MPZL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)7.99348295
2establishment of skin barrier (GO:0061436)7.53034848
3keratinization (GO:0031424)7.35733682
4regulation of water loss via skin (GO:0033561)7.11002196
5chemical homeostasis within a tissue (GO:0048875)6.54278648
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.21089850
7L-phenylalanine catabolic process (GO:0006559)6.21089850
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.03615676
9L-phenylalanine metabolic process (GO:0006558)6.03615676
10keratinocyte proliferation (GO:0043616)5.82393467
11aromatic amino acid family catabolic process (GO:0009074)5.65297887
12multicellular organismal water homeostasis (GO:0050891)5.62405471
13keratinocyte differentiation (GO:0030216)5.45328101
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.36961444
15kynurenine metabolic process (GO:0070189)5.25651725
16indole-containing compound catabolic process (GO:0042436)5.24783764
17indolalkylamine catabolic process (GO:0046218)5.24783764
18tryptophan catabolic process (GO:0006569)5.24783764
19sulfur amino acid catabolic process (GO:0000098)5.15542400
20urea cycle (GO:0000050)5.10635816
21urea metabolic process (GO:0019627)5.10635816
22cysteine metabolic process (GO:0006534)4.94203904
23bile acid biosynthetic process (GO:0006699)4.93785771
24negative regulation of complement activation (GO:0045916)4.93129638
25high-density lipoprotein particle remodeling (GO:0034375)4.91674857
26tryptophan metabolic process (GO:0006568)4.91247185
27glyoxylate metabolic process (GO:0046487)4.90755014
28water homeostasis (GO:0030104)4.84501973
29serine family amino acid catabolic process (GO:0009071)4.81766772
30negative regulation of fibrinolysis (GO:0051918)4.74753179
31peptide cross-linking (GO:0018149)4.73951183
32nitrogen cycle metabolic process (GO:0071941)4.61895654
33negative regulation of protein activation cascade (GO:2000258)4.61492715
34peptidyl-glutamic acid carboxylation (GO:0017187)4.60550522
35protein carboxylation (GO:0018214)4.60550522
36amino-acid betaine metabolic process (GO:0006577)4.58373974
37regulation of protein activation cascade (GO:2000257)4.57159076
38gap junction assembly (GO:0016264)4.55529993
39regulation of fibrinolysis (GO:0051917)4.54593394
40homocysteine metabolic process (GO:0050667)4.47076773
41glycine metabolic process (GO:0006544)4.40549158
42alpha-linolenic acid metabolic process (GO:0036109)4.37014591
43reverse cholesterol transport (GO:0043691)4.32957615
44complement activation, alternative pathway (GO:0006957)4.31387868
45negative regulation of humoral immune response (GO:0002921)4.31294393
46regulation of triglyceride catabolic process (GO:0010896)4.30916003
47bile acid metabolic process (GO:0008206)4.30424643
48regulation of complement activation (GO:0030449)4.28771899
49negative regulation of keratinocyte proliferation (GO:0010839)4.27911781
50hemidesmosome assembly (GO:0031581)4.27834098
51phospholipid efflux (GO:0033700)4.24875263
52skin morphogenesis (GO:0043589)4.19576702
53negative regulation of sterol transport (GO:0032372)4.17151954
54negative regulation of cholesterol transport (GO:0032375)4.17151954
55epidermal cell differentiation (GO:0009913)4.16850137
56regulation of cholesterol esterification (GO:0010872)4.15167984
57aromatic amino acid family metabolic process (GO:0009072)4.15068503
58cellular glucuronidation (GO:0052695)4.10388800
59desmosome organization (GO:0002934)4.09712660
60plasma lipoprotein particle remodeling (GO:0034369)4.05117650
61protein-lipid complex remodeling (GO:0034368)4.05117650
62macromolecular complex remodeling (GO:0034367)4.05117650
63dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.03935605
64cell adhesion mediated by integrin (GO:0033627)4.03722522
65triglyceride homeostasis (GO:0070328)4.02848706
66acylglycerol homeostasis (GO:0055090)4.02848706
67serine family amino acid metabolic process (GO:0009069)4.00871348
68bundle of His cell to Purkinje myocyte communication (GO:0086069)4.00460404
69lysine metabolic process (GO:0006553)3.96827708
70lysine catabolic process (GO:0006554)3.96827708
71imidazole-containing compound metabolic process (GO:0052803)3.96708325
72negative regulation of lipase activity (GO:0060192)3.96097199
73regulation of cholesterol homeostasis (GO:2000188)3.94957776
74alpha-amino acid catabolic process (GO:1901606)3.92863884
75epidermis development (GO:0008544)3.92083991
76fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.90582506
77intestinal epithelial cell development (GO:0060576)3.89549428
78ethanol oxidation (GO:0006069)3.89495487
79fibrinolysis (GO:0042730)3.85456117
80bile acid and bile salt transport (GO:0015721)3.81942415
81serine family amino acid biosynthetic process (GO:0009070)3.79471332
82tyrosine metabolic process (GO:0006570)3.78921665
83regulation of bile acid biosynthetic process (GO:0070857)3.77994096
84hair cycle (GO:0042633)3.73339879
85molting cycle (GO:0042303)3.73339879
86establishment of tissue polarity (GO:0007164)3.71047830
87establishment of planar polarity (GO:0001736)3.71047830
88plasma lipoprotein particle clearance (GO:0034381)3.68108748
89benzene-containing compound metabolic process (GO:0042537)3.65835246
90cellular amino acid catabolic process (GO:0009063)3.64612431
91cellular biogenic amine catabolic process (GO:0042402)3.64551784
92amine catabolic process (GO:0009310)3.64551784
93glucuronate metabolic process (GO:0019585)3.63974825
94uronic acid metabolic process (GO:0006063)3.63974825
95Golgi transport vesicle coating (GO:0048200)3.62687107
96COPI coating of Golgi vesicle (GO:0048205)3.62687107
97drug catabolic process (GO:0042737)3.59904397
98primary alcohol catabolic process (GO:0034310)3.59592342
99protein localization to endosome (GO:0036010)3.56429025
