MRAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.13143261
2auditory receptor cell stereocilium organization (GO:0060088)4.90966222
3glutamate secretion (GO:0014047)4.50270444
4vocalization behavior (GO:0071625)4.40370929
5detection of molecule of bacterial origin (GO:0032490)4.37194945
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.19546646
7neuron cell-cell adhesion (GO:0007158)3.93874364
8regulation of glutamate receptor signaling pathway (GO:1900449)3.92589403
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.92005447
10inner ear receptor stereocilium organization (GO:0060122)3.87674582
11membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.86514778
12detection of calcium ion (GO:0005513)3.82749511
13cellular potassium ion homeostasis (GO:0030007)3.80289257
14opioid receptor signaling pathway (GO:0038003)3.77198308
15negative regulation of synaptic transmission, GABAergic (GO:0032229)3.73646543
16regulation of synaptic vesicle exocytosis (GO:2000300)3.72496719
17regulation of type B pancreatic cell apoptotic process (GO:2000674)3.63749785
18potassium ion homeostasis (GO:0055075)3.62030742
19serotonin receptor signaling pathway (GO:0007210)3.55510109
20drinking behavior (GO:0042756)3.53937611
21synaptic vesicle docking involved in exocytosis (GO:0016081)3.50525441
22positive regulation of uterine smooth muscle contraction (GO:0070474)3.48447100
23chemosensory behavior (GO:0007635)3.47234085
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.44837908
25response to pheromone (GO:0019236)3.44305679
26startle response (GO:0001964)3.43479591
27negative regulation of macroautophagy (GO:0016242)3.43421163
28insulin secretion (GO:0030073)3.42307019
29regulation of short-term neuronal synaptic plasticity (GO:0048172)3.41238110
30positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.34442820
31positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.34270129
32membrane repolarization during action potential (GO:0086011)3.34021444
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.31491350
34potassium ion import (GO:0010107)3.31390387
35cellular anion homeostasis (GO:0030002)3.30649576
36neuron remodeling (GO:0016322)3.29302547
37positive regulation of synaptic transmission, GABAergic (GO:0032230)3.25969269
38negative regulation of hormone biosynthetic process (GO:0032353)3.23684705
39regulation of synaptic vesicle transport (GO:1902803)3.21179551
40presynaptic membrane assembly (GO:0097105)3.20303066
41negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.17763444
42post-embryonic morphogenesis (GO:0009886)3.16856554
43innervation (GO:0060384)3.15776851
44postsynaptic membrane organization (GO:0001941)3.15156500
45glutamate receptor signaling pathway (GO:0007215)3.14485112
46proline transport (GO:0015824)3.11541374
47positive regulation of neurotransmitter secretion (GO:0001956)3.11207825
48signal peptide processing (GO:0006465)3.11106813
49behavioral response to nicotine (GO:0035095)3.08117492
50protein localization to synapse (GO:0035418)3.07343013
51synaptic vesicle exocytosis (GO:0016079)3.06300083
52sodium ion export (GO:0071436)3.03867428
53regulation of calcium ion-dependent exocytosis (GO:0017158)3.03864094
54regulation of uterine smooth muscle contraction (GO:0070472)3.01828843
55negative regulation of neurotransmitter transport (GO:0051589)3.01164082
56synaptic transmission, glutamatergic (GO:0035249)3.00150219
57membrane repolarization (GO:0086009)2.98914554
58positive regulation of neurotransmitter transport (GO:0051590)2.98618061
59regulation of neuronal synaptic plasticity (GO:0048168)2.98435509
60positive regulation of neurological system process (GO:0031646)2.98397486
61neuron-neuron synaptic transmission (GO:0007270)2.98096893
62macroautophagy (GO:0016236)2.97231215
63regulation of glutamate secretion (GO:0014048)2.97124688
64righting reflex (GO:0060013)2.96604674
65synaptic vesicle maturation (GO:0016188)2.95885415
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95423395
67aggressive behavior (GO:0002118)2.92457605
68negative regulation of amino acid transport (GO:0051956)2.91956291
69sulfate transmembrane transport (GO:1902358)2.91298182
70erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.90763163
71L-phenylalanine catabolic process (GO:0006559)2.90763163
72negative regulation of hormone metabolic process (GO:0032351)2.90596271
73regulation of vesicle fusion (GO:0031338)2.89335403
74nitric oxide mediated signal transduction (GO:0007263)2.89121179
75regulation of neurotransmitter levels (GO:0001505)2.88699948
76response to histamine (GO:0034776)2.87522103
77presynaptic membrane organization (GO:0097090)2.87448789
78behavioral response to ethanol (GO:0048149)2.84987523
79regulation of heart rate by cardiac conduction (GO:0086091)2.84527700
80positive regulation of synapse maturation (GO:0090129)2.83671878
81positive regulation of synapse assembly (GO:0051965)2.83394900
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.82221489
83L-phenylalanine metabolic process (GO:0006558)2.82221489
84endocrine pancreas development (GO:0031018)2.81328051
85negative regulation of cytosolic calcium ion concentration (GO:0051481)2.81143182
86detection of external biotic stimulus (GO:0098581)2.81018474
87positive regulation of cellular amide metabolic process (GO:0034250)2.81013009
88positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.78414606
