MRC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)7.13182211
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.13182211
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.13182211
4positive regulation by organism of defense response of other organism involved in symbiotic interact7.13182211
5modulation by symbiont of host immune response (GO:0052553)7.13182211
6positive regulation by symbiont of host defense response (GO:0052509)7.13182211
7regulation of interferon-beta biosynthetic process (GO:0045357)6.19226484
8macrophage activation involved in immune response (GO:0002281)5.71122241
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.70098641
10glycosphingolipid catabolic process (GO:0046479)5.56471517
11positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.56220182
12microglial cell activation (GO:0001774)5.36617727
13eosinophil chemotaxis (GO:0048245)5.18001264
14oligosaccharide catabolic process (GO:0009313)5.11473651
15virion attachment to host cell (GO:0019062)5.09337833
16adhesion of symbiont to host cell (GO:0044650)5.09337833
17neutrophil activation involved in immune response (GO:0002283)5.01579913
18glycolipid catabolic process (GO:0019377)5.00772922
19pinocytosis (GO:0006907)4.82279272
20ceramide catabolic process (GO:0046514)4.79502062
21adhesion of symbiont to host (GO:0044406)4.60383581
22positive regulation of interferon-alpha production (GO:0032727)4.57997517
23eosinophil migration (GO:0072677)4.54901986
24response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.44373220
25response to host immune response (GO:0052572)4.44373220
26regulation of interferon-alpha production (GO:0032647)4.31679350
27macrophage activation (GO:0042116)4.22664030
28regulation of cholesterol storage (GO:0010885)4.12724073
29amino sugar catabolic process (GO:0046348)4.08000606
30immunoglobulin mediated immune response (GO:0016064)4.02586589
31response to host (GO:0075136)3.96298777
32response to host defenses (GO:0052200)3.96298777
33response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.96298777
34positive regulation of cellular amide metabolic process (GO:0034250)3.85661902
35membrane lipid catabolic process (GO:0046466)3.85288652
36response to peptidoglycan (GO:0032494)3.76694499
37positive regulation of gamma-delta T cell activation (GO:0046645)3.76566692
38regulation of interleukin-8 biosynthetic process (GO:0045414)3.75021823
39sphingolipid catabolic process (GO:0030149)3.71598066
40negative regulation of granulocyte differentiation (GO:0030853)3.65248105
41myeloid cell activation involved in immune response (GO:0002275)3.56643205
42negative regulation of interleukin-12 production (GO:0032695)3.56102442
43production of molecular mediator involved in inflammatory response (GO:0002532)3.54511835
44response to thyroid hormone (GO:0097066)3.52312365
45positive regulation of monocyte chemotaxis (GO:0090026)3.51198213
46positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.43430586
47regulation of mononuclear cell migration (GO:0071675)3.40382998
48regulation of B cell receptor signaling pathway (GO:0050855)3.40130437
49barbed-end actin filament capping (GO:0051016)3.38865806
50positive regulation of macrophage cytokine production (GO:0060907)3.36444500
51peptide catabolic process (GO:0043171)3.35386079
52response to lipoprotein particle (GO:0055094)3.32422955
53apoptotic cell clearance (GO:0043277)3.32249604
54positive regulation of antigen processing and presentation (GO:0002579)3.32066486
55phospholipid efflux (GO:0033700)3.31846092
56monocyte chemotaxis (GO:0002548)3.30088621
57regulation of apoptotic cell clearance (GO:2000425)3.29591736
58granulocyte chemotaxis (GO:0071621)3.29399988
59detection of molecule of bacterial origin (GO:0032490)3.27798717
60iron ion import (GO:0097286)3.26685277
61positive regulation of bone remodeling (GO:0046852)3.26480287
62positive regulation of bone resorption (GO:0045780)3.26480287
63keratan sulfate catabolic process (GO:0042340)3.26133243
64granulocyte activation (GO:0036230)3.25149428
65positive regulation of cholesterol efflux (GO:0010875)3.23594929
66positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.23448301
67I-kappaB phosphorylation (GO:0007252)3.22754257
68respiratory burst (GO:0045730)3.20660874
69positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.17017896
70granulocyte migration (GO:0097530)3.16306827
71osteoclast differentiation (GO:0030316)3.14707873
72neutrophil activation (GO:0042119)3.14496135
73macrophage differentiation (GO:0030225)3.14163416
74phagocytosis, engulfment (GO:0006911)3.13783164
75positive regulation of interferon-beta production (GO:0032728)3.13195045
76T-helper 1 type immune response (GO:0042088)3.12349091
77myeloid dendritic cell differentiation (GO:0043011)3.09032760
78negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.07965000
