MREG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)6.21650798
2regulation of vitamin D biosynthetic process (GO:0060556)5.42877850
3imidazole-containing compound metabolic process (GO:0052803)5.18288001
4oligosaccharide catabolic process (GO:0009313)5.12046615
5regulation of dendritic cell antigen processing and presentation (GO:0002604)5.11509230
6glycosphingolipid catabolic process (GO:0046479)4.94753652
7positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.57682292
8glycolipid catabolic process (GO:0019377)4.36933150
9negative regulation of interleukin-12 production (GO:0032695)4.34917032
10interferon-gamma secretion (GO:0072643)4.23069912
11regulation of fever generation (GO:0031620)4.22286890
12regulation of posttranscriptional gene silencing (GO:0060147)4.18385256
13regulation of gene silencing by miRNA (GO:0060964)4.18385256
14regulation of gene silencing by RNA (GO:0060966)4.18385256
15positive regulation of heat generation (GO:0031652)4.08957810
16amino sugar catabolic process (GO:0046348)4.08294269
17ceramide catabolic process (GO:0046514)4.00730243
18regulation of vitamin metabolic process (GO:0030656)3.97996020
19regulation of cholesterol storage (GO:0010885)3.95111636
20positive regulation of keratinocyte differentiation (GO:0045618)3.90090293
21response to peptidoglycan (GO:0032494)3.90031131
22negative regulation of fatty acid biosynthetic process (GO:0045717)3.88727367
23folic acid-containing compound biosynthetic process (GO:0009396)3.86117152
24T-helper 1 type immune response (GO:0042088)3.84057878
25glycine metabolic process (GO:0006544)3.82637975
26regulation of RIG-I signaling pathway (GO:0039535)3.77413621
27osteoclast differentiation (GO:0030316)3.73274599
28positive regulation of osteoclast differentiation (GO:0045672)3.73240686
29regulation of interferon-alpha production (GO:0032647)3.69630661
30regulation of mononuclear cell migration (GO:0071675)3.69500147
31regulation of podosome assembly (GO:0071801)3.69290047
32serine family amino acid catabolic process (GO:0009071)3.69110908
33lipopolysaccharide-mediated signaling pathway (GO:0031663)3.67426130
34cellular response to thyroid hormone stimulus (GO:0097067)3.66734290
35positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.66405540
36positive regulation of antigen processing and presentation (GO:0002579)3.63049717
37membrane lipid catabolic process (GO:0046466)3.60198377
38regulation of helicase activity (GO:0051095)3.54258030
39regulation of chronic inflammatory response (GO:0002676)3.53581759
40nuclear pore organization (GO:0006999)3.51868149
41eosinophil chemotaxis (GO:0048245)3.51092633
42regulation of cytokine secretion involved in immune response (GO:0002739)3.47003160
43antigen processing and presentation of endogenous antigen (GO:0019883)3.45339027
44monocyte chemotaxis (GO:0002548)3.42859489
45positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.42029642
46positive regulation of bone remodeling (GO:0046852)3.40739662
47positive regulation of bone resorption (GO:0045780)3.40739662
48sphingolipid catabolic process (GO:0030149)3.40421697
49urea metabolic process (GO:0019627)3.36610837
50urea cycle (GO:0000050)3.36610837
51natural killer cell mediated immunity (GO:0002228)3.36114233
52natural killer cell mediated cytotoxicity (GO:0042267)3.36114233
53nuclear pore complex assembly (GO:0051292)3.34737543
54immunoglobulin mediated immune response (GO:0016064)3.31283460
55sphingosine metabolic process (GO:0006670)3.31220952
56kynurenine metabolic process (GO:0070189)3.30540718
57positive regulation of chemokine biosynthetic process (GO:0045080)3.28015671
58positive regulation of tissue remodeling (GO:0034105)3.26532970
59regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.26468887
60tetrahydrofolate metabolic process (GO:0046653)3.23548966
61positive regulation of type 2 immune response (GO:0002830)3.23315015
62negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.21582329
63branching involved in labyrinthine layer morphogenesis (GO:0060670)3.16157810
64regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.15652755
65erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.14904069
66L-phenylalanine metabolic process (GO:0006558)3.14904069
67regulation of T-helper 1 cell differentiation (GO:0045625)3.14445186
68tryptophan catabolic process (GO:0006569)3.13642651
69indole-containing compound catabolic process (GO:0042436)3.13642651
70indolalkylamine catabolic process (GO:0046218)3.13642651
71positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.13287690
72positive regulation of monocyte chemotaxis (GO:0090026)3.13284112
73positive regulation of interferon-alpha production (GO:0032727)3.13246562
74nitrogen cycle metabolic process (GO:0071941)3.10969952
75myeloid dendritic cell differentiation (GO:0043011)3.10385260
76aromatic amino acid family catabolic process (GO:0009074)3.10305007
77negative regulation of nitric oxide biosynthetic process (GO:0045019)3.08506493
78interferon-gamma-mediated signaling pathway (GO:0060333)3.06695364
79regulation of heat generation (GO:0031650)3.05520969
80diol metabolic process (GO:0034311)3.05062760
81positive regulation of NF-kappaB import into nucleus (GO:0042346)3.03946975
82eosinophil migration (GO:0072677)3.03925514
83erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.02829943
84L-phenylalanine catabolic process (GO:0006559)3.02829943
85positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.01952733
86tryptophan metabolic process (GO:0006568)3.01819090
87serine family amino acid metabolic process (GO:0009069)3.01526847
88regulation of antigen processing and presentation (GO:0002577)3.01420653
89regulation of protein polyubiquitination (GO:1902914)3.01148611
90intracellular pH reduction (GO:0051452)2.99971906
91positive regulation of protein oligomerization (GO:0032461)2.99606680
92positive regulation of protein homooligomerization (GO:0032464)2.99554184
93positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.98569486
94positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.96374391
95N-acetylneuraminate metabolic process (GO:0006054)2.93452499
96regulation of interleukin-12 production (GO:0032655)2.93023952
97sulfur amino acid catabolic process (GO:0000098)2.92002652
98regulation of prostaglandin secretion (GO:0032306)2.88477452
99regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.88388317
