MRAS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.20819206
2synaptic vesicle maturation (GO:0016188)6.17346493
3locomotory exploration behavior (GO:0035641)6.00963079
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.74649713
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.52327304
6vocalization behavior (GO:0071625)5.43921893
7synaptic vesicle exocytosis (GO:0016079)5.43832011
8glutamate secretion (GO:0014047)5.39406855
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.33798019
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.31297391
11regulation of synaptic vesicle exocytosis (GO:2000300)4.96728188
12regulation of glutamate receptor signaling pathway (GO:1900449)4.96419062
13protein localization to synapse (GO:0035418)4.70613190
14regulation of neuronal synaptic plasticity (GO:0048168)4.64442493
15regulation of long-term neuronal synaptic plasticity (GO:0048169)4.53839620
16exploration behavior (GO:0035640)4.52082264
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.49596616
18regulation of synapse structural plasticity (GO:0051823)4.46352146
19layer formation in cerebral cortex (GO:0021819)4.44777920
20regulation of synaptic vesicle transport (GO:1902803)4.43111087
21neurotransmitter secretion (GO:0007269)4.40284676
22neuronal action potential propagation (GO:0019227)4.38620319
23neurotransmitter-gated ion channel clustering (GO:0072578)4.36650061
24dendritic spine morphogenesis (GO:0060997)4.27630757
25neuron cell-cell adhesion (GO:0007158)4.20470779
26synaptic transmission, glutamatergic (GO:0035249)4.13736227
27proline transport (GO:0015824)4.05609917
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.03891754
29cellular potassium ion homeostasis (GO:0030007)3.98690940
30glutamate receptor signaling pathway (GO:0007215)3.95136581
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.93447368
32long-term memory (GO:0007616)3.93071381
33gamma-aminobutyric acid transport (GO:0015812)3.83643725
34neuron-neuron synaptic transmission (GO:0007270)3.83596539
35positive regulation of membrane potential (GO:0045838)3.81107720
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.79382032
37positive regulation of synapse maturation (GO:0090129)3.75018266
38regulation of synaptic plasticity (GO:0048167)3.74873735
39sodium ion export (GO:0071436)3.74304350
40positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.70434373
41regulation of dendritic spine morphogenesis (GO:0061001)3.66793321
42neuromuscular process controlling balance (GO:0050885)3.64155285
43regulation of postsynaptic membrane potential (GO:0060078)3.58993663
44auditory behavior (GO:0031223)3.57957379
45regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.54797459
46long-term synaptic potentiation (GO:0060291)3.52298115
47neurotransmitter transport (GO:0006836)3.51530073
48activation of protein kinase A activity (GO:0034199)3.50219283
49L-amino acid import (GO:0043092)3.50042015
50response to auditory stimulus (GO:0010996)3.48421992
51regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.40213831
52cell communication by electrical coupling (GO:0010644)3.36484200
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.35733317
54regulation of neurotransmitter secretion (GO:0046928)3.35535902
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.33965522
56regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.33680907
57positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.33339360
58cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.30580682
59postsynaptic membrane organization (GO:0001941)3.30512265
60positive regulation of neurotransmitter secretion (GO:0001956)3.30432526
61synaptic vesicle endocytosis (GO:0048488)3.29754849
62G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.29038820
63regulation of neurotransmitter levels (GO:0001505)3.28084899
64prepulse inhibition (GO:0060134)3.26895208
65neuron recognition (GO:0008038)3.25994317
66dendritic spine organization (GO:0097061)3.25367279
67transmission of nerve impulse (GO:0019226)3.25063675
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.24267467
69positive regulation of neurotransmitter transport (GO:0051590)3.22910338
70dendrite morphogenesis (GO:0048813)3.20762721
71regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.19893977
72regulation of vesicle fusion (GO:0031338)3.18927865
73neuromuscular process controlling posture (GO:0050884)3.18238323
74detection of calcium ion (GO:0005513)3.17225603
75cardiac muscle contraction (GO:0060048)3.16313727
76regulation of neurotransmitter transport (GO:0051588)3.14859787
77cardiac myofibril assembly (GO:0055003)3.14512722
78axonal fasciculation (GO:0007413)3.14448251
79regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.11762796
80regulation of dendritic spine development (GO:0060998)3.10275432
81innervation (GO:0060384)3.09801929
82positive regulation of synaptic transmission (GO:0050806)3.09023389
83response to histamine (GO:0034776)3.06297570
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04645886
85positive regulation of dendritic spine development (GO:0060999)3.04136500
86cellular response to epinephrine stimulus (GO:0071872)3.03580182
87gamma-aminobutyric acid signaling pathway (GO:0007214)3.02982090
88positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.02610367
89membrane depolarization (GO:0051899)3.02566656
90negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02494400
91learning (GO:0007612)3.01816455
