MRC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)7.35104437
2collagen fibril organization (GO:0030199)6.89049869
3bone trabecula formation (GO:0060346)6.17703085
4chondrocyte proliferation (GO:0035988)6.11980304
5endodermal cell differentiation (GO:0035987)5.31917872
6neuron projection extension involved in neuron projection guidance (GO:1902284)5.31596440
7axon extension involved in axon guidance (GO:0048846)5.31596440
8sequestering of extracellular ligand from receptor (GO:0035581)5.17370638
9skin morphogenesis (GO:0043589)4.81248760
10* collagen metabolic process (GO:0032963)4.68258558
11* collagen catabolic process (GO:0030574)4.62939441
12hemidesmosome assembly (GO:0031581)4.55812554
13* multicellular organismal macromolecule metabolic process (GO:0044259)4.42354040
14metanephric mesenchyme development (GO:0072075)4.36769193
15regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.32092678
16outer ear morphogenesis (GO:0042473)4.27863016
17* multicellular organismal catabolic process (GO:0044243)4.27402260
18kidney mesenchyme development (GO:0072074)4.17873802
19mesenchymal-epithelial cell signaling (GO:0060638)4.16811729
20* multicellular organismal metabolic process (GO:0044236)4.15204688
21planar cell polarity pathway involved in neural tube closure (GO:0090179)4.14371359
22glomerular basement membrane development (GO:0032836)4.08888008
23negative regulation of fatty acid transport (GO:2000192)4.06959567
24craniofacial suture morphogenesis (GO:0097094)4.06251869
25extracellular matrix disassembly (GO:0022617)4.04681854
26type B pancreatic cell proliferation (GO:0044342)4.00156183
27plasma membrane repair (GO:0001778)3.98590939
28basement membrane organization (GO:0071711)3.97683893
29cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.96870145
30regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.92767892
31positive regulation of endothelial cell apoptotic process (GO:2000353)3.84420353
32cell adhesion mediated by integrin (GO:0033627)3.81500879
33extracellular fibril organization (GO:0043206)3.79517334
34negative regulation of chondrocyte differentiation (GO:0032331)3.77523137
35virion attachment to host cell (GO:0019062)3.70491488
36adhesion of symbiont to host cell (GO:0044650)3.70491488
37cellular response to vitamin (GO:0071295)3.66909692
38tooth mineralization (GO:0034505)3.65307717
39wound healing, spreading of epidermal cells (GO:0035313)3.62828034
40dermatan sulfate biosynthetic process (GO:0030208)3.60651880
41cell-substrate junction assembly (GO:0007044)3.60289329
42vascular endothelial growth factor signaling pathway (GO:0038084)3.58130533
43embryonic cranial skeleton morphogenesis (GO:0048701)3.57472636
44cell migration involved in heart development (GO:0060973)3.55422115
45G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.47303496
46dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.46648430
47apoptotic cell clearance (GO:0043277)3.43945893
48extracellular matrix assembly (GO:0085029)3.41595987
49protein retention in ER lumen (GO:0006621)3.39098624
50venous blood vessel morphogenesis (GO:0048845)3.38849385
51keratan sulfate catabolic process (GO:0042340)3.38670090
52fibril organization (GO:0097435)3.38153786
53barbed-end actin filament capping (GO:0051016)3.34768686
54insulin-like growth factor receptor signaling pathway (GO:0048009)3.34648890
55regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.33036627
56cellular response to vitamin D (GO:0071305)3.30752525
57hippo signaling (GO:0035329)3.30352267
58chondrocyte development (GO:0002063)3.29858999
59positive regulation of epithelial to mesenchymal transition (GO:0010718)3.29744655
60dermatan sulfate metabolic process (GO:0030205)3.26391946
61maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.26030768
62peptidyl-proline hydroxylation (GO:0019511)3.24129116
63adhesion of symbiont to host (GO:0044406)3.23611715
64cell proliferation involved in metanephros development (GO:0072203)3.22837175
65epithelial cell-cell adhesion (GO:0090136)3.20810182
66negative regulation of cartilage development (GO:0061037)3.19858187
67polarized epithelial cell differentiation (GO:0030859)3.19791204
68blood vessel maturation (GO:0001955)3.16179035
69positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.15834692
70middle ear morphogenesis (GO:0042474)3.15460472
71retina vasculature morphogenesis in camera-type eye (GO:0061299)3.13599834
72paraxial mesoderm development (GO:0048339)3.11764305
