MRAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid homeostasis (GO:0055089)7.39691146
2estrogen biosynthetic process (GO:0006703)6.89989086
3diacylglycerol metabolic process (GO:0046339)6.30091869
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.24541100
5L-phenylalanine catabolic process (GO:0006559)6.24541100
6progesterone metabolic process (GO:0042448)6.06887804
7androgen biosynthetic process (GO:0006702)6.06821275
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.04835173
9L-phenylalanine metabolic process (GO:0006558)6.04835173
10triglyceride biosynthetic process (GO:0019432)6.02017765
11alpha-linolenic acid metabolic process (GO:0036109)5.93032371
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.92409389
13response to phenylpropanoid (GO:0080184)5.78724297
14neutral lipid biosynthetic process (GO:0046460)5.74879460
15acylglycerol biosynthetic process (GO:0046463)5.74879460
16cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.51226898
17glucocorticoid biosynthetic process (GO:0006704)5.45312753
18aromatic amino acid family catabolic process (GO:0009074)5.42165135
19complement activation, alternative pathway (GO:0006957)5.29569659
20white fat cell differentiation (GO:0050872)5.28500117
21fatty-acyl-CoA metabolic process (GO:0035337)5.25262274
22glycerolipid catabolic process (GO:0046503)5.24048079
23* brown fat cell differentiation (GO:0050873)5.19083503
24glyoxylate metabolic process (GO:0046487)5.16217676
25NADH metabolic process (GO:0006734)5.14929140
26bile acid biosynthetic process (GO:0006699)5.10082582
27regulation of triglyceride catabolic process (GO:0010896)5.08357412
28sulfur amino acid catabolic process (GO:0000098)5.06862411
29cysteine metabolic process (GO:0006534)4.96346157
30lipid particle organization (GO:0034389)4.89901858
31plasma lipoprotein particle clearance (GO:0034381)4.89653118
32lipid storage (GO:0019915)4.88678126
33acylglycerol homeostasis (GO:0055090)4.87241131
34triglyceride homeostasis (GO:0070328)4.87241131
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86739942
36long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.86734595
37low-density lipoprotein particle clearance (GO:0034383)4.84885089
38high-density lipoprotein particle remodeling (GO:0034375)4.81694477
39CDP-diacylglycerol biosynthetic process (GO:0016024)4.81391395
40urea cycle (GO:0000050)4.73042071
41urea metabolic process (GO:0019627)4.73042071
42tryptophan catabolic process (GO:0006569)4.72616361
43indole-containing compound catabolic process (GO:0042436)4.72616361
44indolalkylamine catabolic process (GO:0046218)4.72616361
45cellular response to epinephrine stimulus (GO:0071872)4.72560601
46regulation of sequestering of triglyceride (GO:0010889)4.70928839
47kynurenine metabolic process (GO:0070189)4.67909045
48C21-steroid hormone biosynthetic process (GO:0006700)4.66294869
49regulation of protein activation cascade (GO:2000257)4.59577812
50acyl-CoA metabolic process (GO:0006637)4.56465481
51thioester metabolic process (GO:0035383)4.56465481
52positive regulation of fatty acid beta-oxidation (GO:0032000)4.54384863
53negative regulation of fibrinolysis (GO:0051918)4.53346259
54triglyceride catabolic process (GO:0019433)4.49783192
55valine metabolic process (GO:0006573)4.49465284
56cellular response to cadmium ion (GO:0071276)4.49243627
57positive regulation of lipid storage (GO:0010884)4.46521217
58peptidyl-glutamic acid carboxylation (GO:0017187)4.44849713
59protein carboxylation (GO:0018214)4.44849713
60CDP-diacylglycerol metabolic process (GO:0046341)4.44499201
61retinol metabolic process (GO:0042572)4.44273603
62tryptophan metabolic process (GO:0006568)4.43485409
63C21-steroid hormone metabolic process (GO:0008207)4.42923691
64bile acid metabolic process (GO:0008206)4.39536529
65acylglycerol catabolic process (GO:0046464)4.38718224
66neutral lipid catabolic process (GO:0046461)4.38718224
67nitrogen cycle metabolic process (GO:0071941)4.38669021
68lysine catabolic process (GO:0006554)4.38606463
69lysine metabolic process (GO:0006553)4.38606463
70fatty acid beta-oxidation (GO:0006635)4.35362216
71response to follicle-stimulating hormone (GO:0032354)4.35005412
72acylglycerol metabolic process (GO:0006639)4.34838407
73regulation of complement activation (GO:0030449)4.32702540
74plasma lipoprotein particle remodeling (GO:0034369)4.32317557
75protein-lipid complex remodeling (GO:0034368)4.32317557
76macromolecular complex remodeling (GO:0034367)4.32317557
77reverse cholesterol transport (GO:0043691)4.29677095
78acetyl-CoA metabolic process (GO:0006084)4.29586584
79regulation of fibrinolysis (GO:0051917)4.29078020
80neutral lipid metabolic process (GO:0006638)4.28820259
81serine family amino acid catabolic process (GO:0009071)4.28362034
82amino-acid betaine metabolic process (GO:0006577)4.28238792
83regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.24952116
84positive regulation of lipid catabolic process (GO:0050996)4.24705511
85primary alcohol metabolic process (GO:0034308)4.24397086
86regulation of triglyceride biosynthetic process (GO:0010866)4.22533310
87negative regulation of macrophage differentiation (GO:0045650)4.21065689
88positive regulation of glomerulus development (GO:0090193)4.20106043
89fatty acid oxidation (GO:0019395)4.19138959
90positive regulation of fatty acid oxidation (GO:0046321)4.15965135
91glucocorticoid metabolic process (GO:0008211)4.15354495
92negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.14248145
93lipid oxidation (GO:0034440)4.10793494
94homocysteine metabolic process (GO:0050667)4.05307396
95response to epinephrine (GO:0071871)4.04980297
96tyrosine metabolic process (GO:0006570)4.03902476
97regulation of cholesterol esterification (GO:0010872)4.03550519
98fatty acid catabolic process (GO:0009062)4.02117051
99biotin metabolic process (GO:0006768)3.99526741
100alpha-amino acid catabolic process (GO:1901606)3.96603106
101fatty acid transmembrane transport (GO:1902001)3.96046466
102ethanol oxidation (GO:0006069)3.93049917
103aromatic amino acid family metabolic process (GO:0009072)3.92322738
104long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.91891477
105phospholipid efflux (GO:0033700)3.90206452
106negative regulation of lipase activity (GO:0060192)3.89804631
1072-oxoglutarate metabolic process (GO:0006103)3.85582367
108short-chain fatty acid metabolic process (GO:0046459)3.84383650
109glycerol metabolic process (GO:0006071)3.82900757
110tricarboxylic acid metabolic process (GO:0072350)3.82336138
111cellular ketone body metabolic process (GO:0046950)3.82086630
112monocarboxylic acid catabolic process (GO:0072329)3.79465356
113branched-chain amino acid catabolic process (GO:0009083)3.79369478
114oxaloacetate metabolic process (GO:0006107)3.78911305
115positive regulation of cholesterol efflux (GO:0010875)3.78183976
116epoxygenase P450 pathway (GO:0019373)3.74809512
117cellular amino acid catabolic process (GO:0009063)3.74469958
118coenzyme catabolic process (GO:0009109)3.74081312
119regulation of fatty acid beta-oxidation (GO:0031998)3.74059402
120benzene-containing compound metabolic process (GO:0042537)3.72234959
121cellular response to lithium ion (GO:0071285)3.68027754
122transcytosis (GO:0045056)3.66697661
123positive regulation of triglyceride metabolic process (GO:0090208)3.65648459
124cellular response to antibiotic (GO:0071236)3.64978205
125cholesterol efflux (GO:0033344)3.63841541
126organic acid catabolic process (GO:0016054)3.59770896
127carboxylic acid catabolic process (GO:0046395)3.59770896
128plasma lipoprotein particle assembly (GO:0034377)3.59378894
129branched-chain amino acid metabolic process (GO:0009081)3.58224483
130phospholipid homeostasis (GO:0055091)3.58222186
131regulation of triglyceride metabolic process (GO:0090207)3.56579244
132phosphatidic acid biosynthetic process (GO:0006654)3.55577385
133phosphatidic acid metabolic process (GO:0046473)3.55577385
134Leydig cell differentiation (GO:0033327)3.55414542
135regulation of cAMP-dependent protein kinase activity (GO:2000479)3.55311102
136protein heterotrimerization (GO:0070208)3.55074429
137regulation of cholesterol storage (GO:0010885)3.54557919
138intracellular lipid transport (GO:0032365)3.54554002
139carnitine metabolic process (GO:0009437)3.54090847
140cholesterol homeostasis (GO:0042632)3.53326573
141negative regulation of cholesterol transport (GO:0032375)3.52833930
142negative regulation of sterol transport (GO:0032372)3.52833930
143very-low-density lipoprotein particle assembly (GO:0034379)3.52043666
144positive regulation of triglyceride lipase activity (GO:0061365)3.51825301
145positive regulation of lipoprotein lipase activity (GO:0051006)3.51825301
146alditol metabolic process (GO:0019400)3.51440223
147response to nitrosative stress (GO:0051409)3.50932602
148regulation of glycogen (starch) synthase activity (GO:2000465)3.50913581
149sterol homeostasis (GO:0055092)3.47936313
150positive regulation of fatty acid metabolic process (GO:0045923)3.45993364
151carnitine shuttle (GO:0006853)3.45825222
152triglyceride metabolic process (GO:0006641)3.45690582
153fatty-acyl-CoA biosynthetic process (GO:0046949)3.45621741
154cytolysis (GO:0019835)3.44248899
155plasma lipoprotein particle organization (GO:0071827)3.43812151
156thioester biosynthetic process (GO:0035384)3.43446020
157acyl-CoA biosynthetic process (GO:0071616)3.43446020
158polyol transport (GO:0015791)3.42396422
159positive regulation of triglyceride biosynthetic process (GO:0010867)3.42264737
160cellular response to gonadotropin stimulus (GO:0071371)3.41638114
161positive regulation of cholesterol transport (GO:0032376)3.41152912
162positive regulation of sterol transport (GO:0032373)3.41152912
163regulation of lipid storage (GO:0010883)3.36945169
164response to vitamin E (GO:0033197)3.34848701
165response to dietary excess (GO:0002021)3.29439561
166response to hydroperoxide (GO:0033194)3.27682704
167L-serine transport (GO:0015825)3.25402363
168hormone biosynthetic process (GO:0042446)3.24130651
169regulation of macrophage derived foam cell differentiation (GO:0010743)3.22043665
170linoleic acid metabolic process (GO:0043651)3.17467675
171peroxisome fission (GO:0016559)3.15286993
172negative regulation of metanephros development (GO:0072217)3.13520829
173estrogen metabolic process (GO:0008210)3.11380941
174doxorubicin metabolic process (GO:0044598)3.07328745

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.43105871
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.49646720
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.48588086
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.94198023
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.71404339
6EGR1_23403033_ChIP-Seq_LIVER_Mouse5.65465005
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.36720470
