ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	basic amino acid transport (GO:0015802)	8.81950917
2	regulation of glycogen (starch) synthase activity (GO:2000465)	6.38030456
3	response to histamine (GO:0034776)	5.41769325
4	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.84922582
5	dendritic spine morphogenesis (GO:0060997)	4.69793653
6	positive regulation of synapse maturation (GO:0090129)	4.55433606
7	pericardium development (GO:0060039)	4.28778809
8	negative regulation of phosphoprotein phosphatase activity (GO:0032515)	4.28287452
9	sarcoplasmic reticulum calcium ion transport (GO:0070296)	4.16730539
10	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	4.11739777
11	cell communication by electrical coupling (GO:0010644)	4.10701317
12	regulation of synapse maturation (GO:0090128)	4.09227719
13	negative regulation of Ras GTPase activity (GO:0034261)	4.03818027
14	regulation of cilium movement (GO:0003352)	3.89813678
15	protein K11-linked deubiquitination (GO:0035871)	3.85137716
16	spinal cord association neuron differentiation (GO:0021527)	3.83885666
17	peptidyl-lysine dimethylation (GO:0018027)	3.75690362
18	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	3.73792019
19	organ growth (GO:0035265)	3.72802754
20	positive regulation of glycogen metabolic process (GO:0070875)	3.66773303
21	vocalization behavior (GO:0071625)	3.65378144
22	single strand break repair (GO:0000012)	3.62127420
23	carnitine shuttle (GO:0006853)	3.52025283
24	positive regulation of glycogen biosynthetic process (GO:0045725)	3.50609236
25	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.49349012
26	protein polyglutamylation (GO:0018095)	3.42558026
27	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	3.35854157
28	amino acid transmembrane transport (GO:0003333)	3.35117446
29	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	3.34311159
30	negative regulation of catenin import into nucleus (GO:0035414)	3.33743508
31	cellular response to ammonium ion (GO:0071242)	3.33309457
32	behavioral response to nicotine (GO:0035095)	3.32123980
33	response to redox state (GO:0051775)	3.31747811
34	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.14971345
35	establishment of monopolar cell polarity (GO:0061162)	3.12737868
36	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.12737868
37	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.06607428
38	response to gravity (GO:0009629)	3.05544059
39	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	3.03614573
40	prenylation (GO:0097354)	3.03251681
41	protein prenylation (GO:0018342)	3.03251681
42	positive regulation of gastrulation (GO:2000543)	3.01060022
43	negative regulation of protein localization to cell surface (GO:2000009)	2.98339388
44	regulation of sequestering of triglyceride (GO:0010889)	2.98247097
45	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	2.95722808
46	cell migration in hindbrain (GO:0021535)	2.93727849
47	central nervous system projection neuron axonogenesis (GO:0021952)	2.93712507
48	regulation of glucokinase activity (GO:0033131)	2.89927450
49	regulation of hexokinase activity (GO:1903299)	2.89927450
50	neuronal action potential propagation (GO:0019227)	2.88516621
51	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.88134856
52	layer formation in cerebral cortex (GO:0021819)	2.86817613
53	cell communication involved in cardiac conduction (GO:0086065)	2.86383798
54	axonal fasciculation (GO:0007413)	2.84510459
55	cAMP catabolic process (GO:0006198)	2.84090458
56	negative regulation of heart rate (GO:0010459)	2.81278261
57	epithelial cilium movement (GO:0003351)	2.81269880
58	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.78830634
59	positive regulation of protein depolymerization (GO:1901881)	2.77959574
60	paraxial mesoderm development (GO:0048339)	2.77782685
61	lymphangiogenesis (GO:0001946)	2.76540540
62	activation of MAPKKK activity (GO:0000185)	2.73742877
63	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.73327897
64	fatty acid transmembrane transport (GO:1902001)	2.73231390
65	cyclic nucleotide catabolic process (GO:0009214)	2.71970486
66	regulation of G0 to G1 transition (GO:0070316)	2.71151464
67	cardiac myofibril assembly (GO:0055003)	2.69634835
68	regulation of toll-like receptor 4 signaling pathway (GO:0034143)	2.69074910
69	regulation of p38MAPK cascade (GO:1900744)	2.68498100
70	sarcomere organization (GO:0045214)	2.66843446
