ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cysteine metabolic process (GO:0006534)	8.30589149
2	mitochondrial DNA replication (GO:0006264)	7.46032121
3	thalamus development (GO:0021794)	6.20249436
4	viral transcription (GO:0019083)	5.88566425
5	translational termination (GO:0006415)	5.58445544
6	serine family amino acid catabolic process (GO:0009071)	5.50848215
7	signal peptide processing (GO:0006465)	5.26450393
8	negative regulation of axon guidance (GO:1902668)	5.19850771
9	protein-cofactor linkage (GO:0018065)	5.15263363
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.15075629
11	somite development (GO:0061053)	5.11008740
12	positive regulation of fatty acid beta-oxidation (GO:0032000)	5.06742162
13	cotranslational protein targeting to membrane (GO:0006613)	5.05557255
14	protein targeting to ER (GO:0045047)	4.93919547
15	urogenital system development (GO:0001655)	4.93748307
16	sulfur amino acid catabolic process (GO:0000098)	4.85405254
17	mitochondrial DNA metabolic process (GO:0032042)	4.76492344
18	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.72095017
19	nonmotile primary cilium assembly (GO:0035058)	4.69771661
20	sequestering of actin monomers (GO:0042989)	4.62015447
21	protein localization to endoplasmic reticulum (GO:0070972)	4.58990835
22	translational elongation (GO:0006414)	4.49954530
23	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.44329963
24	ribosomal small subunit assembly (GO:0000028)	4.31965734
25	viral life cycle (GO:0019058)	4.27680715
26	cellular protein complex disassembly (GO:0043624)	4.20450402
27	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.17812155
28	behavioral response to nicotine (GO:0035095)	4.16810397
29	heart valve formation (GO:0003188)	4.14623686
30	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	4.12043435
31	DNA-dependent DNA replication (GO:0006261)	4.07223175
32	midbrain development (GO:0030901)	4.02626208
33	retinal ganglion cell axon guidance (GO:0031290)	3.99933623
34	otic vesicle formation (GO:0030916)	3.96634888
35	positive regulation of gastrulation (GO:2000543)	3.93861591
36	positive regulation of fatty acid oxidation (GO:0046321)	3.78048655
37	cartilage morphogenesis (GO:0060536)	3.76955515
38	ribosomal small subunit biogenesis (GO:0042274)	3.61181625
39	serine family amino acid metabolic process (GO:0009069)	3.54199210
40	protein complex disassembly (GO:0043241)	3.52669037
41	cellular response to cholesterol (GO:0071397)	3.52386130
42	synaptic transmission, cholinergic (GO:0007271)	3.47186643
43	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.45678608
44	NADH dehydrogenase complex assembly (GO:0010257)	3.45678608
45	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.45678608
46	primitive streak formation (GO:0090009)	3.42136739
47	cranial nerve development (GO:0021545)	3.40546398
48	neuron fate determination (GO:0048664)	3.36815523
49	regulation of norepinephrine secretion (GO:0014061)	3.30569348
50	macromolecular complex disassembly (GO:0032984)	3.28485934
51	T cell apoptotic process (GO:0070231)	3.27418555
52	water-soluble vitamin biosynthetic process (GO:0042364)	3.26486548
53	protein targeting to membrane (GO:0006612)	3.22895555
54	positive regulation of triglyceride biosynthetic process (GO:0010867)	3.21820344
55	spinal cord development (GO:0021510)	3.20496451
56	regulation of axon guidance (GO:1902667)	3.15258585
57	dopaminergic neuron differentiation (GO:0071542)	3.14424390
58	sulfur amino acid biosynthetic process (GO:0000097)	3.12898074
59	regulation of cilium movement (GO:0003352)	3.12608572
60	fatty acid elongation (GO:0030497)	3.08145504
61	centriole replication (GO:0007099)	3.07064776
62	mammary gland epithelial cell differentiation (GO:0060644)	3.06455013
63	serine family amino acid biosynthetic process (GO:0009070)	3.06408879
64	cellular response to sterol (GO:0036315)	3.06139940
65	intra-S DNA damage checkpoint (GO:0031573)	3.04333159
66	translational initiation (GO:0006413)	3.03687806
67	intraciliary transport (GO:0042073)	3.03093552
68	glomerulus development (GO:0032835)	3.02692680
69	lateral sprouting from an epithelium (GO:0060601)	2.98184631
70	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.97948909
71	limb bud formation (GO:0060174)	2.95795049
72	lipid particle organization (GO:0034389)	2.95778326
73	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.92246459