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.74456709
9* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.31536821
10* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.08889388
11* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.78575026
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.31124845
13* CLOCK_20551151_ChIP-Seq_293T_Human2.73980669
14IGF1R_20145208_ChIP-Seq_DFB_Human2.67255210
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01820425
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5290797
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93177442
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.90245595
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82541040
20GATA1_22025678_ChIP-Seq_K562_Human1.61876183
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.54065175
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.50374291
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.45236305
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.45197230
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.37324854
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35920698
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29422288
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26765474
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26346682
30* HNF4A_19822575_ChIP-Seq_HepG2_Human1.24018538
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21957064
32GBX2_23144817_ChIP-Seq_PC3_Human1.20480234
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20463240
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17218947
35* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.11316071
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.10910962
37ZNF263_19887448_ChIP-Seq_K562_Human1.08814304
38HTT_18923047_ChIP-ChIP_STHdh_Human1.07703587
39SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07603641
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06051249
41RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98145508
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95293030
43TRIM28_21343339_ChIP-Seq_HEK293_Human0.92503932
44FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92146702
45SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90489394
46VDR_22108803_ChIP-Seq_LS180_Human0.90462356
47PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90069860
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89641068
49SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86921582
50PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86588658
51PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85778097
52LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83188593
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82370652
54ESR1_20079471_ChIP-ChIP_T-47D_Human0.82297701
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80721595
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80693526
57EOMES_21245162_ChIP-Seq_HESCs_Human0.79935131
58ETS1_20019798_ChIP-Seq_JURKAT_Human0.79465698
59AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79343988
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.79277796
61E2F1_18555785_ChIP-Seq_MESCs_Mouse0.78890080
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78844994
63NOTCH1_21737748_ChIP-Seq_TLL_Human0.78091059
64IRF8_22096565_ChIP-ChIP_GC-B_Human0.77689693
65SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77520464
66ESR2_21235772_ChIP-Seq_MCF-7_Human0.77149803
67GATA4_25053715_ChIP-Seq_YYC3_Human0.76905515
68ELF1_17652178_ChIP-ChIP_JURKAT_Human0.76358138
69ESR1_15608294_ChIP-ChIP_MCF-7_Human0.74799662
70SA1_22415368_ChIP-Seq_MEFs_Mouse0.74602384
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.73948317
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73657084
73NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72579550
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72579550
75CDX2_19796622_ChIP-Seq_MESCs_Mouse0.72319680
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.68640081
77FOXO3_23340844_ChIP-Seq_DLD1_Human0.68484816
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.68283888
79GATA4_21415370_ChIP-Seq_HL-1_Mouse0.67905911
80GATA1_19941826_ChIP-Seq_K562_Human0.67214303
81* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67193232
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.67010547
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66617636
84TP63_17297297_ChIP-ChIP_HaCaT_Human0.66503671
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.66455506
86TBX20_22328084_ChIP-Seq_HEART_Mouse0.65434672
87TBX20_22080862_ChIP-Seq_HEART_Mouse0.65434672
88AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64952247
89FLI1_27457419_Chip-Seq_LIVER_Mouse0.64332126
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.63603985
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.63603985
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.63109047
93* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.60611176
94RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60534346
95MYC_18555785_ChIP-Seq_MESCs_Mouse0.60309993
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59634641
97TCF4_22108803_ChIP-Seq_LS180_Human0.59402086
98RARA_24833708_ChIP-Seq_LIVER_Mouse0.59007469
99* CEBPB_22108803_ChIP-Seq_LS180_Human0.58065633
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.57316295
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.57268824
