ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.59238698
2	proteasome assembly (GO:0043248)	5.02101328
3	chaperone-mediated protein transport (GO:0072321)	4.94988677
4	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.91518221
5	ribosomal small subunit assembly (GO:0000028)	4.46686519
6	telomere maintenance via semi-conservative replication (GO:0032201)	4.10624004
7	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.06064078
8	chromatin remodeling at centromere (GO:0031055)	4.04826791
9	viral transcription (GO:0019083)	4.01585901
10	DNA strand elongation involved in DNA replication (GO:0006271)	4.01310305
11	protein targeting to mitochondrion (GO:0006626)	3.95515655
12	translational termination (GO:0006415)	3.91071234
13	DNA damage response, detection of DNA damage (GO:0042769)	3.86987559
14	CENP-A containing nucleosome assembly (GO:0034080)	3.85254363
15	rRNA modification (GO:0000154)	3.84520831
16	DNA strand elongation (GO:0022616)	3.81140233
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.77874430
18	formation of translation preinitiation complex (GO:0001731)	3.74450878
19	cullin deneddylation (GO:0010388)	3.73828238
20	translational elongation (GO:0006414)	3.72649250
21	establishment of protein localization to mitochondrion (GO:0072655)	3.71895978
22	protein deneddylation (GO:0000338)	3.71411123
23	folic acid metabolic process (GO:0046655)	3.71289625
24	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.70199476
25	establishment of integrated proviral latency (GO:0075713)	3.66629103
26	regulation of mitochondrial translation (GO:0070129)	3.65767131
27	protein targeting to ER (GO:0045047)	3.64683339
28	respiratory electron transport chain (GO:0022904)	3.63954000
29	protein localization to mitochondrion (GO:0070585)	3.63253572
30	ribosomal small subunit biogenesis (GO:0042274)	3.62534571
31	NADH dehydrogenase complex assembly (GO:0010257)	3.61991913
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.61991913
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.61991913
34	oxidative phosphorylation (GO:0006119)	3.61797028
35	cotranslational protein targeting to membrane (GO:0006613)	3.57509225
36	electron transport chain (GO:0022900)	3.56493950
37	mitotic metaphase plate congression (GO:0007080)	3.55205827
38	heme biosynthetic process (GO:0006783)	3.54699541
39	protein localization to endoplasmic reticulum (GO:0070972)	3.53512274
40	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.49969241
41	spliceosomal snRNP assembly (GO:0000387)	3.49873531
42	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.42221738
43	folic acid-containing compound biosynthetic process (GO:0009396)	3.41275855
44	protein maturation by protein folding (GO:0022417)	3.39663769
45	pseudouridine synthesis (GO:0001522)	3.39492714
46	iron-sulfur cluster assembly (GO:0016226)	3.38408844
47	metallo-sulfur cluster assembly (GO:0031163)	3.38408844
48	translational initiation (GO:0006413)	3.36996532
49	protein complex biogenesis (GO:0070271)	3.35858886
50	telomere maintenance via recombination (GO:0000722)	3.34108837
51	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.34026382
52	mitochondrial respiratory chain complex assembly (GO:0033108)	3.31573052
53	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.31250162
54	DNA replication initiation (GO:0006270)	3.30200464
55	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.26766590
56	translation (GO:0006412)	3.25993119
57	ribosomal large subunit biogenesis (GO:0042273)	3.24621854
58	protein neddylation (GO:0045116)	3.24441568
59	maturation of SSU-rRNA (GO:0030490)	3.23300149
60	pteridine-containing compound biosynthetic process (GO:0042559)	3.22723356
61	regulation of cellular amino acid metabolic process (GO:0006521)	3.21738907
62	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.20380459
63	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.19469903
64	negative regulation of ligase activity (GO:0051352)	3.19469903
65	regulation of protein heterodimerization activity (GO:0043497)	3.19239963
66	transcription from mitochondrial promoter (GO:0006390)	3.18653922
67	ribonucleoprotein complex biogenesis (GO:0022613)	3.17905723
68	regulation of ubiquitin-protein transferase activity (GO:0051438)	3.17400239
69	regulation of translational termination (GO:0006449)	3.17158326
70	mitochondrial RNA metabolic process (GO:0000959)	3.17153156
71	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.15328533
72	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.13647884
73	ribosome biogenesis (GO:0042254)	3.13203855
74	viral life cycle (GO:0019058)	3.12932976
75	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.12825984
76	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.12825984
77	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.11453493
78	ribosome assembly (GO:0042255)	3.10995268
79	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.10109124
80	CTP biosynthetic process (GO:0006241)	3.10080557
81	CTP metabolic process (GO:0046036)	3.10080557
82	pentose-phosphate shunt (GO:0006098)	3.07993511
83	mitotic sister chromatid segregation (GO:0000070)	3.07909886
84	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.07855139
85	regulation of ligase activity (GO:0051340)	3.07578119
86	establishment of viral latency (GO:0019043)	3.06468008
87	protein K6-linked ubiquitination (GO:0085020)	3.06254716
88	protein-cofactor linkage (GO:0018065)	3.06077282
89	UTP biosynthetic process (GO:0006228)	3.05028844
90	heterochromatin organization (GO:0070828)	3.04723231