100negative regulation of lipid storage (GO:0010888)2.87347475
101response to protozoan (GO:0001562)2.87073818
102fat-soluble vitamin biosynthetic process (GO:0042362)2.86992922
103epithelial cell differentiation involved in prostate gland development (GO:0060742)2.84774746
104type I interferon signaling pathway (GO:0060337)2.83990010
105cellular response to type I interferon (GO:0071357)2.83990010
106macrophage activation involved in immune response (GO:0002281)2.83453902
107pH reduction (GO:0045851)2.81829151
108positive regulation of prostaglandin secretion (GO:0032308)2.81102954
109decidualization (GO:0046697)2.80578261
110regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.79871756
111negative regulation of myeloid cell apoptotic process (GO:0033033)2.79402852
112regulation of interferon-gamma biosynthetic process (GO:0045072)2.79164333
113response to type I interferon (GO:0034340)2.79115018
114homocysteine metabolic process (GO:0050667)2.79102260
115regulation of immunoglobulin secretion (GO:0051023)2.77611724
116regulation of membrane protein ectodomain proteolysis (GO:0051043)2.77021741
117positive regulation of cell size (GO:0045793)2.76815805
118determination of adult lifespan (GO:0008340)2.76334604
119phospholipid efflux (GO:0033700)2.75555467
120cysteine metabolic process (GO:0006534)2.75296976
121glyoxylate metabolic process (GO:0046487)2.74675088
122folic acid metabolic process (GO:0046655)2.74593739
123regulation of NF-kappaB import into nucleus (GO:0042345)2.73803617
124regulation of inflammatory response to antigenic stimulus (GO:0002861)2.73763100
125regulation of nitric oxide biosynthetic process (GO:0045428)2.73231215
126high-density lipoprotein particle remodeling (GO:0034375)2.72194370
127regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.70582821
128regulation of T-helper cell differentiation (GO:0045622)2.70224819
129cellular response to lipopolysaccharide (GO:0071222)2.70156343
130response to thyroid hormone (GO:0097066)2.69942876
131negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.68609342
132intestinal epithelial cell development (GO:0060576)2.68579906
133B cell mediated immunity (GO:0019724)2.68486891
134cytokine secretion (GO:0050663)2.68133017
135virion attachment to host cell (GO:0019062)2.68041820
136adhesion of symbiont to host cell (GO:0044650)2.68041820
137regulation of response to interferon-gamma (GO:0060330)2.66979349
138positive regulation of cholesterol efflux (GO:0010875)2.66396590
139glucosamine-containing compound catabolic process (GO:1901072)2.64768881
140growth hormone receptor signaling pathway (GO:0060396)2.64249628
141regulation of chemokine biosynthetic process (GO:0045073)2.63899373
142dendritic cell differentiation (GO:0097028)2.63347305
143serine family amino acid biosynthetic process (GO:0009070)2.62939998
144phospholipid homeostasis (GO:0055091)2.61222680
145positive regulation of cholesterol transport (GO:0032376)2.60884079
146positive regulation of sterol transport (GO:0032373)2.60884079
147regulation of histone H3-K9 methylation (GO:0051570)2.60622973
148regulation of hypersensitivity (GO:0002883)2.58914248
149folic acid-containing compound metabolic process (GO:0006760)2.55875439
150positive regulation of protein import into nucleus, translocation (GO:0033160)2.55532156
151regulation of cholesterol esterification (GO:0010872)2.54429618
152fatty acid homeostasis (GO:0055089)2.52129143
153regulation of integrin activation (GO:0033623)2.52094730
154bile acid biosynthetic process (GO:0006699)2.51717657
155triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.50460788
156anterior/posterior axis specification, embryo (GO:0008595)2.49974199
157mitotic nuclear envelope disassembly (GO:0007077)2.49851136
158one-carbon metabolic process (GO:0006730)2.49211412
159negative regulation of fatty acid metabolic process (GO:0045922)2.48941144
160protein K6-linked ubiquitination (GO:0085020)2.48791882
161purine nucleobase biosynthetic process (GO:0009113)2.48626915
162regulation of cholesterol homeostasis (GO:2000188)2.48296096
163regulation of MHC class I biosynthetic process (GO:0045343)2.47222366
164histone H2A monoubiquitination (GO:0035518)2.46384533
165positive regulation of SMAD protein import into nucleus (GO:0060391)2.45622144
166aromatic amino acid family metabolic process (GO:0009072)2.45294323
167alpha-amino acid catabolic process (GO:1901606)2.45276719
168somatic diversification of immune receptors via somatic mutation (GO:0002566)2.44593697
169somatic hypermutation of immunoglobulin genes (GO:0016446)2.44593697
170nucleobase biosynthetic process (GO:0046112)2.44511721
171regulation of bile acid biosynthetic process (GO:0070857)2.44429271
172regulation of gene silencing (GO:0060968)2.43881274
173myeloid dendritic cell activation (GO:0001773)2.42846131
174formation of translation preinitiation complex (GO:0001731)2.42287489
175dicarboxylic acid biosynthetic process (GO:0043650)2.41701149
176cellular response to glucose starvation (GO:0042149)2.41426435
177positive regulation of interleukin-12 production (GO:0032735)2.41049034
178alkaloid metabolic process (GO:0009820)2.40840889
179pore complex assembly (GO:0046931)2.40667006
180protein carboxylation (GO:0018214)2.40110062
181peptidyl-glutamic acid carboxylation (GO:0017187)2.40110062
182negative regulation of histone methylation (GO:0031061)2.38003228
183mitotic metaphase plate congression (GO:0007080)2.35378709
184pteridine-containing compound biosynthetic process (GO:0042559)2.34821820
185positive regulation of T-helper cell differentiation (GO:0045624)2.34549809
186negative regulation of fibrinolysis (GO:0051918)2.33809254
187positive regulation of Cdc42 GTPase activity (GO:0043089)2.32963805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.17236532
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.76244001
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.69334136
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.66837454
5GATA1_22025678_ChIP-Seq_K562_Human3.14688423
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.13930334
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.13930334
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.13930334
9* ESR1_21235772_ChIP-Seq_MCF-7_Human3.06518214
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05305581
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.03908360
