MPV17L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)6.21771920
2urate metabolic process (GO:0046415)6.09120050
3aminoglycoside antibiotic metabolic process (GO:0030647)5.64090213
4organic cation transport (GO:0015695)5.63132221
5drug transport (GO:0015893)5.32962871
6lysine metabolic process (GO:0006553)5.19076190
7lysine catabolic process (GO:0006554)5.19076190
8behavioral response to nicotine (GO:0035095)5.04124109
9phosphate ion transport (GO:0006817)4.78143120
10nonribosomal peptide biosynthetic process (GO:0019184)4.66274217
11excretion (GO:0007588)4.47034093
12cysteine metabolic process (GO:0006534)4.46441373
13fucose catabolic process (GO:0019317)4.33759878
14L-fucose metabolic process (GO:0042354)4.33759878
15L-fucose catabolic process (GO:0042355)4.33759878
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.32429583
17glutathione biosynthetic process (GO:0006750)4.30408141
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.21318717
19phosphate ion transmembrane transport (GO:0035435)4.13543113
20energy coupled proton transport, down electrochemical gradient (GO:0015985)4.13199997
21ATP synthesis coupled proton transport (GO:0015986)4.13199997
22tryptophan catabolic process (GO:0006569)4.07935083
23indole-containing compound catabolic process (GO:0042436)4.07935083
24indolalkylamine catabolic process (GO:0046218)4.07935083
25polyol transport (GO:0015791)4.06653266
26metanephric tubule development (GO:0072170)4.05002911
27metanephric nephron tubule development (GO:0072234)4.05002911
28aspartate family amino acid catabolic process (GO:0009068)3.97353668
29aromatic amino acid family catabolic process (GO:0009074)3.96412285
30short-chain fatty acid metabolic process (GO:0046459)3.96390236
31peptide biosynthetic process (GO:0043043)3.86596066
32regulation of hippo signaling (GO:0035330)3.85276109
33glyoxylate metabolic process (GO:0046487)3.84602976
34negative regulation of translation, ncRNA-mediated (GO:0040033)3.83127386
35regulation of translation, ncRNA-mediated (GO:0045974)3.83127386
36negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.83127386
37response to mercury ion (GO:0046689)3.78987782
38neuron cell-cell adhesion (GO:0007158)3.76288716
39tryptophan metabolic process (GO:0006568)3.65924804
40dopamine transport (GO:0015872)3.64307113
41metanephric nephron epithelium development (GO:0072243)3.64251237
42respiratory electron transport chain (GO:0022904)3.63895968
43dopamine biosynthetic process (GO:0042416)3.60655818
44axon ensheathment in central nervous system (GO:0032291)3.58515587
45central nervous system myelination (GO:0022010)3.58515587
46erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.57641938
47L-phenylalanine catabolic process (GO:0006559)3.57641938
48detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.56501142
49electron transport chain (GO:0022900)3.53608159
50response to phenylpropanoid (GO:0080184)3.53556424
51glutamate metabolic process (GO:0006536)3.53375340
52sulfation (GO:0051923)3.45990630
53quaternary ammonium group transport (GO:0015697)3.45616138
54renal absorption (GO:0070293)3.43069973
55erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.42776145
56L-phenylalanine metabolic process (GO:0006558)3.42776145
57DNA deamination (GO:0045006)3.42640644
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.40023527
59cellular ketone body metabolic process (GO:0046950)3.39903667
60metanephric epithelium development (GO:0072207)3.35520779
61interkinetic nuclear migration (GO:0022027)3.34631043
62indole-containing compound metabolic process (GO:0042430)3.31638258
63cellular biogenic amine catabolic process (GO:0042402)3.31405230
64amine catabolic process (GO:0009310)3.31405230
65positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.30403516
66regulation of gene silencing by RNA (GO:0060966)3.27577410
67regulation of posttranscriptional gene silencing (GO:0060147)3.27577410
68regulation of gene silencing by miRNA (GO:0060964)3.27577410
69drug catabolic process (GO:0042737)3.20371011
70kynurenine metabolic process (GO:0070189)3.20349217
71vitamin D metabolic process (GO:0042359)3.19793456
72detection of light stimulus involved in sensory perception (GO:0050962)3.13880051
73detection of light stimulus involved in visual perception (GO:0050908)3.13880051
74branched-chain amino acid metabolic process (GO:0009081)3.13370475
75proline metabolic process (GO:0006560)3.13216938
76presynaptic membrane assembly (GO:0097105)3.10973248
77modified amino acid transport (GO:0072337)3.10354984
78acetyl-CoA metabolic process (GO:0006084)3.10033284
79exogenous drug catabolic process (GO:0042738)3.07025441
80nephron tubule morphogenesis (GO:0072078)3.07011514
81nephron epithelium morphogenesis (GO:0072088)3.07011514
82oligosaccharide catabolic process (GO:0009313)3.06601986
83response to pheromone (GO:0019236)3.03737426
84aromatic amino acid family metabolic process (GO:0009072)3.03309211
85indolalkylamine metabolic process (GO:0006586)3.00565356
86NAD biosynthetic process (GO:0009435)2.98437393
87hydrogen ion transmembrane transport (GO:1902600)2.98036210
88neural tube formation (GO:0001841)2.97547002
89cAMP catabolic process (GO:0006198)2.96819746
90kidney morphogenesis (GO:0060993)2.96068429
91transepithelial transport (GO:0070633)2.96030592
92glutathione derivative biosynthetic process (GO:1901687)2.95005953
93glutathione derivative metabolic process (GO:1901685)2.95005953
94nephron tubule development (GO:0072080)2.94410985
95protein K11-linked deubiquitination (GO:0035871)2.94392849
96ATP hydrolysis coupled proton transport (GO:0015991)2.93711537
97energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.93711537
98establishment of protein localization to Golgi (GO:0072600)2.93709452
99ketone body metabolic process (GO:1902224)2.93438958
100branched-chain amino acid catabolic process (GO:0009083)2.92610135
101neurotransmitter biosynthetic process (GO:0042136)2.91144419