92neuromuscular process (GO:0050905)3.00544874
93regulation of synaptic transmission (GO:0050804)3.00486771
94sarcoplasmic reticulum calcium ion transport (GO:0070296)2.99624332
95cerebellar Purkinje cell differentiation (GO:0021702)2.99446673
96neuronal ion channel clustering (GO:0045161)2.97645371
97regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.96816714
98barbed-end actin filament capping (GO:0051016)2.96490538
99low-density lipoprotein particle clearance (GO:0034383)2.96301249
100regulation of cell communication by electrical coupling (GO:0010649)2.96102742
101membrane hyperpolarization (GO:0060081)2.94933384
102behavioral defense response (GO:0002209)2.94203021
103behavioral fear response (GO:0001662)2.94203021
104cerebellar granule cell differentiation (GO:0021707)2.92764241
105membrane depolarization during action potential (GO:0086010)2.91788246
106glycine transport (GO:0015816)2.91606881
107cell migration in hindbrain (GO:0021535)2.91408880
108amino acid import (GO:0043090)2.91084828
109vesicle transport along microtubule (GO:0047496)2.90156111
110regulation of voltage-gated calcium channel activity (GO:1901385)2.88756264
111G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.88714156
112social behavior (GO:0035176)2.88024391
113intraspecies interaction between organisms (GO:0051703)2.88024391
114regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.86366591
115muscle filament sliding (GO:0030049)2.84127106
116actin-myosin filament sliding (GO:0033275)2.84127106
117cell communication involved in cardiac conduction (GO:0086065)2.76807526
118regulation of actin filament-based movement (GO:1903115)2.73458625
119myofibril assembly (GO:0030239)2.73428591
120response to dietary excess (GO:0002021)2.72498833
121negative regulation of amino acid transport (GO:0051956)2.62585879
122response to epinephrine (GO:0071871)2.60523016
123regulation of cholesterol storage (GO:0010885)2.59323691
124protein heterotrimerization (GO:0070208)2.54663905
125cellular response to monoamine stimulus (GO:0071868)2.52595863
126cellular response to catecholamine stimulus (GO:0071870)2.52595863
127striated muscle contraction (GO:0006941)2.51179042
128regulation of sequestering of triglyceride (GO:0010889)2.49132849
129sarcomere organization (GO:0045214)2.49113656
130regulation of cardiac muscle cell contraction (GO:0086004)2.48096877
131regulation of cAMP-dependent protein kinase activity (GO:2000479)2.48059399
132cardiac muscle hypertrophy (GO:0003300)2.47571959
133regulation of membrane repolarization (GO:0060306)2.43808208
134apoptotic cell clearance (GO:0043277)2.42456066
135regulation of the force of heart contraction (GO:0002026)2.41082557
136cytoskeletal anchoring at plasma membrane (GO:0007016)2.39566913
137actin-mediated cell contraction (GO:0070252)2.39297384
138adhesion of symbiont to host cell (GO:0044650)2.38108647
139virion attachment to host cell (GO:0019062)2.38108647
140cGMP-mediated signaling (GO:0019934)2.38063537
141striated muscle hypertrophy (GO:0014897)2.35311633
142cell migration involved in heart development (GO:0060973)2.35017727
143stress fiber assembly (GO:0043149)2.33492025
144response to inactivity (GO:0014854)2.33426676
145membrane assembly (GO:0071709)2.32681171
146potassium ion homeostasis (GO:0055075)2.31054967
147acylglycerol catabolic process (GO:0046464)2.30004022
148neutral lipid catabolic process (GO:0046461)2.30004022
149triglyceride catabolic process (GO:0019433)2.29764762
150adenosine receptor signaling pathway (GO:0001973)2.27940757
151cardiac muscle hypertrophy in response to stress (GO:0014898)2.27640773
152muscle hypertrophy in response to stress (GO:0003299)2.27640773
153cardiac muscle adaptation (GO:0014887)2.27640773
154regulation of striated muscle contraction (GO:0006942)2.26690118
155regulation of calcium ion transmembrane transporter activity (GO:1901019)2.26003262
156regulation of calcium ion transmembrane transport (GO:1903169)2.26003262
157cAMP biosynthetic process (GO:0006171)2.23961500
158regulation of integrin-mediated signaling pathway (GO:2001044)2.22579297
159response to gravity (GO:0009629)2.21126404
160positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.19441110
161response to catecholamine (GO:0071869)2.18756471
162response to monoamine (GO:0071867)2.18756471
163potassium ion import (GO:0010107)2.17594284
164muscle cell cellular homeostasis (GO:0046716)2.14806125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.69409546
2* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13312347
3GBX2_23144817_ChIP-Seq_PC3_Human3.10640774
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02703773
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02234387
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81029580
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81029580
8* RARB_27405468_Chip-Seq_BRAIN_Mouse2.80945970
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.74411938
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.74139472
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68623231
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61295258
13DROSHA_22980978_ChIP-Seq_HELA_Human2.60776186
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54059142
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53959418
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51728135
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48474790
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.48393534