74	mitochondrial respiratory chain complex assembly (GO:0033108)	2.91956243
75	endocardial cushion morphogenesis (GO:0003203)	2.89766129
76	regulation of triglyceride catabolic process (GO:0010896)	2.84907206
77	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.82546216
78	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.82056725
79	ER overload response (GO:0006983)	2.80995240
80	negative regulation of response to food (GO:0032096)	2.78838902
81	negative regulation of appetite (GO:0032099)	2.78838902
82	intracellular protein transmembrane import (GO:0044743)	2.78427123
83	axon ensheathment in central nervous system (GO:0032291)	2.78242346
84	central nervous system myelination (GO:0022010)	2.78242346
85	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.78036290
86	respiratory tube development (GO:0030323)	2.77368177
87	axon extension involved in axon guidance (GO:0048846)	2.76697023
88	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.76697023
89	lymphocyte apoptotic process (GO:0070227)	2.76310676
90	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.74565494
91	protein complex biogenesis (GO:0070271)	2.74073832
92	transmission of nerve impulse (GO:0019226)	2.73365878
93	mRNA catabolic process (GO:0006402)	2.72388815
94	negative regulation of axon extension (GO:0030517)	2.69606243
95	lactation (GO:0007595)	2.69242128
96	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.65526241
97	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.63635363
98	cellular ketone body metabolic process (GO:0046950)	2.62475558
99	neuronal stem cell maintenance (GO:0097150)	2.61665059
100	photoreceptor cell maintenance (GO:0045494)	2.61461158

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.40250757
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.85736513
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.97110003
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.60417655
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.53386148
6	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.52716759
7	VDR_22108803_ChIP-Seq_LS180_Human	2.48931469
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.35135306
9	EWS_26573619_Chip-Seq_HEK293_Human	2.20012207
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.11201682
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08100086
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.04059652
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.98665939
14	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.95432037
15	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.94518073
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.88718403
17	ELK1_19687146_ChIP-ChIP_HELA_Human	1.84022298
18	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.83189945
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.77276520
20	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.72242605
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.71018200
22	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.70052874
23	FUS_26573619_Chip-Seq_HEK293_Human	1.69330192
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.67776055
25	P300_19829295_ChIP-Seq_ESCs_Human	1.67034692
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.63132517
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.62013457
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.60695543
29	BCAT_22108803_ChIP-Seq_LS180_Human	1.58815391
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.52554258
31	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.50598220
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50566030
33	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.50566030
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.48263239
35	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.47738486
36	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.46454848
37	NANOG_19829295_ChIP-Seq_ESCs_Human	1.45378821
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.45378821
39	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.44883350
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42780993
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.41187829
42	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.41137535
43	NCOR_22424771_ChIP-Seq_293T_Human	1.40330107
44	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.38210478