89glycine transport (GO:0015816)2.78324340
90prostate gland growth (GO:0060736)2.77747565
91negative regulation of dendrite morphogenesis (GO:0050774)2.77497480
92regulation of insulin secretion (GO:0050796)2.77261840
93negative regulation of gluconeogenesis (GO:0045721)2.75079581
94positive regulation of macroautophagy (GO:0016239)2.74398341
95regulation of long-term neuronal synaptic plasticity (GO:0048169)2.73763904
96neurotransmitter secretion (GO:0007269)2.71712385
97locomotory exploration behavior (GO:0035641)2.71524068
98cardiac conduction (GO:0061337)2.71229652
99urinary tract smooth muscle contraction (GO:0014848)2.70268624
100neurotransmitter transport (GO:0006836)2.70019542
101transmission of nerve impulse (GO:0019226)2.69809364
102cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.69759491
103serotonin metabolic process (GO:0042428)2.69572723
104neurotransmitter-gated ion channel clustering (GO:0072578)2.69521580
105regulation of glucokinase activity (GO:0033131)2.69387362
106regulation of hexokinase activity (GO:1903299)2.69387362
107positive regulation of action potential (GO:0045760)2.69354385
108regulation of neurotransmitter secretion (GO:0046928)2.68949209
109dopamine biosynthetic process (GO:0042416)2.68858683
110signal release (GO:0023061)2.67992789
111regulation of synaptic transmission, GABAergic (GO:0032228)2.67314754
112cellular sodium ion homeostasis (GO:0006883)2.65022398
113cellular ketone body metabolic process (GO:0046950)2.62953670
114regulation of neurotransmitter transport (GO:0051588)2.62889090
115synapse assembly (GO:0007416)2.62728556
116regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62682107
117membrane depolarization during action potential (GO:0086010)2.62377968
118positive regulation of insulin secretion (GO:0032024)2.62243675
119negative regulation of response to nutrient levels (GO:0032108)2.61368624
120negative regulation of response to extracellular stimulus (GO:0032105)2.61368624
121pteridine-containing compound biosynthetic process (GO:0042559)2.60635875
122inositol phosphate catabolic process (GO:0071545)2.60626439
123phagosome maturation (GO:0090382)2.59407694
124glycoside metabolic process (GO:0016137)2.59143202
125neuron recognition (GO:0008038)2.59119561
126response to auditory stimulus (GO:0010996)2.58457395
127neuromuscular process controlling posture (GO:0050884)2.58080512
128regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.57406441
129positive regulation of meiosis (GO:0045836)2.56264223
130regulation of respiratory system process (GO:0044065)2.56197017
131cellular response to ammonium ion (GO:0071242)2.56006634
132cerebellar Purkinje cell layer development (GO:0021680)2.55800293
133catecholamine transport (GO:0051937)2.55229656
134adult feeding behavior (GO:0008343)2.54986634
135cerebellar Purkinje cell differentiation (GO:0021702)2.54655624
136regulation of Rac protein signal transduction (GO:0035020)2.54420623
137neuronal action potential propagation (GO:0019227)2.53376448
138peptide hormone secretion (GO:0030072)2.52474060
139cellular potassium ion transport (GO:0071804)2.52409427
140potassium ion transmembrane transport (GO:0071805)2.52409427
141axonemal dynein complex assembly (GO:0070286)2.51561969
142synaptic vesicle endocytosis (GO:0048488)2.50704532
143cerebral cortex radially oriented cell migration (GO:0021799)2.50112606
144membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.49898290
145regulation of synaptic transmission, glutamatergic (GO:0051966)2.49020768
146forebrain neuron differentiation (GO:0021879)2.48284525
147glycerophospholipid catabolic process (GO:0046475)2.47956646
148negative regulation of synaptic transmission (GO:0050805)2.47886598
149neuromuscular synaptic transmission (GO:0007274)2.47525474
150sulfate transport (GO:0008272)2.46179999
151regulation of peptide hormone secretion (GO:0090276)2.45971279
152regulation of synapse assembly (GO:0051963)2.45721714
153positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.45577410
154neurotransmitter uptake (GO:0001504)2.45563674
155positive regulation of amino acid transport (GO:0051957)2.44735988
156L-alpha-amino acid transmembrane transport (GO:1902475)2.44626813
157cerebellar granule cell differentiation (GO:0021707)2.43842064
158regulation of peptide secretion (GO:0002791)2.42185580
159peptide secretion (GO:0002790)2.41539648
160positive regulation of meiotic cell cycle (GO:0051446)2.38261519
161glandular epithelial cell differentiation (GO:0002067)2.37969258
162primary amino compound metabolic process (GO:1901160)2.37546826
163regulation of oxidative phosphorylation (GO:0002082)2.36935708
164regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.35666839
165dopamine transport (GO:0015872)2.35601234
166synaptic transmission (GO:0007268)2.34349799
167regulation of autophagic vacuole assembly (GO:2000785)2.33675082
168regulation of exocytosis (GO:0017157)2.33289832
169succinate metabolic process (GO:0006105)2.33260478
170potassium ion transport (GO:0006813)2.33104716
171dendritic spine morphogenesis (GO:0060997)2.31071322
172polyketide metabolic process (GO:0030638)11.1086367
173doxorubicin metabolic process (GO:0044598)11.1086367
174daunorubicin metabolic process (GO:0044597)11.1086367

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.07606785
2GBX2_23144817_ChIP-Seq_PC3_Human4.16027325
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.91783688
