ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maintenance of gastrointestinal epithelium (GO:0030277)	8.88170752
2	intestinal epithelial cell development (GO:0060576)	8.35403496
3	epithelial structure maintenance (GO:0010669)	7.10356130
4	O-glycan processing (GO:0016266)	6.89956220
5	lung secretory cell differentiation (GO:0061140)	6.80627270
6	sulfation (GO:0051923)	6.57062277
7	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.68498752
8	sulfate transmembrane transport (GO:1902358)	5.26446256
9	glandular epithelial cell differentiation (GO:0002067)	4.99247677
10	actin filament depolymerization (GO:0030042)	4.98799456
11	sulfur amino acid catabolic process (GO:0000098)	4.83850068
12	sialylation (GO:0097503)	4.62826401
13	sperm capacitation (GO:0048240)	4.60930417
14	nucleotide-sugar biosynthetic process (GO:0009226)	4.53661307
15	lipopolysaccharide biosynthetic process (GO:0009103)	4.53104626
16	bicarbonate transport (GO:0015701)	4.50753589
17	nucleotide-sugar metabolic process (GO:0009225)	4.42461395
18	protein O-linked glycosylation (GO:0006493)	4.41951697
19	amino sugar metabolic process (GO:0006040)	4.29102297
20	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	4.26814108
21	N-acetylglucosamine metabolic process (GO:0006044)	4.20451230
22	sulfate transport (GO:0008272)	4.10452092
23	glycosylceramide metabolic process (GO:0006677)	4.08499669
24	L-fucose catabolic process (GO:0042355)	4.08100691
25	fucose catabolic process (GO:0019317)	4.08100691
26	L-fucose metabolic process (GO:0042354)	4.08100691
27	glucosamine-containing compound metabolic process (GO:1901071)	4.01948339
28	regulation of cholesterol homeostasis (GO:2000188)	3.95115036
29	chloride transmembrane transport (GO:1902476)	3.88947186
30	positive regulation of actin filament depolymerization (GO:0030836)	3.85317633
31	lipopolysaccharide metabolic process (GO:0008653)	3.82406830
32	cGMP-mediated signaling (GO:0019934)	3.79073661
33	transcytosis (GO:0045056)	3.77615104
34	nucleoside diphosphate biosynthetic process (GO:0009133)	3.76556508
35	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.75628467
36	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.75628467
37	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.71416165
38	galactose catabolic process (GO:0019388)	3.70434217
39	keratan sulfate biosynthetic process (GO:0018146)	3.67510819
40	lung cell differentiation (GO:0060479)	3.65869475
41	oligosaccharide biosynthetic process (GO:0009312)	3.61256568
42	chloride transport (GO:0006821)	3.51521252
43	lung epithelial cell differentiation (GO:0060487)	3.50464400
44	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.46867498
45	regulation of pH (GO:0006885)	3.46820933
46	cell communication involved in cardiac conduction (GO:0086065)	3.42572195
47	inorganic anion transmembrane transport (GO:0098661)	3.42490075
48	membrane hyperpolarization (GO:0060081)	3.38346053
49	digestive system process (GO:0022600)	3.36159549
50	leukocyte tethering or rolling (GO:0050901)	3.32849157
51	protein autoprocessing (GO:0016540)	3.31633425
52	flavonoid metabolic process (GO:0009812)	3.28767571
53	branching involved in prostate gland morphogenesis (GO:0060442)	3.27250597
54	neuron fate determination (GO:0048664)	3.23581843
55	negative regulation of cell fate commitment (GO:0010454)	3.18297906
56	intestinal absorption (GO:0050892)	3.16183965
57	regulation of intracellular pH (GO:0051453)	3.15771044
58	positive regulation of epidermal cell differentiation (GO:0045606)	3.15381369
59	hypotonic response (GO:0006971)	3.12550102
60	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	3.12031604
61	regulation of respiratory burst (GO:0060263)	3.11990281
62	keratan sulfate metabolic process (GO:0042339)	3.11837548
63	ventricular cardiac muscle cell action potential (GO:0086005)	3.10867090