100carnitine metabolic process (GO:0009437)3.54710294
101indolalkylamine metabolic process (GO:0006586)3.54524809
102hypotonic response (GO:0006971)3.53694394
103response to nitrosative stress (GO:0051409)3.51786056
104phospholipid homeostasis (GO:0055091)3.51708524
105cholesterol efflux (GO:0033344)3.50624101
106cell-substrate junction assembly (GO:0007044)3.50400995
107ethanol metabolic process (GO:0006067)3.50200318
108cholesterol homeostasis (GO:0042632)3.50016216
109xenobiotic catabolic process (GO:0042178)3.48308710
110cellular modified amino acid catabolic process (GO:0042219)3.47806146
111sterol homeostasis (GO:0055092)3.45148086
112iron ion import (GO:0097286)3.44907967
113negative regulation of fatty acid biosynthetic process (GO:0045717)3.43216652
114glutamate metabolic process (GO:0006536)3.41402583
115keratinocyte development (GO:0003334)3.38043173
116flavonoid metabolic process (GO:0009812)3.37803953
117positive regulation of lipoprotein lipase activity (GO:0051006)3.36543473
118positive regulation of triglyceride lipase activity (GO:0061365)3.36543473
119arginine metabolic process (GO:0006525)3.35864437
120plasma lipoprotein particle assembly (GO:0034377)3.35290395
121cellular ketone body metabolic process (GO:0046950)3.34441662
122regulation of keratinocyte proliferation (GO:0010837)3.30246131
123diterpenoid biosynthetic process (GO:0016102)3.28653569
124intestinal cholesterol absorption (GO:0030299)3.28413260
125very-low-density lipoprotein particle assembly (GO:0034379)3.25116129
126lipoprotein metabolic process (GO:0042157)3.24323154
127epoxygenase P450 pathway (GO:0019373)3.23727276
128carboxylic acid catabolic process (GO:0046395)3.23105793
129organic acid catabolic process (GO:0016054)3.23105793
130positive regulation of lipid catabolic process (GO:0050996)3.22919080
131regulation of keratinocyte differentiation (GO:0045616)3.21227823
132aldehyde catabolic process (GO:0046185)3.19588435
133coenzyme catabolic process (GO:0009109)3.14270450
134epithelial cell differentiation involved in prostate gland development (GO:0060742)3.12930287
135positive regulation of epidermal cell differentiation (GO:0045606)3.12587731
136regulation of transforming growth factor beta1 production (GO:0032908)3.10871609
137drug metabolic process (GO:0017144)3.10719263
138interferon-gamma secretion (GO:0072643)3.10310719
139membrane raft organization (GO:0031579)3.07366273
140intermediate filament organization (GO:0045109)3.04979230
141cellular response to vitamin D (GO:0071305)3.04622890
142regulation of transforming growth factor beta production (GO:0071634)2.94004860
143complement activation, classical pathway (GO:0006958)2.90955159
144endothelial cell chemotaxis (GO:0035767)2.73769292
145ectoderm development (GO:0007398)2.73562145
146regulation of transforming growth factor beta2 production (GO:0032909)2.72399408
147membrane budding (GO:0006900)2.72372478
148retinal metabolic process (GO:0042574)2.71129176
149complement activation (GO:0006956)2.70151002
150positive regulation of keratinocyte differentiation (GO:0045618)2.69439796
151regulation of metalloenzyme activity (GO:0048552)2.67737736
152protein autoprocessing (GO:0016540)2.67374502
153positive regulation of epidermis development (GO:0045684)2.65908316
154positive regulation of transforming growth factor beta production (GO:0071636)2.65361140
155renal filtration (GO:0097205)2.64729742
156epithelial cell-cell adhesion (GO:0090136)2.64023577
157sphingomyelin metabolic process (GO:0006684)2.62826156
158ventricular cardiac muscle cell action potential (GO:0086005)2.58682309
159one-carbon compound transport (GO:0019755)2.56965984
160O-glycan processing (GO:0016266)2.56653480
161sphingoid metabolic process (GO:0046519)2.56228491
162lung lobe morphogenesis (GO:0060463)2.54396920
163sphingosine metabolic process (GO:0006670)2.50990351
164protein activation cascade (GO:0072376)2.50920536
165lipoxygenase pathway (GO:0019372)2.50864300
166substrate-dependent cell migration (GO:0006929)2.48036972
167response to vitamin D (GO:0033280)2.46682818
168detection of bacterium (GO:0016045)2.46593934
169regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.45815967
170wound healing (GO:0042060)2.45739818
171phosphate ion transmembrane transport (GO:0035435)2.42084605
172negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.42022833
173diol metabolic process (GO:0034311)2.40936443
174polarized epithelial cell differentiation (GO:0030859)2.37655071
175COPII vesicle coating (GO:0048208)2.37467436
176calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.36463585
177detection of other organism (GO:0098543)2.36275622
178regulation of humoral immune response (GO:0002920)2.29596538
179positive regulation of Cdc42 GTPase activity (GO:0043089)2.29512660
180regulation of epidermis development (GO:0045682)2.26501709
181cell-cell junction assembly (GO:0007043)2.26251786
182regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.25069882
183renal absorption (GO:0070293)2.24042688
184regulation of chemokine secretion (GO:0090196)2.23274687
185hepatocyte differentiation (GO:0070365)2.22647696
186mesenchymal-epithelial cell signaling (GO:0060638)2.22478965
187terpenoid biosynthetic process (GO:0016114)2.21236869
188regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.18688593
189ganglion development (GO:0061548)2.18598631
190glomerular filtration (GO:0003094)2.18203340

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.68299994
2TP63_17297297_ChIP-ChIP_HaCaT_Human8.46569197
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.16922462
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.60752057
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.02163714
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.75778419