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75466499
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.72529429
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71041100
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65375027
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63037367
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46345012
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.46054466
11TAF15_26573619_Chip-Seq_HEK293_Human2.45684194
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.45384688
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35768693
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34517425
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33705304
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33705304
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27720876
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.24126382
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18208093
20* REST_21632747_ChIP-Seq_MESCs_Mouse2.15247848
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12046735
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95260179
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94337835
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93978549
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.93435700
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.93081396
27* P300_19829295_ChIP-Seq_ESCs_Human1.90068564
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.88646559
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.87832598
30IGF1R_20145208_ChIP-Seq_DFB_Human1.85494116
31DROSHA_22980978_ChIP-Seq_HELA_Human1.85090630
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82450981
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80991109
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78142988
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.77681165
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76098429
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75597007
38SMAD4_21799915_ChIP-Seq_A2780_Human1.72428226
39VDR_22108803_ChIP-Seq_LS180_Human1.70589493
40RNF2_27304074_Chip-Seq_NSC_Mouse1.67358339
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62777229
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62168629
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62021228
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59386655
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58696739
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57840751
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.57123127
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56364915
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.52051264
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49142229
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.48951880
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.48850781
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46006263
54* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45860453
55ER_23166858_ChIP-Seq_MCF-7_Human1.45317390
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44770325
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44592630
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.42900099
59HTT_18923047_ChIP-ChIP_STHdh_Human1.41998002
60AR_25329375_ChIP-Seq_VCAP_Human1.41037621
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40888315
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.40390976
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35919485
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35560055
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35367461
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.34151234
67AR_21572438_ChIP-Seq_LNCaP_Human1.34149566
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33923236
69FUS_26573619_Chip-Seq_HEK293_Human1.30341552
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.30210413
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30053816
72P53_22387025_ChIP-Seq_ESCs_Mouse1.30048966
73SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28817830
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27625282
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.26074146
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24628551
77STAT3_23295773_ChIP-Seq_U87_Human1.24418147
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23605919
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.23467997
80RUNX2_22187159_ChIP-Seq_PCA_Human1.21935887
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21509323
82TBL1_22424771_ChIP-Seq_293T_Human1.20482465
83JUN_21703547_ChIP-Seq_K562_Human1.20348237
84BCAT_22108803_ChIP-Seq_LS180_Human1.20223750
85TCF4_23295773_ChIP-Seq_U87_Human1.19310137
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.19194923
87PHF8_20622853_ChIP-Seq_HELA_Human1.18886250
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18660185
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16923131
90NMYC_18555785_Chip-Seq_ESCs_Mouse1.16074469
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.14054083
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14033304
93PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.13377844
94P300_18555785_Chip-Seq_ESCs_Mouse1.13205145
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12248626
96NFYB_21822215_ChIP-Seq_K562_Human1.11748420
