MR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.45086143
2negative regulation of cell killing (GO:0031342)4.27201774
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.27201774
4regulation of B cell receptor signaling pathway (GO:0050855)4.20456772
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.04470616
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.04470616
7positive regulation of gamma-delta T cell activation (GO:0046645)3.81292344
8negative regulation of interleukin-12 production (GO:0032695)3.80765494
9immunoglobulin mediated immune response (GO:0016064)3.75044210
10definitive hemopoiesis (GO:0060216)3.70650657
11cellular extravasation (GO:0045123)3.66839254
12antigen processing and presentation of endogenous antigen (GO:0019883)3.49226948
13positive regulation of natural killer cell differentiation (GO:0032825)3.36511674
14daunorubicin metabolic process (GO:0044597)3.35543851
15polyketide metabolic process (GO:0030638)3.35543851
16doxorubicin metabolic process (GO:0044598)3.35543851
17antigen processing and presentation via MHC class Ib (GO:0002475)3.34396930
18negative regulation of T cell mediated immunity (GO:0002710)3.33262863
19regulation of antigen processing and presentation (GO:0002577)3.32077435
20response to peptidoglycan (GO:0032494)3.27546409
21negative regulation of lymphocyte mediated immunity (GO:0002707)3.20690676
22response to interferon-alpha (GO:0035455)3.18058955
23negative thymic T cell selection (GO:0045060)3.14447825
24negative T cell selection (GO:0043383)3.11473669
25detection of bacterium (GO:0016045)3.08207349
26defense response to protozoan (GO:0042832)3.07789271
27T cell migration (GO:0072678)3.04732364
28regulation of gamma-delta T cell differentiation (GO:0045586)3.04550366
29B cell receptor signaling pathway (GO:0050853)3.04150078
30positive regulation of mast cell activation (GO:0033005)3.03524472
31regulation of gamma-delta T cell activation (GO:0046643)3.00600147
32regulation of interferon-alpha production (GO:0032647)2.99845532
33positive regulation of interferon-alpha production (GO:0032727)2.98864939
34cellular response to interleukin-15 (GO:0071350)2.97983672
35response to protozoan (GO:0001562)2.96203660
36interferon-gamma production (GO:0032609)2.96102757
37positive regulation of defense response to virus by host (GO:0002230)2.96060904
38negative regulation of interleukin-6 production (GO:0032715)2.95700327
39regulation of mast cell activation (GO:0033003)2.92620364
40myeloid cell activation involved in immune response (GO:0002275)2.91237445
41activated T cell proliferation (GO:0050798)2.90290457
42response to interleukin-15 (GO:0070672)2.89537650
43lymph vessel development (GO:0001945)2.88945889
44B cell mediated immunity (GO:0019724)2.85816164
45* regulation of T cell mediated cytotoxicity (GO:0001914)2.85297798
46tolerance induction (GO:0002507)2.84442347
47macrophage activation (GO:0042116)2.84096270
48regulation of regulatory T cell differentiation (GO:0045589)2.83876788
49neutrophil activation (GO:0042119)2.83299968
50valine metabolic process (GO:0006573)2.81254738
51regulation of alpha-beta T cell proliferation (GO:0046640)2.80838729
52* positive regulation of T cell mediated cytotoxicity (GO:0001916)2.78695745
53negative regulation of leukocyte mediated immunity (GO:0002704)2.78097552
54regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.77814540
55regulation of natural killer cell mediated immunity (GO:0002715)2.77814540
56leukocyte aggregation (GO:0070486)2.74602389
57regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.73451464
58regulation of tolerance induction (GO:0002643)2.73287720
59positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.72519376
60granulocyte activation (GO:0036230)2.70463216
61regulation of T cell tolerance induction (GO:0002664)2.69482236
62positive thymic T cell selection (GO:0045059)2.67691052
63positive regulation of T-helper 1 type immune response (GO:0002827)2.67288314
64positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.66788455
65regulation of dendritic cell antigen processing and presentation (GO:0002604)2.65705881
66regulation of natural killer cell differentiation (GO:0032823)2.65094781
67cellular response to exogenous dsRNA (GO:0071360)2.64687256
68negative regulation of erythrocyte differentiation (GO:0045647)2.63941838
69negative regulation of innate immune response (GO:0045824)2.61115862
70xenobiotic catabolic process (GO:0042178)2.59387833
71regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.57810742
72response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.57716693
73response to host (GO:0075136)2.57716693
74response to host defenses (GO:0052200)2.57716693
75regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.56935369
76phagocytosis, engulfment (GO:0006911)2.56722018
77regulation of hypersensitivity (GO:0002883)2.55722755
78negative regulation of lipid storage (GO:0010888)2.54341910
79regulation of mast cell degranulation (GO:0043304)2.52905695
80negative regulation of bone resorption (GO:0045779)2.52665567
81positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.51859841
82detection of molecule of bacterial origin (GO:0032490)2.51177857
83positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.51128879
84regulation of interleukin-12 production (GO:0032655)2.49837213
85positive regulation by organism of defense response of other organism involved in symbiotic interact2.49589691