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.25708105
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.11495950
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.78939150
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.78385940
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.05917668
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.73104573
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.12766406
14GATA2_21666600_ChIP-Seq_HMVEC_Human2.12730266
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.09849857
16ZNF263_19887448_ChIP-Seq_K562_Human2.01448126
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.87090696
18CLOCK_20551151_ChIP-Seq_293T_Human1.84534279
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84374193
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83854975
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.81387433
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.80787842
23AHR_22903824_ChIP-Seq_MCF-7_Human1.79406976
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.77852705
25CJUN_26792858_Chip-Seq_BT549_Human1.77676295
26* TP63_23658742_ChIP-Seq_EP156T_Human1.77534043
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77165328
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75077692
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.72140026
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66488987
31GATA4_25053715_ChIP-Seq_YYC3_Human1.64952343
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.64276153
33FOXM1_26456572_ChIP-Seq_MCF-7_Human1.58858547
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.55551009
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53528964
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.49076656
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46256474
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44093010
39CDX2_20551321_ChIP-Seq_CACO-2_Human1.43532838
40GATA6_25053715_ChIP-Seq_YYC3_Human1.37883990
41TCF3_18692474_ChIP-Seq_MEFs_Mouse1.37486181
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.36971386
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35099152
44AR_21909140_ChIP-Seq_LNCAP_Human1.33303858
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.32315514
46KLF5_25053715_ChIP-Seq_YYC3_Human1.31588191
47TP53_18474530_ChIP-ChIP_U2OS_Human1.31290040
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30839239
49* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29551239
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28597486
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27279880
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20078949
53* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18240563
54* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18240563
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16288890
56FOXA2_19822575_ChIP-Seq_HepG2_Human1.16208950
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15791648
58ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15273676
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.14919083
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14257681
61NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14068529
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13485979
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12278227
64* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11823092
65HNF4A_19822575_ChIP-Seq_HepG2_Human1.11808816
66* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10755740
67NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10696580
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09240372
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09240372
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09240372
71JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07383597
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06151302
73CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06001320
74SOX2_20726797_ChIP-Seq_SW620_Human1.05294437
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04147138
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03842241
77ATF3_27146783_Chip-Seq_COLON_Human1.03577464
78GATA3_24758297_ChIP-Seq_MCF-7_Human1.03452315
79NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03348631
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03348631
81RACK7_27058665_Chip-Seq_MCF-7_Human1.02295121
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02243903
83TBX20_22328084_ChIP-Seq_HEART_Mouse1.01847765
84TBX20_22080862_ChIP-Seq_HEART_Mouse1.01847765
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01759027
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01573546
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01326220
88SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98783535
89NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95486967
90UBF1/2_26484160_Chip-Seq_HMECs_Human0.95335620
91GATA1_22025678_ChIP-Seq_K562_Human0.94657045
92BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94611666
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94373959
94RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93829174
95TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92272871
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91968079
97ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91184959
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90343952
99TP63_22573176_ChIP-Seq_HFKS_Human0.88633424
100EP300_21415370_ChIP-Seq_HL-1_Mouse0.86482079
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85788920
102OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85677779
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85507582
104CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85007399