102MYC_18358816_ChIP-ChIP_MESCs_Mouse0.57065679
103AR_25329375_ChIP-Seq_VCAP_Human0.56312222
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.56196062
105NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.56011968
106HIF1A_21447827_ChIP-Seq_MCF-7_Human0.55704685
107GATA2_19941826_ChIP-Seq_K562_Human0.55356093
108CJUN_26792858_Chip-Seq_BT549_Human0.54853596
109CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.54678190
110LXR_22292898_ChIP-Seq_THP-1_Human0.54101025
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.54033584
112GATA3_21878914_ChIP-Seq_MCF-7_Human0.53549107
113SOX11_22085726_ChIP-Seq_ESNs_Mouse0.53529053
114RARB_24833708_ChIP-Seq_LIVER_Mouse0.53280079
115NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.53145336
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.52977297
117EGR1_19032775_ChIP-ChIP_M12_Human0.52771803
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.52664793
119FOXA1_25552417_ChIP-Seq_VCAP_Human0.52001978
120ESR1_21235772_ChIP-Seq_MCF-7_Human0.51320653
121P300_19829295_ChIP-Seq_ESCs_Human0.51255578
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.50609849
123KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.50605912
124KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.50605912
125KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.50605912
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.50345965
127LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.49881159
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.48937414
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.48857503
130NELFA_20434984_ChIP-Seq_ESCs_Mouse0.48662958
131GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.48525543
132BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.47873430
133BCAT_22108803_ChIP-Seq_LS180_Human0.47503586
134CDX2_20551321_ChIP-Seq_CACO-2_Human0.47218011
135GATA3_24758297_ChIP-Seq_MCF-7_Human0.45540463
136PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.45532737
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.45448223
138SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45410131
139FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.44659316
140* AR_20517297_ChIP-Seq_VCAP_Human0.43223334
141SOX2_20726797_ChIP-Seq_SW620_Human0.42246838
142CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.42054945
143ESET_19884257_ChIP-Seq_ESCs_Mouse0.41226693
144GATA2_21666600_ChIP-Seq_HMVEC_Human0.41073040
145KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.40311169
146CBP_21632823_ChIP-Seq_H3396_Human0.40078830
147RACK7_27058665_Chip-Seq_MCF-7_Human0.38224107
148GATA1_19941827_ChIP-Seq_MEL_Mouse0.38130104
149* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.37702851
150ATF3_27146783_Chip-Seq_COLON_Human0.37690495
151* ERG_20517297_ChIP-Seq_VCAP_Human0.36517503
152GATA6_25053715_ChIP-Seq_YYC3_Human0.36509199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.15133525
2MP0005360_urolithiasis6.18133450
3MP0005365_abnormal_bile_salt5.58889037
4MP0005085_abnormal_gallbladder_physiolo5.14624502
5MP0008875_abnormal_xenobiotic_pharmacok4.15656305
6MP0010329_abnormal_lipoprotein_level4.00434989
7MP0005670_abnormal_white_adipose3.55339272
8MP0003806_abnormal_nucleotide_metabolis3.32566855
9MP0003252_abnormal_bile_duct3.11990634
10MP0003191_abnormal_cellular_cholesterol2.77275341
11MP0009840_abnormal_foam_cell2.73346970
12MP0004130_abnormal_muscle_cell2.56336857
13MP0003195_calcinosis2.54378198
14MP0005332_abnormal_amino_acid2.51234369
15MP0002118_abnormal_lipid_homeostasis2.50140224
16MP0005666_abnormal_adipose_tissue2.45075691
17MP0000609_abnormal_liver_physiology2.31718690
18MP0005083_abnormal_biliary_tract2.18517609
19MP0004185_abnormal_adipocyte_glucose2.09592893
20MP0001666_abnormal_nutrient_absorption2.02147888
21MP0005319_abnormal_enzyme/_coenzyme1.92680551
22MP0003186_abnormal_redox_activity1.87007656
23MP0002971_abnormal_brown_adipose1.78213462
24MP0005584_abnormal_enzyme/coenzyme_acti1.71848368
25MP0004019_abnormal_vitamin_homeostasis1.69628362
26MP0002837_dystrophic_cardiac_calcinosis1.61575666
27MP0001764_abnormal_homeostasis1.61279407
28MP0005375_adipose_tissue_phenotype1.59758959
29MP0003705_abnormal_hypodermis_morpholog1.57371039
30MP0003828_pulmonary_edema1.54021720
31MP0003950_abnormal_plasma_membrane1.49484876
32MP0005334_abnormal_fat_pad1.49014214
33MP0003941_abnormal_skin_development1.48715155
34MP0003011_delayed_dark_adaptation1.46458601
35MP0002876_abnormal_thyroid_physiology1.41224116
36MP0005379_endocrine/exocrine_gland_phen1.40330495
37MP0006036_abnormal_mitochondrial_physio1.30304595
38MP0005647_abnormal_sex_gland1.29845053
39MP0009780_abnormal_chondrocyte_physiolo1.29398279
40MP0005535_abnormal_body_temperature1.28805440
41MP0009643_abnormal_urine_homeostasis1.28736876
42MP0002638_abnormal_pupillary_reflex1.27031532
43MP0001661_extended_life_span1.26582588
44MP0002138_abnormal_hepatobiliary_system1.26463671
45MP0009115_abnormal_fat_cell1.26130491
46MP0003656_abnormal_erythrocyte_physiolo1.26076966
47MP0003868_abnormal_feces_composition1.25235324
48MP0008438_abnormal_cutaneous_collagen1.23956836
49MP0005451_abnormal_body_composition1.17486276
50MP0000598_abnormal_liver_morphology1.17322264
51MP0002078_abnormal_glucose_homeostasis1.14525137
52MP0009697_abnormal_copulation1.14443672
53MP0002970_abnormal_white_adipose1.09430943
54MP0004272_abnormal_basement_membrane1.04840332