86modulation by symbiont of host immune response (GO:0052553)2.49589691
87positive regulation by symbiont of host defense response (GO:0052509)2.49589691
88modulation by symbiont of host defense response (GO:0052031)2.49589691
89modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.49589691
90modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.49589691
91negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.49356000
92T cell selection (GO:0045058)2.49208638
93regulation of memory T cell differentiation (GO:0043380)2.49169370
94positive regulation of mast cell degranulation (GO:0043306)2.48985143
95positive regulation of mast cell activation involved in immune response (GO:0033008)2.48985143
96negative regulation of stress fiber assembly (GO:0051497)2.41858581
97positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.40712505
98response to type I interferon (GO:0034340)2.39586097
99positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.38777395
100T-helper 1 type immune response (GO:0042088)2.38463489
101negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.37704544
102macrophage activation involved in immune response (GO:0002281)2.35189399
103keratan sulfate catabolic process (GO:0042340)2.35043152
104positive regulation of cellular amide metabolic process (GO:0034250)2.34414351
105JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.33222967
106regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.33100551
107cellular response to type I interferon (GO:0071357)2.31673114
108type I interferon signaling pathway (GO:0060337)2.31673114
109endosome to melanosome transport (GO:0035646)2.30194213
110endosome to pigment granule transport (GO:0043485)2.30194213
111regulation of interferon-beta biosynthetic process (GO:0045357)2.29512975
112positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.27814125
113response to laminar fluid shear stress (GO:0034616)2.27450205
114positive regulation of B cell differentiation (GO:0045579)2.27444891
115toxin transport (GO:1901998)2.26803127
116gland morphogenesis (GO:0022612)2.26762501
117detection of other organism (GO:0098543)2.26472580
118cellular response to zinc ion (GO:0071294)2.24858699
119regulation of skeletal muscle contraction (GO:0014819)2.23508534
120positive regulation of macrophage cytokine production (GO:0060907)2.23052968
121regulation of interleukin-12 biosynthetic process (GO:0045075)2.22088935
122detection of external biotic stimulus (GO:0098581)2.21463005
123positive regulation of cholesterol efflux (GO:0010875)2.20944117
124blood vessel maturation (GO:0001955)2.20279737
125response to interferon-beta (GO:0035456)2.18187826
126regulation of B cell differentiation (GO:0045577)2.17800580
127negative regulation of granulocyte differentiation (GO:0030853)2.17243635
128positive regulation of antigen processing and presentation (GO:0002579)2.15692156
129venous blood vessel morphogenesis (GO:0048845)2.14872630
130production of molecular mediator involved in inflammatory response (GO:0002532)2.14594027
131regulation of macrophage cytokine production (GO:0010935)2.14203181
132neutrophil activation involved in immune response (GO:0002283)2.12355631
133positive regulation of macrophage differentiation (GO:0045651)2.12320394
134pinocytosis (GO:0006907)2.10473189
135cell adhesion mediated by integrin (GO:0033627)2.09730960
136vascular endothelial growth factor signaling pathway (GO:0038084)2.07985740
137mesenchymal-epithelial cell signaling (GO:0060638)2.07653846
138cellular response to thyroid hormone stimulus (GO:0097067)2.07394303
139regulation of heterotypic cell-cell adhesion (GO:0034114)2.06929481
140cellular response to interferon-alpha (GO:0035457)2.06663544
141positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.06655121
142response to fluid shear stress (GO:0034405)2.06453754
143negative regulation of protein autophosphorylation (GO:0031953)2.06028025
144regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.04964610
145microglial cell activation (GO:0001774)2.02102553
146positive regulation of sterol transport (GO:0032373)2.01963365
147positive regulation of cholesterol transport (GO:0032376)2.01963365
148growth hormone receptor signaling pathway (GO:0060396)2.01198050
149interferon-gamma-mediated signaling pathway (GO:0060333)2.00392127
150platelet dense granule organization (GO:0060155)1.99241191
151cell differentiation involved in metanephros development (GO:0072202)1.98770536
152positive regulation of chemokine secretion (GO:0090197)1.98670236
153cellular response to growth hormone stimulus (GO:0071378)1.97117982
154apoptotic cell clearance (GO:0043277)1.96911788
155germ cell migration (GO:0008354)1.96195550
156negative regulation of biomineral tissue development (GO:0070168)1.96143224
157negative regulation of nitric oxide biosynthetic process (GO:0045019)1.93954260
158regulation of interleukin-8 secretion (GO:2000482)1.93838420
159detection of biotic stimulus (GO:0009595)1.92788451
160response to host immune response (GO:0052572)1.92684404
161response to immune response of other organism involved in symbiotic interaction (GO:0052564)1.92684404
162regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.91931397
163positive regulation of natural killer cell activation (GO:0032816)1.91685417
164response to nitrosative stress (GO:0051409)1.91640940
165positive regulation of respiratory burst (GO:0060267)1.91548973

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.66869985