79negative regulation of lipid storage (GO:0010888)3.07787573
80low-density lipoprotein particle clearance (GO:0034383)3.07142244
81peptidyl-glutamic acid carboxylation (GO:0017187)3.04113208
82protein carboxylation (GO:0018214)3.04113208
83hyaluronan catabolic process (GO:0030214)3.03966996
84cellular extravasation (GO:0045123)3.03860437
85lipopolysaccharide-mediated signaling pathway (GO:0031663)3.01601717
86positive regulation of cholesterol transport (GO:0032376)3.00019384
87positive regulation of sterol transport (GO:0032373)3.00019384
88phospholipid homeostasis (GO:0055091)2.99631829
89protein localization to endosome (GO:0036010)2.98425843
90cellular response to thyroid hormone stimulus (GO:0097067)2.98296655
91lipoxygenase pathway (GO:0019372)2.97699153
92N-acetylneuraminate metabolic process (GO:0006054)2.97346370
93cellular response to ethanol (GO:0071361)2.95239313
94regulation of macrophage derived foam cell differentiation (GO:0010743)2.95005087
95phagosome maturation (GO:0090382)2.92336332
96regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.91454806
97regulation of myeloid leukocyte mediated immunity (GO:0002886)2.89723734
98positive regulation of mast cell activation (GO:0033005)2.89311819
99triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.87578261
100regulation of hypersensitivity (GO:0002883)2.87412431
101positive regulation of chemokine secretion (GO:0090197)2.86712554
102regulation of mast cell degranulation (GO:0043304)2.85800252
103positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.85323805
104regulation of monocyte chemotaxis (GO:0090025)2.84196482
105positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.83042090
106plasma lipoprotein particle clearance (GO:0034381)2.81246941
107intracellular pH reduction (GO:0051452)2.79964651
108regulation of T-helper 2 cell differentiation (GO:0045628)2.79832883
109response to muramyl dipeptide (GO:0032495)2.79795098
110myeloid dendritic cell activation (GO:0001773)2.78852071
111regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.78577063
112complement activation, alternative pathway (GO:0006957)2.78431108
113neutrophil chemotaxis (GO:0030593)2.78172419
114regulation of macrophage chemotaxis (GO:0010758)2.76486380
115negative regulation of mast cell activation (GO:0033004)2.73770722
116positive regulation of B cell differentiation (GO:0045579)2.73696439
117mannose metabolic process (GO:0006013)2.72831465
118positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.71504227
119lipoprotein transport (GO:0042953)2.71139335
120B cell mediated immunity (GO:0019724)2.71105136
121positive regulation of tissue remodeling (GO:0034105)2.70897169
122neutrophil migration (GO:1990266)2.70650232
123regulation of antigen processing and presentation (GO:0002577)2.70587611
124regulation of mast cell activation involved in immune response (GO:0033006)2.70546022
125lymphocyte chemotaxis (GO:0048247)2.70101204
126positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.68542159
127detection of external biotic stimulus (GO:0098581)2.67121723
128detection of other organism (GO:0098543)2.67083736
129regulation of mast cell activation (GO:0033003)2.66410074
130regulation of gamma-delta T cell activation (GO:0046643)2.65704883
131positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.64705997
132pH reduction (GO:0045851)2.62731239
133myeloid leukocyte migration (GO:0097529)2.62014460
134myeloid leukocyte activation (GO:0002274)2.61711877
135lytic vacuole organization (GO:0080171)2.61276737
136lysosome organization (GO:0007040)2.61276737
137regulation of vitamin D biosynthetic process (GO:0060556)2.59894776
138regulation of monocyte differentiation (GO:0045655)2.59562303
139regulation of leukocyte degranulation (GO:0043300)2.59528282
140interferon-gamma-mediated signaling pathway (GO:0060333)2.59385012
141positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.59300720
142negative regulation of interleukin-17 production (GO:0032700)2.59119179
143cholesterol efflux (GO:0033344)2.58976506
144reverse cholesterol transport (GO:0043691)2.58672527
145regulation of lymphocyte chemotaxis (GO:1901623)2.58420883
146positive regulation of mast cell activation involved in immune response (GO:0033008)2.57917838
147positive regulation of mast cell degranulation (GO:0043306)2.57917838
148positive regulation of leukocyte degranulation (GO:0043302)2.57686743
149surfactant homeostasis (GO:0043129)2.56679689
150positive regulation of regulated secretory pathway (GO:1903307)2.56387329
151positive regulation of hemostasis (GO:1900048)2.56357621
152positive regulation of blood coagulation (GO:0030194)2.56357621
153regulation of podosome assembly (GO:0071801)2.55997041
154regulation of dendritic cell antigen processing and presentation (GO:0002604)2.55682473
155positive regulation of heat generation (GO:0031652)2.55208772
156regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.53045806
157decidualization (GO:0046697)2.51173658

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.98704369
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.95643776
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.93952542
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.61004267
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.45045412
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.03991014
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.69634888
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.04510652
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.84034154
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.69856498
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.56977763
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.48338709
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.41440926
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38847433
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.35872805
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31573116
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31339979
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.27735459
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18615379
20* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.12222241
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.09368327
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07705266
23* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse2.01311792
24VDR_24787735_ChIP-Seq_THP-1_Human2.00699818
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98910670
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.80735260
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79982873
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.79843486
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74167672
30SPI1_23127762_ChIP-Seq_K562_Human1.73743849
31PU_27001747_Chip-Seq_BMDM_Mouse1.73593449
32GATA1_22025678_ChIP-Seq_K562_Human1.64209313
33RUNX_20019798_ChIP-Seq_JUKART_Human1.64100223
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61067872
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60344785
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59697191
37SCL_19346495_ChIP-Seq_HPC-7_Human1.59439454
38SPI1_23547873_ChIP-Seq_NB4_Human1.58501038
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.55108335
40* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53199732
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51384386
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49418870
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.48802827
44* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46316052
45CLOCK_20551151_ChIP-Seq_293T_Human1.43136518
46VDR_24763502_ChIP-Seq_THP-1_Human1.40957344
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40176111
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37490650
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.36829296
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.32854562
51* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32066158
52* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29559952
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26351413
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23166448
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23051654
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21145904
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20767256
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17539856
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17135343
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16768425
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16140764
62GATA1_19941826_ChIP-Seq_K562_Human1.14284970
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13487091
64* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11182548
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10949873
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09592541
67EGR1_19032775_ChIP-ChIP_M12_Human1.07534071
68TFEB_21752829_ChIP-Seq_HELA_Human1.07366254
69MAF_26560356_Chip-Seq_TH1_Human1.05743539
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05528088
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05528088
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05269443
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05228172
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.04527691
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.03332456
76VDR_21846776_ChIP-Seq_THP-1_Human1.01534675
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00780494
78MYB_26560356_Chip-Seq_TH2_Human0.99167498
79GATA2_19941826_ChIP-Seq_K562_Human0.99141704
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99137042