102vocalization behavior (GO:0071625)2.90833732
103presynaptic membrane organization (GO:0097090)2.88731219
104trivalent inorganic anion homeostasis (GO:0072506)2.87408166
105phosphate ion homeostasis (GO:0055062)2.87408166
106sodium ion transport (GO:0006814)2.85663818
107chaperone-mediated protein transport (GO:0072321)2.85379151
108serine family amino acid catabolic process (GO:0009071)2.84845954
109homocysteine metabolic process (GO:0050667)2.84472646
110glycoside metabolic process (GO:0016137)2.84085083
111neuronal action potential (GO:0019228)2.82327878
112serine family amino acid metabolic process (GO:0009069)2.82088354
113regulation of establishment of cell polarity (GO:2000114)2.80819727
114toxin transport (GO:1901998)2.79584945
115primary amino compound metabolic process (GO:1901160)2.79384408
116glutathione metabolic process (GO:0006749)2.79232493
117aldehyde catabolic process (GO:0046185)2.78441602
118positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.78060797
119neuronal action potential propagation (GO:0019227)2.77923791
120positive regulation of fatty acid oxidation (GO:0046321)2.77763635
121axoneme assembly (GO:0035082)2.76609564
122cellular response to ammonium ion (GO:0071242)2.76266482
123cellular modified amino acid catabolic process (GO:0042219)2.75060267
124ionotropic glutamate receptor signaling pathway (GO:0035235)2.74668865
125cilium or flagellum-dependent cell motility (GO:0001539)2.74335671
126water-soluble vitamin biosynthetic process (GO:0042364)2.72363215
127negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72354409
128benzene-containing compound metabolic process (GO:0042537)2.72056207
129L-ascorbic acid metabolic process (GO:0019852)2.68643719
130rRNA catabolic process (GO:0016075)2.68624674
131cyclic nucleotide catabolic process (GO:0009214)2.68516138
132hydrogen transport (GO:0006818)2.68195105
133gamma-aminobutyric acid transport (GO:0015812)2.67917961
134oxidative demethylation (GO:0070989)2.67786079
135positive regulation of developmental pigmentation (GO:0048087)2.66997427
136reflex (GO:0060004)2.66560920
137regulation of establishment or maintenance of cell polarity (GO:0032878)2.65961257
138proton transport (GO:0015992)2.65123018
139long-chain fatty acid biosynthetic process (GO:0042759)2.62815150
140regulation of pigment cell differentiation (GO:0050932)2.61748464
141epithelial cilium movement (GO:0003351)2.61706713
142transferrin transport (GO:0033572)2.61464029
143regulation of action potential (GO:0098900)2.61166349
144regulation of memory T cell differentiation (GO:0043380)2.61118321
145cellular response to exogenous dsRNA (GO:0071360)2.59963966
146cellular amino acid catabolic process (GO:0009063)2.59716127
147alpha-amino acid catabolic process (GO:1901606)2.59153810
148reciprocal DNA recombination (GO:0035825)2.58769708
149reciprocal meiotic recombination (GO:0007131)2.58769708
150calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.57322044
151serotonin metabolic process (GO:0042428)2.57145476
152protein K48-linked deubiquitination (GO:0071108)2.56912959
153preassembly of GPI anchor in ER membrane (GO:0016254)2.56278015
154negative regulation of mast cell activation (GO:0033004)2.55301218
1553-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.53322844
156purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.53322844
157peristalsis (GO:0030432)2.50370256
158piRNA metabolic process (GO:0034587)2.47391654
159positive regulation of mRNA catabolic process (GO:0061014)2.47288725
160behavioral response to ethanol (GO:0048149)2.46652754
161cilium movement (GO:0003341)2.46615415
162cellular response to ethanol (GO:0071361)2.46394433
163positive regulation of defense response to virus by host (GO:0002230)2.46293393
164renal tubule morphogenesis (GO:0061333)2.45001653
165positive regulation of CREB transcription factor activity (GO:0032793)2.44214578
166regulation of hexokinase activity (GO:1903299)2.44104585
167regulation of glucokinase activity (GO:0033131)2.44104585
168thyroid hormone metabolic process (GO:0042403)2.43244018
169cellular response to ATP (GO:0071318)2.42982263
170monoubiquitinated protein deubiquitination (GO:0035520)2.42918381
171membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40810960
172positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.40274470
173auditory receptor cell stereocilium organization (GO:0060088)2.40057725
174regulation of nuclear cell cycle DNA replication (GO:0033262)2.40002221
175protein K63-linked deubiquitination (GO:0070536)2.39544021
176regulation of mesoderm development (GO:2000380)2.38232080
177negative regulation of telomere maintenance (GO:0032205)2.37394422
178alanine transport (GO:0032328)2.36058861
179negative regulation of sodium ion transport (GO:0010766)2.34666269
180S-adenosylmethionine metabolic process (GO:0046500)2.34520212
181positive regulation of fatty acid transport (GO:2000193)2.34451512
182photoreceptor cell maintenance (GO:0045494)2.33331013
183cornea development in camera-type eye (GO:0061303)2.32867948
184spinal cord motor neuron differentiation (GO:0021522)2.32633357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.01336244
2ZNF274_21170338_ChIP-Seq_K562_Hela3.55222206
3EZH2_22144423_ChIP-Seq_EOC_Human3.50352478
4VDR_22108803_ChIP-Seq_LS180_Human3.08571962
5TAF15_26573619_Chip-Seq_HEK293_Human2.58191038
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52534593
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.50486312
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48897382
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45842960
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41802798
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38225279
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26118377
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24170292
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19925142
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.09279504