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11331129
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11331129
99* TP53_22573176_ChIP-Seq_HFKS_Human1.09112200
100RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08835535
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07890855
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06967089
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06582720
104KDM2B_26808549_Chip-Seq_REH_Human1.06172528
105KLF4_18555785_Chip-Seq_ESCs_Mouse1.05185214
106RING1B_27294783_Chip-Seq_ESCs_Mouse1.05151210
107CTCF_18555785_Chip-Seq_ESCs_Mouse1.04743034
108* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04238362
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04218183
110RBPJ_21746931_ChIP-Seq_IB4_Human1.03349464
111CBX2_22325352_ChIP-Seq_293T-Rex_Human1.03259989
112* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03176621
113ETV1_20927104_ChIP-Seq_GIST48_Human1.02617943
114OCT4_18555785_Chip-Seq_ESCs_Mouse1.01767406
115NFYA_21822215_ChIP-Seq_K562_Human1.01742727
116TP53_18474530_ChIP-ChIP_U2OS_Human1.01638372
117SMAD3_21741376_ChIP-Seq_HESCs_Human1.01534064
118SMAD4_21741376_ChIP-Seq_HESCs_Human1.01471885
119ZNF274_21170338_ChIP-Seq_K562_Hela1.01431961
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01351233
121P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01000604
122PU1_27457419_Chip-Seq_LIVER_Mouse1.00854929
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00693759
124SOX2_21211035_ChIP-Seq_LN229_Gbm1.00308835
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99805297
126TCF4_22108803_ChIP-Seq_LS180_Human0.97516455
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95856544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol4.87453006
2MP0006276_abnormal_autonomic_nervous4.04522551
3MP0003880_abnormal_central_pattern3.85197266
4MP0009780_abnormal_chondrocyte_physiolo3.08208945
5MP0005423_abnormal_somatic_nervous3.03406286
6MP0001501_abnormal_sleep_pattern2.88714964
7MP0003878_abnormal_ear_physiology2.82990487
8MP0005377_hearing/vestibular/ear_phenot2.82990487
9MP0009046_muscle_twitch2.78340516
10MP0003122_maternal_imprinting2.77889254
11MP0005646_abnormal_pituitary_gland2.77729087
12MP0008004_abnormal_stomach_pH2.74878289
13MP0004859_abnormal_synaptic_plasticity2.66127227
14MP0003195_calcinosis2.65191099
15MP0009745_abnormal_behavioral_response2.64143570
16MP0003635_abnormal_synaptic_transmissio2.53270968
17MP0002572_abnormal_emotion/affect_behav2.48816549
18MP0001968_abnormal_touch/_nociception2.41274475
19MP0002064_seizures2.38376736
20MP0001486_abnormal_startle_reflex2.33537857
21MP0002272_abnormal_nervous_system2.29467237
22MP0002638_abnormal_pupillary_reflex2.28624802
23MP0008877_abnormal_DNA_methylation2.23395390
24MP0002735_abnormal_chemical_nociception2.22131221
25MP0003879_abnormal_hair_cell2.19430080
26MP0003123_paternal_imprinting2.18500484
27MP0001440_abnormal_grooming_behavior2.18332997
28MP0006072_abnormal_retinal_apoptosis2.11566496
29MP0006292_abnormal_olfactory_placode2.10627721
30MP0002063_abnormal_learning/memory/cond2.05285451
31MP0010386_abnormal_urinary_bladder2.04371541
32MP0004742_abnormal_vestibular_system1.97820146
33MP0009697_abnormal_copulation1.95742197
34MP0002557_abnormal_social/conspecific_i1.93434037
35MP0001529_abnormal_vocalization1.93166220
36MP0002736_abnormal_nociception_after1.89513367
37MP0003787_abnormal_imprinting1.85190312
38MP0004885_abnormal_endolymph1.83143667
39MP0002734_abnormal_mechanical_nocicepti1.83054292
40MP0001502_abnormal_circadian_rhythm1.82894997
41MP0001944_abnormal_pancreas_morphology1.76180396
42MP0003283_abnormal_digestive_organ1.74974311
43MP0001984_abnormal_olfaction1.72116778
44MP0004147_increased_porphyrin_level1.71990885
45MP0004142_abnormal_muscle_tone1.69739385
46MP0002837_dystrophic_cardiac_calcinosis1.69511757
47MP0002733_abnormal_thermal_nociception1.68005634
48MP0002067_abnormal_sensory_capabilities1.66658711
49MP0004924_abnormal_behavior1.66368570
50MP0005386_behavior/neurological_phenoty1.66368570
51MP0002184_abnormal_innervation1.65622198
52MP0004043_abnormal_pH_regulation1.65016249
53MP0002163_abnormal_gland_morphology1.64742381
54MP0001970_abnormal_pain_threshold1.64592725
55MP0001986_abnormal_taste_sensitivity1.57764721
56MP0001188_hyperpigmentation1.56187954
57MP0004019_abnormal_vitamin_homeostasis1.55126631
58MP0005220_abnormal_exocrine_pancreas1.43398001
59MP0002090_abnormal_vision1.38986335
60MP0005379_endocrine/exocrine_gland_phen1.37733668
61MP0002876_abnormal_thyroid_physiology1.35528799
62MP0004270_analgesia1.34092730
63MP0000013_abnormal_adipose_tissue1.33617982
64MP0001485_abnormal_pinna_reflex1.33536094
65MP0004133_heterotaxia1.33496002
66MP0002693_abnormal_pancreas_physiology1.32725590
67MP0001905_abnormal_dopamine_level1.32477153
68MP0005171_absent_coat_pigmentation1.32193181
69MP0002139_abnormal_hepatobiliary_system1.31652724
70MP0010234_abnormal_vibrissa_follicle1.30408993
71MP0002277_abnormal_respiratory_mucosa1.23013078
72MP0000678_abnormal_parathyroid_gland1.22520353
73MP0005636_abnormal_mineral_homeostasis1.20384385
74MP0005332_abnormal_amino_acid1.17318237
75MP0002078_abnormal_glucose_homeostasis1.13435443
76MP0002822_catalepsy1.11401407
77MP0000566_synostosis1.09456358
78MP0000631_abnormal_neuroendocrine_gland1.09192813
79MP0000778_abnormal_nervous_system1.07507251
80MP0000639_abnormal_adrenal_gland1.03650974
