MPZL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.85565090
2cell adhesion mediated by integrin (GO:0033627)4.81896782
3cellular response to hepatocyte growth factor stimulus (GO:0035729)4.60343820
4response to hepatocyte growth factor (GO:0035728)4.60343820
5skin morphogenesis (GO:0043589)4.54476019
6collagen fibril organization (GO:0030199)4.15380717
7endodermal cell differentiation (GO:0035987)4.13604145
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.93325883
9desmosome organization (GO:0002934)3.91536511
10dermatan sulfate biosynthetic process (GO:0030208)3.82154207
11protein retention in ER lumen (GO:0006621)3.78813026
12myelination in peripheral nervous system (GO:0022011)3.74236795
13peripheral nervous system axon ensheathment (GO:0032292)3.74236795
14mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.67049123
15protein localization to endosome (GO:0036010)3.65951507
16regulation of cardioblast differentiation (GO:0051890)3.65564492
17polarized epithelial cell differentiation (GO:0030859)3.61214815
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.59158651
19retina vasculature morphogenesis in camera-type eye (GO:0061299)3.57725157
20establishment of epithelial cell polarity (GO:0090162)3.55751725
21axon extension involved in axon guidance (GO:0048846)3.55032685
22neuron projection extension involved in neuron projection guidance (GO:1902284)3.55032685
23substrate-dependent cell migration (GO:0006929)3.52522652
24positive regulation of actin filament depolymerization (GO:0030836)3.52121042
25positive regulation of catenin import into nucleus (GO:0035413)3.48417089
26collagen metabolic process (GO:0032963)3.43823446
27vascular endothelial growth factor signaling pathway (GO:0038084)3.43575422
28respiratory tube development (GO:0030323)3.43423202
29semaphorin-plexin signaling pathway (GO:0071526)3.41660676
30peptidyl-proline hydroxylation (GO:0019511)3.41435175
31negative regulation of axon extension involved in axon guidance (GO:0048843)3.38933600
32dermatan sulfate metabolic process (GO:0030205)3.38569241
33planar cell polarity pathway involved in neural tube closure (GO:0090179)3.37205712
34collagen catabolic process (GO:0030574)3.36280990
35multicellular organismal macromolecule metabolic process (GO:0044259)3.35269095
36negative regulation of keratinocyte proliferation (GO:0010839)3.35176814
37dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.31568988
38epithelial cell-cell adhesion (GO:0090136)3.27027761
39protein heterotrimerization (GO:0070208)3.26368889
40regulation of cell proliferation involved in kidney development (GO:1901722)3.25373888
41negative regulation of axon guidance (GO:1902668)3.23821693
42regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.23698810
43extracellular matrix disassembly (GO:0022617)3.23471544
44lymph vessel development (GO:0001945)3.18516448
45multicellular organismal metabolic process (GO:0044236)3.16675421
46cell-substrate junction assembly (GO:0007044)3.15897870
47multicellular organismal catabolic process (GO:0044243)3.15539811
48mesenchymal cell proliferation (GO:0010463)3.14873530
49wound healing, spreading of epidermal cells (GO:0035313)3.14413155
50bundle of His cell to Purkinje myocyte communication (GO:0086069)3.09293136
51regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.09202203
52cell proliferation involved in kidney development (GO:0072111)3.07100787
53regulation of transforming growth factor beta2 production (GO:0032909)3.06134640
54mesodermal cell differentiation (GO:0048333)3.05960602
55cell migration involved in heart development (GO:0060973)3.05126455
56endothelial tube morphogenesis (GO:0061154)3.05100523
57morphogenesis of an endothelium (GO:0003159)3.05100523
58type B pancreatic cell proliferation (GO:0044342)3.02556371
59paraxial mesoderm development (GO:0048339)3.02437198
60renal system development (GO:0072001)3.00659557
61COPII vesicle coating (GO:0048208)3.00222831
62sequestering of extracellular ligand from receptor (GO:0035581)2.99135503
63midgut development (GO:0007494)2.98852683
64myelination (GO:0042552)2.97972558
65vesicle coating (GO:0006901)2.96939923
66heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.96677487
67bone trabecula formation (GO:0060346)2.96099030
68retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.95715266
69negative regulation of myoblast differentiation (GO:0045662)2.94114642
70protein hydroxylation (GO:0018126)2.93558419
71Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.93418650
72regulation of glomerulus development (GO:0090192)2.92721350
73axon ensheathment (GO:0008366)2.92239163
74ensheathment of neurons (GO:0007272)2.92239163
75organ formation (GO:0048645)2.90437557
76pattern specification involved in kidney development (GO:0061004)2.89605073
77cell migration involved in sprouting angiogenesis (GO:0002042)2.87937820
78regulation of establishment of planar polarity (GO:0090175)2.87100843
79lens fiber cell development (GO:0070307)2.86698310
80kidney mesenchyme development (GO:0072074)2.86271131
81activated T cell proliferation (GO:0050798)2.85909531
82metanephric mesenchyme development (GO:0072075)2.84475695
83barbed-end actin filament capping (GO:0051016)2.83114963
84chondrocyte development (GO:0002063)2.82509219
85enteric nervous system development (GO:0048484)2.82309347
86extracellular fibril organization (GO:0043206)2.81018745
87positive regulation of vasculogenesis (GO:2001214)2.80860975
88eye photoreceptor cell differentiation (GO:0001754)2.78824452
89photoreceptor cell differentiation (GO:0046530)2.78824452
90keratan sulfate catabolic process (GO:0042340)2.78669633
91positive regulation of osteoblast proliferation (GO:0033690)2.77679141
92regulation of early endosome to late endosome transport (GO:2000641)2.77480162