64	bile acid and bile salt transport (GO:0015721)	3.10561469
65	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.10424323
66	sodium ion export (GO:0071436)	3.08027017
67	renal system process involved in regulation of blood volume (GO:0001977)	3.04708418
68	N-acetylneuraminate metabolic process (GO:0006054)	3.03030581
69	sulfur compound transport (GO:0072348)	3.00877300
70	lipid translocation (GO:0034204)	2.99407307
71	phospholipid translocation (GO:0045332)	2.99407307
72	vitamin transmembrane transport (GO:0035461)	2.98465005
73	glycosphingolipid biosynthetic process (GO:0006688)	2.94718934
74	thrombin receptor signaling pathway (GO:0070493)	2.89406072
75	hemidesmosome assembly (GO:0031581)	2.89257547
76	homocysteine metabolic process (GO:0050667)	2.85758198
77	regulation of cellular pH (GO:0030641)	2.85208979
78	vocalization behavior (GO:0071625)	2.82375738
79	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.80847227
80	negative regulation of glycogen biosynthetic process (GO:0045719)	2.77992096
81	inorganic anion transport (GO:0015698)	2.77383125
82	fucose metabolic process (GO:0006004)	2.73764056
83	nucleotide transmembrane transport (GO:1901679)	2.73751313
84	cellular potassium ion homeostasis (GO:0030007)	2.73224910
85	desmosome organization (GO:0002934)	2.72202858
86	monovalent inorganic cation homeostasis (GO:0055067)	2.70997369
87	galactose metabolic process (GO:0006012)	2.70975174
88	columnar/cuboidal epithelial cell development (GO:0002066)	2.68132869
89	epithelial cell-cell adhesion (GO:0090136)	2.65981428
90	relaxation of cardiac muscle (GO:0055119)	2.64608097
91	neurotransmitter biosynthetic process (GO:0042136)	2.60734265
92	negative regulation of cholesterol transport (GO:0032375)	2.60251380
93	negative regulation of sterol transport (GO:0032372)	2.60251380
94	hepatocyte apoptotic process (GO:0097284)	2.59918002
95	N-glycan processing (GO:0006491)	2.57449759
96	anion transmembrane transport (GO:0098656)	2.56848563
97	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	2.56131787
98	phospholipid homeostasis (GO:0055091)	2.55711686
99	positive regulation of pseudopodium assembly (GO:0031274)	2.55006115
100	UDP-N-acetylglucosamine metabolic process (GO:0006047)	10.4956696

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	4.63993367
2	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.01552357
3	CDX2_20551321_ChIP-Seq_CACO-2_Human	3.70025469
4	SOX2_27498859_Chip-Seq_STOMACH_Mouse	3.30570226
5	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.70833563
6	SOX2_20726797_ChIP-Seq_SW620_Human	2.68945497
7	FOXO3_23340844_ChIP-Seq_DLD1_Human	2.55056319
8	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.48753923
9	GATA4_25053715_ChIP-Seq_YYC3_Human	2.42441626
10	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.41937332
11	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.24996444
12	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.10317367
13	GATA6_25053715_ChIP-Seq_YYC3_Human	2.09444901
14	DROSHA_22980978_ChIP-Seq_HELA_Human	2.03614811
15	BCAT_22108803_ChIP-Seq_LS180_Human	2.03046721
16	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.99283398
17	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.98556993
18	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.97834382
19	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.92110402
20	ZNF263_19887448_ChIP-Seq_K562_Human	1.91323833
21	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.84236211
22	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.78955811
23	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.78795177
24	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.77123567
25	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.76706674
26	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.73342423