73regulation of axon extension involved in axon guidance (GO:0048841)3.11354543
74glomerular visceral epithelial cell development (GO:0072015)3.09945146
75heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.08698866
76COPI coating of Golgi vesicle (GO:0048205)3.08182039
77Golgi transport vesicle coating (GO:0048200)3.08182039
78negative regulation of catenin import into nucleus (GO:0035414)3.06543099
79endocardial cushion development (GO:0003197)3.06343839
80extracellular matrix organization (GO:0030198)3.06230493
81extracellular structure organization (GO:0043062)3.04974052
82positive regulation of mesenchymal cell proliferation (GO:0002053)3.04567555
83trabecula formation (GO:0060343)3.02116693
84negative regulation of axon extension involved in axon guidance (GO:0048843)2.98363511
85protein hydroxylation (GO:0018126)2.96799013
86chondroitin sulfate biosynthetic process (GO:0030206)2.96444413
87cell migration involved in sprouting angiogenesis (GO:0002042)2.94541624
88cellular response to amino acid stimulus (GO:0071230)2.94441200
89cochlea morphogenesis (GO:0090103)2.91673082
90negative regulation of embryonic development (GO:0045992)2.91192856
91substrate-dependent cell migration (GO:0006929)2.90767029
92protein localization to endosome (GO:0036010)2.90219605
93cranial suture morphogenesis (GO:0060363)2.90055595
94regulation of cartilage development (GO:0061035)2.89861294
95regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.89437683
96stress fiber assembly (GO:0043149)2.87746463
97negative regulation of smooth muscle cell migration (GO:0014912)2.85796908
98Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.85512697
99semaphorin-plexin signaling pathway (GO:0071526)2.83746176
100regulation of extracellular matrix disassembly (GO:0010715)2.83527726
101protein localization to cell surface (GO:0034394)2.82876530
102endothelial cell chemotaxis (GO:0035767)2.82516450
103wound healing, spreading of cells (GO:0044319)2.81864771
104regulation of chondrocyte differentiation (GO:0032330)2.81151184
105replacement ossification (GO:0036075)2.79478603
106endochondral ossification (GO:0001958)2.79478603
107adherens junction assembly (GO:0034333)2.79181899
108extracellular negative regulation of signal transduction (GO:1900116)2.78732186
109extracellular regulation of signal transduction (GO:1900115)2.78732186
110heparan sulfate proteoglycan metabolic process (GO:0030201)2.78460120
111regulation of tight junction assembly (GO:2000810)2.78247415
112substrate adhesion-dependent cell spreading (GO:0034446)2.78198415
113regulation of establishment of planar polarity (GO:0090175)2.77965312
114regulation of mesenchymal cell proliferation (GO:0010464)2.77530266
115vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.77346571
116peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.77303365
117glial cell migration (GO:0008347)2.77044193
118glomerular filtration (GO:0003094)2.76429005
119cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.76141799
120face morphogenesis (GO:0060325)2.75818945
121renal filtration (GO:0097205)2.74130927
122eye morphogenesis (GO:0048592)2.74019568
123positive regulation of cartilage development (GO:0061036)2.73204422
124endothelial cell morphogenesis (GO:0001886)2.71902493
125regulation of axon guidance (GO:1902667)2.71306912
126anatomical structure regression (GO:0060033)2.70829912
127glomerular epithelial cell development (GO:0072310)2.70120796
128positive regulation of blood vessel endothelial cell migration (GO:0043536)2.69801405
129positive regulation of axon extension (GO:0045773)2.68818581
130axon extension (GO:0048675)2.66707528
131positive regulation of receptor recycling (GO:0001921)2.62285847
132positive regulation of osteoblast proliferation (GO:0033690)2.61537278
133atrioventricular valve morphogenesis (GO:0003181)2.59420326
134establishment of planar polarity (GO:0001736)2.57513709
135establishment of tissue polarity (GO:0007164)2.57513709
136convergent extension (GO:0060026)2.56498958
137focal adhesion assembly (GO:0048041)2.54743365
138cell-substrate adherens junction assembly (GO:0007045)2.54743365
139muscle cell migration (GO:0014812)2.54004740

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.10410262
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.78140573
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.46699321
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.90905498
5CLOCK_20551151_ChIP-Seq_293T_Human3.01813795
6* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.99691998
7* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.91567946
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.85507516
9* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.59289658
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.52759734
11EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.49627874
12* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.48298602
13CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.42340366
14* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.32278680
15CJUN_26792858_Chip-Seq_BT549_Human2.25225347
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.15870663
17BRD4_25478319_ChIP-Seq_HGPS_Human2.11519577
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.01667743
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.99612468
20* ELK3_25401928_ChIP-Seq_HUVEC_Human1.95987688
21TP53_20018659_ChIP-ChIP_R1E_Mouse1.90296067
22* EED_16625203_ChIP-ChIP_MESCs_Mouse1.88476470
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.80109534
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74842843
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74842843
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68768218
27SMC1_22415368_ChIP-Seq_MEFs_Mouse1.66336565
28* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.65475527
29* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59316359
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55249531
31DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51894995
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51217406
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.50175474
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50121298
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.49246383
36ISL1_27105846_Chip-Seq_CPCs_Mouse1.48525772
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47446041
38* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46419042
39* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46419042
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44740534
41UBF1/2_26484160_Chip-Seq_HMECs_Human1.43278875
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42371418
43TP53_23651856_ChIP-Seq_MEFs_Mouse1.41349996
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40827015
45* TBX20_22080862_ChIP-Seq_HEART_Mouse1.39767301
46* TBX20_22328084_ChIP-Seq_HEART_Mouse1.39767301
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39116197
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38624274
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38406968
50* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38153345
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.37480766
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37168827
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37168827
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36067458
55TP53_22127205_ChIP-Seq_IMR90_Human1.35991812
56* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33604735
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33550673
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33228309
59* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.33152665
60* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32120298
61TP53_18474530_ChIP-ChIP_U2OS_Human1.31567628
62* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31231366
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30083184
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29768735
65TP53_16413492_ChIP-PET_HCT116_Human1.29012791
66* RNF2_27304074_Chip-Seq_ESCs_Mouse1.28944597
67* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28771013
68JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27955341
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27613055
70ATF3_27146783_Chip-Seq_COLON_Human1.26416782
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26070677
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25686298
73* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25536882
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25499479
75* KDM2B_26808549_Chip-Seq_K562_Human1.24390250
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23458970
77JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22525767
78ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.22194593
79LXR_22292898_ChIP-Seq_THP-1_Human1.19989304
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19528084
81* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19501122
82RACK7_27058665_Chip-Seq_MCF-7_Human1.19270049
83* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19007772
84MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.18504674
85* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17833210
86SMC3_22415368_ChIP-Seq_MEFs_Mouse1.17542847
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.15944549
88KDM2B_26808549_Chip-Seq_DND41_Human1.15417970
89FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.15111258
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.14468880
91SA1_22415368_ChIP-Seq_MEFs_Mouse1.13026654
92* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12919654
93RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10482556
94* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10317159
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09931423
96GATA2_21666600_ChIP-Seq_HMVEC_Human1.09570731
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09132406
98TET1_21490601_ChIP-Seq_MESCs_Mouse1.08381711
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06145864
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05583296
101* KDM2B_26808549_Chip-Seq_JURKAT_Human1.05358218
102JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04227710
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03872974
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.03405896
105P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02509900
106RING1B_27294783_Chip-Seq_ESCs_Mouse1.02478417
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02184986
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02071387
109* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01680524
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01560154
111NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00469644
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00357280
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99589759
114SOX2_20726797_ChIP-Seq_SW620_Human0.98913238
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98436838
116* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97689899
117ZNF263_19887448_ChIP-Seq_K562_Human0.96939062

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.46763443
2MP0005503_abnormal_tendon_morphology5.37414751
3MP0005275_abnormal_skin_tensile5.17091854
4MP0003705_abnormal_hypodermis_morpholog3.97006543
5MP0003279_aneurysm3.67608459
6MP0001958_emphysema3.19342739
7MP0005623_abnormal_meninges_morphology3.08792512
8MP0004272_abnormal_basement_membrane2.88226117
9MP0006054_spinal_hemorrhage2.34447756
10MP0005257_abnormal_intraocular_pressure2.34062012
11MP0005508_abnormal_skeleton_morphology2.29364154
12MP0009384_cardiac_valve_regurgitation2.23851260
13MP0010030_abnormal_orbit_morphology2.12390857
14MP0003385_abnormal_body_wall1.98278802
15MP0002060_abnormal_skin_morphology1.93059534
16MP0004858_abnormal_nervous_system1.90833287
17MP0009250_abnormal_appendicular_skeleto1.89727925
18MP0003566_abnormal_cell_adhesion1.87883632
19MP0002108_abnormal_muscle_morphology1.83267967
20MP0005023_abnormal_wound_healing1.73494897
21MP0000733_abnormal_muscle_development1.70839841
22MP0002295_abnormal_pulmonary_circulatio1.69748519
23MP0002896_abnormal_bone_mineralization1.59181708
24MP0003283_abnormal_digestive_organ1.58781581
25MP0001542_abnormal_bone_strength1.52199816
26MP0000751_myopathy1.46532292
27MP0010352_gastrointestinal_tract_polyps1.44807005
28MP0004134_abnormal_chest_morphology1.44010983
29MP0001299_abnormal_eye_distance/1.42483287
30MP0000767_abnormal_smooth_muscle1.40913712
31MP0000428_abnormal_craniofacial_morphol1.39953758
32MP0000534_abnormal_ureter_morphology1.39095283
33MP0009053_abnormal_anal_canal1.37229761
34* MP0003091_abnormal_cell_migration1.36937267
35MP0003942_abnormal_urinary_system1.34172220
36MP0001243_abnormal_dermal_layer1.33290460
37MP0002282_abnormal_trachea_morphology1.31073805
38MP0002932_abnormal_joint_morphology1.30233736
39MP0002115_abnormal_skeleton_extremities1.28618203
40MP0010368_abnormal_lymphatic_system1.27228181
41MP0000163_abnormal_cartilage_morphology1.24945524
42MP0003115_abnormal_respiratory_system1.23518952
43MP0005390_skeleton_phenotype1.21558856
44MP0005058_abnormal_lysosome_morphology1.20999095
45MP0005076_abnormal_cell_differentiation1.18541918
46MP0000013_abnormal_adipose_tissue1.18299899
47MP0003045_fibrosis1.17236205
48MP0002933_joint_inflammation1.14285976