93negative regulation of chondrocyte differentiation (GO:0032331)2.77061646
94gap junction assembly (GO:0016264)2.77009839
95regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.75568271
96regulation of catenin import into nucleus (GO:0035412)2.75465703
97lung morphogenesis (GO:0060425)2.75363641
98epithelial tube branching involved in lung morphogenesis (GO:0060441)2.74623380
99chondrocyte proliferation (GO:0035988)2.74567763
100positive regulation of endothelial cell apoptotic process (GO:2000353)2.72278891
101positive regulation of neurological system process (GO:0031646)2.71369345
102central nervous system myelination (GO:0022010)2.71333268
103axon ensheathment in central nervous system (GO:0032291)2.71333268
104notochord development (GO:0030903)2.70885763
105regulation of SMAD protein import into nucleus (GO:0060390)2.70382198
106endothelium development (GO:0003158)2.70019810
107apoptotic cell clearance (GO:0043277)2.68325392
108limb bud formation (GO:0060174)2.68320310
109stress fiber assembly (GO:0043149)2.67815581
110extracellular matrix assembly (GO:0085029)2.66661333
111mesenchyme morphogenesis (GO:0072132)2.66535816
112L-serine transport (GO:0015825)2.66222857
113negative regulation of cartilage development (GO:0061037)2.66094203
114mesenchymal cell differentiation involved in kidney development (GO:0072161)2.63707430
115mesenchymal cell differentiation involved in renal system development (GO:2001012)2.63707430
116basement membrane organization (GO:0071711)2.63622884
117atrioventricular valve morphogenesis (GO:0003181)2.63000864
118substrate adhesion-dependent cell spreading (GO:0034446)2.62406718
119cellular copper ion homeostasis (GO:0006878)2.61374506
120hippo signaling (GO:0035329)2.61257982
121negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.61129815
122wound healing, spreading of cells (GO:0044319)2.60893814
123amino acid import (GO:0043090)2.60760798
124extracellular matrix organization (GO:0030198)2.59436677
125regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.59073163
126embryonic foregut morphogenesis (GO:0048617)2.58422683
127membrane protein ectodomain proteolysis (GO:0006509)2.58408989
128negative regulation of axon extension (GO:0030517)2.58362800
129extracellular structure organization (GO:0043062)2.58256408
130blood vessel maturation (GO:0001955)2.58208523
131negative regulation of stem cell proliferation (GO:2000647)2.58144502
132endocardial cushion morphogenesis (GO:0003203)2.58065560
133epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.57888771
134vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.57538301
135adhesion of symbiont to host (GO:0044406)2.57281315
136mesenchymal to epithelial transition (GO:0060231)2.56057130
137positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.56030739
138endocardial cushion development (GO:0003197)2.55050378
139cell surface receptor signaling pathway involved in heart development (GO:0061311)2.54747190
140glomerular basement membrane development (GO:0032836)2.54667875
141regulation of heart morphogenesis (GO:2000826)2.54017955
142ganglion development (GO:0061548)2.53741091
143negative regulation of catenin import into nucleus (GO:0035414)2.53666477
144outer ear morphogenesis (GO:0042473)2.53400894
145lymphangiogenesis (GO:0001946)2.53214566
146cytoskeletal anchoring at plasma membrane (GO:0007016)2.52699257
147fibril organization (GO:0097435)2.52644223
148adherens junction assembly (GO:0034333)2.51935761
149COPI coating of Golgi vesicle (GO:0048205)2.51903812
150Golgi transport vesicle coating (GO:0048200)2.51903812
151glomerular visceral epithelial cell development (GO:0072015)2.50938309
152adhesion of symbiont to host cell (GO:0044650)2.50492180
153virion attachment to host cell (GO:0019062)2.50492180
154cellular response to vitamin (GO:0071295)2.49596842
155cellular response to vitamin D (GO:0071305)2.49567978
156establishment of planar polarity (GO:0001736)2.48906389
157establishment of tissue polarity (GO:0007164)2.48906389
158regulation of secondary heart field cardioblast proliferation (GO:0003266)2.48855770
159regulation of cardioblast proliferation (GO:0003264)2.48855770
160G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.47692092
161lung-associated mesenchyme development (GO:0060484)2.47582850
162craniofacial suture morphogenesis (GO:0097094)2.45880931
163hindlimb morphogenesis (GO:0035137)2.44830664
164regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.44358562
165regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.41816474
166embryonic skeletal joint morphogenesis (GO:0060272)2.39960797
167regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.38485099
168embryonic hindlimb morphogenesis (GO:0035116)2.37756765
169endothelial cell morphogenesis (GO:0001886)2.35888343
170lateral sprouting from an epithelium (GO:0060601)2.35484882
171endothelial cell proliferation (GO:0001935)2.34843048
172positive regulation of endothelial cell differentiation (GO:0045603)2.34707891
173cell proliferation involved in metanephros development (GO:0072203)2.34252600
174renal filtration (GO:0097205)2.32887114
175regulation of vasculogenesis (GO:2001212)2.32663326
176cranial suture morphogenesis (GO:0060363)2.31604308
177regulation of collateral sprouting (GO:0048670)2.31394977
178negative regulation of vascular permeability (GO:0043116)2.30675216
179regulation of mesenchymal cell proliferation (GO:0010464)2.29710160
180negative regulation of neural precursor cell proliferation (GO:2000178)2.29182155
181glomerulus development (GO:0032835)2.28671368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.50433429
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.36409448
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.19107547
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.19107547