27	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.67233195
28	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.65519615
29	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.65061602
30	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.63769250
31	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.61437789
32	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.61344107
33	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.53357875
34	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.50717901
35	RACK7_27058665_Chip-Seq_MCF-7_Human	1.50443570
36	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.46906755
37	GATA2_19941826_ChIP-Seq_K562_Human	1.44169037
38	KLF5_25053715_ChIP-Seq_YYC3_Human	1.43788669
39	CLOCK_20551151_ChIP-Seq_293T_Human	1.39708529
40	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.36883968
41	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.35694363
42	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.26916906
43	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.26758016
44	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.26410916
45	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.26132222
46	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.25801533
47	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.25090203
48	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.25090203
49	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.25090203
50	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.22704185
51	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.19002688
52	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.18854900
53	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.18764690
54	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.15486730
55	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.12964739
56	LXR_22292898_ChIP-Seq_THP-1_Human	1.12870214
57	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.12578643
58	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.12566373
59	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.08401013
60	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.08202187
61	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.08035374
62	CJUN_26792858_Chip-Seq_BT549_Human	1.07643273
63	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.07178998
64	CREB1_26743006_Chip-Seq_LNCaP_Human	1.06918519
65	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.05677358
66	VDR_22108803_ChIP-Seq_LS180_Human	1.05009554
67	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.04644638
68	ELF5_23300383_ChIP-Seq_T47D_Human	1.04277704
69	CDX2_22108803_ChIP-Seq_LS180_Human	1.02898040
70	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.02245308
71	HTT_18923047_ChIP-ChIP_STHdh_Human	1.01699024
72	GATA1_19941826_ChIP-Seq_K562_Human	1.01186518
73	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.00347686
74	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.00347686
75	AHR_22903824_ChIP-Seq_MCF-7_Human	0.98650740
76	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.98624477
77	ATF3_27146783_Chip-Seq_COLON_Human	0.96697736
78	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.93751325
79	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.93558711
80	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.93409204
81	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.91707421
82	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.91262272
83	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.90464794
84	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.89217613
85	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.88716652
86	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.88113324
87	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.86949598