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.41770599
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.09033096
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.43412968
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.22166453
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.63476986
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.60966213
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.57190440
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.56285205
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.56061950
11SCL_19346495_ChIP-Seq_HPC-7_Human2.44587774
12RUNX_20019798_ChIP-Seq_JUKART_Human2.35804342
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28283810
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.22364705
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.21709023
16* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20771972
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.18677903
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.17784034
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.17720179
20CLOCK_20551151_ChIP-Seq_293T_Human2.15204617
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.08253155
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.07798394
23* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.05926300
24GATA2_21666600_ChIP-Seq_HMVEC_Human2.00890632
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.96541265
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.90325680
27GATA3_26560356_Chip-Seq_TH2_Human1.87567325
28GATA1_22025678_ChIP-Seq_K562_Human1.82362349
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.82096687
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76434734
31LXR_22158963_ChIP-Seq_LIVER_Mouse1.73617291
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71956346
33CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.71594701
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71188343
35* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.70288112
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.68138174
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.67698599
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.67698599
39SPI1_23127762_ChIP-Seq_K562_Human1.66706246
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.66206411
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.64804211
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61461606
43CJUN_26792858_Chip-Seq_BT549_Human1.61042566
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.55401224
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54333270
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53834990
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53461312
48* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52120472
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.51007597
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49637973
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49017312
52SOX2_20726797_ChIP-Seq_SW620_Human1.46381140
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.45817317
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.41600474
55* MYB_26560356_Chip-Seq_TH2_Human1.37803453
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37557579
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36375535
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36027549
59FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34100437
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31266262
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29909149
62VDR_24787735_ChIP-Seq_THP-1_Human1.29560115
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.28505541
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26638774
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25793976
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25793976
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.24437789
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23157291
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.20786036
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18547627
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.17489831
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13829510
73SMRT_27268052_Chip-Seq_Bcells_Human1.13795568
74ZNF274_21170338_ChIP-Seq_K562_Hela1.13180312
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11295760
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11047489
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09752260
78MAF_26560356_Chip-Seq_TH1_Human1.09731694
79* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09054134
80MYB_26560356_Chip-Seq_TH1_Human1.07937966
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07365591
82TP53_18474530_ChIP-ChIP_U2OS_Human1.07023082
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06920249
84* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06714147
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05955263
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02869104
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02848927
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02505562
89* PU_27001747_Chip-Seq_BMDM_Mouse1.01879680
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01019164
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00886197
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00810248
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00327984