55MP0002254_reproductive_system_inflammat1.03393119
56MP0009763_increased_sensitivity_to1.02329191
57MP0005448_abnormal_energy_balance1.00120091
58MP0005167_abnormal_blood-brain_barrier0.98965864
59MP0000639_abnormal_adrenal_gland0.98339670
60MP0004215_abnormal_myocardial_fiber0.96792993
61MP0001879_abnormal_lymphatic_vessel0.96710517
62MP0003948_abnormal_gas_homeostasis0.93093827
63MP0005636_abnormal_mineral_homeostasis0.91633686
64MP0004782_abnormal_surfactant_physiolog0.90546049
65MP0000003_abnormal_adipose_tissue0.90052737
66MP0000604_amyloidosis0.88463277
67MP0003690_abnormal_glial_cell0.88081541
68MP0009642_abnormal_blood_homeostasis0.85477139
69MP0009764_decreased_sensitivity_to0.85366589
70MP0010368_abnormal_lymphatic_system0.85195537
71MP0003724_increased_susceptibility_to0.84285563
72MP0005376_homeostasis/metabolism_phenot0.83320863
73MP0001177_atelectasis0.81718608
74MP0001756_abnormal_urination0.80443186
75MP0008469_abnormal_protein_level0.79736989
76MP0002909_abnormal_adrenal_gland0.78772165
77MP0000013_abnormal_adipose_tissue0.77927115
78MP0008995_early_reproductive_senescence0.77912370
79MP0003959_abnormal_lean_body0.75594141
80MP0004147_increased_porphyrin_level0.73839962
81MP0000751_myopathy0.73334067
82MP0009703_decreased_birth_body0.70457859
83MP0001881_abnormal_mammary_gland0.70376703
84MP0005266_abnormal_metabolism0.70149081
85MP0005503_abnormal_tendon_morphology0.69645281
86MP0000230_abnormal_systemic_arterial0.69375269
87MP0006035_abnormal_mitochondrial_morpho0.69162838
88MP0005275_abnormal_skin_tensile0.68933102
89MP0003953_abnormal_hormone_level0.68619200
90MP0003567_abnormal_fetal_cardiomyocyte0.67649087
91MP0005452_abnormal_adipose_tissue0.67128318
92MP0008775_abnormal_heart_ventricle0.64572516
93MP0009765_abnormal_xenobiotic_induced0.64530707
94MP0006138_congestive_heart_failure0.64443237
95MP0002938_white_spotting0.64048411
96MP0005187_abnormal_penis_morphology0.62956503
97MP0001984_abnormal_olfaction0.61405951
98MP0003646_muscle_fatigue0.60912734
99MP0002108_abnormal_muscle_morphology0.60182089
100MP0002796_impaired_skin_barrier0.59766107
101MP0005164_abnormal_response_to0.59041982
102MP0002160_abnormal_reproductive_system0.58652811
103MP0001944_abnormal_pancreas_morphology0.57292148
104MP0000372_irregular_coat_pigmentation0.56056975
105MP0003315_abnormal_perineum_morphology0.54677137
106MP0001727_abnormal_embryo_implantation0.54074991
107MP0005330_cardiomyopathy0.54003072
108MP0002069_abnormal_eating/drinking_beha0.53865549
109MP0000749_muscle_degeneration0.52085188
110MP0003221_abnormal_cardiomyocyte_apopto0.50680845
111MP0004087_abnormal_muscle_fiber0.49561603
112MP0005385_cardiovascular_system_phenoty0.49194786
113MP0001544_abnormal_cardiovascular_syste0.49194786
114MP0002060_abnormal_skin_morphology0.49146840
115MP0009672_abnormal_birth_weight0.48747671
116MP0002168_other_aberrant_phenotype0.48404150
117MP0006276_abnormal_autonomic_nervous0.47875867
118MP0000343_altered_response_to0.47775030
119MP0004883_abnormal_blood_vessel0.47606464
120MP0000767_abnormal_smooth_muscle0.47600337
121MP0000249_abnormal_blood_vessel0.46877113
122MP0009053_abnormal_anal_canal0.46817425
123MP0005084_abnormal_gallbladder_morpholo0.46689158
124MP0005395_other_phenotype0.46290855
125MP0002136_abnormal_kidney_physiology0.45707859
126MP0008872_abnormal_physiological_respon0.43907493
127MP0003279_aneurysm0.42925477
128MP0000759_abnormal_skeletal_muscle0.42879317
129MP0003329_amyloid_beta_deposits0.42633205
130MP0005408_hypopigmentation0.41766044
131MP0001501_abnormal_sleep_pattern0.41677867
132MP0005220_abnormal_exocrine_pancreas0.39794668
133MP0001853_heart_inflammation0.39235147
134MP0005595_abnormal_vascular_smooth0.39026168
135MP0002269_muscular_atrophy0.38802702
136MP0002332_abnormal_exercise_endurance0.37837293

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.07105402
2Xanthomatosis (HP:0000991)6.03861863
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.91484435
4Intrahepatic cholestasis (HP:0001406)5.79582826
5Hyperlipoproteinemia (HP:0010980)5.64348387
6Complement deficiency (HP:0004431)5.57039597
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.16579922
8Hypobetalipoproteinemia (HP:0003563)5.15453344
9Prolonged partial thromboplastin time (HP:0003645)5.09289277
10Increased serum pyruvate (HP:0003542)4.99697895
11Hyperglycinuria (HP:0003108)4.96013904
12Epidermoid cyst (HP:0200040)4.90729612
13Renal salt wasting (HP:0000127)4.78395577
14Hyperammonemia (HP:0001987)4.68665920
15Abnormality of glycine metabolism (HP:0010895)4.66174566
16Abnormality of serine family amino acid metabolism (HP:0010894)4.66174566
17Hypoglycemic coma (HP:0001325)4.57371050
18Hyperglycinemia (HP:0002154)4.53015124
19Hypolipoproteinemia (HP:0010981)4.47553058
20Hypoalphalipoproteinemia (HP:0003233)4.44020917
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.42700017
22Ketosis (HP:0001946)4.42482508
23Abnormal sex determination (HP:0012244)4.34435592
24Sex reversal (HP:0012245)4.34435592
25Abnormality of glycolysis (HP:0004366)4.27396948
26Reduced antithrombin III activity (HP:0001976)4.14792561
27Abnormality of fatty-acid metabolism (HP:0004359)4.09955068
28Abnormality of complement system (HP:0005339)4.00621913
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.82833394
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.81624161
31Abnormality of alanine metabolism (HP:0010916)3.75980540