88	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.84396633
89	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.84391106
90	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.83318731
91	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.82761765
92	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.82747495
93	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.82649006
94	AR_21909140_ChIP-Seq_LNCAP_Human	0.82426754
95	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.81988805
96	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.80271614
97	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.79970816
98	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.79118647
99	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.78933734
100	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.78926703

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	5.57611196
2	MP0003866_abnormal_defecation	5.51551279
3	MP0001663_abnormal_digestive_system	5.35993704
4	MP0005381_digestive/alimentary_phenotyp	4.64472534
5	MP0004043_abnormal_pH_regulation	4.26957026
6	MP0010155_abnormal_intestine_physiology	3.90677161
7	MP0006054_spinal_hemorrhage	3.43941061
8	MP0000490_abnormal_crypts_of	3.06304229
9	MP0004264_abnormal_extraembryonic_tissu	3.05855137
10	MP0000462_abnormal_digestive_system	2.98114024
11	MP0003705_abnormal_hypodermis_morpholog	2.91409351
12	MP0000477_abnormal_intestine_morphology	2.88651850
13	MP0000537_abnormal_urethra_morphology	2.72073202
14	MP0001873_stomach_inflammation	2.69339808
15	MP0005166_decreased_susceptibility_to	2.65443229
16	MP0010352_gastrointestinal_tract_polyps	2.62333840
17	MP0005085_abnormal_gallbladder_physiolo	2.51552431
18	MP0003283_abnormal_digestive_organ	2.48796062
19	MP0001666_abnormal_nutrient_absorption	2.46068909
20	MP0003868_abnormal_feces_composition	2.35043125
21	MP0000465_gastrointestinal_hemorrhage	2.23444315
22	MP0001664_abnormal_digestion	2.19143008
23	MP0009764_decreased_sensitivity_to	2.07127287
24	MP0000467_abnormal_esophagus_morphology	2.04344603
25	MP0005167_abnormal_blood-brain_barrier	2.01829268
26	MP0002277_abnormal_respiratory_mucosa	1.88165393
27	MP0002837_dystrophic_cardiac_calcinosis	1.87302518
28	MP0003300_gastrointestinal_ulcer	1.78450708
29	MP0008875_abnormal_xenobiotic_pharmacok	1.71807561
30	MP0005360_urolithiasis	1.65500117
31	MP0001765_abnormal_ion_homeostasis	1.64341601
32	MP0002822_catalepsy	1.57327262
33	MP0005365_abnormal_bile_salt	1.56157865
34	MP0005187_abnormal_penis_morphology	1.44942669
35	MP0005310_abnormal_salivary_gland	1.35091797
36	MP0003252_abnormal_bile_duct	1.33038038
37	MP0002139_abnormal_hepatobiliary_system	1.31343408
38	MP0010678_abnormal_skin_adnexa	1.26539579
39	MP0002909_abnormal_adrenal_gland	1.24652177
40	MP0000538_abnormal_urinary_bladder	1.24380764
41	MP0005165_increased_susceptibility_to	1.20016143
42	MP0010329_abnormal_lipoprotein_level	1.08487744
43	MP0002796_impaired_skin_barrier	1.05923156
44	MP0005636_abnormal_mineral_homeostasis	1.02912950
45	MP0004147_increased_porphyrin_level	1.01108225
46	MP0009643_abnormal_urine_homeostasis	0.95591210
47	MP0000470_abnormal_stomach_morphology	0.95068904
48	MP0001849_ear_inflammation	0.94855561
49	MP0003075_altered_response_to	0.94742054
50	MP0004484_altered_response_of	0.93458641
51	MP0008872_abnormal_physiological_respon	0.92766374
52	MP0003566_abnormal_cell_adhesion	0.92471863
53	MP0005257_abnormal_intraocular_pressure	0.91569704
54	MP0003091_abnormal_cell_migration	0.88688680
55	MP0000230_abnormal_systemic_arterial	0.86267273
56	MP0003453_abnormal_keratinocyte_physiol	0.81001537
57	MP0009379_abnormal_foot_pigmentation	0.78864618
58	MP0001845_abnormal_inflammatory_respons	0.74694236
59	MP0000013_abnormal_adipose_tissue	0.74455413
60	MP0004036_abnormal_muscle_relaxation	0.73194658
61	MP0002896_abnormal_bone_mineralization	0.70573159