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37836058
46	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.36768371
47	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.36233455
48	REST_21632747_ChIP-Seq_MESCs_Mouse	1.35845138
49	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.35036872
50	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.34690493
51	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.33713448
52	TCF4_22108803_ChIP-Seq_LS180_Human	1.31769459
53	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.29848846
54	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.29392008
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.28585931
56	AR_21572438_ChIP-Seq_LNCaP_Human	1.27192531
57	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.25185252
58	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.25107364
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23987508
60	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.23841568
61	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.23841568
62	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23481386
63	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.22926659
64	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.22580186
65	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.22328425
66	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.20699549
67	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19584856
68	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18557934
69	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16433817
70	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.15884267
71	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15713133
72	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.15422364
73	TP53_22573176_ChIP-Seq_HFKS_Human	1.14946926
74	GBX2_23144817_ChIP-Seq_PC3_Human	1.14937287
75	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.14600996
76	MYC_18940864_ChIP-ChIP_HL60_Human	1.11868439
77	TAF15_26573619_Chip-Seq_HEK293_Human	1.11488901
78	IGF1R_20145208_ChIP-Seq_DFB_Human	1.11152844
79	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.10985769
80	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06880613
81	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06880613
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06594680
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06495644
84	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.06415020
85	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.06402512
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04861306
87	AR_20517297_ChIP-Seq_VCAP_Human	1.02469693
88	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.02159521
89	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02006022
90	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.01847310
91	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.01352517
92	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.01319566
93	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01064730
94	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00766574
95	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00059439
96	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.99841121
97	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99590700
98	ER_23166858_ChIP-Seq_MCF-7_Human	0.97829017
99	IRF1_19129219_ChIP-ChIP_H3396_Human	0.97437899
100	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97187818

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.87958263
2	MP0001529_abnormal_vocalization	3.83130014
3	MP0009379_abnormal_foot_pigmentation	3.70993661
4	MP0003880_abnormal_central_pattern	3.08976784
5	MP0005085_abnormal_gallbladder_physiolo	2.49417879
6	MP0006292_abnormal_olfactory_placode	2.37647426
7	MP0002234_abnormal_pharynx_morphology	2.32745115
8	MP0002653_abnormal_ependyma_morphology	2.21745048
9	MP0003011_delayed_dark_adaptation	2.01897748
10	MP0002822_catalepsy	11.9777514
11	MP0005084_abnormal_gallbladder_morpholo	1.88329794
12	MP0002282_abnormal_trachea_morphology	1.80334000
13	MP0002249_abnormal_larynx_morphology	1.76363446
14	MP0002938_white_spotting	1.71573254
15	MP0002736_abnormal_nociception_after	1.69955285
16	MP0001905_abnormal_dopamine_level	1.69409486
17	MP0000372_irregular_coat_pigmentation	1.62632368