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84449686
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.83092502
107TP53_16413492_ChIP-PET_HCT116_Human0.81996834
108STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.81640236
109RUNX1_27514584_Chip-Seq_MCF-7_Human0.79785027
110EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79770894
111HTT_18923047_ChIP-ChIP_STHdh_Human0.78733408
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78378527
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77474396
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77209068
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76877868
116RXR_22108803_ChIP-Seq_LS180_Human0.76664594
117SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.76130687
118SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.75764295
119NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.73853795
120CDX2_22108803_ChIP-Seq_LS180_Human0.73517448
121PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.72467719
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.71585114
123IRF8_27001747_Chip-Seq_BMDM_Mouse0.71441260
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.71268083
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70872206
126ELF5_23300383_ChIP-Seq_T47D_Human0.70836665
127POU5F1_16518401_ChIP-PET_MESCs_Mouse0.70150938
128* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.70035703
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.66887085
130ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.66160189
131NANOG_18692474_ChIP-Seq_MESCs_Mouse0.65662732
132CEBPB_22108803_ChIP-Seq_LS180_Human0.65374967
133ZNF217_24962896_ChIP-Seq_MCF-7_Human0.64654972
134NANOG_16518401_ChIP-PET_MESCs_Mouse0.63006271
135RARA_24833708_ChIP-Seq_LIVER_Mouse0.59509885
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.58276886
137NANOG_18555785_ChIP-Seq_MESCs_Mouse0.57482127
138RARB_24833708_ChIP-Seq_LIVER_Mouse0.55634257
139SOX2_18692474_ChIP-Seq_MESCs_Mouse0.55118602
140KAP1_22055183_ChIP-Seq_ESCs_Mouse0.54997213
141HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.54482224
142FOXA1_25552417_ChIP-Seq_VCAP_Human0.53575950
143SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.53415627
144MYC_18555785_ChIP-Seq_MESCs_Mouse0.53167632
145* CHD1_26751641_Chip-Seq_LNCaP_Human0.52835361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.12393798
2MP0005360_urolithiasis5.66815545
3MP0005085_abnormal_gallbladder_physiolo5.18381762
4MP0005365_abnormal_bile_salt4.66658122
5MP0008875_abnormal_xenobiotic_pharmacok4.16780385
6MP0003806_abnormal_nucleotide_metabolis3.66256556
7MP0010234_abnormal_vibrissa_follicle3.34601312
8MP0002254_reproductive_system_inflammat2.92774338
9MP0002796_impaired_skin_barrier2.92463232
10MP0003252_abnormal_bile_duct2.90520778
11MP0010329_abnormal_lipoprotein_level2.70637801
12MP0009840_abnormal_foam_cell2.63470103
13MP0001666_abnormal_nutrient_absorption2.38438839
14MP0004019_abnormal_vitamin_homeostasis2.33537199
15MP0005083_abnormal_biliary_tract2.20166115
16MP0003195_calcinosis2.13875118
17MP0003705_abnormal_hypodermis_morpholog2.06790886
18MP0005332_abnormal_amino_acid1.98122763
19MP0000579_abnormal_nail_morphology1.85380725
20MP0005409_darkened_coat_color1.81671708
21MP0003191_abnormal_cellular_cholesterol1.81613495
22MP0005501_abnormal_skin_physiology1.78442762
23MP0010678_abnormal_skin_adnexa1.77090245
24MP0003941_abnormal_skin_development1.74349129
25MP0002098_abnormal_vibrissa_morphology1.74247186
26MP0003453_abnormal_keratinocyte_physiol1.74183495
27MP0004264_abnormal_extraembryonic_tissu1.73730655
28MP0000609_abnormal_liver_physiology1.67496904
29MP0002060_abnormal_skin_morphology1.66036095
30MP0009053_abnormal_anal_canal1.58848955
31MP0000383_abnormal_hair_follicle1.55853667
32MP0004381_abnormal_hair_follicle1.54954331
33MP0001216_abnormal_epidermal_layer1.54829199
34MP0005275_abnormal_skin_tensile1.48751398
35MP0002138_abnormal_hepatobiliary_system1.46403657
36MP0002118_abnormal_lipid_homeostasis1.44495035
37MP0000465_gastrointestinal_hemorrhage1.43949436
38MP0001851_eye_inflammation1.39556149
39MP0005451_abnormal_body_composition1.39265627
40MP0005319_abnormal_enzyme/_coenzyme1.37544119
41MP0009780_abnormal_chondrocyte_physiolo1.36937354
42MP0003724_increased_susceptibility_to1.35179319
43MP0003950_abnormal_plasma_membrane1.34938753
44MP0000467_abnormal_esophagus_morphology1.33527294
45MP0010352_gastrointestinal_tract_polyps1.33079187
46MP0003186_abnormal_redox_activity1.32735581
47MP0005164_abnormal_response_to1.31810422
48MP0006054_spinal_hemorrhage1.27631045
49MP0000377_abnormal_hair_follicle1.25324488
50MP0000566_synostosis1.25273658
51MP0010368_abnormal_lymphatic_system1.22094441
52MP0003011_delayed_dark_adaptation1.19824737
53MP0002877_abnormal_melanocyte_morpholog1.18955581
54MP0000678_abnormal_parathyroid_gland1.17199962
55MP0000537_abnormal_urethra_morphology1.16698680
56MP0010386_abnormal_urinary_bladder1.12569952
57MP0009643_abnormal_urine_homeostasis1.11313224
58MP0003868_abnormal_feces_composition1.10090601
59MP0000647_abnormal_sebaceous_gland1.09719796
60MP0001958_emphysema1.08597293
61MP0005165_increased_susceptibility_to1.07602316
62MP0002166_altered_tumor_susceptibility1.07132927
63MP0008004_abnormal_stomach_pH1.06891565
64MP0003300_gastrointestinal_ulcer1.05557887
65MP0001849_ear_inflammation1.04367989
66MP0005023_abnormal_wound_healing1.04251757
67MP0001764_abnormal_homeostasis1.04031710
68MP0000762_abnormal_tongue_morphology1.03941904
69MP0010771_integument_phenotype1.03836893
70MP0003566_abnormal_cell_adhesion1.03675097
71MP0005248_abnormal_Harderian_gland1.03555574
72MP0000427_abnormal_hair_cycle1.02467734
73MP0001346_abnormal_lacrimal_gland1.01091323