62	MP0003303_peritoneal_inflammation	0.66598338
63	MP0003315_abnormal_perineum_morphology	0.66484860
64	MP0002060_abnormal_skin_morphology	0.65961167
65	MP0004270_analgesia	0.64805054
66	MP0003690_abnormal_glial_cell	0.64266091
67	MP0005319_abnormal_enzyme/_coenzyme	0.63283775
68	MP0002136_abnormal_kidney_physiology	0.62744621
69	MP0004185_abnormal_adipocyte_glucose	0.60909812
70	MP0000516_abnormal_urinary_system	0.60429868
71	MP0005367_renal/urinary_system_phenotyp	0.60429868
72	MP0002876_abnormal_thyroid_physiology	0.60142942
73	MP0003045_fibrosis	0.59396399
74	MP0004130_abnormal_muscle_cell	0.55931444
75	MP0001756_abnormal_urination	0.54677373
76	MP0010386_abnormal_urinary_bladder	0.54607110
77	MP0000613_abnormal_salivary_gland	0.54306962
78	MP0003329_amyloid_beta_deposits	0.53796342
79	MP0005501_abnormal_skin_physiology	0.53465473
80	MP0004859_abnormal_synaptic_plasticity	0.52552651
81	MP0004947_skin_inflammation	0.51397134
82	MP0000609_abnormal_liver_physiology	0.51390409
83	MP0000747_muscle_weakness	0.51287554
84	MP0002118_abnormal_lipid_homeostasis	0.51228436
85	MP0000003_abnormal_adipose_tissue	0.49868722
86	MP0003806_abnormal_nucleotide_metabolis	0.48452195
87	MP0009384_cardiac_valve_regurgitation	0.48140316
88	MP0002098_abnormal_vibrissa_morphology	0.46805235
89	MP0005377_hearing/vestibular/ear_phenot	0.46281349
90	MP0003878_abnormal_ear_physiology	0.46281349
91	MP0009780_abnormal_chondrocyte_physiolo	0.45118274
92	MP0001440_abnormal_grooming_behavior	0.44735651
93	MP0005025_abnormal_response_to	0.41665067
94	MP0008873_increased_physiological_sensi	0.41292218
95	MP0004084_abnormal_cardiac_muscle	0.40462930
96	MP0010771_integument_phenotype	0.40242178
97	MP0000604_amyloidosis	0.39790610
98	MP0001216_abnormal_epidermal_layer	0.39456525
99	MP0005330_cardiomyopathy	0.39236646
100	MP0002006_tumorigenesis	0.37173260

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperactive renin-angiotensin system (HP:0000841)	8.42189139
2	Metabolic alkalosis (HP:0200114)	7.31518964
3	Right ventricular cardiomyopathy (HP:0011663)	6.87779790
4	Ileus (HP:0002595)	6.59599081
5	Abnormality of chloride homeostasis (HP:0011422)	5.56773141
6	Abnormality of renin-angiotensin system (HP:0000847)	5.12310217
7	Abdominal distention (HP:0003270)	4.61364807
8	Abnormal tarsal ossification (HP:0008369)	4.28795882
9	Abnormality of the 1st metacarpal (HP:0010009)	4.24832262
10	Hyperaldosteronism (HP:0000859)	4.09218973
11	Gastrointestinal dysmotility (HP:0002579)	4.00982031
12	Flat acetabular roof (HP:0003180)	4.00394520
13	Malnutrition (HP:0004395)	3.96319590
14	Mildly elevated creatine phosphokinase (HP:0008180)	3.91234241
15	Short 1st metacarpal (HP:0010034)	3.66058008
16	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	3.66058008
17	Alkalosis (HP:0001948)	3.57072087
18	Abnormal foot bone ossification (HP:0010675)	3.47712068
19	Aortic aneurysm (HP:0004942)	3.44658234
20	Decreased circulating renin level (HP:0003351)	3.35540376
21	Limb-girdle muscle atrophy (HP:0003797)	3.35175104
22	Hyponatremia (HP:0002902)	2.94640257
23	Hypokalemia (HP:0002900)	2.92390045
24	Intrahepatic cholestasis (HP:0001406)	2.92359336
25	Abnormality of the distal phalanx of the thumb (HP:0009617)	2.91931416
26	Palpitations (HP:0001962)	2.88248751
27	Short phalanx of the thumb (HP:0009660)	2.87981723
28	Abnormality of carpal bone ossification (HP:0006257)	2.86900882
29	Abnormality of the 2nd finger (HP:0004100)	2.81968526
30	Rectal prolapse (HP:0002035)	2.76363919
31	Ureteral stenosis (HP:0000071)	2.73134011
32	Aortic dissection (HP:0002647)	2.68022033
33	Conjugated hyperbilirubinemia (HP:0002908)	2.62233636
34	Abnormal cartilage morphology (HP:0002763)	2.59968438
35	Short hallux (HP:0010109)	2.57031898
36	Ventricular fibrillation (HP:0001663)	2.56109052