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97034872
82CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96748744
83* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96730997
84GATA3_27048872_Chip-Seq_THYMUS_Human0.96276038
85* CJUN_26792858_Chip-Seq_BT549_Human0.94887625
86RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93841475
87SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92959636
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92897201
89CDX2_20551321_ChIP-Seq_CACO-2_Human0.92514598
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91684378
91GATA3_26560356_Chip-Seq_TH2_Human0.91639472
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90033355
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89229365
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.88242471
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86980836
96LXR_22292898_ChIP-Seq_THP-1_Human0.86547971
97SOX2_20726797_ChIP-Seq_SW620_Human0.85940463
98SPI1_20517297_ChIP-Seq_HL60_Human0.85046543
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84952659
100WT1_19549856_ChIP-ChIP_CCG9911_Human0.84873432
101PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84815393
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84509503
103MYB_26560356_Chip-Seq_TH1_Human0.84083596
104GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83698466
105KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82745972
106TCF7_22412390_ChIP-Seq_EML_Mouse0.81720604
107TBX20_22328084_ChIP-Seq_HEART_Mouse0.81349689
108TBX20_22080862_ChIP-Seq_HEART_Mouse0.81349689
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80964003
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80228080
111JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77885073
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77796887
113ELK3_25401928_ChIP-Seq_HUVEC_Human0.77363465
114SOX9_24532713_ChIP-Seq_HFSC_Mouse0.76338556
115GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75441507
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75006413
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74510813
118STAT1_20625510_ChIP-Seq_HELA_Human0.74374323
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.74334124
120AHR_22903824_ChIP-Seq_MCF-7_Human0.71744010

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.73600548
2MP0009840_abnormal_foam_cell3.96077932
3MP0001835_abnormal_antigen_presentation3.79108825
4MP0003191_abnormal_cellular_cholesterol3.75266397
5MP0003436_decreased_susceptibility_to3.15359699
6MP0003303_peritoneal_inflammation2.94043494
7* MP0002419_abnormal_innate_immunity2.88145524
8MP0006082_CNS_inflammation2.76909571
9MP0002148_abnormal_hypersensitivity_rea2.74930870
10MP0003172_abnormal_lysosome_physiology2.62908810
11MP0003724_increased_susceptibility_to2.59279579
12MP0003690_abnormal_glial_cell2.51120125
13MP0002254_reproductive_system_inflammat2.41984856
14MP0005000_abnormal_immune_tolerance2.40847317
15MP0000604_amyloidosis2.22722254
16MP0008004_abnormal_stomach_pH2.21380309
17MP0005025_abnormal_response_to2.16872442
18MP0005387_immune_system_phenotype2.10428624
19MP0001790_abnormal_immune_system2.10428624
20* MP0002452_abnormal_antigen_presenting2.05488943
21MP0004510_myositis2.05006784
22MP0009785_altered_susceptibility_to2.04755502
23MP0005464_abnormal_platelet_physiology2.04512598
24MP0008438_abnormal_cutaneous_collagen2.02952945
25MP0000569_abnormal_digit_pigmentation2.01890337
26MP0003705_abnormal_hypodermis_morpholog2.00736699
27MP0001533_abnormal_skeleton_physiology1.92584388
28MP0000343_altered_response_to1.89450896
29MP0001800_abnormal_humoral_immune1.86789640
30MP0002723_abnormal_immune_serum1.85169996
31MP0003195_calcinosis1.80676451
32MP0001958_emphysema1.67687453
33MP0002405_respiratory_system_inflammati1.64671826
34MP0003075_altered_response_to1.64074665
35MP0010368_abnormal_lymphatic_system1.63169573
36MP0008469_abnormal_protein_level1.59925985
37MP0005451_abnormal_body_composition1.57201700
38* MP0001819_abnormal_immune_cell1.56333248
39MP0009764_decreased_sensitivity_to1.55871521
40* MP0002420_abnormal_adaptive_immunity1.55641071
41MP0005671_abnormal_response_to1.54211851
42MP0000685_abnormal_immune_system1.53001469
43MP0001545_abnormal_hematopoietic_system1.51820152
44MP0005397_hematopoietic_system_phenotyp1.51820152
45MP0001845_abnormal_inflammatory_respons1.50180096
46MP0003300_gastrointestinal_ulcer1.48600464
47MP0002998_abnormal_bone_remodeling1.47246356
48MP0002139_abnormal_hepatobiliary_system1.47021379
49MP0010329_abnormal_lipoprotein_level1.46861758
50MP0005647_abnormal_sex_gland1.45636253
51MP0001853_heart_inflammation1.44597814
52MP0003448_altered_tumor_morphology1.41736681
53MP0005310_abnormal_salivary_gland1.38539933
54MP0005670_abnormal_white_adipose1.36208061
55MP0003329_amyloid_beta_deposits1.33781966
