MRFAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)8.26471919
2COPI coating of Golgi vesicle (GO:0048205)8.26471919
3signal peptide processing (GO:0006465)6.14889467
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.09045124
5protein maturation by protein folding (GO:0022417)5.72271811
6protein retention in ER lumen (GO:0006621)5.37482282
7ER overload response (GO:0006983)4.70381582
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.50358999
9cullin deneddylation (GO:0010388)4.32055281
10COPII vesicle coating (GO:0048208)4.16590407
11intraciliary transport (GO:0042073)4.12008124
12glandular epithelial cell differentiation (GO:0002067)4.11720405
13endocrine pancreas development (GO:0031018)3.97055679
14sequestering of metal ion (GO:0051238)3.93601038
15synaptic vesicle maturation (GO:0016188)3.89817715
16glutamate secretion (GO:0014047)3.86420631
17peptide hormone processing (GO:0016486)3.83885781
18protein deneddylation (GO:0000338)3.82204624
19regulation of type B pancreatic cell apoptotic process (GO:2000674)3.66479234
20sodium ion export (GO:0071436)3.63482312
21regulation of short-term neuronal synaptic plasticity (GO:0048172)3.46681228
22synaptic vesicle exocytosis (GO:0016079)3.45555451
23synaptic vesicle docking involved in exocytosis (GO:0016081)3.42893804
24regulation of synaptic vesicle exocytosis (GO:2000300)3.39962045
25establishment of mitochondrion localization (GO:0051654)3.38298235
26cellular potassium ion homeostasis (GO:0030007)3.32564062
27heart contraction (GO:0060047)3.31424600
28heart process (GO:0003015)3.31424600
29type B pancreatic cell development (GO:0003323)3.30232292
30layer formation in cerebral cortex (GO:0021819)3.28935945
31vesicle coating (GO:0006901)3.28371782
32deoxyribose phosphate biosynthetic process (GO:0046385)3.24027418
332-deoxyribonucleotide biosynthetic process (GO:0009265)3.24027418
34GDP-mannose metabolic process (GO:0019673)3.20555987
35glandular epithelial cell development (GO:0002068)3.12138126
36chaperone-mediated protein folding (GO:0061077)3.09538413
37insulin secretion (GO:0030073)3.01383866
38postsynaptic membrane organization (GO:0001941)3.01334933
39ER to Golgi vesicle-mediated transport (GO:0006888)2.95221930
40regulation of insulin secretion (GO:0050796)2.93643948
41negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.92917406
42regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.90638561
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.89543446
44regulation of glucokinase activity (GO:0033131)2.89028929
45regulation of hexokinase activity (GO:1903299)2.89028929
46protein refolding (GO:0042026)2.88357001
47deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.87382408
48positive regulation of insulin secretion (GO:0032024)2.87245205
49regulation of male gonad development (GO:2000018)2.85719141
50negative regulation of insulin secretion (GO:0046676)2.78535432
51negative regulation of microtubule polymerization (GO:0031115)2.78150241
52regulation of synaptic vesicle transport (GO:1902803)2.77514186
53pharyngeal system development (GO:0060037)2.77168087
54exocrine pancreas development (GO:0031017)2.76877183
55regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.74687154
56activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.74515944
57neuron recognition (GO:0008038)2.74037718
58cell communication by electrical coupling (GO:0010644)2.71547480
59inositol phosphate catabolic process (GO:0071545)2.71239152
60neurotransmitter secretion (GO:0007269)2.70273698
61cell migration in hindbrain (GO:0021535)2.69109926
62protein peptidyl-prolyl isomerization (GO:0000413)2.68421829
63nucleotide transmembrane transport (GO:1901679)2.68360887
64establishment of integrated proviral latency (GO:0075713)2.67718653
65mating behavior (GO:0007617)2.67439684
66regulation of peptide hormone secretion (GO:0090276)2.65643558
67neuronal ion channel clustering (GO:0045161)2.65075216
68regulation of glucocorticoid secretion (GO:2000849)2.64633466
69cerebellar Purkinje cell layer development (GO:0021680)2.63913808
70positive regulation of nuclease activity (GO:0032075)2.62817148
71establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.62799388
72mitochondrion transport along microtubule (GO:0047497)2.62799388
73synaptic vesicle endocytosis (GO:0048488)2.62430450
74axonal fasciculation (GO:0007413)2.61721265
75positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.61354647
76negative regulation of glycogen biosynthetic process (GO:0045719)2.61291577
77neuron cell-cell adhesion (GO:0007158)2.61079435
78regulation of peptide secretion (GO:0002791)2.60538253
79neuron fate specification (GO:0048665)2.58688818
80amino acid import (GO:0043090)2.58668192
81regulation of mitochondrial translation (GO:0070129)2.58639674
82ganglion development (GO:0061548)2.58138337
83peptidyl-arginine omega-N-methylation (GO:0035247)2.58004759
84negative regulation of JUN kinase activity (GO:0043508)2.57392627
85regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.56771779
86apical protein localization (GO:0045176)2.56303456
87protein localization to synapse (GO:0035418)2.55608959
88deoxyribonucleotide biosynthetic process (GO:0009263)2.55049148
89protein N-linked glycosylation via asparagine (GO:0018279)2.54651167
90misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.54549533
91cerebellar granule cell differentiation (GO:0021707)2.54479279
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54091470
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54091470
94intra-Golgi vesicle-mediated transport (GO:0006891)2.51505279
95peptidyl-asparagine modification (GO:0018196)2.48940446
96cellular response to topologically incorrect protein (GO:0035967)2.48020514
97negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.47743532
98ribonucleoprotein complex disassembly (GO:0032988)2.47028930
99adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.46596071
100ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.46337927
101de novo protein folding (GO:0006458)2.45996889
102presynaptic membrane organization (GO:0097090)2.45491172
103de novo posttranslational protein folding (GO:0051084)2.44894713
104dendritic spine organization (GO:0097061)2.44827773
105negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.44818117