74MP0000858_altered_metastatic_potential0.93758409
75MP0003828_pulmonary_edema0.92678925
76MP0008438_abnormal_cutaneous_collagen0.91432630
77MP0005584_abnormal_enzyme/coenzyme_acti0.88693582
78MP0005647_abnormal_sex_gland0.87255903
79MP0008260_abnormal_autophagy0.87225401
80MP0003091_abnormal_cell_migration0.85274208
81MP0004883_abnormal_blood_vessel0.83566668
82MP0004947_skin_inflammation0.83270999
83MP0000598_abnormal_liver_morphology0.82637875
84MP0003718_maternal_effect0.81583713
85MP0002006_tumorigenesis0.81413080
86MP0005388_respiratory_system_phenotype0.79820426
87MP0002133_abnormal_respiratory_system0.79820426
88MP0004782_abnormal_surfactant_physiolog0.79769253
89MP0004272_abnormal_basement_membrane0.79730454
90MP0009931_abnormal_skin_appearance0.78714611
91MP0003436_decreased_susceptibility_to0.77828587
92MP0009697_abnormal_copulation0.77381337
93MP0003045_fibrosis0.76958301
94MP0005408_hypopigmentation0.76863805
95MP0010155_abnormal_intestine_physiology0.76524822
96MP0005166_decreased_susceptibility_to0.73424405
97MP0001879_abnormal_lymphatic_vessel0.73385466
98MP0002168_other_aberrant_phenotype0.73169236
99MP0005076_abnormal_cell_differentiation0.72678086
100MP0009764_decreased_sensitivity_to0.72309066
101MP0000627_abnormal_mammary_gland0.72179440
102MP0010030_abnormal_orbit_morphology0.68801250
103MP0009763_increased_sensitivity_to0.68300656
104MP0001243_abnormal_dermal_layer0.67666411
105MP0003075_altered_response_to0.67514595
106MP0001765_abnormal_ion_homeostasis0.67455478
107MP0002282_abnormal_trachea_morphology0.65849084
108MP0003315_abnormal_perineum_morphology0.64257879
109MP0001533_abnormal_skeleton_physiology0.62846713
110MP0009379_abnormal_foot_pigmentation0.62444744
111MP0005636_abnormal_mineral_homeostasis0.62394743
112MP0005197_abnormal_uvea_morphology0.62245178
113MP0001191_abnormal_skin_condition0.62174709
114MP0002896_abnormal_bone_mineralization0.60753417
115MP0000249_abnormal_blood_vessel0.60662036
116MP0000367_abnormal_coat/_hair0.59381459
117MP0009785_altered_susceptibility_to0.58443823
118MP0004185_abnormal_adipocyte_glucose0.58208645
119MP0001881_abnormal_mammary_gland0.57932245
120MP0004043_abnormal_pH_regulation0.57558399
121MP0004885_abnormal_endolymph0.57278312
122MP0009765_abnormal_xenobiotic_induced0.57267264
123MP0002136_abnormal_kidney_physiology0.56782150
124MP0001756_abnormal_urination0.56153054
125MP0005377_hearing/vestibular/ear_phenot0.55253463
126MP0003878_abnormal_ear_physiology0.55253463
127MP0002234_abnormal_pharynx_morphology0.54866167
128MP0003448_altered_tumor_morphology0.53006297
129MP0005395_other_phenotype0.52375167
130MP0004484_altered_response_of0.51667149
131MP0009384_cardiac_valve_regurgitation0.51371214
132MP0005376_homeostasis/metabolism_phenot0.50251148
133MP0005220_abnormal_exocrine_pancreas0.49780335
134MP0000538_abnormal_urinary_bladder0.49521819
135MP0000613_abnormal_salivary_gland0.49213415
136MP0005670_abnormal_white_adipose0.49134696
137MP0009642_abnormal_blood_homeostasis0.48651385
138MP0003656_abnormal_erythrocyte_physiolo0.47954112
139MP0005666_abnormal_adipose_tissue0.47636833
140MP0003638_abnormal_response/metabolism_0.47067730
141MP0002249_abnormal_larynx_morphology0.46984453
142MP0000604_amyloidosis0.46037758
143MP0008469_abnormal_protein_level0.44312143
144MP0005266_abnormal_metabolism0.43879436
145MP0000477_abnormal_intestine_morphology0.42339293
146MP0003936_abnormal_reproductive_system0.41553685
147MP0000462_abnormal_digestive_system0.41219864

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.59065892
2Abnormality of monocarboxylic acid metabolism (HP:0010996)6.25537435
3Deep venous thrombosis (HP:0002625)5.93653171
4Thick nail (HP:0001805)5.78810016
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.61364623
6Hypobetalipoproteinemia (HP:0003563)5.54897704
7Xanthomatosis (HP:0000991)5.30969884
8Prolonged partial thromboplastin time (HP:0003645)4.92187965
9Onycholysis (HP:0001806)4.44548472
10Right ventricular cardiomyopathy (HP:0011663)4.31590206
11Hyperlipoproteinemia (HP:0010980)4.29278603
12Hypolipoproteinemia (HP:0010981)4.26157050
13Epidermoid cyst (HP:0200040)4.13378037
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12487339
15Oral leukoplakia (HP:0002745)4.06676865
16Hyperammonemia (HP:0001987)3.97574190
17Complement deficiency (HP:0004431)3.94311716
18Hyperglycinemia (HP:0002154)3.88299682
19Hyperglycinuria (HP:0003108)3.85668871
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.77812178
21Abnormality of the axillary hair (HP:0100134)3.74062177
22Abnormality of secondary sexual hair (HP:0009888)3.74062177
23Hypoalphalipoproteinemia (HP:0003233)3.73637657
24Interstitial pulmonary disease (HP:0006530)3.73125025
25Fat malabsorption (HP:0002630)3.65158769
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.62735907
27Abnormality of glycine metabolism (HP:0010895)3.59929934
28Abnormality of serine family amino acid metabolism (HP:0010894)3.59929934
29Abnormality of pyrimidine metabolism (HP:0004353)3.53081222
30Erythema (HP:0010783)3.48694757
31Plantar hyperkeratosis (HP:0007556)3.46340377
32Abnormality of methionine metabolism (HP:0010901)3.42745828
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.42022058
34Abnormality of the common coagulation pathway (HP:0010990)3.38645016
35Corneal erosion (HP:0200020)3.34999629
36Joint hemorrhage (HP:0005261)3.26750579
37Fragile nails (HP:0001808)3.25103458
38Hypoglycemic coma (HP:0001325)3.24753423
39Milia (HP:0001056)3.21427212
40Ridged nail (HP:0001807)3.17005409
41Abnormality of complement system (HP:0005339)3.07575107
42Increased IgE level (HP:0003212)3.02431031
43Ketosis (HP:0001946)3.01146799
44Conjugated hyperbilirubinemia (HP:0002908)2.95728044
45Hypercholesterolemia (HP:0003124)2.94764658
