MPV17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial inner membrane protein that is implicated in the metabolism of reactive oxygen species. Mutations in this gene have been associated with the hepatocerebral form of mitochondrial DNA depletion syndrome (MDDS). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)4.64548632
2doxorubicin metabolic process (GO:0044598)4.64548632
3daunorubicin metabolic process (GO:0044597)4.64548632
4protein complex biogenesis (GO:0070271)4.58338007
5respiratory chain complex IV assembly (GO:0008535)4.25826062
6cytochrome complex assembly (GO:0017004)4.25265044
7chaperone-mediated protein transport (GO:0072321)4.18305953
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.16978783
9mitochondrial respiratory chain complex I assembly (GO:0032981)4.14998256
10NADH dehydrogenase complex assembly (GO:0010257)4.14998256
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.14998256
12mitochondrial respiratory chain complex assembly (GO:0033108)4.04112835
13L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.00105073
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.95445981
15signal peptide processing (GO:0006465)3.92433507
16water-soluble vitamin biosynthetic process (GO:0042364)3.86571157
17nucleotide transmembrane transport (GO:1901679)3.86403765
18proteasome assembly (GO:0043248)3.69418257
19NADH metabolic process (GO:0006734)3.65013037
20DNA deamination (GO:0045006)3.58868750
21cullin deneddylation (GO:0010388)3.57891772
22nucleoside diphosphate catabolic process (GO:0009134)3.57380715
23positive regulation of mitochondrial fission (GO:0090141)3.55945999
24hydrogen ion transmembrane transport (GO:1902600)3.55354756
25C-terminal protein lipidation (GO:0006501)3.52117804
26endosome to melanosome transport (GO:0035646)3.50208651
27endosome to pigment granule transport (GO:0043485)3.50208651
28protein localization to cilium (GO:0061512)3.50075697
29branched-chain amino acid catabolic process (GO:0009083)3.45763630
30aminoglycoside antibiotic metabolic process (GO:0030647)3.43144061
31L-methionine salvage (GO:0071267)3.36573536
32L-methionine biosynthetic process (GO:0071265)3.36573536
33amino acid salvage (GO:0043102)3.36573536
34protein deneddylation (GO:0000338)3.32191867
35proton transport (GO:0015992)3.31593561
36peptidyl-histidine modification (GO:0018202)3.29492338
37hydrogen transport (GO:0006818)3.28703164
38GPI anchor metabolic process (GO:0006505)3.23982361
39metallo-sulfur cluster assembly (GO:0031163)3.22739359
40iron-sulfur cluster assembly (GO:0016226)3.22739359
41purine nucleoside triphosphate biosynthetic process (GO:0009145)3.22131955
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.18521354
43termination of RNA polymerase III transcription (GO:0006386)3.18521354
44C-terminal protein amino acid modification (GO:0018410)3.16459192
45ATP biosynthetic process (GO:0006754)3.12709555
46purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.10037074
47transferrin transport (GO:0033572)3.09686205
48respiratory electron transport chain (GO:0022904)3.09626664
49oligosaccharide catabolic process (GO:0009313)3.06435357
50aerobic respiration (GO:0009060)3.06380975
51positive regulation of protein homodimerization activity (GO:0090073)3.06239343
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05078551
53presynaptic membrane assembly (GO:0097105)3.04889977
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03918389
55electron transport chain (GO:0022900)3.02624045
56GTP biosynthetic process (GO:0006183)3.01574215
57behavioral response to nicotine (GO:0035095)3.01531928
58protein neddylation (GO:0045116)2.99745376
59inner mitochondrial membrane organization (GO:0007007)2.99217678
60regulation of mitochondrial translation (GO:0070129)2.99117016
61intracellular protein transmembrane import (GO:0044743)2.98937407
62ubiquinone biosynthetic process (GO:0006744)2.98239463
63quinone biosynthetic process (GO:1901663)2.98239463
64tricarboxylic acid cycle (GO:0006099)2.97125379
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.96974337
66positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.96177641
67developmental pigmentation (GO:0048066)2.95234050
68platelet dense granule organization (GO:0060155)2.93832955
69phagosome maturation (GO:0090382)2.93027034
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92877560
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.92877560
72intracellular pH reduction (GO:0051452)2.92612905
73mannosylation (GO:0097502)2.92314708
74ATP hydrolysis coupled proton transport (GO:0015991)2.91621628
75energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.91621628
76ferric iron transport (GO:0015682)2.91384626
77trivalent inorganic cation transport (GO:0072512)2.91384626
78glycosphingolipid catabolic process (GO:0046479)2.89353383
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.88546631
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.87669578
81signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.87669578
82signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.87669578
83response to redox state (GO:0051775)2.85971971
84aldehyde catabolic process (GO:0046185)2.85388432
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.84578510
86exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84377017
87pH reduction (GO:0045851)2.84034410
88regulation of cilium movement (GO:0003352)2.84032320
89cellular ketone body metabolic process (GO:0046950)2.83748484
90anterograde synaptic vesicle transport (GO:0048490)2.83657317
91negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.82139184
92signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81986388
93intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81986388
94intraciliary transport (GO:0042073)2.81618434
95oxidative phosphorylation (GO:0006119)2.80689146
96tRNA processing (GO:0008033)2.78775015
97purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.78333342
98presynaptic membrane organization (GO:0097090)2.77892315
99ubiquinone metabolic process (GO:0006743)2.76973327
100purine nucleotide salvage (GO:0032261)2.76442670
101negative regulation of ligase activity (GO:0051352)2.70741539
102negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.70741539
103glycoside metabolic process (GO:0016137)2.70683452
1047-methylguanosine mRNA capping (GO:0006370)2.69039633
105branched-chain amino acid metabolic process (GO:0009081)2.67848033
106startle response (GO:0001964)2.67415774
1077-methylguanosine RNA capping (GO:0009452)2.66531810
108RNA capping (GO:0036260)2.66531810
109ribonucleoside triphosphate biosynthetic process (GO:0009201)2.65621875
110signal transduction involved in DNA integrity checkpoint (GO:0072401)2.65231155
111signal transduction involved in DNA damage checkpoint (GO:0072422)2.65231155
112regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.64933416
113ATP synthesis coupled proton transport (GO:0015986)2.64880514
114energy coupled proton transport, down electrochemical gradient (GO:0015985)2.64880514
115viral protein processing (GO:0019082)2.63822271
116signal transduction involved in cell cycle checkpoint (GO:0072395)2.63806154
117quinone metabolic process (GO:1901661)2.63482133
118deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.63443185
119regulation of oxidative phosphorylation (GO:0002082)2.63330184
120cell differentiation involved in metanephros development (GO:0072202)2.63306711
121positive regulation of TOR signaling (GO:0032008)2.62471540
122protein targeting to mitochondrion (GO:0006626)2.62414502
123purine-containing compound salvage (GO:0043101)2.62050310
124heart process (GO:0003015)2.61945234
125heart contraction (GO:0060047)2.61945234
126inositol phosphate catabolic process (GO:0071545)2.61920294
127establishment of protein localization to mitochondrion (GO:0072655)2.61388852
128negative regulation of telomere maintenance (GO:0032205)2.61045059
129glycolipid catabolic process (GO:0019377)2.60912632
130dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.60064698
131methionine biosynthetic process (GO:0009086)2.59810625
132dopamine transport (GO:0015872)2.59089552
133lactate metabolic process (GO:0006089)2.58944647
134protein-cofactor linkage (GO:0018065)2.58087875
135mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.57366532
136phosphorylated carbohydrate dephosphorylation (GO:0046838)2.57266227
137inositol phosphate dephosphorylation (GO:0046855)2.57266227
138extracellular negative regulation of signal transduction (GO:1900116)2.56342113
139extracellular regulation of signal transduction (GO:1900115)2.56342113
140nonmotile primary cilium assembly (GO:0035058)2.56136400
141antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.54101323
142GPI anchor biosynthetic process (GO:0006506)2.53988797
143nucleotide transport (GO:0006862)2.50560665
144ceramide catabolic process (GO:0046514)2.48961663
145rRNA methylation (GO:0031167)2.48893287
146N-acetylglucosamine metabolic process (GO:0006044)2.48693066
147rRNA modification (GO:0000154)2.47646771
148glucosamine-containing compound catabolic process (GO:1901072)2.47194061
149superoxide anion generation (GO:0042554)2.45480430
150regulation of pigment cell differentiation (GO:0050932)2.44449203
151preassembly of GPI anchor in ER membrane (GO:0016254)2.43957208
152regulation of mitochondrial fission (GO:0090140)2.42569547
153regulation of cellular amino acid metabolic process (GO:0006521)2.42466969
154glucosamine-containing compound metabolic process (GO:1901071)2.40936262
155adenosine metabolic process (GO:0046085)2.40197300

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.77488671
2GBX2_23144817_ChIP-Seq_PC3_Human3.66206063
3ZNF274_21170338_ChIP-Seq_K562_Hela3.30439285
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.22446060
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.10161200
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.04244098
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69829549
8SRF_21415370_ChIP-Seq_HL-1_Mouse2.69663104
9PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.58131047
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41804973
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38860624
12* GABP_17652178_ChIP-ChIP_JURKAT_Human2.36760571
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33722389
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32986852
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28695643
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.25759379