106pyrimidine nucleobase catabolic process (GO:0006208)2.44620528
107regulation of neuronal synaptic plasticity (GO:0048168)2.44075085
108regulation of hormone secretion (GO:0046883)2.44066141
109regulation of nuclease activity (GO:0032069)2.43979106
110nucleobase-containing small molecule interconversion (GO:0015949)2.43842639
111melanosome transport (GO:0032402)2.43776170
112guanosine-containing compound biosynthetic process (GO:1901070)2.43706569
113axon extension (GO:0048675)2.43345257
114positive regulation of cellular response to oxidative stress (GO:1900409)2.42433775
115positive regulation of response to oxidative stress (GO:1902884)2.42433775
116peptidyl-arginine methylation (GO:0018216)2.42272095
117peptidyl-arginine N-methylation (GO:0035246)2.42272095
118cellular response to unfolded protein (GO:0034620)2.40871700
119substantia nigra development (GO:0021762)2.40838198
120negative regulation of peptide hormone secretion (GO:0090278)2.40805936
121L-serine metabolic process (GO:0006563)2.40125411
122potassium ion homeostasis (GO:0055075)2.39568051
123membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.39140496
124mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.38998187
125vocalization behavior (GO:0071625)2.38687025
126nephron tubule morphogenesis (GO:0072078)2.38538691
127nephron epithelium morphogenesis (GO:0072088)2.38538691
128chaperone-mediated protein transport (GO:0072321)2.38435521
129endoplasmic reticulum unfolded protein response (GO:0030968)2.37299100
130cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.36948368
131regulation of secondary heart field cardioblast proliferation (GO:0003266)2.36419734
132regulation of cardioblast proliferation (GO:0003264)2.36419734
133detection of calcium ion (GO:0005513)2.34703905
134GMP metabolic process (GO:0046037)2.34694304
135asymmetric protein localization (GO:0008105)2.34199305
136protein complex biogenesis (GO:0070271)2.33885509
137protein N-linked glycosylation (GO:0006487)2.33356131
138dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.33281981
139positive regulation of synapse maturation (GO:0090129)2.33012686
140peptidyl-histidine modification (GO:0018202)2.31831182
141signal transduction involved in regulation of gene expression (GO:0023019)2.31813222
142establishment of melanosome localization (GO:0032401)2.30135631
143negative regulation of peptide secretion (GO:0002792)2.29707607
144viral protein processing (GO:0019082)2.29419354
145positive regulation of male gonad development (GO:2000020)2.28998099
146pigment granule transport (GO:0051904)2.28772061
147membrane repolarization during action potential (GO:0086011)2.28478640
148nitric oxide mediated signal transduction (GO:0007263)2.28152896
149establishment of viral latency (GO:0019043)2.27834737
150negative regulation of calcium ion transmembrane transport (GO:1903170)2.27585225
151negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.27585225
152body morphogenesis (GO:0010171)2.27549322
153positive regulation of mitochondrial fission (GO:0090141)2.27439233
154peptide hormone secretion (GO:0030072)2.27302839
155relaxation of smooth muscle (GO:0044557)2.26042632
156protein complex localization (GO:0031503)2.25659410
157presynaptic membrane assembly (GO:0097105)2.24567439
158exploration behavior (GO:0035640)2.22051456
159neuron projection extension (GO:1990138)2.21737723
160regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.19701558
161histone arginine methylation (GO:0034969)2.18775491
162chaperone-mediated protein complex assembly (GO:0051131)2.18661026
163locomotory exploration behavior (GO:0035641)2.18568079
164paraxial mesoderm development (GO:0048339)2.17647814
165positive regulation of synapse assembly (GO:0051965)2.17307897
166positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.15787414
167negative regulation of synaptic transmission, GABAergic (GO:0032229)2.15550300
168axon cargo transport (GO:0008088)2.13524583
169substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.10186815
170substrate-independent telencephalic tangential migration (GO:0021826)2.10186815
171positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.09961135
172histone H2B ubiquitination (GO:0033523)2.09091932
173neuromuscular process controlling balance (GO:0050885)2.08794967
174positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.08647670
175regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.08647670
176glycolytic process (GO:0006096)2.08138329
177ionotropic glutamate receptor signaling pathway (GO:0035235)2.05529423
178neurotransmitter transport (GO:0006836)2.05141709
179synapse assembly (GO:0007416)2.05094067
180dendrite morphogenesis (GO:0048813)2.03966265
181negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.03434547
182peptidyl-cysteine modification (GO:0018198)2.02602959
183cellular sodium ion homeostasis (GO:0006883)2.02456531
184ephrin receptor signaling pathway (GO:0048013)2.02227485
1854-hydroxyproline metabolic process (GO:0019471)2.01844614
186dopamine receptor signaling pathway (GO:0007212)2.01639580
187central nervous system myelination (GO:0022010)2.00881825
188axon ensheathment in central nervous system (GO:0032291)2.00881825
189proline biosynthetic process (GO:0006561)2.00729265
190gluconeogenesis (GO:0006094)1.99318803
191regulation of vesicle fusion (GO:0031338)1.98448563
192neurofilament cytoskeleton organization (GO:0060052)1.98175168
193growth hormone secretion (GO:0030252)1.97831648
194transmission of nerve impulse (GO:0019226)1.97668271

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.47282498
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.11676384
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.96730199
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.84338678
5PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.57981656
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.34857843
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.16379410
8PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.85671143
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.75638372
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64548155
11ELK1_19687146_ChIP-ChIP_HELA_Human2.60045286
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49423549
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41154306
14PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.36251821
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23490871
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11333081
17FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.09612260
18VDR_22108803_ChIP-Seq_LS180_Human2.03380094
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02539233
20ZFP281_18757296_ChIP-ChIP_E14_Mouse2.00454546
21CLOCK_20551151_ChIP-Seq_293T_Human1.97219614
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92579245
23WT1_19549856_ChIP-ChIP_CCG9911_Human1.88084451
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86937212
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.86762763
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.86497139
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82365245
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80469917
29ZNF263_19887448_ChIP-Seq_K562_Human1.80193525
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77622328
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75418649
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74863710
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74303169
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.73282987
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69855398
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69214099
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66924842
38VDR_23849224_ChIP-Seq_CD4+_Human1.66181853
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66157079
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65926036
41* ETS1_20019798_ChIP-Seq_JURKAT_Human1.65797197
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65638654
43DCP1A_22483619_ChIP-Seq_HELA_Human1.64609363
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63766899
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.61191230
46AR_21909140_ChIP-Seq_LNCAP_Human1.60915277
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58643466
48* GABP_19822575_ChIP-Seq_HepG2_Human1.57253485
49TFEB_21752829_ChIP-Seq_HELA_Human1.56785162
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52834558
51REST_19997604_ChIP-ChIP_NEURONS_Mouse1.51586673
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49895039
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.47910748
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43737988
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43508936
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42794995
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.42209479
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.39559560
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.39559560
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.39498565
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.39140269
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.38673706
63EZH2_22144423_ChIP-Seq_EOC_Human1.38544063
64SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.36674803
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36444845
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.35165732
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34122501
68FUS_26573619_Chip-Seq_HEK293_Human1.32684394
69EWS_26573619_Chip-Seq_HEK293_Human1.31624979
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28674518
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28539107
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27874115
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27704423
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26777241
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25585998
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25397307
77* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24823019
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24789579
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24771113
80SOX17_20123909_ChIP-Seq_XEN_Mouse1.24303009
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22892978
82IGF1R_20145208_ChIP-Seq_DFB_Human1.22759176
83MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22400693
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20132842
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19411386
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.19201092
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19024881
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18801296
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18573446
90TET1_21490601_ChIP-Seq_MESCs_Mouse1.17829869
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17432143
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16987641
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16675700
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15262911
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15105121
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14897786
97TRIM28_21343339_ChIP-Seq_HEK293_Human1.14831013
98REST_21632747_ChIP-Seq_MESCs_Mouse1.13645167
99* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13401045
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13164260
101SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12503524
102MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12000023
103JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11940806
104NANOG_21062744_ChIP-ChIP_HESCs_Human1.11568317
105TTF2_22483619_ChIP-Seq_HELA_Human1.09936013
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09415834
107GBX2_23144817_ChIP-Seq_PC3_Human1.08971050
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08883824
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08733317
110EZH2_27294783_Chip-Seq_ESCs_Mouse1.08698325
111GATA1_26923725_Chip-Seq_HPCs_Mouse1.08533181
112POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07699893
113* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07626317
114HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07266479
115* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07188744
116JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07030612
117ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06093328
118FOXP3_21729870_ChIP-Seq_TREG_Human1.05750721
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05598696
120SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05368759