49MP0000049_abnormal_middle_ear1.14043467
50MP0002249_abnormal_larynx_morphology1.13108547
51MP0003755_abnormal_palate_morphology1.08854502
52MP0002113_abnormal_skeleton_development1.07756554
53MP0002168_other_aberrant_phenotype1.06009411
54MP0002998_abnormal_bone_remodeling1.03617671
55MP0002877_abnormal_melanocyte_morpholog1.03444707
56MP0000750_abnormal_muscle_regeneration1.02215201
57MP0001348_abnormal_lacrimal_gland1.00114709
58MP0003950_abnormal_plasma_membrane0.96358757
59MP0002116_abnormal_craniofacial_bone0.96324219
60MP0003935_abnormal_craniofacial_develop0.95744567
61MP0005409_darkened_coat_color0.94534694
62MP0002089_abnormal_postnatal_growth/wei0.94358645
63MP0000003_abnormal_adipose_tissue0.93805356
64MP0002837_dystrophic_cardiac_calcinosis0.93715646
65MP0002109_abnormal_limb_morphology0.93582875
66MP0000432_abnormal_head_morphology0.93403942
67MP0000537_abnormal_urethra_morphology0.92115972
68MP0003937_abnormal_limbs/digits/tail_de0.91087825
69MP0000579_abnormal_nail_morphology0.90575039
70MP0003941_abnormal_skin_development0.88092255
71MP0000462_abnormal_digestive_system0.87662254
72MP0002128_abnormal_blood_circulation0.87258065
73MP0002233_abnormal_nose_morphology0.86308357
74MP0001879_abnormal_lymphatic_vessel0.84644766
75MP0000759_abnormal_skeletal_muscle0.84537870
76MP0005171_absent_coat_pigmentation0.82725726
77MP0001614_abnormal_blood_vessel0.82439381
78MP0002111_abnormal_tail_morphology0.80249091
79MP0004084_abnormal_cardiac_muscle0.78368955
80MP0004087_abnormal_muscle_fiber0.77966419
81MP0000467_abnormal_esophagus_morphology0.77825942
82MP0002925_abnormal_cardiovascular_devel0.77489901
83MP0003795_abnormal_bone_structure0.77109425
84MP0003329_amyloid_beta_deposits0.76966375
85MP0002114_abnormal_axial_skeleton0.76448913
86MP0002697_abnormal_eye_size0.76389725
87MP0001849_ear_inflammation0.75908699
88MP0000762_abnormal_tongue_morphology0.75225898
89MP0001175_abnormal_lung_morphology0.74115351
90MP0004233_abnormal_muscle_weight0.72908157
91MP0003122_maternal_imprinting0.72860478
92MP0002254_reproductive_system_inflammat0.71415577
93MP0005164_abnormal_response_to0.71042891
94MP0004185_abnormal_adipocyte_glucose0.70271845
95MP0005367_renal/urinary_system_phenotyp0.70227363
96MP0000516_abnormal_urinary_system0.70227363
97MP0001915_intracranial_hemorrhage0.69196467
98MP0005197_abnormal_uvea_morphology0.69073903
99MP0005369_muscle_phenotype0.68936502
100MP0005375_adipose_tissue_phenotype0.65943277
101MP0006138_congestive_heart_failure0.65931246
102MP0001533_abnormal_skeleton_physiology0.65705979
103MP0009840_abnormal_foam_cell0.64492049
104MP0009780_abnormal_chondrocyte_physiolo0.64073698
105MP0003634_abnormal_glial_cell0.62923308
106MP0000538_abnormal_urinary_bladder0.61491243
107MP0005193_abnormal_anterior_eye0.61353513
108MP0003300_gastrointestinal_ulcer0.61036102
109MP0005388_respiratory_system_phenotype0.60994652
110MP0002133_abnormal_respiratory_system0.60994652
111MP0003448_altered_tumor_morphology0.60905402
112MP0009278_abnormal_bone_marrow0.60686233
113MP0000749_muscle_degeneration0.60546521
114MP0005595_abnormal_vascular_smooth0.60365191
115MP0004197_abnormal_fetal_growth/weight/0.59614628
116MP0000747_muscle_weakness0.58497264
117MP0000858_altered_metastatic_potential0.57012940

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.49086429
2Premature rupture of membranes (HP:0001788)7.96204260
3Ankle contracture (HP:0006466)5.33710606
4Shallow orbits (HP:0000586)5.28777093
5Aortic dissection (HP:0002647)4.91584729
6Broad metatarsal (HP:0001783)4.86921429
7Peritonitis (HP:0002586)4.44553953
8Soft skin (HP:0000977)4.42927957
9Atrophic scars (HP:0001075)4.39584310
10Bladder diverticulum (HP:0000015)4.14652831
11Cerebral aneurysm (HP:0004944)4.13518273
12Abnormality of dentin (HP:0010299)4.02799643
13Fragile skin (HP:0001030)3.94920644
14Cervical subluxation (HP:0003308)3.81391573
15Type 1 muscle fiber predominance (HP:0003803)3.70807457
16Dilatation of the ascending aorta (HP:0005111)3.66566917
17Neonatal short-limb short stature (HP:0008921)3.61649401
18Genu recurvatum (HP:0002816)3.60303970
19Aortic aneurysm (HP:0004942)3.59508831
20Follicular hyperkeratosis (HP:0007502)3.57897783
21Mitral valve prolapse (HP:0001634)3.51201718
22Blue sclerae (HP:0000592)3.38729725
23Wrist flexion contracture (HP:0001239)3.31293365
24Vertebral compression fractures (HP:0002953)3.28716788
25Wormian bones (HP:0002645)3.16067413
26Spinal rigidity (HP:0003306)3.15531156