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13891500
18FOXP3_21729870_ChIP-Seq_TREG_Human2.10425397
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.09078802
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04529543
21VDR_22108803_ChIP-Seq_LS180_Human1.99450246
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.96784201
23TAF15_26573619_Chip-Seq_HEK293_Human1.93378063
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.80599610
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75676074
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75555621
27FUS_26573619_Chip-Seq_HEK293_Human1.75310124
28IRF1_19129219_ChIP-ChIP_H3396_Human1.66221119
29TP53_22573176_ChIP-Seq_HFKS_Human1.64372457
30* GABP_19822575_ChIP-Seq_HepG2_Human1.63527331
31MYC_18940864_ChIP-ChIP_HL60_Human1.63332870
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61080314
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57399561
34P300_19829295_ChIP-Seq_ESCs_Human1.55799394
35* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52133822
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49910307
37DCP1A_22483619_ChIP-Seq_HELA_Human1.49135869
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.49015593
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44374158
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.43975311
41FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.41783370
42STAT3_18555785_Chip-Seq_ESCs_Mouse1.41440090
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36134595
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35607220
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.34761788
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34365875
47EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33616908
48ER_23166858_ChIP-Seq_MCF-7_Human1.33248077
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32274600
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32103063
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.31884262
52P53_22387025_ChIP-Seq_ESCs_Mouse1.31125705
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28872039
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28258090
55NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28258090
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28007024
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.27028506
58RUNX1_27457419_Chip-Seq_LIVER_Mouse1.26268653
59SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25370132
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.24746479
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.24239827
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24239827
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.23902624
64E2F1_18555785_Chip-Seq_ESCs_Mouse1.23252220
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23089461
66EWS_26573619_Chip-Seq_HEK293_Human1.22521366
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21415612
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21368335
69IGF1R_20145208_ChIP-Seq_DFB_Human1.21325201
70GATA1_22025678_ChIP-Seq_K562_Human1.20126308
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19618028
72ELK1_19687146_ChIP-ChIP_HELA_Human1.16346635
73PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.16062755
74NMYC_18555785_Chip-Seq_ESCs_Mouse1.15977342
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15863608
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15210880
77SOX2_18555785_Chip-Seq_ESCs_Mouse1.14764759
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13374122
79TTF2_22483619_ChIP-Seq_HELA_Human1.11292043
80SMAD4_21799915_ChIP-Seq_A2780_Human1.10994018
81P300_18555785_Chip-Seq_ESCs_Mouse1.10809141
82ELK1_22589737_ChIP-Seq_MCF10A_Human1.10401842
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10278876
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09829651
85EED_16625203_ChIP-ChIP_MESCs_Mouse1.09545160
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09397280
87GATA3_21878914_ChIP-Seq_MCF-7_Human1.09252629
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08941999
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08841784
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08742654
91IRF8_21731497_ChIP-ChIP_J774_Mouse1.08653539
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08397765
93IRF8_22096565_ChIP-ChIP_GC-B_Human1.08221468
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08210213
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07194779
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07116208
97CIITA_25753668_ChIP-Seq_RAJI_Human1.06998773
98AR_20517297_ChIP-Seq_VCAP_Human1.06448474
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.06006995
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.05354889
101SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04871260
102HTT_18923047_ChIP-ChIP_STHdh_Human1.03955557
103HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02161344
104ZFX_18555785_Chip-Seq_ESCs_Mouse1.02055954
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00836232
106OCT4_18555785_Chip-Seq_ESCs_Mouse1.00109224
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00050376
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99769154
109* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99498420
110* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99189659
111KLF4_18555785_Chip-Seq_ESCs_Mouse0.99154839
112CRX_20693478_ChIP-Seq_RETINA_Mouse0.99051904
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98929857
114PU1_27457419_Chip-Seq_LIVER_Mouse0.98745746
115VDR_23849224_ChIP-Seq_CD4+_Human0.98724949
116EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98423718
117MYC_19829295_ChIP-Seq_ESCs_Human0.98168890
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98139043
119HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97610874
120NANOG_19829295_ChIP-Seq_ESCs_Human0.97514376
121SOX2_19829295_ChIP-Seq_ESCs_Human0.97514376
122IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97294035
123CBP_20019798_ChIP-Seq_JUKART_Human0.97294035
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97135174
125ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96711149
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96360070
127* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96325645
128SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96083060
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95330646
130FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95236161
131JUN_21703547_ChIP-Seq_K562_Human0.94968786
132ERG_20517297_ChIP-Seq_VCAP_Human0.94922881
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94903628
134* NCOR_22424771_ChIP-Seq_293T_Human0.94728975
135KDM5A_27292631_Chip-Seq_BREAST_Human0.94548247
136CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93391519
137EZH2_22144423_ChIP-Seq_EOC_Human0.92268690
138CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91793276
139FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91620777
140BCAT_22108803_ChIP-Seq_LS180_Human0.89690509
141POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88296108
142* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87318987
143FOXH1_21741376_ChIP-Seq_EPCs_Human0.85909033
144* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85656902
145SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85498081

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002876_abnormal_thyroid_physiology3.42364300
2MP0001188_hyperpigmentation3.35251771
3MP0005171_absent_coat_pigmentation3.14296858
4MP0009697_abnormal_copulation2.85366226
5MP0005646_abnormal_pituitary_gland2.77758858
6MP0002837_dystrophic_cardiac_calcinosis2.66625062
7MP0001986_abnormal_taste_sensitivity2.65811660
8MP0010386_abnormal_urinary_bladder2.61800803
9MP0003195_calcinosis2.44651936
10MP0006072_abnormal_retinal_apoptosis2.36513759
11MP0002102_abnormal_ear_morphology2.29838018
12MP0004147_increased_porphyrin_level2.22294419
13MP0005670_abnormal_white_adipose2.18547361
14MP0005379_endocrine/exocrine_gland_phen2.15912099
15MP0003186_abnormal_redox_activity2.15255656
16MP0005645_abnormal_hypothalamus_physiol2.10115761
17MP0003011_delayed_dark_adaptation2.09236038
18MP0002736_abnormal_nociception_after2.07544084
19MP0006292_abnormal_olfactory_placode2.02826615
20MP0008877_abnormal_DNA_methylation2.02679655
21MP0005503_abnormal_tendon_morphology1.91926290
22MP0001764_abnormal_homeostasis1.89259949
23MP0003880_abnormal_central_pattern1.80573916
24MP0000749_muscle_degeneration1.80269402
25MP0008260_abnormal_autophagy1.78085457
26MP0003787_abnormal_imprinting1.77299552
27MP0003806_abnormal_nucleotide_metabolis1.75863545
28MP0008058_abnormal_DNA_repair1.74490256
29MP0004043_abnormal_pH_regulation1.67989016
30MP0000015_abnormal_ear_pigmentation1.65420785
31MP0003786_premature_aging1.62691763
32MP0000681_abnormal_thyroid_gland1.61954576
33MP0002638_abnormal_pupillary_reflex1.59134173
34MP0001905_abnormal_dopamine_level1.59062311
35MP0001968_abnormal_touch/_nociception1.58120314
36MP0002163_abnormal_gland_morphology1.56946063
37MP0006036_abnormal_mitochondrial_physio1.55600325
38MP0008875_abnormal_xenobiotic_pharmacok1.54620476
39MP0003136_yellow_coat_color1.54610415
40MP0005084_abnormal_gallbladder_morpholo1.48011118
41MP0001984_abnormal_olfaction1.46626335
42MP0008995_early_reproductive_senescence1.40765888
43MP0004084_abnormal_cardiac_muscle1.40741903
44MP0002653_abnormal_ependyma_morphology1.40219179
45MP0000013_abnormal_adipose_tissue1.40211502
46MP0005174_abnormal_tail_pigmentation1.39484381
47MP0004215_abnormal_myocardial_fiber1.39333003
48MP0005410_abnormal_fertilization1.39310559
49MP0000566_synostosis1.38833324
50MP0004133_heterotaxia1.34710290
51MP0005409_darkened_coat_color1.34549199
52MP0002735_abnormal_chemical_nociception1.33985031
53MP0001542_abnormal_bone_strength1.30625725
54MP0000678_abnormal_parathyroid_gland1.26668321
55MP0002909_abnormal_adrenal_gland1.25410741
56MP0002090_abnormal_vision1.24360740
57MP0000372_irregular_coat_pigmentation1.23383335
58MP0004142_abnormal_muscle_tone1.22919760
59MP0008438_abnormal_cutaneous_collagen1.22588912
60MP0008789_abnormal_olfactory_epithelium1.22526803
61MP0004036_abnormal_muscle_relaxation1.20554506
62MP0003950_abnormal_plasma_membrane1.19203295
63MP0008872_abnormal_physiological_respon1.18109468
64MP0000631_abnormal_neuroendocrine_gland1.17408030
65MP0005058_abnormal_lysosome_morphology1.17200403
66MP0002095_abnormal_skin_pigmentation1.17165394