32Hyperalaninemia (HP:0003348)3.75980540
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.75980540
34Abnormality of the common coagulation pathway (HP:0010990)3.74035060
35Joint hemorrhage (HP:0005261)3.72452635
36Hypercholesterolemia (HP:0003124)3.54288501
37Ketoacidosis (HP:0001993)3.50643882
38Abnormality of aspartate family amino acid metabolism (HP:0010899)3.44969498
39Growth hormone excess (HP:0000845)3.36845746
40Abnormality of sulfur amino acid metabolism (HP:0004339)3.33914510
41Insulin-resistant diabetes mellitus (HP:0000831)3.32804978
42Abnormality of methionine metabolism (HP:0010901)3.31752322
43Dicarboxylic aciduria (HP:0003215)3.25250841
44Abnormality of dicarboxylic acid metabolism (HP:0010995)3.25250841
45Fat malabsorption (HP:0002630)3.22782219
46Myocardial infarction (HP:0001658)3.20091219
47Skin nodule (HP:0200036)3.18459134
48Abnormality of the intrinsic pathway (HP:0010989)3.16138700
49Clitoromegaly (HP:0000057)3.15885391
50Abnormality of serum amino acid levels (HP:0003112)3.14179754
51Hypertriglyceridemia (HP:0002155)3.09855123
52Tetraparesis (HP:0002273)2.96842821
53Oligomenorrhea (HP:0000876)2.89467094
54Hyperpituitarism (HP:0010514)2.86511732
55Hyperbilirubinemia (HP:0002904)2.84823135
56Nausea (HP:0002018)2.84013799
57Metabolic acidosis (HP:0001942)2.83461889
58Lethargy (HP:0001254)2.80416295
59Potter facies (HP:0002009)2.78438753
60Facial shape deformation (HP:0011334)2.78438753
61Cerebral edema (HP:0002181)2.74182194
62Polyphagia (HP:0002591)2.73941341
63Hepatocellular carcinoma (HP:0001402)2.69376572
64Abnormal gallbladder physiology (HP:0012438)2.69180840
65Cholecystitis (HP:0001082)2.69180840
66Hydroxyprolinuria (HP:0003080)2.66923258
67Abnormality of proline metabolism (HP:0010907)2.66923258
68Long foot (HP:0001833)2.65672260
69Difficulty running (HP:0009046)2.63314811
70Abnormality of pyrimidine metabolism (HP:0004353)2.62543786
71Systemic lupus erythematosus (HP:0002725)2.61722271
72Delayed CNS myelination (HP:0002188)2.59356926
73Abnormality of nucleobase metabolism (HP:0010932)2.59350478
74Bone cyst (HP:0012062)2.59169002
75Abnormal cartilage morphology (HP:0002763)2.58459640
76Abnormality of purine metabolism (HP:0004352)2.57753824
77Cholelithiasis (HP:0001081)2.55569012
78Abnormal gallbladder morphology (HP:0012437)2.55358597
79Increased variability in muscle fiber diameter (HP:0003557)2.54830499
80Generalized aminoaciduria (HP:0002909)2.52928834
81Accelerated skeletal maturation (HP:0005616)2.50176336
82Spontaneous abortion (HP:0005268)2.49642666
83Conjugated hyperbilirubinemia (HP:0002908)2.47522529
84Acanthosis nigricans (HP:0000956)2.45851864
85Myoglobinuria (HP:0002913)2.45592064
86Hepatocellular necrosis (HP:0001404)2.45234549
87Pancreatitis (HP:0001733)2.45075298
88Neonatal onset (HP:0003623)2.44292617
89Abnormal hemoglobin (HP:0011902)2.43433727
90Steatorrhea (HP:0002570)2.43221645
91Hyperaldosteronism (HP:0000859)2.42919528
92Vomiting (HP:0002013)2.40336815
93Hypoglycemic seizures (HP:0002173)2.38658152
94Enlarged penis (HP:0000040)2.37487775
95Hypochromic microcytic anemia (HP:0004840)2.36493104
96CNS demyelination (HP:0007305)2.35886283
97Subcapsular cataract (HP:0000523)2.33590712
98Hemorrhage of the eye (HP:0011885)2.30881864
99Ileus (HP:0002595)2.29869243
100Brushfield spots (HP:0001088)2.29763079
101Acanthocytosis (HP:0001927)2.25909032
102Testicular atrophy (HP:0000029)2.24744917
103Amyloidosis (HP:0011034)2.22873577
104Renal cortical cysts (HP:0000803)2.22391792
105Acute encephalopathy (HP:0006846)2.21781269
106Acute necrotizing encephalopathy (HP:0006965)2.14966512
107Secondary amenorrhea (HP:0000869)2.11973572
108Abnormality of the clitoris (HP:0000056)2.11764070
109Hyperglycemia (HP:0003074)2.11751311
110Abnormal eating behavior (HP:0100738)2.11478430
111Renal Fanconi syndrome (HP:0001994)2.10932963
112Multiple enchondromatosis (HP:0005701)2.10635871
113Decreased activity of mitochondrial respiratory chain (HP:0008972)2.10416036
114Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.10416036
115Spastic diplegia (HP:0001264)2.06348370
116Prominent supraorbital ridges (HP:0000336)2.05935492
117Rhabdomyolysis (HP:0003201)2.05659192
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03697436
119Abnormal protein N-linked glycosylation (HP:0012347)2.03697436
120Abnormal protein glycosylation (HP:0012346)2.03697436
121Abnormal glycosylation (HP:0012345)2.03697436
1223-Methylglutaconic aciduria (HP:0003535)2.03456683
123Abnormality of skeletal muscle fiber size (HP:0012084)2.02336929
124Abnormality of the gallbladder (HP:0005264)2.02022294
125Irritability (HP:0000737)1.99890693
126Sensorimotor neuropathy (HP:0007141)1.99768546
127Increased muscle lipid content (HP:0009058)1.99545460
128Proximal tubulopathy (HP:0000114)1.98883293
129Reduced subcutaneous adipose tissue (HP:0003758)1.98022786
130Lactic acidosis (HP:0003128)1.97359982
131Mitochondrial inheritance (HP:0001427)1.97142039
132Esophageal varix (HP:0002040)1.96682796
133Late onset (HP:0003584)1.96304715
134Pigmentary retinal degeneration (HP:0001146)1.95871496
135Bifid tongue (HP:0010297)1.95488479
136Hyperinsulinemic hypoglycemia (HP:0000825)1.94677545
137Protrusio acetabuli (HP:0003179)1.93973184
138Vertebral compression fractures (HP:0002953)1.92920296
139Glomerulonephritis (HP:0000099)1.92426875
140Bicornuate uterus (HP:0000813)1.92225144
141Increased CSF lactate (HP:0002490)1.91944421