27Biconcave vertebral bodies (HP:0004586)3.14386673
28Increased connective tissue (HP:0009025)2.99561489
29Bowel diverticulosis (HP:0005222)2.96356319
30Slender build (HP:0001533)2.93254075
31Hyperextensible skin (HP:0000974)2.80197947
32Deviation of the hallux (HP:0010051)2.64843929
33Increased variability in muscle fiber diameter (HP:0003557)2.62726558
34Vascular tortuosity (HP:0004948)2.61695112
35Abnormal delivery (HP:0001787)2.60671716
36Mildly elevated creatine phosphokinase (HP:0008180)2.57215305
37Ulnar bowing (HP:0003031)2.55935360
38Joint laxity (HP:0001388)2.53477111
39Hallux valgus (HP:0001822)2.53335250
40Wide anterior fontanel (HP:0000260)2.50020779
41Abnormality of the acetabulum (HP:0003170)2.48922256
42Camptodactyly of toe (HP:0001836)2.48343006
43Infantile muscular hypotonia (HP:0008947)2.46730419
44Elbow flexion contracture (HP:0002987)2.44013620
45Aneurysm (HP:0002617)2.39283812
46Short 4th metacarpal (HP:0010044)2.38942925
47Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.38942925
48Mesomelia (HP:0003027)2.38689698
49Hypoventilation (HP:0002791)2.34625221
50Coronal craniosynostosis (HP:0004440)2.33829351
51Ectopia lentis (HP:0001083)2.32968472
52Broad ribs (HP:0000885)2.32049921
53Overgrowth (HP:0001548)2.29733413
54Thin bony cortex (HP:0002753)2.29530401
55Abnormality of skeletal muscle fiber size (HP:0012084)2.29193160
56Joint stiffness (HP:0001387)2.27395389
57Bell-shaped thorax (HP:0001591)2.27133353
58Arterial tortuosity (HP:0005116)2.26523505
59Abnormality of the peritoneum (HP:0002585)2.22847525
60Buphthalmos (HP:0000557)2.22812791
61Aortic valve stenosis (HP:0001650)2.20125147
62Breech presentation (HP:0001623)2.17297459
63Natal tooth (HP:0000695)2.14852663
64Disproportionate tall stature (HP:0001519)2.14712448
65Osteoarthritis (HP:0002758)2.14607204
66Mitral regurgitation (HP:0001653)2.14389806
67Spondylolisthesis (HP:0003302)2.14327695
68Round ear (HP:0100830)2.12629203
69Osteolytic defects of the hand bones (HP:0009699)2.08667466
70Osteolytic defects of the phalanges of the hand (HP:0009771)2.08667466
71Hyperacusis (HP:0010780)2.07786685
72Striae distensae (HP:0001065)2.07675114
73Broad long bones (HP:0005622)2.07236400
74Femoral bowing (HP:0002980)2.06470397
75Spinal cord lesions (HP:0100561)2.06061413
76Syringomyelia (HP:0003396)2.06061413
77Abnormality of the 4th metacarpal (HP:0010012)2.05147418
78Tibial bowing (HP:0002982)2.04418870
79Knee flexion contracture (HP:0006380)2.00755527
80Nonimmune hydrops fetalis (HP:0001790)1.99880619
81Long toe (HP:0010511)1.99249247
82Generalized amyotrophy (HP:0003700)1.97536576
83Absent frontal sinuses (HP:0002688)1.97526483
84Bowed forearm bones (HP:0003956)1.96447152
85Bowing of the arm (HP:0006488)1.96447152
86Venous insufficiency (HP:0005293)1.95605919
87Venous abnormality (HP:0002624)1.95476376
88Achilles tendon contracture (HP:0001771)1.93060520
89Hip contracture (HP:0003273)1.93041579
90Flexion contracture of toe (HP:0005830)1.92466988
91Joint contractures involving the joints of the feet (HP:0100492)1.92466988
92Morphological abnormality of the middle ear (HP:0008609)1.91920087
93Mitral stenosis (HP:0001718)1.91460107
94Short nail (HP:0001799)1.89214586
95Congenital glaucoma (HP:0001087)1.88414194
96Abnormality of skull ossification (HP:0002703)1.88057493
97Calcaneovalgus deformity (HP:0001848)1.87379199
98Flat cornea (HP:0007720)1.87037431
99Narrow nasal bridge (HP:0000446)1.87000579
100Turricephaly (HP:0000262)1.86591930
101Upper limb amyotrophy (HP:0009129)1.86296465
102Asymmetry of the thorax (HP:0001555)1.86028895
103Obstructive sleep apnea (HP:0002870)1.83620310
104Osteopenia (HP:0000938)1.83331959
105Mild short stature (HP:0003502)1.82442211
106Deformed tarsal bones (HP:0008119)1.82389229
107Inguinal hernia (HP:0000023)1.81684910
108Radial bowing (HP:0002986)1.80473578
109Protruding ear (HP:0000411)1.80415929
110Thin ribs (HP:0000883)1.79320191
111Coxa vara (HP:0002812)1.78898099
112Tarsal synostosis (HP:0008368)1.77445429
113Hypoplasia of the iris (HP:0007676)1.75863669
114Aortic regurgitation (HP:0001659)1.73880065
115Platyspondyly (HP:0000926)1.73385881
116Limb-girdle muscle weakness (HP:0003325)1.72531902
117Renal duplication (HP:0000075)1.71086588
118Delayed cranial suture closure (HP:0000270)1.69470414
119Broad face (HP:0000283)1.68965396
120Distal upper limb amyotrophy (HP:0007149)1.68856121
121Ulnar deviation of the wrist (HP:0003049)1.65811608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.35552149