67MP0009046_muscle_twitch1.17117793
68MP0003183_abnormal_peptide_metabolism1.16056326
69MP0003724_increased_susceptibility_to1.13763234
70MP0005075_abnormal_melanosome_morpholog1.12943573
71MP0002972_abnormal_cardiac_muscle1.12756728
72MP0002272_abnormal_nervous_system1.09689514
73MP0003718_maternal_effect1.09330327
74MP0002733_abnormal_thermal_nociception1.08906298
75MP0002557_abnormal_social/conspecific_i1.06450378
76MP0009780_abnormal_chondrocyte_physiolo1.05068931
77* MP0006035_abnormal_mitochondrial_morpho1.04497681
78* MP0000230_abnormal_systemic_arterial1.03765160
79MP0009745_abnormal_behavioral_response1.02033413
80MP0002132_abnormal_respiratory_system1.01801885
81MP0005423_abnormal_somatic_nervous1.00828936
82MP0002148_abnormal_hypersensitivity_rea1.00112457
83MP0000569_abnormal_digit_pigmentation1.00095363
84MP0002067_abnormal_sensory_capabilities0.98409249
85MP0006276_abnormal_autonomic_nervous0.96179521
86MP0002928_abnormal_bile_duct0.95912664
87MP0005367_renal/urinary_system_phenotyp0.95523167
88MP0000516_abnormal_urinary_system0.95523167
89MP0002751_abnormal_autonomic_nervous0.95145131
90MP0009764_decreased_sensitivity_to0.94705099
91MP0003172_abnormal_lysosome_physiology0.94684261
92MP0002139_abnormal_hepatobiliary_system0.94129982
93MP0000639_abnormal_adrenal_gland0.92932947
94* MP0005332_abnormal_amino_acid0.91884386
95MP0000343_altered_response_to0.90809515
96MP0002734_abnormal_mechanical_nocicepti0.90473377
97MP0003941_abnormal_skin_development0.89386559
98MP0003122_maternal_imprinting0.88883107
99MP0002064_seizures0.88501647
100MP0005636_abnormal_mineral_homeostasis0.88501130
101MP0005535_abnormal_body_temperature0.87489641
102MP0003283_abnormal_digestive_organ0.87412489
103MP0001501_abnormal_sleep_pattern0.86562342
104MP0009785_altered_susceptibility_to0.85777077
105MP0004484_altered_response_of0.85255268
106MP0001502_abnormal_circadian_rhythm0.84933965
107MP0002572_abnormal_emotion/affect_behav0.84476975
108MP0001486_abnormal_startle_reflex0.84383631
109* MP0002229_neurodegeneration0.83223403
110MP0005595_abnormal_vascular_smooth0.83076901
111MP0005620_abnormal_muscle_contractility0.83001710
112MP0005499_abnormal_olfactory_system0.82723749
113MP0005394_taste/olfaction_phenotype0.82723749
114MP0000049_abnormal_middle_ear0.81620468
115MP0002160_abnormal_reproductive_system0.81501876
116* MP0001963_abnormal_hearing_physiology0.80859047
117MP0005386_behavior/neurological_phenoty0.80255440
118MP0004924_abnormal_behavior0.80255440
119MP0010329_abnormal_lipoprotein_level0.80191238
120MP0001664_abnormal_digestion0.79966348
121MP0003137_abnormal_impulse_conducting0.79777227
122MP0001529_abnormal_vocalization0.79702573
123MP0005551_abnormal_eye_electrophysiolog0.79348322
124* MP0001756_abnormal_urination0.79235816
125* MP0000026_abnormal_inner_ear0.79181213
126MP0005330_cardiomyopathy0.79156894
127MP0003121_genomic_imprinting0.78187267
128MP0002277_abnormal_respiratory_mucosa0.77913695
129MP0008775_abnormal_heart_ventricle0.77578730
130MP0003279_aneurysm0.77413325
131MP0004782_abnormal_surfactant_physiolog0.76725864
132MP0000538_abnormal_urinary_bladder0.76180232
133MP0004145_abnormal_muscle_electrophysio0.76104978
134MP0001485_abnormal_pinna_reflex0.75838182
135MP0003690_abnormal_glial_cell0.75759936
136MP0005389_reproductive_system_phenotype0.75301025
137MP0005253_abnormal_eye_physiology0.73736305
138MP0001919_abnormal_reproductive_system0.73343570
139MP0001324_abnormal_eye_pigmentation0.72265777
140MP0002693_abnormal_pancreas_physiology0.72142706
141MP0002938_white_spotting0.71659241
142MP0002138_abnormal_hepatobiliary_system0.71466465
143* MP0001186_pigmentation_phenotype0.70822996
144MP0005220_abnormal_exocrine_pancreas0.70595772
145MP0002127_abnormal_cardiovascular_syste0.69717897
146MP0001970_abnormal_pain_threshold0.67873257
147* MP0004085_abnormal_heartbeat0.67426463

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.14994274
2Hepatic necrosis (HP:0002605)3.97619285
3Abnormal mitochondria in muscle tissue (HP:0008316)3.94595976
4Hepatocellular necrosis (HP:0001404)3.94075311
5Hypothermia (HP:0002045)3.85744600
6Mitochondrial inheritance (HP:0001427)3.84754965
7Increased CSF lactate (HP:0002490)3.56168894
8Acute encephalopathy (HP:0006846)3.47838019
9Pancreatic fibrosis (HP:0100732)3.41565719
10Medial flaring of the eyebrow (HP:0010747)3.32056983
11Nephrogenic diabetes insipidus (HP:0009806)3.30254133
12Progressive macrocephaly (HP:0004481)3.29387482
13Decreased electroretinogram (ERG) amplitude (HP:0000654)3.28574341
14Nephronophthisis (HP:0000090)3.17707175
15True hermaphroditism (HP:0010459)3.04808294
16Type I transferrin isoform profile (HP:0003642)3.02334976
17Generalized aminoaciduria (HP:0002909)3.01100520
18Pancreatic cysts (HP:0001737)2.94179193
19Congenital primary aphakia (HP:0007707)2.91154561
203-Methylglutaconic aciduria (HP:0003535)2.83487999
21* Lactic acidosis (HP:0003128)2.81193698
22Renal cortical cysts (HP:0000803)2.77935407
23Exercise intolerance (HP:0003546)2.77351948
24Gait imbalance (HP:0002141)2.75165420
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.69656114
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.69656114
27Exertional dyspnea (HP:0002875)2.68522052