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.98850146
95GATA2_19941826_ChIP-Seq_K562_Human0.98654647
96ER_23166858_ChIP-Seq_MCF-7_Human0.98126598
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97944641
98TBX20_22328084_ChIP-Seq_HEART_Mouse0.97908518
99TBX20_22080862_ChIP-Seq_HEART_Mouse0.97908518
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97842608
101PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97750318
102GATA3_27048872_Chip-Seq_THYMUS_Human0.96761177
103NOTCH1_21737748_ChIP-Seq_TLL_Human0.95762452
104WT1_19549856_ChIP-ChIP_CCG9911_Human0.95692288
105IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95108245
106EP300_21415370_ChIP-Seq_HL-1_Mouse0.94767392
107UTX_26944678_Chip-Seq_JUKART_Human0.94371798
108FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94359896
109* SPI1_23547873_ChIP-Seq_NB4_Human0.94058649
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93944351
111VDR_24763502_ChIP-Seq_THP-1_Human0.93386521
112RUNX1_22412390_ChIP-Seq_EML_Mouse0.92705428
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92271835
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91731207
115GATA3_21878914_ChIP-Seq_MCF-7_Human0.88700528
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88589920
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.88030568
118NFE2_27457419_Chip-Seq_LIVER_Mouse0.87970109
119GATA1_19941826_ChIP-Seq_K562_Human0.87738132
120PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87023752
121JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87020985
122* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85950693
123CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85029840
124CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83678125
125GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.83525729
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83468404
127BRD4_25478319_ChIP-Seq_HGPS_Human0.83324327
128NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83190983
129BCAT_22108803_ChIP-Seq_LS180_Human0.82863467
130TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82794240
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.82031597
132* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.81158582
133FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81050705
134STAT1_20625510_ChIP-Seq_HELA_Human0.81018316
135RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80426994
136MAF_26560356_Chip-Seq_TH2_Human0.80350847
137EZH2_27294783_Chip-Seq_NPCs_Mouse0.79428983
138EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76920913
139RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76918506
140TP53_16413492_ChIP-PET_HCT116_Human0.76271349
141AHR_22903824_ChIP-Seq_MCF-7_Human0.76136710
142GATA3_26560356_Chip-Seq_TH1_Human0.76133356
143* CRX_20693478_ChIP-Seq_RETINA_Mouse0.76072868
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75974597
145FOXA1_21572438_ChIP-Seq_LNCaP_Human0.75941702
146RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75604896
147VDR_22108803_ChIP-Seq_LS180_Human0.74484073
148PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73417559
149GATA2_22383799_ChIP-Seq_G1ME_Mouse0.73214899
150ARNT_22903824_ChIP-Seq_MCF-7_Human0.73095364
151GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71602161
152FOXA1_27270436_Chip-Seq_PROSTATE_Human0.71121700

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.59958681
2MP0003303_peritoneal_inflammation2.65095649
3MP0002166_altered_tumor_susceptibility2.59032104
4MP0001835_abnormal_antigen_presentation2.49930876
5MP0005275_abnormal_skin_tensile2.46208860
6MP0001879_abnormal_lymphatic_vessel2.38442734
7MP0003724_increased_susceptibility_to2.26508049
8MP0003300_gastrointestinal_ulcer2.19170805
9MP0002006_tumorigenesis2.12260987
10MP0009785_altered_susceptibility_to1.99273060
11MP0003279_aneurysm1.98030788
12MP0009384_cardiac_valve_regurgitation1.95324609
13MP0006082_CNS_inflammation1.87632706
14MP0000685_abnormal_immune_system1.82589644
15MP0005310_abnormal_salivary_gland1.82057516
16MP0000569_abnormal_digit_pigmentation1.79952719
17MP0005503_abnormal_tendon_morphology1.76105222
18MP0001958_emphysema1.75130226
19MP0005671_abnormal_response_to1.71191540
20MP0010368_abnormal_lymphatic_system1.70425797
21MP0002419_abnormal_innate_immunity1.69496577
22MP0005058_abnormal_lysosome_morphology1.69077758
23MP0003436_decreased_susceptibility_to1.68911850
24MP0002009_preneoplasia1.65903218
25MP0002148_abnormal_hypersensitivity_rea1.60762382
26MP0009333_abnormal_splenocyte_physiolog1.57168014
27MP0002933_joint_inflammation1.54958030
28MP0005000_abnormal_immune_tolerance1.54327572
29MP0006054_spinal_hemorrhage1.51535808
30MP0005464_abnormal_platelet_physiology1.51201345
31MP0003183_abnormal_peptide_metabolism1.50237605
32MP0005025_abnormal_response_to1.49388931
33MP0001790_abnormal_immune_system1.47840793
34MP0005387_immune_system_phenotype1.47840793
35MP0004947_skin_inflammation1.45041156
36MP0003191_abnormal_cellular_cholesterol1.44583743
37MP0009764_decreased_sensitivity_to1.43318546
38MP0002060_abnormal_skin_morphology1.42526581
39MP0004130_abnormal_muscle_cell1.40349024
40MP0002998_abnormal_bone_remodeling1.40070703
41MP0001533_abnormal_skeleton_physiology1.37953767
42* MP0002452_abnormal_antigen_presenting1.36947176
43MP0010155_abnormal_intestine_physiology1.34595000
44MP0000343_altered_response_to1.31730630
45MP0003690_abnormal_glial_cell1.30698819
46MP0003763_abnormal_thymus_physiology1.29069499