56MP0005360_urolithiasis1.33071232
57MP0005166_decreased_susceptibility_to1.32065280
58MP0005174_abnormal_tail_pigmentation1.28772361
59MP0003656_abnormal_erythrocyte_physiolo1.27811240
60MP0003828_pulmonary_edema1.27343016
61MP0004130_abnormal_muscle_cell1.24471788
62MP0001851_eye_inflammation1.20863774
63MP0003183_abnormal_peptide_metabolism1.20234158
64MP0000609_abnormal_liver_physiology1.18791768
65MP0000465_gastrointestinal_hemorrhage1.18183496
66MP0004947_skin_inflammation1.17242210
67MP0003091_abnormal_cell_migration1.16115879
68MP0005167_abnormal_blood-brain_barrier1.13882956
69MP0002877_abnormal_melanocyte_morpholog1.10131366
70MP0005164_abnormal_response_to1.08462529
71MP0005365_abnormal_bile_salt1.06300883
72MP0003453_abnormal_keratinocyte_physiol1.04430950
73MP0009763_increased_sensitivity_to1.03951907
74MP0002837_dystrophic_cardiac_calcinosis1.02996358
75MP0000716_abnormal_immune_system1.02359669
76MP0003279_aneurysm1.01566391
77MP0003806_abnormal_nucleotide_metabolis1.00919594
78MP0000689_abnormal_spleen_morphology0.99749736
79MP0010155_abnormal_intestine_physiology0.99048494
80MP0005085_abnormal_gallbladder_physiolo0.98139700
81MP0004782_abnormal_surfactant_physiolog0.96621463
82MP0009278_abnormal_bone_marrow0.96549668
83MP0002971_abnormal_brown_adipose0.96496287
84MP0004019_abnormal_vitamin_homeostasis0.96286292
85MP0005165_increased_susceptibility_to0.96133391
86MP0004883_abnormal_blood_vessel0.95495649
87MP0002090_abnormal_vision0.94508273
88MP0001881_abnormal_mammary_gland0.94435057
89MP0005083_abnormal_biliary_tract0.93374949
90MP0008875_abnormal_xenobiotic_pharmacok0.93042224
91MP0006054_spinal_hemorrhage0.92711779
92MP0000249_abnormal_blood_vessel0.91650445
93MP0003566_abnormal_cell_adhesion0.90948251
94MP0005275_abnormal_skin_tensile0.90821807
95MP0005257_abnormal_intraocular_pressure0.89997325
96MP0000371_diluted_coat_color0.89585163
97MP0010234_abnormal_vibrissa_follicle0.89455260
98MP0005390_skeleton_phenotype0.89023083
99MP0003252_abnormal_bile_duct0.88796622
100MP0000767_abnormal_smooth_muscle0.87731473
101MP0005076_abnormal_cell_differentiation0.87613062
102MP0001542_abnormal_bone_strength0.85756128
103MP0002295_abnormal_pulmonary_circulatio0.84339840
104MP0002118_abnormal_lipid_homeostasis0.83094536
105MP0010307_abnormal_tumor_latency0.81618891
106MP0002166_altered_tumor_susceptibility0.81506161
107MP0002136_abnormal_kidney_physiology0.81040730
108MP0002429_abnormal_blood_cell0.81010606
109MP0000920_abnormal_myelination0.80033423
110MP0000858_altered_metastatic_potential0.78758588
111MP0001879_abnormal_lymphatic_vessel0.78629440
112MP0009333_abnormal_splenocyte_physiolog0.78559665
113MP0000015_abnormal_ear_pigmentation0.77711365
114MP0002138_abnormal_hepatobiliary_system0.77445367
115MP0003634_abnormal_glial_cell0.77078711
116MP0003795_abnormal_bone_structure0.75254339
117MP0008874_decreased_physiological_sensi0.75170150
118MP0002277_abnormal_respiratory_mucosa0.73984673
119MP0002896_abnormal_bone_mineralization0.73746381
120MP0002398_abnormal_bone_marrow0.73686573
121MP0005319_abnormal_enzyme/_coenzyme0.72836790
122MP0005334_abnormal_fat_pad0.72404916
123MP0002933_joint_inflammation0.71496016
124MP0009115_abnormal_fat_cell0.71427245
125MP0005595_abnormal_vascular_smooth0.66348594
126MP0008260_abnormal_autophagy0.63284015
127MP0005023_abnormal_wound_healing0.63134326

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.29622075
2Recurrent abscess formation (HP:0002722)6.03662145
3Glomerulonephritis (HP:0000099)5.99932338
4Recurrent bacterial skin infections (HP:0005406)5.52880934
5Complement deficiency (HP:0004431)5.49124032
6Increased cerebral lipofuscin (HP:0011813)5.31670829
7Recurrent gram-negative bacterial infections (HP:0005420)5.26129546
8Vacuolated lymphocytes (HP:0001922)5.25663144
9Eczematoid dermatitis (HP:0000976)5.12164075
10Abnormality of complement system (HP:0005339)4.81846258
11Increased neuronal autofluorescent lipopigment (HP:0002074)4.52400645
12Dysostosis multiplex (HP:0000943)4.47633693
13Myocardial infarction (HP:0001658)4.26219509
14Axonal loss (HP:0003447)4.18940912
15Mutism (HP:0002300)4.02060789
16Disinhibition (HP:0000734)4.01926164
17Abnormality of macrophages (HP:0004311)3.93293758
18Joint hemorrhage (HP:0005261)3.88586580
19Nephritis (HP:0000123)3.67783636
20Abnormality of liposaccharide metabolism (HP:0010968)3.65653925
21Abnormality of glycosphingolipid metabolism (HP:0004343)3.65653925
22Abnormality of glycolipid metabolism (HP:0010969)3.65653925
23Spontaneous hematomas (HP:0007420)3.64118306
24Thick nail (HP:0001805)3.52009941
25Urinary glycosaminoglycan excretion (HP:0003541)3.35625121
26Mucopolysacchariduria (HP:0008155)3.35625121
27Recurrent skin infections (HP:0001581)3.31596513
28Abnormality of glycosaminoglycan metabolism (HP:0004371)3.16320623
29Abnormality of mucopolysaccharide metabolism (HP:0011020)3.16320623