46Hyperactive renin-angiotensin system (HP:0000841)2.87178642
47Abnormality of the intrinsic pathway (HP:0010989)2.83479064
48Vascular calcification (HP:0004934)2.82547082
49Abnormality of fatty-acid metabolism (HP:0004359)2.78530207
50Hepatocellular carcinoma (HP:0001402)2.76185214
51Steatorrhea (HP:0002570)2.75891586
52Abnormality of nucleobase metabolism (HP:0010932)2.75326459
53Amelogenesis imperfecta (HP:0000705)2.70129954
54Hypoplasia of dental enamel (HP:0006297)2.70058608
55Absent eyelashes (HP:0000561)2.69244543
56Abnormality of the salivary glands (HP:0010286)2.67450691
57Alopecia of scalp (HP:0002293)2.66193881
58Malnutrition (HP:0004395)2.64304751
59Ectropion (HP:0000656)2.64076262
60Spastic diplegia (HP:0001264)2.59322576
61Palmoplantar keratoderma (HP:0000982)2.59245706
62Flat acetabular roof (HP:0003180)2.58687718
63Chronic bronchitis (HP:0004469)2.57951413
64Woolly hair (HP:0002224)2.56041299
65Abnormality of serum amino acid levels (HP:0003112)2.55527202
66Palmoplantar hyperkeratosis (HP:0000972)2.54804808
67Delayed CNS myelination (HP:0002188)2.52070904
68Abnormal hemoglobin (HP:0011902)2.49449144
69Myocardial infarction (HP:0001658)2.48205557
70Esophageal varix (HP:0002040)2.47671484
71Hydroxyprolinuria (HP:0003080)2.46111478
72Abnormality of proline metabolism (HP:0010907)2.46111478
73Nail dystrophy (HP:0008404)2.45396435
74Cardiovascular calcification (HP:0011915)2.44770891
75Hyperbilirubinemia (HP:0002904)2.43379096
76Hypochromic microcytic anemia (HP:0004840)2.42352362
77Abnormality of nail color (HP:0100643)2.41982395
78Palmar hyperkeratosis (HP:0010765)2.41603594
79Popliteal pterygium (HP:0009756)2.40860751
80Osteolytic defects of the phalanges of the hand (HP:0009771)2.38370500
81Osteolytic defects of the hand bones (HP:0009699)2.38370500
82Gout (HP:0001997)2.37296793
83Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.36609851
84Abnormality of purine metabolism (HP:0004352)2.36449078
85Blepharitis (HP:0000498)2.35409804
86Pili torti (HP:0003777)2.34652748
87Pustule (HP:0200039)2.34375953
88Hypoplastic labia majora (HP:0000059)2.31602124
89Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.30789824
90Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28642727
91Dicarboxylic aciduria (HP:0003215)2.28642727
92Sparse scalp hair (HP:0002209)2.28600925
93Lethargy (HP:0001254)2.23552528
94Natal tooth (HP:0000695)2.23168144
95Xerostomia (HP:0000217)2.22733376
96Lip pit (HP:0100267)2.22622545
97Dry hair (HP:0011359)2.20676554
98Atrophic scars (HP:0001075)2.19258298
99Parakeratosis (HP:0001036)2.17282635
100Abnormality of permanent molar morphology (HP:0011071)2.16946572
101Abnormality of the dental root (HP:0006486)2.16946572
102Taurodontia (HP:0000679)2.16946572
103Metabolic acidosis (HP:0001942)2.15336232
104Hypotrichosis (HP:0001006)2.14978253
105Hemorrhage of the eye (HP:0011885)2.14757476
106Advanced eruption of teeth (HP:0006288)2.14467292
107Spontaneous abortion (HP:0005268)2.13925646
108Abnormal hair laboratory examination (HP:0003328)2.13789289
109Oligodontia (HP:0000677)2.13539782
110Abnormal cartilage morphology (HP:0002763)2.11823201
111Rickets (HP:0002748)2.10536893
112Pterygium (HP:0001059)2.09967689
113Abnormal blistering of the skin (HP:0008066)2.09090475
114Selective tooth agenesis (HP:0001592)2.08308340
115Arterial tortuosity (HP:0005116)2.08228954
116Ventricular tachycardia (HP:0004756)2.08186694
117Dehydration (HP:0001944)2.06735380
118Autoamputation (HP:0001218)2.06239760
119Hypohidrosis (HP:0000966)2.05444957
120Congenital ichthyosiform erythroderma (HP:0007431)2.05201744
121Abnormality of the dental pulp (HP:0006479)2.04393264
122Abnormality of the labia majora (HP:0012881)2.03352443
123Abnormality of molar (HP:0011077)1.99837768
124Abnormality of molar morphology (HP:0011070)1.99837768
125Neonatal onset (HP:0003623)1.98865805
126Ketoacidosis (HP:0001993)1.98796277
127Gangrene (HP:0100758)1.98321190
128Fragile skin (HP:0001030)1.95937440
129Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.95674405
130Abnormality of placental membranes (HP:0011409)1.93008942
131Amniotic constriction ring (HP:0009775)1.93008942
132Erythroderma (HP:0001019)1.92359534
133Ankyloglossia (HP:0010296)1.90886425
134Absent hair (HP:0002298)1.90125267
135Irritability (HP:0000737)1.86285706
136Systemic lupus erythematosus (HP:0002725)1.81857123
137Anonychia (HP:0001798)1.81728044
138Palpitations (HP:0001962)1.81197729
139Pruritus (HP:0000989)1.81136358
140Hyperkalemia (HP:0002153)1.81048573
141Short nail (HP:0001799)1.80006167
142Sparse eyelashes (HP:0000653)1.78484276
143Follicular hyperkeratosis (HP:0007502)1.78061035
144Abnormality of the gastric mucosa (HP:0004295)1.77828936
145Hypodontia (HP:0000668)1.77430263
146Skin nodule (HP:0200036)1.77275529
147Hoarse voice (HP:0001609)1.77258866
148Abnormal enzyme/coenzyme activity (HP:0012379)1.76922355
149Generalized aminoaciduria (HP:0002909)1.75780149
150Pancreatitis (HP:0001733)1.75692224
151Carious teeth (HP:0000670)1.75344591
152Acanthocytosis (HP:0001927)1.74573564
153Hyperhidrosis (HP:0000975)1.73740978
154Vascular tortuosity (HP:0004948)1.72651498
155Multifactorial inheritance (HP:0001426)1.72084317
156Curly hair (HP:0002212)1.70465583
157Hyperglycemia (HP:0003074)1.70116498
158Abnormality of the distal phalanges of the toes (HP:0010182)1.69587545
159Renal cortical cysts (HP:0000803)1.66832775
160Abnormality of vitamin metabolism (HP:0100508)1.66661711
161Ileus (HP:0002595)1.66287188
162Glomerulosclerosis (HP:0000096)1.66080406
163Hypoglycemic seizures (HP:0002173)1.64479333
164Skin ulcer (HP:0200042)1.64155506
165Focal segmental glomerulosclerosis (HP:0000097)1.63381488
166Hyperuricemia (HP:0002149)1.62808799
167Increased purine levels (HP:0004368)1.62808799