28Abolished electroretinogram (ERG) (HP:0000550)2.65879322
29Hyperventilation (HP:0002883)2.65266052
30Abnormal hair whorl (HP:0010721)2.65134717
31Increased serum lactate (HP:0002151)2.60707413
32Abnormality of glycolysis (HP:0004366)2.59887268
33Increased serum pyruvate (HP:0003542)2.59887268
34Abnormal biliary tract physiology (HP:0012439)2.59379872
35Bile duct proliferation (HP:0001408)2.59379872
36Methylmalonic acidemia (HP:0002912)2.59070853
37Large for gestational age (HP:0001520)2.54701327
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.53823303
39Cerebral edema (HP:0002181)2.53801776
40Dicarboxylic aciduria (HP:0003215)2.52728148
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52728148
42Neuroendocrine neoplasm (HP:0100634)2.52574745
43Pheochromocytoma (HP:0002666)2.51740591
44Methylmalonic aciduria (HP:0012120)2.51362014
45Ketoacidosis (HP:0001993)2.51124685
46Decreased circulating renin level (HP:0003351)2.50533532
47Poor coordination (HP:0002370)2.47512084
48Type II lissencephaly (HP:0007260)2.47070537
49Optic disc pallor (HP:0000543)2.46600340
50Abnormality of the renal medulla (HP:0100957)2.46227443
51Renal Fanconi syndrome (HP:0001994)2.45928130
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.44834041
53Ketosis (HP:0001946)2.39916038
54Hyperalaninemia (HP:0003348)2.39137849
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39137849
56Abnormality of alanine metabolism (HP:0010916)2.39137849
57Aplasia/hypoplasia of the uterus (HP:0008684)2.36612513
58Focal motor seizures (HP:0011153)2.35385226
59Attenuation of retinal blood vessels (HP:0007843)2.34533068
60Respiratory failure (HP:0002878)2.32799861
61Chronic hepatic failure (HP:0100626)2.30783929
62Abnormality of the renal cortex (HP:0011035)2.29546348
63Abnormal protein glycosylation (HP:0012346)2.28017718
64Abnormal glycosylation (HP:0012345)2.28017718
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.28017718
66Abnormal protein N-linked glycosylation (HP:0012347)2.28017718
67Congenital sensorineural hearing impairment (HP:0008527)2.26629890
68Proximal tubulopathy (HP:0000114)2.26185047
69Abnormal rod and cone electroretinograms (HP:0008323)2.23369622
70Conjugated hyperbilirubinemia (HP:0002908)2.22809782
71Keratoconus (HP:0000563)2.22224737
72Increased corneal curvature (HP:0100692)2.22224737
73Testicular atrophy (HP:0000029)2.21581910
74Decreased central vision (HP:0007663)2.20388907
75Lipid accumulation in hepatocytes (HP:0006561)2.19972687
76Congenital stationary night blindness (HP:0007642)2.19673829
77Abnormality of renal resorption (HP:0011038)2.19424732
78Hypoplasia of the fovea (HP:0007750)2.19016302
79Aplasia/Hypoplasia of the fovea (HP:0008060)2.19016302
80Patchy hypopigmentation of hair (HP:0011365)2.17712398
81Thyroid-stimulating hormone excess (HP:0002925)2.16766293
82Epileptic encephalopathy (HP:0200134)2.16296413
83Leukodystrophy (HP:0002415)2.15680612
84Osteomalacia (HP:0002749)2.13765682
85Lethargy (HP:0001254)2.13150404
86Retinal dysplasia (HP:0007973)2.10377025
87Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08473755
88Renal tubular dysfunction (HP:0000124)2.08375968
89Occipital encephalocele (HP:0002085)2.06022909
90Hyperglycinemia (HP:0002154)2.05971440
91Increased hepatocellular lipid droplets (HP:0006565)2.05932593
92White forelock (HP:0002211)2.04615854
93Abnormal drinking behavior (HP:0030082)2.03569780
94Polydipsia (HP:0001959)2.03569780
95Hemiparesis (HP:0001269)2.02774832
96Abnormality of urine glucose concentration (HP:0011016)2.02446930
97Glycosuria (HP:0003076)2.02446930
98Muscle fiber atrophy (HP:0100295)2.00499400
99Reduced antithrombin III activity (HP:0001976)1.99228886
100Type 2 muscle fiber atrophy (HP:0003554)1.97999490
101Cerebral palsy (HP:0100021)1.97414981
102Hyperaldosteronism (HP:0000859)1.97057693
103Abnormality of fatty-acid metabolism (HP:0004359)1.96554023
104Opisthotonus (HP:0002179)1.95417180
105Emotional lability (HP:0000712)1.95072098
106Genital tract atresia (HP:0001827)1.94798098
107Vaginal atresia (HP:0000148)1.93763647
108Sclerocornea (HP:0000647)1.93257497
109Left ventricular hypertrophy (HP:0001712)1.93110852
110Progressive microcephaly (HP:0000253)1.90967525
111Vacuolated lymphocytes (HP:0001922)1.90425231
112Cystic liver disease (HP:0006706)1.89760690
113* Microvesicular hepatic steatosis (HP:0001414)1.88715848
114Cerebellar dysplasia (HP:0007033)1.88283995
115Brushfield spots (HP:0001088)1.84325672
116Polyphagia (HP:0002591)1.83842265
117Abnormality of the fovea (HP:0000493)1.83748002
118Hypoplasia of the uterus (HP:0000013)1.83478424
119Constricted visual fields (HP:0001133)1.82714580
120Oligomenorrhea (HP:0000876)1.81463331
121Intestinal atresia (HP:0011100)1.80302907
122Blindness (HP:0000618)1.80211147
123Aplasia/Hypoplasia of the tongue (HP:0010295)1.78839821
124Increased muscle lipid content (HP:0009058)1.78583926
125Congenital hepatic fibrosis (HP:0002612)1.78344911
126Aplasia/Hypoplasia of the lens (HP:0008063)1.78245516
127Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77652621
128Increased intramyocellular lipid droplets (HP:0012240)1.77400278
129Hypoglycemic coma (HP:0001325)1.75715496
130Abnormality of the renal collecting system (HP:0004742)1.74343085
131Hyperglycinuria (HP:0003108)1.73008115