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.19107547
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.18596955
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.13508043
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.74266772
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.71715637
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.65820380
11* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.55021202
12* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.42121076
13* AR_21909140_ChIP-Seq_LNCAP_Human2.39604032
14DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.27037247
15ZNF263_19887448_ChIP-Seq_K562_Human2.19749172
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.18766508
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17530724
18* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.15739230
19CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.12200010
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.03636628
21* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.02621983
22* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.02621983
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00488308
24SOX2_18555785_ChIP-Seq_MESCs_Mouse1.98690773
25* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.94448657
26ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.90150013
27P300_27058665_Chip-Seq_ZR-75-30cells_Human1.90092560
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.88035405
29* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.82037514
30ISL1_27105846_Chip-Seq_CPCs_Mouse1.80634418
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80396737
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.76983104
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.74853432
34SOX9_24532713_ChIP-Seq_HFSC_Mouse1.68595595
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.68246182
36CLOCK_20551151_ChIP-Seq_293T_Human1.65160157
37* ELK3_25401928_ChIP-Seq_HUVEC_Human1.63268423
38* UBF1/2_26484160_Chip-Seq_HMECs_Human1.62401570
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.60465169
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58169522
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57210283
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55963967
43AR_21572438_ChIP-Seq_LNCaP_Human1.55484617
44* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54154143
45SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53938160
46* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53055353
47* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51586615
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.49615600
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.49500989
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49367302
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.47481822
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45670074
53ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.44648793
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.44308634
55NRF2_20460467_ChIP-Seq_MEFs_Mouse1.44308634
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43488853
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41659487
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.40696043
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38846582
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38525546
61TP53_18474530_ChIP-ChIP_U2OS_Human1.37874564
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.37154291
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.36167413
64OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.34566646
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.33908960
66* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.33643570
67* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33640682
68SOX17_20123909_ChIP-Seq_XEN_Mouse1.33296215
69* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33136567
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31080968
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31080968
72EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.29628425
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29098368
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.27667972
75NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.27443806
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.26970109
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.26145454
78SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23565518
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.22928092
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21577830
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21438000
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21377657
83BRD4_25478319_ChIP-Seq_HGPS_Human1.20213001
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19883404
85* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.19283263
86* RACK7_27058665_Chip-Seq_MCF-7_Human1.18957151
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18764682
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.17540437
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.17393264
90ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17192986
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.17167495
92* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.15365307
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15304949
94CDX2_20551321_ChIP-Seq_CACO-2_Human1.15161226
95* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14984496
96ATF3_27146783_Chip-Seq_COLON_Human1.13125348
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12694975
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12432536
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.12058997
100* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11142926
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10685350
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.09626615
103* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.09392067
104SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09380138
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08624896
106* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08493711
107NANOG_16153702_ChIP-ChIP_HESCs_Human1.07396001
108KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07293943
109TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05501448
110SOX2_20726797_ChIP-Seq_SW620_Human1.04620716
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04454057
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04210815
113* TBX20_22328084_ChIP-Seq_HEART_Mouse1.03477177
114* TBX20_22080862_ChIP-Seq_HEART_Mouse1.03477177
115* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03205342
116GF1B_26923725_Chip-Seq_HPCs_Mouse1.03189119
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03015201
118PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02970981
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01902745
120WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01091533
121RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00804538
122ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00426329
123* EOMES_21245162_ChIP-Seq_HESCs_Human1.00255622
124SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00178708
125CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99765119
126TP53_22127205_ChIP-Seq_IMR90_Human0.99685393
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99374250
128EZH2_27294783_Chip-Seq_ESCs_Mouse0.99209430
129JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99198408
130CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98393598
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98247627
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97840538
133* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.97619467
134CJUN_26792858_Chip-Seq_BT549_Human0.97604762
135CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97042752
136JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96770071
137SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95960763
138PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95509071
139NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95434428
140* TCF4_18268006_ChIP-ChIP_LS174T_Human0.94675577
141* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93710183
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.93156095
143* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92813997
144SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92234829
145PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91883718
146P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91583973
147Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91132069
148E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91059747
149AHR_22903824_ChIP-Seq_MCF-7_Human0.90866287
150NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89656069
151NANOG_21062744_ChIP-ChIP_HESCs_Human0.89227114
152NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89005539
153SA1_22415368_ChIP-Seq_MEFs_Mouse0.89001920
154* KDM2B_26808549_Chip-Seq_K562_Human0.88997625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane3.22693327
2MP0005171_absent_coat_pigmentation3.14682792
3MP0003122_maternal_imprinting3.04882611
4MP0003566_abnormal_cell_adhesion3.00884409
5MP0010352_gastrointestinal_tract_polyps2.59271607
6MP0003385_abnormal_body_wall2.39222251
7MP0008438_abnormal_cutaneous_collagen2.35885149
8MP0005503_abnormal_tendon_morphology2.31355337
9MP0000537_abnormal_urethra_morphology2.30748618
10MP0010030_abnormal_orbit_morphology2.27577397
11MP0005623_abnormal_meninges_morphology2.18983199
12MP0001958_emphysema2.18270834
13MP0002938_white_spotting2.18257023
14MP0004134_abnormal_chest_morphology2.14431819
15MP0010234_abnormal_vibrissa_follicle2.13724108
16MP0001879_abnormal_lymphatic_vessel2.12317554
17MP0010368_abnormal_lymphatic_system2.04840954
18MP0005023_abnormal_wound_healing1.98963311
19MP0003121_genomic_imprinting1.96917059
20MP0005257_abnormal_intraocular_pressure1.93294817
21MP0003937_abnormal_limbs/digits/tail_de1.91745512
22MP0003123_paternal_imprinting1.89988891
23MP0003942_abnormal_urinary_system1.88085573
24MP0000462_abnormal_digestive_system1.87586961
25MP0003091_abnormal_cell_migration1.87424187
26MP0004858_abnormal_nervous_system1.83442843
27MP0006054_spinal_hemorrhage1.82856236
28MP0002060_abnormal_skin_morphology1.82791210
29MP0002282_abnormal_trachea_morphology1.79914057
30MP0000566_synostosis1.77858991
31MP0009250_abnormal_appendicular_skeleto1.77814762
32MP0003119_abnormal_digestive_system1.77232220
33MP0003136_yellow_coat_color1.75281017
34MP0001849_ear_inflammation1.71468898
35MP0005367_renal/urinary_system_phenotyp1.70490305
36MP0000516_abnormal_urinary_system1.70490305
37MP0000534_abnormal_ureter_morphology1.66169776
38MP0003115_abnormal_respiratory_system1.60408340
39MP0000762_abnormal_tongue_morphology1.57285330
40MP0000049_abnormal_middle_ear1.53787449
41MP0002249_abnormal_larynx_morphology1.53016190
42MP0000579_abnormal_nail_morphology1.50855301
43MP0003283_abnormal_digestive_organ1.48393397
44MP0005167_abnormal_blood-brain_barrier1.47858946
45MP0002877_abnormal_melanocyte_morpholog1.42733408
46MP0005508_abnormal_skeleton_morphology1.38322106
47MP0003950_abnormal_plasma_membrane1.38231118
48MP0002295_abnormal_pulmonary_circulatio1.37903199
49MP0002932_abnormal_joint_morphology1.35916157
50MP0003705_abnormal_hypodermis_morpholog1.35640958
51MP0002796_impaired_skin_barrier1.34361684
52MP0005408_hypopigmentation1.34295053
53MP0004885_abnormal_endolymph1.28153077