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.05683080
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03952150
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03442107
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02637815
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02506219
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00636392
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97186352
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.96770343
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.96770343
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95774783
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91828202
27EWS_26573619_Chip-Seq_HEK293_Human1.80659740
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79348620
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78208107
30STAT3_23295773_ChIP-Seq_U87_Human1.77137586
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.75427958
32P300_19829295_ChIP-Seq_ESCs_Human1.71924042
33REST_21632747_ChIP-Seq_MESCs_Mouse1.70240581
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.69720684
35BCAT_22108803_ChIP-Seq_LS180_Human1.69600392
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.66713476
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61581346
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61354464
39TCF4_23295773_ChIP-Seq_U87_Human1.60002462
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.59935967
41ER_23166858_ChIP-Seq_MCF-7_Human1.53756794
42FUS_26573619_Chip-Seq_HEK293_Human1.53334491
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.51838724
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.50834803
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50352493
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50352493
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50042650
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48953846
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48246129
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47042224
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45181847
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44552094
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44076676
54CBP_20019798_ChIP-Seq_JUKART_Human1.44076676
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41668587
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40746239
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38988109
58* REST_18959480_ChIP-ChIP_MESCs_Mouse1.38829561
59* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38271890
60SMAD4_21799915_ChIP-Seq_A2780_Human1.38239743
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.36097089
62IGF1R_20145208_ChIP-Seq_DFB_Human1.34449725
63RNF2_27304074_Chip-Seq_NSC_Mouse1.34418900
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.32763813
65TP53_16413492_ChIP-PET_HCT116_Human1.31935934
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31825550
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30962230
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30353538
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29969621
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.29949604
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29843773
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27836596
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.27765300
74TCF4_22108803_ChIP-Seq_LS180_Human1.27507487
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27197246
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26221073
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25293510
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.25173715
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24888951
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24379981
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24300549
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23234067
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.22785981
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22599601
85STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22409153
86AHR_22903824_ChIP-Seq_MCF-7_Human1.21261739
87* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21061967
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20762598
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.20523749
90TP53_22573176_ChIP-Seq_HFKS_Human1.20496650
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19367862
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.18498876
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17893283
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.17250218
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16934041
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.16934041
97GATA3_21878914_ChIP-Seq_MCF-7_Human1.14776318
98AR_21572438_ChIP-Seq_LNCaP_Human1.12893540
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.12206253
100P300_18555785_Chip-Seq_ESCs_Mouse1.11815381
101DROSHA_22980978_ChIP-Seq_HELA_Human1.11382253
102RUNX1_27457419_Chip-Seq_LIVER_Mouse1.11064980
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10444537
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09954873
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09634986
106CDX2_22108803_ChIP-Seq_LS180_Human1.09581550
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.09536228
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09464385
109P53_22387025_ChIP-Seq_ESCs_Mouse1.09313654
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08865485
111FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08559350
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08133386
113HOXB7_26014856_ChIP-Seq_BT474_Human1.07447028
114RARB_27405468_Chip-Seq_BRAIN_Mouse1.06727604
115SOX2_18555785_Chip-Seq_ESCs_Mouse1.06575159
116AR_25329375_ChIP-Seq_VCAP_Human1.06265263
117CMYC_18555785_Chip-Seq_ESCs_Mouse1.05733729