30Abnormality of polysaccharide metabolism (HP:0011012)3.16320623
31Gingivitis (HP:0000230)3.16212746
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.14221008
33Osteolytic defects of the hand bones (HP:0009699)3.08369458
34Osteolytic defects of the phalanges of the hand (HP:0009771)3.08369458
35Upper motor neuron abnormality (HP:0002127)3.08136311
36Hematochezia (HP:0002573)3.07676016
37Protuberant abdomen (HP:0001538)3.03376922
38Nuclear cataract (HP:0100018)2.94111694
39Abnormality of the vasculature of the conjunctiva (HP:0008054)2.89497559
40Peripheral demyelination (HP:0011096)2.88992435
41Apathy (HP:0000741)2.87790030
42Mediastinal lymphadenopathy (HP:0100721)2.86611606
43Diminished motivation (HP:0000745)2.85968130
44Prostate neoplasm (HP:0100787)2.84500358
45Myositis (HP:0100614)2.76326045
46Xanthomatosis (HP:0000991)2.74408503
47Periodontitis (HP:0000704)2.74133460
48Conjunctival telangiectasia (HP:0000524)2.71909111
49Agnosia (HP:0010524)2.71520149
50Orchitis (HP:0100796)2.69889619
51Hypoalphalipoproteinemia (HP:0003233)2.59748958
52Autoimmune thrombocytopenia (HP:0001973)2.56177089
53Neuronal loss in central nervous system (HP:0002529)2.51378744
54Loss of speech (HP:0002371)2.50347159
55Colitis (HP:0002583)2.49710960
56Metaphyseal irregularity (HP:0003025)2.47911066
57Recurrent fungal infections (HP:0002841)2.46920056
58Neurofibrillary tangles (HP:0002185)2.45458077
59Pustule (HP:0200039)2.44789830
60Purpura (HP:0000979)2.44386796
61Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.43771455
62Progressive neurologic deterioration (HP:0002344)2.43045113
63Abnormality of the periventricular white matter (HP:0002518)2.40015115
64Pathologic fracture (HP:0002756)2.36849891
65Hepatosplenomegaly (HP:0001433)2.35706715
66Retinal atrophy (HP:0001105)2.30732144
67Retrobulbar optic neuritis (HP:0100654)2.27933593
68Optic neuritis (HP:0100653)2.27933593
69Hypercholesterolemia (HP:0003124)2.27672669
70Abnormality of the lumbar spine (HP:0100712)2.24476568
71Chronic obstructive pulmonary disease (HP:0006510)2.21549583
72Obstructive lung disease (HP:0006536)2.21549583
73Steatorrhea (HP:0002570)2.21202934
74Progressive visual loss (HP:0000529)2.20093966
75Abnormality of the common coagulation pathway (HP:0010990)2.19744015
76Deep venous thrombosis (HP:0002625)2.19037660
77Asymmetric septal hypertrophy (HP:0001670)2.15307643
78Increased CSF protein (HP:0002922)2.14977511
79Bone pain (HP:0002653)2.13572234
80Amyloidosis (HP:0011034)2.13036382
81Osteomyelitis (HP:0002754)2.12601374
82Thoracic kyphosis (HP:0002942)2.09510816
83Recurrent viral infections (HP:0004429)2.09220534
84Cardiomegaly (HP:0001640)2.09151987
85Esophageal varix (HP:0002040)2.06867415
86Dementia (HP:0000726)2.06788573
87Elevated erythrocyte sedimentation rate (HP:0003565)2.06305955
88Skin nodule (HP:0200036)2.05111686
89Premature loss of primary teeth (HP:0006323)2.03617043
90Prolonged partial thromboplastin time (HP:0003645)2.02101137
91Personality changes (HP:0000751)2.01192051
92Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00031081
93Urticaria (HP:0001025)1.99796587
94Basal ganglia calcification (HP:0002135)1.98592745
95Cellulitis (HP:0100658)1.96954085
96Stomatitis (HP:0010280)1.96868368
97Inappropriate behavior (HP:0000719)1.96054777
98Inflammation of the large intestine (HP:0002037)1.94769947
99Gingival bleeding (HP:0000225)1.89936930
100Epistaxis (HP:0000421)1.88926833
101Nausea (HP:0002018)1.88588170
102Cerebral inclusion bodies (HP:0100314)1.87437042
103Cerebral aneurysm (HP:0004944)1.87226812
104Tetraparesis (HP:0002273)1.86429807
105J-shaped sella turcica (HP:0002680)1.85555625
106Arterial tortuosity (HP:0005116)1.85020593
107Interstitial pulmonary disease (HP:0006530)1.85016045
108Global brain atrophy (HP:0002283)1.84730318
109Hemoptysis (HP:0002105)1.84156767
110Arterial thrombosis (HP:0004420)1.83919772
111Petechiae (HP:0000967)1.83243657
112Increased serum ferritin (HP:0003281)1.82623672
113Recurrent cutaneous fungal infections (HP:0011370)1.81066380
114Chronic mucocutaneous candidiasis (HP:0002728)1.81066380
115Segmental peripheral demyelination/remyelination (HP:0003481)1.80492450
116Pulmonary infiltrates (HP:0002113)1.78430348
117Vertebral compression fractures (HP:0002953)1.77055054
118Thin bony cortex (HP:0002753)1.76945156
119Facial diplegia (HP:0001349)1.76514170
120Multiple lipomas (HP:0001012)1.76389182
121Mucosal telangiectasiae (HP:0100579)1.76116294
122Spinal muscular atrophy (HP:0007269)1.75865356
123Epidermoid cyst (HP:0200040)1.74948624
124Gastrointestinal inflammation (HP:0004386)1.74796646
125Mitral stenosis (HP:0001718)1.74285998
126Malnutrition (HP:0004395)1.73670604
127Albinism (HP:0001022)1.72593169
128Prolonged neonatal jaundice (HP:0006579)1.70189119

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK6.02776501
2TGFBR24.59592058
3TYK23.25082158