54MP0003453_abnormal_keratinocyte_physiol1.27054376
55MP0000778_abnormal_nervous_system1.25737718
56MP0003935_abnormal_craniofacial_develop1.24836508
57MP0003567_abnormal_fetal_cardiomyocyte1.24242291
58MP0005409_darkened_coat_color1.23923239
59MP0005197_abnormal_uvea_morphology1.23907733
60MP0004133_heterotaxia1.19843988
61MP0003755_abnormal_palate_morphology1.19486108
62MP0002116_abnormal_craniofacial_bone1.18390844
63MP0001542_abnormal_bone_strength1.17007510
64MP0005248_abnormal_Harderian_gland1.16315512
65MP0000467_abnormal_esophagus_morphology1.16034719
66MP0001299_abnormal_eye_distance/1.15052571
67MP0009053_abnormal_anal_canal1.14887960
68MP0000372_irregular_coat_pigmentation1.14696278
69MP0005058_abnormal_lysosome_morphology1.13353714
70MP0003315_abnormal_perineum_morphology1.13256725
71MP0001915_intracranial_hemorrhage1.13183858
72MP0000678_abnormal_parathyroid_gland1.12224365
73MP0009697_abnormal_copulation1.11957939
74MP0000428_abnormal_craniofacial_morphol1.10181678
75MP0002089_abnormal_postnatal_growth/wei1.09948789
76MP0001243_abnormal_dermal_layer1.09731245
77MP0005076_abnormal_cell_differentiation1.09587068
78MP0000733_abnormal_muscle_development1.09520480
79MP0002254_reproductive_system_inflammat1.09227669
80MP0003300_gastrointestinal_ulcer1.07672897
81MP0003890_abnormal_embryonic-extraembry1.07273645
82MP0002653_abnormal_ependyma_morphology1.06409483
83MP0000163_abnormal_cartilage_morphology1.06111685
84MP0002084_abnormal_developmental_patter1.05794548
85MP0002233_abnormal_nose_morphology1.04785533
86MP0004197_abnormal_fetal_growth/weight/1.04046378
87MP0002085_abnormal_embryonic_tissue1.03393692
88MP0002111_abnormal_tail_morphology1.03262700
89MP0004264_abnormal_extraembryonic_tissu1.03003091
90MP0005501_abnormal_skin_physiology1.02796066
91MP0001293_anophthalmia1.02674769
92MP0000432_abnormal_head_morphology1.02317907
93MP0004233_abnormal_muscle_weight1.01563610
94MP0001485_abnormal_pinna_reflex0.99349239
95MP0002751_abnormal_autonomic_nervous0.98862282
96MP0003938_abnormal_ear_development0.98492076
97MP0009384_cardiac_valve_regurgitation0.98110690
98MP0002925_abnormal_cardiovascular_devel0.97523164
99MP0003279_aneurysm0.97071465
100MP0002092_abnormal_eye_morphology0.96799651
101MP0005275_abnormal_skin_tensile0.95561416
102MP0001216_abnormal_epidermal_layer0.94888061
103MP0001286_abnormal_eye_development0.92578813
104MP0008932_abnormal_embryonic_tissue0.92002844
105MP0002109_abnormal_limb_morphology0.91075391
106MP0000767_abnormal_smooth_muscle0.90978772
107MP0000383_abnormal_hair_follicle0.90894115
108MP0002127_abnormal_cardiovascular_syste0.90362495
109MP0002896_abnormal_bone_mineralization0.90206374
110MP0010678_abnormal_skin_adnexa0.88972173
111MP0003861_abnormal_nervous_system0.88904528
112MP0005193_abnormal_anterior_eye0.87819362
113MP0003878_abnormal_ear_physiology0.87684406
114MP0005377_hearing/vestibular/ear_phenot0.87684406
115MP0002108_abnormal_muscle_morphology0.87540408
116MP0002697_abnormal_eye_size0.87312625
117MP0001697_abnormal_embryo_size0.86574618
118MP0003941_abnormal_skin_development0.86458332
119MP0003448_altered_tumor_morphology0.84879175
120MP0002098_abnormal_vibrissa_morphology0.84394429
121MP0002177_abnormal_outer_ear0.84196825
122MP0005187_abnormal_penis_morphology0.84104386
123MP0009840_abnormal_foam_cell0.83332506
124MP0003984_embryonic_growth_retardation0.82454602
125MP0000631_abnormal_neuroendocrine_gland0.82414613
126MP0002088_abnormal_embryonic_growth/wei0.81782949
127MP0002114_abnormal_axial_skeleton0.81509109
128MP0001672_abnormal_embryogenesis/_devel0.80158229
129MP0005380_embryogenesis_phenotype0.80158229
130MP0001614_abnormal_blood_vessel0.80017143
131MP0002102_abnormal_ear_morphology0.78892953
132MP0001730_embryonic_growth_arrest0.78730110
133MP0005451_abnormal_body_composition0.78329138
134MP0005595_abnormal_vascular_smooth0.77885615
135MP0002086_abnormal_extraembryonic_tissu0.77453700
136MP0003191_abnormal_cellular_cholesterol0.76293639
137MP0010771_integument_phenotype0.76219059
138MP0008260_abnormal_autophagy0.74189188
139MP0000377_abnormal_hair_follicle0.74159650
140MP0003221_abnormal_cardiomyocyte_apopto0.72461128
141MP0005164_abnormal_response_to0.70700841
142MP0002113_abnormal_skeleton_development0.68553336
143MP0004782_abnormal_surfactant_physiolog0.68180361
144MP0003329_amyloid_beta_deposits0.68133310
145MP0005390_skeleton_phenotype0.67832257

Predicted human phenotypes

RankGene SetZ-score
1Aortic dissection (HP:0002647)3.80073300
2Fragile skin (HP:0001030)3.35122204
3Vertebral compression fractures (HP:0002953)3.18526852
4Epiphyseal dysplasia (HP:0002656)3.12367949
5Wormian bones (HP:0002645)2.96695368
6Abnormality of dentin (HP:0010299)2.90406291
7Aortic aneurysm (HP:0004942)2.89126703
8Protrusio acetabuli (HP:0003179)2.82716458
9White forelock (HP:0002211)2.77806433
10Genu recurvatum (HP:0002816)2.71483371
11Esophageal atresia (HP:0002032)2.69681083
12Abnormality of the parathyroid morphology (HP:0011766)2.67601974
13Right ventricular cardiomyopathy (HP:0011663)2.63139966
14Short 4th metacarpal (HP:0010044)2.61648658
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.61648658
16Osteolytic defects of the phalanges of the hand (HP:0009771)2.58655862
17Osteolytic defects of the hand bones (HP:0009699)2.58655862
18Short nail (HP:0001799)2.51816802
19Adrenal hypoplasia (HP:0000835)2.51203325
20Ulnar bowing (HP:0003031)2.46796042
21Patchy hypopigmentation of hair (HP:0011365)2.46556966
22Cerebral aneurysm (HP:0004944)2.46441532
23Small epiphyses (HP:0010585)2.44207067
24Hepatoblastoma (HP:0002884)2.43306162
25Premature skin wrinkling (HP:0100678)2.43156109
26Dilatation of the ascending aorta (HP:0005111)2.42853863
27Broad metatarsal (HP:0001783)2.38103186
28Hyperextensible skin (HP:0000974)2.37933816
29Alacrima (HP:0000522)2.34874715