71	regulation of membrane repolarization (GO:0060306)	2.64473480
72	histone H3-K9 methylation (GO:0051567)	2.64061959
73	dendritic spine organization (GO:0097061)	2.62299255
74	urinary tract smooth muscle contraction (GO:0014848)	2.62151602
75	regulation of cell fate specification (GO:0042659)	2.61219044
76	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.59231939
77	mitochondrion transport along microtubule (GO:0047497)	2.59231939
78	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.56862683
79	folic acid metabolic process (GO:0046655)	2.56287849
80	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	2.53951942
81	intraspecies interaction between organisms (GO:0051703)	2.52755417
82	social behavior (GO:0035176)	2.52755417
83	regulation of microtubule-based movement (GO:0060632)	2.52520741
84	regulation of actin filament-based movement (GO:1903115)	2.51827598
85	skin morphogenesis (GO:0043589)	2.50936184
86	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.50495198
87	establishment of apical/basal cell polarity (GO:0035089)	2.50457163
88	regulation of cardiac muscle cell contraction (GO:0086004)	2.50118903
89	proteasome assembly (GO:0043248)	2.49325410
90	camera-type eye morphogenesis (GO:0048593)	2.47241967
91	amino-acid betaine transport (GO:0015838)	2.44853287
92	carnitine transport (GO:0015879)	2.44853287
93	embryonic foregut morphogenesis (GO:0048617)	2.44720259
94	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	2.44537060
95	negative regulation of insulin secretion (GO:0046676)	2.44180409
96	glomerulus development (GO:0032835)	2.43745211
97	post-anal tail morphogenesis (GO:0036342)	2.43342004
98	venous blood vessel morphogenesis (GO:0048845)	2.42821867
99	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.40934149
100	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.40354408

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.22687014
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.15503346
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.46088097
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.20430718
5	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.25772599
6	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.23419300
7	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.17814616
8	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.16589384
9	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.02857542
10	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.98220966
11	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.91899011
12	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.89897061
13	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.88887225
14	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.85409663
15	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.84629736
16	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.75672420
17	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.75620951
18	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.73098839
19	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.73098839
20	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.69026069
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67630615
22	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.66675046
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.66603710
24	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.66337842
25	VDR_22108803_ChIP-Seq_LS180_Human	1.64843609
26	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.63650005
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.63601655
28	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.62789623
29	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.60427370
30	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.58557843
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.54998792
32	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.53294938
33	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.51763998
34	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.49475393
35	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.44516639
36	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42604953
37	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.40477482
38	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.40133607
39	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.33829569