37	Ureteral obstruction (HP:0006000)	2.48999623
38	Abnormality of potassium homeostasis (HP:0011042)	2.45951687
39	Abnormality of sodium homeostasis (HP:0010931)	2.42489947
40	Petechiae (HP:0000967)	2.40480397
41	Flattened epiphyses (HP:0003071)	2.39773857
42	Abnormal ossification of hand bones (HP:0005921)	2.37086973
43	Septate vagina (HP:0001153)	2.34711685
44	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.33390556
45	Adrenal overactivity (HP:0002717)	2.32039103
46	Spontaneous abortion (HP:0005268)	2.30520165
47	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.30503406
48	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	2.28704257
49	Neonatal short-limb short stature (HP:0008921)	2.28567513
50	Dehydration (HP:0001944)	2.24705621
51	Hoarse voice (HP:0001609)	2.23550730
52	Spinal cord compression (HP:0002176)	2.20333309
53	Syncope (HP:0001279)	2.19876682
54	Ventricular tachycardia (HP:0004756)	2.18972882
55	Vertebral hypoplasia (HP:0008417)	2.18191271
56	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	2.18191271
57	Neoplasm of the heart (HP:0100544)	2.16911704
58	Hyperparathyroidism (HP:0000843)	2.16717513
59	Abnormal vertebral ossification (HP:0100569)	2.16318603
60	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.15074753
61	Protuberant abdomen (HP:0001538)	2.13992786
62	Pustule (HP:0200039)	2.12847026
63	Micronodular cirrhosis (HP:0001413)	2.12721610
64	Abnormal hand bone ossification (HP:0010660)	2.07658463
65	Rimmed vacuoles (HP:0003805)	2.06562241
66	Woolly hair (HP:0002224)	2.05217170
67	Neck muscle weakness (HP:0000467)	2.05115489
68	Progressive sensorineural hearing impairment (HP:0000408)	2.03641231
69	Ankyloglossia (HP:0010296)	2.02951114
70	Vertebral clefting (HP:0008428)	2.00979414
71	Biliary tract neoplasm (HP:0100574)	1.99553767
72	Abnormal biliary tract morphology (HP:0012440)	1.98079796
73	Hyporeflexia of lower limbs (HP:0002600)	1.93620890
74	Broad metatarsal (HP:0001783)	1.92528231
75	Microretrognathia (HP:0000308)	1.89607710
76	Ventricular arrhythmia (HP:0004308)	1.89183733
77	Vascular calcification (HP:0004934)	1.85844824
78	Long toe (HP:0010511)	1.84373170
79	Abnormality of oral frenula (HP:0000190)	1.82686313
80	Short middle phalanx of finger (HP:0005819)	1.81902832
81	Deviation of the thumb (HP:0009603)	1.76033192
82	Atrophic scars (HP:0001075)	1.76023350
83	Late onset (HP:0003584)	1.75424554
84	Abnormality of the gastric mucosa (HP:0004295)	1.75215403
85	Cardiovascular calcification (HP:0011915)	1.74330970
86	Pili torti (HP:0003777)	1.73767556
87	Villous atrophy (HP:0011473)	1.72810982
88	Abnormality of small intestinal villus morphology (HP:0011472)	1.72810982
89	Ulnar deviation of finger (HP:0009465)	1.69706427
90	Proximal placement of thumb (HP:0009623)	1.69671129
91	Goiter (HP:0000853)	1.68363574
92	Visceral angiomatosis (HP:0100761)	1.67795144
93	Milia (HP:0001056)	1.66412071
94	Neoplasm of the rectum (HP:0100743)	1.62302777
95	Periodontitis (HP:0000704)	1.60792905
96	Fragile skin (HP:0001030)	1.60436007
97	Chronic diarrhea (HP:0002028)	1.60294822
98	Myopathic facies (HP:0002058)	1.58165953
99	Spastic diplegia (HP:0001264)	1.57558787
100	Ulnar bowing (HP:0003031)	1.57205732

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LMTK2	5.95674057
2	MST4	4.59212511
3	MST1R	4.30648293
4	MYLK	4.11835639
5	TESK1	3.34387946
6	PIK3CA	2.97156028
7	FRK	2.35104180
8	KSR2	2.27711574
9	LIMK1	2.22650168
10	PRKG2	2.17679596
11	RIPK1	2.11846479
12	DMPK	2.05785283
13	MAP3K2	1.93394090
14	EPHB2	1.86170714
15	PTK6	1.83135757
16	MAP3K9	1.78187267
17	MAP2K2	1.77119591
18	MET	1.70497424
19	TTN	1.69163757
20	RIPK4	1.52993273
21	MAP3K10	1.37627860
22	PKN2	1.36637106
23	STK10	1.34328230
24	MAP2K1	1.33590598
25	LRRK2	1.29397764
26	PIK3CG	1.28995147
27	DDR2	1.28428115
28	PAK2	1.25697117
29	ERN1	1.21820492
30	FER	1.20602544