168Glomerulonephritis (HP:0000099)1.61899369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.92610527
2BCKDK3.65955637
3LATS13.11870249
4FGFR43.08325262
5MST1R2.99041350
6MAP3K32.90547771
7ERN12.74350789
8MST42.52151499
9SIK12.51573774
10FRK2.44115713
11RPS6KB22.40252755
12STK242.16583338
13MAPKAPK32.07789213
14STK38L2.03217122
15PKN21.93447583
16MAP3K121.89120064
17FER1.85377067
18ERBB41.84245146
19PTK61.77347451
20MET1.55612404
21TRIB31.51844987
22PIK3CA1.51044454
23MAP3K21.46216781
24CDK61.45310514
25EIF2AK31.32289497
26DDR21.27011573
27EPHB21.25570405
28PTK21.23367084
29JAK11.19557812
30MAP3K91.18268020
31STK31.15994398
32MAP3K61.14905317
33TTK1.11478886
34PBK1.08725272
35FLT31.07923286
36PDGFRA1.07486694
37ERBB21.06061120
38NEK61.04611238
39TYK21.04030148
40NTRK11.03863317
41MAP2K21.03054285
42DYRK1B1.00033986
43MAP2K60.99451533
44MYLK0.99182554
45MAPK110.98635498
46TRPM70.97542074
47LRRK20.96329948
48TIE10.93881581
49STK100.93655169
50EPHB10.93450741
51PDGFRB0.90218273
52CDK120.88527913
53EPHA30.87655046
54FGFR20.86774338
55NEK90.86027148
56STK380.85067683
57PDK20.84331737
58MAP3K110.82040500
59BRSK20.81890855
60LATS20.81244375
61PIK3CG0.80182664
62MAP3K100.78358308
63AKT30.78011853
64PDK40.76839625
65PDK30.76839625
66EEF2K0.76150882
67PAK40.74287126
68TESK10.74140390
69ZAP700.74049723
70PRKCI0.74037236
71RIPK10.72641936
72NEK10.71804215
73RET0.71581498
74MAP3K140.70813029
75TAOK20.64282407
76YES10.63987927
77MAP3K130.63885146
78MAPK150.63335465
79CDK40.62290989
80BMX0.61985762
81GRK10.61206502
82MAP3K80.61194583
83FGFR10.60907844
84SCYL20.60881442
85ARAF0.60661927
86MAP2K10.59698589
87GRK60.59055004
88WEE10.59022982
89MAP3K70.58918367
90IGF1R0.58334343
91STK390.57734784
92PIM20.56646847
93MAP3K10.56162781
94ABL20.54796695
95GSK3A0.54006965
96TAOK30.52330446
97MAPKAPK20.52161325
98INSRR0.51560729
99BMPR20.50420823
100IRAK30.49715182
101MAP2K30.49134242
102MTOR0.48001775
103TGFBR10.46529655
104NUAK10.46023578
105FGFR30.45591101
106TBK10.44501960
107RPS6KA40.44063361
108SIK30.43017348
109JAK20.42051748
110CHUK0.41818037
111AURKB0.41717864
112BCR0.41641946
113MATK0.41614285
114CDK70.40919966
115TGFBR20.40694531
116IRAK10.40548423
117CDC42BPA0.40225958
118EIF2AK10.39936764
119LMTK20.38466532
120CSF1R0.37315328
121ABL10.36442577
122CSNK1E0.36381448
123PRKCE0.36220444
124TSSK60.36134591
125NME20.35070967
126ZAK0.33825214
127PDPK10.33606104
128RPS6KB10.33357098
129PRKAA20.32786344
130RPS6KA10.31769058
131DMPK0.30653722
132CSK0.29874518
133CDK80.28907371
134IKBKB0.28857280
135SGK30.28284992
136SRC0.28142415
137NME10.27816070
138EGFR0.27788217
139PRKCD0.27074526
140MAP3K50.24995287
141MAPK40.24943092
142NLK0.24100122
143ERBB30.23926658
144MELK0.22628694
145CSNK1D0.22550992

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.91709691
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44541318
3Nitrogen metabolism_Homo sapiens_hsa009102.97649946
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95437369
5Arginine biosynthesis_Homo sapiens_hsa002202.73884687
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.54054998
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.48437689
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.47782257
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.45410063
10Tryptophan metabolism_Homo sapiens_hsa003802.44167901
11Fatty acid degradation_Homo sapiens_hsa000712.42702778
12Complement and coagulation cascades_Homo sapiens_hsa046102.36847713
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34452062
14Chemical carcinogenesis_Homo sapiens_hsa052042.34087122
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18130516
16Sphingolipid metabolism_Homo sapiens_hsa006002.17237486
17Histidine metabolism_Homo sapiens_hsa003402.14821507
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.08559242
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.04401314
20Cyanoamino acid metabolism_Homo sapiens_hsa004602.02331704
21Retinol metabolism_Homo sapiens_hsa008301.97989595
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.95649588
23Phenylalanine metabolism_Homo sapiens_hsa003601.85766064
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.84757801
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.83006357
26Caffeine metabolism_Homo sapiens_hsa002321.82244101
27beta-Alanine metabolism_Homo sapiens_hsa004101.80542239
28Peroxisome_Homo sapiens_hsa041461.80452049
29Propanoate metabolism_Homo sapiens_hsa006401.70305414
30PPAR signaling pathway_Homo sapiens_hsa033201.70293857
31Butanoate metabolism_Homo sapiens_hsa006501.69662961
32Fatty acid metabolism_Homo sapiens_hsa012121.62949379
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62647966
34Selenocompound metabolism_Homo sapiens_hsa004501.59786994
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52282601
36Tyrosine metabolism_Homo sapiens_hsa003501.51559054
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49837291
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.48508438
39Folate biosynthesis_Homo sapiens_hsa007901.45418484
40Staphylococcus aureus infection_Homo sapiens_hsa051501.41224434
41Fat digestion and absorption_Homo sapiens_hsa049751.39357572
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38656348
43Sulfur metabolism_Homo sapiens_hsa009201.36330357
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.31833128
45Bile secretion_Homo sapiens_hsa049761.26766223
46Toxoplasmosis_Homo sapiens_hsa051451.25570259
47Biosynthesis of amino acids_Homo sapiens_hsa012301.24755208
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.24532820
49Focal adhesion_Homo sapiens_hsa045101.23145464
50Glutathione metabolism_Homo sapiens_hsa004801.20872943
51Pyruvate metabolism_Homo sapiens_hsa006201.20598018
52Starch and sucrose metabolism_Homo sapiens_hsa005001.19967609