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.39163838
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.28451364
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.27362949
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26096370
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.23996457
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.20836132
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.17015532
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15828036
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11766254
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07467808
29RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03468566
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94407769
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.92843254
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91945783
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91653501
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.84091395
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82728293
36AR_21572438_ChIP-Seq_LNCaP_Human1.77652822
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67400576
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.57948180
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54401974
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46556929
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46212844
42RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44854543
43SMAD4_21799915_ChIP-Seq_A2780_Human1.44650738
44* RING1B_27294783_Chip-Seq_ESCs_Mouse1.41269584
45CLOCK_20551151_ChIP-Seq_293T_Human1.40352657
46TBX20_22080862_ChIP-Seq_HEART_Mouse1.39701249
47TBX20_22328084_ChIP-Seq_HEART_Mouse1.39701249
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39344232
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37134195
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.34476422
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32926725
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30486337
53KDM2B_26808549_Chip-Seq_K562_Human1.30444795
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29881362
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27462995
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.26292802
57WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25160219
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25072817
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.24669674
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22539496
61* AR_19668381_ChIP-Seq_PC3_Human1.22333506
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21878624
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20228519
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19981044
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19484008
66ZNF274_21170338_ChIP-Seq_K562_Hela1.16932304
67* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14970416
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13306290
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13209338
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.12579351
71AR_25329375_ChIP-Seq_VCAP_Human1.11459306
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11022639
73NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10606640
74STAT3_23295773_ChIP-Seq_U87_Human1.09327318
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08719233
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08577001
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.08073869
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07401017
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07401017
80P300_19829295_ChIP-Seq_ESCs_Human1.07390327
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05847003
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05841382
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05350353
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04336734
85WT1_19549856_ChIP-ChIP_CCG9911_Human1.03434553
86RXR_22108803_ChIP-Seq_LS180_Human1.02660191
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02535837
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01932426
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00091918
90ARNT_22903824_ChIP-Seq_MCF-7_Human0.99890789
91CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99808297
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99566932
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98949830
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98508903
95SMAD3_21741376_ChIP-Seq_HESCs_Human0.98221315
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97495326
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97463310
98AHR_22903824_ChIP-Seq_MCF-7_Human0.97147942
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96712105
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96682661
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96476874
102PIAS1_25552417_ChIP-Seq_VCAP_Human0.96305639
103GATA2_21666600_ChIP-Seq_HMVEC_Human0.96221231
104ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95854988
105TP53_20018659_ChIP-ChIP_R1E_Mouse0.95021015
106TP53_23651856_ChIP-Seq_MEFs_Mouse0.94245741
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.93915214
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93713817
109TET1_21490601_ChIP-Seq_MESCs_Mouse0.93678592
110TP53_16413492_ChIP-PET_HCT116_Human0.92601881
111TCF4_23295773_ChIP-Seq_U87_Human0.92186998