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.05515052
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.04848366
120KLF4_18555785_Chip-Seq_ESCs_Mouse1.04579613
121ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04160880
122STAT3_18555785_Chip-Seq_ESCs_Mouse1.04129156
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03881307
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03835665
125RXR_22108803_ChIP-Seq_LS180_Human1.03014812
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02165506
127AR_20517297_ChIP-Seq_VCAP_Human1.02037824
128CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01885656
129JUN_21703547_ChIP-Seq_K562_Human1.01813931
130OCT4_18555785_Chip-Seq_ESCs_Mouse1.00230341
131ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00184766
132FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99797988
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99588388
134* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99304553
135TP53_18474530_ChIP-ChIP_U2OS_Human0.98647764
136KDM2B_26808549_Chip-Seq_REH_Human0.98548257
137NANOG_19829295_ChIP-Seq_ESCs_Human0.98344436
138SOX2_19829295_ChIP-Seq_ESCs_Human0.98344436
139EZH2_27294783_Chip-Seq_NPCs_Mouse0.98035936
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98031461
141ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97999634
142SMAD1_18555785_Chip-Seq_ESCs_Mouse0.94686527
143RUNX2_22187159_ChIP-Seq_PCA_Human0.94389890
144CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93297219
145FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92020672
146ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91784819
147STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91757189
148NMYC_18555785_Chip-Seq_ESCs_Mouse0.91650637
149ZFX_18555785_Chip-Seq_ESCs_Mouse0.91506052
150P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89470943
151IRF1_19129219_ChIP-ChIP_H3396_Human0.89368898

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.82372196
2MP0004043_abnormal_pH_regulation4.41197665
3MP0003880_abnormal_central_pattern3.74926832
4MP0000569_abnormal_digit_pigmentation3.53087017
5MP0005332_abnormal_amino_acid3.38739017
6MP0003646_muscle_fatigue3.37077267
7MP0003195_calcinosis3.25358719
8MP0004019_abnormal_vitamin_homeostasis3.20831352
9MP0002139_abnormal_hepatobiliary_system2.66581248
10MP0008877_abnormal_DNA_methylation2.65097271
11MP0004859_abnormal_synaptic_plasticity2.49990359
12MP0005423_abnormal_somatic_nervous2.37543189
13MP0001765_abnormal_ion_homeostasis2.31473264
14MP0009745_abnormal_behavioral_response2.24501541
15MP0003635_abnormal_synaptic_transmissio2.18389913
16MP0004270_analgesia2.13327277
17MP0002064_seizures2.12849199
18MP0008875_abnormal_xenobiotic_pharmacok2.07108309
19MP0002876_abnormal_thyroid_physiology2.05967356
20MP0009046_muscle_twitch2.02031333
21MP0004885_abnormal_endolymph2.00599976
22MP0009643_abnormal_urine_homeostasis1.99539074
23MP0002138_abnormal_hepatobiliary_system1.96216690
24MP0005377_hearing/vestibular/ear_phenot1.93417036
25MP0003878_abnormal_ear_physiology1.93417036
26MP0001486_abnormal_startle_reflex1.92881177
27MP0003787_abnormal_imprinting1.91802212
28MP0005636_abnormal_mineral_homeostasis1.90996771
29MP0001968_abnormal_touch/_nociception1.90768304
30MP0001905_abnormal_dopamine_level1.86445085
31MP0001529_abnormal_vocalization1.83990486
32MP0005174_abnormal_tail_pigmentation1.83501458
33MP0008057_abnormal_DNA_replication1.82899050
34MP0005645_abnormal_hypothalamus_physiol1.82839550
35MP0001756_abnormal_urination1.80893518
36MP0002837_dystrophic_cardiac_calcinosis1.80318299
37MP0002063_abnormal_learning/memory/cond1.79154411
38MP0002272_abnormal_nervous_system1.79133595
39MP0002572_abnormal_emotion/affect_behav1.75921898
40MP0000427_abnormal_hair_cycle1.75707572
41MP0004147_increased_porphyrin_level1.75237148
42MP0002638_abnormal_pupillary_reflex1.74787625
43MP0004742_abnormal_vestibular_system1.70744373
44MP0001440_abnormal_grooming_behavior1.70235440
45MP0002736_abnormal_nociception_after1.69623408
46MP0002734_abnormal_mechanical_nocicepti1.66843867
47MP0004145_abnormal_muscle_electrophysio1.66314650
48MP0004130_abnormal_muscle_cell1.65830886
49MP0003252_abnormal_bile_duct1.64442239
50MP0002735_abnormal_chemical_nociception1.64429706
51MP0006276_abnormal_autonomic_nervous1.62080164
52MP0005409_darkened_coat_color1.60703796
53MP0003136_yellow_coat_color1.60181205
54MP0002067_abnormal_sensory_capabilities1.58348301
55MP0004142_abnormal_muscle_tone1.55664156
56MP0010329_abnormal_lipoprotein_level1.53090377
57MP0003045_fibrosis1.52791217
58MP0000383_abnormal_hair_follicle1.52611968
59MP0001188_hyperpigmentation1.50399909
60MP0005167_abnormal_blood-brain_barrier1.49874515
61MP0000778_abnormal_nervous_system1.48100445
62MP0002136_abnormal_kidney_physiology1.42147789
63MP0002102_abnormal_ear_morphology1.39749974
64MP0005253_abnormal_eye_physiology1.38924014
65MP0001485_abnormal_pinna_reflex1.36212099
66MP0000538_abnormal_urinary_bladder1.33848044
67MP0005535_abnormal_body_temperature1.32618159
68MP0001501_abnormal_sleep_pattern1.32032607
69MP0000920_abnormal_myelination1.30706133
70MP0003329_amyloid_beta_deposits1.30490844
71MP0002822_catalepsy1.26176224
72MP0002928_abnormal_bile_duct1.25774742
73MP0008961_abnormal_basal_metabolism1.25020394
74MP0005085_abnormal_gallbladder_physiolo1.24461702
75MP0006072_abnormal_retinal_apoptosis1.21756000
76MP0009379_abnormal_foot_pigmentation1.21531152
77MP0001963_abnormal_hearing_physiology1.20443100
78MP0005389_reproductive_system_phenotype1.20371495
79MP0002160_abnormal_reproductive_system1.18058178
80MP0002938_white_spotting1.17981182
81MP0000631_abnormal_neuroendocrine_gland1.17933779
82MP0000372_irregular_coat_pigmentation1.16801266
83MP0001970_abnormal_pain_threshold1.15587820
84MP0005451_abnormal_body_composition1.14896305
85MP0003011_delayed_dark_adaptation1.08083759
86MP0003879_abnormal_hair_cell1.07616280
87MP0002733_abnormal_thermal_nociception1.07502748