40	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.33316680
41	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.31436189
42	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.30557810
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.28538089
44	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.27574517
45	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.26661795
46	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.25623954
47	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.25590843
48	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.21618302
49	TP53_16413492_ChIP-PET_HCT116_Human	1.19503067
50	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.17348025
51	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.16571558
52	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.15813537
53	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.15198458
54	FUS_26573619_Chip-Seq_HEK293_Human	1.14356180
55	P300_19829295_ChIP-Seq_ESCs_Human	1.11751454
56	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.11329686
57	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.10494000
58	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.09753772
59	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.09724719
60	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.09673073
61	RXR_22108803_ChIP-Seq_LS180_Human	1.09428427
62	SMAD4_21799915_ChIP-Seq_A2780_Human	1.09065684
63	CTCF_27219007_Chip-Seq_Bcells_Human	1.08622494
64	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.06736605
65	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.06632577
66	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06539546
67	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.04560294
68	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.03508663
69	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.03122192
70	RNF2_27304074_Chip-Seq_NSC_Mouse	1.02206559
71	AR_19668381_ChIP-Seq_PC3_Human	1.00703677
72	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.99301596
73	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.98942570
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.98854611
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97443643
76	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.94839041
77	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.94607416
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.93772868
79	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.91776331
80	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.89319734
81	PRDM14_21183938_ChIP-Seq_MESCs_Mouse	0.87916129
82	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.85860661
83	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.85061992
84	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.84798909
85	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.84367519
86	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.82813521
87	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.82341248
88	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.79805264
89	TBL1_22424771_ChIP-Seq_293T_Human	0.79626725
90	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.78717331
91	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.78558872
92	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.78239518
93	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.78096085
94	STAT3_23295773_ChIP-Seq_U87_Human	0.77868736
95	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.77432511
96	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.77399522
97	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.77191294
98	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.77127849
99	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.75946014
100	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.74144578

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004885_abnormal_endolymph	3.29969492
2	MP0002163_abnormal_gland_morphology	3.07835568
3	MP0003122_maternal_imprinting	2.95952259
4	MP0008789_abnormal_olfactory_epithelium	2.81916686
5	MP0005499_abnormal_olfactory_system	2.70956727
6	MP0005394_taste/olfaction_phenotype	2.70956727
7	MP0000566_synostosis	2.62842767
8	MP0001299_abnormal_eye_distance/	2.52504260
9	MP0010386_abnormal_urinary_bladder	2.49125706
10	MP0000778_abnormal_nervous_system	2.48987819
11	MP0002638_abnormal_pupillary_reflex	2.44653547
12	MP0002089_abnormal_postnatal_growth/wei	2.43406034