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.91458750
113* CJUN_26792858_Chip-Seq_BT549_Human0.91215066
114TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90569505
115FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90377023
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90116861
117CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90101836
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89465054
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89280309
120LXR_22292898_ChIP-Seq_THP-1_Human0.88968005
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88784584
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88575935
123TAF15_26573619_Chip-Seq_HEK293_Human0.87465701
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86785055
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85957313
126CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85554505
127SMC1_22415368_ChIP-Seq_MEFs_Mouse0.83775646
128TP53_18474530_ChIP-ChIP_U2OS_Human0.83337788
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83221213
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82185547
131RUNX2_22187159_ChIP-Seq_PCA_Human0.82120542
132* CTCF_27219007_Chip-Seq_Bcells_Human0.81283773
133RNF2_27304074_Chip-Seq_NSC_Mouse0.80738241
134SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80608651
135PRDM14_20953172_ChIP-Seq_ESCs_Human0.80492243
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.80246873
137TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79747638
138OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79574899
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79068574
140SMC3_22415368_ChIP-Seq_MEFs_Mouse0.77521654

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.97418137
2MP0003880_abnormal_central_pattern4.50063860
3MP0003635_abnormal_synaptic_transmissio4.17535865
4MP0004270_analgesia3.81564762
5MP0002063_abnormal_learning/memory/cond3.39872757
6MP0009745_abnormal_behavioral_response3.32740842
7MP0008438_abnormal_cutaneous_collagen3.11301349
8MP0002064_seizures3.11276610
9MP0002822_catalepsy3.04834179
10MP0001968_abnormal_touch/_nociception2.98388556
11MP0009046_muscle_twitch2.93654008
12MP0002572_abnormal_emotion/affect_behav2.79813989
13MP0005423_abnormal_somatic_nervous2.69477870
14MP0002734_abnormal_mechanical_nocicepti2.61128515
15MP0000749_muscle_degeneration2.56275714
16MP0001486_abnormal_startle_reflex2.53893457
17MP0003279_aneurysm2.53731390
18MP0004130_abnormal_muscle_cell2.42671178
19MP0002272_abnormal_nervous_system2.42056502
20MP0009780_abnormal_chondrocyte_physiolo2.41947615
21MP0004858_abnormal_nervous_system2.37818986
22MP0005670_abnormal_white_adipose2.34347809
23MP0002736_abnormal_nociception_after2.24247255
24MP0001501_abnormal_sleep_pattern2.17231290
25MP0004084_abnormal_cardiac_muscle2.17226150
26MP0003705_abnormal_hypodermis_morpholog2.11956173
27MP0001958_emphysema2.08773740
28MP0002733_abnormal_thermal_nociception2.07552250
29MP0001440_abnormal_grooming_behavior2.02509781
30MP0002735_abnormal_chemical_nociception1.97717923
31MP0001970_abnormal_pain_threshold1.97448892
32MP0008569_lethality_at_weaning1.91519279
33MP0002909_abnormal_adrenal_gland1.89608529
34MP0003329_amyloid_beta_deposits1.89033485
35MP0003950_abnormal_plasma_membrane1.88747055
36MP0004036_abnormal_muscle_relaxation1.84955419
37MP0002837_dystrophic_cardiac_calcinosis1.82172064
38MP0002067_abnormal_sensory_capabilities1.82088054
39MP0000778_abnormal_nervous_system1.81277436
40MP0004811_abnormal_neuron_physiology1.79108460
41MP0004510_myositis1.76816426
42MP0002557_abnormal_social/conspecific_i1.75374248
43MP0004885_abnormal_endolymph1.70822708
44MP0005646_abnormal_pituitary_gland1.70236048
45MP0005503_abnormal_tendon_morphology1.70054344
46MP0005386_behavior/neurological_phenoty1.67766382
47MP0004924_abnormal_behavior1.67766382
48MP0002184_abnormal_innervation1.63413343
49MP0005058_abnormal_lysosome_morphology1.63249046
50MP0003879_abnormal_hair_cell1.59751919
51MP0004087_abnormal_muscle_fiber1.57549308
52MP0002972_abnormal_cardiac_muscle1.55592969
53MP0000955_abnormal_spinal_cord1.53853946
54MP0000343_altered_response_to1.53767506
55MP0000747_muscle_weakness1.51955873
56MP0002971_abnormal_brown_adipose1.50747184
57MP0000759_abnormal_skeletal_muscle1.48508119
58MP0005620_abnormal_muscle_contractility1.48158773
59MP0003633_abnormal_nervous_system1.44595517
60MP0005666_abnormal_adipose_tissue1.43295507
61MP0005275_abnormal_skin_tensile1.40236088
62MP0002882_abnormal_neuron_morphology1.38821760
63MP0003828_pulmonary_edema1.38624451
64MP0002066_abnormal_motor_capabilities/c1.37294444
65MP0001542_abnormal_bone_strength1.35466317
66MP0001984_abnormal_olfaction1.35299410
67MP0005595_abnormal_vascular_smooth1.31615215
68MP0000750_abnormal_muscle_regeneration1.29952413
69MP0009840_abnormal_foam_cell1.29480466
70MP0006138_congestive_heart_failure1.27851237
71MP0001502_abnormal_circadian_rhythm1.24586730
72MP0003787_abnormal_imprinting1.24446676
73MP0002295_abnormal_pulmonary_circulatio1.23149099
74MP0005645_abnormal_hypothalamus_physiol1.21853732
75MP0005375_adipose_tissue_phenotype1.21432244
76MP0003631_nervous_system_phenotype1.20077788
77MP0000767_abnormal_smooth_muscle1.19689145
78MP0004272_abnormal_basement_membrane1.17547412
79MP0005623_abnormal_meninges_morphology1.16627531
80MP0003283_abnormal_digestive_organ1.15268284
81MP0002152_abnormal_brain_morphology1.14359455
82MP0006276_abnormal_autonomic_nervous1.14039016