91	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.04653453
92	GTP biosynthetic process (GO:0006183)	3.04565017
93	heme metabolic process (GO:0042168)	3.03847948
94	GDP-mannose metabolic process (GO:0019673)	3.02772401
95	purine-containing compound salvage (GO:0043101)	3.02729207
96	nucleoside salvage (GO:0043174)	3.02234579
97	DNA replication-independent nucleosome organization (GO:0034724)	3.01735028
98	DNA replication-independent nucleosome assembly (GO:0006336)	3.01735028
99	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.01490966
100	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.01490966
101	galactose catabolic process (GO:0019388)	3.01223339
102	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.00202549
103	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.00202549
104	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.00202549
105	guanosine-containing compound biosynthetic process (GO:1901070)	2.99349884
106	nucleobase-containing small molecule interconversion (GO:0015949)	2.99118161
107	proline biosynthetic process (GO:0006561)	2.98840720
108	transcription-coupled nucleotide-excision repair (GO:0006283)	2.98555361
109	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.98305874
110	DNA replication checkpoint (GO:0000076)	2.97914334
111	rRNA methylation (GO:0031167)	2.97114148
112	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.95879348
113	termination of RNA polymerase III transcription (GO:0006386)	2.95879348
114	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.95312353
115	cellular protein complex disassembly (GO:0043624)	2.93945917
116	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.91451971
117	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.91451971
118	nucleotide salvage (GO:0043173)	2.91390975
119	nucleobase biosynthetic process (GO:0046112)	2.91091687
120	telomere maintenance via telomere lengthening (GO:0010833)	2.90565644
121	L-methionine salvage (GO:0071267)	2.89036942
122	L-methionine biosynthetic process (GO:0071265)	2.89036942
123	amino acid salvage (GO:0043102)	2.89036942
124	mitotic recombination (GO:0006312)	2.87335814
125	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.84886289
126	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.84460287
127	purine nucleotide salvage (GO:0032261)	2.84269265
128	L-serine metabolic process (GO:0006563)	2.83111309
129	deoxyribose phosphate biosynthetic process (GO:0046385)	2.82336179
130	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.82336179
131	cellular metabolic compound salvage (GO:0043094)	2.81218636
132	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.76988877
133	rRNA processing (GO:0006364)	2.76244985
134	positive regulation of ligase activity (GO:0051351)	2.74499026
135	deoxyribonucleotide biosynthetic process (GO:0009263)	2.74305877
136	NADPH regeneration (GO:0006740)	2.73886178
137	folic acid transport (GO:0015884)	2.73721583
138	purine nucleobase biosynthetic process (GO:0009113)	2.72993158
139	cellular component biogenesis (GO:0044085)	2.71649635
140	G1/S transition of mitotic cell cycle (GO:0000082)	2.69776547
141	cell cycle G1/S phase transition (GO:0044843)	2.69776547
142	serine family amino acid biosynthetic process (GO:0009070)	2.68640188
143	AMP metabolic process (GO:0046033)	2.68344377
144	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	2.66020818
145	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.65097401
146	rRNA metabolic process (GO:0016072)	2.62895061
147	porphyrin-containing compound biosynthetic process (GO:0006779)	2.62522373
148	ATP synthesis coupled proton transport (GO:0015986)	2.61652652
149	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.61652652
150	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.61460401

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.32255642
2	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	4.25612248
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.51560622
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.92636375
5	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.76443058
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.63034483
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.58782419
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.57897814
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.57398659
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.57221543
11	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.45073837
12	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.42270559
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.37240258
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.28171414
15	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.26039518
16	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.20408207
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.14678527
18	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.06940592
19	DCP1A_22483619_ChIP-Seq_HELA_Human	2.02916377
20	* XRN2_22483619_ChIP-Seq_HELA_Human	2.01793316
21	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.96319180
22	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.91685181
23	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.89055441
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.85665317
25	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.84797600
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.78460870
27	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.77474098
28	GABP_19822575_ChIP-Seq_HepG2_Human	1.77004758