142Facial hemangioma (HP:0000329)1.91631308
143Insulin resistance (HP:0000855)1.91277976
144Adrenal overactivity (HP:0002717)1.90769414
145Hepatic necrosis (HP:0002605)1.88734482
146Progressive macrocephaly (HP:0004481)1.86314697
147Abnormal mitochondria in muscle tissue (HP:0008316)1.85901201
148Elevated hepatic transaminases (HP:0002910)1.85599032
149Vascular calcification (HP:0004934)1.85385232
150Impulsivity (HP:0100710)1.85160697
151Enlarged kidneys (HP:0000105)1.83831408
152Mitral stenosis (HP:0001718)1.80738091
153Hypokalemic alkalosis (HP:0001949)1.80687014
154Metaphyseal dysplasia (HP:0100255)1.80332037
155Infantile muscular hypotonia (HP:0008947)1.79836636
156Gout (HP:0001997)1.77629598
157Recurrent gram-negative bacterial infections (HP:0005420)1.77025138
158Malnutrition (HP:0004395)1.76401281
159Poikilocytosis (HP:0004447)1.76317677
160Thrombophlebitis (HP:0004418)1.75517030
161Opisthotonus (HP:0002179)1.75057479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.86619445
2SIK14.65657127
3ERN14.18142983
4TRIB34.05201095
5CAMK1D3.49212909
6FGFR43.19699860
7EIF2AK32.57547714
8INSRR2.45551473
9CAMK12.43876568
10TSSK62.42784882
11MST1R2.31619556
12CAMK1G2.27868501
13PKN22.15117496
14GRK51.98687504
15PDK31.93979651
16PDK41.93979651
17LATS11.88351816
18NLK1.82691734
19ERBB41.78622198
20PRKAA21.73829324
21TAOK31.68337295
22NEK91.66547432
23MAPK111.59422527
24GRK11.48487732
25MAP2K41.47273094
26RIPK11.47039045
27FLT31.45340440
28FRK1.34256683
29TESK11.32287121
30FGFR21.31420514
31PIK3CG1.30986075
32ABL21.28547612
33DAPK31.27689825
34STK161.25834151
35DDR21.20069562
36BMPR1B1.17660944
37PDK21.16672943
38TYK21.11293141
39JAK21.08083195
40DAPK21.06427773
41PINK11.04368050
42EIF2AK11.02967245
43TIE11.02877925
44CDK61.00581858
45EPHB20.99937638
46JAK10.99429866
47NEK10.98882174
48MAP2K10.98696128
49STK38L0.98083607
50ILK0.96413169
51ADRBK10.94596782
52PRKAA10.94125348
53MET0.91429885
54PTK60.90162678
55FGFR30.90153984
56KDR0.89008360
57MAP3K30.88539966
58PIK3CA0.88143140
59MAP2K30.87995969
60TGFBR20.87295216
61NUAK10.86783635
62MAP3K60.85617485
63KIT0.85316888
64VRK20.82533818
65WNK30.81539298
66ZAK0.81095596
67PRKACG0.80580042
68CDK90.80257856
69PAK20.78196799
70MAPK120.75820039
71IRAK30.75814836
72MKNK10.75189964
73PDPK10.75165696
74TNIK0.75138067
75EIF2AK20.74974225
76CSNK1G10.71941563
77LATS20.71727904
78GSK3A0.70430053
79PBK0.70392557
80AKT20.68915493
81LMTK20.68415106
82MYLK0.67945916
83PRKG10.67214083
84TBK10.66967337
85TAF10.66925412
86PDGFRA0.65297952
87DYRK30.64962768
88PIM20.64635548
89MKNK20.64342944
90MAP3K70.63812559
91ACVR1B0.62808273
92CDK30.62708612
93MAPKAPK50.62565868
94CDK40.61860311
95MTOR0.60416138
96MAPK40.59062061
97PRKCZ0.57703202
98IGF1R0.57557198
99MAP3K130.56928764
100STK30.55090890
101YES10.53670623
102SCYL20.52392849
103DAPK10.51165181
104CLK10.50888720
105PDK10.50046097
106TEC0.49701997
107MAP3K110.48591790
108PRKCH0.46184659
109SRPK10.46057352
110MAP4K20.46013009
111AKT30.45501855
112MARK30.45199062
113KSR20.45125983
114RET0.45016260
115PLK30.44834146
116OBSCN0.44810288
117TGFBR10.42148659
118PRKACB0.41439897
119EPHA30.39484890
120RPS6KA30.38738420
121ERBB20.38727450
122RPS6KA50.38317860
123SGK30.37782049
124PRKD10.37256292
125CAMK2G0.37060811
126CSNK2A10.35811111
127MAP3K40.35574887
128PLK40.35164841
129EPHB10.34043288
130DYRK1B0.33191989
131MAP3K100.30368930
132MAP3K50.30263840
133BMX0.29159441
134FER0.28480654
135FGFR10.27304193
136ICK0.26119568
137CSF1R0.25797332
138CSK0.25589220
139MAPK30.23934883
140IRAK10.23442706
141MAPK70.22391311
142JAK30.22315379
143GRK60.22158579
144PTK20.20848239
145ABL10.20173818
146INSR0.20161616
147NME20.19874186
148PTK2B0.19463582
149IKBKE0.18907491
150IRAK20.18144881
151PRKACA0.17164016

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.82843664
2Nitrogen metabolism_Homo sapiens_hsa009103.17945092
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.97241098
4Fatty acid degradation_Homo sapiens_hsa000712.93084008
5Propanoate metabolism_Homo sapiens_hsa006402.92040052
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.78745391
7PPAR signaling pathway_Homo sapiens_hsa033202.75014524
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.74146854
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.63676713
10Arginine biosynthesis_Homo sapiens_hsa002202.59620873
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59431018
12Fatty acid metabolism_Homo sapiens_hsa012122.53213629
13Tryptophan metabolism_Homo sapiens_hsa003802.45327174
14Complement and coagulation cascades_Homo sapiens_hsa046102.36356691
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.25429459
16Peroxisome_Homo sapiens_hsa041462.19993244
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.18508002
18Butanoate metabolism_Homo sapiens_hsa006502.11904722
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.91609330
20beta-Alanine metabolism_Homo sapiens_hsa004101.88848856
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88227352
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88059688
23Pyruvate metabolism_Homo sapiens_hsa006201.86145948
24Caffeine metabolism_Homo sapiens_hsa002321.78022156
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71310244
26Chemical carcinogenesis_Homo sapiens_hsa052041.70148683
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70091450
28Fatty acid biosynthesis_Homo sapiens_hsa000611.69218983