47MP0004272_abnormal_basement_membrane1.28595089
48MP0001853_heart_inflammation1.27412410
49MP0001800_abnormal_humoral_immune1.27386033
50MP0002396_abnormal_hematopoietic_system1.26764740
51MP0004808_abnormal_hematopoietic_stem1.26477340
52MP0002723_abnormal_immune_serum1.24808502
53MP0003866_abnormal_defecation1.24253108
54* MP0002429_abnormal_blood_cell1.24147751
55MP0003566_abnormal_cell_adhesion1.23798042
56MP0009278_abnormal_bone_marrow1.23370558
57MP0003656_abnormal_erythrocyte_physiolo1.20947094
58MP0001545_abnormal_hematopoietic_system1.20868211
59MP0005397_hematopoietic_system_phenotyp1.20868211
60MP0002138_abnormal_hepatobiliary_system1.20673781
61MP0002877_abnormal_melanocyte_morpholog1.18632564
62MP0002420_abnormal_adaptive_immunity1.17710228
63MP0002132_abnormal_respiratory_system1.17643849
64MP0010386_abnormal_urinary_bladder1.17258513
65MP0001819_abnormal_immune_cell1.16228093
66MP0002254_reproductive_system_inflammat1.16191385
67MP0002295_abnormal_pulmonary_circulatio1.15212895
68MP0002405_respiratory_system_inflammati1.12994362
69MP0005670_abnormal_white_adipose1.11994761
70MP0003828_pulmonary_edema1.11154363
71MP0001845_abnormal_inflammatory_respons1.10618160
72MP0005023_abnormal_wound_healing1.10169798
73MP0000767_abnormal_smooth_muscle1.07977202
74MP0005390_skeleton_phenotype1.06730551
75MP0002693_abnormal_pancreas_physiology1.05685876
76MP0003075_altered_response_to1.05676849
77MP0005164_abnormal_response_to1.05562298
78MP0003186_abnormal_redox_activity1.03158830
79MP0000604_amyloidosis1.02899221
80MP0008469_abnormal_protein_level1.02563849
81MP0004782_abnormal_surfactant_physiolog1.00721880
82MP0003705_abnormal_hypodermis_morpholog1.00282954
83MP0002876_abnormal_thyroid_physiology0.99250271
84MP0002277_abnormal_respiratory_mucosa0.98709349
85MP0000465_gastrointestinal_hemorrhage0.98563594
86MP0003172_abnormal_lysosome_physiology0.94802346
87MP0005508_abnormal_skeleton_morphology0.93999260
88MP0009840_abnormal_foam_cell0.92245619
89MP0000372_irregular_coat_pigmentation0.91219093
90MP0003806_abnormal_nucleotide_metabolis0.90715299
91MP0003252_abnormal_bile_duct0.90436195
92MP0000703_abnormal_thymus_morphology0.90172427
93MP0000015_abnormal_ear_pigmentation0.86976836
94MP0008004_abnormal_stomach_pH0.86677937
95MP0003795_abnormal_bone_structure0.86210938
96MP0003011_delayed_dark_adaptation0.85567680
97MP0001986_abnormal_taste_sensitivity0.85472594
98MP0009763_increased_sensitivity_to0.84792497
99MP0001851_eye_inflammation0.84514354
100MP0005166_decreased_susceptibility_to0.84444610
101MP0003448_altered_tumor_morphology0.84396757
102MP0003646_muscle_fatigue0.83708518
103MP0000249_abnormal_blood_vessel0.82890355
104* MP0000716_abnormal_immune_system0.82339969
105MP0003943_abnormal_hepatobiliary_system0.81177291
106MP0003045_fibrosis0.80194903
107MP0008875_abnormal_xenobiotic_pharmacok0.79843318
108MP0000858_altered_metastatic_potential0.79008671
109MP0004381_abnormal_hair_follicle0.78572638
110MP0000733_abnormal_muscle_development0.78356552
111MP0001663_abnormal_digestive_system0.78194828
112MP0001849_ear_inflammation0.77829343
113MP0004883_abnormal_blood_vessel0.76844865
114MP0005075_abnormal_melanosome_morpholog0.75899728
115MP0000371_diluted_coat_color0.75535764
116MP0002398_abnormal_bone_marrow0.75207955
117MP0002168_other_aberrant_phenotype0.74413774
118MP0000383_abnormal_hair_follicle0.74127209
119MP0003195_calcinosis0.73947956
120MP0005085_abnormal_gallbladder_physiolo0.73790300
121MP0000689_abnormal_spleen_morphology0.72984856
122MP0001873_stomach_inflammation0.72228951
123MP0005365_abnormal_bile_salt0.71072011
124MP0000427_abnormal_hair_cycle0.71035123
125MP0002722_abnormal_immune_system0.70740025
126MP0009250_abnormal_appendicular_skeleto0.70173712
127MP0005167_abnormal_blood-brain_barrier0.69819967
128MP0002136_abnormal_kidney_physiology0.67850223
129MP0004043_abnormal_pH_regulation0.64978745
130MP0009643_abnormal_urine_homeostasis0.63381192
131MP0002102_abnormal_ear_morphology0.63202495

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.59269274
2Abnormality of liposaccharide metabolism (HP:0010968)4.59269274
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.59269274
4Stomatitis (HP:0010280)4.23045370
5Abnormal delayed hypersensitivity skin test (HP:0002963)3.91149296
6Recurrent cutaneous fungal infections (HP:0011370)3.56528707
7Chronic mucocutaneous candidiasis (HP:0002728)3.56528707
8Pulmonary infiltrates (HP:0002113)3.11053168
9Aortic aneurysm (HP:0004942)3.09601019
10Vasculitis (HP:0002633)3.09433222
11Mediastinal lymphadenopathy (HP:0100721)3.08400016
12Recurrent abscess formation (HP:0002722)3.01224108
13Vacuolated lymphocytes (HP:0001922)3.01090170
14Protrusio acetabuli (HP:0003179)2.99839247
15Broad metatarsal (HP:0001783)2.99688382
16Eczematoid dermatitis (HP:0000976)2.97658745
17Gastrointestinal infarctions (HP:0005244)2.97341581
18Hemoptysis (HP:0002105)2.94212966
19Myositis (HP:0100614)2.92764203
20Keratoconjunctivitis (HP:0001096)2.85618571
21Hematochezia (HP:0002573)2.85486428
22T lymphocytopenia (HP:0005403)2.85196207
23Encephalitis (HP:0002383)2.84175099
24Abnormality of T cell number (HP:0011839)2.84031791
25Chronic otitis media (HP:0000389)2.81402911
26Aortic dissection (HP:0002647)2.80757183
27Abnormality of T cell physiology (HP:0011840)2.72950929
28Orchitis (HP:0100796)2.71937332
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.69017893
30Dysostosis multiplex (HP:0000943)2.65687944