29	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.76388672
30	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.73397535
31	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.72347276
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.72008715
33	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.66865293
34	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.66070629
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.62485582
36	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.61730668
37	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.60459695
38	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.59602342
39	ELK1_19687146_ChIP-ChIP_HELA_Human	1.58140541
40	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.57639517
41	* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.55133670
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.54466189
43	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.52215366
44	* VDR_21846776_ChIP-Seq_THP-1_Human	1.48999986
45	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.47791130
46	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.42946795
47	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.41437437
48	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.39583630
49	MYC_22102868_ChIP-Seq_BL_Human	1.38990188
50	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.37362461
51	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.36381464
52	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.36165168
53	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.35610364
54	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.32846090
55	TTF2_22483619_ChIP-Seq_HELA_Human	1.30826219
56	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.30730292
57	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.29615567
58	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.28190305
59	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27144924
60	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.26702884
61	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.25592061
62	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.25319593
63	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.25295097
64	ZNF263_19887448_ChIP-Seq_K562_Human	1.24778444
65	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.24306842
66	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.24063324
67	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.22158779
68	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.21963662
69	MYC_18940864_ChIP-ChIP_HL60_Human	1.21878252
70	KDM5A_27292631_Chip-Seq_BREAST_Human	1.21076823
71	CIITA_25753668_ChIP-Seq_RAJI_Human	1.20914739
72	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.20007152
73	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.19484375
74	AR_21909140_ChIP-Seq_LNCAP_Human	1.18951762
75	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.18874993
76	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.18405615
77	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.18110173
78	TFEB_21752829_ChIP-Seq_HELA_Human	1.17917343
79	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.14057273
80	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.13639832
81	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.13134376
82	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.12860238
83	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.12696334
84	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.12312059
85	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.12203220
86	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.11792245
87	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.11739450
88	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.10623073
89	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.09012087
90	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.07906502
91	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.05473819
92	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.04987460
93	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.04634315
94	SPI1_23547873_ChIP-Seq_NB4_Human	1.04037369
95	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.03312071
96	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.02717333
97	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.02399773
98	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.02088440
99	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.01537283
100	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.01385669
101	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.01335462
102	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.01304049
103	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.00957762
104	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.00902231
105	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.98798690
106	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.98713297
107	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.97317749
108	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.97316010
109	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.95983617
110	MYB_21317192_ChIP-Seq_ERMYB_Mouse	0.95828806
111	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.95090018
112	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.94994997
113	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.94875916
114	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.94349347
115	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.94183593