30Natal tooth (HP:0000695)2.34777283
31Shallow orbits (HP:0000586)2.33846071
32Mitral valve prolapse (HP:0001634)2.32195341
33Coronal craniosynostosis (HP:0004440)2.31843786
34Abnormality of the acetabulum (HP:0003170)2.27835135
35Premature rupture of membranes (HP:0001788)2.26651634
36Joint laxity (HP:0001388)2.25679639
37Ankyloglossia (HP:0010296)2.25625094
38Peritonitis (HP:0002586)2.21861233
39Hypoplastic pelvis (HP:0008839)2.19329295
40Absent frontal sinuses (HP:0002688)2.16558139
41Diastasis recti (HP:0001540)2.12860372
42Lymphangioma (HP:0100764)2.12468248
43Anophthalmia (HP:0000528)2.09615197
44Abnormal delivery (HP:0001787)2.08647001
45Bowel diverticulosis (HP:0005222)2.07797635
46Disproportionate tall stature (HP:0001519)2.06883200
47Vascular tortuosity (HP:0004948)2.05863531
48Renal duplication (HP:0000075)2.04601277
49Cortical dysplasia (HP:0002539)2.04274690
50Spondylolisthesis (HP:0003302)2.04226519
51Thin bony cortex (HP:0002753)2.03726799
52Abnormality of carpal bone ossification (HP:0006257)2.03207422
53Breech presentation (HP:0001623)2.01731496
54Heterochromia iridis (HP:0001100)2.00831870
55Arterial tortuosity (HP:0005116)1.99839731
56Gastrointestinal atresia (HP:0002589)1.99652340
57Cupped ribs (HP:0000887)1.99451968
58Deep palmar crease (HP:0006191)1.99067905
59Abnormality of the fetal cardiovascular system (HP:0010948)1.98256825
60Abnormal umbilical cord blood vessels (HP:0011403)1.98256825
61Single umbilical artery (HP:0001195)1.98256825
62Biconcave vertebral bodies (HP:0004586)1.97634618
63Ankle contracture (HP:0006466)1.96663768
64Intestinal atresia (HP:0011100)1.95205269
65Mild short stature (HP:0003502)1.94873868
66Asymmetry of the thorax (HP:0001555)1.94216649
67Abnormality of the distal phalanges of the toes (HP:0010182)1.93635968
68Absent hand (HP:0004050)1.93196366
69Scapular winging (HP:0003691)1.92820833
70Midline defect of the nose (HP:0004122)1.92781275
71Abnormality of oral frenula (HP:0000190)1.92508381
72Abnormal pancreas size (HP:0012094)1.92492177
73Aneurysm (HP:0002617)1.92438675
74Mitral stenosis (HP:0001718)1.89771524
75Congenital glaucoma (HP:0001087)1.87532529
76Advanced eruption of teeth (HP:0006288)1.86933679
77Abnormality of the 4th metacarpal (HP:0010012)1.86198306
78Elbow flexion contracture (HP:0002987)1.85692058
79Alopecia of scalp (HP:0002293)1.85389561
80Overgrowth (HP:0001548)1.85034890
81Cerebral hypomyelination (HP:0006808)1.84610812
82Hypoplasia of the iris (HP:0007676)1.84603133
83Bladder diverticulum (HP:0000015)1.84045945
84Broad ribs (HP:0000885)1.83493138
85Abnormal ossification of hand bones (HP:0005921)1.82887840
86Vertebral hypoplasia (HP:0008417)1.82806398
87Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.82806398
88Decreased lacrimation (HP:0000633)1.81624548
89Delayed epiphyseal ossification (HP:0002663)1.79390135
90Inguinal hernia (HP:0000023)1.78825292
91Exostoses (HP:0100777)1.78718228
92Morphological abnormality of the inner ear (HP:0011390)1.78495038
93Soft skin (HP:0000977)1.77815687
94Coxa vara (HP:0002812)1.77614361
95Ectopia lentis (HP:0001083)1.77181428
96Missing ribs (HP:0000921)1.77036300
97Abnormality of skull ossification (HP:0002703)1.76856892
98Abnormal vertebral ossification (HP:0100569)1.75687174
99Nonimmune hydrops fetalis (HP:0001790)1.75245211
100Wrist flexion contracture (HP:0001239)1.75240785
101Fragile nails (HP:0001808)1.75107348
102Neurofibrillary tangles (HP:0002185)1.75020715
103Mitral regurgitation (HP:0001653)1.74841335
104Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.73738542
105Renal hypoplasia (HP:0000089)1.73518540
106Tibial bowing (HP:0002982)1.72823763
107Supernumerary ribs (HP:0005815)1.72380173
108Upper limb amyotrophy (HP:0009129)1.71578122
109Distal upper limb amyotrophy (HP:0007149)1.71578122
110Atrophic scars (HP:0001075)1.70916064
111Mildly elevated creatine phosphokinase (HP:0008180)1.69458195
112Delayed cranial suture closure (HP:0000270)1.68242986
113Rhizomelia (HP:0008905)1.67558491
114Cutaneous finger syndactyly (HP:0010554)1.67405270
115Onycholysis (HP:0001806)1.66452945
116Slender build (HP:0001533)1.65524864
117Back pain (HP:0003418)1.65369059
118Abnormality of the distal phalanx of the thumb (HP:0009617)1.65351910
119Stenosis of the external auditory canal (HP:0000402)1.65278699
120Wide anterior fontanel (HP:0000260)1.64995802
121Hemivertebrae (HP:0002937)1.64157909
122Femoral bowing (HP:0002980)1.63604935
123Spinal cord lesions (HP:0100561)1.63494797
124Syringomyelia (HP:0003396)1.63494797
125Preaxial foot polydactyly (HP:0001841)1.63120901
126Partial duplication of the phalanx of hand (HP:0009999)1.62998220
127Neonatal short-limb short stature (HP:0008921)1.62971461
128Abnormal lung lobation (HP:0002101)1.62426902
129Protruding ear (HP:0000411)1.62234457
130Osteoarthritis (HP:0002758)1.62071114
131Vitreoretinal degeneration (HP:0000655)1.62025503
132Hypoplastic left heart (HP:0004383)1.61701547
133Down-sloping shoulders (HP:0200021)1.60398206
134Cervical subluxation (HP:0003308)1.58978000
135Ovoid vertebral bodies (HP:0003300)1.58346024
136Skull defect (HP:0001362)1.58136759
137Hand muscle atrophy (HP:0009130)1.57966141
138Glossoptosis (HP:0000162)1.57879488
139Flat acetabular roof (HP:0003180)1.57406026
140Neoplasm of the oral cavity (HP:0100649)1.57401239
141Deviation of the hallux (HP:0010051)1.57030542
142Aplasia/Hypoplasia involving the musculature (HP:0001460)1.56983826
143Hallux valgus (HP:0001822)1.56130459
144Decreased skull ossification (HP:0004331)1.55892155
145Abnormality of the pulmonary veins (HP:0011718)1.55655824
146Termporal pattern (HP:0011008)1.55618890
147Insidious onset (HP:0003587)1.55618890
148Midface retrusion (HP:0011800)1.55285250
149Hypoplastic ischia (HP:0003175)1.54982382
150Pterygium (HP:0001059)1.54147042