18	MP0005171_absent_coat_pigmentation	1.62391353
19	MP0002735_abnormal_chemical_nociception	1.54502833
20	MP0002102_abnormal_ear_morphology	1.49115782
21	MP0010030_abnormal_orbit_morphology	1.43860435
22	MP0001293_anophthalmia	1.43677947
23	MP0008872_abnormal_physiological_respon	1.41391888
24	MP0004145_abnormal_muscle_electrophysio	1.39931519
25	MP0004147_increased_porphyrin_level	1.38760366
26	MP0006138_congestive_heart_failure	1.34204888
27	MP0003283_abnormal_digestive_organ	1.33196204
28	MP0002277_abnormal_respiratory_mucosa	1.30318940
29	MP0003868_abnormal_feces_composition	1.29015888
30	MP0009745_abnormal_behavioral_response	1.23812865
31	MP0001968_abnormal_touch/_nociception	1.22798382
32	MP0009053_abnormal_anal_canal	1.16982103
33	MP0008789_abnormal_olfactory_epithelium	1.13388595
34	MP0001970_abnormal_pain_threshold	1.11008138
35	MP0003959_abnormal_lean_body	1.09594659
36	MP0004133_heterotaxia	1.07260602
37	MP0008058_abnormal_DNA_repair	1.05144995
38	MP0002095_abnormal_skin_pigmentation	1.04315903
39	MP0005394_taste/olfaction_phenotype	1.02785124
40	MP0005499_abnormal_olfactory_system	1.02785124
41	MP0001984_abnormal_olfaction	1.02616085
42	MP0005551_abnormal_eye_electrophysiolog	1.01035415
43	MP0006072_abnormal_retinal_apoptosis	1.00675987
44	MP0009780_abnormal_chondrocyte_physiolo	0.96522194
45	MP0003119_abnormal_digestive_system	0.94819329
46	MP0003646_muscle_fatigue	0.93848827
47	MP0002233_abnormal_nose_morphology	0.93841977
48	MP0003890_abnormal_embryonic-extraembry	0.93392352
49	MP0001486_abnormal_startle_reflex	0.91961799
50	MP0000383_abnormal_hair_follicle	0.91788971
51	MP0001324_abnormal_eye_pigmentation	0.90230528
52	MP0006035_abnormal_mitochondrial_morpho	0.89411893
53	MP0001986_abnormal_taste_sensitivity	0.87473677
54	MP0005253_abnormal_eye_physiology	0.87138337
55	MP0002876_abnormal_thyroid_physiology	0.86758450
56	MP0001177_atelectasis	0.86515814
57	MP0001485_abnormal_pinna_reflex	0.86448757
58	MP0000026_abnormal_inner_ear	0.85850499
59	MP0000631_abnormal_neuroendocrine_gland	0.85371778
60	MP0004924_abnormal_behavior	0.85341828
61	MP0005386_behavior/neurological_phenoty	0.85341828
62	MP0002928_abnormal_bile_duct	0.84839712
63	MP0003938_abnormal_ear_development	0.84247746
64	MP0006276_abnormal_autonomic_nervous	0.82166964
65	MP0005408_hypopigmentation	0.81914363
66	MP0000371_diluted_coat_color	0.81646517
67	MP0004885_abnormal_endolymph	0.81467131
68	MP0001286_abnormal_eye_development	0.81251166
69	MP0003806_abnormal_nucleotide_metabolis	0.81073754
70	MP0003195_calcinosis	0.78500994
71	MP0005620_abnormal_muscle_contractility	0.77803266
72	MP0005174_abnormal_tail_pigmentation	0.77334549
73	MP0002932_abnormal_joint_morphology	0.77211902
74	MP0003942_abnormal_urinary_system	0.71514229
75	MP0005423_abnormal_somatic_nervous	0.69817920
76	MP0002572_abnormal_emotion/affect_behav	0.69620348
77	MP0003755_abnormal_palate_morphology	0.68840695
78	MP0005448_abnormal_energy_balance	0.68414079
79	MP0002734_abnormal_mechanical_nocicepti	0.68262738
80	MP0002733_abnormal_thermal_nociception	0.67337974
81	MP0001501_abnormal_sleep_pattern	0.66802174
82	MP0003567_abnormal_fetal_cardiomyocyte	0.66149881
83	MP0000778_abnormal_nervous_system	0.65440905
84	MP0004742_abnormal_vestibular_system	0.65181900
85	MP0000534_abnormal_ureter_morphology	0.64923163
86	MP0000579_abnormal_nail_morphology	0.64548675
87	MP0005385_cardiovascular_system_phenoty	0.63675880
88	MP0001544_abnormal_cardiovascular_syste	0.63675880
89	MP0005330_cardiomyopathy	0.63046480
90	MP0005391_vision/eye_phenotype	0.62750339
91	MP0002067_abnormal_sensory_capabilities	0.62442888
92	MP0000538_abnormal_urinary_bladder	0.59612789
93	MP0002638_abnormal_pupillary_reflex	0.59136701
94	MP0002557_abnormal_social/conspecific_i	0.58537960
95	MP0002272_abnormal_nervous_system	0.58021030
96	MP0002064_seizures	0.57766891
97	MP0001873_stomach_inflammation	0.57447621
98	MP0004142_abnormal_muscle_tone	0.57447266
99	MP0001664_abnormal_digestion	0.57217822
100	MP0003115_abnormal_respiratory_system	0.56250054

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	5.28853630
2	Birth length less than 3rd percentile (HP:0003561)	4.53423849
3	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.26100335
4	Poor head control (HP:0002421)	4.06016797
5	Septo-optic dysplasia (HP:0100842)	3.87422234
6	Congenital stationary night blindness (HP:0007642)	3.72943815