116	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.92592403
117	BCL6_27268052_Chip-Seq_Bcells_Human	0.92544743
118	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.92136632
119	ATF3_27146783_Chip-Seq_COLON_Human	0.92110054
120	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.91326102
121	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.89024421
122	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.86810270
123	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.86192253
124	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.83785828
125	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.81052297

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.33294271
2	MP0009840_abnormal_foam_cell	3.57368634
3	MP0003693_abnormal_embryo_hatching	3.40996093
4	MP0003186_abnormal_redox_activity	3.21918062
5	MP0003656_abnormal_erythrocyte_physiolo	2.94335776
6	MP0004957_abnormal_blastocyst_morpholog	2.54356447
7	MP0003123_paternal_imprinting	2.42715079
8	MP0004147_increased_porphyrin_level	2.33717771
9	MP0006292_abnormal_olfactory_placode	2.31346346
10	MP0003111_abnormal_nucleus_morphology	2.26330159
11	MP0000490_abnormal_crypts_of	2.11139902
12	MP0001853_heart_inflammation	2.00247146
13	MP0006054_spinal_hemorrhage	1.96554801
14	MP0006036_abnormal_mitochondrial_physio	1.95951287
15	MP0005670_abnormal_white_adipose	1.95115942
16	MP0009333_abnormal_splenocyte_physiolog	1.92675759
17	MP0003279_aneurysm	1.86925104
18	MP0002396_abnormal_hematopoietic_system	1.85925924
19	MP0001545_abnormal_hematopoietic_system	1.81499427
20	MP0005397_hematopoietic_system_phenotyp	1.81499427
21	MP0010094_abnormal_chromosome_stability	1.80680166
22	MP0005058_abnormal_lysosome_morphology	1.79748176
23	MP0003077_abnormal_cell_cycle	1.78102616
24	MP0009379_abnormal_foot_pigmentation	1.76223739
25	MP0010030_abnormal_orbit_morphology	1.74369661
26	MP0010352_gastrointestinal_tract_polyps	1.74160272
27	MP0003705_abnormal_hypodermis_morpholog	1.72034287
28	MP0001188_hyperpigmentation	1.69255160
29	MP0002938_white_spotting	1.62989241
30	MP0000685_abnormal_immune_system	1.61245824
31	MP0001529_abnormal_vocalization	1.60786136
32	MP0002160_abnormal_reproductive_system	1.55309618
33	MP0005083_abnormal_biliary_tract	1.52593735
34	MP0000358_abnormal_cell_content/	1.51457919
35	MP0005332_abnormal_amino_acid	1.51178584
36	MP0000858_altered_metastatic_potential	1.51075383
37	MP0002163_abnormal_gland_morphology	1.50313940
38	MP0003941_abnormal_skin_development	1.47211404
39	MP0000049_abnormal_middle_ear	1.45480843
40	MP0002139_abnormal_hepatobiliary_system	1.45099626
41	MP0005501_abnormal_skin_physiology	1.42700921
42	MP0008007_abnormal_cellular_replicative	1.39974240
43	MP0008932_abnormal_embryonic_tissue	1.39883088
44	MP0002102_abnormal_ear_morphology	1.38481917
45	MP0005319_abnormal_enzyme/_coenzyme	1.35832705
46	MP0001697_abnormal_embryo_size	1.35750737
47	MP0009643_abnormal_urine_homeostasis	1.34296018
48	MP0002132_abnormal_respiratory_system	1.32998269
49	MP0006035_abnormal_mitochondrial_morpho	1.32976976
50	MP0004133_heterotaxia	1.32728530
51	MP0001293_anophthalmia	1.32678629
52	MP0003315_abnormal_perineum_morphology	1.31599606
53	MP0008789_abnormal_olfactory_epithelium	1.29882072
54	MP0009697_abnormal_copulation	1.28189441
55	MP0002210_abnormal_sex_determination	1.28026514
56	MP0008877_abnormal_DNA_methylation	1.26463048
57	MP0001672_abnormal_embryogenesis/_devel	1.25882901
58	MP0005380_embryogenesis_phenotype	1.25882901
59	MP0003567_abnormal_fetal_cardiomyocyte	1.22725034
60	MP0004233_abnormal_muscle_weight	1.21796695
61	MP0001727_abnormal_embryo_implantation	1.21631921
62	MP0002085_abnormal_embryonic_tissue	1.21569269
63	MP0002736_abnormal_nociception_after	1.21157808
64	MP0008058_abnormal_DNA_repair	1.21121879
65	MP0003119_abnormal_digestive_system	1.20820980
66	MP0000689_abnormal_spleen_morphology	1.20713751
67	MP0003937_abnormal_limbs/digits/tail_de	1.19303888
68	MP0002019_abnormal_tumor_incidence	1.18811790
69	MP0002722_abnormal_immune_system	1.17983522
70	MP0000343_altered_response_to	1.17683282
71	MP0001764_abnormal_homeostasis	1.15281181
72	MP0003191_abnormal_cellular_cholesterol	1.14357326
73	MP0005636_abnormal_mineral_homeostasis	1.14122505
74	MP0000750_abnormal_muscle_regeneration	1.13232170
75	MP0003890_abnormal_embryonic-extraembry	1.12408212
76	MP0005360_urolithiasis	1.12146523
77	MP0003566_abnormal_cell_adhesion	1.11402321
78	MP0003763_abnormal_thymus_physiology	1.10171670
79	MP0005584_abnormal_enzyme/coenzyme_acti	1.09483761
80	MP0009672_abnormal_birth_weight	1.09423680
81	MP0002398_abnormal_bone_marrow	1.08260161
82	MP0005023_abnormal_wound_healing	1.07674999
83	MP0002796_impaired_skin_barrier	1.07350456
84	MP0003786_premature_aging	1.07047709
85	MP0001542_abnormal_bone_strength	1.06250167
86	MP0000372_irregular_coat_pigmentation	1.06234679
87	MP0005671_abnormal_response_to	1.04185261
88	MP0003436_decreased_susceptibility_to	1.03515780
89	MP0008438_abnormal_cutaneous_collagen	1.02983375
90	MP0005075_abnormal_melanosome_morpholog	1.02434221
91	MP0008469_abnormal_protein_level	1.01045470
92	MP0003121_genomic_imprinting	1.00173702
93	MP0002429_abnormal_blood_cell	0.99429063
94	MP0002405_respiratory_system_inflammati	0.98855474
95	MP0000609_abnormal_liver_physiology	0.98776974
96	MP0000313_abnormal_cell_death	0.98706445
97	MP0003984_embryonic_growth_retardation	0.98625823
98	MP0001905_abnormal_dopamine_level	0.97886808
99	MP0005025_abnormal_response_to	0.97573808
100	MP0000598_abnormal_liver_morphology	0.96541480