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05168769
122NANOG_16153702_ChIP-ChIP_HESCs_Human1.05149112
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04344380
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03826046
125* RNF2_27304074_Chip-Seq_ESCs_Mouse1.03074760
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02085855
127ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01879818
128SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01385532
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01309228
130BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01007145
131POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00963238
132* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00880555
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00837232
134EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00759685
135E2F7_22180533_ChIP-Seq_HELA_Human1.00238486
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99875977
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98888368
138SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98386617
139ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97679663
140TP53_22573176_ChIP-Seq_HFKS_Human0.94600535
141CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94104577
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93558031
143TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93092457
144* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.90837260
145P300_19829295_ChIP-Seq_ESCs_Human0.90453465
146* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.90002183
147ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89421684
148NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89270210
149* XRN2_22483619_ChIP-Seq_HELA_Human0.89263540
150CHD1_26751641_Chip-Seq_LNCaP_Human0.87682678
151GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87595383
152SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84988107
153E2F1_21310950_ChIP-Seq_MCF-7_Human0.84432871
154SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84344893
155ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83965512
156YY1_21170310_ChIP-Seq_MESCs_Mouse0.83608834
157FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.81396795
158GF1B_26923725_Chip-Seq_HPCs_Mouse0.81031384
159SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79598846
160SOX2_16153702_ChIP-ChIP_HESCs_Human0.79022029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.55791988
2MP0003122_maternal_imprinting4.08461170
3MP0004859_abnormal_synaptic_plasticity3.93467868
4MP0003123_paternal_imprinting3.25560596
5MP0003880_abnormal_central_pattern2.79632784
6MP0010386_abnormal_urinary_bladder2.75025718
7MP0000013_abnormal_adipose_tissue2.71464482
8MP0000678_abnormal_parathyroid_gland2.67198950
9MP0003283_abnormal_digestive_organ2.62160937
10MP0005379_endocrine/exocrine_gland_phen2.61767860
11MP0003121_genomic_imprinting2.59774068
12MP0004043_abnormal_pH_regulation2.42692137
13MP0003787_abnormal_imprinting2.42421055
14MP0005423_abnormal_somatic_nervous2.36326376
15MP0002163_abnormal_gland_morphology2.23381137
16MP0003195_calcinosis2.17606125
17MP0002638_abnormal_pupillary_reflex2.16894776
18MP0006072_abnormal_retinal_apoptosis2.11193942
19MP0002693_abnormal_pancreas_physiology2.09619855
20MP0003635_abnormal_synaptic_transmissio2.06748266
21MP0001944_abnormal_pancreas_morphology2.03767653
22MP0009780_abnormal_chondrocyte_physiolo2.02254164
23MP0000778_abnormal_nervous_system1.98837092
24MP0002909_abnormal_adrenal_gland1.90047082
25MP0001529_abnormal_vocalization1.86348824
26MP0001986_abnormal_taste_sensitivity1.86318800
27MP0005646_abnormal_pituitary_gland1.73754405
28MP0002063_abnormal_learning/memory/cond1.70217907
29MP0003329_amyloid_beta_deposits1.67702083
30MP0005623_abnormal_meninges_morphology1.65048030
31MP0002837_dystrophic_cardiac_calcinosis1.60637852
32MP0003119_abnormal_digestive_system1.57806167
33MP0005645_abnormal_hypothalamus_physiol1.57679009
34MP0002064_seizures1.56985281
35MP0008789_abnormal_olfactory_epithelium1.56147956
36MP0010030_abnormal_orbit_morphology1.55239241
37MP0005220_abnormal_exocrine_pancreas1.54524946
38MP0002938_white_spotting1.52885818
39MP0002751_abnormal_autonomic_nervous1.48459253
40MP0000955_abnormal_spinal_cord1.47586069
41MP0008877_abnormal_DNA_methylation1.44665785
42MP0004811_abnormal_neuron_physiology1.42995264
43MP0003942_abnormal_urinary_system1.42632925
44MP0002572_abnormal_emotion/affect_behav1.42211844
45MP0002160_abnormal_reproductive_system1.39938190
46MP0006054_spinal_hemorrhage1.39865786
47MP0002736_abnormal_nociception_after1.37909492
48MP0005503_abnormal_tendon_morphology1.37129915
49MP0001188_hyperpigmentation1.36872780
50MP0005367_renal/urinary_system_phenotyp1.36345250
51MP0000516_abnormal_urinary_system1.36345250
52MP0006276_abnormal_autonomic_nervous1.35450045
53MP0000631_abnormal_neuroendocrine_gland1.34959864
54MP0003183_abnormal_peptide_metabolism1.34461236
55MP0009745_abnormal_behavioral_response1.34219689
56MP0001984_abnormal_olfaction1.34059121
57MP0004858_abnormal_nervous_system1.33146358
58MP0009046_muscle_twitch1.29104005
59MP0002184_abnormal_innervation1.27807353
60MP0003890_abnormal_embryonic-extraembry1.27441645
61MP0006292_abnormal_olfactory_placode1.25329060
62MP0000751_myopathy1.24489692
63MP0002272_abnormal_nervous_system1.24343960
64MP0005171_absent_coat_pigmentation1.23071469
65MP0009697_abnormal_copulation1.19996309
66MP0001486_abnormal_startle_reflex1.18129629
67MP0000579_abnormal_nail_morphology1.17795702
68MP0000566_synostosis1.17640206
69MP0002009_preneoplasia1.17237563
70MP0005499_abnormal_olfactory_system1.17124177
71MP0005394_taste/olfaction_phenotype1.17124177
72MP0000049_abnormal_middle_ear1.16613404
73MP0002152_abnormal_brain_morphology1.16204883
74MP0000003_abnormal_adipose_tissue1.15803636
75MP0002822_catalepsy1.15669046
76MP0002882_abnormal_neuron_morphology1.15210231
77MP0005248_abnormal_Harderian_gland1.13735861
78MP0005257_abnormal_intraocular_pressure1.13263086
79MP0005389_reproductive_system_phenotype1.12740622
80MP0001968_abnormal_touch/_nociception1.12491656
81MP0005408_hypopigmentation1.11692538
82MP0003861_abnormal_nervous_system1.11396880
83MP0002896_abnormal_bone_mineralization1.10431688
84MP0002876_abnormal_thyroid_physiology1.09732895