88MP0004924_abnormal_behavior1.07485246
89MP0005386_behavior/neurological_phenoty1.07485246
90MP0002066_abnormal_motor_capabilities/c1.06667945
91MP0001986_abnormal_taste_sensitivity1.05830125
92MP0002557_abnormal_social/conspecific_i1.04737746
93MP0001919_abnormal_reproductive_system1.04362778
94MP0003890_abnormal_embryonic-extraembry1.04042721
95MP0005084_abnormal_gallbladder_morpholo1.03714195
96MP0005670_abnormal_white_adipose1.02637930
97MP0000566_synostosis1.02207592
98MP0005448_abnormal_energy_balance1.01847622
99MP0004215_abnormal_myocardial_fiber1.00635402
100MP0000026_abnormal_inner_ear0.99842494
101MP0005365_abnormal_bile_salt0.97907869
102MP0005646_abnormal_pituitary_gland0.97000999
103MP0008872_abnormal_physiological_respon0.96487042
104MP0002693_abnormal_pancreas_physiology0.95858063
105MP0006036_abnormal_mitochondrial_physio0.94772340
106MP0005075_abnormal_melanosome_morpholog0.94070818
107MP0006035_abnormal_mitochondrial_morpho0.93202237
108MP0002229_neurodegeneration0.92281149
109MP0002168_other_aberrant_phenotype0.91444034
110MP0010386_abnormal_urinary_bladder0.90775998
111MP0003186_abnormal_redox_activity0.90644581
112MP0000230_abnormal_systemic_arterial0.90453872
113MP0001661_extended_life_span0.90245285
114MP0005551_abnormal_eye_electrophysiolog0.89087372
115MP0005584_abnormal_enzyme/coenzyme_acti0.88102643
116MP0005310_abnormal_salivary_gland0.87543870
117MP0002069_abnormal_eating/drinking_beha0.86576307
118MP0001984_abnormal_olfaction0.86154047
119MP0005410_abnormal_fertilization0.84958039
120MP0003950_abnormal_plasma_membrane0.84583549
121MP0005379_endocrine/exocrine_gland_phen0.84421175
122MP0003938_abnormal_ear_development0.84295460
123MP0001177_atelectasis0.83917661
124MP0006292_abnormal_olfactory_placode0.83414844
125MP0001764_abnormal_homeostasis0.82913346
126MP0001664_abnormal_digestion0.82648565
127MP0002882_abnormal_neuron_morphology0.82360405
128MP0001873_stomach_inflammation0.81963565
129MP0005171_absent_coat_pigmentation0.81360732
130MP0002184_abnormal_innervation0.80993270
131MP0001958_emphysema0.80643614
132MP0008775_abnormal_heart_ventricle0.80536278
133MP0002009_preneoplasia0.80208828
134MP0003690_abnormal_glial_cell0.78865566
135MP0002095_abnormal_skin_pigmentation0.78233565
136MP0004381_abnormal_hair_follicle0.77914542
137MP0003718_maternal_effect0.77885753
138MP0005195_abnormal_posterior_eye0.77010734
139MP0002653_abnormal_ependyma_morphology0.76772218
140MP0004133_heterotaxia0.76730319
141MP0003638_abnormal_response/metabolism_0.74299323
142MP0002752_abnormal_somatic_nervous0.73791267
143MP0005266_abnormal_metabolism0.73683430
144MP0003137_abnormal_impulse_conducting0.72745985
145MP0003953_abnormal_hormone_level0.72590482
146MP0001324_abnormal_eye_pigmentation0.72409895
147MP0001666_abnormal_nutrient_absorption0.71607335
148MP0000470_abnormal_stomach_morphology0.71571601
149MP0000955_abnormal_spinal_cord0.71372242
150MP0003631_nervous_system_phenotype0.68347429
151MP0003806_abnormal_nucleotide_metabolis0.66850137
152MP0005395_other_phenotype0.62917412
153MP0003634_abnormal_glial_cell0.62912625
154MP0003633_abnormal_nervous_system0.62873510

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)6.88833870
2Hypomagnesemia (HP:0002917)6.69468335
3Metabolic alkalosis (HP:0200114)6.63128567
4Hypokalemic alkalosis (HP:0001949)6.03331647
5Hyperactive renin-angiotensin system (HP:0000841)5.65718193
6Abnormality of magnesium homeostasis (HP:0004921)5.55702314
7Polyuria (HP:0000103)5.37080584
8Gout (HP:0001997)5.12318675
9Abnormal urine output (HP:0012590)5.07247917
10Abnormality of chloride homeostasis (HP:0011422)4.92306457
11Abnormality of renal excretion (HP:0011036)4.70656611
12Pancreatic cysts (HP:0001737)4.63858669
13Polydipsia (HP:0001959)4.46975394
14Abnormal drinking behavior (HP:0030082)4.46975394
15Renal salt wasting (HP:0000127)4.29467391
16Hyperaldosteronism (HP:0000859)4.26350431
17Proximal tubulopathy (HP:0000114)4.22299379
18Tetany (HP:0001281)4.20324200
19Abnormality of renin-angiotensin system (HP:0000847)4.06790234
20Pancreatic fibrosis (HP:0100732)3.96221297
21Increased purine levels (HP:0004368)3.94222949
22Hyperuricemia (HP:0002149)3.94222949
23Hyperglycinuria (HP:0003108)3.92485630
24Alkalosis (HP:0001948)3.92416416
25Abnormality of midbrain morphology (HP:0002418)3.80735332
26Molar tooth sign on MRI (HP:0002419)3.80735332
27Abnormality of the renal cortex (HP:0011035)3.77393463
28Genetic anticipation (HP:0003743)3.75559174
29Congenital stationary night blindness (HP:0007642)3.72691336
30True hermaphroditism (HP:0010459)3.71153105
31Nephronophthisis (HP:0000090)3.59145871
32Abnormality of the renal medulla (HP:0100957)3.41336922
33Gaze-evoked nystagmus (HP:0000640)3.39471529
34Abnormality of serine family amino acid metabolism (HP:0010894)3.35962670
35Abnormality of glycine metabolism (HP:0010895)3.35962670
36Abnormality of glutamine family amino acid metabolism (HP:0010902)3.25954581
37Progressive cerebellar ataxia (HP:0002073)3.24448033
38Acute encephalopathy (HP:0006846)3.18170378
39Hyperventilation (HP:0002883)3.14853554
40Large for gestational age (HP:0001520)3.13927207
41Attenuation of retinal blood vessels (HP:0007843)3.04782778
42Delayed CNS myelination (HP:0002188)3.03366427
43Hyperphosphaturia (HP:0003109)2.99858633
44Chronic hepatic failure (HP:0100626)2.97380980
45Glycosuria (HP:0003076)2.96885490
46Abnormality of urine glucose concentration (HP:0011016)2.96885490
47Renal tubular acidosis (HP:0001947)2.96885393
48Ketoacidosis (HP:0001993)2.94517260
49Type II lissencephaly (HP:0007260)2.93386687
50Cystic liver disease (HP:0006706)2.92667011
51Abnormality of purine metabolism (HP:0004352)2.90778387
52Clumsiness (HP:0002312)2.85944714
53Protruding tongue (HP:0010808)2.83870518
54Abnormal urine phosphate concentration (HP:0012599)2.81616933
55Acute necrotizing encephalopathy (HP:0006965)2.81516926
56Hypercalciuria (HP:0002150)2.78548457
57Hypokalemia (HP:0002900)2.76214702