101	MP0001730_embryonic_growth_arrest	0.96529809
102	MP0005266_abnormal_metabolism	0.96195091
103	MP0002084_abnormal_developmental_patter	0.95819643
104	MP0001145_abnormal_male_reproductive	0.95678529
105	MP0001873_stomach_inflammation	0.95122714
106	MP0003718_maternal_effect	0.94952110
107	MP0001919_abnormal_reproductive_system	0.94873388
108	MP0000350_abnormal_cell_proliferation	0.94336293
109	MP0002089_abnormal_postnatal_growth/wei	0.93617679
110	MP0002088_abnormal_embryonic_growth/wei	0.93108824
111	MP0005389_reproductive_system_phenotype	0.92675846
112	MP0001881_abnormal_mammary_gland	0.92572455
113	MP0001835_abnormal_antigen_presentation	0.92493911
114	MP0001666_abnormal_nutrient_absorption	0.92263520
115	MP0001929_abnormal_gametogenesis	0.92071269
116	MP0002111_abnormal_tail_morphology	0.91424905
117	MP0008995_early_reproductive_senescence	0.90913316
118	MP0000653_abnormal_sex_gland	0.90404745
119	MP0009785_altered_susceptibility_to	0.90072060
120	MP0001346_abnormal_lacrimal_gland	0.89911581
121	MP0005365_abnormal_bile_salt	0.89767187
122	MP0008260_abnormal_autophagy	0.89472414
123	MP0003866_abnormal_defecation	0.88735460
124	MP0003172_abnormal_lysosome_physiology	0.88541851
125	MP0002697_abnormal_eye_size	0.87902878
126	MP0003329_amyloid_beta_deposits	0.87557335
127	MP0001286_abnormal_eye_development	0.86940695
128	MP0002080_prenatal_lethality	0.86443184
129	MP0009250_abnormal_appendicular_skeleto	0.85701264
130	MP0000477_abnormal_intestine_morphology	0.84632200
131	MP0002877_abnormal_melanocyte_morpholog	0.82897805
132	MP0000716_abnormal_immune_system	0.82246477
133	MP0010155_abnormal_intestine_physiology	0.82062636
134	MP0001756_abnormal_urination	0.81876554
135	MP0005394_taste/olfaction_phenotype	0.81429120
136	MP0005499_abnormal_olfactory_system	0.81429120
137	MP0002452_abnormal_antigen_presenting	0.80509464
138	MP0010329_abnormal_lipoprotein_level	0.79851779
139	MP0001845_abnormal_inflammatory_respons	0.79825022
140	MP0005379_endocrine/exocrine_gland_phen	0.79771152
141	MP0002970_abnormal_white_adipose	0.79600356
142	MP0002269_muscular_atrophy	0.78612997
143	MP0000749_muscle_degeneration	0.78583739
144	MP0005464_abnormal_platelet_physiology	0.78229010
145	MP0005376_homeostasis/metabolism_phenot	0.78073860
146	MP0002420_abnormal_adaptive_immunity	0.77086248
147	MP0003724_increased_susceptibility_to	0.76777141
148	MP0001819_abnormal_immune_cell	0.76706342
149	MP0002419_abnormal_innate_immunity	0.76570950
150	MP0004947_skin_inflammation	0.76375924
151	MP0004019_abnormal_vitamin_homeostasis	0.75901790
152	MP0010307_abnormal_tumor_latency	0.75446110
153	MP0002177_abnormal_outer_ear	0.74555138
154	MP0004142_abnormal_muscle_tone	0.74299751
155	MP0005084_abnormal_gallbladder_morpholo	0.73502927
156	MP0005085_abnormal_gallbladder_physiolo	0.72358757
157	MP0000631_abnormal_neuroendocrine_gland	0.70941788
158	MP0005451_abnormal_body_composition	0.68739397
159	MP0008875_abnormal_xenobiotic_pharmacok	0.68636372
160	MP0009053_abnormal_anal_canal	0.68211765
161	MP0005408_hypopigmentation	0.67497798
162	MP0000678_abnormal_parathyroid_gland	0.67432587
163	MP0005395_other_phenotype	0.66059053
164	MP0000537_abnormal_urethra_morphology	0.65625908
165	MP0005257_abnormal_intraocular_pressure	0.65550029
166	MP0003861_abnormal_nervous_system	0.65446186
167	MP0003698_abnormal_male_reproductive	0.65398483
168	MP0006072_abnormal_retinal_apoptosis	0.64816993
169	MP0003936_abnormal_reproductive_system	0.63844065
170	MP0002161_abnormal_fertility/fecundity	0.63650389
171	MP0003942_abnormal_urinary_system	0.63007467
172	MP0003136_yellow_coat_color	0.60296497
173	MP0002233_abnormal_nose_morphology	0.59369209
174	MP0000015_abnormal_ear_pigmentation	0.59211995
175	MP0005330_cardiomyopathy	0.59168548

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of cells of the erythroid lineage (HP:0012130)	4.98179640
2	Abnormal number of erythroid precursors (HP:0012131)	4.84828780
3	Progressive macrocephaly (HP:0004481)	4.23460315
4	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.08267734
5	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.08267734
6	Abnormality of the heme biosynthetic pathway (HP:0010472)	4.02347699
7	Increased serum pyruvate (HP:0003542)	3.68406818
8	Abnormality of glycolysis (HP:0004366)	3.59387931
9	Hepatic necrosis (HP:0002605)	3.58681822
10	Hepatocellular necrosis (HP:0001404)	3.47657032
11	Microretrognathia (HP:0000308)	3.19991467
12	Reticulocytopenia (HP:0001896)	3.07017961
13	Renal Fanconi syndrome (HP:0001994)	2.99001382
14	Increased serum ferritin (HP:0003281)	2.98734224
15	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.98003227
16	Petechiae (HP:0000967)	2.95010961
17	Progressive muscle weakness (HP:0003323)	2.90766244
18	Selective tooth agenesis (HP:0001592)	2.77146711
19	Aplastic anemia (HP:0001915)	2.76556911
20	Birth length less than 3rd percentile (HP:0003561)	2.75437997
21	Breast hypoplasia (HP:0003187)	2.74200702
22	Vertebral compression fractures (HP:0002953)	2.72665822
23	Pallor (HP:0000980)	2.71011721
24	Vacuolated lymphocytes (HP:0001922)	2.70585884
25	Macrocytic anemia (HP:0001972)	2.68432923
26	Generalized aminoaciduria (HP:0002909)	2.65681004
27	Increased serum lactate (HP:0002151)	2.63756804
28	Methylmalonic aciduria (HP:0012120)	2.62291393
29	Oral leukoplakia (HP:0002745)	2.60095804
30	Poor head control (HP:0002421)	2.59601062
31	Mitochondrial inheritance (HP:0001427)	2.59129376
32	Type I transferrin isoform profile (HP:0003642)	2.58127006
33	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.56148192