29Staphylococcus aureus infection_Homo sapiens_hsa051501.61882813
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60448108
31Carbon metabolism_Homo sapiens_hsa012001.59448375
32Tyrosine metabolism_Homo sapiens_hsa003501.54467571
33Phenylalanine metabolism_Homo sapiens_hsa003601.54353855
34Fatty acid elongation_Homo sapiens_hsa000621.51841137
35Histidine metabolism_Homo sapiens_hsa003401.45975327
36Fat digestion and absorption_Homo sapiens_hsa049751.44905294
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42252527
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.40797406
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40654094
40Retinol metabolism_Homo sapiens_hsa008301.40606122
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37967224
42Biosynthesis of amino acids_Homo sapiens_hsa012301.24184262
43Glycerolipid metabolism_Homo sapiens_hsa005611.24095245
44Sulfur metabolism_Homo sapiens_hsa009201.23374412
45Vitamin B6 metabolism_Homo sapiens_hsa007501.23123003
46Selenocompound metabolism_Homo sapiens_hsa004501.22875808
47Bile secretion_Homo sapiens_hsa049761.20073127
48Starch and sucrose metabolism_Homo sapiens_hsa005001.18518147
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.14197457
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04235346
51ABC transporters_Homo sapiens_hsa020101.00813717
52Folate biosynthesis_Homo sapiens_hsa007900.99904692
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95484665
54Sulfur relay system_Homo sapiens_hsa041220.91936447
55Steroid biosynthesis_Homo sapiens_hsa001000.90571010
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84115665
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82261102
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80511473
59Proteasome_Homo sapiens_hsa030500.80404566
60Pentose phosphate pathway_Homo sapiens_hsa000300.79262901
61Lysine degradation_Homo sapiens_hsa003100.78185689
62Glutathione metabolism_Homo sapiens_hsa004800.76489537
63Vitamin digestion and absorption_Homo sapiens_hsa049770.72263269
64RNA polymerase_Homo sapiens_hsa030200.69932387
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.68432480
66Arginine and proline metabolism_Homo sapiens_hsa003300.67319320
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60761641
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60344089
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.57571209
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.55814752
71Ribosome_Homo sapiens_hsa030100.55660804
72Renin-angiotensin system_Homo sapiens_hsa046140.49613746
73Metabolic pathways_Homo sapiens_hsa011000.48692785
74AMPK signaling pathway_Homo sapiens_hsa041520.47947356
75Insulin resistance_Homo sapiens_hsa049310.47100755
76Huntingtons disease_Homo sapiens_hsa050160.46545063
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42612023
78Fructose and mannose metabolism_Homo sapiens_hsa000510.37072263
79One carbon pool by folate_Homo sapiens_hsa006700.35338930
80ECM-receptor interaction_Homo sapiens_hsa045120.35122181
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34591947
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.32731109
83Glucagon signaling pathway_Homo sapiens_hsa049220.30421720
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29484629
85Ovarian steroidogenesis_Homo sapiens_hsa049130.29399255
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.29197530
87Linoleic acid metabolism_Homo sapiens_hsa005910.26795377
88Prion diseases_Homo sapiens_hsa050200.25893815
89Galactose metabolism_Homo sapiens_hsa000520.23762483
90Renin secretion_Homo sapiens_hsa049240.20718051
91Insulin signaling pathway_Homo sapiens_hsa049100.18710074
92Protein export_Homo sapiens_hsa030600.17756112
93Purine metabolism_Homo sapiens_hsa002300.14810364
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11043116
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.03839953
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.02600708
97Basal transcription factors_Homo sapiens_hsa030220.01901688
98Ether lipid metabolism_Homo sapiens_hsa005650.01173343
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2245761
100Regulation of autophagy_Homo sapiens_hsa04140-0.2237560
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.2119448
102Amoebiasis_Homo sapiens_hsa05146-0.2063273
103Protein digestion and absorption_Homo sapiens_hsa04974-0.2000133
104Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1971382
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1893365
106Alzheimers disease_Homo sapiens_hsa05010-0.1654493
107Hepatitis C_Homo sapiens_hsa05160-0.1599905
108Oxidative phosphorylation_Homo sapiens_hsa00190-0.1527610
109Type II diabetes mellitus_Homo sapiens_hsa04930-0.1516361
110Parkinsons disease_Homo sapiens_hsa05012-0.1333197
111Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.1086818
112Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0846572
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0719753
114Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0606826
115Base excision repair_Homo sapiens_hsa03410-0.0586513
116N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0524962
117Mineral absorption_Homo sapiens_hsa04978-0.0457600
118Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0342708
119Pyrimidine metabolism_Homo sapiens_hsa00240-0.0299893
120Malaria_Homo sapiens_hsa05144-0.0092551

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