151Prominent occiput (HP:0000269)1.53464983
152Spinal rigidity (HP:0003306)1.53368788
153Sprengel anomaly (HP:0000912)1.53334039
154Irregular epiphyses (HP:0010582)1.53144724
155Cutaneous syndactyly (HP:0012725)1.53100956
156Flared iliac wings (HP:0002869)1.53085425
157Supernumerary bones of the axial skeleton (HP:0009144)1.52903781
158Blue sclerae (HP:0000592)1.52154012
159Anteriorly placed anus (HP:0001545)1.51448063
160Embryonal renal neoplasm (HP:0011794)1.50771535
161Broad long bones (HP:0005622)1.50675065
162Broad toe (HP:0001837)1.49908314
163Selective tooth agenesis (HP:0001592)1.49421571
164Flat face (HP:0012368)1.48920872
165Broad phalanx (HP:0006009)1.48500506
166Abnormal hand bone ossification (HP:0010660)1.48365016
167Adactyly (HP:0009776)1.48109281
168Partial duplication of thumb phalanx (HP:0009944)1.47376195
169Mixed hearing impairment (HP:0000410)1.47156064
170Germ cell neoplasia (HP:0100728)1.46757148
171Abnormality of the parietal bone (HP:0002696)1.46430158
172Follicular hyperkeratosis (HP:0007502)1.45377495
173Microglossia (HP:0000171)1.44829192
174Congenital malformation of the right heart (HP:0011723)1.43959539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYRO34.37425124
2RIPK12.82556484
3EPHB12.68363787
4TIE12.59879494
5TNIK2.36984347
6PTK22.24916973
7DDR22.24414197
8KDR2.18138769
9LATS12.16551053
10STK392.14167932
11MST1R2.10067620
12LIMK12.00583197
13EPHA21.97333395
14MET1.95634479
15BCR1.92320203
16PKN21.88451543
17EPHB21.88042277
18MAPK131.82833336
19ERN11.79313378
20PAK41.76347062
21IRAK11.71377577
22MYLK1.70231242
23IRAK21.68025393
24PASK1.64898838
25DYRK21.63388729
26TGFBR11.61471258
27ERBB41.60440204
28IRAK31.57826610
29PTK61.57736748
30LATS21.52853925
31PDGFRB1.52267361
32FER1.51963339
33UHMK11.48306963
34ICK1.47964203
35PDGFRA1.45871778
36PRKD31.44595024
37PBK1.40829559
38ERBB31.39436382
39PAK31.27243155
40PIM21.25177613
41FES1.24711237
42MKNK11.24349888
43PRPF4B1.23934441
44ROCK11.21530874
45MAP2K21.17406392
46CDK81.15390755
47ROCK21.15177139
48MAP3K31.15026482
49WNK41.13679002
50NEK91.12381553
51FGFR11.10888300
52TTN1.10734645
53SIK31.08377488
54MOS1.08034490
55EEF2K1.06621441
56BUB11.05278047
57NUAK11.01296836
58ARAF1.00023665
59MST40.99107067
60NLK0.96985915
61BRD40.94399786
62TRIB30.93983770
63STK380.93400314
64TESK10.90827252
65TRIM280.88938986
66CHEK20.87206781
67KSR20.86799302
68SRPK10.86513165
69MAP3K20.85409941
70FGFR40.84748155
71MAP3K60.83516825
72FGFR20.83371858
73CDC42BPA0.82510177
74CSNK1A1L0.81962043
75WNK30.80261502
76NME20.79998481
77RPS6KB20.79837330
78MAPK150.78963602
79PLK40.76620763
80CDK70.76164319
81MELK0.74948264
82PAK20.74085109
83PRKG20.73799309
84ABL20.73793652
85CSNK1G30.72502012
86ERBB20.71489309
87LMTK20.70697967
88CDK60.70221121
89EPHA30.69790428
90STK38L0.69132546
91PRKD20.68956951
92GSK3A0.68645154
93PKN10.68306384
94NEK10.64908522
95NTRK10.63788130
96SIK10.62273388
97OXSR10.62003208
98EIF2AK10.60824979
99PLK20.60668317
100STK100.58023810
101MAP3K120.57678872
102STK30.57585721
103MAP3K80.57552613
104CSNK1G10.57493176
105KSR10.54076138
106FLT30.53366984
107MARK10.51444621
108PLK30.51094900
109PTK2B0.50921548
110TTK0.50908179
111NEK60.50149212
112MTOR0.49653728
113CDK120.48602797
114CSK0.48441443
115DYRK30.47070752
116FGR0.46991874
117RPS6KA20.46269358
118DMPK0.46221246
119CDK180.45930688
120ILK0.45442712
121TSSK60.44743365
122* INSR0.44443539
123RET0.43883995
124CAMK1G0.43672800
125AKT30.41983494
126CDK140.41681649
127CLK10.41034229
128PRKCE0.40342225
129AURKA0.39858810
130CDK150.39628042
131TAOK20.38956500
132PAK10.38001532
133MKNK20.37508895
134TGFBR20.37456740
135LRRK20.36825757
136SCYL20.36101466
137BMX0.36059131
138CSNK1G20.35474462
139GRK10.35469487
140CDK11A0.35387016
141SMG10.34205896
142YES10.33726990
143AKT20.33692951
144* SRC0.31935482

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.61934382
2Basal cell carcinoma_Homo sapiens_hsa052172.61189687
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.43762576
4Axon guidance_Homo sapiens_hsa043602.36553280
5Hedgehog signaling pathway_Homo sapiens_hsa043402.29488184
6ECM-receptor interaction_Homo sapiens_hsa045122.29323735
7Hippo signaling pathway_Homo sapiens_hsa043902.26228560
8Adherens junction_Homo sapiens_hsa045202.22298106
9Protein export_Homo sapiens_hsa030602.07269066
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.06834847
11Focal adhesion_Homo sapiens_hsa045101.93725567
12Tight junction_Homo sapiens_hsa045301.92687621
13TGF-beta signaling pathway_Homo sapiens_hsa043501.87115194
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.84708130
15Ether lipid metabolism_Homo sapiens_hsa005651.83675615
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.81292898
17MicroRNAs in cancer_Homo sapiens_hsa052061.81108980
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.80897904
19Other glycan degradation_Homo sapiens_hsa005111.69556764
20Steroid biosynthesis_Homo sapiens_hsa001001.66194532
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.58673909
22Galactose metabolism_Homo sapiens_hsa000521.51336004
23Proteoglycans in cancer_Homo sapiens_hsa052051.48014439
24Renal cell carcinoma_Homo sapiens_hsa052111.46905144
25* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.42635759
26Cell cycle_Homo sapiens_hsa041101.40281002
27Prostate cancer_Homo sapiens_hsa052151.35272268
28Vibrio cholerae infection_Homo sapiens_hsa051101.33589078
29Colorectal cancer_Homo sapiens_hsa052101.33043828
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.31832314
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.31235854
32Spliceosome_Homo sapiens_hsa030401.31159316
33Small cell lung cancer_Homo sapiens_hsa052221.29668918
34Wnt signaling pathway_Homo sapiens_hsa043101.27805700
35PI3K-Akt signaling pathway_Homo sapiens_hsa041511.27283815