81MP0004215_abnormal_myocardial_fiber1.03556803
82MP0001963_abnormal_hearing_physiology1.03201282
83MP0006036_abnormal_mitochondrial_physio1.01757916
84MP0010329_abnormal_lipoprotein_level1.01479755
85MP0003646_muscle_fatigue1.01123791
86MP0001765_abnormal_ion_homeostasis1.00980174
87MP0005253_abnormal_eye_physiology1.00137122
88MP0002066_abnormal_motor_capabilities/c0.99886494
89MP0001756_abnormal_urination0.99283214
90MP0005551_abnormal_eye_electrophysiolog0.98753286
91MP0002102_abnormal_ear_morphology0.97652811
92MP0003121_genomic_imprinting0.94560750
93MP0003329_amyloid_beta_deposits0.91257020
94MP0004858_abnormal_nervous_system0.90221263
95MP0002882_abnormal_neuron_morphology0.89757265
96MP0000026_abnormal_inner_ear0.89041521
97MP0001664_abnormal_digestion0.86567077
98MP0003868_abnormal_feces_composition0.86225221
99MP0005310_abnormal_salivary_gland0.85433179
100MP0003953_abnormal_hormone_level0.85420616
101MP0000462_abnormal_digestive_system0.84887238
102MP0005365_abnormal_bile_salt0.83511199
103MP0003183_abnormal_peptide_metabolism0.82388456
104MP0000681_abnormal_thyroid_gland0.81814867
105MP0000538_abnormal_urinary_bladder0.81502199
106MP0004811_abnormal_neuron_physiology0.78305395
107MP0005448_abnormal_energy_balance0.78190838
108MP0005409_darkened_coat_color0.78134942
109MP0003632_abnormal_nervous_system0.76539477
110MP0008569_lethality_at_weaning0.75382137
111MP0000955_abnormal_spinal_cord0.74711218
112MP0005535_abnormal_body_temperature0.73431241
113MP0003136_yellow_coat_color0.72874471
114MP0004782_abnormal_surfactant_physiolog0.72873949
115MP0003634_abnormal_glial_cell0.72630646
116MP0002069_abnormal_eating/drinking_beha0.72432265
117MP0008057_abnormal_DNA_replication0.71302768
118MP0008872_abnormal_physiological_respon0.70200995
119MP0004085_abnormal_heartbeat0.69896136
120MP0002752_abnormal_somatic_nervous0.69383423
121MP0008874_decreased_physiological_sensi0.69223474
122MP0002229_neurodegeneration0.68712820
123MP0003633_abnormal_nervous_system0.68479964
124MP0002132_abnormal_respiratory_system0.63375370
125MP0005499_abnormal_olfactory_system0.60900792
126MP0005394_taste/olfaction_phenotype0.60900792
127MP0001346_abnormal_lacrimal_gland0.58678287
128MP0001177_atelectasis0.57111645
129MP0003690_abnormal_glial_cell0.56520376
130MP0003631_nervous_system_phenotype0.56211499
131MP0000015_abnormal_ear_pigmentation0.54302927
132MP0000569_abnormal_digit_pigmentation0.54023529
133MP0002152_abnormal_brain_morphology0.51954534
134MP0000372_irregular_coat_pigmentation0.51121398
135MP0002751_abnormal_autonomic_nervous0.50984631
136MP0002148_abnormal_hypersensitivity_rea0.50235436
137MP0002938_white_spotting0.49534199
138MP0002909_abnormal_adrenal_gland0.48468080

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.79905045
2Hyperinsulinemic hypoglycemia (HP:0000825)5.62369768
3Focal motor seizures (HP:0011153)5.28058425
4Hypoglycemic seizures (HP:0002173)5.23674506
5Dynein arm defect of respiratory motile cilia (HP:0012255)4.78355495
6Absent/shortened dynein arms (HP:0200106)4.78355495
7Unilateral renal agenesis (HP:0000122)4.63741090
8Febrile seizures (HP:0002373)4.39899262
9Hypoglycemic coma (HP:0001325)4.25020032
10Abnormality of dental color (HP:0011073)4.22124919
11Abnormal ciliary motility (HP:0012262)4.08760416
12Hyperglycemia (HP:0003074)4.04043879
13Follicular hyperkeratosis (HP:0007502)4.02706233
14Alopecia of scalp (HP:0002293)4.01545832
15Abnormality of aromatic amino acid family metabolism (HP:0004338)3.96870847
16Epileptiform EEG discharges (HP:0011182)3.87975455
17Ketoacidosis (HP:0001993)3.79680456
18EEG with generalized epileptiform discharges (HP:0011198)3.77459687
19Abnormal respiratory epithelium morphology (HP:0012253)3.75684978
20Abnormal respiratory motile cilium morphology (HP:0005938)3.75684978
21Hypsarrhythmia (HP:0002521)3.61595653
22Absent eyebrow (HP:0002223)3.60871313
23Abnormal hair whorl (HP:0010721)3.60417726
24Recurrent corneal erosions (HP:0000495)3.59813333
25Symptomatic seizures (HP:0011145)3.57974020
26Bilateral sensorineural hearing impairment (HP:0008619)3.54759552
27Hypothermia (HP:0002045)3.49152659
28Abnormality of the pancreatic islet cells (HP:0006476)3.44995950
29Abnormality of endocrine pancreas physiology (HP:0012093)3.44995950
30Hyperphosphatemia (HP:0002905)3.43414996
31Increased circulating renin level (HP:0000848)3.40421779
32Focal seizures (HP:0007359)3.36851676
33Cheilitis (HP:0100825)3.34991575
34Congenital malformation of the right heart (HP:0011723)3.33200067
35Double outlet right ventricle (HP:0001719)3.33200067
36Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.31734867
37Epileptic encephalopathy (HP:0200134)3.28906252
38Atonic seizures (HP:0010819)3.25271771
39Pancreatic islet-cell hyperplasia (HP:0004510)3.25001672
40Abnormal respiratory motile cilium physiology (HP:0012261)3.21156994
41Progressive cerebellar ataxia (HP:0002073)3.12203161
42Large for gestational age (HP:0001520)3.10131635
43Insulin-resistant diabetes mellitus (HP:0000831)3.02306041
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.97332162
45Absent eyelashes (HP:0000561)2.90388645
46Abnormality of calcium-phosphate metabolism (HP:0100530)2.81232172
47Rhinitis (HP:0012384)2.71713039
48Fetal akinesia sequence (HP:0001989)2.69141406
49Myokymia (HP:0002411)2.64968660
50Abolished electroretinogram (ERG) (HP:0000550)2.64135535
51Polyphagia (HP:0002591)2.62483781