34	Increased muscle lipid content (HP:0009058)	2.55590431
35	Rough bone trabeculation (HP:0100670)	2.54244501
36	Dicarboxylic aciduria (HP:0003215)	2.52950874
37	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.52950874
38	Nausea (HP:0002018)	2.51961251
39	Lactic acidosis (HP:0003128)	2.48226219
40	Testicular atrophy (HP:0000029)	2.46415638
41	Increased intramyocellular lipid droplets (HP:0012240)	2.45142587
42	Multiple enchondromatosis (HP:0005701)	2.43912981
43	Mesangial abnormality (HP:0001966)	2.43197245
44	Leukodystrophy (HP:0002415)	2.42647744
45	Nonimmune hydrops fetalis (HP:0001790)	2.41495119
46	Cerebral hypomyelination (HP:0006808)	2.39043848
47	Abnormality of iron homeostasis (HP:0011031)	2.38425452
48	Increased CSF lactate (HP:0002490)	2.36756784
49	Hypoplasia of the pons (HP:0012110)	2.36750526
50	Chromsome breakage (HP:0040012)	2.35407170
51	Abnormal mitochondria in muscle tissue (HP:0008316)	2.33099004
52	Horseshoe kidney (HP:0000085)	2.33095348
53	Abnormality of the pons (HP:0007361)	2.32397931
54	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.31439843
55	Microvesicular hepatic steatosis (HP:0001414)	2.28803752
56	Abnormality of the labia minora (HP:0012880)	2.28251933
57	Abnormal number of incisors (HP:0011064)	2.28214422
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.27816518
59	Abnormality of alanine metabolism (HP:0010916)	2.27816518
60	Hyperalaninemia (HP:0003348)	2.27816518
61	Biconcave vertebral bodies (HP:0004586)	2.27613042
62	CNS demyelination (HP:0007305)	2.25309487
63	Abnormal protein glycosylation (HP:0012346)	2.25014969
64	Abnormal glycosylation (HP:0012345)	2.25014969
65	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.25014969
66	Abnormal protein N-linked glycosylation (HP:0012347)	2.25014969
67	Respiratory difficulties (HP:0002880)	2.24478020
68	Optic disc pallor (HP:0000543)	2.22135842
69	Abnormality of transition element cation homeostasis (HP:0011030)	2.21841398
70	Trismus (HP:0000211)	2.20058011
71	Pancytopenia (HP:0001876)	2.18079298
72	Acute encephalopathy (HP:0006846)	2.17965687
73	Acute necrotizing encephalopathy (HP:0006965)	2.15973375
74	Abnormality of reticulocytes (HP:0004312)	2.15716185
75	IgM deficiency (HP:0002850)	2.14132300
76	Abnormality of fatty-acid metabolism (HP:0004359)	2.12190426
77	Reduced antithrombin III activity (HP:0001976)	2.11965420
78	Dysostosis multiplex (HP:0000943)	2.11374866
79	Exertional dyspnea (HP:0002875)	2.09781955
80	Colon cancer (HP:0003003)	2.09613623
81	Abnormality of the anterior horn cell (HP:0006802)	2.07558974
82	Degeneration of anterior horn cells (HP:0002398)	2.07558974
83	Sparse eyelashes (HP:0000653)	2.07232331
84	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.06966497
85	Methylmalonic acidemia (HP:0002912)	2.06738847
86	Respiratory failure (HP:0002878)	2.05430408
87	Hyperglycinuria (HP:0003108)	2.05123423
88	Cleft eyelid (HP:0000625)	2.03211451
89	Lipid accumulation in hepatocytes (HP:0006561)	2.02768556
90	Pustule (HP:0200039)	2.02636625
91	Megaloblastic anemia (HP:0001889)	2.02194042
92	Hyperglycinemia (HP:0002154)	2.01463608
93	Hypoplastic pelvis (HP:0008839)	1.99725529
94	Lethargy (HP:0001254)	1.99672115
95	Absent thumb (HP:0009777)	1.97996075
96	Opisthotonus (HP:0002179)	1.97954035
97	Abnormal hemoglobin (HP:0011902)	1.96276534
98	Hyperammonemia (HP:0001987)	1.95802849
99	Spastic paraparesis (HP:0002313)	1.95520709
100	X-linked dominant inheritance (HP:0001423)	1.95291172
101	Abnormality of the umbilical cord (HP:0010881)	1.95112280
102	Elevated erythrocyte sedimentation rate (HP:0003565)	1.94843762
103	Carpal bone hypoplasia (HP:0001498)	1.94538238
104	Abnormal trabecular bone morphology (HP:0100671)	1.91135937
105	Exercise intolerance (HP:0003546)	1.91061546
106	Prolonged neonatal jaundice (HP:0006579)	1.90444188
107	Emotional lability (HP:0000712)	1.89780226
108	Pendular nystagmus (HP:0012043)	1.89777334
109	Death in infancy (HP:0001522)	1.89254164
110	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.88600961
111	Ragged-red muscle fibers (HP:0003200)	1.88383289
112	Hyperbilirubinemia (HP:0002904)	1.88309171
113	Facial cleft (HP:0002006)	1.87998302
114	Meckel diverticulum (HP:0002245)	1.87042036
115	Beaking of vertebral bodies (HP:0004568)	1.86183829
116	Aplasia/Hypoplasia of the patella (HP:0006498)	1.85844835
117	Increased hepatocellular lipid droplets (HP:0006565)	1.85753237
118	Thrombocytosis (HP:0001894)	1.83292354
119	Abnormal lung lobation (HP:0002101)	1.83098798
120	Abnormality of the preputium (HP:0100587)	1.81702105
121	Microcytic anemia (HP:0001935)	1.80915209
122	Abnormality of serum amino acid levels (HP:0003112)	1.80247198
123	Posterior subcapsular cataract (HP:0007787)	1.79747143
124	Abnormal cartilage morphology (HP:0002763)	1.79190305
125	Premature ovarian failure (HP:0008209)	1.78594512
126	3-Methylglutaconic aciduria (HP:0003535)	1.77918350
127	Rhabdomyolysis (HP:0003201)	1.77461395
128	Hypokinesia (HP:0002375)	1.76911839
129	Joint stiffness (HP:0001387)	1.76862172
130	Urinary glycosaminoglycan excretion (HP:0003541)	1.76467890
131	Mucopolysacchariduria (HP:0008155)	1.76467890
132	Ileus (HP:0002595)	1.76464112
133	Abnormality of placental membranes (HP:0011409)	1.75889703
134	Amniotic constriction ring (HP:0009775)	1.75889703
135	Protrusio acetabuli (HP:0003179)	1.75613177
136	Secondary amenorrhea (HP:0000869)	1.75415367
137	Breech presentation (HP:0001623)	1.74010005
138	Cerebral edema (HP:0002181)	1.73911585
139	Abnormality of glycine metabolism (HP:0010895)	1.72759777