13	MP0006054_spinal_hemorrhage	2.36602202
14	MP0002127_abnormal_cardiovascular_syste	2.34708434
15	MP0000751_myopathy	2.27962093
16	MP0002822_catalepsy	2.25948061
17	MP0009053_abnormal_anal_canal	2.16699586
18	MP0005423_abnormal_somatic_nervous	2.12611030
19	MP0003890_abnormal_embryonic-extraembry	2.00041265
20	MP0009250_abnormal_appendicular_skeleto	1.97978146
21	MP0003787_abnormal_imprinting	1.95593822
22	MP0001984_abnormal_olfaction	1.85542240
23	MP0003183_abnormal_peptide_metabolism	1.85186599
24	MP0006072_abnormal_retinal_apoptosis	1.83452249
25	MP0001502_abnormal_circadian_rhythm	1.82767067
26	MP0001879_abnormal_lymphatic_vessel	1.75781893
27	MP0003121_genomic_imprinting	1.72409426
28	MP0005409_darkened_coat_color	1.59404623
29	MP0000534_abnormal_ureter_morphology	1.54616213
30	MP0005670_abnormal_white_adipose	1.54229642
31	MP0001486_abnormal_startle_reflex	1.53239981
32	MP0002735_abnormal_chemical_nociception	1.51569990
33	MP0006276_abnormal_autonomic_nervous	1.49749657
34	MP0004133_heterotaxia	1.35581333
35	MP0002932_abnormal_joint_morphology	1.29921164
36	MP0003567_abnormal_fetal_cardiomyocyte	1.23281072
37	MP0005386_behavior/neurological_phenoty	1.21372152
38	MP0004924_abnormal_behavior	1.21372152
39	MP0005551_abnormal_eye_electrophysiolog	1.19937424
40	MP0004036_abnormal_muscle_relaxation	1.19531938
41	MP0002106_abnormal_muscle_physiology	1.19420838
42	MP0005379_endocrine/exocrine_gland_phen	1.19158543
43	MP0009384_cardiac_valve_regurgitation	1.18525838
44	MP0002837_dystrophic_cardiac_calcinosis	1.17971854
45	MP0002233_abnormal_nose_morphology	1.17414932
46	MP0002116_abnormal_craniofacial_bone	1.16271624
47	MP0000372_irregular_coat_pigmentation	1.11892975
48	MP0002752_abnormal_somatic_nervous	1.10088660
49	MP0005646_abnormal_pituitary_gland	1.08696171
50	MP0004145_abnormal_muscle_electrophysio	1.08091395
51	MP0002063_abnormal_learning/memory/cond	1.07007850
52	MP0010368_abnormal_lymphatic_system	1.05868420
53	MP0004215_abnormal_myocardial_fiber	1.05371138
54	MP0004510_myositis	1.04730752
55	MP0002108_abnormal_muscle_morphology	1.04446261
56	MP0005253_abnormal_eye_physiology	1.04156467
57	MP0001188_hyperpigmentation	1.02786971
58	MP0009780_abnormal_chondrocyte_physiolo	1.02709504
59	MP0002909_abnormal_adrenal_gland	1.02539887
60	MP0004130_abnormal_muscle_cell	1.02507022
61	MP0001440_abnormal_grooming_behavior	1.02008906
62	MP0005503_abnormal_tendon_morphology	1.00981605
63	MP0005369_muscle_phenotype	0.99263571
64	MP0002882_abnormal_neuron_morphology	0.98819941
65	MP0005248_abnormal_Harderian_gland	0.97705328
66	MP0003385_abnormal_body_wall	0.96783778
67	MP0001529_abnormal_vocalization	0.96157443
68	MP0010030_abnormal_orbit_morphology	0.95522879
69	MP0003941_abnormal_skin_development	0.93570272
70	MP0002972_abnormal_cardiac_muscle	0.91659638
71	MP0000749_muscle_degeneration	0.91481726
72	MP0000955_abnormal_spinal_cord	0.91327468
73	MP0005275_abnormal_skin_tensile	0.91118316
74	MP0005195_abnormal_posterior_eye	0.87596795
75	MP0000026_abnormal_inner_ear	0.87351573
76	MP0000428_abnormal_craniofacial_morphol	0.87224102
77	MP0004185_abnormal_adipocyte_glucose	0.86519322
78	MP0003755_abnormal_palate_morphology	0.84595671
79	MP0000579_abnormal_nail_morphology	0.84584586
80	MP0005620_abnormal_muscle_contractility	0.84095175
81	MP0004084_abnormal_cardiac_muscle	0.82779739
82	MP0002069_abnormal_eating/drinking_beha	0.82570173
83	MP0003221_abnormal_cardiomyocyte_apopto	0.79958647
84	MP0002114_abnormal_axial_skeleton	0.78681794
85	MP0000049_abnormal_middle_ear	0.78594051
86	MP0004087_abnormal_muscle_fiber	0.77484045
87	MP0001963_abnormal_hearing_physiology	0.76699694
88	MP0002184_abnormal_innervation	0.76544048
89	MP0010630_abnormal_cardiac_muscle	0.76287640
90	MP0002081_perinatal_lethality	0.75728301
91	MP0000003_abnormal_adipose_tissue	0.75594566
92	MP0009046_muscle_twitch	0.75518355
93	MP0003880_abnormal_central_pattern	0.75143207
94	MP0003861_abnormal_nervous_system	0.74572641
95	MP0003935_abnormal_craniofacial_develop	0.73396867
96	MP0010770_preweaning_lethality	0.71908198
97	MP0002082_postnatal_lethality	0.71908198
98	MP0003705_abnormal_hypodermis_morpholog	0.70976466
99	MP0005220_abnormal_exocrine_pancreas	0.70922976
100	MP0003635_abnormal_synaptic_transmissio	0.69980174

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Bell-shaped thorax (HP:0001591)	4.38172780
2	Absent eyebrow (HP:0002223)	4.20225879