31Spontaneous hematomas (HP:0007420)2.62049054
32Abnormality of macrophages (HP:0004311)2.60535804
33Hypoplasia of the thymus (HP:0000778)2.60230185
34Increased IgM level (HP:0003496)2.55733097
35Elevated erythrocyte sedimentation rate (HP:0003565)2.54244492
36Recurrent viral infections (HP:0004429)2.50260593
37Recurrent bacterial skin infections (HP:0005406)2.41987115
38Chronic obstructive pulmonary disease (HP:0006510)2.37481151
39Obstructive lung disease (HP:0006536)2.37481151
40Mucopolysacchariduria (HP:0008155)2.36450400
41Urinary glycosaminoglycan excretion (HP:0003541)2.36450400
42Gingivitis (HP:0000230)2.35189440
43Urticaria (HP:0001025)2.33790174
44Vascular tortuosity (HP:0004948)2.32819221
45Hypoproteinemia (HP:0003075)2.26647296
46Thyroiditis (HP:0100646)2.26487288
47Chronic diarrhea (HP:0002028)2.24586149
48Chronic sinusitis (HP:0011109)2.24563588
49Eosinophilia (HP:0001880)2.24219372
50Spondylolisthesis (HP:0003302)2.22137202
51Loss of speech (HP:0002371)2.21374507
52Autoimmune thrombocytopenia (HP:0001973)2.20184480
53Agammaglobulinemia (HP:0004432)2.19065959
54IgG deficiency (HP:0004315)2.18733254
55Recurrent fungal infections (HP:0002841)2.18644972
56Abnormality of B cell number (HP:0010975)2.17383151
57B lymphocytopenia (HP:0010976)2.17383151
58Cheilitis (HP:0100825)2.17256261
59Hypergammaglobulinemia (HP:0010702)2.16709018
60Arterial tortuosity (HP:0005116)2.16661651
61Gingival bleeding (HP:0000225)2.16533311
62Premature rupture of membranes (HP:0001788)2.15382669
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.15045481
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.15045481
65Abnormality of polysaccharide metabolism (HP:0011012)2.15045481
66Chest pain (HP:0100749)2.14451619
67Anorexia (HP:0002039)2.14183452
68Recurrent gram-negative bacterial infections (HP:0005420)2.12475750
69Prolonged bleeding time (HP:0003010)2.10490125
70Systemic lupus erythematosus (HP:0002725)2.09857701
71Type 1 muscle fiber predominance (HP:0003803)2.09703495
72Vertebral compression fractures (HP:0002953)2.09009766
73Increased IgE level (HP:0003212)2.08982676
74Pulmonary embolism (HP:0002204)2.08165552
75Optic neuritis (HP:0100653)2.08156649
76Retrobulbar optic neuritis (HP:0100654)2.08156649
77Periodontitis (HP:0000704)2.08141284
78Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07649725
79Gangrene (HP:0100758)2.07412093
80Abnormality of the nasal mucosa (HP:0000433)2.07116953
81Arterial thrombosis (HP:0004420)2.06695150
82Osteolytic defects of the hand bones (HP:0009699)2.05506089
83Osteolytic defects of the phalanges of the hand (HP:0009771)2.05506089
84Congenital stationary night blindness (HP:0007642)2.04375559
85Abnormality of the phalanges of the 2nd finger (HP:0009541)2.04036639
86Hypochromic anemia (HP:0001931)2.03826988
87Cerebral aneurysm (HP:0004944)2.02073237
88Decreased circulating renin level (HP:0003351)2.02010408
89Atrophic scars (HP:0001075)2.01623290
90Broad face (HP:0000283)2.01000459
91Global brain atrophy (HP:0002283)2.00804731
92Abnormality of the pleura (HP:0002103)2.00414573
93Abnormality of secondary sexual hair (HP:0009888)1.99199878
94Abnormality of the axillary hair (HP:0100134)1.99199878
95Abnormality of transition element cation homeostasis (HP:0011030)1.98661085
96Abnormality of the prostate (HP:0008775)1.98089883
97Abnormality of iron homeostasis (HP:0011031)1.97160844
98Beaking of vertebral bodies (HP:0004568)1.96970147
99Panhypogammaglobulinemia (HP:0003139)1.96924828
100Abnormality of T cells (HP:0002843)1.96097372
101Increased serum ferritin (HP:0003281)1.93884106
102Recurrent sinusitis (HP:0011108)1.93393449
103Keratitis (HP:0000491)1.93323271
104Inflammation of the large intestine (HP:0002037)1.92667455
105Epistaxis (HP:0000421)1.92448123
106Episodic fever (HP:0001954)1.91809960
107Cervical subluxation (HP:0003308)1.90933645
108Congenital, generalized hypertrichosis (HP:0004540)1.90178975
109Abnormality of the lumbar spine (HP:0100712)1.89729632
110Short hallux (HP:0010109)1.89670436
111Prostate neoplasm (HP:0100787)1.89178066
112Interstitial pulmonary disease (HP:0006530)1.88668078
113Increased CSF protein (HP:0002922)1.86347675
114Myocardial infarction (HP:0001658)1.86321301
115Leukocytosis (HP:0001974)1.86145041
116Asymmetric septal hypertrophy (HP:0001670)1.84720425
117Attenuation of retinal blood vessels (HP:0007843)1.84668729
118Peritonitis (HP:0002586)1.83348153
119Pustule (HP:0200039)1.82819858
120Abolished electroretinogram (ERG) (HP:0000550)1.82505809
121Tarsal synostosis (HP:0008368)1.82062949
122Joint swelling (HP:0001386)1.81448143
123Granulocytopenia (HP:0001913)1.80441674
124Nephritis (HP:0000123)1.80160457
125Recurrent skin infections (HP:0001581)1.78653779
126Polyneuropathy (HP:0001271)1.77714396
127Lip pit (HP:0100267)1.77407768
128Abnormality of eosinophils (HP:0001879)1.76887372
129Stomach cancer (HP:0012126)1.75678202
130Keratoconjunctivitis sicca (HP:0001097)1.75244943
131Increased neuronal autofluorescent lipopigment (HP:0002074)1.72571363
132Biconcave vertebral bodies (HP:0004586)1.71082564
133Cellulitis (HP:0100658)1.70591897
134Tetraparesis (HP:0002273)1.70169668
135Increased cerebral lipofuscin (HP:0011813)1.69256806
136Mesangial abnormality (HP:0001966)1.69215407
137Aplasia/Hypoplasia of the hallux (HP:0008362)1.68109472
138Craniofacial hyperostosis (HP:0004493)1.67861868
139Facial diplegia (HP:0001349)1.66886673
140Abnormality of the nasal septum (HP:0000419)1.65851319