52Late onset (HP:0003584)2.62029122
53Generalized tonic-clonic seizures (HP:0002069)2.60893642
54Absence seizures (HP:0002121)2.60302152
55Abnormality of the labia minora (HP:0012880)2.58257619
56Hypomagnesemia (HP:0002917)2.54816298
57Hyperventilation (HP:0002883)2.54617452
58Truncus arteriosus (HP:0001660)2.52906559
59Chronic sinusitis (HP:0011109)2.51814773
60Septo-optic dysplasia (HP:0100842)2.51708453
61Hyperthyroidism (HP:0000836)2.51277188
62Dialeptic seizures (HP:0011146)2.42648750
63Renal dysplasia (HP:0000110)2.42063320
64Tetany (HP:0001281)2.40355614
65Muscular hypotonia of the trunk (HP:0008936)2.38114113
66Failure to thrive in infancy (HP:0001531)2.37575301
67Anxiety (HP:0000739)2.34248591
68Chronic bronchitis (HP:0004469)2.32156793
69Intestinal atresia (HP:0011100)2.30303315
70Abnormality of renin-angiotensin system (HP:0000847)2.28545817
71Abnormality of incisor morphology (HP:0011063)2.28535600
72Action tremor (HP:0002345)2.27895538
73Congenital sensorineural hearing impairment (HP:0008527)2.27761906
74Chronic hepatic failure (HP:0100626)2.27516995
75Medial flaring of the eyebrow (HP:0010747)2.26576534
76Prominent metopic ridge (HP:0005487)2.24097173
77Osteomalacia (HP:0002749)2.22953852
78Nephrogenic diabetes insipidus (HP:0009806)2.20537175
79Torticollis (HP:0000473)2.14831253
80Limb dystonia (HP:0002451)2.12399894
81Abnormality of magnesium homeostasis (HP:0004921)2.11154805
82Status epilepticus (HP:0002133)2.09463517
83Ventricular fibrillation (HP:0001663)2.09299971
84Gait imbalance (HP:0002141)2.08810633
85Abnormality of the metopic suture (HP:0005556)2.08737915
86Narrow nasal bridge (HP:0000446)2.06403554
87Decreased central vision (HP:0007663)2.04697923
88Abnormal eating behavior (HP:0100738)2.03900738
89Broad-based gait (HP:0002136)2.03624529
90Focal dystonia (HP:0004373)2.03612406
91Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03453919
92True hermaphroditism (HP:0010459)2.03229465
93Hemiparesis (HP:0001269)2.02547866
94Ketosis (HP:0001946)2.01864630
95Erythroderma (HP:0001019)2.00514683
96Chronic otitis media (HP:0000389)2.00176975
97Congenital primary aphakia (HP:0007707)1.97417850
98Poor suck (HP:0002033)1.97057885
99Pancreatic fibrosis (HP:0100732)1.96922181
100Choreoathetosis (HP:0001266)1.96799826
101Abnormal sex determination (HP:0012244)1.96771437
102Sex reversal (HP:0012245)1.96771437
103Drooling (HP:0002307)1.96073434
104Visual hallucinations (HP:0002367)1.95269136
105Abnormality of midbrain morphology (HP:0002418)1.93986650
106Molar tooth sign on MRI (HP:0002419)1.93986650
107Prolonged partial thromboplastin time (HP:0003645)1.92703208
108Craniofacial dystonia (HP:0012179)1.91599639
109Agitation (HP:0000713)1.91130806
110Absent speech (HP:0001344)1.90410712
111Retrobulbar optic neuritis (HP:0100654)1.89214877
112Optic neuritis (HP:0100653)1.89214877
113Diminished movement (HP:0002374)1.88614263
114Syncope (HP:0001279)1.87599666
115Neuroendocrine neoplasm (HP:0100634)1.86185964
116Hip dysplasia (HP:0001385)1.85125572
117Blue irides (HP:0000635)1.83451177
118Patchy hypopigmentation of hair (HP:0011365)1.83170035
119Cerebral hypomyelination (HP:0006808)1.81604013
120Absent hair (HP:0002298)1.81316992
121Aplasia of the musculature (HP:0100854)1.79788932
122Hypocalcemia (HP:0002901)1.78886191
123Keratitis (HP:0000491)1.78573644
124Gaze-evoked nystagmus (HP:0000640)1.78283640
125Amelogenesis imperfecta (HP:0000705)1.77127443
126White forelock (HP:0002211)1.76379760
127Nephronophthisis (HP:0000090)1.75671914
128Abnormality of the renal collecting system (HP:0004742)1.74416198
129Ectropion (HP:0000656)1.73594868
130Decreased circulating renin level (HP:0003351)1.72818149
131Esotropia (HP:0000565)1.72539709
132Amblyopia (HP:0000646)1.72158057
133Excessive salivation (HP:0003781)1.70651459
134Sleep apnea (HP:0010535)1.70145924
135Corneal dystrophy (HP:0001131)1.69894326
136Hyperactive renin-angiotensin system (HP:0000841)1.68710494
137Progressive macrocephaly (HP:0004481)1.68617837
138Progressive inability to walk (HP:0002505)1.68437473
139Abnormality of binocular vision (HP:0011514)1.67752742
140Diplopia (HP:0000651)1.67752742
141Intention tremor (HP:0002080)1.67358659
142Absent septum pellucidum (HP:0001331)1.67078974
143Duplicated collecting system (HP:0000081)1.66852850
144Testicular neoplasm (HP:0010788)1.66403847
145Aplasia/Hypoplasia of the lens (HP:0008063)1.65901830
146Widely spaced teeth (HP:0000687)1.64904185
147Arthropathy (HP:0003040)1.64182302
148Prostate neoplasm (HP:0100787)1.63935914
149Impaired vibration sensation in the lower limbs (HP:0002166)1.63857514
150Optic nerve hypoplasia (HP:0000609)1.63595893
151Acute encephalopathy (HP:0006846)1.63481065
152Acute necrotizing encephalopathy (HP:0006965)1.63470618
153Akinesia (HP:0002304)1.63438349
154Abnormal drinking behavior (HP:0030082)1.61631813
155Polydipsia (HP:0001959)1.61631813
156Metabolic alkalosis (HP:0200114)1.61596307
157Bradycardia (HP:0001662)1.61065405
158Bile duct proliferation (HP:0001408)1.60901644
159Abnormal biliary tract physiology (HP:0012439)1.60901644
160Menstrual irregularities (HP:0000858)1.59949764
161Pheochromocytoma (HP:0002666)1.57771375
162Abnormality of renal resorption (HP:0011038)1.57176403

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.85668675
2MAP3K123.85086693
3CASK3.56886143
4NTRK33.54522754
5SIK23.31538648
6MAP2K72.77005958
7FRK2.60148044
8GRK72.50969966