83MP0003191_abnormal_cellular_cholesterol1.12630744
84MP0002269_muscular_atrophy1.12528281
85MP0000569_abnormal_digit_pigmentation1.12044667
86MP0003075_altered_response_to1.11477960
87MP0001905_abnormal_dopamine_level1.11115678
88MP0009384_cardiac_valve_regurgitation1.09259897
89MP0005385_cardiovascular_system_phenoty1.08285973
90MP0001544_abnormal_cardiovascular_syste1.08285973
91MP0002108_abnormal_muscle_morphology1.07660764
92MP0003690_abnormal_glial_cell1.06111248
93MP0003091_abnormal_cell_migration1.05789012
94MP0003634_abnormal_glial_cell1.05159626
95MP0005165_increased_susceptibility_to1.05098682
96MP0005330_cardiomyopathy1.03686566
97MP0000751_myopathy1.01802842
98MP0002106_abnormal_muscle_physiology1.00905189
99MP0004142_abnormal_muscle_tone0.99946175
100MP0000013_abnormal_adipose_tissue0.97711898
101MP0001177_atelectasis0.96149057
102MP0001529_abnormal_vocalization0.95253087
103MP0002896_abnormal_bone_mineralization0.94599235
104MP0005369_muscle_phenotype0.94199402
105MP0008872_abnormal_physiological_respon0.94159381
106MP0003122_maternal_imprinting0.93831975
107MP0010386_abnormal_urinary_bladder0.93775178
108MP0002069_abnormal_eating/drinking_beha0.91551341
109MP0005257_abnormal_intraocular_pressure0.91141395
110MP0000733_abnormal_muscle_development0.89124540
111MP0008874_decreased_physiological_sensi0.85039850
112MP0003632_abnormal_nervous_system0.84950321
113MP0002332_abnormal_exercise_endurance0.84768560
114MP0001188_hyperpigmentation0.83244100
115MP0010630_abnormal_cardiac_muscle0.82849729
116MP0005388_respiratory_system_phenotype0.81975868
117MP0002133_abnormal_respiratory_system0.81975868
118MP0003566_abnormal_cell_adhesion0.81790565
119MP0000003_abnormal_adipose_tissue0.81551238
120MP0002229_neurodegeneration0.81531575
121MP0005167_abnormal_blood-brain_barrier0.81321241
122MP0001963_abnormal_hearing_physiology0.76685839
123MP0002090_abnormal_vision0.75977606
124MP0000604_amyloidosis0.75752474
125MP0002653_abnormal_ependyma_morphology0.74826887
126MP0004085_abnormal_heartbeat0.74820442
127MP0000631_abnormal_neuroendocrine_gland0.74730931
128MP0005499_abnormal_olfactory_system0.73726631
129MP0005394_taste/olfaction_phenotype0.73726631
130MP0004145_abnormal_muscle_electrophysio0.71657179
131MP0005551_abnormal_eye_electrophysiolog0.71304846
132MP0000920_abnormal_myelination0.70206725
133MP0001485_abnormal_pinna_reflex0.69754975
134MP0004233_abnormal_muscle_weight0.69423984
135MP0005535_abnormal_body_temperature0.69183256
136MP0001299_abnormal_eye_distance/0.68641468
137MP0008961_abnormal_basal_metabolism0.65486298
138MP0002752_abnormal_somatic_nervous0.64877696
139MP0003045_fibrosis0.62155267
140MP0003861_abnormal_nervous_system0.61656658
141MP0004742_abnormal_vestibular_system0.60931073
142MP0001943_abnormal_respiration0.58985295
143MP0003137_abnormal_impulse_conducting0.57819727
144MP0004043_abnormal_pH_regulation0.56444064
145MP0003172_abnormal_lysosome_physiology0.55792959
146MP0002089_abnormal_postnatal_growth/wei0.55598667
147MP0000534_abnormal_ureter_morphology0.53687023
148MP0002638_abnormal_pupillary_reflex0.53443985
149MP0004484_altered_response_of0.52496172
150MP0001664_abnormal_digestion0.52415193
151MP0010769_abnormal_survival0.51658209
152MP0004215_abnormal_myocardial_fiber0.51095553
153MP0010768_mortality/aging0.47736557

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.36461139
2Myokymia (HP:0002411)7.08873117
3Focal seizures (HP:0007359)5.51790918
4Visual hallucinations (HP:0002367)4.84752053
5Epileptic encephalopathy (HP:0200134)4.78764703
6Action tremor (HP:0002345)4.27524799
7Atonic seizures (HP:0010819)4.24207536
8Progressive cerebellar ataxia (HP:0002073)3.95657181
9Febrile seizures (HP:0002373)3.91995293
10Absence seizures (HP:0002121)3.89422931
11Generalized tonic-clonic seizures (HP:0002069)3.74811562
12Protrusio acetabuli (HP:0003179)3.72731044
13Sudden death (HP:0001699)3.72237154
14Dialeptic seizures (HP:0011146)3.59394503
15Type 1 muscle fiber predominance (HP:0003803)3.50839020
16Hyporeflexia of lower limbs (HP:0002600)3.45886320
17Ankle clonus (HP:0011448)3.44144818
18Supranuclear gaze palsy (HP:0000605)3.28926838
19Megalencephaly (HP:0001355)3.24755997
20Abnormality of glycolipid metabolism (HP:0010969)3.24309567
21Abnormality of liposaccharide metabolism (HP:0010968)3.24309567
22Abnormality of glycosphingolipid metabolism (HP:0004343)3.24309567
23Broad-based gait (HP:0002136)3.21412705
24Depression (HP:0000716)3.20029395
25Impaired vibration sensation in the lower limbs (HP:0002166)3.18827136
26Asymmetric septal hypertrophy (HP:0001670)3.17357712
27Dysdiadochokinesis (HP:0002075)3.14769220
28Poor eye contact (HP:0000817)3.14062729
29Premature rupture of membranes (HP:0001788)3.11253273
30Muscle fiber splitting (HP:0003555)3.10470253
31Increased variability in muscle fiber diameter (HP:0003557)3.06179469
32Gaze-evoked nystagmus (HP:0000640)2.96327845
33Hyperventilation (HP:0002883)2.95718514
34Abnormal eating behavior (HP:0100738)2.94878125
35Urinary bladder sphincter dysfunction (HP:0002839)2.94745433
36Papilledema (HP:0001085)2.93213070
37Abnormal social behavior (HP:0012433)2.88984328
38Impaired social interactions (HP:0000735)2.88984328
39Amblyopia (HP:0000646)2.83563371
40Atrial fibrillation (HP:0005110)2.82121080
41Anxiety (HP:0000739)2.81078243
42Distal lower limb muscle weakness (HP:0009053)2.80715805
43Gowers sign (HP:0003391)2.78515974
44Genetic anticipation (HP:0003743)2.78440479