7	Maternal diabetes (HP:0009800)	3.46780878
8	Abolished electroretinogram (ERG) (HP:0000550)	3.36472501
9	Testicular atrophy (HP:0000029)	3.33365929
10	Macrocytic anemia (HP:0001972)	3.31492072
11	Constricted visual fields (HP:0001133)	3.25293173
12	Dyschromatopsia (HP:0007641)	3.24921322
13	Abnormal number of erythroid precursors (HP:0012131)	3.14167434
14	Abnormality of cells of the erythroid lineage (HP:0012130)	3.12325216
15	True hermaphroditism (HP:0010459)	3.05891377
16	Pigmentary retinal degeneration (HP:0001146)	2.96287922
17	Reticulocytopenia (HP:0001896)	2.93284104
18	Congenital sensorineural hearing impairment (HP:0008527)	2.92540471
19	Central scotoma (HP:0000603)	2.88925437
20	Chorioretinal atrophy (HP:0000533)	2.88595736
21	Hemiparesis (HP:0001269)	2.87986747
22	Rhinitis (HP:0012384)	2.78779851
23	Colon cancer (HP:0003003)	2.78195661
24	Follicular hyperkeratosis (HP:0007502)	2.64452469
25	Chronic bronchitis (HP:0004469)	2.62811886
26	Hyperglycinuria (HP:0003108)	2.53871963
27	Medial flaring of the eyebrow (HP:0010747)	2.51220540
28	Progressive inability to walk (HP:0002505)	2.51102518
29	Pancreatic cysts (HP:0001737)	2.50434666
30	Acute necrotizing encephalopathy (HP:0006965)	2.48605881
31	Congenital primary aphakia (HP:0007707)	2.45976280
32	Abnormal respiratory motile cilium physiology (HP:0012261)	2.44732578
33	Esophageal atresia (HP:0002032)	2.41299714
34	Bronchomalacia (HP:0002780)	2.38104857
35	11 pairs of ribs (HP:0000878)	2.37932141
36	Optic disc pallor (HP:0000543)	2.37699952
37	Tubulointerstitial fibrosis (HP:0005576)	2.36879355
38	Gait imbalance (HP:0002141)	2.36271432
39	Acute encephalopathy (HP:0006846)	2.33232556
40	Concave nail (HP:0001598)	2.31317749
41	Vaginal atresia (HP:0000148)	2.30328663
42	Opisthotonus (HP:0002179)	2.28537723
43	Nasolacrimal duct obstruction (HP:0000579)	2.26218019
44	Absent septum pellucidum (HP:0001331)	2.25085328
45	Lipid accumulation in hepatocytes (HP:0006561)	2.22622554
46	Genital tract atresia (HP:0001827)	2.17887996
47	Large for gestational age (HP:0001520)	2.17048248
48	Decreased circulating renin level (HP:0003351)	2.16278069
49	Progressive cerebellar ataxia (HP:0002073)	2.15462624
50	Abnormal mitochondria in muscle tissue (HP:0008316)	2.15065422
51	Carpal bone hypoplasia (HP:0001498)	2.12686760
52	Mitochondrial inheritance (HP:0001427)	2.12232735
53	Stenosis of the external auditory canal (HP:0000402)	2.10644020
54	Tracheomalacia (HP:0002779)	2.09754722
55	Woolly hair (HP:0002224)	2.07817333
56	Bilateral microphthalmos (HP:0007633)	2.06094348
57	Hyperglycinemia (HP:0002154)	2.05020368
58	Cortical dysplasia (HP:0002539)	2.04010403
59	Neonatal short-limb short stature (HP:0008921)	2.04002438
60	Abnormality of cochlea (HP:0000375)	2.03514022
61	Abnormality of the lacrimal duct (HP:0011481)	2.03002112
62	Attenuation of retinal blood vessels (HP:0007843)	2.01831898
63	Anophthalmia (HP:0000528)	2.00882475
64	Abnormality of the diencephalon (HP:0010662)	2.00084794
65	Missing ribs (HP:0000921)	1.96882472
66	Nephrogenic diabetes insipidus (HP:0009806)	1.91940302
67	Bony spicule pigmentary retinopathy (HP:0007737)	1.91475427
68	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.90353901
69	Abnormality of the nasolacrimal system (HP:0000614)	1.89414247
70	Abnormality of glycine metabolism (HP:0010895)	1.89242932
71	Abnormality of serine family amino acid metabolism (HP:0010894)	1.89242932
72	Pallor (HP:0000980)	1.86711388
73	Breast hypoplasia (HP:0003187)	1.85699892
74	Abnormality of the labia minora (HP:0012880)	1.85625337
75	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.82997917
76	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.81810487
77	Polydipsia (HP:0001959)	1.81765468
78	Abnormal drinking behavior (HP:0030082)	1.81765468
79	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.81481305
80	Pancreatic fibrosis (HP:0100732)	1.80828204
81	Hepatocellular necrosis (HP:0001404)	1.80594366
82	Inability to walk (HP:0002540)	1.75662689
83	Progressive macrocephaly (HP:0004481)	1.75289733
84	Type II lissencephaly (HP:0007260)	1.75212302
85	Respiratory distress (HP:0002098)	1.75153830
86	Abnormality of the septum pellucidum (HP:0007375)	1.74841420
87	Abnormality of chromosome segregation (HP:0002916)	1.73974383
88	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.73847333