85MP0002557_abnormal_social/conspecific_i1.09603838
86MP0008007_abnormal_cellular_replicative1.07287875
87MP0002234_abnormal_pharynx_morphology1.07152194
88MP0003705_abnormal_hypodermis_morpholog1.06819747
89MP0002735_abnormal_chemical_nociception1.05761698
90MP0003634_abnormal_glial_cell1.05628544
91MP0005187_abnormal_penis_morphology1.04311991
92MP0000534_abnormal_ureter_morphology1.03697229
93MP0001177_atelectasis1.02408486
94MP0002066_abnormal_motor_capabilities/c1.01633153
95MP0001299_abnormal_eye_distance/1.01524896
96MP0003136_yellow_coat_color1.01214672
97MP0004782_abnormal_surfactant_physiolog1.00647166
98MP0000613_abnormal_salivary_gland0.99477826
99MP0004133_heterotaxia0.99271933
100MP0000762_abnormal_tongue_morphology0.98581291
101MP0002653_abnormal_ependyma_morphology0.97554334
102MP0004885_abnormal_endolymph0.96898423
103MP0009250_abnormal_appendicular_skeleto0.96507887
104MP0002090_abnormal_vision0.95779371
105MP0002249_abnormal_larynx_morphology0.95313286
106MP0001919_abnormal_reproductive_system0.94356253
107MP0001970_abnormal_pain_threshold0.94271778
108MP0009053_abnormal_anal_canal0.94128738
109MP0001502_abnormal_circadian_rhythm0.93094617
110MP0004233_abnormal_muscle_weight0.92111700
111MP0000537_abnormal_urethra_morphology0.92062577
112MP0003693_abnormal_embryo_hatching0.91815312
113MP0008569_lethality_at_weaning0.91578961
114MP0005508_abnormal_skeleton_morphology0.89966118
115MP0002067_abnormal_sensory_capabilities0.89928793
116MP0002697_abnormal_eye_size0.89633885
117MP0004264_abnormal_extraembryonic_tissu0.89614190
118MP0005253_abnormal_eye_physiology0.88431371
119MP0003385_abnormal_body_wall0.88015824
120MP0002078_abnormal_glucose_homeostasis0.87756078
121MP0003941_abnormal_skin_development0.87735939
122MP0003315_abnormal_perineum_morphology0.87137897
123MP0005084_abnormal_gallbladder_morpholo0.86515025
124MP0010234_abnormal_vibrissa_follicle0.85882650
125MP0002177_abnormal_outer_ear0.85359287
126MP0002733_abnormal_thermal_nociception0.83524498
127MP0008438_abnormal_cutaneous_collagen0.83265947
128MP0001346_abnormal_lacrimal_gland0.83029949
129MP0004957_abnormal_blastocyst_morpholog0.82934712
130MP0000163_abnormal_cartilage_morphology0.82082331
131MP0004272_abnormal_basement_membrane0.81663566
132MP0000747_muscle_weakness0.81546271
133MP0001270_distended_abdomen0.81314107
134MP0000681_abnormal_thyroid_gland0.80549973
135MP0001293_anophthalmia0.80440971
136MP0003938_abnormal_ear_development0.80071705
137MP0004270_analgesia0.80009424
138MP0001542_abnormal_bone_strength0.79530606
139MP0001730_embryonic_growth_arrest0.79234633
140MP0003879_abnormal_hair_cell0.78536794
141MP0000749_muscle_degeneration0.78145149
142MP0000428_abnormal_craniofacial_morphol0.78023234
143MP0003755_abnormal_palate_morphology0.77381149
144MP0002752_abnormal_somatic_nervous0.77045029
145MP0000372_irregular_coat_pigmentation0.76509287
146MP0002081_perinatal_lethality0.76501940
147MP0001905_abnormal_dopamine_level0.76489607
148MP0000462_abnormal_digestive_system0.75959886
149MP0000026_abnormal_inner_ear0.75600267
150MP0009703_decreased_birth_body0.75220199
151MP0008932_abnormal_embryonic_tissue0.74737350
152MP0003943_abnormal_hepatobiliary_system0.74394248
153MP0002092_abnormal_eye_morphology0.74018199
154MP0001727_abnormal_embryo_implantation0.73846282
155MP0008260_abnormal_autophagy0.73558130
156MP0002233_abnormal_nose_morphology0.73309430
157MP0003937_abnormal_limbs/digits/tail_de0.72595177
158MP0002085_abnormal_embryonic_tissue0.71525230
159MP0002116_abnormal_craniofacial_bone0.70361776
160MP0002734_abnormal_mechanical_nocicepti0.69802477
161MP0000538_abnormal_urinary_bladder0.69425279
162MP0001485_abnormal_pinna_reflex0.69175570
163MP0009672_abnormal_birth_weight0.68986855
164MP0004145_abnormal_muscle_electrophysio0.68575864
165MP0003115_abnormal_respiratory_system0.67507031

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)4.57017524
2Hyperinsulinemic hypoglycemia (HP:0000825)4.41541541
3Symptomatic seizures (HP:0011145)4.37221891
4Myokymia (HP:0002411)4.18255849
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.03992469
6Abnormal pancreas size (HP:0012094)4.03223556
7Abnormality of the anterior horn cell (HP:0006802)3.58663232
8Degeneration of anterior horn cells (HP:0002398)3.58663232
9Hypothermia (HP:0002045)3.41467125
10Pancreatic islet-cell hyperplasia (HP:0004510)3.37251526
11Hypoglycemic coma (HP:0001325)3.10268626
12Osteomalacia (HP:0002749)3.09532920
13Hyperglycemia (HP:0003074)3.09248597
14True hermaphroditism (HP:0010459)3.04594957
15Bifid tongue (HP:0010297)3.02966806
16Hepatoblastoma (HP:0002884)2.99211744
17Abnormality of the pancreatic islet cells (HP:0006476)2.89830003
18Abnormality of endocrine pancreas physiology (HP:0012093)2.89830003
19Cortical dysplasia (HP:0002539)2.82091448
20Hypoplasia of the fovea (HP:0007750)2.79413940
21Aplasia/Hypoplasia of the fovea (HP:0008060)2.79413940
22Neoplasm of the adrenal gland (HP:0100631)2.78682089
23Type I transferrin isoform profile (HP:0003642)2.78096510
24Decreased circulating renin level (HP:0003351)2.74458401
25Medial flaring of the eyebrow (HP:0010747)2.71403717
26Congenital primary aphakia (HP:0007707)2.71251690
27Abnormality of the fovea (HP:0000493)2.71211113
28Action tremor (HP:0002345)2.64263151
29Intestinal atresia (HP:0011100)2.61812519
30Abnormality of calcium-phosphate metabolism (HP:0100530)2.58801127
31Abnormality of the lower motor neuron (HP:0002366)2.56955083
32Abnormality of the corticospinal tract (HP:0002492)2.56817742
33Neurofibrillary tangles (HP:0002185)2.55624519
34Insomnia (HP:0100785)2.54219258
35Pancreatic fibrosis (HP:0100732)2.52883726
36Hand muscle atrophy (HP:0009130)2.50312825
37Gait imbalance (HP:0002141)2.49960971
38Nephrogenic diabetes insipidus (HP:0009806)2.49639957
39Prominent metopic ridge (HP:0005487)2.48536892
40Absent eyebrow (HP:0002223)2.48489045
41Pheochromocytoma (HP:0002666)2.48036151
42Termporal pattern (HP:0011008)2.44108703
43Insidious onset (HP:0003587)2.44108703
44Abnormal protein glycosylation (HP:0012346)2.43581100
45Abnormal glycosylation (HP:0012345)2.43581100
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.43581100
47Abnormal protein N-linked glycosylation (HP:0012347)2.43581100
48Abnormality of glycolysis (HP:0004366)2.42621261
49Papillary thyroid carcinoma (HP:0002895)2.42489002