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.97921741
13* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.85355089
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.83480165
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.82822667
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.73152769
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.69822463
18* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.67474544
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.64818557
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.62359628
21* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.61872848
22STAT3_1855785_ChIP-Seq_MESCs_Mouse2.52572825
23* ESR2_21235772_ChIP-Seq_MCF-7_Human2.49117053
24* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.44398047
25* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.37003144
26IRF8_22096565_ChIP-ChIP_GC-B_Human2.33887974
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.28314305
28* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.25568361
29TCF3_18692474_ChIP-Seq_MEFs_Mouse2.25209045
30NOTCH1_21737748_ChIP-Seq_TLL_Human2.18490328
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.17629702
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.12543396
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.05744656
34MYC_18555785_ChIP-Seq_MESCs_Mouse2.03618047
35* LXR_22158963_ChIP-Seq_LIVER_Mouse2.01629821
36ZNF263_19887448_ChIP-Seq_K562_Human2.01578187
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98917427
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.95980333
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94382311
40TCF3_18692474_ChIP-Seq_MESCs_Mouse1.88969639
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88823613
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.87059865
43PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.86143194
44* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86116631
45SPI1_23547873_ChIP-Seq_NB4_Human1.83865769
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.79257445
47SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.74005279
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72238112
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71907512
50* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.69770451
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69282458
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67848710
53* VDR_24787735_ChIP-Seq_THP-1_Human1.67393934
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.66908209
55* PU_27001747_Chip-Seq_BMDM_Mouse1.63607762
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62565908
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56363732
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.55450950
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55200705
60* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54428622
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54113959
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52492103
63* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51047334
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50900226
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50414729
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.49477978
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47757624
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46654338
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46194486
70ELF5_23300383_ChIP-Seq_T47D_Human1.42255670
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.41359126
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40839801
73NANOG_18692474_ChIP-Seq_MEFs_Mouse1.40356918
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38262399
75SOX2_18692474_ChIP-Seq_MEFs_Mouse1.37265375
76* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37017008
77* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.35770102
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34646392
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32780920
80KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31840238
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31334569
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29748767
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29370667
84* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28198410
85POU5F1_16518401_ChIP-PET_MESCs_Mouse1.27314059
86NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.26734745
87NANOG_18692474_ChIP-Seq_MESCs_Mouse1.26255482
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25409932
89* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25324147
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23578486
91OCT4_18692474_ChIP-Seq_MEFs_Mouse1.22382184
92SOX2_18692474_ChIP-Seq_MESCs_Mouse1.22355199
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21189723
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17278842
95ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15839228
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15719959
97GATA3_24758297_ChIP-Seq_MCF-7_Human1.14300456
98* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13268292
99MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12805217
100* KAP1_27257070_Chip-Seq_ESCs_Mouse1.12375509
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10673751
102TFEB_21752829_ChIP-Seq_HELA_Human1.10416286
103* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10060305
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09795708
105VDR_24763502_ChIP-Seq_THP-1_Human1.09403357
106KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08883807
107CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07100858
108CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06668622
109CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06246047
110RUNX1_27514584_Chip-Seq_MCF-7_Human1.03863702
111ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03570951
112STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03100601
113NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02469587
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02266866
115AR_21909140_ChIP-Seq_LNCAP_Human1.01247711
116E2F1_21310950_ChIP-Seq_MCF-7_Human1.00741342
117PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00167772
118MYC_22102868_ChIP-Seq_BL_Human0.99844562
119POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.99592341
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99330118
121* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99140495
122JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98362926
123RUNX1_22412390_ChIP-Seq_EML_Mouse0.98030365
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97618603
125MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97600509
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97371947
127NANOG_16518401_ChIP-PET_MESCs_Mouse0.96719135
128STAT1_20625510_ChIP-Seq_HELA_Human0.95873898
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94856430
130SPI1_23127762_ChIP-Seq_K562_Human0.94408764
131* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92634485
132SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92387043
133SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92387043
134XRN2_22483619_ChIP-Seq_HELA_Human0.91267603
135MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90828649
136CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90607071
137DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89188700
138RACK7_27058665_Chip-Seq_MCF-7_Human0.88547508
139DCP1A_22483619_ChIP-Seq_HELA_Human0.85983085
140VDR_21846776_ChIP-Seq_THP-1_Human0.85885726
141CLOCK_20551151_ChIP-Seq_293T_Human0.85504231
142MAF_26560356_Chip-Seq_TH1_Human0.85239979
143SOX2_20726797_ChIP-Seq_SW620_Human0.84875221
144NANOG_21062744_ChIP-ChIP_HESCs_Human0.84833187
145STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83866279
146TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83843964
147* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83222711
148EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83066926
149* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82231614
150SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82127550
151KDM5A_27292631_Chip-Seq_BREAST_Human0.82066343
152TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82061677
153HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80170077
154* GATA3_26560356_Chip-Seq_TH2_Human0.80121848
155KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79368082
156* GATA6_25053715_ChIP-Seq_YYC3_Human0.79360884
157SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77226132
158ATF3_27146783_Chip-Seq_COLON_Human0.77206824
159PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.77143219
160TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76673325
161GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76632259
162VDR_23849224_ChIP-Seq_CD4+_Human0.76529980
163* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.76395320
164GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75763685
165* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.73944547
166HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.72159242
167TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.71785808
168RXRA_24833708_ChIP-Seq_LIVER_Mouse0.71069999
169SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70736961

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.14739279
2MP0003806_abnormal_nucleotide_metabolis4.05623172
3MP0002138_abnormal_hepatobiliary_system3.87860654
4MP0003303_peritoneal_inflammation3.84499391
5MP0005058_abnormal_lysosome_morphology3.68103048
6MP0001348_abnormal_lacrimal_gland3.17797327
7MP0008057_abnormal_DNA_replication3.10934889
8MP0002139_abnormal_hepatobiliary_system2.94700755
9MP0001346_abnormal_lacrimal_gland2.81593579
10MP0005085_abnormal_gallbladder_physiolo2.74917857
11MP0000604_amyloidosis2.64477920
12MP0010352_gastrointestinal_tract_polyps2.63697880
13MP0001835_abnormal_antigen_presentation2.46242346
14MP0000685_abnormal_immune_system2.45286466
15MP0005360_urolithiasis2.42035772
16MP0003172_abnormal_lysosome_physiology2.32224939
17MP0005365_abnormal_bile_salt2.26932944
18MP0002419_abnormal_innate_immunity2.16909748
19MP0009840_abnormal_foam_cell2.13728620
20MP0003453_abnormal_keratinocyte_physiol1.94401085
21MP0010234_abnormal_vibrissa_follicle1.92159802
22MP0003075_altered_response_to1.90253611
23MP0003693_abnormal_embryo_hatching1.88861800
24MP0003705_abnormal_hypodermis_morpholog1.88092008
25MP0005310_abnormal_salivary_gland1.84730802
26MP0004510_myositis1.80569971
27MP0005076_abnormal_cell_differentiation1.80331650
28MP0000343_altered_response_to1.79199459
29MP0002009_preneoplasia1.73482133
30MP0003252_abnormal_bile_duct1.71325108
31MP0003724_increased_susceptibility_to1.70022051
32MP0010678_abnormal_skin_adnexa1.68651921
33MP0002796_impaired_skin_barrier1.68143284
34MP0002876_abnormal_thyroid_physiology1.66207504
35MP0005167_abnormal_blood-brain_barrier1.59838903
36MP0004957_abnormal_blastocyst_morpholog1.55745007
37MP0002998_abnormal_bone_remodeling1.54716321
38MP0003329_amyloid_beta_deposits1.54546671
39MP0000383_abnormal_hair_follicle1.53387002
40MP0010094_abnormal_chromosome_stability1.49703083
41MP0005257_abnormal_intraocular_pressure1.48856865
42MP0010307_abnormal_tumor_latency1.48854788
43MP0001845_abnormal_inflammatory_respons1.48267957
44MP0002163_abnormal_gland_morphology1.47001476
45MP0002277_abnormal_respiratory_mucosa1.45983100
46MP0003300_gastrointestinal_ulcer1.45851401
47MP0001533_abnormal_skeleton_physiology1.44136202
48MP0008875_abnormal_xenobiotic_pharmacok1.43446471
49MP0001819_abnormal_immune_cell1.41545432
50MP0009333_abnormal_splenocyte_physiolog1.41398115
51MP0002420_abnormal_adaptive_immunity1.40812939
52MP0003718_maternal_effect1.35740175
53MP0000609_abnormal_liver_physiology1.30240757
54MP0001727_abnormal_embryo_implantation1.30105792
55MP0003077_abnormal_cell_cycle1.29257155
56MP0002166_altered_tumor_susceptibility1.27272809
57MP0003111_abnormal_nucleus_morphology1.25938499
58MP0003941_abnormal_skin_development1.23832884
59MP0002090_abnormal_vision1.22542936
60MP0010155_abnormal_intestine_physiology1.21133766
61MP0004947_skin_inflammation1.20238885
62MP0003690_abnormal_glial_cell1.18778487
63MP0003186_abnormal_redox_activity1.17944894
64MP0002006_tumorigenesis1.17482402
65MP0004381_abnormal_hair_follicle1.17192535
66MP0005387_immune_system_phenotype1.16337155
67MP0001790_abnormal_immune_system1.16337155
68MP0002405_respiratory_system_inflammati1.15365165
69MP0002653_abnormal_ependyma_morphology1.14996928
70MP0009278_abnormal_bone_marrow1.13390114
71MP0003436_decreased_susceptibility_to1.13246476