140	Abnormality of methionine metabolism (HP:0010901)	1.70969190
141	Abnormality of the ileum (HP:0001549)	1.69886854
142	Adrenal hypoplasia (HP:0000835)	1.67678905
143	Proximal placement of thumb (HP:0009623)	1.67320228
144	Patellar aplasia (HP:0006443)	1.66609814
145	Poor suck (HP:0002033)	1.65596810
146	Abnormal pupillary function (HP:0007686)	1.64973832

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	4.50818817
2	BUB1	3.79574165
3	VRK2	3.59320993
4	TESK2	3.25885792
5	PIM2	3.23997781
6	STK16	2.96994635
7	BCKDK	2.77383391
8	ACVR1B	2.77377362
9	WEE1	2.63023684
10	TRIB3	2.43471272
11	EIF2AK1	2.30261933
12	MAP3K11	2.20688034
13	ERN1	2.18169831
14	KDR	2.17248554
15	SCYL2	1.96540481
16	TSSK6	1.91020149
17	PDK2	1.87158812
18	LRRK2	1.79737595
19	TESK1	1.75168527
20	MAPKAPK3	1.74325336
21	PLK3	1.64888885
22	EIF2AK3	1.57564234
23	EPHA2	1.55991068
24	RPS6KB2	1.55734580
25	PKN2	1.53403536
26	TAF1	1.51317819
27	RPS6KA4	1.47834115
28	ILK	1.47345530
29	TAOK3	1.44200079
30	PNCK	1.43226264
31	VRK1	1.38686696
32	CSNK1G3	1.35810185
33	MAP4K1	1.34940136
34	DYRK3	1.30489629
35	NEK1	1.28755989
36	FLT3	1.24464328
37	SMG1	1.22694713
38	MAP2K3	1.22170882
39	ARAF	1.21374468
40	CHEK2	1.19572384
41	TLK1	1.18706701
42	PAK4	1.18554248
43	BRSK2	1.18224037
44	NUAK1	1.14182243
45	TBK1	1.13498285
46	MAP3K8	1.11382945
47	MAP2K2	1.06111892
48	STK10	1.05802890
49	CSNK1G1	1.05660721
50	CSNK1G2	1.05524812
51	MST4	1.05426739
52	ZAP70	1.04465583
53	IRAK3	1.04423284
54	CDK7	1.02356633
55	NEK2	1.01798565
56	AURKA	0.99813189
57	CSNK1A1L	0.95059339
58	EEF2K	0.94277027
59	CDC7	0.93635168
60	TYK2	0.93487218
61	ABL2	0.93321009
62	TAOK2	0.90499437
63	CDK19	0.90281508
64	PLK1	0.89653869
65	BRAF	0.86564781
66	BRSK1	0.85883866
67	PIM1	0.85298796
68	GRK6	0.83077073
69	PLK4	0.82539015
70	AURKB	0.80900539
71	MUSK	0.80690149
72	BLK	0.78464176
73	CLK1	0.77763403
74	ZAK	0.77270255
75	MINK1	0.77232705
76	MAP2K7	0.77229591
77	PAK1	0.77154199
78	TRIM28	0.76597645
79	CHEK1	0.75513091
80	TTK	0.70379191
81	MAP3K3	0.69553742
82	TGFBR1	0.68943150
83	MATK	0.67813874
84	KIT	0.67537359
85	LIMK1	0.65778320
86	MYLK	0.65632497
87	EIF2AK2	0.63314762
88	NME1	0.63192332
89	JAK3	0.62703337
90	TNIK	0.60370019
91	BTK	0.60205523
92	TAOK1	0.58709864
93	GRK1	0.56012920
94	CDK9	0.55982879
95	PHKG2	0.55858173
96	PHKG1	0.55858173
97	PBK	0.54835189
98	CSNK1E	0.54615458
99	CDK4	0.54524403
100	ATM	0.53856472
101	DAPK1	0.53643509
102	SIK1	0.53075559
103	PRKCI	0.53067337
104	MKNK2	0.51962237
105	LMTK2	0.51625718
106	ALK	0.50683478
107	ERBB4	0.50370409
108	IKBKB	0.48762307
109	ATR	0.48194407
110	PRKG2	0.46353157
111	CSNK2A1	0.46325312
112	MAP2K6	0.46258988
113	DAPK3	0.44559846
114	AKT2	0.44347341
115	ICK	0.43702882
116	CDK2	0.43361642
117	MAPK11	0.43054173
118	CDK1	0.41896711
119	MAPKAPK5	0.41437304
120	CDK8	0.41329678
121	CCNB1	0.41100250
122	CAMKK2	0.39465055
123	STK4	0.39059919
124	MAPK4	0.38806780
125	MAP3K12	0.37706811
126	MAP3K10	0.36967289
127	PRKCG	0.36861216
128	DYRK2	0.36456319
129	TGFBR2	0.36030004
130	RPS6KA5	0.35763334
131	CSNK2A2	0.35016036
132	MAPKAPK2	0.34606696
133	MAP3K5	0.34537016
134	CDK14	0.33647231
135	PIK3CG	0.32595539
136	MAP2K1	0.31835539
137	PINK1	0.31426637
138	SRPK1	0.30456124
139	NEK9	0.29704373
140	MST1R	0.28129592
141	MAP4K2	0.27501828
142	CSNK1A1	0.26267562
143	CAMK2G	0.23627535
144	CDK11A	0.23184541

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	4.03425489
2	Ribosome_Homo sapiens_hsa03010	3.83273155
3	Proteasome_Homo sapiens_hsa03050	3.69051232
4	Mismatch repair_Homo sapiens_hsa03430	2.74549030
5	Sulfur relay system_Homo sapiens_hsa04122	2.61247998
6	RNA polymerase_Homo sapiens_hsa03020	2.53330647
7	Pyrimidine metabolism_Homo sapiens_hsa00240	2.40427893
8	Folate biosynthesis_Homo sapiens_hsa00790	2.40216770
9	Base excision repair_Homo sapiens_hsa03410	2.28369494
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.91418334
11	Pentose phosphate pathway_Homo sapiens_hsa00030	1.85450216
12	Homologous recombination_Homo sapiens_hsa03440	1.83791701
13	One carbon pool by folate_Homo sapiens_hsa00670	1.79208812
14	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.76657759
15	Parkinsons disease_Homo sapiens_hsa05012	1.72468906
16	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.70979663
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.68481903
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.67707195
19	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.66186018
20	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.64266391
21	Spliceosome_Homo sapiens_hsa03040	1.61323785
22	Caffeine metabolism_Homo sapiens_hsa00232	1.60025475
23	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.57772393
24	Protein export_Homo sapiens_hsa03060	1.44194546
25	Glutathione metabolism_Homo sapiens_hsa00480	1.42043713
26	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.39094238
27	Carbon metabolism_Homo sapiens_hsa01200	1.38162492
28	RNA transport_Homo sapiens_hsa03013	1.35422444
29	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.34938178
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.32779898
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.30134858
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.28089098
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.27618199
34	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.25565296
35	Cell cycle_Homo sapiens_hsa04110	1.23110009
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.22123977
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.19590179