50Ankle clonus (HP:0011448)2.42347286
51Acute necrotizing encephalopathy (HP:0006965)2.39445895
52Dysautonomia (HP:0002459)2.38993613
53Neuroendocrine neoplasm (HP:0100634)2.38440637
54Abnormality of the metopic suture (HP:0005556)2.38354650
55Urinary urgency (HP:0000012)2.37051871
56Cerebral inclusion bodies (HP:0100314)2.37037143
57Increased serum pyruvate (HP:0003542)2.31161571
58Shoulder girdle muscle weakness (HP:0003547)2.30371593
5911 pairs of ribs (HP:0000878)2.29445974
60Pancreatic cysts (HP:0001737)2.28744229
61Vaginal atresia (HP:0000148)2.28638685
62Testicular neoplasm (HP:0010788)2.28175692
63Insulin-resistant diabetes mellitus (HP:0000831)2.25484495
64Spastic gait (HP:0002064)2.25005911
65Hypokalemia (HP:0002900)2.24366095
66Abnormal mitochondria in muscle tissue (HP:0008316)2.23787461
67Genital tract atresia (HP:0001827)2.23369470
68Supranuclear gaze palsy (HP:0000605)2.21409158
69Abnormality of dentin (HP:0010299)2.18504155
70Flat capital femoral epiphysis (HP:0003370)2.18023638
71Facial cleft (HP:0002006)2.17180096
72Split foot (HP:0001839)2.15930051
73Occipital encephalocele (HP:0002085)2.12787410
74Upper limb amyotrophy (HP:0009129)2.12171569
75Distal upper limb amyotrophy (HP:0007149)2.12171569
76Thyroid carcinoma (HP:0002890)2.12106204
77Median cleft lip (HP:0000161)2.10865732
78Generalized aminoaciduria (HP:0002909)2.10175209
79Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.08420869
80Degeneration of the lateral corticospinal tracts (HP:0002314)2.08420869
81Hammertoe (HP:0001765)2.08293737
82Patent foramen ovale (HP:0001655)2.05533865
83Polyphagia (HP:0002591)2.01703335
84Missing ribs (HP:0000921)2.01115741
85Progressive macrocephaly (HP:0004481)1.99418581
86Cerebral hypomyelination (HP:0006808)1.98852732
87Poor suck (HP:0002033)1.98079242
88Depression (HP:0000716)1.96189633
89Poor coordination (HP:0002370)1.94913808
90Hyperparathyroidism (HP:0000843)1.93967726
91Molar tooth sign on MRI (HP:0002419)1.93883998
92Abnormality of midbrain morphology (HP:0002418)1.93883998
93Agitation (HP:0000713)1.93834616
94Cystic liver disease (HP:0006706)1.91905496
95Aplasia involving bones of the extremities (HP:0009825)1.89801644
96Aplasia involving bones of the upper limbs (HP:0009823)1.89801644
97Aplasia of the phalanges of the hand (HP:0009802)1.89801644
98Turricephaly (HP:0000262)1.89640812
99Back pain (HP:0003418)1.89486308
100Menstrual irregularities (HP:0000858)1.87867245
101Overriding aorta (HP:0002623)1.87855088
102Abnormal eating behavior (HP:0100738)1.87584395
103Limb dystonia (HP:0002451)1.86837216
104Premature rupture of membranes (HP:0001788)1.86142317
105Apathy (HP:0000741)1.86097534
106Spastic diplegia (HP:0001264)1.85415527
107Sleep apnea (HP:0010535)1.84409521
108Peripheral hypomyelination (HP:0007182)1.83867432
109Hypoplastic left heart (HP:0004383)1.83428557
110Heterochromia iridis (HP:0001100)1.80484292
111Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.79455855
112Congenital sensorineural hearing impairment (HP:0008527)1.79392173
113Aplasia/Hypoplasia of the lens (HP:0008063)1.78761317
114Focal motor seizures (HP:0011153)1.78100585
115Abnormality of the hip-girdle musculature (HP:0001445)1.77853195
116Abnormality of the musculature of the pelvis (HP:0001469)1.77853195
117Large for gestational age (HP:0001520)1.77770250
118Ectopic anus (HP:0004397)1.76484577
119Metaphyseal dysplasia (HP:0100255)1.75599700
120Neoplasm of the adrenal cortex (HP:0100641)1.75316733
121Neoplasm of the thyroid gland (HP:0100031)1.75256313
122Diminished motivation (HP:0000745)1.74167790
123Abnormal biliary tract morphology (HP:0012440)1.73415857
124Flared iliac wings (HP:0002869)1.71537798
125Chronic bronchitis (HP:0004469)1.71320666
126Atrophy/Degeneration involving motor neurons (HP:0007373)1.70547426
127Long palpebral fissure (HP:0000637)1.69732216
128Optic nerve coloboma (HP:0000588)1.69498820
129Epiphyseal dysplasia (HP:0002656)1.68881758
130Impaired vibration sensation in the lower limbs (HP:0002166)1.68171346
131Preaxial hand polydactyly (HP:0001177)1.67722387
132Failure to thrive in infancy (HP:0001531)1.67607243
133Vertebral arch anomaly (HP:0008438)1.66862798
134Short middle phalanx of the 5th finger (HP:0004220)1.66694214
135Enlarged kidneys (HP:0000105)1.66557124
136Hyperacusis (HP:0010780)1.65702244
137Torticollis (HP:0000473)1.65682794
138Abnormality of potassium homeostasis (HP:0011042)1.63600801
139Broad distal phalanx of finger (HP:0009836)1.63587777
140Limb-girdle muscle atrophy (HP:0003797)1.63370076
141Broad foot (HP:0001769)1.62731048
142Delayed epiphyseal ossification (HP:0002663)1.61515261
143Abnormal autonomic nervous system physiology (HP:0012332)1.61241565
144Epileptic encephalopathy (HP:0200134)1.60957090
145Thoracolumbar scoliosis (HP:0002944)1.60732557
146CNS hypomyelination (HP:0003429)1.60665214
147Neuronal loss in central nervous system (HP:0002529)1.60487759
148Acute encephalopathy (HP:0006846)1.60298140
149Hydroureter (HP:0000072)1.58512768
150Achilles tendon contracture (HP:0001771)1.58449875
151Postnatal microcephaly (HP:0005484)1.58299396
152Generalized hypotonia (HP:0001290)1.57728112
153Generalized tonic-clonic seizures (HP:0002069)1.57268636
154Limb-girdle muscle weakness (HP:0003325)1.57222748
155Spinal muscular atrophy (HP:0007269)1.56536542
156Abnormal gallbladder physiology (HP:0012438)1.56249663
157Cholecystitis (HP:0001082)1.56249663
158Abnormality of the motor neurons (HP:0002450)1.56064200
159Abnormal neuron morphology (HP:0012757)1.56064200
160Increased nuchal translucency (HP:0010880)1.55642503
161Abnormality of the foot musculature (HP:0001436)1.55560543
162Tongue fasciculations (HP:0001308)1.55532237
163Absent eyelashes (HP:0000561)1.53667282
164Postaxial hand polydactyly (HP:0001162)1.52938787
165Exercise-induced muscle cramps (HP:0003710)1.52892347
166Ketoacidosis (HP:0001993)1.52577613
167Spastic tetraplegia (HP:0002510)1.52169450
168Foot dorsiflexor weakness (HP:0009027)1.51701087
169Aplasia/Hypoplasia of the tongue (HP:0010295)1.51239011
170Shallow orbits (HP:0000586)1.50570277
171Glucose intolerance (HP:0000833)1.50305632
172Disproportionate short-trunk short stature (HP:0003521)1.50229591
173Irregular vertebral endplates (HP:0003301)1.49620019
174Akinesia (HP:0002304)1.49184724
175Dysmetria (HP:0001310)1.48674499