72MP0001853_heart_inflammation1.13030653
73MP0008058_abnormal_DNA_repair1.11864097
74MP0003195_calcinosis1.11586342
75MP0000350_abnormal_cell_proliferation1.09319945
76MP0004264_abnormal_extraembryonic_tissu1.08347077
77* MP0000371_diluted_coat_color1.07380120
78MP0000516_abnormal_urinary_system1.07267413
79MP0005367_renal/urinary_system_phenotyp1.07267413
80MP0000858_altered_metastatic_potential1.05709262
81MP0003191_abnormal_cellular_cholesterol1.03823036
82MP0003566_abnormal_cell_adhesion1.02533312
83MP0001800_abnormal_humoral_immune1.02387115
84MP0005166_decreased_susceptibility_to1.01216369
85MP0002148_abnormal_hypersensitivity_rea0.99388050
86MP0010329_abnormal_lipoprotein_level0.98612685
87MP0000716_abnormal_immune_system0.98342019
88MP0005266_abnormal_metabolism0.98066672
89MP0004019_abnormal_vitamin_homeostasis0.96682912
90MP0005319_abnormal_enzyme/_coenzyme0.95930504
91MP0005501_abnormal_skin_physiology0.95180637
92MP0001216_abnormal_epidermal_layer0.93691784
93MP0005671_abnormal_response_to0.92906755
94MP0008007_abnormal_cellular_replicative0.92283197
95MP0001764_abnormal_homeostasis0.92084929
96MP0005647_abnormal_sex_gland0.91105829
97MP0000627_abnormal_mammary_gland0.90251473
98MP0001873_stomach_inflammation0.89130991
99MP0005075_abnormal_melanosome_morpholog0.88330757
100MP0001545_abnormal_hematopoietic_system0.87703022
101MP0005397_hematopoietic_system_phenotyp0.87703022
102MP0005408_hypopigmentation0.87584024
103MP0005332_abnormal_amino_acid0.87519426
104MP0003656_abnormal_erythrocyte_physiolo0.87132139
105MP0002332_abnormal_exercise_endurance0.84639674
106MP0000920_abnormal_myelination0.83793120
107MP0005451_abnormal_body_composition0.83372031
108MP0000579_abnormal_nail_morphology0.82945575
109MP0001730_embryonic_growth_arrest0.82186161
110MP0000613_abnormal_salivary_gland0.80007533
111MP0004185_abnormal_adipocyte_glucose0.78368444
112MP0005000_abnormal_immune_tolerance0.77881041
113MP0008260_abnormal_autophagy0.77829293
114MP0003183_abnormal_peptide_metabolism0.77531604
115MP0009785_altered_susceptibility_to0.77242452
116MP0006082_CNS_inflammation0.76719076
117MP0001849_ear_inflammation0.76254329
118MP0000598_abnormal_liver_morphology0.76064799
119MP0005380_embryogenesis_phenotype0.76048714
120MP0001672_abnormal_embryogenesis/_devel0.76048714
121MP0005083_abnormal_biliary_tract0.75175304
122MP0000015_abnormal_ear_pigmentation0.74793253
123MP0005379_endocrine/exocrine_gland_phen0.73680547
124MP0004782_abnormal_surfactant_physiolog0.73656036
125MP0001191_abnormal_skin_condition0.73317088
126MP0002429_abnormal_blood_cell0.72822539
127MP0002086_abnormal_extraembryonic_tissu0.72766139
128MP0004197_abnormal_fetal_growth/weight/0.72080665
129MP0002837_dystrophic_cardiac_calcinosis0.71874364
130MP0003890_abnormal_embryonic-extraembry0.70847206
131MP0004233_abnormal_muscle_weight0.70812198
132MP0009053_abnormal_anal_canal0.70212830
133MP0002452_abnormal_antigen_presenting0.70166633
134MP0005165_increased_susceptibility_to0.69424143
135MP0002398_abnormal_bone_marrow0.69126471
136MP0003448_altered_tumor_morphology0.68370140
137MP0006054_spinal_hemorrhage0.68120515
138MP0005023_abnormal_wound_healing0.67370171
139MP0001881_abnormal_mammary_gland0.67170259
140MP0002019_abnormal_tumor_incidence0.67125181
141MP0002723_abnormal_immune_serum0.66943691
142MP0005025_abnormal_response_to0.66685782
143MP0000689_abnormal_spleen_morphology0.65028374
144MP0009764_decreased_sensitivity_to0.63912131
145MP0000569_abnormal_digit_pigmentation0.63159301
146MP0002118_abnormal_lipid_homeostasis0.63045999
147MP0000377_abnormal_hair_follicle0.62752405
148MP0009765_abnormal_xenobiotic_induced0.62629381
149MP0002098_abnormal_vibrissa_morphology0.62482568
150MP0002088_abnormal_embryonic_growth/wei0.62260974
151MP0003984_embryonic_growth_retardation0.61223187
152MP0008469_abnormal_protein_level0.60734965

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)8.31879837
2Abnormality of liposaccharide metabolism (HP:0010968)8.31879837
3Abnormality of glycosphingolipid metabolism (HP:0004343)8.31879837
4Vacuolated lymphocytes (HP:0001922)6.11505692
5Increased cerebral lipofuscin (HP:0011813)5.78227925
6Increased neuronal autofluorescent lipopigment (HP:0002074)5.06194447
7Intrahepatic cholestasis (HP:0001406)4.84928123
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.62002036
9Disinhibition (HP:0000734)4.49278155
10Loss of speech (HP:0002371)4.04179439
11Dysostosis multiplex (HP:0000943)3.86342527
12Abnormality of macrophages (HP:0004311)3.84701035
13Hypobetalipoproteinemia (HP:0003563)3.72117500
14Autoimmune thrombocytopenia (HP:0001973)3.69186320
15Abnormality of pyrimidine metabolism (HP:0004353)3.59113326
16Hyperglycinuria (HP:0003108)3.58320745
17Mutism (HP:0002300)3.57133391
18Diminished motivation (HP:0000745)3.45414559
19Recurrent bacterial skin infections (HP:0005406)3.45221657
20Apathy (HP:0000741)3.43797467
21Abnormality of aromatic amino acid family metabolism (HP:0004338)3.42826413
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.32491685
23Hyperglycinemia (HP:0002154)3.29625637
24Systemic lupus erythematosus (HP:0002725)3.27434126
25Hypoglycemic coma (HP:0001325)3.26110436
26Recurrent abscess formation (HP:0002722)3.25980836
27Ependymoma (HP:0002888)3.18652707
28J-shaped sella turcica (HP:0002680)3.18156035
29Lip pit (HP:0100267)3.15952675
30Xanthomatosis (HP:0000991)3.12745837
31Epidermoid cyst (HP:0200040)3.12295741
32Neurofibrillary tangles (HP:0002185)3.11875043
33Prolonged partial thromboplastin time (HP:0003645)2.99817353
34Multiple enchondromatosis (HP:0005701)2.99476508
35Hydroxyprolinuria (HP:0003080)2.96373246
36Abnormality of proline metabolism (HP:0010907)2.96373246
37Abnormality of polysaccharide metabolism (HP:0011012)2.95363369
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.95363369
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.95363369
40Esophageal varix (HP:0002040)2.93290508
41Myocardial infarction (HP:0001658)2.88601812
42Deep venous thrombosis (HP:0002625)2.86936294
43Mediastinal lymphadenopathy (HP:0100721)2.86071097
44Abnormality of serine family amino acid metabolism (HP:0010894)2.81878029
45Abnormality of glycine metabolism (HP:0010895)2.81878029
46Urinary glycosaminoglycan excretion (HP:0003541)2.81588475
47Mucopolysacchariduria (HP:0008155)2.81588475
48Cortical dysplasia (HP:0002539)2.80983078
49Hyperammonemia (HP:0001987)2.80909059