4RIPK43.17784350
5MAP3K142.86391805
6SCYL22.58704863
7GRK72.55699952
8ERN12.31065380
9TBK12.24634035
10IRAK42.07260749
11CAMK1D2.06034213
12MAP4K11.92473058
13TAOK31.89288602
14JAK11.83702254
15MAP3K101.82837891
16CSF1R1.71856955
17STK101.70996830
18NEK91.67061647
19KIT1.65030657
20CDC42BPA1.62331231
21PDK21.60957715
22IRAK31.59644801
23RIPK11.57220959
24PRPF4B1.55941076
25MOS1.52658271
26DDR21.51349583
27ACVR1B1.50539785
28IKBKB1.49889699
29CSK1.48200074
30JAK21.42622398
31KDR1.36059013
32TTN1.34492541
33EPHB11.34448554
34CAMK1G1.32211805
35FGR1.30171614
36MAP2K31.27054819
37FES1.26966803
38TRIB31.26592377
39ZAP701.23467113
40JAK31.21562409
41IKBKE1.20039978
42HCK1.19990858
43CLK11.18105572
44LYN1.09521133
45ARAF1.08205108
46MAP3K11.07159915
47MAP3K31.03699095
48TAOK20.99168466
49LCK0.98066935
50RPS6KA20.96334366
51KSR20.94398572
52LIMK10.92369309
53EGFR0.91615991
54SYK0.91300619
55MAP3K110.90256068
56CDK60.89361603
57TRPM70.88461180
58BMX0.82500679
59PIM20.82307516
60BTK0.80462392
61ABL20.80117319
62PTK60.77053342
63CHUK0.76360873
64EIF2AK20.75792777
65MAP2K60.74827475
66SGK30.74471749
67GRK50.73113522
68BMPR20.71999629
69MAP3K50.70360555
70TEC0.69694388
71TIE10.68051115
72MATK0.67126078
73FGFR30.66224306
74PBK0.65535275
75PRKCD0.65202600
76SIK20.64554440
77PIK3CG0.64149775
78RPS6KL10.63450803
79RPS6KC10.63450803
80PDGFRB0.63054554
81TAOK10.61459257
82MAPK70.61242072
83MAP2K20.60671483
84CAMKK20.60419513
85ITK0.59881250
86FGFR40.59555908
87PKN20.59085519
88ABL10.58497671
89MAP3K90.57958367
90PRKG20.57908883
91GSK3A0.57560248
92MAP3K60.56735499
93TXK0.56611811
94NUAK10.56468734
95YES10.55195667
96IGF1R0.54040103
97SGK20.53655994
98DAPK20.51608175
99FYN0.50773256
100PDK10.50642337
101PAK40.50451355
102CAMKK10.50098339
103FER0.50044353
104RPS6KA60.49172687
105MARK30.47219793
106MAPK120.47022937
107TESK20.46517853
108TESK10.46233704
109MAP3K130.46169081
110CDK90.45949489
111PIM10.44946413
112DMPK0.42386011
113IRAK20.42172814
114STK240.42025800
115INSRR0.40905210
116PKN10.40831175
117MAP3K80.40558962
118INSR0.40265627
119IRAK10.39965223
120MAPKAPK20.39344821
121MAPK150.39210630
122PTK2B0.39053001
123PDPK10.38006356
124EPHA30.36101710
125MST1R0.35643587
126SIK10.35107748
127STK30.32131528
128PRKAA20.31670799
129MAP3K20.31433207
130PAK20.30703496
131NME20.30534571
132ADRBK20.29987416

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051505.35051674
2Lysosome_Homo sapiens_hsa041423.37260268
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.18150037
4Complement and coagulation cascades_Homo sapiens_hsa046103.16447086
5Other glycan degradation_Homo sapiens_hsa005112.57535378
6Leishmaniasis_Homo sapiens_hsa051402.44777926
7Osteoclast differentiation_Homo sapiens_hsa043802.39872782
8Pertussis_Homo sapiens_hsa051332.20982266
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.13836696
10Caffeine metabolism_Homo sapiens_hsa002322.07229331
11* Tuberculosis_Homo sapiens_hsa051521.93527361
12Malaria_Homo sapiens_hsa051441.93240630
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92110485
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.84998434
15* Phagosome_Homo sapiens_hsa041451.84503424
16Autoimmune thyroid disease_Homo sapiens_hsa053201.80462666
17Legionellosis_Homo sapiens_hsa051341.65123166
18Rheumatoid arthritis_Homo sapiens_hsa053231.63314656
19Type I diabetes mellitus_Homo sapiens_hsa049401.60875664
20Nitrogen metabolism_Homo sapiens_hsa009101.60091842
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.50441406
22B cell receptor signaling pathway_Homo sapiens_hsa046621.46934437
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40844084
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40737176
25Prion diseases_Homo sapiens_hsa050201.30480303
26Antigen processing and presentation_Homo sapiens_hsa046121.26878586
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25803428
28Salmonella infection_Homo sapiens_hsa051321.25478563
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21094750
30ABC transporters_Homo sapiens_hsa020101.20129508
31Measles_Homo sapiens_hsa051621.20097162
32PPAR signaling pathway_Homo sapiens_hsa033201.18923835
33Toxoplasmosis_Homo sapiens_hsa051451.17713109
34Chemokine signaling pathway_Homo sapiens_hsa040621.16901969
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11392143
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10301283
37Galactose metabolism_Homo sapiens_hsa000521.09124137
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07776045
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07009895
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04322083
41Graft-versus-host disease_Homo sapiens_hsa053321.01221586
42Vibrio cholerae infection_Homo sapiens_hsa051101.01204590
43Influenza A_Homo sapiens_hsa051640.99672312
44Apoptosis_Homo sapiens_hsa042100.97633876
45Arginine biosynthesis_Homo sapiens_hsa002200.87967834