2TRIB34.72556078
3PDGFRA4.14676694
4TTN4.00687959
5PKN23.25378764
6LATS13.20530889
7SIK12.98086060
8LATS22.89398661
9EPHB22.64836231
10ERN12.59149005
11RIPK12.31674064
12TGFBR22.12658645
13PAK21.88730635
14PAK41.88474964
15BMX1.87851723
16EPHA31.79323457
17EEF2K1.70257850
18PTK61.68120393
19PTK21.57559331
20MAP3K101.54022671
21PDGFRB1.47477012
22FER1.38891544
23DMPK1.37647741
24STK31.27876512
25FGFR11.27245903
26LRRK21.26848303
27MAP3K61.26533627
28TRPM71.24133192
29PAK31.21824672
30MTOR1.20293965
31CAMK1D1.14168764
32SMG11.10642968
33PTK2B1.07845365
34ROCK11.07805975
35ILK1.05478203
36FGFR21.05116707
37EPHB11.02929946
38MET1.02617417
39MYLK0.95643615
40CAMK1G0.94778878
41ICK0.94658513
42PRPF4B0.94558486
43ARAF0.93202311
44RPS6KA40.92146056
45MOS0.87007693
46PRKD20.86523242
47AKT30.86504107
48ERBB40.85832742
49MAPK70.84802001
50NEK90.84040358
51STK38L0.82975131
52ROCK20.80011928
53CDK120.77020883
54PRKCH0.76276049
55KIT0.75519647
56PIK3CA0.73853616
57MARK10.70888305
58NTRK10.70835267
59PRKD30.70498282
60IRAK30.68918558
61PRKD10.67217203
62FGFR40.65598906
63RET0.64754904
64KSR20.63788631
65TGFBR10.62774473
66CDK60.61733090
67FLT30.61482054
68JAK10.58564079
69INSR0.56870586
70MAP2K10.56300217
71LMTK20.55040790
72WNK10.54925916
73TAOK20.54058415
74ABL20.53852594
75DAPK30.53518773
76CLK10.53459824
77PRKG20.53208851
78PIM20.52497634
79CAMKK10.46700441
80SRC0.46361964
81CDC42BPA0.45828753
82MAP3K130.45444894
83CAMK2G0.44144859
84MST1R0.44141233
85ADRBK10.41755591
86DYRK1B0.41566675
87PAK10.40637655
88PAK60.40152050
89FRK0.40119634
90FGFR30.39157452
91PLK20.38813603
92STK380.36429114
93MAP3K70.36332664
94MAP2K30.35975479
95HIPK20.35634273
96JAK30.35490107
97MUSK0.35318435
98PIK3CG0.34863931
99GRK70.34598036
100SCYL20.33952456
101EPHA20.33763909
102MAPK40.33629335
103MAPKAPK30.33626557
104TESK10.32761634
105MAPK10.32698706
106ZAP700.32511392
107PDPK10.30926054
108MAP3K30.30638390
109TBK10.29927290
110CDK150.29742529
111LIMK10.29702141
112CDK11A0.29472667
113MARK20.29111386
114TYRO30.27479882
115RPS6KA20.27129360
116RPS6KC10.26249488
117RPS6KL10.26249488
118CHUK0.25677529
119GSK3A0.25472979
120MAP3K80.24724195
121CSF1R0.24380970
122RPS6KA60.23907540
123MAPKAPK20.23270003
124TAOK10.22441615
125AKT20.22114932
126IGF1R0.20832895
127ABL10.19530358

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.77113292
2Focal adhesion_Homo sapiens_hsa045103.28829494
3Protein digestion and absorption_Homo sapiens_hsa049742.87535751
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.62720670
5Proteoglycans in cancer_Homo sapiens_hsa052052.41853226
6AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.36703956
7Amoebiasis_Homo sapiens_hsa051462.33173996
8Basal cell carcinoma_Homo sapiens_hsa052172.26038157
9Bladder cancer_Homo sapiens_hsa052192.19805826
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.14035882
11Dilated cardiomyopathy_Homo sapiens_hsa054142.12169635
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.11559769
13Adherens junction_Homo sapiens_hsa045202.08264433
14Other glycan degradation_Homo sapiens_hsa005111.94837942
15Hippo signaling pathway_Homo sapiens_hsa043901.91682983
16Small cell lung cancer_Homo sapiens_hsa052221.91656758
17Malaria_Homo sapiens_hsa051441.86471857
18TGF-beta signaling pathway_Homo sapiens_hsa043501.85106263
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.83039804
20MicroRNAs in cancer_Homo sapiens_hsa052061.80111689
21Hedgehog signaling pathway_Homo sapiens_hsa043401.78497275
22Chronic myeloid leukemia_Homo sapiens_hsa052201.74526397
23PI3K-Akt signaling pathway_Homo sapiens_hsa041511.74152518
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.72490878
25Melanoma_Homo sapiens_hsa052181.63675410
26Regulation of actin cytoskeleton_Homo sapiens_hsa048101.35145274
27Glioma_Homo sapiens_hsa052141.32052628
28Pathways in cancer_Homo sapiens_hsa052001.25659408
29Axon guidance_Homo sapiens_hsa043601.22278593
30Pancreatic cancer_Homo sapiens_hsa052121.21703398
31Prostate cancer_Homo sapiens_hsa052151.21700153
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21221225
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20752147
34Wnt signaling pathway_Homo sapiens_hsa043101.19841880
35Viral myocarditis_Homo sapiens_hsa054161.15178486
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.13005464
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10942289
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.10465919