50Hypolipoproteinemia (HP:0010981)2.80832784
51Metaphyseal irregularity (HP:0003025)2.79556768
52Hypochromic microcytic anemia (HP:0004840)2.76260166
53Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.70583371
54Inappropriate behavior (HP:0000719)2.61512363
55Abnormality of sulfur amino acid metabolism (HP:0004339)2.55278351
56Hyperinsulinemic hypoglycemia (HP:0000825)2.53759685
57Axonal loss (HP:0003447)2.53280786
58Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.52148816
59Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.50072535
60Right ventricular cardiomyopathy (HP:0011663)2.48441899
61Hyperglycemia (HP:0003074)2.48396698
62Parakeratosis (HP:0001036)2.46838441
63Retrobulbar optic neuritis (HP:0100654)2.40833113
64Optic neuritis (HP:0100653)2.40833113
65Nuclear cataract (HP:0100018)2.40783928
66Increased serum ferritin (HP:0003281)2.37434138
67Increased IgE level (HP:0003212)2.37223130
68Prostate neoplasm (HP:0100787)2.37135298
69Neuronal loss in central nervous system (HP:0002529)2.36709948
70Hypoalphalipoproteinemia (HP:0003233)2.36665343
71Eczematoid dermatitis (HP:0000976)2.36607741
72Tetraparesis (HP:0002273)2.35974376
73Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.32926755
74Abnormality of the periventricular white matter (HP:0002518)2.32229534
75Increased IgM level (HP:0003496)2.31827826
76Progressive neurologic deterioration (HP:0002344)2.30811175
77Hypochromic anemia (HP:0001931)2.30613749
78Abnormality of methionine metabolism (HP:0010901)2.26535444
79Glomerulonephritis (HP:0000099)2.24854110
80Abnormality of nucleobase metabolism (HP:0010932)2.24581001
81Recurrent gram-negative bacterial infections (HP:0005420)2.24231622
82Cerebral inclusion bodies (HP:0100314)2.24163475
83Poor head control (HP:0002421)2.22896265
84Amaurosis fugax (HP:0100576)2.19902533
85Gangrene (HP:0100758)2.19343589
86Impulsivity (HP:0100710)2.19077017
87Breast hypoplasia (HP:0003187)2.17244654
88Hepatosplenomegaly (HP:0001433)2.17211542
89Global brain atrophy (HP:0002283)2.16431461
90Hypoglycemic seizures (HP:0002173)2.16288424
91Keratoconjunctivitis (HP:0001096)2.15741687
92Personality changes (HP:0000751)2.15576295
93Spastic diplegia (HP:0001264)2.15198177
94Stomatitis (HP:0010280)2.14231068
95Fat malabsorption (HP:0002630)2.13269981
96Oral leukoplakia (HP:0002745)2.11840541
97Orchitis (HP:0100796)2.11508750
98Abnormality of the salivary glands (HP:0010286)2.10958780
99Aplasia/Hypoplasia of the spleen (HP:0010451)2.10359459
100Nausea (HP:0002018)2.10352814
101Acute hepatic failure (HP:0006554)2.09936504
102Gastrointestinal infarctions (HP:0005244)2.09212932
103Aplasia/Hypoplasia of the uvula (HP:0010293)2.08773840
104Recurrent fungal infections (HP:0002841)2.07327255
105Cardiomegaly (HP:0001640)2.05186859
106Rhabdomyosarcoma (HP:0002859)2.04860841
107Pseudobulbar signs (HP:0002200)2.04632620
108Tongue fasciculations (HP:0001308)2.04627997
109Dementia (HP:0000726)2.04196005
110Premature loss of primary teeth (HP:0006323)2.03277325
111Thick nail (HP:0001805)2.01581363
112Abnormality of the hepatic vasculature (HP:0006707)2.00366739
113Abnormality of the common coagulation pathway (HP:0010990)1.99431675
114Palmar hyperkeratosis (HP:0010765)1.98589305
115Abnormality of the astrocytes (HP:0100707)1.98444258
116Astrocytoma (HP:0009592)1.98444258
117Prolonged neonatal jaundice (HP:0006579)1.96595103
118Abnormality of the intrinsic pathway (HP:0010989)1.96575430
119Abnormality of the gastric mucosa (HP:0004295)1.96311401
120Hyperlipoproteinemia (HP:0010980)1.95794331
121Joint hemorrhage (HP:0005261)1.95646496
122Absent radius (HP:0003974)1.95226177
123Aplasia/hypoplasia of the humerus (HP:0006507)1.95224053
124Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94492073
125Abnormality of nail color (HP:0100643)1.94177918
126Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.93092997
127Portal hypertension (HP:0001409)1.92173515
128Birth length less than 3rd percentile (HP:0003561)1.91106883
129Protuberant abdomen (HP:0001538)1.90921258
130Abnormality of transition element cation homeostasis (HP:0011030)1.90914836
131Basal ganglia calcification (HP:0002135)1.90712249
132Congenital ichthyosiform erythroderma (HP:0007431)1.90442411
133Vertebral clefting (HP:0008428)1.90410488
134Polycythemia (HP:0001901)1.89118102
135Abnormality of serum amino acid levels (HP:0003112)1.88813525
136Complement deficiency (HP:0004431)1.88781125
137Muscle fibrillation (HP:0010546)1.87834310
138Asplenia (HP:0001746)1.87464318
139Biliary tract neoplasm (HP:0100574)1.86983798
140Short humerus (HP:0005792)1.86855530
141Recurrent skin infections (HP:0001581)1.86559010
142Palmoplantar hyperkeratosis (HP:0000972)1.85984615
143Albinism (HP:0001022)1.85902578
144Bone pain (HP:0002653)1.84671757
145Plantar hyperkeratosis (HP:0007556)1.84419155
146Agnosia (HP:0010524)1.84216835
147Type I diabetes mellitus (HP:0100651)1.83730434
148Autoimmune hemolytic anemia (HP:0001890)1.83182090
149Generalized aminoaciduria (HP:0002909)1.82917805
150Rectovaginal fistula (HP:0000143)1.82190170
151Rectal fistula (HP:0100590)1.82190170
152Chronic mucocutaneous candidiasis (HP:0002728)1.80581146
153Recurrent cutaneous fungal infections (HP:0011370)1.80581146
154Interstitial pulmonary disease (HP:0006530)1.80525125
155Flat occiput (HP:0005469)1.80444311
156Neoplasm of the oral cavity (HP:0100649)1.80310633
157Ketosis (HP:0001946)1.78778369
158Multiple lipomas (HP:0001012)1.78553086
159Carpal bone hypoplasia (HP:0001498)1.78404862
160Stenosis of the external auditory canal (HP:0000402)1.77824022
161Delayed puberty (HP:0000823)1.77579701
162IgA deficiency (HP:0002720)1.77438779
163T lymphocytopenia (HP:0005403)1.77247858
164Absent hand (HP:0004050)1.76153003
165Erythroderma (HP:0001019)1.74669873
166Abnormality of T cell number (HP:0011839)1.74392095
167Aplasia involving forearm bones (HP:0009822)1.73613939
168Absent forearm bone (HP:0003953)1.73613939
169Abnormal enzyme/coenzyme activity (HP:0012379)1.73409723
170Abnormality of the labia minora (HP:0012880)1.73352403
171Glioma (HP:0009733)1.73267056
172Abnormality of iron homeostasis (HP:0011031)1.72927389
173Symptomatic seizures (HP:0011145)1.69509181
174Pulmonary infiltrates (HP:0002113)1.65167773
175Vasculitis (HP:0002633)1.64981483
176Urticaria (HP:0001025)1.64545206
177Dysphonia (HP:0001618)1.64401352