3	Abnormality of the aortic arch (HP:0012303)	3.48438098
4	Stomach cancer (HP:0012126)	3.35475990
5	Short chin (HP:0000331)	3.35272901
6	Tented upper lip vermilion (HP:0010804)	2.99312309
7	Short tibia (HP:0005736)	2.97007467
8	Hypothermia (HP:0002045)	2.89097177
9	Hyperacusis (HP:0010780)	2.88810027
10	Hypoalphalipoproteinemia (HP:0003233)	2.80576116
11	Abnormality of the intervertebral disk (HP:0005108)	2.72773731
12	Diastasis recti (HP:0001540)	2.68650298
13	Muscle fiber splitting (HP:0003555)	2.64822943
14	2-3 toe syndactyly (HP:0004691)	2.63029878
15	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.60136786
16	Hypoplastic ischia (HP:0003175)	2.53936871
17	Syncope (HP:0001279)	2.52825517
18	Action tremor (HP:0002345)	2.52283684
19	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.49890508
20	Broad alveolar ridges (HP:0000187)	2.49173257
21	Concave nail (HP:0001598)	2.48164453
22	Wrist flexion contracture (HP:0001239)	2.43316946
23	Lymphangioma (HP:0100764)	2.38273055
24	Hyperlipoproteinemia (HP:0010980)	2.35676655
25	Hip contracture (HP:0003273)	2.33436163
26	Abnormality of the corticospinal tract (HP:0002492)	2.32694534
27	Subacute progressive viral hepatitis (HP:0006572)	2.29914320
28	Absent hair (HP:0002298)	2.28982229
29	Bulbous nose (HP:0000414)	2.26342553
30	Supranuclear gaze palsy (HP:0000605)	2.26118862
31	Abnormality of the ischium (HP:0003174)	2.25751534
32	Limb dystonia (HP:0002451)	2.24321035
33	Febrile seizures (HP:0002373)	2.22964283
34	Limited hip movement (HP:0008800)	2.21295810
35	Absent eyelashes (HP:0000561)	2.19879091
36	Bradycardia (HP:0001662)	2.14385279
37	Insidious onset (HP:0003587)	2.13953802
38	Termporal pattern (HP:0011008)	2.13953802
39	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.12399166
40	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.12399166
41	Abnormal respiratory motile cilium morphology (HP:0005938)	2.12104834
42	Abnormal respiratory epithelium morphology (HP:0012253)	2.12104834
43	Aplasia cutis congenita (HP:0001057)	2.08174348
44	Palpitations (HP:0001962)	2.07818744
45	Abnormality of the pubic bones (HP:0003172)	2.06915980
46	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.06697059
47	Fibular aplasia (HP:0002990)	2.06468553
48	Homocystinuria (HP:0002156)	2.05105495
49	Abnormality of homocysteine metabolism (HP:0010919)	2.05105495
50	Choroideremia (HP:0001139)	2.03408965
51	Intestinal atresia (HP:0011100)	2.02824867
52	Disproportionate short-trunk short stature (HP:0003521)	2.02093929
53	Abnormality of the odontoid process (HP:0003310)	2.01794892
54	Calf muscle hypertrophy (HP:0008981)	1.99157768
55	Progressive cerebellar ataxia (HP:0002073)	1.99146685
56	Abnormality of nail color (HP:0100643)	1.98758665
57	Abnormal pancreas size (HP:0012094)	1.96637142
58	Late onset (HP:0003584)	1.96345668
59	Exercise-induced muscle cramps (HP:0003710)	1.96277224
60	Nonprogressive disorder (HP:0003680)	1.96209952
61	Abnormality of the calf musculature (HP:0001430)	1.95883949
62	Spina bifida occulta (HP:0003298)	1.95448430
63	Abnormality of the pulmonary veins (HP:0011718)	1.95219253
64	Anomalous pulmonary venous return (HP:0010772)	1.94706591
65	Abnormality of the alveolar ridges (HP:0006477)	1.94444442
66	Polyphagia (HP:0002591)	1.93346482
67	Prolonged QT interval (HP:0001657)	1.92611403
68	Left ventricular hypertrophy (HP:0001712)	1.91321387
69	Hyporeflexia of lower limbs (HP:0002600)	1.91264803
70	Atrial fibrillation (HP:0005110)	1.89006716
71	Fibular hypoplasia (HP:0003038)	1.88238591
72	Nephrogenic diabetes insipidus (HP:0009806)	1.88000835
73	Type 1 muscle fiber predominance (HP:0003803)	1.85207192
74	Ulnar deviation of the wrist (HP:0003049)	1.85144835
75	Genetic anticipation (HP:0003743)	1.83359826
76	Hypoplastic left heart (HP:0004383)	1.81593914
77	Autoamputation (HP:0001218)	1.81295526
78	Turricephaly (HP:0000262)	1.80345238
79	Absent phalangeal crease (HP:0006109)	1.80171741
80	Abnormality of the right ventricle (HP:0001707)	1.79847628
81	Congenital sensorineural hearing impairment (HP:0008527)	1.79776151
82	Pseudobulbar signs (HP:0002200)	1.79214752
83	Muscle hypertrophy of the lower extremities (HP:0008968)	1.79147397
84	Right ventricular cardiomyopathy (HP:0011663)	1.76710386
85	Postural instability (HP:0002172)	1.76479064
86	Conical tooth (HP:0000698)	1.74831949
87	Anencephaly (HP:0002323)	1.73849019