9PRPF4B2.42351992
10TNIK2.37057339
11ADRBK22.27873513
12MAP3K42.04347373
13MAPK131.85095765
14WNK41.83291765
15CAMK1G1.79575221
16MST41.77443000
17SIK11.73448829
18EPHA41.71140609
19TRPM71.66322233
20MAP2K41.62813936
21NTRK21.61674425
22FGFR21.47794562
23MAP3K21.44261983
24TXK1.43458520
25MARK11.40302796
26MAP4K21.35713604
27MARK31.34790364
28TNK21.34095170
29MINK11.29676928
30RIPK41.27684287
31BMPR21.22859200
32INSRR1.22203547
33SGK21.11472898
34AKT31.10095478
35NLK1.08254091
36MAP3K141.08227720
37CAMK2A1.05902111
38MAP3K131.05466267
39PRKD31.04190600
40MAP2K61.03764600
41EPHA20.99940079
42YES10.99815632
43GRK50.98332491
44TRIM280.97524823
45NME10.95599976
46WNK10.94551561
47CAMK1D0.91496501
48SGK4940.91457296
49SGK2230.91457296
50IRAK40.91239291
51STK390.90553642
52PRKCG0.90405545
53PNCK0.90262849
54BMPR1B0.89241435
55IRAK20.88765413
56CAMK10.88119074
57LIMK10.87133781
58OXSR10.86707986
59FES0.84785014
60PLK20.84000026
61UHMK10.83785794
62PLK30.82274706
63BLK0.79859425
64PRKCE0.77281658
65MAPK150.77012282
66ZAK0.76060969
67MUSK0.75681569
68TSSK60.75580201
69PRKG20.74742453
70STK380.74638011
71MAP3K90.73454504
72BCR0.73162704
73CDK190.72456616
74STK38L0.71791668
75ALK0.70156449
76NEK60.69210333
77CDK30.68119138
78CDK50.67628527
79PASK0.67406195
80IRAK10.64633154
81DAPK20.64411621
82CSNK1G20.63443651
83MARK20.62947839
84ADRBK10.62673935
85PKN10.61829192
86MAP3K10.61720787
87SGK10.61600291
88WNK30.60236405
89PRKG10.58770703
90CAMKK20.58585812
91NTRK10.58417877
92TTK0.57404805
93CAMK2G0.57346177
94KSR20.56892093
95CSNK1G30.56162888
96PINK10.55721352
97STK30.54829092
98CSNK1E0.54697016
99FGFR30.54255049
100PTK2B0.53262704
101MAPKAPK50.52255815
102IRAK30.52240463
103CAMK2B0.52030175
104HIPK20.50979333
105CAMK2D0.50670633
106SGK30.49778536
107LATS20.49646475
108MKNK20.49583338
109DYRK1A0.49438327
110PRKAA10.46962558
111PAK30.46682399
112DAPK10.45859315
113STK110.45713363
114CDK80.44892617
115ERBB30.44609780
116RPS6KA30.44053012
117SCYL20.43763414
118PAK60.43527809
119OBSCN0.42923263
120PTK20.42417147
121NUAK10.40430041
122PRKACA0.40343941
123RAF10.39837059
124CSNK1A1L0.39677718
125CAMK40.39529483
126CDK140.38394395
127GRK10.36086571
128PRKCQ0.35466425
129STK160.35207029
130ARAF0.34545561
131EIF2AK20.32929443
132PRKCA0.32087802
133BRAF0.31364977
134CSNK1G10.30040345
135FER0.29448668
136CSNK1A10.28726381
137TAOK20.28041546
138PHKG20.26337640
139PHKG10.26337640

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.69826253
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.22240167
3Synaptic vesicle cycle_Homo sapiens_hsa047213.40237132
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71873393
5GABAergic synapse_Homo sapiens_hsa047272.71307308
6Morphine addiction_Homo sapiens_hsa050322.70893089
7Serotonergic synapse_Homo sapiens_hsa047262.68488265
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.61934576
9Collecting duct acid secretion_Homo sapiens_hsa049662.53255164
10Taste transduction_Homo sapiens_hsa047422.50568804
11Vitamin B6 metabolism_Homo sapiens_hsa007502.29694415
12Olfactory transduction_Homo sapiens_hsa047402.17653809
13Circadian entrainment_Homo sapiens_hsa047132.15824329
14Glutamatergic synapse_Homo sapiens_hsa047242.05591442
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.05294680
16Folate biosynthesis_Homo sapiens_hsa007902.01387831
17Butanoate metabolism_Homo sapiens_hsa006501.97490422
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.76217701
19Amphetamine addiction_Homo sapiens_hsa050311.75800704
20Calcium signaling pathway_Homo sapiens_hsa040201.73426316
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.72057672
22Oxidative phosphorylation_Homo sapiens_hsa001901.68875650
23Cocaine addiction_Homo sapiens_hsa050301.67154974
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66229308
25Insulin secretion_Homo sapiens_hsa049111.65699254
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.56876802
27Salivary secretion_Homo sapiens_hsa049701.56567740
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.55702294
29Rheumatoid arthritis_Homo sapiens_hsa053231.55058559
30Dopaminergic synapse_Homo sapiens_hsa047281.49312972
31Vibrio cholerae infection_Homo sapiens_hsa051101.48182676
32Type I diabetes mellitus_Homo sapiens_hsa049401.43907988
33Cholinergic synapse_Homo sapiens_hsa047251.43181859
34Long-term depression_Homo sapiens_hsa047301.39547514
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38235864
36Renin secretion_Homo sapiens_hsa049241.31409841
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24053265
38Long-term potentiation_Homo sapiens_hsa047201.20561580
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17185746
40Axon guidance_Homo sapiens_hsa043601.16772842
41Mineral absorption_Homo sapiens_hsa049781.08287761
42Phagosome_Homo sapiens_hsa041451.05474931
43Gastric acid secretion_Homo sapiens_hsa049711.05073901
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02839781
45Alzheimers disease_Homo sapiens_hsa050101.02490667
46Selenocompound metabolism_Homo sapiens_hsa004501.01556611
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98781471
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97937061
49Arginine biosynthesis_Homo sapiens_hsa002200.96372279
50Phototransduction_Homo sapiens_hsa047440.96294240
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94762316
52Parkinsons disease_Homo sapiens_hsa050120.94700460