45Dysmetria (HP:0001310)2.78125970
46Truncal ataxia (HP:0002078)2.76532736
47Hemiparesis (HP:0001269)2.73702612
48Abnormality of the lower motor neuron (HP:0002366)2.73581267
49Torticollis (HP:0000473)2.71975210
50Postural instability (HP:0002172)2.71880513
51Mutism (HP:0002300)2.71385738
52Annular pancreas (HP:0001734)2.65861212
53Primary atrial arrhythmia (HP:0001692)2.65134181
54Abnormality of skeletal muscle fiber size (HP:0012084)2.60559042
55Urinary urgency (HP:0000012)2.58260851
56Abnormal atrioventricular conduction (HP:0005150)2.58231693
57Hemiplegia (HP:0002301)2.57895598
58Heart block (HP:0012722)2.57240753
59Popliteal pterygium (HP:0009756)2.56750459
60Aortic aneurysm (HP:0004942)2.54434842
61Supraventricular tachycardia (HP:0004755)2.54301320
62Abnormality of the calf musculature (HP:0001430)2.53193957
63Akinesia (HP:0002304)2.52888761
64Supraventricular arrhythmia (HP:0005115)2.51748879
65Insidious onset (HP:0003587)2.48872381
66Termporal pattern (HP:0011008)2.48872381
67Focal dystonia (HP:0004373)2.48791692
68Aplasia of the phalanges of the hand (HP:0009802)2.48786341
69Aplasia involving bones of the extremities (HP:0009825)2.48786341
70Aplasia involving bones of the upper limbs (HP:0009823)2.48786341
71Stereotypic behavior (HP:0000733)2.48117602
72Vascular tortuosity (HP:0004948)2.47976812
73Excessive salivation (HP:0003781)2.46870847
74Drooling (HP:0002307)2.46870847
75Impaired smooth pursuit (HP:0007772)2.46434732
76Lipoatrophy (HP:0100578)2.44898646
77Nemaline bodies (HP:0003798)2.43838414
78Atrioventricular block (HP:0001678)2.43792532
79Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.43647790
80Cerebral aneurysm (HP:0004944)2.42934587
81Abnormality of binocular vision (HP:0011514)2.40914161
82Diplopia (HP:0000651)2.40914161
83Neurofibrillary tangles (HP:0002185)2.40176262
84Intention tremor (HP:0002080)2.36905817
85Cerebral inclusion bodies (HP:0100314)2.36888165
86Bradykinesia (HP:0002067)2.36678987
87Syncope (HP:0001279)2.33754017
88Axonal loss (HP:0003447)2.32845649
89Prolonged QT interval (HP:0001657)2.32688629
90Muscle fiber inclusion bodies (HP:0100299)2.30003081
91Aortic dissection (HP:0002647)2.29934641
92Aplasia of the musculature (HP:0100854)2.28744899
93Spinal rigidity (HP:0003306)2.28185826
94Status epilepticus (HP:0002133)2.25862208
95Hypoplastic heart (HP:0001961)2.24344426
96Arterial tortuosity (HP:0005116)2.23820065
97Spastic gait (HP:0002064)2.23104460
98Epileptiform EEG discharges (HP:0011182)2.22886223
99Round ear (HP:0100830)2.21927436
100Pointed chin (HP:0000307)2.21614215
101Obstructive sleep apnea (HP:0002870)2.21171488
102Impaired vibratory sensation (HP:0002495)2.20277127
103Craniofacial dystonia (HP:0012179)2.18115242
104Difficulty running (HP:0009046)2.17022638
105Dysmetric saccades (HP:0000641)2.16685366
106EMG: myopathic abnormalities (HP:0003458)2.15852059
107Progressive inability to walk (HP:0002505)2.15623021
108Abnormality of ocular smooth pursuit (HP:0000617)2.15109829
109Lower limb muscle weakness (HP:0007340)2.14164459
110Dysostosis multiplex (HP:0000943)2.13806039
111EEG with generalized epileptiform discharges (HP:0011198)2.12746727
112Vertebral compression fractures (HP:0002953)2.12403776
113Ventricular arrhythmia (HP:0004308)2.11164669
114Bulbar palsy (HP:0001283)2.11001596
115Fetal akinesia sequence (HP:0001989)2.10084520
116Ventricular fibrillation (HP:0001663)2.07340588
117Scanning speech (HP:0002168)2.04780222
118Hypsarrhythmia (HP:0002521)2.03620046
119Fatigable weakness (HP:0003473)2.02851775
120Abnormality of the neuromuscular junction (HP:0003398)2.02851775
121Nuclear cataract (HP:0100018)2.02186220
122Bladder diverticulum (HP:0000015)2.01631207
123Exercise-induced myalgia (HP:0003738)2.01561331
124Frequent falls (HP:0002359)2.00938232
125Limb dystonia (HP:0002451)2.00255650
126Mildly elevated creatine phosphokinase (HP:0008180)2.00175469
127Absent speech (HP:0001344)2.00051527
128Bradycardia (HP:0001662)1.99762573
129Neck muscle weakness (HP:0000467)1.99670308
130Weak cry (HP:0001612)1.98990740
131Calf muscle hypertrophy (HP:0008981)1.96616511
132Pheochromocytoma (HP:0002666)1.96000927
133Skin nodule (HP:0200036)1.94448132
134Foot dorsiflexor weakness (HP:0009027)1.93920209
135Bundle branch block (HP:0011710)1.93176496
136Polyphagia (HP:0002591)1.92953877
137Insomnia (HP:0100785)1.92894003
138Diminished motivation (HP:0000745)1.92411677
139Lower limb amyotrophy (HP:0007210)1.91343694
140Lower limb asymmetry (HP:0100559)1.89751890
141Type 2 muscle fiber atrophy (HP:0003554)1.89444290
142Increased connective tissue (HP:0009025)1.89266157
143Generalized myoclonic seizures (HP:0002123)1.89088140
144Abnormality of the foot musculature (HP:0001436)1.88684937
145Incomplete penetrance (HP:0003829)1.88053071
146Thin ribs (HP:0000883)1.88034827
147Resting tremor (HP:0002322)1.85082411
148Gait ataxia (HP:0002066)1.84914577
149Mitral regurgitation (HP:0001653)1.84890684
150Ankle contracture (HP:0006466)1.83457735
151Ankyloglossia (HP:0010296)1.83197935
152Scapular winging (HP:0003691)1.82223607
153Overgrowth (HP:0001548)1.82199772
154Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82119737
155Abnormality of polysaccharide metabolism (HP:0011012)1.82119737
156Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82119737
157Hypoventilation (HP:0002791)1.79657063
158Infantile muscular hypotonia (HP:0008947)1.79520654
159Postural tremor (HP:0002174)1.78424941
160Mucopolysacchariduria (HP:0008155)1.78013644