58Abnormality of renal resorption (HP:0011038)2.70858969
59Abolished electroretinogram (ERG) (HP:0000550)2.70855649
60Decreased circulating renin level (HP:0003351)2.65307190
61Abnormality of alanine metabolism (HP:0010916)2.63818909
62Hyperalaninemia (HP:0003348)2.63818909
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63818909
64Focal motor seizures (HP:0011153)2.63557925
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.60851465
66Confusion (HP:0001289)2.58365853
67Inability to walk (HP:0002540)2.55666379
68Febrile seizures (HP:0002373)2.53098812
69Abnormal mitochondria in muscle tissue (HP:0008316)2.51889809
70Renal tubular dysfunction (HP:0000124)2.47941450
71Birth length less than 3rd percentile (HP:0003561)2.45155640
72Renal cortical cysts (HP:0000803)2.44705500
73Abnormality of the pons (HP:0007361)2.43830885
74Medial flaring of the eyebrow (HP:0010747)2.43642936
75Abnormality of potassium homeostasis (HP:0011042)2.40970067
76Ketosis (HP:0001946)2.40678801
77Myokymia (HP:0002411)2.40123466
78Progressive inability to walk (HP:0002505)2.39461625
79Congenital, generalized hypertrichosis (HP:0004540)2.38561225
80Furrowed tongue (HP:0000221)2.38518901
81Hyperglycinemia (HP:0002154)2.37282038
82Cerebral edema (HP:0002181)2.36072925
83Progressive macrocephaly (HP:0004481)2.36009685
84Stomach cancer (HP:0012126)2.34209106
85Mitochondrial inheritance (HP:0001427)2.32696356
86Generalized hypopigmentation of hair (HP:0011358)2.32267375
87Generalized aminoaciduria (HP:0002909)2.30959456
88Widely spaced teeth (HP:0000687)2.26984249
89Hypoplasia of the pons (HP:0012110)2.26028098
90Nephrocalcinosis (HP:0000121)2.24258084
91Broad-based gait (HP:0002136)2.23702460
92Aplasia/Hypoplasia of the tibia (HP:0005772)2.23325467
93Abnormal eating behavior (HP:0100738)2.22409151
94Congenital hepatic fibrosis (HP:0002612)2.22187616
95Keratoconus (HP:0000563)2.18520933
96Increased corneal curvature (HP:0100692)2.18520933
97Lethargy (HP:0001254)2.17758344
98Decreased central vision (HP:0007663)2.16906485
99Rickets (HP:0002748)2.16134932
100Delayed epiphyseal ossification (HP:0002663)2.16019843
101Vomiting (HP:0002013)2.15926889
102Cerebellar dysplasia (HP:0007033)2.14603321
103Abnormality of sodium homeostasis (HP:0010931)2.12534875
104Abnormality of nucleobase metabolism (HP:0010932)2.11076728
105Patellar aplasia (HP:0006443)2.10443764
106Hypothermia (HP:0002045)2.09223951
107Lissencephaly (HP:0001339)2.08403792
108Dynein arm defect of respiratory motile cilia (HP:0012255)2.07765298
109Absent/shortened dynein arms (HP:0200106)2.07765298
110Hypophosphatemic rickets (HP:0004912)2.07154149
111Facial shape deformation (HP:0011334)2.06724557
112Potter facies (HP:0002009)2.06724557
113Hyponatremia (HP:0002902)2.05250998
114Hepatocellular necrosis (HP:0001404)2.01529334
115Increased CSF lactate (HP:0002490)2.00699629
116Bile duct proliferation (HP:0001408)2.00473665
117Abnormal biliary tract physiology (HP:0012439)2.00473665
118Fetal akinesia sequence (HP:0001989)1.99943525
119Methylmalonic aciduria (HP:0012120)1.99691084
120Pendular nystagmus (HP:0012043)1.98738480
121Dehydration (HP:0001944)1.98303346
122Sclerocornea (HP:0000647)1.97524824
123Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96611796
124Hypophosphatemia (HP:0002148)1.95639361
125Aplasia/Hypoplasia of the patella (HP:0006498)1.95077869
1263-Methylglutaconic aciduria (HP:0003535)1.93608227
127Renal Fanconi syndrome (HP:0001994)1.92801525
128Male pseudohermaphroditism (HP:0000037)1.92509918
129Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91277435
130Polyphagia (HP:0002591)1.90895558
131Abnormality of the renal collecting system (HP:0004742)1.90418201
132Metabolic acidosis (HP:0001942)1.88664928
133Nephrolithiasis (HP:0000787)1.88356007
134Aplasia/Hypoplasia of the tongue (HP:0010295)1.87570425
135Chorioretinal atrophy (HP:0000533)1.85724101
136Widely patent fontanelles and sutures (HP:0004492)1.85552956
137Hemiparesis (HP:0001269)1.85384108
138Abnormality of fatty-acid metabolism (HP:0004359)1.85315929
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84239735
140Enlarged kidneys (HP:0000105)1.84133158
141Duplicated collecting system (HP:0000081)1.83763597
142Absent speech (HP:0001344)1.83072966
143Bulbous nose (HP:0000414)1.82763593
144Anencephaly (HP:0002323)1.81442172
145Hepatic necrosis (HP:0002605)1.80899718
146Bony spicule pigmentary retinopathy (HP:0007737)1.80259548
147Thyroiditis (HP:0100646)1.79613597
148Increased serum pyruvate (HP:0003542)1.78781665
149Abnormality of glycolysis (HP:0004366)1.78781665
150Abnormality of the nasal septum (HP:0000419)1.78643642
151Abnormality of aromatic amino acid family metabolism (HP:0004338)1.78084768
152Dialeptic seizures (HP:0011146)1.77794752
153Abnormal rod and cone electroretinograms (HP:0008323)1.77679381
154Leukodystrophy (HP:0002415)1.76845862
155Clubbing of toes (HP:0100760)1.76828839
156Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.75853739
157Hypoplastic iliac wings (HP:0002866)1.75574058
158Severe muscular hypotonia (HP:0006829)1.73603307
159Lactic acidosis (HP:0003128)1.73246239
160Tubular atrophy (HP:0000092)1.72880332
161Dicarboxylic aciduria (HP:0003215)1.72352169
162Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72352169
163Gait imbalance (HP:0002141)1.71869728
164Concave nail (HP:0001598)1.69735055
165Adrenal overactivity (HP:0002717)1.68832343
166Optic disc pallor (HP:0000543)1.67631797
167Abnormality of sulfur amino acid metabolism (HP:0004339)1.66237087
168Epileptic encephalopathy (HP:0200134)1.65588517
169Congenital sensorineural hearing impairment (HP:0008527)1.65506463
170Abnormality of the vitamin B12 metabolism (HP:0004341)1.65249265
171Vascular calcification (HP:0004934)1.65206513
172Amelogenesis imperfecta (HP:0000705)1.65089996
173Congenital primary aphakia (HP:0007707)1.64035563
174Postaxial foot polydactyly (HP:0001830)1.63428849
175Partial agenesis of the corpus callosum (HP:0001338)1.63250314