88	Abnormal finger flexion creases (HP:0006143)	1.73494976
89	Ventricular arrhythmia (HP:0004308)	1.73236055
90	Neurofibrillary tangles (HP:0002185)	1.71183630
91	Vertebral arch anomaly (HP:0008438)	1.70835718
92	Steppage gait (HP:0003376)	1.68149904
93	Depressed nasal tip (HP:0000437)	1.67957499
94	Gait imbalance (HP:0002141)	1.67888517
95	Bundle branch block (HP:0011710)	1.67834909
96	Mesomelia (HP:0003027)	1.67230274
97	Hypoplasia of the odontoid process (HP:0003311)	1.66115813
98	Shawl scrotum (HP:0000049)	1.65386906
99	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.63776833
100	Intention tremor (HP:0002080)	1.63281890

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K12	9.43888162
2	RIPK1	4.90533137
3	MAP3K11	4.71951457
4	MAP4K2	4.33959902
5	MAP2K4	3.95606570
6	NTRK2	3.12425308
7	LMTK2	2.43151886
8	MAP3K5	2.15410532
9	MAP2K7	1.85329828
10	MAP3K10	1.77460221
11	TLK1	1.65932651
12	WNK3	1.65861611
13	MARK1	1.54459992
14	DYRK3	1.51881051
15	MARK3	1.50286429
16	MAP3K6	1.37263361
17	AKT3	1.36550885
18	MAP3K4	1.33685837
19	ACVR1B	1.33667760
20	CASK	1.32372589
21	PHKG2	1.30644026
22	PHKG1	1.30644026
23	OBSCN	1.26578534
24	PINK1	1.17787448
25	SGK2	0.93664141
26	KSR1	0.93104438
27	SGK223	0.92851972
28	SGK494	0.92851972
29	ICK	0.89132068
30	EPHB1	0.88972041
31	TTN	0.87337600
32	RPS6KA2	0.83765099
33	MAPK15	0.83489371
34	MAP3K1	0.79637721
35	PAK3	0.78950856
36	BLK	0.78220888
37	STK11	0.73671008
38	EPHB2	0.69909502
39	SGK3	0.69471712
40	PDK2	0.66888696
41	BMPR1B	0.66207440
42	LATS2	0.63461933
43	DYRK1B	0.60339492
44	PIM1	0.59882581
45	PIM2	0.57634902
46	PRKG1	0.55849921
47	MAP2K2	0.54073404
48	DYRK2	0.53773517
49	MAPK12	0.51470891
50	CDK8	0.50664213
51	EPHA2	0.48668556
52	MAP3K7	0.48667939
53	RET	0.45573828
54	PRKCI	0.44586053
55	MELK	0.43859544
56	RPS6KL1	0.42563293
57	RPS6KC1	0.42563293
58	DYRK1A	0.42300992
59	TGFBR1	0.41980950
60	HIPK2	0.39966351
61	BRAF	0.39379791
62	MAPK7	0.39339482
63	EIF2AK2	0.39318797
64	SGK1	0.38643732
65	NEK2	0.37802185
66	RPS6KA6	0.37069532
67	FGFR2	0.35204124
68	BCKDK	0.34836539
69	CAMK2A	0.33051122
70	MTOR	0.30928059
71	PRKAA1	0.30614344
72	MAPK4	0.30388736
73	STK38	0.30186872
74	TIE1	0.29954255
75	LATS1	0.26846384
76	FRK	0.24711383
77	CAMK1G	0.24020814
78	PIK3CA	0.23931919
79	CSNK1A1	0.23653052
80	RPS6KA4	0.22387016
81	FGFR4	0.21738739
82	CAMK1D	0.21702808
83	MYLK	0.21521847
84	CAMK2D	0.19561487
85	RPS6KA1	0.19464654
86	BMX	0.18325320
87	RPS6KB2	0.18200116
88	MAP3K14	0.16577112
89	MINK1	0.16425605
90	NTRK3	0.16329712
91	ZAK	0.15620777
92	PRKACA	0.13911006
93	MUSK	0.13770444
94	KIT	0.13747787
95	PNCK	0.13298928
96	VRK1	0.11769114
97	INSR	0.11645430
98	CSNK1A1L	0.11226862
99	PRKACG	0.11135692
100	DDR2	0.10708121

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	5.01773193
2	Circadian rhythm_Homo sapiens_hsa04710	2.82929228
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.58615152
4	Nicotine addiction_Homo sapiens_hsa05033	2.57640245
5	Dilated cardiomyopathy_Homo sapiens_hsa05414	2.16949043
6	Morphine addiction_Homo sapiens_hsa05032	2.16307038
7	Lysine degradation_Homo sapiens_hsa00310	2.16259581
8	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	2.08348950
9	Phenylalanine metabolism_Homo sapiens_hsa00360	1.92977978
10	Circadian entrainment_Homo sapiens_hsa04713	1.86757984
11	Renin secretion_Homo sapiens_hsa04924	1.80616184
12	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.75417283
13	Axon guidance_Homo sapiens_hsa04360	1.71561648
14	GABAergic synapse_Homo sapiens_hsa04727	1.57878372
15	Dopaminergic synapse_Homo sapiens_hsa04728	1.55805683
16	Sphingolipid metabolism_Homo sapiens_hsa00600	1.54555678
17	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.53328636
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.49745188
19	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.47993487
20	ECM-receptor interaction_Homo sapiens_hsa04512	1.31233134
21	Serotonergic synapse_Homo sapiens_hsa04726	1.30025040
22	Cocaine addiction_Homo sapiens_hsa05030	1.29896720
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.29287006
24	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.27155360
25	Amphetamine addiction_Homo sapiens_hsa05031	1.25128908
26	Cholinergic synapse_Homo sapiens_hsa04725	1.24778805
27	Notch signaling pathway_Homo sapiens_hsa04330	1.24564323
28	Tight junction_Homo sapiens_hsa04530	1.22085494
29	Gap junction_Homo sapiens_hsa04540	1.16834486
30	Insulin secretion_Homo sapiens_hsa04911	1.12972337