178Upper motor neuron abnormality (HP:0002127)1.63702482
179Abnormal trabecular bone morphology (HP:0100671)1.63672797
180Keratoconjunctivitis sicca (HP:0001097)1.63240763
181Gastrointestinal stroma tumor (HP:0100723)1.60072065
182Thoracic kyphosis (HP:0002942)1.59936778
183Progressive external ophthalmoplegia (HP:0000590)1.59659843
184Abnormality of the prostate (HP:0008775)1.57229756
185Abnormality of the basal ganglia (HP:0002134)1.55268978
186Abnormality of the axillary hair (HP:0100134)1.54237830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.85532469
2MAP3K144.83204937
3EPHA23.77049768
4CDK123.50852935
5IKBKB2.76982957
6GRK72.64511467
7CHUK2.50335079
8MATK2.47765589
9AKT32.45337311
10TAOK22.34925525
11TYK22.20853890
12NEK12.16371125
13FGFR42.05597281
14FLT32.04526664
15WEE12.03566881
16MAP3K111.94345368
17PIM21.86493222
18ADRBK21.80771167
19DDR21.75008413
20MAP3K131.72173705
21FGR1.70688859
22DYRK31.65321398
23TBK11.65129082
24BCKDK1.64987596
25JAK31.61219305
26RPS6KB21.56574273
27TTK1.54778678
28PBK1.54766018
29MAP3K91.51473408
30NEK21.47822888
31IRAK31.45554834
32BLK1.40553962
33PIM11.38983431
34TAF11.34440852
35PRPF4B1.33682410
36MAPKAPK31.31522184
37ABL21.31497205
38STK38L1.31049847
39MAP3K121.30165346
40MAP3K101.29538217
41TSSK61.28739771
42RIPK41.25827897
43TAOK11.20183461
44MAP3K31.19593354
45ERBB41.16876181
46TRIB31.16156380
47PASK1.15566743
48DYRK1B1.15552813
49STK41.13081089
50CSF1R1.13079976
51IKBKE1.11516452
52PRKAA21.10046068
53LATS11.09641864
54PLK11.09239146
55JAK11.05351854
56IRAK41.05138278
57SIK31.03946776
58MST41.03406728
59BUB11.02609291
60PTK61.01747108
61ZAK1.01470150
62MUSK1.00521658
63CDK41.00399479
64NEK61.00255946
65TYRO30.98973902
66STK30.97027870
67BMPR20.94791917
68CDK70.94388766
69EPHA30.92370591
70BCR0.92172419
71RIPK10.92039201
72EPHB10.89536404
73CAMKK20.88026897
74CHEK20.86501570
75MAP3K10.84510076
76MET0.84486335
77LIMK10.84009173
78ICK0.83750357
79ACVR1B0.80917826
80ALK0.80738895
81JAK20.79662426
82FGFR30.79266127
83CHEK10.78709693
84MAP3K80.78349654
85NEK90.78316602
86EIF2AK20.76833614
87EIF2AK30.76633728
88PAK40.76140764
89SRPK10.75698752
90INSRR0.75545412
91RPS6KA40.75082637
92ATR0.74864653
93BMX0.73939646
94MTOR0.71641613
95CDC70.71023033
96SMG10.70003697
97TGFBR10.69961710
98MOS0.69838178
99DAPK20.69298005
100BRSK20.68156475
101MAP4K10.68076188
102CDK60.67585948
103RPS6KA10.66748506
104MAPK150.64623442
105BRD40.64495332
106IRAK20.64281608
107MELK0.63712549
108CDC42BPA0.62658169
109DAPK10.62525584
110SCYL20.61824515
111TXK0.60436355
112MAPK110.60097662
113RPS6KA20.59623155
114TLK10.59547328
115ATM0.58528169
116STK100.57844833
117PRKAA10.57508096
118MAPKAPK50.57331942
119AURKB0.57018664
120PLK30.56598726
121GRK60.54815653
122PKN20.53809143
123RPS6KB10.53716624
124SIK10.53008461
125MAPKAPK20.52877229
126LYN0.52320710
127MAP2K60.51297247
128GSK3A0.50509096
129PDPK10.50305959
130CDK20.48813077
131TESK10.48388563
132CAMK1D0.47997672
133MARK30.47905904
134BRAF0.47687353
135STK240.47357574
136PKN10.46786359
137CSK0.45868169
138CLK10.45618618
139MAP2K30.45273245
140PIK3CA0.44099147
141TESK20.44000671
142PLK40.42013664
143PRKCI0.41957616
144AKT10.41905180
145CAMKK10.41870313
146RPS6KA50.41439289
147TTN0.41265522
148AURKA0.40872452
149RPS6KA60.40615572
150RPS6KC10.40572702
151RPS6KL10.40572702
152PDK10.40571344
153EIF2AK10.39872614
154CSNK1D0.39102348
155MAP3K50.38200229
156ABL10.36768003
157LCK0.35655749
158FER0.34936860
159MKNK10.30063546
160LATS20.30017725
161SYK0.28814857

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.90116188
2Lysosome_Homo sapiens_hsa041423.80572122
3Rheumatoid arthritis_Homo sapiens_hsa053233.38148382
4Other glycan degradation_Homo sapiens_hsa005112.93857944
5Asthma_Homo sapiens_hsa053102.77818973
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.69169929
7Arginine biosynthesis_Homo sapiens_hsa002202.44305870
8One carbon pool by folate_Homo sapiens_hsa006702.42245230
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.41857112
10Nitrogen metabolism_Homo sapiens_hsa009102.21857148
11Selenocompound metabolism_Homo sapiens_hsa004502.19934102
12Tryptophan metabolism_Homo sapiens_hsa003802.15254688
13Tuberculosis_Homo sapiens_hsa051522.08319314
14Osteoclast differentiation_Homo sapiens_hsa043802.07903879
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02177354
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.00624744
17Phenylalanine metabolism_Homo sapiens_hsa003601.98726718
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.96183567
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.94252637
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79832039
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.76670109
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76239610
23Collecting duct acid secretion_Homo sapiens_hsa049661.73235799
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64136586
25Pertussis_Homo sapiens_hsa051331.62165402
26Histidine metabolism_Homo sapiens_hsa003401.59424677
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58710473
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57534080
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.56341003
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56150155
31Phagosome_Homo sapiens_hsa041451.55174253
32Malaria_Homo sapiens_hsa051441.52513802
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.49031457
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.48621477
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47919639
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.47484602
37Folate biosynthesis_Homo sapiens_hsa007901.40940208
38Allograft rejection_Homo sapiens_hsa053301.38393001
39Bladder cancer_Homo sapiens_hsa052191.36762855
40p53 signaling pathway_Homo sapiens_hsa041151.36448654
41Biosynthesis of amino acids_Homo sapiens_hsa012301.32469346
42Tyrosine metabolism_Homo sapiens_hsa003501.31665904
43Sphingolipid metabolism_Homo sapiens_hsa006001.31010699
44Antigen processing and presentation_Homo sapiens_hsa046121.30738079
45Complement and coagulation cascades_Homo sapiens_hsa046101.29848623
46Fatty acid degradation_Homo sapiens_hsa000711.27881764
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.27312547
48Viral myocarditis_Homo sapiens_hsa054161.26231379
49Graft-versus-host disease_Homo sapiens_hsa053321.24015080
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23814178