89	Chronic hepatic failure (HP:0100626)	1.73247638
90	Anencephaly (HP:0002323)	1.72865597
91	Patchy hypopigmentation of hair (HP:0011365)	1.69737597
92	Megaloblastic anemia (HP:0001889)	1.69601653
93	Bronchiectasis (HP:0002110)	1.69262106
94	Synostosis involving the elbow (HP:0003938)	1.68585244
95	Humeroradial synostosis (HP:0003041)	1.68585244
96	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.67424532
97	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.67424532
98	Increased CSF lactate (HP:0002490)	1.65896215
99	Abnormality of midbrain morphology (HP:0002418)	1.65528218
100	Molar tooth sign on MRI (HP:0002419)	1.65528218

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	5.18889468
2	PNCK	3.36365244
3	TAOK3	3.15016581
4	WEE1	2.95924753
5	NEK1	2.42022971
6	PASK	2.41731860
7	VRK2	2.35124250
8	CDC7	2.24351250
9	WNK3	2.11589411
10	VRK1	2.08780865
11	PIK3CA	2.03964863
12	NUAK1	2.02679571
13	TLK1	2.00891110
14	TRPM7	1.92514932
15	STK16	1.92093240
16	DYRK3	1.82844794
17	SIK1	1.78335260
18	MAP3K10	1.75657421
19	TGFBR1	1.72680613
20	FRK	1.71295102
21	TSSK6	1.69277208
22	MAPKAPK5	1.65360885
23	ADRBK2	1.63204121
24	STK24	1.59876503
25	EIF2AK3	1.53570146
26	EPHB2	1.46352674
27	WNK4	1.46092996
28	NEK2	1.42153673
29	DYRK1B	1.38933605
30	BCKDK	1.38711080
31	DAPK2	1.34026014
32	CDK3	1.23744384
33	DYRK2	1.23492693
34	MELK	1.22331297
35	PLK3	1.21786826
36	STK38L	1.19950050
37	TAF1	1.14582041
38	ADRBK1	1.13719067
39	BMPR1B	1.13030349
40	ZAK	1.10147042
41	FGFR1	1.06393419
42	MAP3K7	1.06379256
43	MAP4K2	1.05909750
44	MAPK13	0.96629852
45	BLK	0.96028893
46	PKN1	0.86644503
47	GRK1	0.86370751
48	DAPK3	0.83851584
49	TNIK	0.81540491
50	PDK2	0.79850096
51	MAP2K2	0.76976658
52	EIF2AK2	0.74612146
53	GRK5	0.73803283
54	PLK2	0.73670453
55	EPHA4	0.72270816
56	STK3	0.71785075
57	SRPK1	0.71602786
58	PLK4	0.70957302
59	LRRK2	0.70890143
60	PRKCG	0.70421873
61	PINK1	0.68542698
62	OXSR1	0.65961629
63	ATR	0.64901790
64	NEK6	0.61470159
65	MARK3	0.60952032
66	MINK1	0.60401044
67	AURKA	0.59936499
68	ACVR1B	0.58191712
69	CHEK2	0.57677020
70	PRKCE	0.55757290
71	TAOK1	0.55089102
72	BUB1	0.52416689
73	PLK1	0.51871067
74	CSNK1G1	0.48977745
75	INSRR	0.48817238
76	CDK8	0.48734640
77	CSF1R	0.48664627
78	CSNK1A1	0.48644156
79	TEC	0.42682302
80	TTK	0.41859714
81	STK39	0.41450499
82	STK11	0.40837928
83	MKNK1	0.40541787
84	PTK6	0.38260916
85	OBSCN	0.37353836
86	PRKCI	0.36380286
87	PAK2	0.35830149
88	DDR2	0.34661441
89	AURKB	0.32742130
90	PRKACB	0.31544674
91	PRKACA	0.30591698
92	ERBB3	0.30248305
93	DYRK1A	0.30096107
94	BRSK1	0.28325112
95	BRSK2	0.28277414
96	PRKDC	0.27207170
97	MAP3K6	0.26356487
98	NTRK2	0.26016430
99	CDK7	0.25818657
100	CSNK2A1	0.25110717

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.04808069
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	4.90407505
3	Protein export_Homo sapiens_hsa03060	2.78219263
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.73487467
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.39758843
6	Homologous recombination_Homo sapiens_hsa03440	2.38068563
7	Parkinsons disease_Homo sapiens_hsa05012	2.27412300
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.13125033
9	Propanoate metabolism_Homo sapiens_hsa00640	2.01861240
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.84877902
11	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.84371838
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.79713770
13	Phototransduction_Homo sapiens_hsa04744	1.75597594
14	Nucleotide excision repair_Homo sapiens_hsa03420	1.71595439
15	Caffeine metabolism_Homo sapiens_hsa00232	1.67141551
16	Butanoate metabolism_Homo sapiens_hsa00650	1.65954228
17	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.63790977
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.62114897
19	Alzheimers disease_Homo sapiens_hsa05010	1.59423049
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.55679808
21	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.53148511
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.52660752
23	One carbon pool by folate_Homo sapiens_hsa00670	1.43784333
24	Huntingtons disease_Homo sapiens_hsa05016	1.42648356
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.39852325
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.38502649
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.38298846
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.35290234