176Tachypnea (HP:0002789)1.61464178
177Fair hair (HP:0002286)1.61002131
178Aplasia/Hypoplasia of the uvula (HP:0010293)1.60976600
179Parakeratosis (HP:0001036)1.59947986
180Hypoplastic ischia (HP:0003175)1.59586065
181Limb dystonia (HP:0002451)1.59410886
182Focal seizures (HP:0007359)1.58863832

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.10442764
2WNK36.07985718
3OXSR15.83830518
4WNK44.70943217
5STK393.49086057
6ACVR1B3.46604257
7EPHA42.77650875
8CASK2.67041841
9MARK12.55068377
10PNCK2.41400166
11TAOK32.39502041
12ZAK2.08262794
13STK161.99899461
14NUAK11.82547888
15NTRK31.76343904
16TLK11.73402344
17IRAK21.69463550
18CAMKK21.67746887
19MAP4K21.66031203
20IRAK31.60126425
21TNIK1.52896306
22MAP2K71.52566999
23TXK1.50744367
24SGK2231.48201212
25SGK4941.48201212
26MAP3K41.42042212
27NME11.41807712
28PINK11.40782271
29MKNK21.39973908
30PIK3CA1.36718905
31STK38L1.34985015
32CAMK1D1.34664829
33MAP3K121.31607778
34MST41.31410272
35NLK1.27548000
36WNK11.21465323
37OBSCN1.20453469
38MAPKAPK31.17349759
39RIPK41.16756937
40BMPR21.15407308
41MINK11.13994213
42TGFBR11.10061963
43CAMK2B1.07238560
44TRPM71.06264616
45NEK61.06153519
46CDK191.04827953
47CAMK1G1.04327546
48TEC1.03097714
49BCKDK1.00908341
50MAP2K60.99697292
51GRK50.99411297
52BRSK20.98843537
53ARAF0.98661384
54IRAK10.98515722
55NTRK10.98244074
56MAPK130.97634473
57FGFR20.95981179
58PLK20.93089379
59PRKAA20.89575661
60PBK0.86877536
61MAP2K40.86689748
62PKN10.86347627
63NTRK20.84347086
64CAMK2A0.84239184
65DAPK20.82816140
66ADRBK20.81429027
67PIK3CG0.81025556
68STK380.80289958
69PHKG10.79387229
70PHKG20.79387229
71BCR0.78705696
72MAP3K70.78254152
73TNK20.77822263
74FES0.76748209
75PRKCG0.76597141
76ABL20.76294957
77SGK20.72636909
78CHUK0.72347985
79FGR0.72126010
80CDK50.70752821
81MAP3K90.69763673
82CAMK10.68465205
83PRPF4B0.68065359
84IKBKB0.67903942
85ITK0.65468080
86PRKCQ0.64711844
87PDK20.62989681
88UHMK10.61537726
89IRAK40.61129945
90SGK10.60715256
91CAMK2G0.60314207
92PRKAA10.58591618
93TIE10.58105946
94KIT0.58070775
95CAMK2D0.57836400
96CSNK1G20.57696563
97GRK70.57454666
98CSNK1G30.56451736
99PRKCE0.55952428
100ROCK20.55665406
101MELK0.54450229
102MAPKAPK50.54305514
103PRKCI0.53980840
104ERBB20.53111148
105SYK0.52379089
106DYRK20.51224473
107CAMKK10.50732632
108BRAF0.49837928
109PTK2B0.48850907
110BMPR1B0.48762652
111MAPK150.48227139
112PDK40.47430012
113PDK30.47430012
114AKT30.47299937
115PRKCZ0.46994028
116CAMK40.46561843
117STK30.45181189
118GRK60.45100613
119MAP2K10.43597721
120PRKACA0.43530237
121RPS6KA50.43186809
122ERBB40.43165286
123DYRK1A0.42913507
124VRK10.42735813
125CSNK1G10.42273893
126FGFR30.41292335
127STK110.41248355
128GRK10.40735739
129PAK30.40711888
130EPHA30.39590423
131MUSK0.39419372
132FER0.39288591
133PAK60.39177561
134IKBKE0.37607576
135MARK30.37598684
136MAPK110.37522709
137CDK140.37477547
138CDK30.36171598
139CDK150.35831021
140ADRBK10.35746341
141CDK180.35622977
142LATS10.35549241
143DAPK10.34889879
144CSNK1D0.34487392
145INSRR0.33229620
146PRKG10.33073070
147PDPK10.32282306
148PRKCA0.31861266
149NEK20.31833912
150CDK11A0.31175217
151PRKD20.30030032
152RPS6KA60.29879264
153FLT30.29576408
154LCK0.28813542
155MST1R0.28628131
156CDC42BPA0.28478510
157PLK40.28477563
158SGK30.28190977
159BTK0.27586200
160SIK20.27512868

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.01859546
2Oxidative phosphorylation_Homo sapiens_hsa001903.30681091
3Butanoate metabolism_Homo sapiens_hsa006503.25402810
4Collecting duct acid secretion_Homo sapiens_hsa049663.03602759
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.79530025
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.65011598
7Linoleic acid metabolism_Homo sapiens_hsa005912.58068804
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.51991192
9Parkinsons disease_Homo sapiens_hsa050122.45212308
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.43517845
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.39526049
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27831090
13ABC transporters_Homo sapiens_hsa020102.26004560
14Propanoate metabolism_Homo sapiens_hsa006402.25813926
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.25364450
16Nicotine addiction_Homo sapiens_hsa050332.03865896
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.00367244
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94295594
19Alzheimers disease_Homo sapiens_hsa050101.89823255
20* Peroxisome_Homo sapiens_hsa041461.80620154
21Caffeine metabolism_Homo sapiens_hsa002321.77508234
22Selenocompound metabolism_Homo sapiens_hsa004501.77396307
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.73259276
24Vitamin digestion and absorption_Homo sapiens_hsa049771.70004308
25Synaptic vesicle cycle_Homo sapiens_hsa047211.68774411
26Sulfur metabolism_Homo sapiens_hsa009201.65301010
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63117193
28Huntingtons disease_Homo sapiens_hsa050161.61963303
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.61603083
30Pyruvate metabolism_Homo sapiens_hsa006201.58885725
31Fatty acid elongation_Homo sapiens_hsa000621.57928380
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54025097
33beta-Alanine metabolism_Homo sapiens_hsa004101.54005099
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53674256
35Tryptophan metabolism_Homo sapiens_hsa003801.49651175
36Homologous recombination_Homo sapiens_hsa034401.44468625
37Glutathione metabolism_Homo sapiens_hsa004801.36871971
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33761261
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32213890
40Fanconi anemia pathway_Homo sapiens_hsa034601.29650601
41Bile secretion_Homo sapiens_hsa049761.25124972
42Arginine and proline metabolism_Homo sapiens_hsa003301.24495576
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24419887
44Cardiac muscle contraction_Homo sapiens_hsa042601.20457058
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18810421