132Atonic seizures (HP:0010819)1.71560409
133Hypokalemic alkalosis (HP:0001949)1.71269040
134Febrile seizures (HP:0002373)1.69821884
135CNS demyelination (HP:0007305)1.67548670
136Abnormality of vitamin B metabolism (HP:0004340)1.65653497
137* Prolonged neonatal jaundice (HP:0006579)1.65235253
138Abnormality of the vitamin B12 metabolism (HP:0004341)1.64691940
139Molar tooth sign on MRI (HP:0002419)1.64620475
140Abnormality of midbrain morphology (HP:0002418)1.64620475
141Abnormality of serum amino acid levels (HP:0003112)1.64200291

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.80936674
2MAP4K24.71971656
3STK163.47163799
4VRK23.13082274
5ZAK2.96106175
6MAP3K122.79562670
7IRAK32.62980036
8PRPF4B2.58245531
9AKT32.48628523
10MYLK2.38942457
11TNIK2.18009179
12ADRBK22.13533606
13TLK11.92808936
14PINK11.84625512
15MAP2K71.82132116
16INSRR1.81791654
17MKNK21.75658636
18MST41.63049176
19STK38L1.61885777
20BCKDK1.59899126
21TAOK31.58302185
22NME11.57868773
23MAPKAPK31.56631096
24BMPR21.54652436
25CSNK1G31.53660389
26TXK1.51050394
27EIF2AK31.48834602
28IRAK41.46958399
29EIF2AK11.44774424
30PLK21.44049801
31BMPR1B1.42675608
32PIK3CG1.42369062
33IRAK11.41162625
34OBSCN1.38823461
35CSNK1G21.36878648
36GRK71.36748954
37TSSK61.34146867
38PLK41.34052135
39BRAF1.33879883
40NEK61.30252758
41CCNB11.29895833
42YES11.25138672
43TRIM281.24283880
44EIF2AK21.22876726
45CDK81.22543034
46ARAF1.22540242
47CSNK1G11.21646384
48OXSR11.15095080
49CSNK1A1L1.14471868
50CDK191.13951312
51MAP3K141.11214418
52CAMKK21.11102575
53MKNK11.11017078
54MAPKAPK51.04013406
55TAOK21.02087510
56MAP3K41.01616676
57BUB10.98004091
58DYRK20.97320585
59LIMK10.96519613
60DAPK10.96482673
61MUSK0.95931193
62SGK20.95173951
63TESK10.92227317
64PHKG10.90634654
65PHKG20.90634654
66PAK30.90497601
67VRK10.88987458
68NME20.87799868
69TIE10.86852053
70TNK20.86721329
71IKBKB0.85657567
72MAPK130.84402619
73ERBB30.84294332
74SIK30.84265951
75PRKCE0.83356525
76PDK20.81798685
77PIK3CA0.79045732
78PDK40.78799737
79PDK30.78799737
80NUAK10.78468667
81IRAK20.77494111
82PBK0.77166648
83TEC0.76321005
84CAMK2D0.76181872
85STK240.74381121
86NTRK30.73982681
87PTK2B0.71446266
88CDK30.71207221
89WNK30.70619873
90PIM20.70575283
91SRPK10.70115618
92RPS6KA50.69989440
93KDR0.69699780
94PRKD30.69312486
95MAPK150.69067047
96TESK20.68610106
97EPHA30.65316502
98SGK4940.64695541
99SGK2230.64695541
100CAMK2B0.60418569
101CAMK2A0.58405790
102ADRBK10.57649955
103MAPK70.57205857
104FLT30.52930337
105PRKCG0.52688895
106CSNK1A10.49178993
107PRKCQ0.48843790
108CSF1R0.48784022
109NEK10.48366908
110PLK30.48326189
111ACVR1B0.46202888
112GRK50.45605853
113FRK0.44868123
114DAPK20.44812483
115NEK90.42661211
116DAPK30.42398221
117BRD40.42199273
118WNK40.41537138
119ATR0.41337775
120GRK10.41334876
121CAMK2G0.41000081
122ILK0.39980136
123PRKCA0.38585258
124FES0.38576483
125SGK30.38116816
126EPHA40.38068380
127ITK0.37261243
128MAP2K60.37221554
129ABL10.37071573
130CSNK2A10.35676596
131PKN10.35286228
132PLK10.35044854
133TRPM70.34979037
134BCR0.34924293
135NLK0.34748466
136LMTK20.34261239
137CAMK10.34174920
138TGFBR20.32935814
139STK390.32646584
140PRKACA0.32605162
141KIT0.32512366
142ABL20.32331423
143PRKCD0.32233948
144SYK0.32120336
145MAP2K30.31853685
146WEE10.31775707
147BRSK20.29998423

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.71714385
2Protein export_Homo sapiens_hsa030603.68633623
3Proteasome_Homo sapiens_hsa030502.98594361
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.92119773
5Parkinsons disease_Homo sapiens_hsa050122.75534408
6Collecting duct acid secretion_Homo sapiens_hsa049662.69191091
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.32460689
8Sulfur metabolism_Homo sapiens_hsa009202.25914443
9RNA polymerase_Homo sapiens_hsa030202.14487231
10Fatty acid elongation_Homo sapiens_hsa000622.13685323
11Vibrio cholerae infection_Homo sapiens_hsa051102.11724469
12Alzheimers disease_Homo sapiens_hsa050101.97866037
13Asthma_Homo sapiens_hsa053101.92407550
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.90523809
15Huntingtons disease_Homo sapiens_hsa050161.85949508
16Propanoate metabolism_Homo sapiens_hsa006401.82654797
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.76300178
18Rheumatoid arthritis_Homo sapiens_hsa053231.75134432
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72825576
20Other glycan degradation_Homo sapiens_hsa005111.66120583
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64730602
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57770679
23Regulation of autophagy_Homo sapiens_hsa041401.57183197
24Ribosome_Homo sapiens_hsa030101.55919417
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51945483
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.50763375
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47507542
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45394197
29Synaptic vesicle cycle_Homo sapiens_hsa047211.41565681
30Nicotine addiction_Homo sapiens_hsa050331.39839056
31One carbon pool by folate_Homo sapiens_hsa006701.36662153
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.31612894
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.31268680
34Arachidonic acid metabolism_Homo sapiens_hsa005901.30873065
35Pyrimidine metabolism_Homo sapiens_hsa002401.30033221