176Proximal placement of thumb (HP:0009623)1.48367072
177Asymmetry of the thorax (HP:0001555)1.48092701
178Aplasia/hypoplasia of the uterus (HP:0008684)1.47823834
179Lower limb muscle weakness (HP:0007340)1.47366118
180Pointed chin (HP:0000307)1.46644101
181Hypercortisolism (HP:0001578)1.46598512
182Focal dystonia (HP:0004373)1.46451265
183Microglossia (HP:0000171)1.46394657
184Fetal akinesia sequence (HP:0001989)1.46025459
185Epileptiform EEG discharges (HP:0011182)1.45656160
186Intention tremor (HP:0002080)1.44742586
187Craniofacial dystonia (HP:0012179)1.44056407
188Focal seizures (HP:0007359)1.42780348
189Morphological abnormality of the pyramidal tract (HP:0002062)1.41704087
190Congenital glaucoma (HP:0001087)1.41169120
191Growth hormone excess (HP:0000845)1.41004804
192Pelvic girdle muscle weakness (HP:0003749)1.39541640
193EEG with generalized epileptiform discharges (HP:0011198)1.39504197
194Coronal craniosynostosis (HP:0004440)1.39423764
195Hypsarrhythmia (HP:0002521)1.39242720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK3.58181693
2ERBB33.45706196
3PRKD33.38942745
4MARK13.20299062
5ZAK3.14222672
6FRK3.08093610
7INSRR2.76946051
8BMPR22.74466598
9SIK32.69691440
10STK38L2.67667102
11BCR2.56346192
12MAPK152.51146620
13AKT32.44780153
14LATS22.36690129
15BRSK22.14685417
16PAK62.13438609
17EPHA41.95056205
18WNK41.92895407
19WNK31.90996032
20PLK21.82313743
21MAP3K21.76284101
22NTRK21.74705513
23EIF2AK31.71793339
24PLK31.69980227
25SCYL21.64011619
26CDK191.61076381
27CASK1.61007563
28TRIM281.58523602
29NTRK31.56854166
30TESK11.56534794
31MKNK11.52390722
32MAP3K91.50944581
33PNCK1.50279868
34PRPF4B1.44306139
35BRAF1.39455695
36CDK181.29626946
37NEK61.29407440
38LIMK11.29384708
39CDK151.26308031
40CDK11A1.24832487
41STK241.22347828
42SRPK11.21567174
43ICK1.20850915
44EIF2AK11.18996230
45RIPK11.18888196
46EPHB21.18848306
47MOS1.16040859
48BRSK11.15917611
49HIPK21.15861900
50TESK21.15436768
51OBSCN1.15156905
52CSNK1G21.13995023
53NME11.13657382
54PIM21.13473886
55PDK21.12060245
56FER1.11435207
57ARAF1.10400114
58CDC42BPA1.09920506
59MKNK21.07802894
60PLK41.05758902
61PAK31.04204687
62BMPR1B1.03295447
63CDC71.00460857
64CSNK1G30.98862717
65CDK80.97186265
66SGK20.96939023
67KSR10.96204916
68DYRK20.95659413
69UHMK10.94171956
70VRK10.93780262
71CAMK2G0.92804038
72SGK4940.92486271
73SGK2230.92486271
74PDGFRA0.91514379
75CAMK2B0.91389059
76TRIB30.91196042
77CSNK1A1L0.88828040
78CDK50.87771446
79MAP3K30.85992483
80ROCK20.85976205
81PAK40.85585088
82MAP3K40.84101733
83PBK0.83944427
84MINK10.82775294
85DYRK1B0.82447515
86BUB10.81970220
87FLT30.81197231
88ALK0.81132727
89IRAK30.79371496
90CAMKK20.78773380
91TYRO30.78676328
92DMPK0.77855067
93NEK90.77311296
94YES10.77274597
95PHKG20.77156573
96PHKG10.77156573
97PRKCE0.76616709
98CSNK1G10.75777521
99AKT20.75768458
100DAPK10.74905564
101TTK0.74131135
102IRAK10.72811600
103SIK20.72362685
104NME20.68322710
105PIK3CG0.66885048
106WNK10.65404679
107CAMKK10.64067688
108KSR20.63856586
109CSNK1E0.62660709
110RPS6KB10.61380144
111IRAK20.60691904
112TSSK60.60605194
113DYRK30.60008148
114AURKA0.58811260
115PAK20.57516724
116ABL20.56673072
117MYLK0.55914021
118TNIK0.55781939
119CAMK2A0.55228057
120CAMK2D0.53876051
121PRKG20.53168811
122EPHA30.52303304
123MET0.50868472
124NTRK10.50746371
125PKN20.50738453
126DYRK1A0.50223236
127ADRBK20.49776686
128ERBB40.49293042
129PTK20.48906027
130MAPK100.48872393
131PLK10.45788590
132EPHA20.44540439
133ILK0.43859556
134MAP3K10.43644244
135MAPK130.43615822
136PRKCH0.43280713
137STK160.42487711
138MAP2K40.42411097
139CSNK1A10.41807948
140NEK10.41766955
141CSNK2A10.39787723
142PRKCI0.39741359
143MAP2K10.39739641
144PAK10.39397721
145STK380.39250607
146BCKDK0.39158429
147EIF2AK20.37912887
148CHUK0.36873223
149IRAK40.36439685
150MAP3K140.35398873
151LMTK20.35306713
152WEE10.33185914
153RPS6KA40.32701090
154PRKCG0.31359838
155MARK30.31180435
156MAPKAPK20.31137907
157MAP2K70.29872722
158ATR0.28538070
159ATM0.27673072
160CDK30.26505444
161CDK140.25027749
162RPS6KA50.23355284

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030606.29863631
2Maturity onset diabetes of the young_Homo sapiens_hsa049505.48209789
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.76522124
4Vibrio cholerae infection_Homo sapiens_hsa051102.61110818
5Sulfur metabolism_Homo sapiens_hsa009202.56849636
6Proteasome_Homo sapiens_hsa030502.14223585
7SNARE interactions in vesicular transport_Homo sapiens_hsa041302.12652568
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12507114
9Insulin secretion_Homo sapiens_hsa049112.10021144
10Nicotine addiction_Homo sapiens_hsa050331.82754262
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79182837
12N-Glycan biosynthesis_Homo sapiens_hsa005101.77468169
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77350693
14Biosynthesis of amino acids_Homo sapiens_hsa012301.76116752
15Oxidative phosphorylation_Homo sapiens_hsa001901.67142266
16Type I diabetes mellitus_Homo sapiens_hsa049401.59254830
17Steroid biosynthesis_Homo sapiens_hsa001001.57155149
18Parkinsons disease_Homo sapiens_hsa050121.47241949
19RNA polymerase_Homo sapiens_hsa030201.45058466
20Carbon metabolism_Homo sapiens_hsa012001.43619972
21Arginine and proline metabolism_Homo sapiens_hsa003301.42341820
22Fatty acid elongation_Homo sapiens_hsa000621.41132182
23Pyruvate metabolism_Homo sapiens_hsa006201.40329503
24Vitamin B6 metabolism_Homo sapiens_hsa007501.36794622
25Huntingtons disease_Homo sapiens_hsa050161.32282217
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30032445
27Collecting duct acid secretion_Homo sapiens_hsa049661.29458899
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29086211
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28831167
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27974151
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25635105
32Thyroid cancer_Homo sapiens_hsa052161.25449849
33Basal transcription factors_Homo sapiens_hsa030221.24538158
34Mismatch repair_Homo sapiens_hsa034301.23848167
35Synaptic vesicle cycle_Homo sapiens_hsa047211.22024207
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21709710
37RNA degradation_Homo sapiens_hsa030181.20985208
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20026755
39Amphetamine addiction_Homo sapiens_hsa050311.19361683
40Axon guidance_Homo sapiens_hsa043601.12895220
41Cocaine addiction_Homo sapiens_hsa050301.12836689
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12355246
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12112139
44RNA transport_Homo sapiens_hsa030131.05720268
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.05264000
46Alzheimers disease_Homo sapiens_hsa050101.04782819
47Sulfur relay system_Homo sapiens_hsa041221.04737840
48Cell cycle_Homo sapiens_hsa041101.03474401
49Galactose metabolism_Homo sapiens_hsa000521.02468141
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01483470
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98457828
52Glutamatergic synapse_Homo sapiens_hsa047240.97524551
53Dopaminergic synapse_Homo sapiens_hsa047280.95518557
54Serotonergic synapse_Homo sapiens_hsa047260.93327400
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91416412
56beta-Alanine metabolism_Homo sapiens_hsa004100.91163432
57Circadian rhythm_Homo sapiens_hsa047100.90624650
58Spliceosome_Homo sapiens_hsa030400.89437889
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.88541613
60Base excision repair_Homo sapiens_hsa034100.87221564
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87023130
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86927171
63Phenylalanine metabolism_Homo sapiens_hsa003600.85712060
64Gap junction_Homo sapiens_hsa045400.85680310
65Purine metabolism_Homo sapiens_hsa002300.85017017
66Long-term potentiation_Homo sapiens_hsa047200.83771475
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83760279
68Nucleotide excision repair_Homo sapiens_hsa034200.83708611
69mRNA surveillance pathway_Homo sapiens_hsa030150.83490910
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83235372
71Circadian entrainment_Homo sapiens_hsa047130.83018505
72Pentose phosphate pathway_Homo sapiens_hsa000300.82337202
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81588932
74Alcoholism_Homo sapiens_hsa050340.81513098
75Pyrimidine metabolism_Homo sapiens_hsa002400.81102057
76Thyroid hormone synthesis_Homo sapiens_hsa049180.81035192
77Homologous recombination_Homo sapiens_hsa034400.74981104
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74780547
79Non-homologous end-joining_Homo sapiens_hsa034500.74762649
80Fructose and mannose metabolism_Homo sapiens_hsa000510.72431544
81Taste transduction_Homo sapiens_hsa047420.71931364
82Hippo signaling pathway_Homo sapiens_hsa043900.70644760
83AMPK signaling pathway_Homo sapiens_hsa041520.70426948
84Propanoate metabolism_Homo sapiens_hsa006400.69688716
85DNA replication_Homo sapiens_hsa030300.69290380
86Oocyte meiosis_Homo sapiens_hsa041140.67462209
87Cardiac muscle contraction_Homo sapiens_hsa042600.67285942
88TGF-beta signaling pathway_Homo sapiens_hsa043500.67280119
89Phagosome_Homo sapiens_hsa041450.66718125
90Fatty acid metabolism_Homo sapiens_hsa012120.65430488
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65125505
92GABAergic synapse_Homo sapiens_hsa047270.63995942
93Type II diabetes mellitus_Homo sapiens_hsa049300.63887899
94Arachidonic acid metabolism_Homo sapiens_hsa005900.63426399
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63259625
96Estrogen signaling pathway_Homo sapiens_hsa049150.62453010
97Hedgehog signaling pathway_Homo sapiens_hsa043400.62102729
98Regulation of autophagy_Homo sapiens_hsa041400.61225877
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60181543
100Lysosome_Homo sapiens_hsa041420.60129623
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58679678
102Selenocompound metabolism_Homo sapiens_hsa004500.58470133
103Arginine biosynthesis_Homo sapiens_hsa002200.58042585
104Basal cell carcinoma_Homo sapiens_hsa052170.57989319
105Melanogenesis_Homo sapiens_hsa049160.56670655
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56663845
107Legionellosis_Homo sapiens_hsa051340.55900965
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55647421
109Prostate cancer_Homo sapiens_hsa052150.54912972
110Prion diseases_Homo sapiens_hsa050200.54735590
111Folate biosynthesis_Homo sapiens_hsa007900.54708715
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54638928
113Gastric acid secretion_Homo sapiens_hsa049710.54432872
114Dilated cardiomyopathy_Homo sapiens_hsa054140.53832555
115Tight junction_Homo sapiens_hsa045300.51636659
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50648021
117Glucagon signaling pathway_Homo sapiens_hsa049220.50563452
118Phototransduction_Homo sapiens_hsa047440.50511488
119Cholinergic synapse_Homo sapiens_hsa047250.49819376
120Sphingolipid metabolism_Homo sapiens_hsa006000.49263627
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48750854
122Endocytosis_Homo sapiens_hsa041440.48171068
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48143329
124Adherens junction_Homo sapiens_hsa045200.47812869
125Morphine addiction_Homo sapiens_hsa050320.46707208
126ErbB signaling pathway_Homo sapiens_hsa040120.46223557
127Wnt signaling pathway_Homo sapiens_hsa043100.45901812
128Notch signaling pathway_Homo sapiens_hsa043300.45229564
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44022141
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.43889884
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43706902
132Olfactory transduction_Homo sapiens_hsa047400.43589515
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41274458
134Insulin signaling pathway_Homo sapiens_hsa049100.41094034
135Melanoma_Homo sapiens_hsa052180.39617096
136Rheumatoid arthritis_Homo sapiens_hsa053230.39051674
137cAMP signaling pathway_Homo sapiens_hsa040240.37289430
138Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36757327
139Long-term depression_Homo sapiens_hsa047300.36279777
140Pancreatic secretion_Homo sapiens_hsa049720.35635109
141Epstein-Barr virus infection_Homo sapiens_hsa051690.35104932
142Antigen processing and presentation_Homo sapiens_hsa046120.34792850
143Prolactin signaling pathway_Homo sapiens_hsa049170.34448439
144One carbon pool by folate_Homo sapiens_hsa006700.34162132
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33732100
146Endometrial cancer_Homo sapiens_hsa052130.33697541
147Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33442574
148Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32526067

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