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09306572
40p53 signaling pathway_Homo sapiens_hsa041151.09224257
41Rap1 signaling pathway_Homo sapiens_hsa040151.09206668
42Platelet activation_Homo sapiens_hsa046111.04526704
43Notch signaling pathway_Homo sapiens_hsa043301.03765622
44HTLV-I infection_Homo sapiens_hsa051661.03495489
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03377429
46Tight junction_Homo sapiens_hsa045301.01104872
47Melanogenesis_Homo sapiens_hsa049160.98222372
48Central carbon metabolism in cancer_Homo sapiens_hsa052300.97215166
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96074961
50Toxoplasmosis_Homo sapiens_hsa051450.88904205
51mTOR signaling pathway_Homo sapiens_hsa041500.88568335
52Colorectal cancer_Homo sapiens_hsa052100.88228201
53Renal cell carcinoma_Homo sapiens_hsa052110.86546048
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86287516
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85542432
56Estrogen signaling pathway_Homo sapiens_hsa049150.83732890
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80103783
58TNF signaling pathway_Homo sapiens_hsa046680.79660397
59Endometrial cancer_Homo sapiens_hsa052130.74407812
60Insulin resistance_Homo sapiens_hsa049310.73914635
61HIF-1 signaling pathway_Homo sapiens_hsa040660.73664812
62Renin-angiotensin system_Homo sapiens_hsa046140.73046280
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71476735
64Pertussis_Homo sapiens_hsa051330.71277133
65Gap junction_Homo sapiens_hsa045400.70827374
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70707042
67Lysosome_Homo sapiens_hsa041420.69523214
68Galactose metabolism_Homo sapiens_hsa000520.67529105
69Shigellosis_Homo sapiens_hsa051310.67312510
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.66098413
71FoxO signaling pathway_Homo sapiens_hsa040680.65586784
72Lysine degradation_Homo sapiens_hsa003100.65207423
73Thyroid cancer_Homo sapiens_hsa052160.64925212
74GnRH signaling pathway_Homo sapiens_hsa049120.64100295
75Vibrio cholerae infection_Homo sapiens_hsa051100.62180090
76AMPK signaling pathway_Homo sapiens_hsa041520.61786856
77Non-small cell lung cancer_Homo sapiens_hsa052230.61738258
78Dorso-ventral axis formation_Homo sapiens_hsa043200.61538516
79Prolactin signaling pathway_Homo sapiens_hsa049170.61134059
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.60275980
81Endocytosis_Homo sapiens_hsa041440.59851047
82Ras signaling pathway_Homo sapiens_hsa040140.59706767
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58996270
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58807367
85Viral carcinogenesis_Homo sapiens_hsa052030.58280562
86Hepatitis B_Homo sapiens_hsa051610.58265990
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57625879
88VEGF signaling pathway_Homo sapiens_hsa043700.56264154
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.55834571
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.55501901
91Complement and coagulation cascades_Homo sapiens_hsa046100.54493643
92Salmonella infection_Homo sapiens_hsa051320.53471350
93Apoptosis_Homo sapiens_hsa042100.53415644
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.51643477
95* Phagosome_Homo sapiens_hsa041450.50595484
96Insulin signaling pathway_Homo sapiens_hsa049100.50306428
97Choline metabolism in cancer_Homo sapiens_hsa052310.49296303
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49167078
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48132589
100MAPK signaling pathway_Homo sapiens_hsa040100.48060498
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47296028
102N-Glycan biosynthesis_Homo sapiens_hsa005100.46208156
103Prion diseases_Homo sapiens_hsa050200.46160407
104Cocaine addiction_Homo sapiens_hsa050300.43814691
105Oxytocin signaling pathway_Homo sapiens_hsa049210.43718105
106Acute myeloid leukemia_Homo sapiens_hsa052210.43368783
107Ovarian steroidogenesis_Homo sapiens_hsa049130.42849094
108Osteoclast differentiation_Homo sapiens_hsa043800.41937529
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41614495
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41306824
111Thyroid hormone synthesis_Homo sapiens_hsa049180.40884648
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38745584
113ErbB signaling pathway_Homo sapiens_hsa040120.37806231
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37330295
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31564959

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