31	PAK3	1.17360126
32	EPHB1	1.13124247
33	NME1	1.11539441
34	TRIB3	1.08313839
35	PAK4	1.04831755
36	WNK4	1.04760094
37	MAP3K13	0.99540416
38	PTK2	0.96651431
39	GRK6	0.91975873
40	ARAF	0.90757006
41	MAP3K7	0.90392885
42	ROCK1	0.88138938
43	EEF2K	0.82114018
44	CAMK2D	0.79996512
45	CAMKK1	0.79237874
46	MAP3K1	0.77529409
47	DAPK3	0.77293077
48	PRKAA2	0.76260242
49	MATK	0.74160630
50	SCYL2	0.71939406
51	ROCK2	0.71671958
52	MAP3K8	0.71132358
53	BMX	0.67997543
54	MAP3K12	0.67384193
55	ALK	0.67299242
56	STK39	0.65205271
57	PRKAA1	0.63378096
58	PRKCI	0.62315350
59	ERBB2	0.61297783
60	CDC42BPA	0.59956558
61	CAMK2G	0.58623289
62	TAOK1	0.58465050
63	PAK1	0.54616947
64	CAMK2B	0.52732483
65	FYN	0.51810984
66	ICK	0.49895470
67	PDPK1	0.49669315
68	MAPKAPK3	0.49424426
69	NEK1	0.48987578
70	KSR1	0.48524169
71	PDGFRA	0.48358133
72	RPS6KB2	0.44279654
73	MAPK11	0.43526389
74	PDK1	0.42872139
75	SRC	0.40908518
76	NTRK1	0.40008778
77	CSK	0.39424564
78	GSK3A	0.38895026
79	RAF1	0.37685339
80	PDK3	0.37530614
81	PDK4	0.37530614
82	PRKACG	0.36555098
83	CDK6	0.34617021
84	OXSR1	0.32888907
85	RET	0.30759412
86	PTK2B	0.30539187
87	PRKCA	0.29630557
88	CAMK2A	0.29136976
89	TYK2	0.28831749
90	CDK5	0.28052283
91	MAPKAPK2	0.27936591
92	PAK6	0.25272727
93	EPHA4	0.24911125
94	MINK1	0.24880661
95	PRKD1	0.23877972
96	DAPK2	0.23727817
97	LATS1	0.22916230
98	WNK1	0.21952834
99	PHKG2	0.21199780
100	PHKG1	0.21199780

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	5.36720665
2	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	4.63025904
3	Sulfur metabolism_Homo sapiens_hsa00920	4.56859127
4	Mineral absorption_Homo sapiens_hsa04978	3.71057869
5	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	3.67298441
6	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	3.62547414
7	Pancreatic secretion_Homo sapiens_hsa04972	2.80973063
8	Renin secretion_Homo sapiens_hsa04924	2.48536996
9	Bile secretion_Homo sapiens_hsa04976	2.39049477
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.34125955
11	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.15140151
12	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.97244692
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.53580598
14	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.40996578
15	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.37697875
16	Butanoate metabolism_Homo sapiens_hsa00650	1.33385207
17	Vibrio cholerae infection_Homo sapiens_hsa05110	1.28548030
18	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.23089163
19	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.12842111
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.11164450
21	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.08686042
22	Tight junction_Homo sapiens_hsa04530	1.05486187
23	Fatty acid degradation_Homo sapiens_hsa00071	0.98107961
24	Fat digestion and absorption_Homo sapiens_hsa04975	0.97339319
25	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.97246648
26	Salivary secretion_Homo sapiens_hsa04970	0.95112313
27	Histidine metabolism_Homo sapiens_hsa00340	0.95096031
28	Gastric acid secretion_Homo sapiens_hsa04971	0.93720145
29	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.92785348
30	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.92458937
31	Protein digestion and absorption_Homo sapiens_hsa04974	0.83348324
32	Tryptophan metabolism_Homo sapiens_hsa00380	0.82437911
33	Renin-angiotensin system_Homo sapiens_hsa04614	0.81509956
34	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.81430142
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.80404198
36	Propanoate metabolism_Homo sapiens_hsa00640	0.79432592
37	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.78978339
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.78386320
39	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.66715913