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.19263517
54Other glycan degradation_Homo sapiens_hsa005111.18312154
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17599150
56Carbon metabolism_Homo sapiens_hsa012001.15373571
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14885655
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14424096
59Autoimmune thyroid disease_Homo sapiens_hsa053201.14409249
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12787704
61Fatty acid elongation_Homo sapiens_hsa000621.12387973
62Circadian rhythm_Homo sapiens_hsa047101.12200362
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08574832
64One carbon pool by folate_Homo sapiens_hsa006701.08038996
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06188106
66Lysosome_Homo sapiens_hsa041421.03914823
67Graft-versus-host disease_Homo sapiens_hsa053321.02098434
68Vitamin digestion and absorption_Homo sapiens_hsa049771.01603007
69Pertussis_Homo sapiens_hsa051331.00374814
70ABC transporters_Homo sapiens_hsa020100.98042522
71Allograft rejection_Homo sapiens_hsa053300.97362625
72Arginine and proline metabolism_Homo sapiens_hsa003300.93695059
73Asthma_Homo sapiens_hsa053100.92969001
74Antigen processing and presentation_Homo sapiens_hsa046120.91895028
75Ether lipid metabolism_Homo sapiens_hsa005650.90589175
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88499108
77Steroid biosynthesis_Homo sapiens_hsa001000.87378502
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.85881053
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84268401
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84113339
81Influenza A_Homo sapiens_hsa051640.83319954
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83277395
83Lysine degradation_Homo sapiens_hsa003100.80328647
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80313138
85Malaria_Homo sapiens_hsa051440.78993936
86Vitamin B6 metabolism_Homo sapiens_hsa007500.77686825
87Sulfur relay system_Homo sapiens_hsa041220.76554682
88Pentose phosphate pathway_Homo sapiens_hsa000300.72704057
89Pancreatic cancer_Homo sapiens_hsa052120.70572249
90Leishmaniasis_Homo sapiens_hsa051400.67779094
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66667224
92Viral myocarditis_Homo sapiens_hsa054160.66024430
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65004233
94Linoleic acid metabolism_Homo sapiens_hsa005910.62988470
95Ovarian steroidogenesis_Homo sapiens_hsa049130.62982537
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62781990
97Glycerolipid metabolism_Homo sapiens_hsa005610.62299394
98TNF signaling pathway_Homo sapiens_hsa046680.61396942
99Fatty acid biosynthesis_Homo sapiens_hsa000610.61250300
100Renal cell carcinoma_Homo sapiens_hsa052110.61176671
101Hematopoietic cell lineage_Homo sapiens_hsa046400.60361370
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55980949
103African trypanosomiasis_Homo sapiens_hsa051430.55706613
104VEGF signaling pathway_Homo sapiens_hsa043700.54740675
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54143348
106Type I diabetes mellitus_Homo sapiens_hsa049400.52742329
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51413711
108N-Glycan biosynthesis_Homo sapiens_hsa005100.51244594
109Phagosome_Homo sapiens_hsa041450.51226379
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.47215404
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45345884
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44984990
113Metabolic pathways_Homo sapiens_hsa011000.44968651
114Galactose metabolism_Homo sapiens_hsa000520.44361792
115Tuberculosis_Homo sapiens_hsa051520.44174893
116Endocytosis_Homo sapiens_hsa041440.42750268
117Fructose and mannose metabolism_Homo sapiens_hsa000510.41498827
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41485769
119Pancreatic secretion_Homo sapiens_hsa049720.39834521
120Choline metabolism in cancer_Homo sapiens_hsa052310.39581112
121Notch signaling pathway_Homo sapiens_hsa043300.39320186
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38888191
123Salmonella infection_Homo sapiens_hsa051320.38270118
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36860832
125Arachidonic acid metabolism_Homo sapiens_hsa005900.33739475
126Basal cell carcinoma_Homo sapiens_hsa052170.22508269
127ECM-receptor interaction_Homo sapiens_hsa045120.22386558
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22385888
129Bladder cancer_Homo sapiens_hsa052190.21760979
130Insulin resistance_Homo sapiens_hsa049310.19743719
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.16893880
132Hippo signaling pathway_Homo sapiens_hsa043900.14037754
133Adherens junction_Homo sapiens_hsa045200.13921122
134Ribosome_Homo sapiens_hsa030100.12893352
135Small cell lung cancer_Homo sapiens_hsa052220.12664620
136Mineral absorption_Homo sapiens_hsa049780.11493900
137Tight junction_Homo sapiens_hsa045300.10000501
138Amoebiasis_Homo sapiens_hsa051460.05727073
139Prion diseases_Homo sapiens_hsa050200.05386634
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.05232545
141Hepatitis C_Homo sapiens_hsa051600.05205466
142Thyroid cancer_Homo sapiens_hsa052160.04853075
143Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.03099667
144Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0843575
145p53 signaling pathway_Homo sapiens_hsa04115-0.0673913
146Proteoglycans in cancer_Homo sapiens_hsa05205-0.0649719
147Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0415747
148AMPK signaling pathway_Homo sapiens_hsa04152-0.0288561
149TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0252104
150Renin-angiotensin system_Homo sapiens_hsa04614-0.0179748
151Protein digestion and absorption_Homo sapiens_hsa04974-0.0056386

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