161Urinary glycosaminoglycan excretion (HP:0003541)1.78013644
162Abnormality of the periventricular white matter (HP:0002518)1.77614829
163Respiratory insufficiency due to muscle weakness (HP:0002747)1.77518945
164Apathy (HP:0000741)1.76802573
165Neuronal loss in central nervous system (HP:0002529)1.75119347
166Agitation (HP:0000713)1.73625490
167Clonus (HP:0002169)1.71416665
168Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.71224852
169Bronchomalacia (HP:0002780)1.70496378
170Abnormal EKG (HP:0003115)1.67426750
171Rapidly progressive (HP:0003678)1.67388393
172Abnormality of the corticospinal tract (HP:0002492)1.67049553
173Amyotrophic lateral sclerosis (HP:0007354)1.66820457
174Inability to walk (HP:0002540)1.66811516
175Rigidity (HP:0002063)1.66639190
176Neoplasm of the peripheral nervous system (HP:0100007)1.65774294

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.98754856
2NTRK34.20401671
3MAP3K93.82701829
4PRKD32.93328921
5MARK12.88844810
6DAPK22.82149614
7MAP3K42.71196818
8MINK12.59828499
9MUSK2.56847771
10MYLK2.44723265
11PAK62.36509769
12KSR22.24457557
13MAP2K72.15978115
14NTRK22.15160729
15CAMKK12.05610006
16NTRK12.03822061
17LIMK11.97753175
18TTN1.90494994
19DAPK11.69116885
20KSR11.62399064
21CASK1.61331564
22PRPF4B1.60936074
23RIPK41.60326307
24OBSCN1.58453743
25CDK51.56875023
26MAP2K41.55354813
27TESK11.55077123
28ARAF1.53536464
29PLK21.49179424
30TGFBR21.48413401
31MAP3K121.45310293
32GRK71.44613117
33STK381.43040009
34MAPK121.41284218
35TYRO31.40522623
36GRK51.36067970
37MAP3K21.32246281
38TNIK1.30029175
39NEK91.21835055
40PRKCG1.20512577
41CDK191.18760630
42LATS21.15041840
43SIK21.14877809
44ABL21.14578769
45TAOK11.13839967
46MAPK131.13808707
47EPHB21.06892011
48CAMKK21.05916393
49ROCK11.03672760
50PHKG11.01575818
51PHKG21.01575818
52SGK4940.98754785
53SGK2230.98754785
54PNCK0.97762996
55UHMK10.97729896
56PKN10.97677913
57CDK180.95145618
58CDK150.94280505
59DDR20.92867964
60LMTK20.92698476
61CDK140.92415134
62MAP3K130.92235511
63SGK20.89713578
64FES0.88126862
65CAMK2A0.88050256
66PINK10.87931945
67STK110.87721685
68PAK20.86901174
69ALK0.85326936
70PRKCH0.84771634
71RET0.84541245
72CAMK1G0.83877884
73SGK30.83511493
74PTK2B0.82370290
75CAMK10.82183860
76MAPK40.82100518
77CDK11A0.81387761
78PAK30.80815244
79RAF10.78930721
80TAOK20.77214503
81CAMK1D0.72448720
82PDGFRB0.70231638
83PTK20.68982507
84CAMK2B0.68475214
85SGK10.67506220
86NEK10.67131531
87PDPK10.65869922
88PDK10.65566148
89AKT30.65268951
90BMPR20.65148516
91PIK3CG0.64438849
92MAP3K50.63840197
93RPS6KA20.62149790
94PRKD10.61895735
95TRIB30.61518607
96RIPK10.59717841
97MAPK70.57934928
98DYRK1A0.56341146
99CDC42BPA0.54141795
100PRKCZ0.52902054
101MARK20.51339905
102DAPK30.50788122
103MAP3K10.50586569
104MAP2K10.50130215
105RPS6KA30.49780815
106PRKG10.49471301
107MAP3K110.49422431
108DMPK0.49001509
109FER0.48142749
110IRAK30.48141861
111BRSK10.47324729
112PRKCE0.47305138
113TNK20.47207167
114OXSR10.47061173
115PDK20.47027379
116CSNK1G20.46070653
117MAPK100.45415245
118MAP3K60.45222539
119PRKAA20.45028425
120WNK10.44004428
121CAMK40.43296557
122PIM20.43067106
123NME10.42911340
124PDGFRA0.41677330
125NEK60.41222988
126PRKD20.40795097
127BMX0.40653411
128FGR0.40247788
129CAMK2G0.38725369
130BRAF0.38381499
131CAMK2D0.36403389
132SCYL20.36152094
133FYN0.35719991
134MOS0.33728518
135ROCK20.31921129

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.33272901
2Synaptic vesicle cycle_Homo sapiens_hsa047213.20790326
3Olfactory transduction_Homo sapiens_hsa047402.77540642
4Circadian entrainment_Homo sapiens_hsa047132.60686452
5Long-term potentiation_Homo sapiens_hsa047202.59226787
6GABAergic synapse_Homo sapiens_hsa047272.56119120
7Glutamatergic synapse_Homo sapiens_hsa047242.48746624
8Amphetamine addiction_Homo sapiens_hsa050312.43886563
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41236926
10Morphine addiction_Homo sapiens_hsa050322.32878047
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30102187
12Nitrogen metabolism_Homo sapiens_hsa009102.28993777
13Salivary secretion_Homo sapiens_hsa049702.12621849
14Dopaminergic synapse_Homo sapiens_hsa047282.08317593
15Insulin secretion_Homo sapiens_hsa049112.05196904
16Gastric acid secretion_Homo sapiens_hsa049711.89796069
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.87013928
18Cholinergic synapse_Homo sapiens_hsa047251.86929452
19PPAR signaling pathway_Homo sapiens_hsa033201.70659581
20Cocaine addiction_Homo sapiens_hsa050301.65410674
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65349923
22Oxytocin signaling pathway_Homo sapiens_hsa049211.63700284
23Renin secretion_Homo sapiens_hsa049241.58215322
24Long-term depression_Homo sapiens_hsa047301.57134722
25Taste transduction_Homo sapiens_hsa047421.52365653
26Calcium signaling pathway_Homo sapiens_hsa040201.50827057
27Serotonergic synapse_Homo sapiens_hsa047261.46541493
28GnRH signaling pathway_Homo sapiens_hsa049121.46509793
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42054255
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41305314
31Gap junction_Homo sapiens_hsa045401.37314475
32Lysosome_Homo sapiens_hsa041421.34624870
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33253640
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.28612385
35Glioma_Homo sapiens_hsa052141.28236480
36ECM-receptor interaction_Homo sapiens_hsa045121.26915136
37cAMP signaling pathway_Homo sapiens_hsa040241.25596021
38Collecting duct acid secretion_Homo sapiens_hsa049661.23843790