36Sulfur metabolism_Homo sapiens_hsa009201.26985114
37Basal transcription factors_Homo sapiens_hsa030221.22685241
38N-Glycan biosynthesis_Homo sapiens_hsa005101.20307322
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17254428
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16408268
41Lysosome_Homo sapiens_hsa041421.15967965
42RNA polymerase_Homo sapiens_hsa030201.15153479
43Endometrial cancer_Homo sapiens_hsa052131.14205046
44Melanogenesis_Homo sapiens_hsa049161.13799876
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13604983
46Viral myocarditis_Homo sapiens_hsa054161.11891120
47Notch signaling pathway_Homo sapiens_hsa043301.11797989
48Sphingolipid metabolism_Homo sapiens_hsa006001.09298319
49Melanoma_Homo sapiens_hsa052181.08732094
50mRNA surveillance pathway_Homo sapiens_hsa030151.07843443
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07189085
52RNA transport_Homo sapiens_hsa030131.05476290
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.04433414
54Salmonella infection_Homo sapiens_hsa051321.03607040
55Pathways in cancer_Homo sapiens_hsa052001.02701294
56Protein digestion and absorption_Homo sapiens_hsa049740.97573412
57Bladder cancer_Homo sapiens_hsa052190.96670932
58Oocyte meiosis_Homo sapiens_hsa041140.96293365
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96227244
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95783953
61Thyroid cancer_Homo sapiens_hsa052160.94605491
62Fructose and mannose metabolism_Homo sapiens_hsa000510.93372786
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93313350
64Choline metabolism in cancer_Homo sapiens_hsa052310.91695218
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91148088
66Malaria_Homo sapiens_hsa051440.90375139
67Rap1 signaling pathway_Homo sapiens_hsa040150.89941728
68Chronic myeloid leukemia_Homo sapiens_hsa052200.87418661
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85777625
70Gap junction_Homo sapiens_hsa045400.84876776
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80923026
72Shigellosis_Homo sapiens_hsa051310.79072061
73Cholinergic synapse_Homo sapiens_hsa047250.78744022
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78409040
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76594774
76Biosynthesis of amino acids_Homo sapiens_hsa012300.76319626
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76156866
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.75876006
79Long-term depression_Homo sapiens_hsa047300.74941866
80Pancreatic cancer_Homo sapiens_hsa052120.74434147
81Ras signaling pathway_Homo sapiens_hsa040140.73213646
82Ovarian steroidogenesis_Homo sapiens_hsa049130.73077746
83Fatty acid elongation_Homo sapiens_hsa000620.72712638
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71979658
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.70083927
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69710649
87Estrogen signaling pathway_Homo sapiens_hsa049150.69041685
88HTLV-I infection_Homo sapiens_hsa051660.69013154
89Glioma_Homo sapiens_hsa052140.66837847
90Prion diseases_Homo sapiens_hsa050200.66318695
91Pentose phosphate pathway_Homo sapiens_hsa000300.65939606
92Pertussis_Homo sapiens_hsa051330.65073285
93Platelet activation_Homo sapiens_hsa046110.64331789
94Complement and coagulation cascades_Homo sapiens_hsa046100.64260712
95AMPK signaling pathway_Homo sapiens_hsa041520.63575578
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63329318
97TNF signaling pathway_Homo sapiens_hsa046680.62783496
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.62504054
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62300905
100Hepatitis C_Homo sapiens_hsa051600.60025092
101RNA degradation_Homo sapiens_hsa030180.59664143
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59116164
103Glutathione metabolism_Homo sapiens_hsa004800.59104390
104Phagosome_Homo sapiens_hsa041450.56719684
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55652232
106Dilated cardiomyopathy_Homo sapiens_hsa054140.55321965
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54644443
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.54212109
109Base excision repair_Homo sapiens_hsa034100.53301016
110Renin-angiotensin system_Homo sapiens_hsa046140.53167807
111VEGF signaling pathway_Homo sapiens_hsa043700.52688531
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50008955
113HIF-1 signaling pathway_Homo sapiens_hsa040660.49818621
114Carbon metabolism_Homo sapiens_hsa012000.49323632
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47686440
116ErbB signaling pathway_Homo sapiens_hsa040120.47329777
117Insulin signaling pathway_Homo sapiens_hsa049100.46643738
118Glutamatergic synapse_Homo sapiens_hsa047240.46610769
119Hepatitis B_Homo sapiens_hsa051610.46486971
120GnRH signaling pathway_Homo sapiens_hsa049120.46398455
121Amoebiasis_Homo sapiens_hsa051460.44990810
122p53 signaling pathway_Homo sapiens_hsa041150.44497006
123Thyroid hormone synthesis_Homo sapiens_hsa049180.43837697
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42532686
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.42006785
126Endocytosis_Homo sapiens_hsa041440.40467567
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40363722
128Dorso-ventral axis formation_Homo sapiens_hsa043200.39793282
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39755885
130Prolactin signaling pathway_Homo sapiens_hsa049170.38939301
131Apoptosis_Homo sapiens_hsa042100.38064920
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36228707
133Serotonergic synapse_Homo sapiens_hsa047260.35665086
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34832451
135Arachidonic acid metabolism_Homo sapiens_hsa005900.33762392
136Epstein-Barr virus infection_Homo sapiens_hsa051690.33516070

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