31	ErbB signaling pathway_Homo sapiens_hsa04012	1.12532453
32	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.11984452
33	AMPK signaling pathway_Homo sapiens_hsa04152	1.10909174
34	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.08602164
35	cAMP signaling pathway_Homo sapiens_hsa04024	1.05699578
36	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.02531825
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.98747170
38	GnRH signaling pathway_Homo sapiens_hsa04912	0.97491622
39	Phototransduction_Homo sapiens_hsa04744	0.96199037
40	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.95590425
41	Salivary secretion_Homo sapiens_hsa04970	0.94717815
42	Glucagon signaling pathway_Homo sapiens_hsa04922	0.93386172
43	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.91864141
44	Focal adhesion_Homo sapiens_hsa04510	0.91449393
45	Taste transduction_Homo sapiens_hsa04742	0.88077418
46	TNF signaling pathway_Homo sapiens_hsa04668	0.86396891
47	Long-term depression_Homo sapiens_hsa04730	0.85996100
48	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.85849556
49	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.84668509
50	Linoleic acid metabolism_Homo sapiens_hsa00591	0.84604952
51	Hippo signaling pathway_Homo sapiens_hsa04390	0.84219748
52	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.83899390
53	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.79549946
54	Bile secretion_Homo sapiens_hsa04976	0.79426075
55	Glutamatergic synapse_Homo sapiens_hsa04724	0.79027935
56	Renin-angiotensin system_Homo sapiens_hsa04614	0.78847610
57	ABC transporters_Homo sapiens_hsa02010	0.78153112
58	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.77276783
59	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.76118214
60	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.75706201
61	Non-homologous end-joining_Homo sapiens_hsa03450	0.74912005
62	Caffeine metabolism_Homo sapiens_hsa00232	0.74390385
63	One carbon pool by folate_Homo sapiens_hsa00670	0.74341966
64	Calcium signaling pathway_Homo sapiens_hsa04020	0.71931702
65	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.71281714
66	Tyrosine metabolism_Homo sapiens_hsa00350	0.71120400
67	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.70865180
68	Hepatitis B_Homo sapiens_hsa05161	0.69474482
69	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.66888734
70	MAPK signaling pathway_Homo sapiens_hsa04010	0.65103567
71	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.64214503
72	Olfactory transduction_Homo sapiens_hsa04740	0.62040954
73	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.61972939
74	mTOR signaling pathway_Homo sapiens_hsa04150	0.61424481
75	Wnt signaling pathway_Homo sapiens_hsa04310	0.61357695
76	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.59264004
77	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.58140530
78	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.57735168
79	mRNA surveillance pathway_Homo sapiens_hsa03015	0.57636610
80	FoxO signaling pathway_Homo sapiens_hsa04068	0.57604986
81	Gastric acid secretion_Homo sapiens_hsa04971	0.55809988
82	Hepatitis C_Homo sapiens_hsa05160	0.55717216
83	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.54986498
84	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.53868797
85	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.53846420
86	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.53182761
87	PPAR signaling pathway_Homo sapiens_hsa03320	0.52664432
88	Insulin resistance_Homo sapiens_hsa04931	0.50206290
89	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.49880414
90	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.49121429
91	Platelet activation_Homo sapiens_hsa04611	0.46651621
92	Insulin signaling pathway_Homo sapiens_hsa04910	0.46198987
93	Basal transcription factors_Homo sapiens_hsa03022	0.44138932
94	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.42737759
95	Colorectal cancer_Homo sapiens_hsa05210	0.41319992
96	Alcoholism_Homo sapiens_hsa05034	0.41299847
97	Histidine metabolism_Homo sapiens_hsa00340	0.40583382
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.37922570
99	Basal cell carcinoma_Homo sapiens_hsa05217	0.36251412
100	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.35802800

MPRIPP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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