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.19467956
39	Huntingtons disease_Homo sapiens_hsa05016	1.16313301
40	p53 signaling pathway_Homo sapiens_hsa04115	1.13960374
41	Galactose metabolism_Homo sapiens_hsa00052	1.10711693
42	Fatty acid degradation_Homo sapiens_hsa00071	1.09492640
43	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.04935625
44	Purine metabolism_Homo sapiens_hsa00230	1.03696575
45	Other glycan degradation_Homo sapiens_hsa00511	1.03618292
46	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.01690520
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.98889906
48	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.96334997
49	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.94770736
50	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.91162855
51	Arginine and proline metabolism_Homo sapiens_hsa00330	0.87005417
52	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.84375299
53	Propanoate metabolism_Homo sapiens_hsa00640	0.84359885
54	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.83330154
55	Pyruvate metabolism_Homo sapiens_hsa00620	0.81701107
56	mRNA surveillance pathway_Homo sapiens_hsa03015	0.81652099
57	Alzheimers disease_Homo sapiens_hsa05010	0.80526761
58	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.78926981
59	Metabolic pathways_Homo sapiens_hsa01100	0.78351876
60	Fatty acid metabolism_Homo sapiens_hsa01212	0.75152630
61	Lysosome_Homo sapiens_hsa04142	0.71952814
62	* Peroxisome_Homo sapiens_hsa04146	0.71621748
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.71349636
64	Sulfur metabolism_Homo sapiens_hsa00920	0.70085338
65	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.67683196
66	Fanconi anemia pathway_Homo sapiens_hsa03460	0.65677353
67	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.60667368
68	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.60594542
69	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.59932507
70	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.57457240
71	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.55470086
72	Vibrio cholerae infection_Homo sapiens_hsa05110	0.55010843
73	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.54792667
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.53558657
75	Oocyte meiosis_Homo sapiens_hsa04114	0.53314650
76	Apoptosis_Homo sapiens_hsa04210	0.53126634
77	RNA degradation_Homo sapiens_hsa03018	0.52123332
78	Legionellosis_Homo sapiens_hsa05134	0.52057730
79	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51357236
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.50094950
81	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.49385849
82	Shigellosis_Homo sapiens_hsa05131	0.48972751
83	Renin-angiotensin system_Homo sapiens_hsa04614	0.48608053
84	Thyroid cancer_Homo sapiens_hsa05216	0.46761059
85	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.45368716
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45219938
87	PPAR signaling pathway_Homo sapiens_hsa03320	0.41972210
88	Regulation of autophagy_Homo sapiens_hsa04140	0.40999304
89	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.39741553
90	Antigen processing and presentation_Homo sapiens_hsa04612	0.39407008
91	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.37737849
92	Steroid biosynthesis_Homo sapiens_hsa00100	0.37481139
93	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.36959807
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.36150590
95	Chemical carcinogenesis_Homo sapiens_hsa05204	0.35515132
96	Acute myeloid leukemia_Homo sapiens_hsa05221	0.35431205
97	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.35290746
98	Fatty acid elongation_Homo sapiens_hsa00062	0.34968457
99	Bladder cancer_Homo sapiens_hsa05219	0.34584050
100	Non-homologous end-joining_Homo sapiens_hsa03450	0.34330369
101	Herpes simplex infection_Homo sapiens_hsa05168	0.33499138
102	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.33468465
103	Basal transcription factors_Homo sapiens_hsa03022	0.33468280
104	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.33342310
105	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32660189
106	Viral carcinogenesis_Homo sapiens_hsa05203	0.31770200
107	Glycerolipid metabolism_Homo sapiens_hsa00561	0.30184928
108	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.29834536
109	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.28215416
110	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.26642613
111	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.26380096
112	Basal cell carcinoma_Homo sapiens_hsa05217	0.26188107
113	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.24563003
114	Arginine biosynthesis_Homo sapiens_hsa00220	0.23770392
115	Tyrosine metabolism_Homo sapiens_hsa00350	0.22258211
116	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.21418818
117	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.20842283
118	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.19970780
119	Hippo signaling pathway_Homo sapiens_hsa04390	0.19953150
120	Butanoate metabolism_Homo sapiens_hsa00650	0.19124528
121	Phenylalanine metabolism_Homo sapiens_hsa00360	0.17432112
122	Tryptophan metabolism_Homo sapiens_hsa00380	0.14850096
123	Wnt signaling pathway_Homo sapiens_hsa04310	0.10285833
124	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.06657195
125	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.05858779

MPV17L2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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