141Hydroxyprolinuria (HP:0003080)1.65638885
142Abnormality of proline metabolism (HP:0010907)1.65638885
143Glomerulonephritis (HP:0000099)1.64358588
144Autoimmune hemolytic anemia (HP:0001890)1.63848521
145Hyperlipoproteinemia (HP:0010980)1.63637236
146Recurrent bronchitis (HP:0002837)1.63591109
147Thrombocytosis (HP:0001894)1.63376966
148Subacute progressive viral hepatitis (HP:0006572)1.63245867
149Follicular hyperkeratosis (HP:0007502)1.62708657
150Meningitis (HP:0001287)1.62290022
151Cardiovascular calcification (HP:0011915)1.61982624
152Purpura (HP:0000979)1.61513836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR23.60870928
2ADRBK22.38151071
3KIT2.30968538
4ERN12.26573463
5SIK12.15953710
6JAK32.14828533
7FRK2.12829773
8ACVR1B2.09425698
9TXK2.08430706
10TRIB31.96231884
11MAP3K141.84619440
12MAPK151.84517891
13CAMK1D1.82117846
14TEC1.77995677
15MYLK1.68273605
16MAP4K11.66298264
17BLK1.63581317
18FLT31.62389404
19TYK21.61792015
20FES1.60234301
21MAP2K31.56140642
22BTK1.55846700
23TTN1.55274193
24TIE11.54406972
25EPHA31.53723492
26LRRK21.52325901
27STK101.51881575
28NUAK11.50321545
29ZAP701.42998209
30FGFR41.42331054
31IKBKE1.42305965
32PKN21.41786585
33TBK11.38059312
34TRPM71.37871155
35FGFR31.36867708
36PIK3CG1.35383827
37INSRR1.34733595
38NME21.32309199
39JAK11.32305326
40PIM21.31834008
41GRK61.30547139
42DAPK21.29553091
43IRAK11.29512250
44TLK11.23017831
45MST41.22774672
46NEK91.20868897
47RIPK11.18598614
48MAP3K31.15991868
49ITK1.14911228
50IRAK41.11190530
51CAMKK21.10966637
52CSF1R1.10666183
53NLK1.06629486
54TGFBR11.05127290
55FGR1.04315469
56IKBKB1.04277222
57CSK1.00125375
58FGFR20.98849438
59GRK10.98105631
60SYK0.96545747
61CAMK1G0.96456570
62PTK2B0.96150316
63EPHB10.95670486
64ZAK0.95401221
65PDGFRB0.95332238
66MAP2K60.94706106
67KDR0.93085302
68MAP3K70.92762974
69DDR20.92552133
70MST1R0.88264542
71CDK60.87258865
72LCK0.86493507
73TNK20.85565723
74RIPK40.83969246
75ADRBK10.83821003
76MAPK70.83291464
77GRK70.83243897
78PTK60.83056637
79PDK10.82576368
80PDGFRA0.82092735
81IRAK30.82056166
82PINK10.82043072
83PIK3CA0.80269953
84MAPKAPK30.79848702
85MARK30.78887288
86ERBB30.78387265
87HCK0.77519724
88DMPK0.77216636
89JAK20.76937309
90LMTK20.76185114
91BMPR1B0.75882114
92OBSCN0.75397669
93EEF2K0.74673289
94CDC42BPA0.74506293
95TAOK30.74491665
96CHUK0.73690305
97RPS6KA40.72982038
98YES10.71972121
99BCKDK0.65581226
100LYN0.65100877
101MAP3K130.64805323
102MAPK120.64368056
103MATK0.63849434
104HIPK20.60201246
105PRKD20.58484045
106STK110.58096191
107MAPK110.57294656
108MAP3K10.56870715
109PDPK10.56452933
110IGF1R0.56166904
111PAK20.55890205
112PRKAA20.55074681
113SIK20.53321283
114ABL10.52389256
115PIM10.52215183
116WNK10.51804822
117PRKCQ0.51670928
118OXSR10.50244746
119PRKCH0.50179331
120ILK0.49771554
121RPS6KA60.49666850
122EIF2AK20.48916172
123PRKG20.48450735
124GRK50.47208775
125STK240.46497287
126MAPK40.45306893
127MET0.44821023
128BMPR20.44305325
129WNK40.43292232
130MAP3K20.43181759
131PRPF4B0.42226933
132MAP3K110.41749382
133MELK0.40905351
134SGK20.40348255
135STK380.39428599
136MAPKAPK20.37583845
137PRKCD0.33942824
138MAP4K20.30812305
139MAPK130.30775868
140CAMKK10.30710547

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053203.00878810
2Type I diabetes mellitus_Homo sapiens_hsa049402.58903742
3Asthma_Homo sapiens_hsa053102.51852034
4Staphylococcus aureus infection_Homo sapiens_hsa051502.26909064
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10043978
6Primary immunodeficiency_Homo sapiens_hsa053402.08533994
7Leishmaniasis_Homo sapiens_hsa051402.01251833
8Other glycan degradation_Homo sapiens_hsa005111.97614833
9Malaria_Homo sapiens_hsa051441.96795265
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.71582474
11Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66279015
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.63793318
13Hematopoietic cell lineage_Homo sapiens_hsa046401.61983219
14Osteoclast differentiation_Homo sapiens_hsa043801.60186477
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53602829
16Complement and coagulation cascades_Homo sapiens_hsa046101.51497565
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49923396
18ECM-receptor interaction_Homo sapiens_hsa045121.46463805
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.45912952
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45110733
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.45029558
22Lysosome_Homo sapiens_hsa041421.45024760
23Nitrogen metabolism_Homo sapiens_hsa009101.43523742
24Measles_Homo sapiens_hsa051621.37759674
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.36928603
26Fatty acid degradation_Homo sapiens_hsa000711.33724548
27Toxoplasmosis_Homo sapiens_hsa051451.33110217
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.32954752
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.31201381
30Chemical carcinogenesis_Homo sapiens_hsa052041.29146615
31Pertussis_Homo sapiens_hsa051331.28656586
32Caffeine metabolism_Homo sapiens_hsa002321.28615589
33Starch and sucrose metabolism_Homo sapiens_hsa005001.28308460
34B cell receptor signaling pathway_Homo sapiens_hsa046621.27826341
35Legionellosis_Homo sapiens_hsa051341.27800978
36Focal adhesion_Homo sapiens_hsa045101.23246492
37Rheumatoid arthritis_Homo sapiens_hsa053231.22624008
38TNF signaling pathway_Homo sapiens_hsa046681.22508887
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21332404
40Antigen processing and presentation_Homo sapiens_hsa046121.17241922