46Steroid biosynthesis_Homo sapiens_hsa001001.18416487
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.17042498
48Dorso-ventral axis formation_Homo sapiens_hsa043201.17017365
49GABAergic synapse_Homo sapiens_hsa047271.15968302
50Circadian rhythm_Homo sapiens_hsa047101.10021837
51One carbon pool by folate_Homo sapiens_hsa006701.08803109
52RNA polymerase_Homo sapiens_hsa030201.07347605
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05974452
54Ovarian steroidogenesis_Homo sapiens_hsa049131.03627996
55Fat digestion and absorption_Homo sapiens_hsa049751.02817137
56Histidine metabolism_Homo sapiens_hsa003401.02807674
57Glutamatergic synapse_Homo sapiens_hsa047241.02528430
58Fatty acid degradation_Homo sapiens_hsa000711.01875477
59Lysine degradation_Homo sapiens_hsa003101.01344390
60Fatty acid metabolism_Homo sapiens_hsa012121.00952629
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99741018
62Mineral absorption_Homo sapiens_hsa049780.98545469
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97620357
64Fatty acid biosynthesis_Homo sapiens_hsa000610.97417957
65Taste transduction_Homo sapiens_hsa047420.96374697
66Vibrio cholerae infection_Homo sapiens_hsa051100.95491994
67Serotonergic synapse_Homo sapiens_hsa047260.91125366
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.90461303
69Basal transcription factors_Homo sapiens_hsa030220.89099364
70Gastric acid secretion_Homo sapiens_hsa049710.88487332
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87737622
72Morphine addiction_Homo sapiens_hsa050320.87460400
73Phenylalanine metabolism_Homo sapiens_hsa003600.87338822
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86834502
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84965521
76Amphetamine addiction_Homo sapiens_hsa050310.84099309
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.81800674
78Arginine biosynthesis_Homo sapiens_hsa002200.81239560
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.80871683
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80857751
81Metabolic pathways_Homo sapiens_hsa011000.79305161
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78394196
83Phototransduction_Homo sapiens_hsa047440.78100636
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76601326
85RNA degradation_Homo sapiens_hsa030180.76088015
86Primary immunodeficiency_Homo sapiens_hsa053400.73419455
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72997733
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72769625
89Pancreatic secretion_Homo sapiens_hsa049720.72282525
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71722878
91Carbon metabolism_Homo sapiens_hsa012000.70495476
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.69284233
93Salivary secretion_Homo sapiens_hsa049700.69001805
94Regulation of autophagy_Homo sapiens_hsa041400.68654871
95Protein digestion and absorption_Homo sapiens_hsa049740.67998916
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66455328
97Tyrosine metabolism_Homo sapiens_hsa003500.66158624
98Chemical carcinogenesis_Homo sapiens_hsa052040.64212042
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61867426
100Sphingolipid metabolism_Homo sapiens_hsa006000.60616360
101Complement and coagulation cascades_Homo sapiens_hsa046100.60250046
102Circadian entrainment_Homo sapiens_hsa047130.60176169
103Nitrogen metabolism_Homo sapiens_hsa009100.59234839
104Ether lipid metabolism_Homo sapiens_hsa005650.58925343
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.58788754
106PPAR signaling pathway_Homo sapiens_hsa033200.58295096
107Long-term potentiation_Homo sapiens_hsa047200.57567315
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57564464
109Oxytocin signaling pathway_Homo sapiens_hsa049210.57039996
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56629374
111Asthma_Homo sapiens_hsa053100.54035805
112Cocaine addiction_Homo sapiens_hsa050300.53754853
113Glycerolipid metabolism_Homo sapiens_hsa005610.53209259
114Rheumatoid arthritis_Homo sapiens_hsa053230.53185032
115Other glycan degradation_Homo sapiens_hsa005110.51093933
116Arachidonic acid metabolism_Homo sapiens_hsa005900.51004268
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50094448
118cAMP signaling pathway_Homo sapiens_hsa040240.49899638
119Dopaminergic synapse_Homo sapiens_hsa047280.48275257
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47381417
121Biosynthesis of amino acids_Homo sapiens_hsa012300.45813734
122Cholinergic synapse_Homo sapiens_hsa047250.45786374
123Long-term depression_Homo sapiens_hsa047300.45643538
124Renin secretion_Homo sapiens_hsa049240.45073243
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44883381
126Retinol metabolism_Homo sapiens_hsa008300.44113971
127Graft-versus-host disease_Homo sapiens_hsa053320.42849355
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42579791
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40404118
130Insulin resistance_Homo sapiens_hsa049310.39623487
131Folate biosynthesis_Homo sapiens_hsa007900.39600080
132Thyroid hormone synthesis_Homo sapiens_hsa049180.39438987
133Type II diabetes mellitus_Homo sapiens_hsa049300.39429110
134Type I diabetes mellitus_Homo sapiens_hsa049400.39335288
135Insulin secretion_Homo sapiens_hsa049110.38931580
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38589839
137Calcium signaling pathway_Homo sapiens_hsa040200.38370230
138Olfactory transduction_Homo sapiens_hsa047400.38159044
139Protein export_Homo sapiens_hsa030600.37444191
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37358773
141Starch and sucrose metabolism_Homo sapiens_hsa005000.34848347
142Axon guidance_Homo sapiens_hsa043600.34045580
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33779188
144NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33557133
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31257661
146Renin-angiotensin system_Homo sapiens_hsa046140.30508607

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