53Fatty acid elongation_Homo sapiens_hsa000620.93855210
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93852110
55Oxytocin signaling pathway_Homo sapiens_hsa049210.93759294
56Cardiac muscle contraction_Homo sapiens_hsa042600.93521527
57Type II diabetes mellitus_Homo sapiens_hsa049300.93197637
58Autoimmune thyroid disease_Homo sapiens_hsa053200.93105593
59beta-Alanine metabolism_Homo sapiens_hsa004100.92635808
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92015263
61cAMP signaling pathway_Homo sapiens_hsa040240.91589089
62Sulfur metabolism_Homo sapiens_hsa009200.90601652
63Ovarian steroidogenesis_Homo sapiens_hsa049130.87151392
64African trypanosomiasis_Homo sapiens_hsa051430.86843281
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86778626
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84125625
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83516830
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.83079050
69Graft-versus-host disease_Homo sapiens_hsa053320.82878762
70Propanoate metabolism_Homo sapiens_hsa006400.82266627
71Arginine and proline metabolism_Homo sapiens_hsa003300.80794189
72Thyroid hormone synthesis_Homo sapiens_hsa049180.80379540
73Circadian rhythm_Homo sapiens_hsa047100.80185427
74Histidine metabolism_Homo sapiens_hsa003400.79512533
75Nitrogen metabolism_Homo sapiens_hsa009100.78746281
76Tryptophan metabolism_Homo sapiens_hsa003800.77469994
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77174431
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75937438
79Peroxisome_Homo sapiens_hsa041460.75696042
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75498216
81Huntingtons disease_Homo sapiens_hsa050160.75370600
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72800776
83Bile secretion_Homo sapiens_hsa049760.69774602
84Retinol metabolism_Homo sapiens_hsa008300.69520551
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69460351
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68671528
87Fatty acid metabolism_Homo sapiens_hsa012120.67465793
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66878987
89Fatty acid degradation_Homo sapiens_hsa000710.66705740
90Glucagon signaling pathway_Homo sapiens_hsa049220.66617808
91Allograft rejection_Homo sapiens_hsa053300.66407882
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65248479
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64496397
94Oocyte meiosis_Homo sapiens_hsa041140.64000846
95Sphingolipid metabolism_Homo sapiens_hsa006000.63759054
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63377746
97GnRH signaling pathway_Homo sapiens_hsa049120.62747139
98ErbB signaling pathway_Homo sapiens_hsa040120.62446567
99Ras signaling pathway_Homo sapiens_hsa040140.61152568
100MAPK signaling pathway_Homo sapiens_hsa040100.58799348
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.58758923
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.57703036
103Pyruvate metabolism_Homo sapiens_hsa006200.54755789
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54474266
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53131914
106Regulation of autophagy_Homo sapiens_hsa041400.53131190
107Chemical carcinogenesis_Homo sapiens_hsa052040.52862179
108Gap junction_Homo sapiens_hsa045400.52518339
109Protein export_Homo sapiens_hsa030600.52443151
110Tyrosine metabolism_Homo sapiens_hsa003500.49639115
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47324946
112Glutathione metabolism_Homo sapiens_hsa004800.47287405
113Tuberculosis_Homo sapiens_hsa051520.46632571
114Metabolic pathways_Homo sapiens_hsa011000.46310532
115Ether lipid metabolism_Homo sapiens_hsa005650.45796941
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.45561856
117Asthma_Homo sapiens_hsa053100.44716022
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43547160
119Melanoma_Homo sapiens_hsa052180.43301238
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43177766
121Dilated cardiomyopathy_Homo sapiens_hsa054140.42564255
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41869035
123Pancreatic secretion_Homo sapiens_hsa049720.41649769
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39774570
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.39728648
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38856656
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38569702
128Chemokine signaling pathway_Homo sapiens_hsa040620.37560040
129Wnt signaling pathway_Homo sapiens_hsa043100.36797339
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36634075
131Linoleic acid metabolism_Homo sapiens_hsa005910.36484529
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35696693
133Melanogenesis_Homo sapiens_hsa049160.35303519
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34319769
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33976338
136Choline metabolism in cancer_Homo sapiens_hsa052310.33941189
137Estrogen signaling pathway_Homo sapiens_hsa049150.33643890
138Inositol phosphate metabolism_Homo sapiens_hsa005620.32909627
139Phenylalanine metabolism_Homo sapiens_hsa003600.31455688
140Prion diseases_Homo sapiens_hsa050200.29263897
141Hematopoietic cell lineage_Homo sapiens_hsa046400.28134539
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27542761
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.27069021
144Salmonella infection_Homo sapiens_hsa051320.26749526

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