51Mismatch repair_Homo sapiens_hsa034301.22152877
52Salmonella infection_Homo sapiens_hsa051321.19331336
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19096947
54B cell receptor signaling pathway_Homo sapiens_hsa046621.16378891
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16195375
56Hepatitis C_Homo sapiens_hsa051601.15269225
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14780218
58RNA transport_Homo sapiens_hsa030131.12436581
59Intestinal immune network for IgA production_Homo sapiens_hsa046721.10222681
60Legionellosis_Homo sapiens_hsa051341.10169348
61Proteasome_Homo sapiens_hsa030501.09752042
62Vibrio cholerae infection_Homo sapiens_hsa051101.09097578
63Staphylococcus aureus infection_Homo sapiens_hsa051501.06121155
64Hematopoietic cell lineage_Homo sapiens_hsa046401.06074190
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05840636
66Steroid biosynthesis_Homo sapiens_hsa001001.05709503
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04779390
68Chemical carcinogenesis_Homo sapiens_hsa052041.03786534
69African trypanosomiasis_Homo sapiens_hsa051430.97576054
70Peroxisome_Homo sapiens_hsa041460.95683587
71DNA replication_Homo sapiens_hsa030300.95407835
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93946225
73Retinol metabolism_Homo sapiens_hsa008300.93598146
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92677222
75Fructose and mannose metabolism_Homo sapiens_hsa000510.92474052
76Chemokine signaling pathway_Homo sapiens_hsa040620.90847274
77Apoptosis_Homo sapiens_hsa042100.90464247
78Carbon metabolism_Homo sapiens_hsa012000.89171058
79beta-Alanine metabolism_Homo sapiens_hsa004100.89087308
80Herpes simplex infection_Homo sapiens_hsa051680.87162503
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85908001
82Sulfur metabolism_Homo sapiens_hsa009200.85532092
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84296671
84Hepatitis B_Homo sapiens_hsa051610.84019700
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82154918
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81660618
87Shigellosis_Homo sapiens_hsa051310.80442951
88TNF signaling pathway_Homo sapiens_hsa046680.80158429
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76794235
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76146836
91Epstein-Barr virus infection_Homo sapiens_hsa051690.75758421
92PPAR signaling pathway_Homo sapiens_hsa033200.74638896
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.73115867
94Linoleic acid metabolism_Homo sapiens_hsa005910.71645042
95ABC transporters_Homo sapiens_hsa020100.71434392
96Autoimmune thyroid disease_Homo sapiens_hsa053200.71318898
97Acute myeloid leukemia_Homo sapiens_hsa052210.70764493
98Arginine and proline metabolism_Homo sapiens_hsa003300.70161572
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68398104
100Pentose phosphate pathway_Homo sapiens_hsa000300.68044571
101Leishmaniasis_Homo sapiens_hsa051400.67261940
102Prolactin signaling pathway_Homo sapiens_hsa049170.66882607
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66687008
104Starch and sucrose metabolism_Homo sapiens_hsa005000.65552156
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64126418
106Prion diseases_Homo sapiens_hsa050200.63957115
107Type I diabetes mellitus_Homo sapiens_hsa049400.63605590
108Viral carcinogenesis_Homo sapiens_hsa052030.61177571
109Small cell lung cancer_Homo sapiens_hsa052220.60830907
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60177282
111Base excision repair_Homo sapiens_hsa034100.59282871
112Homologous recombination_Homo sapiens_hsa034400.56886397
113Primary immunodeficiency_Homo sapiens_hsa053400.56212672
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54172694
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.54034248
116Toxoplasmosis_Homo sapiens_hsa051450.53306403
117Cell cycle_Homo sapiens_hsa041100.52565507
118Fat digestion and absorption_Homo sapiens_hsa049750.52561190
119Mineral absorption_Homo sapiens_hsa049780.52354487
120Propanoate metabolism_Homo sapiens_hsa006400.52291946
121Lysine degradation_Homo sapiens_hsa003100.52138750
122Butanoate metabolism_Homo sapiens_hsa006500.52117281
123Glutathione metabolism_Homo sapiens_hsa004800.51449797
124Influenza A_Homo sapiens_hsa051640.50494906
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.50451722
126T cell receptor signaling pathway_Homo sapiens_hsa046600.49718087
127RNA polymerase_Homo sapiens_hsa030200.49340147
128Fatty acid metabolism_Homo sapiens_hsa012120.49293676
129VEGF signaling pathway_Homo sapiens_hsa043700.48777330
130Measles_Homo sapiens_hsa051620.48270941
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48170470
132Vitamin digestion and absorption_Homo sapiens_hsa049770.48006330
133Vitamin B6 metabolism_Homo sapiens_hsa007500.47754164
134Spliceosome_Homo sapiens_hsa030400.47707897
135Insulin resistance_Homo sapiens_hsa049310.47327131
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46248748
137Systemic lupus erythematosus_Homo sapiens_hsa053220.46214738
138Sulfur relay system_Homo sapiens_hsa041220.44876370
139Caffeine metabolism_Homo sapiens_hsa002320.43594374
140Galactose metabolism_Homo sapiens_hsa000520.41454061
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41067925
142Fanconi anemia pathway_Homo sapiens_hsa034600.40082445
143Nucleotide excision repair_Homo sapiens_hsa034200.39286293
144Ether lipid metabolism_Homo sapiens_hsa005650.38558068
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.35236089
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32149525
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30898670
148Amoebiasis_Homo sapiens_hsa051460.30181085
149HIF-1 signaling pathway_Homo sapiens_hsa040660.27932495
150Type II diabetes mellitus_Homo sapiens_hsa049300.25498518
151Thyroid cancer_Homo sapiens_hsa052160.24630073
152Neurotrophin signaling pathway_Homo sapiens_hsa047220.24087472
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24061274
154HTLV-I infection_Homo sapiens_hsa051660.21506620
155Fatty acid elongation_Homo sapiens_hsa000620.21142176
156Synaptic vesicle cycle_Homo sapiens_hsa047210.20037997
157AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.17837341
158Renal cell carcinoma_Homo sapiens_hsa052110.15636229
159SNARE interactions in vesicular transport_Homo sapiens_hsa041300.11984889

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »