_hsa05205	1.11081043
48	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.09922523
49	Endometrial cancer_Homo sapiens_hsa05213	1.08678871
50	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.07007372
51	VEGF signaling pathway_Homo sapiens_hsa04370	1.06328059
52	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.05695706
53	MicroRNAs in cancer_Homo sapiens_hsa05206	1.05057977
54	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.04688557
55	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.04540139
56	mTOR signaling pathway_Homo sapiens_hsa04150	1.03048015
57	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.02419813
58	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.01627376
59	Calcium signaling pathway_Homo sapiens_hsa04020	1.00411298
60	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.98599340
61	ErbB signaling pathway_Homo sapiens_hsa04012	0.97751839
62	Adherens junction_Homo sapiens_hsa04520	0.96641163
63	Glucagon signaling pathway_Homo sapiens_hsa04922	0.95860260
64	Taste transduction_Homo sapiens_hsa04742	0.95664409
65	Rap1 signaling pathway_Homo sapiens_hsa04015	0.95057259
66	Acute myeloid leukemia_Homo sapiens_hsa05221	0.94685104
67	Thyroid cancer_Homo sapiens_hsa05216	0.94088175
68	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.93653042
69	Amoebiasis_Homo sapiens_hsa05146	0.93431912
70	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.92987068
71	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.92403260
72	Tight junction_Homo sapiens_hsa04530	0.91667946
73	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.89347208
74	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.88438913
75	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.87896881
76	Hippo signaling pathway_Homo sapiens_hsa04390	0.86911024
77	Renal cell carcinoma_Homo sapiens_hsa05211	0.86125329
78	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.85963133
79	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.85095473
80	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.84069155
81	Non-small cell lung cancer_Homo sapiens_hsa05223	0.83704304
82	Insulin signaling pathway_Homo sapiens_hsa04910	0.81382972
83	Bile secretion_Homo sapiens_hsa04976	0.79734038
84	Protein digestion and absorption_Homo sapiens_hsa04974	0.79660782
85	Choline metabolism in cancer_Homo sapiens_hsa05231	0.79094238
86	Prostate cancer_Homo sapiens_hsa05215	0.78384283
87	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.78277740
88	Bladder cancer_Homo sapiens_hsa05219	0.78105938
89	Pathways in cancer_Homo sapiens_hsa05200	0.77152346
90	Pancreatic secretion_Homo sapiens_hsa04972	0.76341899
91	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.76066289
92	AMPK signaling pathway_Homo sapiens_hsa04152	0.75331643
93	Platelet activation_Homo sapiens_hsa04611	0.74337931
94	Insulin resistance_Homo sapiens_hsa04931	0.73954462
95	Lysine degradation_Homo sapiens_hsa00310	0.70020257
96	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.69562918
97	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.69543101
98	Oocyte meiosis_Homo sapiens_hsa04114	0.69465874
99	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.69444994
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.69156605
101	Prolactin signaling pathway_Homo sapiens_hsa04917	0.68156665
102	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.66254610
103	Small cell lung cancer_Homo sapiens_hsa05222	0.65380739
104	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.65035589
105	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.64973656
106	Endocytosis_Homo sapiens_hsa04144	0.64756045
107	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.64562691
108	Wnt signaling pathway_Homo sapiens_hsa04310	0.63112179
109	Basal cell carcinoma_Homo sapiens_hsa05217	0.62901251
110	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.62640409
111	Ras signaling pathway_Homo sapiens_hsa04014	0.59905045
112	Colorectal cancer_Homo sapiens_hsa05210	0.58061421
113	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.57986733
114	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57294980
115	Melanoma_Homo sapiens_hsa05218	0.56190840
116	Serotonergic synapse_Homo sapiens_hsa04726	0.52584034

MPRIP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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