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24727845
37* Peroxisome_Homo sapiens_hsa041461.24419489
38Homologous recombination_Homo sapiens_hsa034401.22405958
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20001165
40Purine metabolism_Homo sapiens_hsa002301.16884560
41Pyruvate metabolism_Homo sapiens_hsa006201.16436327
42RNA degradation_Homo sapiens_hsa030181.13905937
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13243488
44Phagosome_Homo sapiens_hsa041451.11450743
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11088288
46Nitrogen metabolism_Homo sapiens_hsa009101.08770077
47Tryptophan metabolism_Homo sapiens_hsa003801.07279707
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06676824
49Fructose and mannose metabolism_Homo sapiens_hsa000511.04101737
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.03743935
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03471441
52Lysosome_Homo sapiens_hsa041421.02135832
53Metabolic pathways_Homo sapiens_hsa011001.01229044
54Taste transduction_Homo sapiens_hsa047421.00449706
55Sphingolipid metabolism_Homo sapiens_hsa006000.98669015
56beta-Alanine metabolism_Homo sapiens_hsa004100.98220614
57Fanconi anemia pathway_Homo sapiens_hsa034600.97192858
58Carbon metabolism_Homo sapiens_hsa012000.95977070
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94997984
60Phenylalanine metabolism_Homo sapiens_hsa003600.94779096
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93226611
62Cardiac muscle contraction_Homo sapiens_hsa042600.93143617
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90353940
64Selenocompound metabolism_Homo sapiens_hsa004500.88298595
65Galactose metabolism_Homo sapiens_hsa000520.84421687
66Nucleotide excision repair_Homo sapiens_hsa034200.83541021
67Vitamin digestion and absorption_Homo sapiens_hsa049770.81170750
68Arginine and proline metabolism_Homo sapiens_hsa003300.77341015
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77139962
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76042943
71Basal transcription factors_Homo sapiens_hsa030220.76000290
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75346188
73Fatty acid degradation_Homo sapiens_hsa000710.75057322
74Type I diabetes mellitus_Homo sapiens_hsa049400.73986711
75Fatty acid metabolism_Homo sapiens_hsa012120.72972547
76Tyrosine metabolism_Homo sapiens_hsa003500.71976070
77Sulfur relay system_Homo sapiens_hsa041220.70060273
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.68363241
79Folate biosynthesis_Homo sapiens_hsa007900.67880562
80Linoleic acid metabolism_Homo sapiens_hsa005910.67167332
81Mismatch repair_Homo sapiens_hsa034300.66273263
82Serotonergic synapse_Homo sapiens_hsa047260.64779379
83Autoimmune thyroid disease_Homo sapiens_hsa053200.63077400
84Butanoate metabolism_Homo sapiens_hsa006500.62504072
85Phototransduction_Homo sapiens_hsa047440.61700979
86Primary immunodeficiency_Homo sapiens_hsa053400.60056467
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59643197
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58770961
89Non-homologous end-joining_Homo sapiens_hsa034500.57814049
90Antigen processing and presentation_Homo sapiens_hsa046120.56309968
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55631087
92Glutathione metabolism_Homo sapiens_hsa004800.55562314
93Morphine addiction_Homo sapiens_hsa050320.55112944
94Vitamin B6 metabolism_Homo sapiens_hsa007500.54859724
95Histidine metabolism_Homo sapiens_hsa003400.53903344
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53233662
97Graft-versus-host disease_Homo sapiens_hsa053320.52520704
98N-Glycan biosynthesis_Homo sapiens_hsa005100.52381008
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51746092
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.51163351
101Olfactory transduction_Homo sapiens_hsa047400.50659645
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49218717
103Allograft rejection_Homo sapiens_hsa053300.46677745
104DNA replication_Homo sapiens_hsa030300.46327247
105Starch and sucrose metabolism_Homo sapiens_hsa005000.44856856
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.44621001
107Spliceosome_Homo sapiens_hsa030400.44544742
108RNA transport_Homo sapiens_hsa030130.44481893
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44295874
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.44084965
111Chemical carcinogenesis_Homo sapiens_hsa052040.42700224
112Circadian rhythm_Homo sapiens_hsa047100.41034966
113Biosynthesis of amino acids_Homo sapiens_hsa012300.40628972
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40037146
115Retinol metabolism_Homo sapiens_hsa008300.39562336
116Base excision repair_Homo sapiens_hsa034100.39272835
117Insulin secretion_Homo sapiens_hsa049110.38528799
118Ether lipid metabolism_Homo sapiens_hsa005650.37840270
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37451443
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36095008
121Calcium signaling pathway_Homo sapiens_hsa040200.35075852
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33583007
123Steroid biosynthesis_Homo sapiens_hsa001000.33133969
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32873915

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