29	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.30141030
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.23832442
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.20893736
32	Non-homologous end-joining_Homo sapiens_hsa03450	1.19581892
33	DNA replication_Homo sapiens_hsa03030	1.19460842
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.19391983
35	Steroid biosynthesis_Homo sapiens_hsa00100	1.16189697
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.12458832
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.12356196
38	Nicotine addiction_Homo sapiens_hsa05033	1.11818186
39	RNA polymerase_Homo sapiens_hsa03020	1.10330123
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.08960939
41	Peroxisome_Homo sapiens_hsa04146	1.05915314
42	Nitrogen metabolism_Homo sapiens_hsa00910	1.04946063
43	beta-Alanine metabolism_Homo sapiens_hsa00410	1.04774083
44	Fatty acid elongation_Homo sapiens_hsa00062	1.04366358
45	Mismatch repair_Homo sapiens_hsa03430	1.02502672
46	Proteasome_Homo sapiens_hsa03050	1.02436903
47	Basal cell carcinoma_Homo sapiens_hsa05217	0.95508649
48	Glycerolipid metabolism_Homo sapiens_hsa00561	0.94084130
49	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.92030626
50	Base excision repair_Homo sapiens_hsa03410	0.81800595
51	Olfactory transduction_Homo sapiens_hsa04740	0.78959373
52	Folate biosynthesis_Homo sapiens_hsa00790	0.78934649
53	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.76263202
54	Fat digestion and absorption_Homo sapiens_hsa04975	0.75805621
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75441139
56	Fanconi anemia pathway_Homo sapiens_hsa03460	0.74790804
57	Fatty acid degradation_Homo sapiens_hsa00071	0.74490398
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73451825
59	RNA degradation_Homo sapiens_hsa03018	0.72262548
60	Long-term depression_Homo sapiens_hsa04730	0.68554405
61	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.67408794
62	Cholinergic synapse_Homo sapiens_hsa04725	0.66703552
63	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.65835892
64	Retinol metabolism_Homo sapiens_hsa00830	0.65608237
65	Axon guidance_Homo sapiens_hsa04360	0.65328706
66	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.64691140
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64103183
68	Metabolic pathways_Homo sapiens_hsa01100	0.61985455
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60238273
70	Circadian entrainment_Homo sapiens_hsa04713	0.58329003
71	Bile secretion_Homo sapiens_hsa04976	0.58244110
72	Basal transcription factors_Homo sapiens_hsa03022	0.57954269
73	Histidine metabolism_Homo sapiens_hsa00340	0.57539111
74	Glutamatergic synapse_Homo sapiens_hsa04724	0.56524109
75	Morphine addiction_Homo sapiens_hsa05032	0.53482734
76	Serotonergic synapse_Homo sapiens_hsa04726	0.53468884
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51932174
78	ABC transporters_Homo sapiens_hsa02010	0.51385652
79	Sulfur relay system_Homo sapiens_hsa04122	0.51211474
80	Fatty acid metabolism_Homo sapiens_hsa01212	0.51076893
81	Cell cycle_Homo sapiens_hsa04110	0.49718788
82	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.47404461
83	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.46792715
84	Pyrimidine metabolism_Homo sapiens_hsa00240	0.46774820
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.46710927
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45665436
87	Spliceosome_Homo sapiens_hsa03040	0.42975191
88	Purine metabolism_Homo sapiens_hsa00230	0.42019048
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41978803
90	Taste transduction_Homo sapiens_hsa04742	0.40843023
91	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.40731142
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40575721
93	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39545749
94	Mineral absorption_Homo sapiens_hsa04978	0.33437558
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.33102788
96	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.32734771
97	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.32201997
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.27634272
99	Lysine degradation_Homo sapiens_hsa00310	0.27089695
100	Insulin secretion_Homo sapiens_hsa04911	0.25184781

MRE11B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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