40	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66580105
41	Carbon metabolism_Homo sapiens_hsa01200	0.64754624
42	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.64737607
43	Thyroid cancer_Homo sapiens_hsa05216	0.63948955
44	Amoebiasis_Homo sapiens_hsa05146	0.63736306
45	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.61380755
46	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.60813686
47	Salmonella infection_Homo sapiens_hsa05132	0.59989924
48	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.57604717
49	Caffeine metabolism_Homo sapiens_hsa00232	0.56715137
50	PPAR signaling pathway_Homo sapiens_hsa03320	0.56262453
51	Fatty acid metabolism_Homo sapiens_hsa01212	0.54848515
52	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.54746121
53	Galactose metabolism_Homo sapiens_hsa00052	0.53589595
54	Adherens junction_Homo sapiens_hsa04520	0.51991158
55	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.51953157
56	Insulin secretion_Homo sapiens_hsa04911	0.47765948
57	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.46439406
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.45993728
59	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.45600766
60	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.45434654
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.42411385
62	Bladder cancer_Homo sapiens_hsa05219	0.42319668
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41029613
64	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.40658410
65	Arginine biosynthesis_Homo sapiens_hsa00220	0.40059470
66	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.39591425
67	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.38815547
68	Insulin resistance_Homo sapiens_hsa04931	0.38759098
69	Linoleic acid metabolism_Homo sapiens_hsa00591	0.38243150
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.37716715
71	Cardiac muscle contraction_Homo sapiens_hsa04260	0.35925431
72	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.35143570
73	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.35055429
74	Phenylalanine metabolism_Homo sapiens_hsa00360	0.34796453
75	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.32262707
76	Cocaine addiction_Homo sapiens_hsa05030	0.31413721
77	GnRH signaling pathway_Homo sapiens_hsa04912	0.30816918
78	Focal adhesion_Homo sapiens_hsa04510	0.30331867
79	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.29710640
80	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.29587175
81	Estrogen signaling pathway_Homo sapiens_hsa04915	0.28214699
82	Long-term potentiation_Homo sapiens_hsa04720	0.28180291
83	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.28041428
84	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.27799671
85	Glutathione metabolism_Homo sapiens_hsa00480	0.27114851
86	Folate biosynthesis_Homo sapiens_hsa00790	0.26960504
87	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.26902082
88	Platelet activation_Homo sapiens_hsa04611	0.26857728
89	VEGF signaling pathway_Homo sapiens_hsa04370	0.24993296
90	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.24553065
91	Cholinergic synapse_Homo sapiens_hsa04725	0.24374608
92	Long-term depression_Homo sapiens_hsa04730	0.23868080
93	Amphetamine addiction_Homo sapiens_hsa05031	0.23090790
94	Hepatitis C_Homo sapiens_hsa05160	0.22938468
95	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.22863047
96	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.22308426
97	Gap junction_Homo sapiens_hsa04540	0.19696951
98	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.18585775
99	Proteoglycans in cancer_Homo sapiens_hsa05205	0.17896195
100	ABC transporters_Homo sapiens_hsa02010	0.16834419

MPTX1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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