46Hematopoietic cell lineage_Homo sapiens_hsa046400.87604012
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87454693
48TNF signaling pathway_Homo sapiens_hsa046680.86163693
49Histidine metabolism_Homo sapiens_hsa003400.85655607
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84907712
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.83917527
52African trypanosomiasis_Homo sapiens_hsa051430.83402526
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79219198
54Amoebiasis_Homo sapiens_hsa051460.77927298
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.74985905
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74883403
57Sulfur metabolism_Homo sapiens_hsa009200.74480872
58Shigellosis_Homo sapiens_hsa051310.74021704
59Renin-angiotensin system_Homo sapiens_hsa046140.72690216
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.71226404
61Asthma_Homo sapiens_hsa053100.71198684
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69117441
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68976636
64Allograft rejection_Homo sapiens_hsa053300.68969735
65Fatty acid degradation_Homo sapiens_hsa000710.68067973
66Starch and sucrose metabolism_Homo sapiens_hsa005000.66872593
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65321325
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64838914
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64502514
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63656354
71Endocytosis_Homo sapiens_hsa041440.61618688
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61303512
73Platelet activation_Homo sapiens_hsa046110.58431861
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57067935
75Prolactin signaling pathway_Homo sapiens_hsa049170.56642045
76Hepatitis C_Homo sapiens_hsa051600.56210608
77Fat digestion and absorption_Homo sapiens_hsa049750.56148614
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55711381
79Sphingolipid metabolism_Homo sapiens_hsa006000.55710625
80Viral myocarditis_Homo sapiens_hsa054160.55664207
81Chemical carcinogenesis_Homo sapiens_hsa052040.55559224
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.53684200
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53181158
84Tryptophan metabolism_Homo sapiens_hsa003800.52904805
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52434718
86Collecting duct acid secretion_Homo sapiens_hsa049660.51748552
87beta-Alanine metabolism_Homo sapiens_hsa004100.51124214
88Peroxisome_Homo sapiens_hsa041460.48669146
89Pentose phosphate pathway_Homo sapiens_hsa000300.48594093
90Hepatitis B_Homo sapiens_hsa051610.47928728
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47441146
92Acute myeloid leukemia_Homo sapiens_hsa052210.47079138
93Herpes simplex infection_Homo sapiens_hsa051680.45963102
94Steroid biosynthesis_Homo sapiens_hsa001000.45860439
95Fatty acid metabolism_Homo sapiens_hsa012120.43683520
96Insulin resistance_Homo sapiens_hsa049310.42209680
97Fatty acid biosynthesis_Homo sapiens_hsa000610.42060714
98Fructose and mannose metabolism_Homo sapiens_hsa000510.41316510
99Pancreatic cancer_Homo sapiens_hsa052120.40288132
100Retinol metabolism_Homo sapiens_hsa008300.39714898
101Synaptic vesicle cycle_Homo sapiens_hsa047210.39603011
102Mineral absorption_Homo sapiens_hsa049780.38440631
103Chronic myeloid leukemia_Homo sapiens_hsa052200.37028648
104Type II diabetes mellitus_Homo sapiens_hsa049300.36424542
105Ovarian steroidogenesis_Homo sapiens_hsa049130.36038785
106Bile secretion_Homo sapiens_hsa049760.35511689
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34295771
108GnRH signaling pathway_Homo sapiens_hsa049120.33584591
109Arachidonic acid metabolism_Homo sapiens_hsa005900.32606970
110Renal cell carcinoma_Homo sapiens_hsa052110.32487334
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32355752
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32310959
113Renin secretion_Homo sapiens_hsa049240.31394346
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.31233578
115HIF-1 signaling pathway_Homo sapiens_hsa040660.30875142
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29851321
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29541335
118Ether lipid metabolism_Homo sapiens_hsa005650.29251858
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28845484
120Primary immunodeficiency_Homo sapiens_hsa053400.27944484
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.27820705
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.27730115
123Bladder cancer_Homo sapiens_hsa052190.27720858
124T cell receptor signaling pathway_Homo sapiens_hsa046600.27581490
125Dorso-ventral axis formation_Homo sapiens_hsa043200.27356693
126VEGF signaling pathway_Homo sapiens_hsa043700.26916244
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.21473322

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