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23778238
40Estrogen signaling pathway_Homo sapiens_hsa049151.21537740
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17328455
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14922800
43Focal adhesion_Homo sapiens_hsa045101.14659596
44Melanogenesis_Homo sapiens_hsa049161.12524372
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11385730
46ErbB signaling pathway_Homo sapiens_hsa040121.10495537
47Type II diabetes mellitus_Homo sapiens_hsa049301.10041885
48Axon guidance_Homo sapiens_hsa043601.08428348
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07661347
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02573843
51Dorso-ventral axis formation_Homo sapiens_hsa043200.98709892
52Other glycan degradation_Homo sapiens_hsa005110.96817678
53Amoebiasis_Homo sapiens_hsa051460.91741391
54Oocyte meiosis_Homo sapiens_hsa041140.91258243
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.89784492
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88830896
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85818852
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84738543
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.84248971
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84143667
61* Phospholipase D signaling pathway_Homo sapiens_hsa040720.83769194
62Vitamin B6 metabolism_Homo sapiens_hsa007500.82961621
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80549878
64Vibrio cholerae infection_Homo sapiens_hsa051100.79971381
65AMPK signaling pathway_Homo sapiens_hsa041520.77887060
66Dilated cardiomyopathy_Homo sapiens_hsa054140.77710329
67Thyroid hormone synthesis_Homo sapiens_hsa049180.76720683
68Cardiac muscle contraction_Homo sapiens_hsa042600.76428233
69Pancreatic secretion_Homo sapiens_hsa049720.76319417
70Choline metabolism in cancer_Homo sapiens_hsa052310.72935393
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72861353
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.72399225
73mTOR signaling pathway_Homo sapiens_hsa041500.71065584
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69959961
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69426339
76VEGF signaling pathway_Homo sapiens_hsa043700.68966387
77* MAPK signaling pathway_Homo sapiens_hsa040100.67666134
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66801482
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66282701
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65576161
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62890738
82Circadian rhythm_Homo sapiens_hsa047100.62530594
83* Rap1 signaling pathway_Homo sapiens_hsa040150.61894461
84Phototransduction_Homo sapiens_hsa047440.61878819
85beta-Alanine metabolism_Homo sapiens_hsa004100.61775534
86Phenylalanine metabolism_Homo sapiens_hsa003600.61682641
87Phagosome_Homo sapiens_hsa041450.61384993
88Glycerolipid metabolism_Homo sapiens_hsa005610.60370359
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59233209
90Endocytosis_Homo sapiens_hsa041440.59186230
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58680747
92Glucagon signaling pathway_Homo sapiens_hsa049220.58588492
93* Ras signaling pathway_Homo sapiens_hsa040140.57628927
94Fatty acid metabolism_Homo sapiens_hsa012120.57427135
95Endometrial cancer_Homo sapiens_hsa052130.57313506
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.57029377
97Protein digestion and absorption_Homo sapiens_hsa049740.56389654
98Histidine metabolism_Homo sapiens_hsa003400.56072391
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55895771
100Fatty acid elongation_Homo sapiens_hsa000620.54697087
101Pertussis_Homo sapiens_hsa051330.54543538
102* Proteoglycans in cancer_Homo sapiens_hsa052050.54446728
103Wnt signaling pathway_Homo sapiens_hsa043100.54061104
104Malaria_Homo sapiens_hsa051440.53996859
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53544675
106Pyruvate metabolism_Homo sapiens_hsa006200.53025018
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51670782
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51476573
109Renal cell carcinoma_Homo sapiens_hsa052110.50545219
110Prion diseases_Homo sapiens_hsa050200.50367904
111Non-small cell lung cancer_Homo sapiens_hsa052230.49729282
112Alcoholism_Homo sapiens_hsa050340.49424164
113Type I diabetes mellitus_Homo sapiens_hsa049400.47271773
114Insulin signaling pathway_Homo sapiens_hsa049100.46775771
115Bile secretion_Homo sapiens_hsa049760.46119584
116Inositol phosphate metabolism_Homo sapiens_hsa005620.45370625
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45108371
118African trypanosomiasis_Homo sapiens_hsa051430.42614141
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42226094
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41815157
121Fatty acid biosynthesis_Homo sapiens_hsa000610.41763645
122Ovarian steroidogenesis_Homo sapiens_hsa049130.41573878
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40191088
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35800685
125Hedgehog signaling pathway_Homo sapiens_hsa043400.35457038
126Colorectal cancer_Homo sapiens_hsa052100.34168884
127Hippo signaling pathway_Homo sapiens_hsa043900.33951215
128Chemokine signaling pathway_Homo sapiens_hsa040620.31627861
129* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31374581
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28986603

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