41PPAR signaling pathway_Homo sapiens_hsa033201.16882662
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15017323
43Platelet activation_Homo sapiens_hsa046111.13592873
44ABC transporters_Homo sapiens_hsa020101.09147555
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09052900
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08507970
47Insulin resistance_Homo sapiens_hsa049311.07899776
48Graft-versus-host disease_Homo sapiens_hsa053321.06357999
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04149538
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04094586
51Linoleic acid metabolism_Homo sapiens_hsa005911.01711303
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01658440
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98865053
54Tuberculosis_Homo sapiens_hsa051520.95564586
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93063292
56Amoebiasis_Homo sapiens_hsa051460.92547556
57Peroxisome_Homo sapiens_hsa041460.91240834
58Fatty acid metabolism_Homo sapiens_hsa012120.90784951
59Dorso-ventral axis formation_Homo sapiens_hsa043200.90645222
60Adherens junction_Homo sapiens_hsa045200.90413743
61Small cell lung cancer_Homo sapiens_hsa052220.89943033
62Ether lipid metabolism_Homo sapiens_hsa005650.89521688
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87052519
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86787210
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.85478852
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85134045
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.84601992
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.82501789
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82455738
70T cell receptor signaling pathway_Homo sapiens_hsa046600.81842681
71Acute myeloid leukemia_Homo sapiens_hsa052210.81473212
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81250630
73Proteoglycans in cancer_Homo sapiens_hsa052050.81026098
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80120680
75Arachidonic acid metabolism_Homo sapiens_hsa005900.78806761
76Hepatitis B_Homo sapiens_hsa051610.78220227
77Influenza A_Homo sapiens_hsa051640.77538072
78Chronic myeloid leukemia_Homo sapiens_hsa052200.76431190
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76202039
80beta-Alanine metabolism_Homo sapiens_hsa004100.75796694
81Viral myocarditis_Homo sapiens_hsa054160.75073930
82Fatty acid biosynthesis_Homo sapiens_hsa000610.74364541
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73913082
84Histidine metabolism_Homo sapiens_hsa003400.73409728
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70980753
86African trypanosomiasis_Homo sapiens_hsa051430.70685849
87Propanoate metabolism_Homo sapiens_hsa006400.70351395
88Prostate cancer_Homo sapiens_hsa052150.69677015
89Herpes simplex infection_Homo sapiens_hsa051680.68659276
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67620263
91Apoptosis_Homo sapiens_hsa042100.67489980
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67360593
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65088060
94Salmonella infection_Homo sapiens_hsa051320.62442251
95Phagosome_Homo sapiens_hsa041450.62077771
96Protein digestion and absorption_Homo sapiens_hsa049740.61718503
97Tryptophan metabolism_Homo sapiens_hsa003800.60502543
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59605482
99Pancreatic cancer_Homo sapiens_hsa052120.58656167
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58478095
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58379489
102Shigellosis_Homo sapiens_hsa051310.55899950
103Chemokine signaling pathway_Homo sapiens_hsa040620.55773791
104FoxO signaling pathway_Homo sapiens_hsa040680.53484801
105Hepatitis C_Homo sapiens_hsa051600.52955462
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52292830
107Sulfur metabolism_Homo sapiens_hsa009200.50034694
108Glutathione metabolism_Homo sapiens_hsa004800.49614234
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49332640
110Galactose metabolism_Homo sapiens_hsa000520.48618102
111Retinol metabolism_Homo sapiens_hsa008300.47911178
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.47851521
113Prolactin signaling pathway_Homo sapiens_hsa049170.47674309
114Allograft rejection_Homo sapiens_hsa053300.47379114
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47166100
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.46611956
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.45841174
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45324638
119Sphingolipid metabolism_Homo sapiens_hsa006000.44992742
120Collecting duct acid secretion_Homo sapiens_hsa049660.43555218
121Type II diabetes mellitus_Homo sapiens_hsa049300.41341836
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40053529
123Glycerolipid metabolism_Homo sapiens_hsa005610.39074393
124Phototransduction_Homo sapiens_hsa047440.36651702
125Ovarian steroidogenesis_Homo sapiens_hsa049130.34084281
126Regulation of autophagy_Homo sapiens_hsa041400.30747282
127Systemic lupus erythematosus_Homo sapiens_hsa053220.29874637
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27944207
129Epstein-Barr virus infection_Homo sapiens_hsa051690.27905566
130Mineral absorption_Homo sapiens_hsa049780.26951490
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.26346472
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24778193
133VEGF signaling pathway_Homo sapiens_hsa043700.20476470

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